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Search of human proteins with 4505657
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]
(941 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens] 1899 0.0
gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens] 1848 0.0
gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens] 1848 0.0
gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens] 362 1e-99
gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens] 349 8e-96
gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens] 329 6e-90
gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens] 329 6e-90
gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens] 320 5e-87
gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens] 303 5e-82
gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens] 288 2e-77
gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens] 288 2e-77
gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens] 288 2e-77
gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens] 283 4e-76
gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens] 282 1e-75
gi|157364939 phosphodiesterase 6C [Homo sapiens] 259 1e-68
gi|170650674 phosphodiesterase 6A [Homo sapiens] 256 9e-68
gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens] 249 8e-66
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 156 7e-38
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 156 7e-38
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 156 7e-38
gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens] 156 7e-38
gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens] 156 7e-38
gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens] 156 7e-38
gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens] 156 7e-38
gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens] 156 7e-38
gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens] 156 7e-38
gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens] 156 7e-38
gi|48762734 phosphodiesterase 9A isoform i [Homo sapiens] 156 7e-38
gi|48762732 phosphodiesterase 9A isoform h [Homo sapiens] 156 7e-38
gi|48762730 phosphodiesterase 9A isoform g [Homo sapiens] 156 7e-38
>gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]
Length = 941
Score = 1899 bits (4919), Expect = 0.0
Identities = 941/941 (100%), Positives = 941/941 (100%)
Query: 1 MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI 60
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
Sbjct: 1 MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI 60
Query: 61 SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN 120
SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN
Sbjct: 61 SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN 120
Query: 121 GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV 180
GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV
Sbjct: 121 GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV 180
Query: 181 EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL 240
EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL
Sbjct: 181 EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL 240
Query: 241 DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV 300
DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV
Sbjct: 241 DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV 300
Query: 301 EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD 360
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
Sbjct: 301 EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD 360
Query: 361 EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE 420
EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
Sbjct: 361 EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE 420
Query: 421 ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD 480
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
Sbjct: 421 ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD 480
Query: 481 AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF 540
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
Sbjct: 481 AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF 540
Query: 541 SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF 600
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF
Sbjct: 541 SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF 600
Query: 601 ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH 660
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
Sbjct: 601 ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH 660
Query: 661 AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS 720
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
Sbjct: 661 AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS 720
Query: 721 SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL 780
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
Sbjct: 721 SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL 780
Query: 781 QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM 840
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
Sbjct: 781 QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM 840
Query: 841 GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH 900
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH
Sbjct: 841 GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH 900
Query: 901 KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE 941
KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
Sbjct: 901 KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE 941
>gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]
Length = 932
