Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 45439370
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45439370 TAO kinase 1 [Homo sapiens]
(1001 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45439370 TAO kinase 1 [Homo sapiens] 1998 0.0
gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens] 1426 0.0
gi|148746218 TAO kinase 3 [Homo sapiens] 1320 0.0
gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens] 1077 0.0
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 251 2e-66
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 251 2e-66
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 249 7e-66
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 249 7e-66
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 246 8e-65
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 240 4e-63
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 239 1e-62
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 239 1e-62
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 238 2e-62
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 238 2e-62
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 238 2e-62
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 237 5e-62
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 237 5e-62
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 231 2e-60
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 230 4e-60
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 229 1e-59
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 227 4e-59
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 225 1e-58
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 225 1e-58
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 225 1e-58
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 225 1e-58
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 225 2e-58
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 218 2e-56
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 214 3e-55
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 211 3e-54
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 204 4e-52
>gi|45439370 TAO kinase 1 [Homo sapiens]
Length = 1001
Score = 1998 bits (5175), Expect = 0.0
Identities = 1001/1001 (100%), Positives = 1001/1001 (100%)
Query: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS
Sbjct: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
Query: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHK 120
YSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHK
Sbjct: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHK 120
Query: 121 KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPAN 180
KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPAN
Sbjct: 121 KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPAN 180
Query: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN
Sbjct: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
Query: 241 ESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDA 300
ESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDA
Sbjct: 241 ESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDA 300
Query: 301 VRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSIS 360
VRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSIS
Sbjct: 301 VRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSIS 360
Query: 361 ASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQ 420
ASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQ
Sbjct: 361 ASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQ 420
Query: 421 SPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMT 480
SPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMT
Sbjct: 421 SPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMT 480
Query: 481 LENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHI 540
LENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHI
Sbjct: 481 LENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHI 540
Query: 541 QAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEE 600
QAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEE
Sbjct: 541 QAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEE 600
Query: 601 ANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQ 660
ANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQ
Sbjct: 601 ANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQ 660
Query: 661 ELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKEL 720
ELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKEL
Sbjct: 661 ELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKEL 720
Query: 721 QIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSIN 780
QIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSIN
Sbjct: 721 QIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSIN 780
Query: 781 EMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSL 840
EMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSL
Sbjct: 781 EMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSL 840
Query: 841 RRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAF 900
RRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAF
Sbjct: 841 RRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAF 900
Query: 901 SHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSM 960
SHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSM
Sbjct: 901 SHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSM 960
Query: 961 GVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT 1001
GVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT
Sbjct: 961 GVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT 1001
>gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens]
Length = 1049
Score = 1426 bits (3691), Expect = 0.0
Identities = 739/1050 (70%), Positives = 843/1050 (80%), Gaps = 50/1050 (4%)
Query: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
MP+ RAGSLKDP++AELFFK+DPEKLF+DLREIGHGSFGAVYFARDVR +EVVAIKKMS
Sbjct: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
Query: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHK 120
YSGKQS EKWQDIIKEV+FLQ+++HPN+I+Y+GCYLREHTAWLVMEYCLGSASDLLEVHK
Sbjct: 61 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK 120
Query: 121 KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPAN 180
KPLQEVEIAA+THGALQGLAYLHSH MIHRD+KAGNILL+EPG VKL DFGSAS+ +PAN
Sbjct: 121 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN 180
Query: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN
Sbjct: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
Query: 241 ESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDA 300
ESP LQS WS+YFRNFVDSCLQKIPQDRPTSE LLKH FVLRERP TV++DLIQRTKDA
Sbjct: 241 ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA 300
Query: 301 VRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSIS 360
VRELDNLQYRKMKK+LFQEA NGP EA EEEEE + + R GT+ S+ S+ S+PSMSIS
Sbjct: 301 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS 360
Query: 361 ASSQSSSVNSLPDVSDDKSELD-------------------MMEGDHTVMSNSSVIHLKP 401
ASSQSSSVNSL D SD++ E + M EG+HTV S+SS+IH P
Sbjct: 361 ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP 420
Query: 402 EEEN-----YREEGDPRT----RASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQ 452
+N Y+ E P A P S +R +++ RNR+HFATIRTASLV+RQ+Q
Sbjct: 421 GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ 480
Query: 453 EHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEME 512
EHEQDS LREQ+SGYKRMRRQHQKQL+ LE++L+ E +EH RL ++LE QR F AE E
Sbjct: 481 EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE 540
Query: 513 KLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNE 572
KL ++HQA EKEA+ EE+KFQQHI QQKKEL + LE+QKR YKLRKEQLKEEL E
Sbjct: 541 KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE 600
Query: 573 NQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQD 632
N STPK+EK EWL +QKE +Q QAEEEA LLRRQRQY EL+CR++KR+MLL RH+L+QD
Sbjct: 601 NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD 660
Query: 633 LVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEY 692
L+RE+LNK+QTQKDLE A+LLRQHE+ +ELE R L +Q+ R EL RLQHQTEL NQLEY
Sbjct: 661 LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY 720
Query: 693 NKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSE 752
NKRRE+ELR+KH +VRQQPKSLKSKELQIKKQFQ+TCKIQTRQYKALR HLLETTPK++
Sbjct: 721 NKRREQELRQKHAAQVRQQPKSLKSKELQIKKQFQETCKIQTRQYKALRAHLLETTPKAQ 780
Query: 753 HKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELL 812
HK++LKRLKEEQTRKLAILAEQYD SI+EMLS+QALRLDE QEAE Q L+ QLQQELELL
Sbjct: 781 HKSLLKRLKEEQTRKLAILAEQYDQSISEMLSSQALRLDETQEAEFQALRQQLQQELELL 840
Query: 813 NAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQA 872
NAYQSKIK++ E+QH+RELRELEQRV+LRRALLEQ++EEE+LALQ R+ERIRSLLERQA
Sbjct: 841 NAYQSKIKIRTESQHERELRELEQRVALRRALLEQRVEEELLALQTGRSERIRSLLERQA 900
Query: 873 REIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPG---ASGWSHNPTGGPGPHWGH---PM 926
REIEAFD+ESMRLGFS+M L + EA + YP A W P G HW H P
Sbjct: 901 REIEAFDAESMRLGFSSMALGGIPAEAAAQGYPAPPPAPAWPSRPVPRSGAHWSHGPPPP 960
Query: 927 GGPPQAWGHP---MQGGPQPWGHPSGPMQGVPRGSS-MGVRNSPQALRRTASGGRTEQG- 981
G PP AW P GP W P G PRG + + +RNSPQ LRR ASGG +
Sbjct: 961 GMPPPAWRQPSLLAPPGPPNWLGPP-TQSGTPRGGALLLLRNSPQPLRRAASGGSGSENV 1019
Query: 982 ----------MSRSTSVTSQISNGSHMSYT 1001
+SRSTSV S I NGS Y+
Sbjct: 1020 GPPAAAVPGPLSRSTSVASHILNGSSHFYS 1049
>gi|148746218 TAO kinase 3 [Homo sapiens]
Length = 898
Score = 1320 bits (3417), Expect = 0.0
Identities = 662/900 (73%), Positives = 775/900 (86%), Gaps = 9/900 (1%)
Query: 6 RAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQ 65
R G LKDPEIA+LF+K+DPE+LF L EIGHGSFGAVYFA + T+EVVAIKKMSYSGKQ
Sbjct: 2 RKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQ 61
Query: 66 STEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQE 125
+ EKWQDI+KEVKFL+++KHPN+IEYKGCYL+EHTAWLVMEYCLGSASDLLEVHKKPLQE
Sbjct: 62 THEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQE 121
Query: 126 VEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGT 185
VEIAAITHGAL GLAYLHSH +IHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGT
Sbjct: 122 VEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGT 181
Query: 186 PYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTL 245
PYWMAPEVILAMDEGQYDGKVD+WSLGITCIELAERKPPLFNMNAMSALYHIAQN+SPTL
Sbjct: 182 PYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTL 241
Query: 246 QSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELD 305
QSNEW+D FR FVD CLQKIPQ+RPTS ELL+H FV R+RP VLIDLIQRTKDAVRELD
Sbjct: 242 QSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELD 301
Query: 306 NLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQS 365
NLQYRKMKK+LFQE NGP E+QE+EE+ +HG ++S+GSN SIPSMS+S SQS
Sbjct: 302 NLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQS 361
Query: 366 SSVNSLPDVSDDKS-ELDMMEGDH-TVMSNSSVIHLKPEEENYREE---GDPRTRASDPQ 420
SSVNS+ +V D+ S EL MM D T+ S+SSV+H K + R+E GDPR +P+
Sbjct: 362 SSVNSMQEVMDESSSELVMMHDDESTINSSSSVVH-KKDHVFIRDEAGHGDPRP---EPR 417
Query: 421 SPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMT 480
V HYRNRE FATI++ASLVTRQ+ EHEQ++ELREQMSGYKRMRRQHQKQL+
Sbjct: 418 PTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIA 477
Query: 481 LENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHI 540
LENKLKAEMDEHRL+L K++ET NN + E+EKL KK A +EKEAKV + +EKKFQQ I
Sbjct: 478 LENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQI 537
Query: 541 QAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEE 600
AQQKK+L +FLESQK++YK+ KE++KEE+NE+ STPKKEKQE +SK KEN+QH QAEEE
Sbjct: 538 LAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEE 597
Query: 601 ANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQ 660
A+LL +QR Y + CR FKR++++ RH +EQ +REELNK++TQK++EHAML+R ES +
Sbjct: 598 AHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTR 657
Query: 661 ELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKEL 720
ELE+R L+T+QK+R +LIRLQHQTEL NQLEYNKRREREL RKHVME+RQQPK+LK+ E+
Sbjct: 658 ELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEM 717
Query: 721 QIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSIN 780
QIKKQFQDTCK+QT+QYKAL+NH LE TPK+EHK +LK LK+EQTRKLAILAEQY+ SIN
Sbjct: 718 QIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSIN 777
Query: 781 EMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSL 840
EM+++QALRLDEAQEAECQ L++QLQQE+ELLNAYQSKIKMQ EAQH+REL++LEQRVSL
Sbjct: 778 EMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSL 837
Query: 841 RRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAF 900
RRA LEQKIEEE+ ALQ ER+ERI++LLERQ REIE FD ES+R+GF N+V + E +
Sbjct: 838 RRAHLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGNLVTLDFPKEDY 897
>gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens]
Length = 1235
Score = 1077 bits (2785), Expect = 0.0
Identities = 542/744 (72%), Positives = 619/744 (83%), Gaps = 28/744 (3%)
Query: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
MP+ RAGSLKDP++AELFFK+DPEKLF+DLREIGHGSFGAVYFARDVR +EVVAIKKMS
Sbjct: 1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS 60
Query: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHK 120
YSGKQS EKWQDIIKEV+FLQ+++HPN+I+Y+GCYLREHTAWLVMEYCLGSASDLLEVHK
Sbjct: 61 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK 120
Query: 121 KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPAN 180
KPLQEVEIAA+THGALQGLAYLHSH MIHRD+KAGNILL+EPG VKL DFGSAS+ +PAN
Sbjct: 121 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN 180
Query: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN
Sbjct: 181 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN 240
Query: 241 ESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDA 300
ESP LQS WS+YFRNFVDSCLQKIPQDRPTSE LLKH FVLRERP TV++DLIQRTKDA
Sbjct: 241 ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA 300
Query: 301 VRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSIS 360
VRELDNLQYRKMKK+LFQEA NGP EA EEEEE + + R GT+ S+ S+ S+PSMSIS
Sbjct: 301 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS 360
Query: 361 ASSQSSSVNSLPDVSDDKSELD-------------------MMEGDHTVMSNSSVIHLKP 401
ASSQSSSVNSL D SD++ E + M EG+HTV S+SS+IH P
Sbjct: 361 ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP 420
Query: 402 EEEN-----YREEGDPR----TRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQ 452
+N Y+ E P A P S +R +++ RNR+HFATIRTASLV+RQ+Q
Sbjct: 421 GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ 480
Query: 453 EHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEME 512
EHEQDS LREQ+SGYKRMRRQHQKQL+ LE++L+ E +EH RL ++LE QR F AE E
Sbjct: 481 EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE 540
Query: 513 KLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNE 572
KL ++HQA EKEA+ EE+KFQQHI QQKKEL + LE+QKR YKLRKEQLKEEL E
Sbjct: 541 KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE 600
Query: 573 NQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQD 632
N STPK+EK EWL +QKE +Q QAEEEA LLRRQRQY EL+CR++KR+MLL RH+L+QD
Sbjct: 601 NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD 660
Query: 633 LVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEY 692
L+RE+LNK+QTQKDLE A+LLRQHE+ +ELE R L +Q+ R EL RLQHQTEL NQLEY
Sbjct: 661 LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY 720
Query: 693 NKRRERELRRKHVMEVRQQPKSLK 716
NKRRE+ELR+KH +VRQQPKSLK
Sbjct: 721 NKRREQELRQKHAAQVRQQPKSLK 744
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 251 bits (641), Expect = 2e-66
Identities = 188/611 (30%), Positives = 304/611 (49%), Gaps = 93/611 (15%)
Query: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
M S + A SL + +++ L DP +F + +G+G++G VY R V+T ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIE-YKGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L++ H +I Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFG 171
+DL++ K L+E IA I L+GL++LH H +IHRDIK N+LLTE +VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SASMASPA----NSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRE 284
L +M+ M AL+ I +N +P L+S +WS F++F++SCL K RP +E+L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----ETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGV 339
+P L D I RTK E D +Y ++G ++EEEEE D G
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYE----------YSG----SEEEEEENDSG- 336
Query: 340 GRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHL 399
+ SS+ +LP S + + ++ S
Sbjct: 337 ------------------------EPSSILNLPGESTLRRDFLRLQ---LANKERSEALR 369
Query: 400 KPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSE 459
+ + E + E + R + ++ K R E ++ ++ E
Sbjct: 370 RQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE---------------EQQRREKE 414
Query: 460 LREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQ 519
LR+Q + RR +++Q+ E + +AE ++ +R + LE ++ ++L+ H+
Sbjct: 415 LRKQQE--REQRRHYEEQMRREEERRRAEHEQEYIR--RQLEEEQRQLEILQQQLL--HE 468
Query: 520 AAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKK 579
A+ E K EE++ + +Q Q K+E + + Q + + R + K + +
Sbjct: 469 QALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPS 528
Query: 580 EKQEWLSKQKE 590
EK W + +E
Sbjct: 529 EKPAWAKEVEE 539
Score = 58.5 bits (140), Expect = 3e-08
Identities = 96/389 (24%), Positives = 156/389 (40%), Gaps = 89/389 (22%)
Query: 534 KKFQQHIQ-----------AQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQ 582
KKFQ I+ A ++ + F+ Q E ++R QLK+ ++ K+K+
Sbjct: 260 KKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI-QLKDHIDRT-----KKKR 313
Query: 583 EWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQ 642
+ + + EEE N L L G L +D +R +L ++
Sbjct: 314 GEKDETEYEYSGSEEEEEENDSGEPSSILNLP----------GESTLRRDFLRLQLANKE 363