Score = 1848 bits (4788), Expect = 0.0
Identities = 918/920 (99%), Positives = 918/920 (99%)
Query: 22 AEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETV 81
A RGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETV
Sbjct: 13 AHRRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETV 72
Query: 82 YTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAP 141
YTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAP
Sbjct: 73 YTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAP 132
Query: 142 DTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPRE 201
DTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPRE
Sbjct: 133 DTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPRE 192
Query: 202 APRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASR 261
APRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASR
Sbjct: 193 APRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASR 252
Query: 262 CCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQS 321
CCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQS
Sbjct: 253 CCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQS 312
Query: 322 MLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTL 381
MLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTL
Sbjct: 313 MLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTL 372
Query: 382 AFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELV 441
AFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELV
Sbjct: 373 AFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELV 432
Query: 442 AKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRN 501
AKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRN
Sbjct: 433 AKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRN 492
Query: 502 ILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQ 561
ILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQ
Sbjct: 493 ILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQ 552
Query: 562 YRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILS 621
YRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILS
Sbjct: 553 YRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILS 612
Query: 622 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 681
MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL
Sbjct: 613 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 672
Query: 682 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 741
EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH
Sbjct: 673 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 732
Query: 742 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 801
GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC
Sbjct: 733 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 792
Query: 802 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 861
LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS
Sbjct: 793 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 852
Query: 862 FMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYE 921
FMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYE
Sbjct: 853 FMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYE 912
Query: 922 VPDLDGTRAPINGCCSLDAE 941
VPDLDGTRAPINGCCSLDAE
Sbjct: 913 VPDLDGTRAPINGCCSLDAE 932
>gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]
Length = 934
Score = 1848 bits (4786), Expect = 0.0
Identities = 917/917 (100%), Positives = 917/917 (100%)
Query: 25 RGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTY 84
RGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTY
Sbjct: 18 RGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTY 77
Query: 85 LLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQ 144
LLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQ
Sbjct: 78 LLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQ 137
Query: 145 VLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPR 204
VLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPR
Sbjct: 138 VLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPR 197
Query: 205 AVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCL 264
AVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCL
Sbjct: 198 AVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCL 257
Query: 265 LLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLG 324
LLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLG
Sbjct: 258 LLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLG 317
Query: 325 CELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQ 384
CELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQ
Sbjct: 318 CELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQ 377
Query: 385 KEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKV 444
KEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKV
Sbjct: 378 KEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKV 437
Query: 445 FDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILC 504
FDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILC
Sbjct: 438 FDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILC 497
Query: 505 FPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRS 564
FPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRS
Sbjct: 498 FPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRS 557
Query: 565 HLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ 624
HLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ
Sbjct: 558 HLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ 617
Query: 625 DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDI 684
DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDI
Sbjct: 618 DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDI 677
Query: 685 EIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCN 744
EIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCN
Sbjct: 678 EIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCN 737
Query: 745 IFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLM 804
IFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLM
Sbjct: 738 IFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLM 797
Query: 805 TSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFME 864
TSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFME
Sbjct: 798 TSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFME 857
Query: 865 HIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPD 924
HIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPD
Sbjct: 858 HIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPD 917
Query: 925 LDGTRAPINGCCSLDAE 941
LDGTRAPINGCCSLDAE
Sbjct: 918 LDGTRAPINGCCSLDAE 934
>gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]
Length = 933
Score = 362 bits (928), Expect = 1e-99
Identities = 229/722 (31%), Positives = 368/722 (50%), Gaps = 64/722 (8%)
Query: 239 DLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGC--- 295
DLD +SL K+L ++ A RC L LV + K + K PL C
Sbjct: 215 DLDLTSLSYKILIFVCLMVDADRCSLFLV--EGAAAGKKTLVSKFFDVHAGTPLLPCSST 272
Query: 296 --------------LGQVVEDKKSIQLKDLTSEDV--QQLQSMLGCELQAMLCVPVISRA 339
+G V E +++ + D + ++ + G + +++LC+P+ S +
Sbjct: 273 ENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRS-S 331
Query: 340 TDQVVALACAFNKL-EGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQ 398
+++ +A A NK+ EG FT++DE V+Q + +++ F +K +ALL+
Sbjct: 332 DGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLE 391
Query: 399 VAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIR 458
V +LF D+ ++++I+ A+ L E CSV LL+ E F +S+E+
Sbjct: 392 VVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFT------KSFELM 445
Query: 459 IPA-----------------------DQGIAGHVATTGQILNIPDAYAHPLFYRGVDDST 495
P + IA VA+TG +NI DAY P F D +
Sbjct: 446 SPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQIS 505
Query: 496 GFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYK 555
GF R++LC PI N N ++IGVA+++N+++G F D+ L AF I+CG+ I ++++Y
Sbjct: 506 GFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYD 565
Query: 556 KVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAI---DSNFASFTYTPRSLPE 612
+V ++ + +A +++ YH S E K I V+ + D +F F SL
Sbjct: 566 QVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDF-----SLDV 620
Query: 613 DDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLY 672
D A L M ++ + +KID TL R+ L V+K YR YHNW HAF+V + +
Sbjct: 621 DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAML 680
Query: 673 KNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFA 732
+ L ++EI A+ + C+CHDLDHRGTNN+FQ S S LA LY + + +E HHF
Sbjct: 681 TTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGT-SATLEHHHFN 739
Query: 733 QAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRN 791
A+ IL + G NIF + S K+Y ++ L++ ILATDL + + ++ G YD N
Sbjct: 740 HAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWN 799
Query: 792 NKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDR 850
K H + +LMT+CDL TK W+ +R++AEL+ EFF QGD E+ + P + DR
Sbjct: 800 IKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDR 859
Query: 851 -EKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPS 909
K +P LQ+ +++ I MP+Y+ L + K + + VA+NR W ++ K + S
Sbjct: 860 NRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTAS 919
Query: 910 NN 911
++
Sbjct: 920 SS 921
>gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]
Length = 683
Score = 349 bits (895), Expect = 8e-96
Identities = 210/639 (32%), Positives = 340/639 (53%), Gaps = 45/639 (7%)
Query: 303 KKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKL-EGDLFTDE 361
++ + KD D ++ + G + +++LC+P+ S + +++ +A A NK+ EG FT++
Sbjct: 48 QRQTKTKDRRFND--EIDKLTGYKTKSLLCMPIRS-SDGEIIGVAQAINKIPEGAPFTED 104
Query: 362 DEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEA 421
DE V+Q + +++ F +K +ALL+V +LF D+ ++++I+ A
Sbjct: 105 DEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRA 164
Query: 422 RNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPA-------------------- 461
+ L E CSV LL+ E F +S+E+ P
Sbjct: 165 QTLLKCERCSVLLLEDIESPVVKFT------KSFELMSPKCSADAENSFKESMEKSSYSD 218
Query: 462 ---DQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVA 518
+ IA VA+TG +NI DAY P F D +GF R++LC PI N N ++IGVA
Sbjct: 219 WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVA 278
Query: 519 ELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVS 578
+++N+++G F D+ L AF I+CG+ I ++++Y +V ++ + +A +++ YH S
Sbjct: 279 QVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCS 338
Query: 579 DDEYTKLLHDGIQPVAAI---DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKID 635
E K I V+ + D +F F SL D A L M ++ + +KID
Sbjct: 339 KAEVDKFKAANIPLVSELAIDDIHFDDF-----SLDVDAMITAALRMFMELGMVQKFKID 393
Query: 636 CPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMC 695
TL R+ L V+K YR YHNW HAF+V + + + L ++EI A+ + C+C
Sbjct: 394 YETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLC 453
Query: 696 HDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQ 755
HDLDHRGTNN+FQ S S LA LY + + +E HHF A+ IL + G NIF + S K+Y
Sbjct: 454 HDLDHRGTNNAFQAKSGSALAQLYGT-SATLEHHHFNHAVMILQSEGHNIFANLSSKEYS 512
Query: 756 RMLDLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTK 814
++ L++ ILATDL + + ++ G YD N K H + +LMT+CDL TK
Sbjct: 513 DLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTK 572
Query: 815 GWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDR-EKAYIPELQISFMEHIAMPIYK 872
W+ +R++AEL+ EFF QGD E+ + P + DR K +P LQ+ +++ I MP+Y+
Sbjct: 573 PWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQ 632
Query: 873 LLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNN 911
L + K + + VA+NR W ++ K + S++
Sbjct: 633 ALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSS 671
>gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]
Length = 779
Score = 329 bits (844), Expect = 6e-90
Identities = 208/622 (33%), Positives = 330/622 (53%), Gaps = 43/622 (6%)
Query: 299 VVEDKKSIQLKDLTSEDVQQLQSML--GCELQAMLCVPVISRATDQVVALACAFNKLEGD 356
V + +K++ ++D+ ++ + L G +Q++LC+P+++ D ++ + + +
Sbjct: 155 VAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGD-LIGILELYRHWGKE 213
Query: 357 LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQE 416
F + V + S + + K LL V+K F ++ + LL+
Sbjct: 214 AFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEH 273
Query: 417 IITEARNLSNAEICSVFLLDQN--ELVAKVFD------GGVVDDESYEIRIPADQGIAGH 468
I+ A+NL NA+ C++F +D EL + +FD G V ++ EIR ++GIAG
Sbjct: 274 IMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQ 333
Query: 469 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 528
VA TG++LNIPDAYA P F R VD TG+ TRNILC PI + VIGV ++VNKI+G
Sbjct: 334 VARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRG-SVIGVVQMVNKISGSA 392
Query: 529 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 588
FSK DE+ F+++C +++ + +Y ++ ++ + E + YH + +E+ L+
Sbjct: 393 FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM-- 450
Query: 589 GIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDM---NFINNYKIDCPT------- 638
FT R E + + ++M F+ C T
Sbjct: 451 -------------QFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEK 497
Query: 639 LARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDL 698
L RF + VKK YR PYHNW HA +V+H Y + +N D+E L I+C+CHDL
Sbjct: 498 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDL 555
Query: 699 DHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRML 758
DHRG +NS+ LAALYS+ S ME+HHF+Q ++IL G NIF S +Y+++L
Sbjct: 556 DHRGFSNSYLQKFDHPLAALYST--STMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVL 613
Query: 759 DLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWK 817
+++R I+ATDLA + K L++M + G + NN+ H ++ L+MT+CDL TK W
Sbjct: 614 EIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP 673
Query: 818 TTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQD 876
T+ A IY EF+++GD K +G +P+ MMDR+K +P+ Q+ F +A+P Y L
Sbjct: 674 VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQ 733
Query: 877 LFPKAAELYERVASNREHWTKV 898
+ P L + N W KV
Sbjct: 734 ILPPTEPLLKACRDNLSQWEKV 755
Score = 40.0 bits (92), Expect = 0.010
Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 2/91 (2%)
Query: 460 PADQG--IAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGV 517
P QG ++ +VA + + L + D F RG +G R +++LC PI ++IG+
Sbjct: 144 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 203
Query: 518 AELVNKINGPWFSKFDEDLATAFSIYCGISI 548
EL F +++ATA + ++I
Sbjct: 204 LELYRHWGKEAFCLSHQEVATANLAWASVAI 234
>gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]
Length = 789
Score = 329 bits (844), Expect = 6e-90
Identities = 208/622 (33%), Positives = 330/622 (53%), Gaps = 43/622 (6%)
Query: 299 VVEDKKSIQLKDLTSEDVQQLQSML--GCELQAMLCVPVISRATDQVVALACAFNKLEGD 356
V + +K++ ++D+ ++ + L G +Q++LC+P+++ D ++ + + +
Sbjct: 165 VAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGD-LIGILELYRHWGKE 223
Query: 357 LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQE 416
F + V + S + + K LL V+K F ++ + LL+
Sbjct: 224 AFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEH 283
Query: 417 IITEARNLSNAEICSVFLLDQN--ELVAKVFD------GGVVDDESYEIRIPADQGIAGH 468
I+ A+NL NA+ C++F +D EL + +FD G V ++ EIR ++GIAG
Sbjct: 284 IMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQ 343
Query: 469 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 528
VA TG++LNIPDAYA P F R VD TG+ TRNILC PI + VIGV ++VNKI+G
Sbjct: 344 VARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRG-SVIGVVQMVNKISGSA 402
Query: 529 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 588
FSK DE+ F+++C +++ + +Y ++ ++ + E + YH + +E+ L+
Sbjct: 403 FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM-- 460
Query: 589 GIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDM---NFINNYKIDCPT------- 638
FT R E + + ++M F+ C T
Sbjct: 461 -------------QFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEK 507
Query: 639 LARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDL 698
L RF + VKK YR PYHNW HA +V+H Y + +N D+E L I+C+CHDL
Sbjct: 508 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDL 565
Query: 699 DHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRML 758
DHRG +NS+ LAALYS+ S ME+HHF+Q ++IL G NIF S +Y+++L
Sbjct: 566 DHRGFSNSYLQKFDHPLAALYST--STMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVL 623
Query: 759 DLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWK 817
+++R I+ATDLA + K L++M + G + NN+ H ++ L+MT+CDL TK W
Sbjct: 624 EIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP 683
Query: 818 TTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQD 876
T+ A IY EF+++GD K +G +P+ MMDR+K +P+ Q+ F +A+P Y L
Sbjct: 684 VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQ 743
Query: 877 LFPKAAELYERVASNREHWTKV 898
+ P L + N W KV
Sbjct: 744 ILPPTEPLLKACRDNLSQWEKV 765
Score = 40.0 bits (92), Expect = 0.010
Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 2/91 (2%)
Query: 460 PADQG--IAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGV 517
P QG ++ +VA + + L + D F RG +G R +++LC PI ++IG+