Query: 643 TQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRR 702
+ L L +Q +E + + L QK R++ Q E +LE +RRE+ELR+
Sbjct: 364 RSEALRRQQLEQQQRENEEHKRQLLAERQK------RIEEQKEQRRRLEEQQRREKELRK 417
Query: 703 KHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKA-VLKRLK 761
+ E R+ + +E E ++EH+ ++R
Sbjct: 418 QQEREQRRHYEEQMRRE--------------------------EERRRAEHEQEYIRRQL 451
Query: 762 EEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKM 821
EE+ R+L IL +Q H +L + +L+E ++AE L+ QL+QE + L
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAE--RLQRQLKQERDYL--------- 500
Query: 822 QAEAQHDRELRELEQRVSLRRALLEQK---IEEEMLALQNERTERIRSLLERQAREIEAF 878
QH R+ EQR ++ L K E A E ER R L RQ+
Sbjct: 501 -VSLQHQRQ----EQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSR--LNRQS------ 547
Query: 879 DSESMRLGFSNMVLS-NLSPEAFSHSYPG 906
S +M +N + NL P + S S G
Sbjct: 548 -SPAMPHKVANRISDPNLPPRSESFSISG 575
Score = 48.9 bits (115), Expect = 2e-05
Identities = 54/243 (22%), Positives = 108/243 (44%), Gaps = 23/243 (9%)
Query: 436 EHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLR 495
E I+ + R ++ + E + SG + ++ + L E R
Sbjct: 295 ERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDF 354
Query: 496 LDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQ 555
L L + + A ++L ++ + E + ++++ +K+ ++ Q +Q++ L E Q
Sbjct: 355 LRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE--QKEQRRRLE---EQQ 409
Query: 556 KREYKLRKEQLKEELNENQSTPKKE--------KQEWLSKQKEN-------IQHFQAEEE 600
+RE +LRK+Q +E+ + ++E +QE++ +Q E +Q E+
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQ 469
Query: 601 ANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQ 660
A LL +R+ LE E R+ +R L + E+D + ++RQ Q+ +E L E M
Sbjct: 470 ALLLEYKRKQLE-EQRQAER--LQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMS 526
Query: 661 ELE 663
E
Sbjct: 527 PSE 529
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 251 bits (641), Expect = 2e-66
Identities = 188/611 (30%), Positives = 304/611 (49%), Gaps = 93/611 (15%)
Query: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
M S + A SL + +++ L DP +F + +G+G++G VY R V+T ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIE-YKGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L++ H +I Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFG 171
+DL++ K L+E IA I L+GL++LH H +IHRDIK N+LLTE +VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SASMASPA----NSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRE 284
L +M+ M AL+ I +N +P L+S +WS F++F++SCL K RP +E+L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----ETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGV 339
+P L D I RTK E D +Y ++G ++EEEEE D G
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYE----------YSG----SEEEEEENDSG- 336
Query: 340 GRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHL 399
+ SS+ +LP S + + ++ S
Sbjct: 337 ------------------------EPSSILNLPGESTLRRDFLRLQ---LANKERSEALR 369
Query: 400 KPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSE 459
+ + E + E + R + ++ K R E ++ ++ E
Sbjct: 370 RQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE---------------EQQRREKE 414
Query: 460 LREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQ 519
LR+Q + RR +++Q+ E + +AE ++ +R + LE ++ ++L+ H+
Sbjct: 415 LRKQQE--REQRRHYEEQMRREEERRRAEHEQEYIR--RQLEEEQRQLEILQQQLL--HE 468
Query: 520 AAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKK 579
A+ E K EE++ + +Q Q K+E + + Q + + R + K + +
Sbjct: 469 QALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPS 528
Query: 580 EKQEWLSKQKE 590
EK W + +E
Sbjct: 529 EKPAWAKEVEE 539
Score = 58.5 bits (140), Expect = 3e-08
Identities = 96/389 (24%), Positives = 156/389 (40%), Gaps = 89/389 (22%)
Query: 534 KKFQQHIQ-----------AQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQ 582
KKFQ I+ A ++ + F+ Q E ++R QLK+ ++ K+K+
Sbjct: 260 KKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI-QLKDHIDRT-----KKKR 313
Query: 583 EWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQ 642
+ + + EEE N L L G L +D +R +L ++
Sbjct: 314 GEKDETEYEYSGSEEEEEENDSGEPSSILNLP----------GESTLRRDFLRLQLANKE 363
Query: 643 TQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRR 702
+ L L +Q +E + + L QK R++ Q E +LE +RRE+ELR+
Sbjct: 364 RSEALRRQQLEQQQRENEEHKRQLLAERQK------RIEEQKEQRRRLEEQQRREKELRK 417
Query: 703 KHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKA-VLKRLK 761
+ E R+ + +E E ++EH+ ++R
Sbjct: 418 QQEREQRRHYEEQMRRE--------------------------EERRRAEHEQEYIRRQL 451
Query: 762 EEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKM 821
EE+ R+L IL +Q H +L + +L+E ++AE L+ QL+QE + L
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAE--RLQRQLKQERDYL--------- 500
Query: 822 QAEAQHDRELRELEQRVSLRRALLEQK---IEEEMLALQNERTERIRSLLERQAREIEAF 878
QH R+ EQR ++ L K E A E ER R L RQ+
Sbjct: 501 -VSLQHQRQ----EQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSR--LNRQS------ 547
Query: 879 DSESMRLGFSNMVLS-NLSPEAFSHSYPG 906
S +M +N + NL P + S S G
Sbjct: 548 -SPAMPHKVANRISDPNLPPRSESFSISG 575
Score = 48.9 bits (115), Expect = 2e-05
Identities = 54/243 (22%), Positives = 108/243 (44%), Gaps = 23/243 (9%)
Query: 436 EHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLR 495
E I+ + R ++ + E + SG + ++ + L E R
Sbjct: 295 ERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDF 354
Query: 496 LDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQ 555
L L + + A ++L ++ + E + ++++ +K+ ++ Q +Q++ L E Q
Sbjct: 355 LRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE--QKEQRRRLE---EQQ 409
Query: 556 KREYKLRKEQLKEELNENQSTPKKE--------KQEWLSKQKEN-------IQHFQAEEE 600
+RE +LRK+Q +E+ + ++E +QE++ +Q E +Q E+
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQ 469
Query: 601 ANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQ 660
A LL +R+ LE E R+ +R L + E+D + ++RQ Q+ +E L E M
Sbjct: 470 ALLLEYKRKQLE-EQRQAER--LQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMS 526
Query: 661 ELE 663
E
Sbjct: 527 PSE 529
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 249 bits (637), Expect = 7e-66
Identities = 187/605 (30%), Positives = 301/605 (49%), Gaps = 93/605 (15%)
Query: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
M S + A SL + +++ L DP +F + +G+G++G VY R V+T ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIE-YKGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L++ H +I Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFG 171
+DL++ K L+E IA I L+GL++LH H +IHRDIK N+LLTE +VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SASMASPA----NSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRE 284
L +M+ M AL+ I +N +P L+S +WS F++F++SCL K RP +E+L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----ETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGV 339
+P L D I RTK E D +Y ++G ++EEEEE D G
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYE----------YSG----SEEEEEENDSG- 336
Query: 340 GRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHL 399
+ SS+ +LP S + + ++ S
Sbjct: 337 ------------------------EPSSILNLPGESTLRRDFLRLQ---LANKERSEALR 369
Query: 400 KPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSE 459
+ + E + E + R + ++ K R E ++ ++ E
Sbjct: 370 RQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE---------------EQQRREKE 414
Query: 460 LREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQ 519
LR+Q + RR +++Q+ E + +AE ++ +R + LE ++ ++L+ H+
Sbjct: 415 LRKQQE--REQRRHYEEQMRREEERRRAEHEQEYIR--RQLEEEQRQLEILQQQLL--HE 468
Query: 520 AAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKK 579
A+ E K EE++ + +Q Q K+E + + Q + + R + K + +
Sbjct: 469 QALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPS 528
Query: 580 EKQEW 584
EK W
Sbjct: 529 EKPAW 533
Score = 57.8 bits (138), Expect = 5e-08
Identities = 72/301 (23%), Positives = 127/301 (42%), Gaps = 62/301 (20%)
Query: 534 KKFQQHIQ-----------AQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQ 582
KKFQ I+ A ++ + F+ Q E ++R QLK+ ++ K+K+
Sbjct: 260 KKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI-QLKDHIDRT-----KKKR 313
Query: 583 EWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQ 642
+ + + EEE N L L G L +D +R +L ++
Sbjct: 314 GEKDETEYEYSGSEEEEEENDSGEPSSILNLP----------GESTLRRDFLRLQLANKE 363
Query: 643 TQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRR 702
+ L L +Q +E + + L QK R++ Q E +LE +RRE+ELR+
Sbjct: 364 RSEALRRQQLEQQQRENEEHKRQLLAERQK------RIEEQKEQRRRLEEQQRREKELRK 417
Query: 703 KHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKA-VLKRLK 761
+ E R+ + +E E ++EH+ ++R
Sbjct: 418 QQEREQRRHYEEQMRRE--------------------------EERRRAEHEQEYIRRQL 451
Query: 762 EEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKM 821
EE+ R+L IL +Q H +L + +L+E ++AE L+ QL+QE + L + Q + +
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAE--RLQRQLKQERDYLVSLQHQRQE 509
Query: 822 Q 822
Q
Sbjct: 510 Q 510
Score = 48.9 bits (115), Expect = 2e-05
Identities = 54/243 (22%), Positives = 108/243 (44%), Gaps = 23/243 (9%)
Query: 436 EHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLR 495
E I+ + R ++ + E + SG + ++ + L E R
Sbjct: 295 ERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDF 354
Query: 496 LDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQ 555
L L + + A ++L ++ + E + ++++ +K+ ++ Q +Q++ L E Q
Sbjct: 355 LRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE--QKEQRRRLE---EQQ 409
Query: 556 KREYKLRKEQLKEELNENQSTPKKE--------KQEWLSKQKEN-------IQHFQAEEE 600
+RE +LRK+Q +E+ + ++E +QE++ +Q E +Q E+
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQ 469
Query: 601 ANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQ 660
A LL +R+ LE E R+ +R L + E+D + ++RQ Q+ +E L E M
Sbjct: 470 ALLLEYKRKQLE-EQRQAER--LQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMS 526
Query: 661 ELE 663
E
Sbjct: 527 PSE 529
Score = 44.7 bits (104), Expect = 4e-04
Identities = 36/174 (20%), Positives = 87/174 (50%), Gaps = 24/174 (13%)
Query: 552 LESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYL 611
L +++R LR++QL+++ EN+ + K++ L+++++ I+ Q E+ L +QR+
Sbjct: 359 LANKERSEALRRQQLEQQQRENE----EHKRQLLAERQKRIEE-QKEQRRRLEEQQRREK 413
Query: 612 ELECRRFKRRMLLGRHNLEQDLVREELNKR-------------QTQKDLEHAMLLRQHES 658
EL ++ + + R + E+ + REE +R + Q+ LE HE
Sbjct: 414 ELRKQQEREQ----RRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQ 469
Query: 659 MQELEFRHLNTIQKMRCELI--RLQHQTELTNQLEYNKRRERELRRKHVMEVRQ 710
LE++ ++ + E + +L+ + + L++ ++ +R + +K + ++
Sbjct: 470 ALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKE 523
Score = 42.0 bits (97), Expect = 0.003
Identities = 51/252 (20%), Positives = 112/252 (44%), Gaps = 24/252 (9%)
Query: 629 LEQDLVREELNKRQTQKDLEHAMLLRQ-HESMQELEFR-HLNTIQKMRCELIRLQHQTEL 686
+E LV+ + T++ ++H + Q +E ++ + H++ +K R E +++
Sbjct: 266 IESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSG 325
Query: 687 TNQLE-----------YNKRRERELRRKHV-MEVRQQPKSLKSKELQIKKQFQDTCKIQT 734
+ + E N E LRR + +++ + +S + Q+++Q Q
Sbjct: 326 SEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQ-------QR 378
Query: 735 RQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQ 794
+ R L E + E + +R EEQ R+ L +Q + Q R +E +
Sbjct: 379 ENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERR 438
Query: 795 EAECQ--VLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEE 852
AE + ++ QL++E L Q ++ + + + ++LE++ R + K E +
Sbjct: 439 RAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERD 498
Query: 853 -MLALQNERTER 863
+++LQ++R E+
Sbjct: 499 YLVSLQHQRQEQ 510
Score = 41.2 bits (95), Expect = 0.005
Identities = 49/229 (21%), Positives = 100/229 (43%), Gaps = 17/229 (7%)
Query: 535 KFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNEN---QSTPKKEKQEWLSKQKEN 591
+ + HI +KK E + EY+ + +EE N++ S + L +
Sbjct: 301 QLKDHIDRTKKKRG----EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLR 356
Query: 592 IQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAM 651
+Q E L R+Q + + E KR++L R ++ ++E +R ++
Sbjct: 357 LQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE--QKEQRRRLEEQQRREKE 414
Query: 652 LLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQ 711
L +Q E Q RH + E R +H+ E + ++R+ E+ ++ ++ +
Sbjct: 415 LRKQQEREQR---RHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQAL 471
Query: 712 PKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETT-PKSEHKAVLKR 759
K K+L+ ++Q + ++Q RQ K R++L+ + E + V K+
Sbjct: 472 LLEYKRKQLEEQRQAE---RLQ-RQLKQERDYLVSLQHQRQEQRPVEKK 516
Score = 37.7 bits (86), Expect = 0.054
Identities = 43/197 (21%), Positives = 86/197 (43%), Gaps = 13/197 (6%)
Query: 692 YNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKI-----QTRQYKALRNHLLE 746
+++R E KH +R QP + +Q+K T K +T + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQPNE-RQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 747 TTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQL- 805
E ++L E R+ + + + +E L Q L E Q+ E + K QL
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQL---EQQQRENEEHKRQLL 388
Query: 806 -QQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERI 864
+++ + + + +++ + + ++ELR+ ++R R + + EEE ++E+ E I
Sbjct: 389 AERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQ-EYI 447
Query: 865 RSLLERQAREIEAFDSE 881
R LE + R++E +
Sbjct: 448 RRQLEEEQRQLEILQQQ 464
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 249 bits (637), Expect = 7e-66
Identities = 187/605 (30%), Positives = 301/605 (49%), Gaps = 93/605 (15%)
Query: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
M S + A SL + +++ L DP +F + +G+G++G VY R V+T ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIE-YKGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L++ H +I Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFG 171
+DL++ K L+E IA I L+GL++LH H +IHRDIK N+LLTE +VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SASMASPA----NSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRE 284
L +M+ M AL+ I +N +P L+S +WS F++F++SCL K RP +E+L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----ETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGV 339
+P L D I RTK E D +Y ++G ++EEEEE D G
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYE----------YSG----SEEEEEENDSG- 336
Query: 340 GRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHL 399
+ SS+ +LP S + + ++ S
Sbjct: 337 ------------------------EPSSILNLPGESTLRRDFLRLQ---LANKERSEALR 369
Query: 400 KPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSE 459
+ + E + E + R + ++ K R E ++ ++ E
Sbjct: 370 RQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE---------------EQQRREKE 414
Query: 460 LREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQ 519
LR+Q + RR +++Q+ E + +AE ++ +R + LE ++ ++L+ H+
Sbjct: 415 LRKQQE--REQRRHYEEQMRREEERRRAEHEQEYIR--RQLEEEQRQLEILQQQLL--HE 468
Query: 520 AAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKK 579
A+ E K EE++ + +Q Q K+E + + Q + + R + K + +
Sbjct: 469 QALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPS 528
Query: 580 EKQEW 584
EK W
Sbjct: 529 EKPAW 533
Score = 57.8 bits (138), Expect = 5e-08
Identities = 72/301 (23%), Positives = 127/301 (42%), Gaps = 62/301 (20%)
Query: 534 KKFQQHIQ-----------AQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQ 582
KKFQ I+ A ++ + F+ Q E ++R QLK+ ++ K+K+
Sbjct: 260 KKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI-QLKDHIDRT-----KKKR 313
Query: 583 EWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQ 642
+ + + EEE N L L G L +D +R +L ++
Sbjct: 314 GEKDETEYEYSGSEEEEEENDSGEPSSILNLP----------GESTLRRDFLRLQLANKE 363
Query: 643 TQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRR 702
+ L L +Q +E + + L QK R++ Q E +LE +RRE+ELR+
Sbjct: 364 RSEALRRQQLEQQQRENEEHKRQLLAERQK------RIEEQKEQRRRLEEQQRREKELRK 417
Query: 703 KHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKA-VLKRLK 761
+ E R+ + +E E ++EH+ ++R
Sbjct: 418 QQEREQRRHYEEQMRRE--------------------------EERRRAEHEQEYIRRQL 451
Query: 762 EEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKM 821
EE+ R+L IL +Q H +L + +L+E ++AE L+ QL+QE + L + Q + +
Sbjct: 452 EEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAE--RLQRQLKQERDYLVSLQHQRQE 509
Query: 822 Q 822
Q
Sbjct: 510 Q 510
Score = 48.9 bits (115), Expect = 2e-05
Identities = 54/243 (22%), Positives = 108/243 (44%), Gaps = 23/243 (9%)
Query: 436 EHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLR 495
E I+ + R ++ + E + SG + ++ + L E R
Sbjct: 295 ERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDF 354
Query: 496 LDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQ 555
L L + + A ++L ++ + E + ++++ +K+ ++ Q +Q++ L E Q
Sbjct: 355 LRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE--QKEQRRRLE---EQQ 409
Query: 556 KREYKLRKEQLKEELNENQSTPKKE--------KQEWLSKQKEN-------IQHFQAEEE 600
+RE +LRK+Q +E+ + ++E +QE++ +Q E +Q E+
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQ 469
Query: 601 ANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQ 660
A LL +R+ LE E R+ +R L + E+D + ++RQ Q+ +E L E M
Sbjct: 470 ALLLEYKRKQLE-EQRQAER--LQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMS 526
Query: 661 ELE 663
E
Sbjct: 527 PSE 529
Score = 44.7 bits (104), Expect = 4e-04
Identities = 36/174 (20%), Positives = 87/174 (50%), Gaps = 24/174 (13%)
Query: 552 LESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYL 611
L +++R LR++QL+++ EN+ + K++ L+++++ I+ Q E+ L +QR+
Sbjct: 359 LANKERSEALRRQQLEQQQRENE----EHKRQLLAERQKRIEE-QKEQRRRLEEQQRREK 413
Query: 612 ELECRRFKRRMLLGRHNLEQDLVREELNKR-------------QTQKDLEHAMLLRQHES 658
EL ++ + + R + E+ + REE +R + Q+ LE HE
Sbjct: 414 ELRKQQEREQ----RRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQ 469
Query: 659 MQELEFRHLNTIQKMRCELI--RLQHQTELTNQLEYNKRRERELRRKHVMEVRQ 710
LE++ ++ + E + +L+ + + L++ ++ +R + +K + ++
Sbjct: 470 ALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKE 523
Score = 42.0 bits (97), Expect = 0.003
Identities = 51/252 (20%), Positives = 112/252 (44%), Gaps = 24/252 (9%)
Query: 629 LEQDLVREELNKRQTQKDLEHAMLLRQ-HESMQELEFR-HLNTIQKMRCELIRLQHQTEL 686
+E LV+ + T++ ++H + Q +E ++ + H++ +K R E +++
Sbjct: 266 IESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSG 325
Query: 687 TNQLE-----------YNKRRERELRRKHV-MEVRQQPKSLKSKELQIKKQFQDTCKIQT 734
+ + E N E LRR + +++ + +S + Q+++Q Q
Sbjct: 326 SEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQ-------QR 378
Query: 735 RQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQ 794
+ R L E + E + +R EEQ R+ L +Q + Q R +E +
Sbjct: 379 ENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERR 438
Query: 795 EAECQ--VLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEE 852
AE + ++ QL++E L Q ++ + + + ++LE++ R + K E +
Sbjct: 439 RAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERD 498
Query: 853 -MLALQNERTER 863
+++LQ++R E+
Sbjct: 499 YLVSLQHQRQEQ 510
Score = 41.2 bits (95), Expect = 0.005
Identities = 49/229 (21%), Positives = 100/229 (43%), Gaps = 17/229 (7%)
Query: 535 KFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNEN---QSTPKKEKQEWLSKQKEN 591
+ + HI +KK E + EY+ + +EE N++ S + L +
Sbjct: 301 QLKDHIDRTKKKRG----EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLR 356
Query: 592 IQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAM 651
+Q E L R+Q + + E KR++L R ++ ++E +R ++
Sbjct: 357 LQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE--QKEQRRRLEEQQRREKE 414
Query: 652 LLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQ 711
L +Q E Q RH + E R +H+ E + ++R+ E+ ++ ++ +
Sbjct: 415 LRKQQEREQR---RHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQAL 471
Query: 712 PKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETT-PKSEHKAVLKR 759
K K+L+ ++Q + ++Q RQ K R++L+ + E + V K+
Sbjct: 472 LLEYKRKQLEEQRQAE---RLQ-RQLKQERDYLVSLQHQRQEQRPVEKK 516
Score = 37.7 bits (86), Expect = 0.054
Identities = 43/197 (21%), Positives = 86/197 (43%), Gaps = 13/197 (6%)
Query: 692 YNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKI-----QTRQYKALRNHLLE 746
+++R E KH +R QP + +Q+K T K +T + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQPNE-RQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 747 TTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQL- 805
E ++L E R+ + + + +E L Q L E Q+ E + K QL
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQL---EQQQRENEEHKRQLL 388
Query: 806 -QQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERI 864
+++ + + + +++ + + ++ELR+ ++R R + + EEE ++E+ E I
Sbjct: 389 AERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQ-EYI 447
Query: 865 RSLLERQAREIEAFDSE 881
R LE + R++E +
Sbjct: 448 RRQLEEEQRQLEILQQQ 464
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 246 bits (628), Expect = 8e-65
Identities = 220/918 (23%), Positives = 421/918 (45%), Gaps = 101/918 (11%)
Query: 23 DPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQR 82
DP +++ + E+G G+FG VY A++ T + A K + +S E+ +D I E++ L
Sbjct: 31 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIE---TKSEEELEDYIVEIEILAT 87
Query: 83 IKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVH-KKPLQEVEIAAITHGALQGLAY 141
HP ++ G Y + W+++E+C G A D + + + L E +I + L+ L +
Sbjct: 88 CDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNF 147
Query: 142 LHSHTMIHRDIKAGNILLTEPGQVKLADFG----SASMASPANSFVGTPYWMAPEVIL-- 195
LHS +IHRD+KAGN+L+T G ++LADFG + +SF+GTPYWMAPEV++
Sbjct: 148 LHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCE 207
Query: 196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQS-NEWSDYF 254
M + YD K D+WSLGIT IE+A+ +PP +N M L IA+++ PTL + ++WS F
Sbjct: 208 TMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEF 267
Query: 255 RNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKK 314
R+F+ L K P+ RP++ +LL+H FV L +L+ K V E
Sbjct: 268 RDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVME----------- 316
Query: 315 LLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQS-IPSMSISAS---SQSSSVNS 370
+E +E E++ V T+ + N S + S++A +S S
Sbjct: 317 ----------EIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPL 366
Query: 371 LPDVSDD--KSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRH 428
P S D GD ++ + S + + P EN P R S P S +
Sbjct: 367 APSQSQDSVNEPCSQPSGDRSLQTTSPPV-VAPGNENGLAVPVP-LRKSRPVSMDARIQV 424
Query: 429 KSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAE 488
+ E + A+ +++ + +S E + G K + K +
Sbjct: 425 AQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRD 484
Query: 489 MD------------EHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEK-----------E 525
D L D L + + + + KL KK K
Sbjct: 485 SDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITT 544
Query: 526 AKVMSNEEKKFQQ--HIQAQQKKELNSFLESQKR-------EYKLRKEQLKEELNENQST 576
+K++S +EKK ++ ++ Q+ +EL + + R +++L+ EQ+ + + +
Sbjct: 545 SKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINA 604
Query: 577 PKK---------EKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRH 627
KK E+Q+ +Q E ++ A RR R + + RF+ ++ L +
Sbjct: 605 KKKFFDTELENLERQQ--KQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKK 662
Query: 628 NLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELT 687
++ ++ E+L ++Q ++ ++ M +H ++L R QK EL + T+
Sbjct: 663 EVKNEV--EKLPRQQRKESMKQKM--EEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNR 718
Query: 688 NQLEYNKRRERELRRKHVMEVRQ------QPKSLKSKELQIKKQFQDTCKIQTRQYKALR 741
++ +K RE ++++ ++ R+ + L+ + +K+Q +D +Q +++ LR
Sbjct: 719 REI-CDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQ--RHELLR 775
Query: 742 NHLLETTPKSEH-KAVLKRLKEEQTRKLAIL--AEQYDHSINEMLSTQALRLDEAQEAEC 798
H E + + ++++LK Q ++ A L ++ + + ++L ++ A
Sbjct: 776 KHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAE 835
Query: 799 QVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQN 858
Q + +++Q + Q ++Q + +H+ ++R++ + + L+Q E+ L
Sbjct: 836 Q--REKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVE 893
Query: 859 ERTERIRSLLERQAREIE 876
T+++++L E + ++
Sbjct: 894 HETQKLKALDESHNQNLK 911
Score = 88.2 bits (217), Expect = 4e-17
Identities = 92/442 (20%), Positives = 209/442 (47%), Gaps = 55/442 (12%)
Query: 440 TIRTASLVTRQMQEHEQDSELREQ-MSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDK 498
+I T+ +++ ++ E+ LR Q + + ++++ + L NK + ++++ R ++
Sbjct: 541 SITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQ 600
Query: 499 DLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKRE 558
++ ++ F E+E L ++ + +EK + + ++ + I+ +Q ++ F E +
Sbjct: 601 EINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQE----Q 656
Query: 559 YKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEE--EANLLRRQRQYLELECR 616
KL K+++K NE + P+++++E + ++ E +H Q ++ + + + +Q++ LEL +
Sbjct: 657 LKLMKKEVK---NEVEKLPRQQRKESMKQKME--EHTQKKQLLDRDFVAKQKEDLELAMK 711
Query: 617 RF---KRRMLLGRHNLEQDLVREELNKRQTQ-KDLEHAMLLRQHESMQELEFRHLNTIQK 672
R RR + D RE L K+Q +D E A+ + +QE RH Q+
Sbjct: 712 RLTTDNRREIC-------DKERECLMKKQELLRDREAALWEMEEHQLQE---RHQLVKQQ 761
Query: 673 M-------RCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQ 725
+ R EL+R +H+ E YN+R +L+ + E + PK +S+
Sbjct: 762 LKDQYFLQRHELLR-KHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAM 820
Query: 726 FQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLST 785
++ + I A + ++ + E K R K E+ ++ +++++ + +ML+
Sbjct: 821 YKKSLHINGGGSAAEQREKIKQFSQQEEK----RQKSERLQQ----QQKHENQMRDMLAQ 872
Query: 786 QALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALL 845
+ E Q+ + + + ++ E + L A + H++ L+E ++ R+ L
Sbjct: 873 CESNMSELQQLQNEKCHLLVEHETQKLKAL--------DESHNQNLKEWRDKLRPRKKAL 924
Query: 846 EQ-----KIEEEMLALQNERTE 862
E+ K E+EM +E E
Sbjct: 925 EEDLNQKKREQEMFFKLSEEAE 946
Score = 33.5 bits (75), Expect = 1.0
Identities = 67/360 (18%), Positives = 134/360 (37%), Gaps = 45/360 (12%)
Query: 255 RNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKK 314
+ F D+ L+ + + + E ++ +R R E I L ++ +D R + L+ MKK
Sbjct: 606 KKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRL-EQDRDYTRFQEQLKL--MKK 662
Query: 315 LLFQEAHNGPAVEAQE--EEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLP 372
+ E P + +E +++ ++H + + Q + + + + ++
Sbjct: 663 EVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQK---EDLELAMKRLTTDNRR 719
Query: 373 DVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDP---QSPPQVSRHK 429
++ D + E +M+ + + + E + + + D Q + +H+
Sbjct: 720 EICDKEREC-LMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHE 778
Query: 430 SHYRNREHFATIRTASLVTRQMQEHE-----QDSELREQMSGYKRM-----------RRQ 473
+ + L RQ QE Q SE + +M+ YK+ +R+
Sbjct: 779 KEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQRE 838
Query: 474 HQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEK--------------LIKKHQ 519
KQ E K RL+ + E Q + A+ E L+ +H+
Sbjct: 839 KIKQFSQQEEK---RQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHE 895
Query: 520 AAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKK 579
K N+ K + +KK L L +KRE ++ + +E N STP K
Sbjct: 896 TQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSK 955
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 240 bits (613), Expect = 4e-63
Identities = 165/482 (34%), Positives = 243/482 (50%), Gaps = 52/482 (10%)
Query: 22 EDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQ 81
+ PE++F L ++G GS+G+VY A T ++VAIK++ Q+IIKE+ +Q
Sbjct: 24 KQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDL-----QEIIKEISIMQ 78
Query: 82 RIKHPNSIEYKGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAITHGALQGLA 140
+ P+ ++Y G Y + W+VMEYC GS SD++ + K L E EIA I L+GL
Sbjct: 79 QCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLE 138
Query: 141 YLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVILA 196
YLH IHRDIKAGNILL G KLADFG A + N+ +GTP+WMAPEVI
Sbjct: 139 YLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-- 196
Query: 197 MDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNE-WSDYFR 255
E Y+ D+WSLGIT IE+AE KPP +++ M A++ I N PT + E WSD F
Sbjct: 197 -QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFT 255
Query: 256 NFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKL 315
+FV CL K P+ R T+ +LL+H FV + ++L DLI D K+K+
Sbjct: 256 DFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDV----------KLKRQ 305
Query: 316 LFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVS 375
Q+ E EE+E D G V +VG + AS+ + N+
Sbjct: 306 ESQQREVDQDDEENSEEDEMDSGT----MVRAVGDEMGTVRV---ASTMTDGANT----- 353
Query: 376 DDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNR 435
M+E D T+ S + + E+E EEG + R D P ++ +
Sbjct: 354 -------MIEHDDTLPSQLGTMVINAEDE--EEEGTMKRR--DETMQPAKPSFLEYFEQK 402
Query: 436 EHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMR----RQHQKQLMTLENKLKAEMDE 491
E I + ++ D ++ Q Y+ ++ QK+L+ L+ ++ E++E
Sbjct: 403 EKENQINSFGKSVPGPLKNSSDWKI-PQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEE 461
Query: 492 HR 493
R
Sbjct: 462 IR 463
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 239 bits (609), Expect = 1e-62
Identities = 192/632 (30%), Positives = 310/632 (49%), Gaps = 88/632 (13%)
Query: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
M S + A SL + +++ L DP +F + +G+G++G VY R V+T ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIE-YKGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L++ H +I Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFG 171
+DL++ K L+E IA I L+GL++LH H +IHRDIK N+LLTE +VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SASMASPA----NSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRE 284
L +M+ M AL+ I +N +P L+S +WS F++F++SCL K RP +E+L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----ETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGV 339
+P L D I RTK E D +Y ++G ++EEEEE D G
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYE----------YSG----SEEEEEENDSG- 336
Query: 340 GRTGTVNSVGSN---QSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSV 396
+ +N G + + + ++ +S ++ + +L+ + ++
Sbjct: 337 EPSSILNLPGESTLRRDFLRLQLANKERSEALR--------RQQLEQQQRENEEHKRQL- 387
Query: 397 IHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQ 456
L ++ E+ + R R + Q + R + R H+ + E+
Sbjct: 388 --LAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHY----------EEQMRREE 435
Query: 457 DSELREQMSGYKRMRRQHQKQLMTLENKLKAEMD-----EHRLRLDKDLETQRNNFAAEM 511
+ E YKR + + Q+Q L+ +LK E D +H+ + + +E +
Sbjct: 436 ERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVE--KKPLYHYK 493
Query: 512 EKLIKKHQAAMEKE-----AKVMSNEEKKFQQHIQAQQKKELNSFLES-QKREYKLR-KE 564
E + + A KE A Q + Q K L+ F E+ +++
Sbjct: 494 EGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPR 553
Query: 565 QLKEELNENQSTP----KKEKQEWLSKQKENI 592
Q + +EN P K ++ WL +Q+E+I
Sbjct: 554 QNSDPTSENPPLPTRIEKFDRSSWL-RQEEDI 584
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/228 (19%), Positives = 97/228 (42%), Gaps = 22/228 (9%)
Query: 436 EHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLR 495
E I+ + R ++ + E + SG + ++ + L E R
Sbjct: 295 ERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDF 354
Query: 496 LDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQ 555
L L + + A ++L ++ + E + ++++ +K+ ++ Q +Q++ L E Q
Sbjct: 355 LRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE--QKEQRRRLE---EQQ 409
Query: 556 KREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELEC 615
+RE +LRK+Q +E+ + ++E++ ++ ++ + Q EE+ R QRQ +
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQ--- 466
Query: 616 RRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELE 663
E+D + ++RQ Q+ +E L E M E
Sbjct: 467 --------------ERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSE 500
Score = 42.4 bits (98), Expect = 0.002
Identities = 33/136 (24%), Positives = 64/136 (47%), Gaps = 1/136 (0%)
Query: 657 ESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLK 716
ES +F L K R E +R Q + + E +KR+ R+K + E ++Q + L+
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE 406
Query: 717 SKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYD 776
++ + K+ + + Q R Y+ + E ++EH+ KR + E+ R+ L Q
Sbjct: 407 EQQRREKELRKQQEREQRRHYEE-QMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLK 465
Query: 777 HSINEMLSTQALRLDE 792
+ ++S Q R ++
Sbjct: 466 QERDYLVSLQHQRQEQ 481
Score = 41.6 bits (96), Expect = 0.004
Identities = 52/230 (22%), Positives = 103/230 (44%), Gaps = 30/230 (13%)
Query: 448 TRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNF 507
T Q+ +H +R+Q + +R R K + K + E DE E + N
Sbjct: 280 TEQLMKHPF---IRDQPN--ERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEND 334
Query: 508 AAEMEKLIK-KHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQL 566
+ E ++ ++ + ++ + K+ + ++ QQ LE Q+RE + K QL
Sbjct: 335 SGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ-------LEQQQRENEEHKRQL 387
Query: 567 KEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGR 626
E + + +KE++ L +Q+ + + ++E R QR++ E + RR + R R
Sbjct: 388 LAE-RQKRIEEQKEQRRRLEEQQRREKELRKQQE----REQRRHYEEQMRREEERR---R 439
Query: 627 HNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCE 676
EQ+ R++L +++ + L Q + QE ++ L ++Q R E
Sbjct: 440 AEHEQEYKRKQLEEQRQAERL-------QRQLKQERDY--LVSLQHQRQE 480
Score = 41.2 bits (95), Expect = 0.005
Identities = 58/247 (23%), Positives = 112/247 (45%), Gaps = 43/247 (17%)
Query: 629 LEQDLVREELNKRQTQKDLEHAMLLRQ-HESMQELEFR-HLNTIQKMRCELIRLQHQTEL 686
+E LV+ + T++ ++H + Q +E ++ + H++ +K R E + +TE
Sbjct: 266 IESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE----KDETEY 321
Query: 687 TNQLEYNKRRERELRRKHVMEVRQQPKSLKSK--ELQIKKQFQDTCKIQTRQYKALRNHL 744
EY+ E E +P S+ + E +++ F + +ALR
Sbjct: 322 ----EYSGSEEEEEENDS-----GEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ 372
Query: 745 LETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQ 804
LE ++ +E + K +LAE+ E Q RL+E Q E ++ K
Sbjct: 373 LE-----------QQQRENEEHKRQLLAERQKRI--EEQKEQRRRLEEQQRREKELRK-- 417
Query: 805 LQQELELLNAYQSKIKMQAE---AQHDRE-----LRELEQRVSLRRALLEQKIEEEMLAL 856
QQE E Y+ +++ + E A+H++E L E Q L+R L +++ + +++L
Sbjct: 418 -QQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQER--DYLVSL 474
Query: 857 QNERTER 863
Q++R E+
Sbjct: 475 QHQRQEQ 481
Score = 33.1 bits (74), Expect = 1.3
Identities = 41/193 (21%), Positives = 84/193 (43%), Gaps = 13/193 (6%)
Query: 692 YNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKI-----QTRQYKALRNHLLE 746
+++R E KH +R QP + +Q+K T K +T + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQPNE-RQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 747 TTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQL- 805
E ++L E R+ + + + +E L Q L E Q+ E + K QL
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQL---EQQQRENEEHKRQLL 388
Query: 806 -QQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERI 864
+++ + + + +++ + + ++ELR+ ++R R + + EEE ++E+ +
Sbjct: 389 AERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKR 448
Query: 865 RSLLE-RQAREIE 876
+ L E RQA ++
Sbjct: 449 KQLEEQRQAERLQ 461
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 239 bits (609), Expect = 1e-62
Identities = 192/632 (30%), Positives = 310/632 (49%), Gaps = 88/632 (13%)
Query: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
M S + A SL + +++ L DP +F + +G+G++G VY R V+T ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIE-YKGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L++ H +I Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFG 171
+DL++ K L+E IA I L+GL++LH H +IHRDIK N+LLTE +VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SASMASPA----NSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRE 284
L +M+ M AL+ I +N +P L+S +WS F++F++SCL K RP +E+L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----ETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGV 339
+P L D I RTK E D +Y ++G ++EEEEE D G
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYE----------YSG----SEEEEEENDSG- 336
Query: 340 GRTGTVNSVGSN---QSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSV 396
+ +N G + + + ++ +S ++ + +L+ + ++
Sbjct: 337 EPSSILNLPGESTLRRDFLRLQLANKERSEALR--------RQQLEQQQRENEEHKRQL- 387
Query: 397 IHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQ 456
L ++ E+ + R R + Q + R + R H+ + E+
Sbjct: 388 --LAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHY----------EEQMRREE 435
Query: 457 DSELREQMSGYKRMRRQHQKQLMTLENKLKAEMD-----EHRLRLDKDLETQRNNFAAEM 511
+ E YKR + + Q+Q L+ +LK E D +H+ + + +E +
Sbjct: 436 ERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVE--KKPLYHYK 493
Query: 512 EKLIKKHQAAMEKE-----AKVMSNEEKKFQQHIQAQQKKELNSFLES-QKREYKLR-KE 564
E + + A KE A Q + Q K L+ F E+ +++
Sbjct: 494 EGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPR 553
Query: 565 QLKEELNENQSTP----KKEKQEWLSKQKENI 592
Q + +EN P K ++ WL +Q+E+I
Sbjct: 554 QNSDPTSENPPLPTRIEKFDRSSWL-RQEEDI 584
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/228 (19%), Positives = 97/228 (42%), Gaps = 22/228 (9%)
Query: 436 EHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLR 495
E I+ + R ++ + E + SG + ++ + L E R
Sbjct: 295 ERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDF 354
Query: 496 LDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQ 555
L L + + A ++L ++ + E + ++++ +K+ ++ Q +Q++ L E Q
Sbjct: 355 LRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE--QKEQRRRLE---EQQ 409
Query: 556 KREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELEC 615
+RE +LRK+Q +E+ + ++E++ ++ ++ + Q EE+ R QRQ +
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQ--- 466
Query: 616 RRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELE 663
E+D + ++RQ Q+ +E L E M E
Sbjct: 467 --------------ERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSE 500
Score = 42.4 bits (98), Expect = 0.002
Identities = 33/136 (24%), Positives = 64/136 (47%), Gaps = 1/136 (0%)
Query: 657 ESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLK 716
ES +F L K R E +R Q + + E +KR+ R+K + E ++Q + L+
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE 406
Query: 717 SKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYD 776
++ + K+ + + Q R Y+ + E ++EH+ KR + E+ R+ L Q
Sbjct: 407 EQQRREKELRKQQEREQRRHYEE-QMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLK 465
Query: 777 HSINEMLSTQALRLDE 792
+ ++S Q R ++
Sbjct: 466 QERDYLVSLQHQRQEQ 481
Score = 41.6 bits (96), Expect = 0.004
Identities = 52/230 (22%), Positives = 103/230 (44%), Gaps = 30/230 (13%)
Query: 448 TRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNF 507
T Q+ +H +R+Q + +R R K + K + E DE E + N
Sbjct: 280 TEQLMKHPF---IRDQPN--ERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEND 334
Query: 508 AAEMEKLIK-KHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQL 566
+ E ++ ++ + ++ + K+ + ++ QQ LE Q+RE + K QL
Sbjct: 335 SGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ-------LEQQQRENEEHKRQL 387
Query: 567 KEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGR 626
E + + +KE++ L +Q+ + + ++E R QR++ E + RR + R R
Sbjct: 388 LAE-RQKRIEEQKEQRRRLEEQQRREKELRKQQE----REQRRHYEEQMRREEERR---R 439
Query: 627 HNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCE 676
EQ+ R++L +++ + L Q + QE ++ L ++Q R E
Sbjct: 440 AEHEQEYKRKQLEEQRQAERL-------QRQLKQERDY--LVSLQHQRQE 480
Score = 41.2 bits (95), Expect = 0.005
Identities = 58/247 (23%), Positives = 112/247 (45%), Gaps = 43/247 (17%)
Query: 629 LEQDLVREELNKRQTQKDLEHAMLLRQ-HESMQELEFR-HLNTIQKMRCELIRLQHQTEL 686
+E LV+ + T++ ++H + Q +E ++ + H++ +K R E + +TE
Sbjct: 266 IESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE----KDETEY 321
Query: 687 TNQLEYNKRRERELRRKHVMEVRQQPKSLKSK--ELQIKKQFQDTCKIQTRQYKALRNHL 744
EY+ E E +P S+ + E +++ F + +ALR
Sbjct: 322 ----EYSGSEEEEEENDS-----GEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ 372
Query: 745 LETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQ 804
LE ++ +E + K +LAE+ E Q RL+E Q E ++ K
Sbjct: 373 LE-----------QQQRENEEHKRQLLAERQKRI--EEQKEQRRRLEEQQRREKELRK-- 417
Query: 805 LQQELELLNAYQSKIKMQAE---AQHDRE-----LRELEQRVSLRRALLEQKIEEEMLAL 856
QQE E Y+ +++ + E A+H++E L E Q L+R L +++ + +++L
Sbjct: 418 -QQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQER--DYLVSL 474
Query: 857 QNERTER 863
Q++R E+
Sbjct: 475 QHQRQEQ 481
Score = 33.1 bits (74), Expect = 1.3
Identities = 41/193 (21%), Positives = 84/193 (43%), Gaps = 13/193 (6%)
Query: 692 YNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKI-----QTRQYKALRNHLLE 746
+++R E KH +R QP + +Q+K T K +T + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQPNE-RQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 747 TTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQL- 805
E ++L E R+ + + + +E L Q L E Q+ E + K QL
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQL---EQQQRENEEHKRQLL 388
Query: 806 -QQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERI 864
+++ + + + +++ + + ++ELR+ ++R R + + EEE ++E+ +
Sbjct: 389 AERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKR 448
Query: 865 RSLLE-RQAREIE 876
+ L E RQA ++
Sbjct: 449 KQLEEQRQAERLQ 461
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 238 bits (608), Expect = 2e-62
Identities = 157/433 (36%), Positives = 235/433 (54%), Gaps = 47/433 (10%)
Query: 14 EIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDI 73
+++E + PE++F L ++G GS+G+V+ A + +VVAIK++ Q+I
Sbjct: 13 KLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDL-----QEI 67
Query: 74 IKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAIT 132
IKE+ +Q+ P ++Y G Y + W+VMEYC GS SD++ + K L E EIA I
Sbjct: 68 IKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATIL 127
Query: 133 HGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYW 188
L+GL YLH IHRDIKAGNILL G KLADFG A + N+ +GTP+W
Sbjct: 128 KSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFW 187
Query: 189 MAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSN 248
MAPEVI E Y+ D+WSLGIT IE+AE KPP +++ M A++ I N PT +
Sbjct: 188 MAPEVI---QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKP 244
Query: 249 E-WSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNL 307
E WSD F +FV CL K P+ R T+ +LL+H F+ +P ++L DLI E+
Sbjct: 245 ELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITE----AMEIKAK 300
Query: 308 QYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQSSS 367
++ + ++ L +E N +E+E H + +T +V SVG+ ++ +MS A +
Sbjct: 301 RHEEQQRELEEEEEN------SDEDELDSHTMVKT-SVESVGTMRATSTMSEGAQTMIEH 353
Query: 368 VNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQ-SPPQVS 426
++ M+E D M VI+ + EEE E+G + A+ PQ P
Sbjct: 354 NST------------MLESDLGTM----VINSEDEEE---EDGTMKRNATSPQVQRPSFM 394
Query: 427 RH--KSHYRNREH 437
+ K ++N+ H
Sbjct: 395 DYFDKQDFKNKSH 407
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 238 bits (607), Expect = 2e-62
Identities = 169/514 (32%), Positives = 266/514 (51%), Gaps = 69/514 (13%)
Query: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
M S + A SL + +++ L DP +F + +G+G++G VY R V+T ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIE-YKGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L++ H +I Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFG 171
+DL++ K L+E IA I L+GL++LH H +IHRDIK N+LLTE +VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SASMASPA----NSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRE 284
L +M+ M AL+ I +N +P L+S +WS F++F++SCL K RP +E+L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----ETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGV 339
+P L D I RTK E D +Y ++G ++EEEEE D G
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYE----------YSG----SEEEEEENDSG- 336
Query: 340 GRTGTVNSVGSN---QSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSV 396
+ +N G + + + ++ +S ++ + +L+ + ++
Sbjct: 337 EPSSILNLPGESTLRRDFLRLQLANKERSEALR--------RQQLEQQQRENEEHKRQL- 387
Query: 397 IHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQ 456
L ++ E+ + R R + Q + R + R H+ + E+
Sbjct: 388 --LAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHY----------EEQMRREE 435
Query: 457 DSELREQMSGYKRMRRQHQKQLMTLENKLKAEMD 490
+ E YKR + + Q+Q L+ +LK E D
Sbjct: 436 ERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERD 469
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/195 (21%), Positives = 84/195 (43%), Gaps = 11/195 (5%)
Query: 407 REEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSG 466
++E + S+ + S S N +T+R L + + ++ R+Q+
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375
Query: 467 YKRMRRQHQKQLMTLENKLKAEMDEHRLRLD------KDLETQ-----RNNFAAEMEKLI 515
+R +H++QL+ K E E R RL+ K+L Q R ++ +M +
Sbjct: 376 QQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREE 435
Query: 516 KKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQS 575
++ +A E+E K EE++ + +Q Q K+E + + Q + + R + K + +
Sbjct: 436 ERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEG 495
Query: 576 TPKKEKQEWLSKQKE 590
EK W + +E
Sbjct: 496 MSPSEKPAWAKEVEE 510
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/228 (19%), Positives = 97/228 (42%), Gaps = 22/228 (9%)
Query: 436 EHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLR 495
E I+ + R ++ + E + SG + ++ + L E R
Sbjct: 295 ERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDF 354
Query: 496 LDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQ 555
L L + + A ++L ++ + E + ++++ +K+ ++ Q +Q++ L E Q
Sbjct: 355 LRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE--QKEQRRRLE---EQQ 409
Query: 556 KREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELEC 615
+RE +LRK+Q +E+ + ++E++ ++ ++ + Q EE+ R QRQ +
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQ--- 466
Query: 616 RRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELE 663
E+D + ++RQ Q+ +E L E M E
Sbjct: 467 --------------ERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSE 500
Score = 42.4 bits (98), Expect = 0.002
Identities = 33/136 (24%), Positives = 64/136 (47%), Gaps = 1/136 (0%)
Query: 657 ESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLK 716
ES +F L K R E +R Q + + E +KR+ R+K + E ++Q + L+
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE 406
Query: 717 SKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYD 776
++ + K+ + + Q R Y+ + E ++EH+ KR + E+ R+ L Q
Sbjct: 407 EQQRREKELRKQQEREQRRHYEE-QMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLK 465
Query: 777 HSINEMLSTQALRLDE 792
+ ++S Q R ++
Sbjct: 466 QERDYLVSLQHQRQEQ 481
Score = 41.6 bits (96), Expect = 0.004
Identities = 52/230 (22%), Positives = 103/230 (44%), Gaps = 30/230 (13%)
Query: 448 TRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNF 507
T Q+ +H +R+Q + +R R K + K + E DE E + N
Sbjct: 280 TEQLMKHPF---IRDQPN--ERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEND 334
Query: 508 AAEMEKLIK-KHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQL 566
+ E ++ ++ + ++ + K+ + ++ QQ LE Q+RE + K QL
Sbjct: 335 SGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ-------LEQQQRENEEHKRQL 387
Query: 567 KEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGR 626
E + + +KE++ L +Q+ + + ++E R QR++ E + RR + R R
Sbjct: 388 LAE-RQKRIEEQKEQRRRLEEQQRREKELRKQQE----REQRRHYEEQMRREEERR---R 439
Query: 627 HNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCE 676
EQ+ R++L +++ + L Q + QE ++ L ++Q R E
Sbjct: 440 AEHEQEYKRKQLEEQRQAERL-------QRQLKQERDY--LVSLQHQRQE 480
Score = 41.2 bits (95), Expect = 0.005
Identities = 58/247 (23%), Positives = 112/247 (45%), Gaps = 43/247 (17%)
Query: 629 LEQDLVREELNKRQTQKDLEHAMLLRQ-HESMQELEFR-HLNTIQKMRCELIRLQHQTEL 686
+E LV+ + T++ ++H + Q +E ++ + H++ +K R E + +TE
Sbjct: 266 IESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE----KDETEY 321
Query: 687 TNQLEYNKRRERELRRKHVMEVRQQPKSLKSK--ELQIKKQFQDTCKIQTRQYKALRNHL 744
EY+ E E +P S+ + E +++ F + +ALR
Sbjct: 322 ----EYSGSEEEEEENDS-----GEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ 372
Query: 745 LETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQ 804
LE ++ +E + K +LAE+ E Q RL+E Q E ++ K
Sbjct: 373 LE-----------QQQRENEEHKRQLLAERQKRI--EEQKEQRRRLEEQQRREKELRK-- 417
Query: 805 LQQELELLNAYQSKIKMQAE---AQHDRE-----LRELEQRVSLRRALLEQKIEEEMLAL 856
QQE E Y+ +++ + E A+H++E L E Q L+R L +++ + +++L
Sbjct: 418 -QQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQER--DYLVSL 474
Query: 857 QNERTER 863
Q++R E+
Sbjct: 475 QHQRQEQ 481
Score = 33.1 bits (74), Expect = 1.3
Identities = 41/193 (21%), Positives = 84/193 (43%), Gaps = 13/193 (6%)
Query: 692 YNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKI-----QTRQYKALRNHLLE 746
+++R E KH +R QP + +Q+K T K +T + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQPNE-RQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 747 TTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQL- 805
E ++L E R+ + + + +E L Q L E Q+ E + K QL
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQL---EQQQRENEEHKRQLL 388
Query: 806 -QQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERI 864
+++ + + + +++ + + ++ELR+ ++R R + + EEE ++E+ +
Sbjct: 389 AERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKR 448
Query: 865 RSLLE-RQAREIE 876
+ L E RQA ++
Sbjct: 449 KQLEEQRQAERLQ 461
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 238 bits (607), Expect = 2e-62
Identities = 169/514 (32%), Positives = 266/514 (51%), Gaps = 69/514 (13%)
Query: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
M S + A SL + +++ L DP +F + +G+G++G VY R V+T ++ AIK M
Sbjct: 1 MASDSPARSLDEIDLSAL---RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIE-YKGCYLREHTA------WLVMEYC-LGSA 112
+G + E I +E+ L++ H +I Y G +++++ WLVME+C GS
Sbjct: 58 VTGDEEEE----IKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 113
Query: 113 SDLLEVHK-KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFG 171
+DL++ K L+E IA I L+GL++LH H +IHRDIK N+LLTE +VKL DFG
Sbjct: 114 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SASMASPA----NSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ N+F+GTPYWMAPEVI A DE YD K D+WSLGIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRE 284
L +M+ M AL+ I +N +P L+S +WS F++F++SCL K RP +E+L+KH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-RD 291
Query: 285 RP-----ETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGV 339
+P L D I RTK E D +Y ++G ++EEEEE D G
Sbjct: 292 QPNERQVRIQLKDHIDRTKKKRGEKDETEYE----------YSG----SEEEEEENDSG- 336
Query: 340 GRTGTVNSVGSN---QSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSV 396
+ +N G + + + ++ +S ++ + +L+ + ++
Sbjct: 337 EPSSILNLPGESTLRRDFLRLQLANKERSEALR--------RQQLEQQQRENEEHKRQL- 387
Query: 397 IHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQ 456
L ++ E+ + R R + Q + R + R H+ + E+
Sbjct: 388 --LAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHY----------EEQMRREE 435
Query: 457 DSELREQMSGYKRMRRQHQKQLMTLENKLKAEMD 490
+ E YKR + + Q+Q L+ +LK E D
Sbjct: 436 ERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERD 469
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/195 (21%), Positives = 84/195 (43%), Gaps = 11/195 (5%)
Query: 407 REEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSG 466
++E + S+ + S S N +T+R L + + ++ R+Q+
Sbjct: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375
Query: 467 YKRMRRQHQKQLMTLENKLKAEMDEHRLRLD------KDLETQ-----RNNFAAEMEKLI 515
+R +H++QL+ K E E R RL+ K+L Q R ++ +M +
Sbjct: 376 QQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREE 435
Query: 516 KKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQS 575
++ +A E+E K EE++ + +Q Q K+E + + Q + + R + K + +
Sbjct: 436 ERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEG 495
Query: 576 TPKKEKQEWLSKQKE 590
EK W + +E
Sbjct: 496 MSPSEKPAWAKEVEE 510
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/228 (19%), Positives = 97/228 (42%), Gaps = 22/228 (9%)
Query: 436 EHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLR 495
E I+ + R ++ + E + SG + ++ + L E R
Sbjct: 295 ERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDF 354
Query: 496 LDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQ 555
L L + + A ++L ++ + E + ++++ +K+ ++ Q +Q++ L E Q
Sbjct: 355 LRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEE--QKEQRRRLE---EQQ 409
Query: 556 KREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELEC 615
+RE +LRK+Q +E+ + ++E++ ++ ++ + Q EE+ R QRQ +
Sbjct: 410 RREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQ--- 466
Query: 616 RRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELE 663
E+D + ++RQ Q+ +E L E M E
Sbjct: 467 --------------ERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSE 500
Score = 42.4 bits (98), Expect = 0.002
Identities = 33/136 (24%), Positives = 64/136 (47%), Gaps = 1/136 (0%)
Query: 657 ESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLK 716
ES +F L K R E +R Q + + E +KR+ R+K + E ++Q + L+
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLE 406
Query: 717 SKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYD 776
++ + K+ + + Q R Y+ + E ++EH+ KR + E+ R+ L Q
Sbjct: 407 EQQRREKELRKQQEREQRRHYEE-QMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLK 465
Query: 777 HSINEMLSTQALRLDE 792
+ ++S Q R ++
Sbjct: 466 QERDYLVSLQHQRQEQ 481
Score = 41.6 bits (96), Expect = 0.004
Identities = 52/230 (22%), Positives = 103/230 (44%), Gaps = 30/230 (13%)
Query: 448 TRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNF 507
T Q+ +H +R+Q + +R R K + K + E DE E + N
Sbjct: 280 TEQLMKHPF---IRDQPN--ERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEND 334
Query: 508 AAEMEKLIK-KHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQL 566
+ E ++ ++ + ++ + K+ + ++ QQ LE Q+RE + K QL
Sbjct: 335 SGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ-------LEQQQRENEEHKRQL 387
Query: 567 KEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGR 626
E + + +KE++ L +Q+ + + ++E R QR++ E + RR + R R
Sbjct: 388 LAE-RQKRIEEQKEQRRRLEEQQRREKELRKQQE----REQRRHYEEQMRREEERR---R 439
Query: 627 HNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCE 676
EQ+ R++L +++ + L Q + QE ++ L ++Q R E
Sbjct: 440 AEHEQEYKRKQLEEQRQAERL-------QRQLKQERDY--LVSLQHQRQE 480
Score = 41.2 bits (95), Expect = 0.005
Identities = 58/247 (23%), Positives = 112/247 (45%), Gaps = 43/247 (17%)
Query: 629 LEQDLVREELNKRQTQKDLEHAMLLRQ-HESMQELEFR-HLNTIQKMRCELIRLQHQTEL 686
+E LV+ + T++ ++H + Q +E ++ + H++ +K R E + +TE
Sbjct: 266 IESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE----KDETEY 321
Query: 687 TNQLEYNKRRERELRRKHVMEVRQQPKSLKSK--ELQIKKQFQDTCKIQTRQYKALRNHL 744
EY+ E E +P S+ + E +++ F + +ALR
Sbjct: 322 ----EYSGSEEEEEENDS-----GEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQ 372
Query: 745 LETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQ 804
LE ++ +E + K +LAE+ E Q RL+E Q E ++ K
Sbjct: 373 LE-----------QQQRENEEHKRQLLAERQKRI--EEQKEQRRRLEEQQRREKELRK-- 417
Query: 805 LQQELELLNAYQSKIKMQAE---AQHDRE-----LRELEQRVSLRRALLEQKIEEEMLAL 856
QQE E Y+ +++ + E A+H++E L E Q L+R L +++ + +++L
Sbjct: 418 -QQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQER--DYLVSL 474
Query: 857 QNERTER 863
Q++R E+
Sbjct: 475 QHQRQEQ 481
Score = 33.1 bits (74), Expect = 1.3
Identities = 41/193 (21%), Positives = 84/193 (43%), Gaps = 13/193 (6%)
Query: 692 YNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKI-----QTRQYKALRNHLLE 746
+++R E KH +R QP + +Q+K T K +T + E
Sbjct: 274 HSQRPATEQLMKHPF-IRDQPNE-RQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEE 331
Query: 747 TTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQL- 805
E ++L E R+ + + + +E L Q L E Q+ E + K QL
Sbjct: 332 ENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQL---EQQQRENEEHKRQLL 388
Query: 806 -QQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERI 864
+++ + + + +++ + + ++ELR+ ++R R + + EEE ++E+ +
Sbjct: 389 AERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKR 448
Query: 865 RSLLE-RQAREIE 876
+ L E RQA ++
Sbjct: 449 KQLEEQRQAERLQ 461
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 237 bits (604), Expect = 5e-62
Identities = 137/284 (48%), Positives = 181/284 (63%), Gaps = 14/284 (4%)
Query: 21 KEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFL 80
K DPE+LFT L +IG GSFG V+ D RT +VVAIK + +++ ++ +DI +E+ L
Sbjct: 17 KADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDL--EEAEDEIEDIQQEITVL 74
Query: 81 QRIKHPNSIEYKGCYLREHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAITHGALQGL 139
+ P +Y G YL++ W++MEY G SA DLLE PL E +IA I L+GL
Sbjct: 75 SQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE--PGPLDETQIATILREILKGL 132
Query: 140 AYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVIL 195
YLHS IHRDIKA N+LL+E G+VKLADFG A + N+FVGTP+WMAPEVI
Sbjct: 133 DYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI- 191
Query: 196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFR 255
+ YD K D+WSLGIT IELA +PP ++ M L+ I +N PTL+ N +S +
Sbjct: 192 --KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN-YSKPLK 248
Query: 256 NFVDSCLQKIPQDRPTSEELLKHIFVLRERPET-VLIDLIQRTK 298
FV++CL K P RPT++ELLKH F+LR +T L +LI R K
Sbjct: 249 EFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYK 292
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 237 bits (604), Expect = 5e-62
Identities = 137/284 (48%), Positives = 181/284 (63%), Gaps = 14/284 (4%)
Query: 21 KEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFL 80
K DPE+LFT L +IG GSFG V+ D RT +VVAIK + +++ ++ +DI +E+ L
Sbjct: 29 KADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDL--EEAEDEIEDIQQEITVL 86
Query: 81 QRIKHPNSIEYKGCYLREHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAITHGALQGL 139
+ P +Y G YL++ W++MEY G SA DLLE PL E +IA I L+GL
Sbjct: 87 SQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE--PGPLDETQIATILREILKGL 144
Query: 140 AYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVIL 195
YLHS IHRDIKA N+LL+E G+VKLADFG A + N+FVGTP+WMAPEVI
Sbjct: 145 DYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI- 203
Query: 196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFR 255
+ YD K D+WSLGIT IELA +PP ++ M L+ I +N PTL+ N +S +
Sbjct: 204 --KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN-YSKPLK 260
Query: 256 NFVDSCLQKIPQDRPTSEELLKHIFVLRERPET-VLIDLIQRTK 298
FV++CL K P RPT++ELLKH F+LR +T L +LI R K
Sbjct: 261 EFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYK 304
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 231 bits (590), Expect = 2e-60
Identities = 185/625 (29%), Positives = 309/625 (49%), Gaps = 83/625 (13%)
Query: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
M + + A SL D +++ L DP +F + +G+G++G VY R V+T ++ AIK M
Sbjct: 1 MANDSPAKSLVDIDLSSL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIE-YKGCYLR------EHTAWLVMEYC-LGSA 112
+ + E I E+ L++ H +I Y G +++ + WLVME+C GS
Sbjct: 58 VTEDEEEE----IKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSI 113
Query: 113 SDLLEVHK-KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFG 171
+DL++ K L+E IA I+ L+GLA+LH H +IHRDIK N+LLTE +VKL DFG
Sbjct: 114 TDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SASMASPA----NSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ N+F+GTPYWMAPEVI A DE YD + D+WS GIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDLWSCGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRE 284
L +M+ M AL+ I +N P L+S +WS F +F++ CL K RP++E+LLKH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI-RD 291
Query: 285 RP-----ETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGV 339
+P L D I RT+ E D +Y ++G ++EEEEE
Sbjct: 292 QPNERQVRIQLKDHIDRTRKKRGEKDETEYE----------YSG----SEEEEEE----- 332
Query: 340 GRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHL 399
V + PS ++ +S+ + + E ++ L
Sbjct: 333 --------VPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQ---QL 381
Query: 400 KPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQ--- 456
+ +EE R+ R + + Q + + R RE R+ QE EQ
Sbjct: 382 REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRRERE-----------ARRQQEREQRRR 430
Query: 457 DSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIK 516
+ E + ++ +R R++ +++ E K + E ++ +R + LE ++ + ++L++
Sbjct: 431 EQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIR--RQLEEEQRHLEVLQQQLLQ 488
Query: 517 KHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQST 576
+ AM E + EE + + +Q Q ++E ++L S + +++ Q ++
Sbjct: 489 --EQAMLLECRWREMEEHRQAERLQRQLQQE-QAYLLSLQHDHRRPHPQHSQQ----PPP 541
Query: 577 PKKEKQEWLSKQKENIQHFQAEEEA 601
P++E+ + E H++ + A
Sbjct: 542 PQQERSKPSFHAPEPKAHYEPADRA 566
Score = 60.5 bits (145), Expect = 8e-09
Identities = 64/283 (22%), Positives = 133/283 (46%), Gaps = 29/283 (10%)
Query: 534 KKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQ 593
K + Q +Q + + F+ Q E ++R QLK+ ++ +K++ E K + +
Sbjct: 272 KNYMQRPSTEQLLK-HPFIRDQPNERQVRI-QLKDHIDRT----RKKRGE---KDETEYE 322
Query: 594 HFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLL 653
+ +EEE + + E E + G L +D +R + ++ + L LL
Sbjct: 323 YSGSEEE------EEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLL 376
Query: 654 RQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPK 713
++ + ++ E++ ++ + R++ Q E +LE +RRERE R RQQ +
Sbjct: 377 QEQQLREQEEYKRQLLAERQK----RIEQQKEQRRRLEEQQRREREAR-------RQQER 425
Query: 714 SLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAE 773
+ +E + K++ ++ + + + + R + + E + + ++L+EEQ R L +L +
Sbjct: 426 EQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQ-RHLEVLQQ 484
Query: 774 QYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQ 816
Q +L + ++E ++AE L+ QLQQE L + Q
Sbjct: 485 QLLQEQAMLLECRWREMEEHRQAE--RLQRQLQQEQAYLLSLQ 525
Score = 54.7 bits (130), Expect = 4e-07
Identities = 50/195 (25%), Positives = 101/195 (51%), Gaps = 31/195 (15%)
Query: 494 LRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAK--VMSNEEKKFQQHIQAQQKKELNSF 551
LRL + E + + A ++L+++ Q ++E K +++ +K+ +Q Q +Q++ L
Sbjct: 357 LRLQQ--ENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQ--QKEQRRRLE-- 410
Query: 552 LESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYL 611
E Q+RE + R++Q +E+ Q K+ +E ++KE + +AEEE + R+++Y+
Sbjct: 411 -EQQRREREARRQQEREQRRREQEE-KRRLEELERRRKEEEERRRAEEEKRRVEREQEYI 468
Query: 612 ELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLL----RQHESMQELEFRHL 667
+ +R + + L+Q L++E+ AMLL R+ E ++ E R
Sbjct: 469 RRQLEEEQRHLEV----LQQQLLQEQ------------AMLLECRWREMEEHRQAE-RLQ 511
Query: 668 NTIQKMRCELIRLQH 682
+Q+ + L+ LQH
Sbjct: 512 RQLQQEQAYLLSLQH 526
Score = 53.9 bits (128), Expect = 7e-07
Identities = 74/311 (23%), Positives = 129/311 (41%), Gaps = 33/311 (10%)
Query: 419 PQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQL 478
P++PP R KS +++ F+ I LV MQ + L+ + RQ + QL
Sbjct: 246 PRNPPP--RLKSKKWSKKFFSFIE-GCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQL 302
Query: 479 ---MTLENKLKAEMDEHRLRLDKDLETQRNNFAAEME----------KLIKKHQAAMEKE 525
+ K + E DE E + E E +++ +++E
Sbjct: 303 KDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQE 362
Query: 526 AKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWL 585
K S E + QQ +Q QQ +E + E + R EQ KE+ + ++E++
Sbjct: 363 NKERS-EALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARR 421
Query: 586 SKQKENIQHFQAEEEANLLRRQRQYLELECRRF----KRRMLLGRHNLEQDLVREELNKR 641
+++E + Q EE+ L +R+ E E RR KRR+ EQ+ +R +L +
Sbjct: 422 QQEREQRRREQ-EEKRRLEELERRRKEEEERRRAEEEKRRV-----EREQEYIRRQLEEE 475
Query: 642 QTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELR 701
Q ++ LL++ + E +R + ++ RLQ Q L + Y + + R
Sbjct: 476 QRHLEVLQQQLLQEQAMLLECRWREMEEHRQAE----RLQRQ--LQQEQAYLLSLQHDHR 529
Query: 702 RKHVMEVRQQP 712
R H +Q P
Sbjct: 530 RPHPQHSQQPP 540
Score = 42.4 bits (98), Expect = 0.002
Identities = 64/264 (24%), Positives = 116/264 (43%), Gaps = 43/264 (16%)
Query: 629 LEQDLVREELNKRQTQKDLEHAMLLRQ-HESMQELEFR-HLNTIQKMRCELIRLQHQTEL 686
+E LV+ + + T++ L+H + Q +E ++ + H++ +K R E + +TE
Sbjct: 266 IEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGE----KDETEY 321
Query: 687 TNQLEYNKRRERELRRKHVMEVRQQPKSLKSK--ELQIKKQFQDTCKIQTRQYKALRNHL 744
EY+ E E + V E +P S+ + E +++ F + + +ALR
Sbjct: 322 ----EYSGSEEEE---EEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQ 374
Query: 745 LETTPKSEHKAVLKRLKEEQTR-----KLAILAEQYDHSINEMLSTQALRLDEAQ----E 795
L L+E+Q R K +LAE+ E Q RL+E Q E
Sbjct: 375 L--------------LQEQQLREQEEYKRQLLAERQKRI--EQQKEQRRRLEEQQRRERE 418
Query: 796 AECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEE--- 852
A Q + Q ++E E + + + E + R E ++RV + + +++EEE
Sbjct: 419 ARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRH 478
Query: 853 MLALQNERTERIRSLLERQAREIE 876
+ LQ + + LLE + RE+E
Sbjct: 479 LEVLQQQLLQEQAMLLECRWREME 502
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 230 bits (587), Expect = 4e-60
Identities = 183/612 (29%), Positives = 300/612 (49%), Gaps = 85/612 (13%)
Query: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
M + + A SL D +++ L DP +F + +G+G++G VY R V+T ++ AIK M
Sbjct: 1 MANDSPAKSLVDIDLSSL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIE-YKGCYLR------EHTAWLVMEYC-LGSA 112
+ + E I E+ L++ H +I Y G +++ + WLVME+C GS
Sbjct: 58 VTEDEEEE----IKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSI 113
Query: 113 SDLLEVHK-KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFG 171
+DL++ K L+E IA I+ L+GLA+LH H +IHRDIK N+LLTE +VKL DFG
Sbjct: 114 TDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SASMASPA----NSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ N+F+GTPYWMAPEVI A DE YD + D+WS GIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDLWSCGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRE 284
L +M+ M AL+ I +N P L+S +WS F +F++ CL K RP++E+LLKH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI-RD 291
Query: 285 RP-----ETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGV 339
+P L D I RT+ E D +Y ++G ++EEEEE
Sbjct: 292 QPNERQVRIQLKDHIDRTRKKRGEKDETEYE----------YSG----SEEEEEE----- 332
Query: 340 GRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHL 399
V + PS ++ +S+ + + E ++ L
Sbjct: 333 --------VPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQ---QL 381
Query: 400 KPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSE 459
+ +EE R+ R + + Q + + R RE R+ QE EQ
Sbjct: 382 REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRRERE-----------ARRQQEREQRRR 430
Query: 460 LREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQ 519
+E+ + + R+ +++ E + +AE E + R++++ E R E L Q
Sbjct: 431 EQEEKRRLEELERRRKEE----EERRRAE--EEKRRVEREQEYIRRQLEEEQRHLEVLQQ 484
Query: 520 AAMEKEAKVMSNEEKKFQQHIQ----AQQKKELNSFLESQKREYKLRKEQLKEELNE--- 572
++++A ++ + + QH Q QQ++ SF + + + ++ +E +
Sbjct: 485 QLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRK 544
Query: 573 -NQSTPKKEKQE 583
N S+P+ + ++
Sbjct: 545 TNHSSPEAQSKQ 556
Score = 52.8 bits (125), Expect = 2e-06
Identities = 95/454 (20%), Positives = 180/454 (39%), Gaps = 62/454 (13%)
Query: 534 KKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQ 593
K + Q +Q + + F+ Q E ++R QLK+ ++ +K++ E K + +
Sbjct: 272 KNYMQRPSTEQLLK-HPFIRDQPNERQVRI-QLKDHIDRT----RKKRGE---KDETEYE 322
Query: 594 HFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLL 653
+ +EEE + + E E + G L +D +R + ++ + L LL
Sbjct: 323 YSGSEEE------EEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLL 376
Query: 654 RQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPK 713
++ + ++ E++ ++ + R++ Q E +LE +RRERE R RQQ +
Sbjct: 377 QEQQLREQEEYKRQLLAERQK----RIEQQKEQRRRLEEQQRREREAR-------RQQER 425
Query: 714 SLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAE 773
+ +E + K++ ++ + + + + R + + E + + ++L+EEQ R L +L +
Sbjct: 426 EQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQ-RHLEVLQQ 484
Query: 774 QYDHSINEMLSTQALRLDEAQEAECQVLKM--QLQQELELLNAYQSKIKMQAE-AQHDRE 830
Q +L QA+ L + + Q + QQE + + + K E A RE
Sbjct: 485 Q-------LLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRARE 537
Query: 831 LREL---------EQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSE 881
+ + E + +LE + + N +E + L+R A
Sbjct: 538 VEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAE-----PQV 592
Query: 882 SMRLGFSNMVLSNLSPEAFSHSYPGASGWSHNPTGGPGPH--WGH-----PMGGPPQAWG 934
+R + VLS + N T P W P G + G
Sbjct: 593 PVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSG 652
Query: 935 HPMQGGPQPWGHPSGPMQGVPRGSSMGVRNSPQA 968
G QP HP G G G VR+S ++
Sbjct: 653 -SSNSGSQPGSHP-GSQSG--SGERFRVRSSSKS 682
Score = 52.4 bits (124), Expect = 2e-06
Identities = 78/300 (26%), Positives = 134/300 (44%), Gaps = 42/300 (14%)
Query: 419 PQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQL 478
P++PP R KS +++ F+ I LV MQ EQ+ + +R Q ++
Sbjct: 246 PRNPPP--RLKSKKWSKKFFSFIE-GCLVKNYMQRPST-----EQLLKHPFIRDQPNERQ 297
Query: 479 MTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQ 538
+ ++ LK +D R + + ET+ +E E+ Q + E +
Sbjct: 298 VRIQ--LKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRD 355
Query: 539 HIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAE 598
++ QQ+ + S E+ +R+ L+++QL+E+ E + E+Q+ + +QKE Q + E
Sbjct: 356 FLRLQQENKERS--EALRRQQLLQEQQLREQ-EEYKRQLLAERQKRIEQQKE--QRRRLE 410
Query: 599 EEANLLRRQRQYLELECRR----FKRRM--LLGRHNLEQDLVREELNKRQTQKDLEHAML 652
E+ R R+ E E RR KRR+ L R E++ R E KR+ +++ E+ +
Sbjct: 411 EQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEY--I 468
Query: 653 LRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQP 712
RQ E Q RHL +Q+ LQ Q L + + RR H +Q P
Sbjct: 469 RRQLEEEQ----RHLEVLQQQ-----LLQEQAMLLH----------DHRRPHPQHSQQPP 509
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 229 bits (583), Expect = 1e-59
Identities = 179/576 (31%), Positives = 284/576 (49%), Gaps = 81/576 (14%)
Query: 1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS 60
M + + A SL D +++ L DP +F + +G+G++G VY R V+T ++ AIK M
Sbjct: 1 MANDSPAKSLVDIDLSSL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD 57
Query: 61 YSGKQSTEKWQDIIKEVKFLQRIKHPNSIE-YKGCYLR------EHTAWLVMEYC-LGSA 112
+ + E I E+ L++ H +I Y G +++ + WLVME+C GS
Sbjct: 58 VTEDEEEE----IKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSI 113
Query: 113 SDLLEVHK-KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFG 171
+DL++ K L+E IA I+ L+GLA+LH H +IHRDIK N+LLTE +VKL DFG
Sbjct: 114 TDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFG 173
Query: 172 SASMASPA----NSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPP 224
++ N+F+GTPYWMAPEVI A DE YD + D+WS GIT IE+AE PP
Sbjct: 174 VSAQLDRTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDLWSCGITAIEMAEGAPP 232
Query: 225 LFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRE 284
L +M+ M AL+ I +N P L+S +WS F +F++ CL K RP++E+LLKH F+ R+
Sbjct: 233 LCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI-RD 291
Query: 285 RP-----ETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGV 339
+P L D I RT+ E D +Y ++G ++EEEEE
Sbjct: 292 QPNERQVRIQLKDHIDRTRKKRGEKDETEYE----------YSG----SEEEEEE----- 332
Query: 340 GRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHL 399
V + PS ++ +S+ + + E ++ L
Sbjct: 333 --------VPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQ---QL 381
Query: 400 KPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSE 459
+ +EE R+ R + + Q + + R RE R+ QE EQ
Sbjct: 382 REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRRERE-----------ARRQQEREQRRR 430
Query: 460 LREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQ 519
+E+ + + R+ +++ E + +AE E + R++++ E R E L Q
Sbjct: 431 EQEEKRRLEELERRRKEE----EERRRAE--EEKRRVEREQEYIRRQLEEEQRHLEVLQQ 484
Query: 520 AAMEKEAKVMSNEEKKFQQHIQ----AQQKKELNSF 551
++++A ++ + + QH Q QQ++ SF
Sbjct: 485 QLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSF 520
Score = 53.1 bits (126), Expect = 1e-06
Identities = 81/390 (20%), Positives = 162/390 (41%), Gaps = 46/390 (11%)
Query: 534 KKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQ 593
K + Q +Q + + F+ Q E ++R QLK+ ++ +K++ E K + +
Sbjct: 272 KNYMQRPSTEQLLK-HPFIRDQPNERQVRI-QLKDHIDRT----RKKRGE---KDETEYE 322
Query: 594 HFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLL 653
+ +EEE + + E E + G L +D +R + ++ + L LL
Sbjct: 323 YSGSEEE------EEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLL 376
Query: 654 RQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPK 713
++ + ++ E++ ++ + R++ Q E +LE +RRERE R RQQ +
Sbjct: 377 QEQQLREQEEYKRQLLAERQK----RIEQQKEQRRRLEEQQRREREAR-------RQQER 425
Query: 714 SLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAE 773
+ +E + K++ ++ + + + + R + + E + + ++L+EEQ R L +L +
Sbjct: 426 EQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQ-RHLEVLQQ 484
Query: 774 QYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRE 833
Q +L QA+ L + + Q + + E + +A + RE
Sbjct: 485 Q-------LLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRARE 537
Query: 834 LEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLS 893
+ R + R +L ++ LQ + QA + + S RL + +
Sbjct: 538 VPVRTTSRSPVLSRRDS----PLQGSGQQ------NSQAGQRNSTSSIEPRLLWER--VE 585
Query: 894 NLSPEAFSHSYPGASGWSHNPTGGPGPHWG 923
L P S S G+S P PG G
Sbjct: 586 KLVPRPGSGSSSGSSNSGSQPGSHPGSQSG 615
Score = 52.4 bits (124), Expect = 2e-06
Identities = 78/300 (26%), Positives = 134/300 (44%), Gaps = 42/300 (14%)
Query: 419 PQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQL 478
P++PP R KS +++ F+ I LV MQ EQ+ + +R Q ++
Sbjct: 246 PRNPPP--RLKSKKWSKKFFSFIE-GCLVKNYMQRPST-----EQLLKHPFIRDQPNERQ 297
Query: 479 MTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQ 538
+ ++ LK +D R + + ET+ +E E+ Q + E +
Sbjct: 298 VRIQ--LKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRD 355
Query: 539 HIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAE 598
++ QQ+ + S E+ +R+ L+++QL+E+ E + E+Q+ + +QKE Q + E
Sbjct: 356 FLRLQQENKERS--EALRRQQLLQEQQLREQ-EEYKRQLLAERQKRIEQQKE--QRRRLE 410
Query: 599 EEANLLRRQRQYLELECRR----FKRRM--LLGRHNLEQDLVREELNKRQTQKDLEHAML 652
E+ R R+ E E RR KRR+ L R E++ R E KR+ +++ E+ +
Sbjct: 411 EQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEY--I 468
Query: 653 LRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQP 712
RQ E Q RHL +Q+ LQ Q L + + RR H +Q P
Sbjct: 469 RRQLEEEQ----RHLEVLQQQ-----LLQEQAMLLH----------DHRRPHPQHSQQPP 509
Score = 45.1 bits (105), Expect = 3e-04
Identities = 45/189 (23%), Positives = 85/189 (44%), Gaps = 30/189 (15%)
Query: 402 EEENYREEGDPRTRASDP-QSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSEL 460
EEE +EG+P + + P +S + + N+E +R L+ Q+ +L
Sbjct: 330 EEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLL--------QEQQL 381
Query: 461 REQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQA 520
REQ ++++QL+ K + E R RL+ E QR A ++
Sbjct: 382 REQ--------EEYKRQLLAERQKRIEQQKEQRRRLE---EQQRREREARRQQ------- 423
Query: 521 AMEKEAKVMSNEEKKFQQHIQAQQK-KELNSFLESQKREYKLRKEQLKEELNENQSTPKK 579
E+E + EEK+ + ++ ++K +E E +KR + +E ++ +L E Q +
Sbjct: 424 --EREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEV 481
Query: 580 EKQEWLSKQ 588
+Q+ L +Q
Sbjct: 482 LQQQLLQEQ 490
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 227 bits (579), Expect = 4e-59
Identities = 135/282 (47%), Positives = 177/282 (62%), Gaps = 14/282 (4%)
Query: 23 DPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQR 82
DPE+LFT L IG GSFG VY D T EVVAIK + +++ ++ +DI +E+ L +
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDL--EEAEDEIEDIQQEITVLSQ 72
Query: 83 IKHPNSIEYKGCYLREHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAITHGALQGLAY 141
P Y G YL+ W++MEY G SA DLL+ PL+E IA I L+GL Y
Sbjct: 73 CDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK--PGPLEETYIATILREILKGLDY 130
Query: 142 LHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVILAM 197
LHS IHRDIKA N+LL+E G VKLADFG A + N+FVGTP+WMAPEVI
Sbjct: 131 LHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI--- 187
Query: 198 DEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNF 257
+ YD K D+WSLGIT IELA+ +PP +++ M L+ I +N PTL+ + S F+ F
Sbjct: 188 KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLE-GQHSKPFKEF 246
Query: 258 VDSCLQKIPQDRPTSEELLKHIFVLRERPET-VLIDLIQRTK 298
V++CL K P+ RPT++ELLKH F+ R +T L +LI R K
Sbjct: 247 VEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYK 288
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 225 bits (574), Expect = 1e-58
Identities = 174/560 (31%), Positives = 289/560 (51%), Gaps = 88/560 (15%)
Query: 7 AGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQS 66
A SL D +++ L DP +F + +G+G++G VY R V+T ++ AIK M + +
Sbjct: 7 ARSLDDIDLSAL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 TEKWQDIIKEVKFLQRIKHPNSIE-YKGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I +E+ L++ H +I Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN 119
Query: 119 HK-KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMAS 177
K L+E IA I L+GLA+LH+H +IHRDIK N+LLTE +VKL DFG ++
Sbjct: 120 TKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 178 PA----NSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
N+F+GTPYWMAPEVI A DE YD + D+WSLGIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVL 290
M AL+ I +N P L+S +WS F +F+D+CL K RP +E+LLK F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI-RDQPTERQ 297
Query: 291 IDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGS 350
+ + + KD +D + ++ +K + ++G EEE+ HG
Sbjct: 298 VRI--QLKD---HIDRSRKKRGEKEETEYEYSG------SEEEDDSHG------------ 334
Query: 351 NQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEG 410
+ SS+ ++P S + E ++ ++ SNS + + ++ +++
Sbjct: 335 ----------EEGEPSSIMNVPGESTLRREFLRLQQEN--KSNSEALK-QQQQLQQQQQR 381
Query: 411 DPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRM 470
DP +H H R R R ++ E+ + EQ +
Sbjct: 382 DPEAHI----------KHLLHQRQR-------------RIEEQKEERRRVEEQQRREREQ 418
Query: 471 RR-QHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKE-AKV 528
R+ Q ++Q LE+ +E R + +++ E +R E ++ ++ Q +++E A +
Sbjct: 419 RKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQL--EEQRQSERLQRQLQQEHAYL 476
Query: 529 MSNEEKKFQQHIQAQQKKEL 548
S ++++ QQ +Q QQ+++L
Sbjct: 477 KSLQQQQQQQQLQKQQQQQL 496
Score = 48.1 bits (113), Expect = 4e-05
Identities = 38/152 (25%), Positives = 77/152 (50%), Gaps = 10/152 (6%)
Query: 512 EKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELN 571
E +++ +++E K ++E K QQ +Q QQ+++ + ++ + + R E+ KEE
Sbjct: 348 ESTLRREFLRLQQENK-SNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERR 406
Query: 572 ENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQ 631
+ ++E+++ ++KE + E+ LRR E E R+ +R R LE+
Sbjct: 407 RVEEQQRREREQRKLQEKEQQRRL---EDMQALRR-----EEERRQAEREQEYKRKQLEE 458
Query: 632 DLVREELNKRQTQKDLEHAMLLRQHESMQELE 663
E L +RQ Q++ + L+Q + Q+L+
Sbjct: 459 QRQSERL-QRQLQQEHAYLKSLQQQQQQQQLQ 489
Score = 43.1 bits (100), Expect = 0.001
Identities = 39/175 (22%), Positives = 97/175 (55%), Gaps = 12/175 (6%)
Query: 402 EEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQ-DSEL 460
E++++ EEG+P +S P + + + R ++ + A +Q+Q+ +Q D E
Sbjct: 329 EDDSHGEEGEP---SSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEA 385
Query: 461 REQMSGYKRMRR--QHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKH 518
+ ++R RR + +++ +E + + E ++ +L+ +K+ + + + A + + ++
Sbjct: 386 HIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQ-EKEQQRRLEDMQA-LRREEERR 443
Query: 519 QAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLES---QKREYKLRKEQLKEEL 570
QA E+E K EE++ + +Q Q ++E +++L+S Q+++ +L+K+Q ++ L
Sbjct: 444 QAEREQEYKRKQLEEQRQSERLQRQLQQE-HAYLKSLQQQQQQQQLQKQQQQQLL 497
Score = 42.7 bits (99), Expect = 0.002
Identities = 62/262 (23%), Positives = 115/262 (43%), Gaps = 35/262 (13%)
Query: 702 RKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPK--SEHKAVLKR 759
R+ + ++Q+ KS S+ L+ ++Q Q Q R +A HLL + E K +R
Sbjct: 352 RREFLRLQQENKS-NSEALKQQQQLQQQ---QQRDPEAHIKHLLHQRQRRIEEQKEERRR 407
Query: 760 LKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKI 819
++E+Q R E+ + E Q RL++ Q + + Q ++E E Y+ K
Sbjct: 408 VEEQQRR------EREQRKLQE--KEQQRRLEDMQALRREEERRQAEREQE----YKRK- 454
Query: 820 KMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERI----RSLLERQAREI 875
+++ + Q +R R+L+Q + ++L +Q+ +++ LQ ++ +++ R L R +
Sbjct: 455 QLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQ---LQKQQQQQLLPGDRKPLYHYGRGM 511
Query: 876 EAFDSESMRLGFSNMVLSNLSPEA-FSHSYPGASGWSHN-PTGGPGPHWGHPMGGPPQAW 933
D + N + + S PG++G P PGP P+ P
Sbjct: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGP--PGPLSQTP--- 566
Query: 934 GHPMQGGPQPWGHPSGPMQGVP 955
PMQ +P P +Q P
Sbjct: 567 --PMQRPVEPQEGPHKSLQDQP 586
Score = 41.6 bits (96), Expect = 0.004
Identities = 34/142 (23%), Positives = 71/142 (50%), Gaps = 21/142 (14%)
Query: 516 KKHQAAMEKEAKVMSNEEKKFQQHIQ----------AQQKKELNSFLESQKREYKLRKEQ 565
K + A++++ ++ +++ + HI+ +QK+E E Q+RE + RK Q
Sbjct: 363 KSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQ 422
Query: 566 LKEELN--ENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRML 623
KE+ E+ ++E++ +++++ + Q EE+ R QRQ L+ E K
Sbjct: 423 EKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQ-LQQEHAYLK---- 477
Query: 624 LGRHNLEQDLVREELNKRQTQK 645
+L+Q +++L K+Q Q+
Sbjct: 478 ----SLQQQQQQQQLQKQQQQQ 495
Score = 40.8 bits (94), Expect = 0.006
Identities = 37/181 (20%), Positives = 83/181 (45%), Gaps = 34/181 (18%)
Query: 657 ESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLK 716
ES EF L K E ++ Q Q L+ ++R+ E KH++ RQ+
Sbjct: 348 ESTLRREFLRLQQENKSNSEALKQQQQ------LQQQQQRDPEAHIKHLLHQRQR----- 396
Query: 717 SKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYD 776
+I++Q ++ +++ +Q + L+ + ++ L+ E+ R+ A ++Y
Sbjct: 397 ----RIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYK 452
Query: 777 HSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQ 836
+L+E +++E +LQ++L+ +AY ++ Q Q ++L++ +Q
Sbjct: 453 RK----------QLEEQRQSE------RLQRQLQQEHAYLKSLQQQ---QQQQQLQKQQQ 493
Query: 837 R 837
+
Sbjct: 494 Q 494
Score = 40.4 bits (93), Expect = 0.008
Identities = 42/214 (19%), Positives = 92/214 (42%), Gaps = 31/214 (14%)
Query: 535 KFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKE---------KQEWL 585
+ + HI +KK E ++ EY+ + +++ + + P ++E+L
Sbjct: 301 QLKDHIDRSRKKRG----EKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFL 356
Query: 586 SKQKENIQHFQAEEEANLLRRQRQY---LELECRRFKRRMLLGRHNLEQDLVREELNKRQ 642
Q+EN + +A ++ L++Q+Q ++ +R+ + E+ V E+ + +
Sbjct: 357 RLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRRER 416
Query: 643 TQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRR 702
Q+ L+ R+ E MQ L R + + + + EY +++ E R+
Sbjct: 417 EQRKLQEKEQQRRLEDMQALR---------------REEERRQAEREQEYKRKQLEEQRQ 461
Query: 703 KHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQ 736
++ + Q + K LQ ++Q Q K Q +Q
Sbjct: 462 SERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495
Score = 39.3 bits (90), Expect = 0.019
Identities = 35/154 (22%), Positives = 78/154 (50%), Gaps = 12/154 (7%)
Query: 475 QKQLMTL--ENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAME--KEAKVMS 530
+++ + L ENK +E + + +L + Q+ + A ++ L+ + Q +E KE +
Sbjct: 352 RREFLRLQQENKSNSEALKQQQQLQ---QQQQRDPEAHIKHLLHQRQRRIEEQKEERRRV 408
Query: 531 NEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKE 590
E+++ ++ + Q+KE LE + LR+E+ + + Q +K+ +E +Q E
Sbjct: 409 EEQQRREREQRKLQEKEQQRRLEDMQ---ALRREEERRQAEREQEYKRKQLEE--QRQSE 463
Query: 591 NIQHFQAEEEANLLRRQRQYLELECRRFKRRMLL 624
+Q +E A L Q+Q + + ++ +++ LL
Sbjct: 464 RLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
Score = 38.9 bits (89), Expect = 0.024
Identities = 51/203 (25%), Positives = 83/203 (40%), Gaps = 33/203 (16%)
Query: 709 RQQPKSLKSKELQIKK-QFQDTCKIQTR----------QYKALRNHLLETTPKSEHKAVL 757
R P LKSK+ K F DTC I+T ++ +R+ E + + K +
Sbjct: 247 RNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHI 306
Query: 758 -----KRLKEEQTRKLAILAEQYDHSINE--------------MLSTQALRLDEAQEAEC 798
KR ++E+T +E+ D S E L + LRL + ++
Sbjct: 307 DRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNS 366
Query: 799 QVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQN 858
+ LK Q Q + + ++ IK H R+ R EQ+ RR +Q+ E E LQ
Sbjct: 367 EALKQQQQLQQQQQRDPEAHIK---HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQE 423
Query: 859 ERTERIRSLLERQAREIEAFDSE 881
+ +R ++ RE E +E
Sbjct: 424 KEQQRRLEDMQALRREEERRQAE 446
Score = 37.7 bits (86), Expect = 0.054
Identities = 55/263 (20%), Positives = 114/263 (43%), Gaps = 58/263 (22%)
Query: 551 FLESQKREYKLRKEQLKEELNENQSTPKKEKQ---EWLSKQKENIQHFQAEEEANLLRRQ 607
F+ Q E ++R QLK+ ++ ++ ++++ E+ ++E+ H + E ++++
Sbjct: 288 FIRDQPTERQVRI-QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMN-- 344
Query: 608 RQYLELECRRFKRRMLLGRHNLEQDLVR-EELNKRQTQKDLEHAMLLRQHESMQELEFRH 666
+ G L ++ +R ++ NK ++ + L +Q + E +H
Sbjct: 345 ---------------VPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKH 389
Query: 667 LNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQF 726
L Q+ R R++ Q E ++E +RRERE R+ L+ KE Q ++
Sbjct: 390 L-LHQRQR----RIEEQKEERRRVEEQQRREREQRK------------LQEKEQQ--RRL 430
Query: 727 QDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQ 786
+D +ALR + E + K+L+E++ + Q +H+ + L
Sbjct: 431 EDM--------QALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ-- 480
Query: 787 ALRLDEAQEAECQVLKMQLQQEL 809
Q+ + Q L+ Q QQ+L
Sbjct: 481 -------QQQQQQQLQKQQQQQL 496
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 225 bits (574), Expect = 1e-58
Identities = 174/560 (31%), Positives = 289/560 (51%), Gaps = 88/560 (15%)
Query: 7 AGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQS 66
A SL D +++ L DP +F + +G+G++G VY R V+T ++ AIK M + +
Sbjct: 7 ARSLDDIDLSAL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 TEKWQDIIKEVKFLQRIKHPNSIE-YKGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I +E+ L++ H +I Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN 119
Query: 119 HK-KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMAS 177
K L+E IA I L+GLA+LH+H +IHRDIK N+LLTE +VKL DFG ++
Sbjct: 120 TKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 178 PA----NSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
N+F+GTPYWMAPEVI A DE YD + D+WSLGIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVL 290
M AL+ I +N P L+S +WS F +F+D+CL K RP +E+LLK F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI-RDQPTERQ 297
Query: 291 IDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGS 350
+ + + KD +D + ++ +K + ++G EEE+ HG
Sbjct: 298 VRI--QLKD---HIDRSRKKRGEKEETEYEYSG------SEEEDDSHG------------ 334
Query: 351 NQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEG 410
+ SS+ ++P S + E ++ ++ SNS + + ++ +++
Sbjct: 335 ----------EEGEPSSIMNVPGESTLRREFLRLQQEN--KSNSEALK-QQQQLQQQQQR 381
Query: 411 DPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRM 470
DP +H H R R R ++ E+ + EQ +
Sbjct: 382 DPEAHI----------KHLLHQRQR-------------RIEEQKEERRRVEEQQRREREQ 418
Query: 471 RR-QHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKE-AKV 528
R+ Q ++Q LE+ +E R + +++ E +R E ++ ++ Q +++E A +
Sbjct: 419 RKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQL--EEQRQSERLQRQLQQEHAYL 476
Query: 529 MSNEEKKFQQHIQAQQKKEL 548
S ++++ QQ +Q QQ+++L
Sbjct: 477 KSLQQQQQQQQLQKQQQQQL 496
Score = 48.1 bits (113), Expect = 4e-05
Identities = 38/152 (25%), Positives = 77/152 (50%), Gaps = 10/152 (6%)
Query: 512 EKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELN 571
E +++ +++E K ++E K QQ +Q QQ+++ + ++ + + R E+ KEE
Sbjct: 348 ESTLRREFLRLQQENK-SNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERR 406
Query: 572 ENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQ 631
+ ++E+++ ++KE + E+ LRR E E R+ +R R LE+
Sbjct: 407 RVEEQQRREREQRKLQEKEQQRRL---EDMQALRR-----EEERRQAEREQEYKRKQLEE 458
Query: 632 DLVREELNKRQTQKDLEHAMLLRQHESMQELE 663
E L +RQ Q++ + L+Q + Q+L+
Sbjct: 459 QRQSERL-QRQLQQEHAYLKSLQQQQQQQQLQ 489
Score = 43.1 bits (100), Expect = 0.001
Identities = 39/175 (22%), Positives = 97/175 (55%), Gaps = 12/175 (6%)
Query: 402 EEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQ-DSEL 460
E++++ EEG+P +S P + + + R ++ + A +Q+Q+ +Q D E
Sbjct: 329 EDDSHGEEGEP---SSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEA 385
Query: 461 REQMSGYKRMRR--QHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKH 518
+ ++R RR + +++ +E + + E ++ +L+ +K+ + + + A + + ++
Sbjct: 386 HIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQ-EKEQQRRLEDMQA-LRREEERR 443
Query: 519 QAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLES---QKREYKLRKEQLKEEL 570
QA E+E K EE++ + +Q Q ++E +++L+S Q+++ +L+K+Q ++ L
Sbjct: 444 QAEREQEYKRKQLEEQRQSERLQRQLQQE-HAYLKSLQQQQQQQQLQKQQQQQLL 497
Score = 41.6 bits (96), Expect = 0.004
Identities = 34/142 (23%), Positives = 71/142 (50%), Gaps = 21/142 (14%)
Query: 516 KKHQAAMEKEAKVMSNEEKKFQQHIQ----------AQQKKELNSFLESQKREYKLRKEQ 565
K + A++++ ++ +++ + HI+ +QK+E E Q+RE + RK Q
Sbjct: 363 KSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQ 422
Query: 566 LKEELN--ENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRML 623
KE+ E+ ++E++ +++++ + Q EE+ R QRQ L+ E K
Sbjct: 423 EKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQ-LQQEHAYLK---- 477
Query: 624 LGRHNLEQDLVREELNKRQTQK 645
+L+Q +++L K+Q Q+
Sbjct: 478 ----SLQQQQQQQQLQKQQQQQ 495
Score = 40.8 bits (94), Expect = 0.006
Identities = 37/181 (20%), Positives = 83/181 (45%), Gaps = 34/181 (18%)
Query: 657 ESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLK 716
ES EF L K E ++ Q Q L+ ++R+ E KH++ RQ+
Sbjct: 348 ESTLRREFLRLQQENKSNSEALKQQQQ------LQQQQQRDPEAHIKHLLHQRQR----- 396
Query: 717 SKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYD 776
+I++Q ++ +++ +Q + L+ + ++ L+ E+ R+ A ++Y
Sbjct: 397 ----RIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYK 452
Query: 777 HSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQ 836
+L+E +++E +LQ++L+ +AY ++ Q Q ++L++ +Q
Sbjct: 453 RK----------QLEEQRQSE------RLQRQLQQEHAYLKSLQQQ---QQQQQLQKQQQ 493
Query: 837 R 837
+
Sbjct: 494 Q 494
Score = 40.8 bits (94), Expect = 0.006
Identities = 57/246 (23%), Positives = 108/246 (43%), Gaps = 28/246 (11%)
Query: 702 RKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPK--SEHKAVLKR 759
R+ + ++Q+ KS S+ L+ ++Q Q Q R +A HLL + E K +R
Sbjct: 352 RREFLRLQQENKS-NSEALKQQQQLQQQ---QQRDPEAHIKHLLHQRQRRIEEQKEERRR 407
Query: 760 LKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKI 819
++E+Q R E+ + E Q RL++ Q + + Q ++E E Y+ K
Sbjct: 408 VEEQQRR------EREQRKLQE--KEQQRRLEDMQALRREEERRQAEREQE----YKRK- 454
Query: 820 KMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERI----RSLLERQAREI 875
+++ + Q +R R+L+Q + ++L +Q+ +++ LQ ++ +++ R L R +
Sbjct: 455 QLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQ---LQKQQQQQLLPGDRKPLYHYGRGM 511
Query: 876 EAFDSESMRLGFSNMVLSNLSPEA-FSHSYPGASGWSHN-PTGGPGPHWGHPMGGPPQAW 933
D + N + + S PG++G P PGP P Q
Sbjct: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP 571
Query: 934 GHPMQG 939
P +G
Sbjct: 572 VEPQEG 577
Score = 40.4 bits (93), Expect = 0.008
Identities = 42/214 (19%), Positives = 92/214 (42%), Gaps = 31/214 (14%)
Query: 535 KFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKE---------KQEWL 585
+ + HI +KK E ++ EY+ + +++ + + P ++E+L
Sbjct: 301 QLKDHIDRSRKKRG----EKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFL 356
Query: 586 SKQKENIQHFQAEEEANLLRRQRQY---LELECRRFKRRMLLGRHNLEQDLVREELNKRQ 642
Q+EN + +A ++ L++Q+Q ++ +R+ + E+ V E+ + +
Sbjct: 357 RLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRRER 416
Query: 643 TQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRR 702
Q+ L+ R+ E MQ L R + + + + EY +++ E R+
Sbjct: 417 EQRKLQEKEQQRRLEDMQALR---------------REEERRQAEREQEYKRKQLEEQRQ 461
Query: 703 KHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQ 736
++ + Q + K LQ ++Q Q K Q +Q
Sbjct: 462 SERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495
Score = 39.3 bits (90), Expect = 0.019
Identities = 35/154 (22%), Positives = 78/154 (50%), Gaps = 12/154 (7%)
Query: 475 QKQLMTL--ENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAME--KEAKVMS 530
+++ + L ENK +E + + +L + Q+ + A ++ L+ + Q +E KE +
Sbjct: 352 RREFLRLQQENKSNSEALKQQQQLQ---QQQQRDPEAHIKHLLHQRQRRIEEQKEERRRV 408
Query: 531 NEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKE 590
E+++ ++ + Q+KE LE + LR+E+ + + Q +K+ +E +Q E
Sbjct: 409 EEQQRREREQRKLQEKEQQRRLEDMQ---ALRREEERRQAEREQEYKRKQLEE--QRQSE 463
Query: 591 NIQHFQAEEEANLLRRQRQYLELECRRFKRRMLL 624
+Q +E A L Q+Q + + ++ +++ LL
Sbjct: 464 RLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
Score = 38.9 bits (89), Expect = 0.024
Identities = 51/203 (25%), Positives = 83/203 (40%), Gaps = 33/203 (16%)
Query: 709 RQQPKSLKSKELQIKK-QFQDTCKIQTR----------QYKALRNHLLETTPKSEHKAVL 757
R P LKSK+ K F DTC I+T ++ +R+ E + + K +
Sbjct: 247 RNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHI 306
Query: 758 -----KRLKEEQTRKLAILAEQYDHSINE--------------MLSTQALRLDEAQEAEC 798
KR ++E+T +E+ D S E L + LRL + ++
Sbjct: 307 DRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNS 366
Query: 799 QVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQN 858
+ LK Q Q + + ++ IK H R+ R EQ+ RR +Q+ E E LQ
Sbjct: 367 EALKQQQQLQQQQQRDPEAHIK---HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQE 423
Query: 859 ERTERIRSLLERQAREIEAFDSE 881
+ +R ++ RE E +E
Sbjct: 424 KEQQRRLEDMQALRREEERRQAE 446
Score = 37.7 bits (86), Expect = 0.054
Identities = 55/263 (20%), Positives = 114/263 (43%), Gaps = 58/263 (22%)
Query: 551 FLESQKREYKLRKEQLKEELNENQSTPKKEKQ---EWLSKQKENIQHFQAEEEANLLRRQ 607
F+ Q E ++R QLK+ ++ ++ ++++ E+ ++E+ H + E ++++
Sbjct: 288 FIRDQPTERQVRI-QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMN-- 344
Query: 608 RQYLELECRRFKRRMLLGRHNLEQDLVR-EELNKRQTQKDLEHAMLLRQHESMQELEFRH 666
+ G L ++ +R ++ NK ++ + L +Q + E +H
Sbjct: 345 ---------------VPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKH 389
Query: 667 LNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQF 726
L Q+ R R++ Q E ++E +RRERE R+ L+ KE Q ++
Sbjct: 390 L-LHQRQR----RIEEQKEERRRVEEQQRREREQRK------------LQEKEQQ--RRL 430
Query: 727 QDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQ 786
+D +ALR + E + K+L+E++ + Q +H+ + L
Sbjct: 431 EDM--------QALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ-- 480
Query: 787 ALRLDEAQEAECQVLKMQLQQEL 809
Q+ + Q L+ Q QQ+L
Sbjct: 481 -------QQQQQQQLQKQQQQQL 496
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 225 bits (574), Expect = 1e-58
Identities = 174/560 (31%), Positives = 289/560 (51%), Gaps = 88/560 (15%)
Query: 7 AGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQS 66
A SL D +++ L DP +F + +G+G++G VY R V+T ++ AIK M + +
Sbjct: 7 ARSLDDIDLSAL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 TEKWQDIIKEVKFLQRIKHPNSIE-YKGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I +E+ L++ H +I Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN 119
Query: 119 HK-KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMAS 177
K L+E IA I L+GLA+LH+H +IHRDIK N+LLTE +VKL DFG ++
Sbjct: 120 TKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 178 PA----NSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
N+F+GTPYWMAPEVI A DE YD + D+WSLGIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVL 290
M AL+ I +N P L+S +WS F +F+D+CL K RP +E+LLK F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI-RDQPTERQ 297
Query: 291 IDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGS 350
+ + + KD +D + ++ +K + ++G EEE+ HG
Sbjct: 298 VRI--QLKD---HIDRSRKKRGEKEETEYEYSG------SEEEDDSHG------------ 334
Query: 351 NQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEG 410
+ SS+ ++P S + E ++ ++ SNS + + ++ +++
Sbjct: 335 ----------EEGEPSSIMNVPGESTLRREFLRLQQEN--KSNSEALK-QQQQLQQQQQR 381
Query: 411 DPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRM 470
DP +H H R R R ++ E+ + EQ +
Sbjct: 382 DPEAHI----------KHLLHQRQR-------------RIEEQKEERRRVEEQQRREREQ 418
Query: 471 RR-QHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKE-AKV 528
R+ Q ++Q LE+ +E R + +++ E +R E ++ ++ Q +++E A +
Sbjct: 419 RKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQL--EEQRQSERLQRQLQQEHAYL 476
Query: 529 MSNEEKKFQQHIQAQQKKEL 548
S ++++ QQ +Q QQ+++L
Sbjct: 477 KSLQQQQQQQQLQKQQQQQL 496
Score = 48.1 bits (113), Expect = 4e-05
Identities = 38/152 (25%), Positives = 77/152 (50%), Gaps = 10/152 (6%)
Query: 512 EKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELN 571
E +++ +++E K ++E K QQ +Q QQ+++ + ++ + + R E+ KEE
Sbjct: 348 ESTLRREFLRLQQENK-SNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERR 406
Query: 572 ENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQ 631
+ ++E+++ ++KE + E+ LRR E E R+ +R R LE+
Sbjct: 407 RVEEQQRREREQRKLQEKEQQRRL---EDMQALRR-----EEERRQAEREQEYKRKQLEE 458
Query: 632 DLVREELNKRQTQKDLEHAMLLRQHESMQELE 663
E L +RQ Q++ + L+Q + Q+L+
Sbjct: 459 QRQSERL-QRQLQQEHAYLKSLQQQQQQQQLQ 489
Score = 43.1 bits (100), Expect = 0.001
Identities = 39/175 (22%), Positives = 97/175 (55%), Gaps = 12/175 (6%)
Query: 402 EEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQ-DSEL 460
E++++ EEG+P +S P + + + R ++ + A +Q+Q+ +Q D E
Sbjct: 329 EDDSHGEEGEP---SSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEA 385
Query: 461 REQMSGYKRMRR--QHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKH 518
+ ++R RR + +++ +E + + E ++ +L+ +K+ + + + A + + ++
Sbjct: 386 HIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQ-EKEQQRRLEDMQA-LRREEERR 443
Query: 519 QAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLES---QKREYKLRKEQLKEEL 570
QA E+E K EE++ + +Q Q ++E +++L+S Q+++ +L+K+Q ++ L
Sbjct: 444 QAEREQEYKRKQLEEQRQSERLQRQLQQE-HAYLKSLQQQQQQQQLQKQQQQQLL 497
Score = 41.6 bits (96), Expect = 0.004
Identities = 34/142 (23%), Positives = 71/142 (50%), Gaps = 21/142 (14%)
Query: 516 KKHQAAMEKEAKVMSNEEKKFQQHIQ----------AQQKKELNSFLESQKREYKLRKEQ 565
K + A++++ ++ +++ + HI+ +QK+E E Q+RE + RK Q
Sbjct: 363 KSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQ 422
Query: 566 LKEELN--ENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRML 623
KE+ E+ ++E++ +++++ + Q EE+ R QRQ L+ E K
Sbjct: 423 EKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQ-LQQEHAYLK---- 477
Query: 624 LGRHNLEQDLVREELNKRQTQK 645
+L+Q +++L K+Q Q+
Sbjct: 478 ----SLQQQQQQQQLQKQQQQQ 495
Score = 40.8 bits (94), Expect = 0.006
Identities = 37/181 (20%), Positives = 83/181 (45%), Gaps = 34/181 (18%)
Query: 657 ESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLK 716
ES EF L K E ++ Q Q L+ ++R+ E KH++ RQ+
Sbjct: 348 ESTLRREFLRLQQENKSNSEALKQQQQ------LQQQQQRDPEAHIKHLLHQRQR----- 396
Query: 717 SKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYD 776
+I++Q ++ +++ +Q + L+ + ++ L+ E+ R+ A ++Y
Sbjct: 397 ----RIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYK 452
Query: 777 HSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQ 836
+L+E +++E +LQ++L+ +AY ++ Q Q ++L++ +Q
Sbjct: 453 RK----------QLEEQRQSE------RLQRQLQQEHAYLKSLQQQ---QQQQQLQKQQQ 493
Query: 837 R 837
+
Sbjct: 494 Q 494
Score = 40.8 bits (94), Expect = 0.006
Identities = 57/246 (23%), Positives = 108/246 (43%), Gaps = 28/246 (11%)
Query: 702 RKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPK--SEHKAVLKR 759
R+ + ++Q+ KS S+ L+ ++Q Q Q R +A HLL + E K +R
Sbjct: 352 RREFLRLQQENKS-NSEALKQQQQLQQQ---QQRDPEAHIKHLLHQRQRRIEEQKEERRR 407
Query: 760 LKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKI 819
++E+Q R E+ + E Q RL++ Q + + Q ++E E Y+ K
Sbjct: 408 VEEQQRR------EREQRKLQE--KEQQRRLEDMQALRREEERRQAEREQE----YKRK- 454
Query: 820 KMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERI----RSLLERQAREI 875
+++ + Q +R R+L+Q + ++L +Q+ +++ LQ ++ +++ R L R +
Sbjct: 455 QLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQ---LQKQQQQQLLPGDRKPLYHYGRGM 511
Query: 876 EAFDSESMRLGFSNMVLSNLSPEA-FSHSYPGASGWSHN-PTGGPGPHWGHPMGGPPQAW 933
D + N + + S PG++G P PGP P Q
Sbjct: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP 571
Query: 934 GHPMQG 939
P +G
Sbjct: 572 VEPQEG 577
Score = 40.4 bits (93), Expect = 0.008
Identities = 42/214 (19%), Positives = 92/214 (42%), Gaps = 31/214 (14%)
Query: 535 KFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKE---------KQEWL 585
+ + HI +KK E ++ EY+ + +++ + + P ++E+L
Sbjct: 301 QLKDHIDRSRKKRG----EKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFL 356
Query: 586 SKQKENIQHFQAEEEANLLRRQRQY---LELECRRFKRRMLLGRHNLEQDLVREELNKRQ 642
Q+EN + +A ++ L++Q+Q ++ +R+ + E+ V E+ + +
Sbjct: 357 RLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRRER 416
Query: 643 TQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRR 702
Q+ L+ R+ E MQ L R + + + + EY +++ E R+
Sbjct: 417 EQRKLQEKEQQRRLEDMQALR---------------REEERRQAEREQEYKRKQLEEQRQ 461
Query: 703 KHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQ 736
++ + Q + K LQ ++Q Q K Q +Q
Sbjct: 462 SERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495
Score = 39.3 bits (90), Expect = 0.019
Identities = 35/154 (22%), Positives = 78/154 (50%), Gaps = 12/154 (7%)
Query: 475 QKQLMTL--ENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAME--KEAKVMS 530
+++ + L ENK +E + + +L + Q+ + A ++ L+ + Q +E KE +
Sbjct: 352 RREFLRLQQENKSNSEALKQQQQLQ---QQQQRDPEAHIKHLLHQRQRRIEEQKEERRRV 408
Query: 531 NEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKE 590
E+++ ++ + Q+KE LE + LR+E+ + + Q +K+ +E +Q E
Sbjct: 409 EEQQRREREQRKLQEKEQQRRLEDMQ---ALRREEERRQAEREQEYKRKQLEE--QRQSE 463
Query: 591 NIQHFQAEEEANLLRRQRQYLELECRRFKRRMLL 624
+Q +E A L Q+Q + + ++ +++ LL
Sbjct: 464 RLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
Score = 38.9 bits (89), Expect = 0.024
Identities = 51/203 (25%), Positives = 83/203 (40%), Gaps = 33/203 (16%)
Query: 709 RQQPKSLKSKELQIKK-QFQDTCKIQTR----------QYKALRNHLLETTPKSEHKAVL 757
R P LKSK+ K F DTC I+T ++ +R+ E + + K +
Sbjct: 247 RNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHI 306
Query: 758 -----KRLKEEQTRKLAILAEQYDHSINE--------------MLSTQALRLDEAQEAEC 798
KR ++E+T +E+ D S E L + LRL + ++
Sbjct: 307 DRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNS 366
Query: 799 QVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQN 858
+ LK Q Q + + ++ IK H R+ R EQ+ RR +Q+ E E LQ
Sbjct: 367 EALKQQQQLQQQQQRDPEAHIK---HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQE 423
Query: 859 ERTERIRSLLERQAREIEAFDSE 881
+ +R ++ RE E +E
Sbjct: 424 KEQQRRLEDMQALRREEERRQAE 446
Score = 37.7 bits (86), Expect = 0.054
Identities = 55/263 (20%), Positives = 114/263 (43%), Gaps = 58/263 (22%)
Query: 551 FLESQKREYKLRKEQLKEELNENQSTPKKEKQ---EWLSKQKENIQHFQAEEEANLLRRQ 607
F+ Q E ++R QLK+ ++ ++ ++++ E+ ++E+ H + E ++++
Sbjct: 288 FIRDQPTERQVRI-QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMN-- 344
Query: 608 RQYLELECRRFKRRMLLGRHNLEQDLVR-EELNKRQTQKDLEHAMLLRQHESMQELEFRH 666
+ G L ++ +R ++ NK ++ + L +Q + E +H
Sbjct: 345 ---------------VPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKH 389
Query: 667 LNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQF 726
L Q+ R R++ Q E ++E +RRERE R+ L+ KE Q ++
Sbjct: 390 L-LHQRQR----RIEEQKEERRRVEEQQRREREQRK------------LQEKEQQ--RRL 430
Query: 727 QDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQ 786
+D +ALR + E + K+L+E++ + Q +H+ + L
Sbjct: 431 EDM--------QALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ-- 480
Query: 787 ALRLDEAQEAECQVLKMQLQQEL 809
Q+ + Q L+ Q QQ+L
Sbjct: 481 -------QQQQQQQLQKQQQQQL 496
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 225 bits (574), Expect = 1e-58
Identities = 174/560 (31%), Positives = 289/560 (51%), Gaps = 88/560 (15%)
Query: 7 AGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQS 66
A SL D +++ L DP +F + +G+G++G VY R V+T ++ AIK M + +
Sbjct: 7 ARSLDDIDLSAL---RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 67 TEKWQDIIKEVKFLQRIKHPNSIE-YKGCYLR------EHTAWLVMEYC-LGSASDLLEV 118
E I +E+ L++ H +I Y G +++ + WLVME+C GS +DL++
Sbjct: 64 EE----IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN 119
Query: 119 HK-KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMAS 177
K L+E IA I L+GLA+LH+H +IHRDIK N+LLTE +VKL DFG ++
Sbjct: 120 TKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD 179
Query: 178 PA----NSFVGTPYWMAPEVILAMDEGQ---YDGKVDVWSLGITCIELAERKPPLFNMNA 230
N+F+GTPYWMAPEVI A DE YD + D+WSLGIT IE+AE PPL +M+
Sbjct: 180 RTVGRRNTFIGTPYWMAPEVI-ACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHP 238
Query: 231 MSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVL 290
M AL+ I +N P L+S +WS F +F+D+CL K RP +E+LLK F+ R++P
Sbjct: 239 MRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI-RDQPTERQ 297
Query: 291 IDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGS 350
+ + + KD +D + ++ +K + ++G EEE+ HG
Sbjct: 298 VRI--QLKD---HIDRSRKKRGEKEETEYEYSG------SEEEDDSHG------------ 334
Query: 351 NQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEG 410
+ SS+ ++P S + E ++ ++ SNS + + ++ +++
Sbjct: 335 ----------EEGEPSSIMNVPGESTLRREFLRLQQEN--KSNSEALK-QQQQLQQQQQR 381
Query: 411 DPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRM 470
DP +H H R R R ++ E+ + EQ +
Sbjct: 382 DPEAHI----------KHLLHQRQR-------------RIEEQKEERRRVEEQQRREREQ 418
Query: 471 RR-QHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKE-AKV 528
R+ Q ++Q LE+ +E R + +++ E +R E ++ ++ Q +++E A +
Sbjct: 419 RKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQL--EEQRQSERLQRQLQQEHAYL 476
Query: 529 MSNEEKKFQQHIQAQQKKEL 548
S ++++ QQ +Q QQ+++L
Sbjct: 477 KSLQQQQQQQQLQKQQQQQL 496
Score = 48.1 bits (113), Expect = 4e-05
Identities = 38/152 (25%), Positives = 77/152 (50%), Gaps = 10/152 (6%)
Query: 512 EKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELN 571
E +++ +++E K ++E K QQ +Q QQ+++ + ++ + + R E+ KEE
Sbjct: 348 ESTLRREFLRLQQENK-SNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERR 406
Query: 572 ENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQ 631
+ ++E+++ ++KE + E+ LRR E E R+ +R R LE+
Sbjct: 407 RVEEQQRREREQRKLQEKEQQRRL---EDMQALRR-----EEERRQAEREQEYKRKQLEE 458
Query: 632 DLVREELNKRQTQKDLEHAMLLRQHESMQELE 663
E L +RQ Q++ + L+Q + Q+L+
Sbjct: 459 QRQSERL-QRQLQQEHAYLKSLQQQQQQQQLQ 489
Score = 43.1 bits (100), Expect = 0.001
Identities = 39/175 (22%), Positives = 97/175 (55%), Gaps = 12/175 (6%)
Query: 402 EEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQ-DSEL 460
E++++ EEG+P +S P + + + R ++ + A +Q+Q+ +Q D E
Sbjct: 329 EDDSHGEEGEP---SSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEA 385
Query: 461 REQMSGYKRMRR--QHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKH 518
+ ++R RR + +++ +E + + E ++ +L+ +K+ + + + A + + ++
Sbjct: 386 HIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQ-EKEQQRRLEDMQA-LRREEERR 443
Query: 519 QAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLES---QKREYKLRKEQLKEEL 570
QA E+E K EE++ + +Q Q ++E +++L+S Q+++ +L+K+Q ++ L
Sbjct: 444 QAEREQEYKRKQLEEQRQSERLQRQLQQE-HAYLKSLQQQQQQQQLQKQQQQQLL 497
Score = 41.6 bits (96), Expect = 0.004
Identities = 34/142 (23%), Positives = 71/142 (50%), Gaps = 21/142 (14%)
Query: 516 KKHQAAMEKEAKVMSNEEKKFQQHIQ----------AQQKKELNSFLESQKREYKLRKEQ 565
K + A++++ ++ +++ + HI+ +QK+E E Q+RE + RK Q
Sbjct: 363 KSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQ 422
Query: 566 LKEELN--ENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRML 623
KE+ E+ ++E++ +++++ + Q EE+ R QRQ L+ E K
Sbjct: 423 EKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQ-LQQEHAYLK---- 477
Query: 624 LGRHNLEQDLVREELNKRQTQK 645
+L+Q +++L K+Q Q+
Sbjct: 478 ----SLQQQQQQQQLQKQQQQQ 495
Score = 40.8 bits (94), Expect = 0.006
Identities = 37/181 (20%), Positives = 83/181 (45%), Gaps = 34/181 (18%)
Query: 657 ESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLK 716
ES EF L K E ++ Q Q L+ ++R+ E KH++ RQ+
Sbjct: 348 ESTLRREFLRLQQENKSNSEALKQQQQ------LQQQQQRDPEAHIKHLLHQRQR----- 396
Query: 717 SKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYD 776
+I++Q ++ +++ +Q + L+ + ++ L+ E+ R+ A ++Y
Sbjct: 397 ----RIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYK 452
Query: 777 HSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQ 836
+L+E +++E +LQ++L+ +AY ++ Q Q ++L++ +Q
Sbjct: 453 RK----------QLEEQRQSE------RLQRQLQQEHAYLKSLQQQ---QQQQQLQKQQQ 493
Query: 837 R 837
+
Sbjct: 494 Q 494
Score = 40.8 bits (94), Expect = 0.006
Identities = 57/246 (23%), Positives = 108/246 (43%), Gaps = 28/246 (11%)
Query: 702 RKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPK--SEHKAVLKR 759
R+ + ++Q+ KS S+ L+ ++Q Q Q R +A HLL + E K +R
Sbjct: 352 RREFLRLQQENKS-NSEALKQQQQLQQQ---QQRDPEAHIKHLLHQRQRRIEEQKEERRR 407
Query: 760 LKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKI 819
++E+Q R E+ + E Q RL++ Q + + Q ++E E Y+ K
Sbjct: 408 VEEQQRR------EREQRKLQE--KEQQRRLEDMQALRREEERRQAEREQE----YKRK- 454
Query: 820 KMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERI----RSLLERQAREI 875
+++ + Q +R R+L+Q + ++L +Q+ +++ LQ ++ +++ R L R +
Sbjct: 455 QLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQ---LQKQQQQQLLPGDRKPLYHYGRGM 511
Query: 876 EAFDSESMRLGFSNMVLSNLSPEA-FSHSYPGASGWSHN-PTGGPGPHWGHPMGGPPQAW 933
D + N + + S PG++G P PGP P Q
Sbjct: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP 571
Query: 934 GHPMQG 939
P +G
Sbjct: 572 VEPQEG 577
Score = 40.4 bits (93), Expect = 0.008
Identities = 42/214 (19%), Positives = 92/214 (42%), Gaps = 31/214 (14%)
Query: 535 KFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKE---------KQEWL 585
+ + HI +KK E ++ EY+ + +++ + + P ++E+L
Sbjct: 301 QLKDHIDRSRKKRG----EKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFL 356
Query: 586 SKQKENIQHFQAEEEANLLRRQRQY---LELECRRFKRRMLLGRHNLEQDLVREELNKRQ 642
Q+EN + +A ++ L++Q+Q ++ +R+ + E+ V E+ + +
Sbjct: 357 RLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRRER 416
Query: 643 TQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRR 702
Q+ L+ R+ E MQ L R + + + + EY +++ E R+
Sbjct: 417 EQRKLQEKEQQRRLEDMQALR---------------REEERRQAEREQEYKRKQLEEQRQ 461
Query: 703 KHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQ 736
++ + Q + K LQ ++Q Q K Q +Q
Sbjct: 462 SERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495
Score = 39.3 bits (90), Expect = 0.019
Identities = 35/154 (22%), Positives = 78/154 (50%), Gaps = 12/154 (7%)
Query: 475 QKQLMTL--ENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAME--KEAKVMS 530
+++ + L ENK +E + + +L + Q+ + A ++ L+ + Q +E KE +
Sbjct: 352 RREFLRLQQENKSNSEALKQQQQLQ---QQQQRDPEAHIKHLLHQRQRRIEEQKEERRRV 408
Query: 531 NEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKE 590
E+++ ++ + Q+KE LE + LR+E+ + + Q +K+ +E +Q E
Sbjct: 409 EEQQRREREQRKLQEKEQQRRLEDMQ---ALRREEERRQAEREQEYKRKQLEE--QRQSE 463
Query: 591 NIQHFQAEEEANLLRRQRQYLELECRRFKRRMLL 624
+Q +E A L Q+Q + + ++ +++ LL
Sbjct: 464 RLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLL 497
Score = 38.9 bits (89), Expect = 0.024
Identities = 51/203 (25%), Positives = 83/203 (40%), Gaps = 33/203 (16%)
Query: 709 RQQPKSLKSKELQIKK-QFQDTCKIQTR----------QYKALRNHLLETTPKSEHKAVL 757
R P LKSK+ K F DTC I+T ++ +R+ E + + K +
Sbjct: 247 RNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHI 306
Query: 758 -----KRLKEEQTRKLAILAEQYDHSINE--------------MLSTQALRLDEAQEAEC 798
KR ++E+T +E+ D S E L + LRL + ++
Sbjct: 307 DRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNS 366
Query: 799 QVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQN 858
+ LK Q Q + + ++ IK H R+ R EQ+ RR +Q+ E E LQ
Sbjct: 367 EALKQQQQLQQQQQRDPEAHIK---HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQE 423
Query: 859 ERTERIRSLLERQAREIEAFDSE 881
+ +R ++ RE E +E
Sbjct: 424 KEQQRRLEDMQALRREEERRQAE 446
Score = 37.7 bits (86), Expect = 0.054
Identities = 55/263 (20%), Positives = 114/263 (43%), Gaps = 58/263 (22%)
Query: 551 FLESQKREYKLRKEQLKEELNENQSTPKKEKQ---EWLSKQKENIQHFQAEEEANLLRRQ 607
F+ Q E ++R QLK+ ++ ++ ++++ E+ ++E+ H + E ++++
Sbjct: 288 FIRDQPTERQVRI-QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMN-- 344
Query: 608 RQYLELECRRFKRRMLLGRHNLEQDLVR-EELNKRQTQKDLEHAMLLRQHESMQELEFRH 666
+ G L ++ +R ++ NK ++ + L +Q + E +H
Sbjct: 345 ---------------VPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKH 389
Query: 667 LNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQF 726
L Q+ R R++ Q E ++E +RRERE R+ L+ KE Q ++
Sbjct: 390 L-LHQRQR----RIEEQKEERRRVEEQQRREREQRK------------LQEKEQQ--RRL 430
Query: 727 QDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQ 786
+D +ALR + E + K+L+E++ + Q +H+ + L
Sbjct: 431 EDM--------QALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ-- 480
Query: 787 ALRLDEAQEAECQVLKMQLQQEL 809
Q+ + Q L+ Q QQ+L
Sbjct: 481 -------QQQQQQQLQKQQQQQL 496
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 225 bits (573), Expect = 2e-58
Identities = 128/281 (45%), Positives = 175/281 (62%), Gaps = 12/281 (4%)
Query: 23 DPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQR 82
DPE+LFT L IG GSFG V+ D RT +VVAIK + +++ ++ +DI +E+ L +
Sbjct: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDL--EEAEDEIEDIQQEITVLSQ 76
Query: 83 IKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYL 142
+Y G YL+ W++MEY LG S L + P E +IA + L+GL YL
Sbjct: 77 CDSSYVTKYYGSYLKGSKLWIIMEY-LGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 135
Query: 143 HSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVILAMD 198
HS IHRDIKA N+LL+E G VKLADFG A + N+FVGTP+WMAPEVI
Sbjct: 136 HSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---Q 192
Query: 199 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFV 258
+ YD K D+WSLGIT IELA+ +PP +M+ M L+ I +N PTL +++ F+ F+
Sbjct: 193 QSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL-VGDFTKSFKEFI 251
Query: 259 DSCLQKIPQDRPTSEELLKHIFVLRERPET-VLIDLIQRTK 298
D+CL K P RPT++ELLKH F+++ +T L +LI R K
Sbjct: 252 DACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFK 292
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 218 bits (555), Expect = 2e-56
Identities = 169/565 (29%), Positives = 275/565 (48%), Gaps = 63/565 (11%)
Query: 23 DPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQR 82
+PE + + E+G G+FG VY A++ T+ + A K + +S E+ +D + E+ L
Sbjct: 29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVID---TKSEEELEDYMVEIDILAS 85
Query: 83 IKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVH-KKPLQEVEIAAITHGALQGLAY 141
HPN ++ + E+ W+++E+C G A D + + ++PL E +I + L L Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 145
Query: 142 LHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVIL-- 195
LH + +IHRD+KAGNIL T G +KLADFG ++ + +SF+GTPYWMAPEV++
Sbjct: 146 LHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCE 205
Query: 196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTL-QSNEWSDYF 254
+ YD K DVWSLGIT IE+AE +PP +N M L IA++E PTL Q + WS F
Sbjct: 206 TSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNF 265
Query: 255 RNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKK 314
++F+ CL+K R T+ +LL+H FV + + + +LI K V E
Sbjct: 266 KDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIR-ELIAEAKAEVTE----------- 313
Query: 315 LLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDV 374
E +G +E+EEE+ S+ SI S SQ++ + L V
Sbjct: 314 ----EVEDG----KEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACI--LESV 363
Query: 375 SDDKSELDMMEGDHTVMSNSSVIHLKP-EEENYREEGDPRTRASDPQSPPQVSRHKSHYR 433
S +K+E E NS +++ KP +E + D +D Q H
Sbjct: 364 S-EKTERSNSED----KLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELH----- 413
Query: 434 NREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHR 493
+ A I+ R E+ D+E +E + + ++TLE + EH
Sbjct: 414 --DRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNI-----EHN 466
Query: 494 LRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLE 553
L+ +++ + ++ KLIK + K+ + + + + +Q+ E + ++
Sbjct: 467 LKSEEEKDQEKQQMFE--NKLIKSEEI---KDTILQTVD-------LVSQETGEKEANIQ 514
Query: 554 SQKREYKLRKEQLKEELNENQSTPK 578
+ E L KE +E+L E+ T K
Sbjct: 515 AVDSEVGLTKEDTQEKLGEDDKTQK 539
Score = 111 bits (278), Expect = 3e-24
Identities = 110/519 (21%), Positives = 234/519 (45%), Gaps = 50/519 (9%)
Query: 354 IPSMSISASSQ---------SSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEE 404
IPS++I++ S S + LP S++ E D G + SS I L
Sbjct: 710 IPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSS-IDLNLSIS 768
Query: 405 NYREEGDPRTRASDPQSPPQVSRHKSHYRNREHF------ATIRTASLVTRQMQEHEQDS 458
++ +T+ S S + R K + F ++ T+ +VT + E+
Sbjct: 769 SFLS----KTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELR 824
Query: 459 ELREQ-MSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKK 517
LR Q + + ++++ Q+ L +KL+ + ++ R ++++ +++ + E+E L K+
Sbjct: 825 FLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQ 884
Query: 518 HQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTP 577
+ +E+ + +N + + I+ +Q+KEL+ F + K + KE +NE + P
Sbjct: 885 QKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKF-------QNMLKNRKKEVINEVEKAP 937
Query: 578 KKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREE 637
K+ ++E + ++KE + Q +E +++Q+Q L+ ++ ++ N+E++ +
Sbjct: 938 KELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLN-- 995
Query: 638 LNKRQTQKDLEHAMLLRQHESMQE---LEFRHLNTIQKMRCELIRLQHQTELTNQLEYNK 694
NK+Q + E A+ + +QE L + L M+ + +H+ E YN+
Sbjct: 996 -NKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQ 1054
Query: 695 RRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHK 754
R EL+ + E + PK +S+ F+ K+LR + T + K
Sbjct: 1055 RLIEELKNRQTQERARLPKIQRSEAKTRMAMFK----------KSLRINSTATPDQDRDK 1104
Query: 755 AVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNA 814
+EE+ +K +A+ H N+M Q EA + L ++ LL
Sbjct: 1105 IKQFAAQEEKRQKNERMAQHQKHE-NQMRDLQL-----QCEANVRELHQLQNEKCHLLVE 1158
Query: 815 YQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEM 853
++++ + + +H +EL+E +++ R+ LE++ ++
Sbjct: 1159 HETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKL 1197
Score = 54.3 bits (129), Expect = 6e-07
Identities = 68/320 (21%), Positives = 136/320 (42%), Gaps = 44/320 (13%)
Query: 378 KSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTR------ASDPQSPPQVSRHKSH 431
K ++ +E +HT +K E+E + + ++ + P+ R +
Sbjct: 886 KQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELM 945
Query: 432 YRNREHFATIRTASLVTR-QMQEHEQDSELRE-------QMSGYKRMRRQHQKQLMTLEN 483
R +E A + A Q Q+ E D L++ +++ +R +++QLM
Sbjct: 946 KRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRARE 1005
Query: 484 KLKAEMDEHRLRLDKDLETQ--RNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQ 541
E++E L+ L Q ++ + + +L+K+H EKE + M ++ + ++
Sbjct: 1006 AAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRH----EKETEQMQRYNQRLIEELK 1061
Query: 542 AQQKKELNSFLESQKREYKLRKEQLKEELNENQS-TP---------------KKEKQEWL 585
+Q +E + Q+ E K R K+ L N + TP K++K E +
Sbjct: 1062 NRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERM 1121
Query: 586 S---KQKENIQHFQAEEEANL-----LRRQRQYLELECRRFKRRMLLGRHNLEQDLVREE 637
+ K + ++ Q + EAN+ L+ ++ +L +E K + L H+ E RE+
Sbjct: 1122 AQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREK 1181
Query: 638 LNKRQTQKDLEHAMLLRQHE 657
L R+ + E A L++ E
Sbjct: 1182 LRPRKKTLEEEFARKLQEQE 1201
Score = 31.6 bits (70), Expect = 3.9
Identities = 35/167 (20%), Positives = 67/167 (40%), Gaps = 25/167 (14%)
Query: 448 TRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNN- 506
T QMQ + Q L E++ + R ++ E K + M + LR++ ++
Sbjct: 1046 TEQMQRYNQ--RLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRD 1103
Query: 507 ----FAAEMEKLIK--------KHQAAME----------KEAKVMSNEEKKFQQHIQAQQ 544
FAA+ EK K KH+ M +E + NE+ + Q+
Sbjct: 1104 KIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQK 1163
Query: 545 KKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKEN 591
KEL+ + +E++ + K+ L E + +E++ + E+
Sbjct: 1164 LKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGES 1210
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 214 bits (545), Expect = 3e-55
Identities = 117/287 (40%), Positives = 179/287 (62%), Gaps = 12/287 (4%)
Query: 21 KEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFL 80
+ +P++ F ++ IG G++G VY AR+V T E+ AIK + + E + + +E+ +
Sbjct: 9 RRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKL---EPGEDFAVVQQEIIMM 65
Query: 81 QRIKHPNSIEYKGCYLREHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAITHGALQGL 139
+ KHPN + Y G YLR W+ ME+C G S D+ V PL E++IA ++ LQGL
Sbjct: 66 KDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHV-TGPLSELQIAYVSRETLQGL 124
Query: 140 AYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVIL 195
YLHS +HRDIK NILLT+ G VKLADFG ++ + SF+GTPYWMAPEV
Sbjct: 125 YYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAA 184
Query: 196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN--ESPTLQSN-EWSD 252
+G Y+ D+W++GIT IELAE +PP+F+++ M AL+ + ++ + P L+ +WS+
Sbjct: 185 VERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSN 244
Query: 253 YFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKD 299
F +FV L K P+ RPT+E+LL+H FV + ++ I+L+ + +
Sbjct: 245 SFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNN 291
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 211 bits (537), Expect = 3e-54
Identities = 117/286 (40%), Positives = 169/286 (59%), Gaps = 12/286 (4%)
Query: 22 EDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQ 81
+DP F L+ +G G++G VY ARD T+E+ A+K + Q +E+ L+
Sbjct: 10 QDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQ---QEITILR 66
Query: 82 RIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAY 141
+HPN + Y G YLR W+ ME+C G + + PL+E +IA + AL+GL +
Sbjct: 67 ECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHH 126
Query: 142 LHSHTMIHRDIKAGNILLTEPGQVKLADFG-----SASMASPANSFVGTPYWMAPEVILA 196
LHS IHRDIK N+LLT G VKLADFG +AS+A SF+GTPYWMAPEV
Sbjct: 127 LHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAK-RRSFIGTPYWMAPEVAAV 185
Query: 197 MDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN--ESPTLQ-SNEWSDY 253
+G Y+ DVW+LGIT IEL E +PPLF+++ M AL ++++ + P L+ W+
Sbjct: 186 ERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQN 245
Query: 254 FRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKD 299
F +F+ L K P+ RPT+E+LL+H F ++ P +L L+ + D
Sbjct: 246 FHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASD 291
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 204 bits (518), Expect = 4e-52
Identities = 123/286 (43%), Positives = 170/286 (59%), Gaps = 14/286 (4%)
Query: 23 DPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQR 82
DP+K +T +IG G+ G VY A DV T + VAIK+M+ Q K + II E+ ++
Sbjct: 265 DPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNL---QQQPKKELIINEILVMRE 321
Query: 83 IKHPNSIEYKGCYLREHTAWLVMEYCLG-SASDLLEVHKKPLQEVEIAAITHGALQGLAY 141
K+PN + Y YL W+VMEY G S +D+ V + + E +IAA+ LQ L +
Sbjct: 322 NKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDV--VTETCMDEGQIAAVCRECLQALEF 379
Query: 142 LHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANS----FVGTPYWMAPEVILAM 197
LHS+ +IHRDIK+ NILL G VKL DFG + +P S VGTPYWMAPEV+
Sbjct: 380 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV--- 436
Query: 198 DEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNE-WSDYFRN 256
Y KVD+WSLGI IE+ E +PP N N + ALY IA N +P LQ+ E S FR+
Sbjct: 437 TRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRD 496
Query: 257 FVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVR 302
F++ CL+ + R +++ELL+H F+ +P + L LI K+A +
Sbjct: 497 FLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK 542
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.361
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,955,318
Number of Sequences: 37866
Number of extensions: 2024268
Number of successful extensions: 23355
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 916
Number of HSP's successfully gapped in prelim test: 1387
Number of HSP's that attempted gapping in prelim test: 9608
Number of HSP's gapped (non-prelim): 6957
length of query: 1001
length of database: 18,247,518
effective HSP length: 112
effective length of query: 889
effective length of database: 14,006,526
effective search space: 12451801614
effective search space used: 12451801614
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.