Sbjct: 154 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 213
Query: 518 AELVNKINGPWFSKFDEDLATAFSIYCGISI 548
EL F +++ATA + ++I
Sbjct: 214 LELYRHWGKEAFCLSHQEVATANLAWASVAI 244
>gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]
Length = 575
Score = 320 bits (819), Expect = 5e-87
Identities = 190/569 (33%), Positives = 299/569 (52%), Gaps = 41/569 (7%)
Query: 372 YTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICS 431
+ +++ F +K +ALL+V +LF D+ ++++I+ A+ L E CS
Sbjct: 7 FCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCS 66
Query: 432 VFLLDQNELVAKVFDGGVVDDESYEIRIPA-----------------------DQGIAGH 468
V LL+ E F +S+E+ P + IA
Sbjct: 67 VLLLEDIESPVVKFT------KSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL 120
Query: 469 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 528
VA+TG +NI DAY P F D +GF R++LC PI N N ++IGVA+++N+++G
Sbjct: 121 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 180
Query: 529 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 588
F D+ L AF I+CG+ I ++++Y +V ++ + +A +++ YH S E K
Sbjct: 181 FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA 240
Query: 589 GIQPVAAI---DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLM 645
I V+ + D +F F SL D A L M ++ + +KID TL R+ L
Sbjct: 241 NIPLVSELAIDDIHFDDF-----SLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLT 295
Query: 646 VKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNN 705
V+K YR YHNW HAF+V + + + L ++EI A+ + C+CHDLDHRGTNN
Sbjct: 296 VRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNN 355
Query: 706 SFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDII 765
+FQ S S LA LY + + +E HHF A+ IL + G NIF + S K+Y ++ L++ I
Sbjct: 356 AFQAKSGSALAQLYGT-SATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSI 414
Query: 766 LATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE 824
LATDL + + ++ G YD N K H + +LMT+CDL TK W+ +R++AE
Sbjct: 415 LATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAE 474
Query: 825 LIYKEFFSQGDLEK-AMGNRPMEMMDR-EKAYIPELQISFMEHIAMPIYKLLQDLFPKAA 882
L+ EFF QGD E+ + P + DR K +P LQ+ +++ I MP+Y+ L + K
Sbjct: 475 LVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLK 534
Query: 883 ELYERVASNREHWTKVSHKFTIRGLPSNN 911
+ + VA+NR W ++ K + S++
Sbjct: 535 PMLDSVATNRSKWEELHQKRLLASTASSS 563
Score = 37.0 bits (84), Expect = 0.087
Identities = 34/187 (18%), Positives = 79/187 (42%), Gaps = 24/187 (12%)
Query: 225 DRDRKILQLCGELYD--LDASSLQLKVLQYLQQETRASRCCLLLVSE------------D 270
+R R +L++ +L++ D + K++ Q + RC +LL+ + +
Sbjct: 26 ERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFE 85
Query: 271 NLQLSCKVIGDKVLGEEV---SFPLTGCLGQVVEDKKSIQLKDLTSEDVQ------QLQS 321
+ C + E + S+ + E S L S+ Q +
Sbjct: 86 LMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQ 145
Query: 322 MLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTL 381
+ G ++++LCVP+ + + Q++ +A N+L+G F D D+ + + + + +T+
Sbjct: 146 ISGFHIRSVLCVPIWN-SNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTI 204
Query: 382 AFQKEQK 388
+ + +K
Sbjct: 205 MYDQVKK 211
>gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]
Length = 489
Score = 303 bits (776), Expect = 5e-82
Identities = 167/456 (36%), Positives = 257/456 (56%), Gaps = 12/456 (2%)
Query: 462 DQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELV 521
+ IA VA+TG +NI DAY P F D +GF R++LC PI N N ++IGVA+++
Sbjct: 28 NNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVL 87
Query: 522 NKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDE 581
N+++G F D+ L AF I+CG+ I ++++Y +V ++ + +A +++ YH S E
Sbjct: 88 NRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAE 147
Query: 582 YTKLLHDGIQPVAAI---DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPT 638
K I V+ + D +F F SL D A L M ++ + +KID T
Sbjct: 148 VDKFKAANIPLVSELAIDDIHFDDF-----SLDVDAMITAALRMFMELGMVQKFKIDYET 202
Query: 639 LARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDL 698
L R+ L V+K YR YHNW HAF+V + + + L ++EI A+ + C+CHDL
Sbjct: 203 LCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDL 262
Query: 699 DHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRML 758
DHRGTNN+FQ S S LA LY + + +E HHF A+ IL + G NIF + S K+Y ++
Sbjct: 263 DHRGTNNAFQAKSGSALAQLYGT-SATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLM 321
Query: 759 DLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWK 817
L++ ILATDL + + ++ G YD N K H + +LMT+CDL TK W+
Sbjct: 322 QLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWE 381
Query: 818 TTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDR-EKAYIPELQISFMEHIAMPIYKLLQ 875
+R++AEL+ EFF QGD E+ + P + DR K +P LQ+ +++ I MP+Y+ L
Sbjct: 382 ISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALV 441
Query: 876 DLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNN 911
+ K + + VA+NR W ++ K + S++
Sbjct: 442 KVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSS 477
Score = 35.0 bits (79), Expect = 0.33
Identities = 15/65 (23%), Positives = 37/65 (56%), Gaps = 1/65 (1%)
Query: 324 GCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAF 383
G ++++LCVP+ + + Q++ +A N+L+G F D D+ + + + + +T+ +
Sbjct: 62 GFHIRSVLCVPIWN-SNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMY 120
Query: 384 QKEQK 388
+ +K
Sbjct: 121 DQVKK 125
>gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]
Length = 875
Score = 288 bits (737), Expect = 2e-77
Identities = 214/718 (29%), Positives = 362/718 (50%), Gaps = 46/718 (6%)
Query: 225 DRDRKILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSED--NLQLSCKVIGD 281
D+ ++L+L ++ LD ++L K+ ++ A R L LV ED N + + D
Sbjct: 147 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 206
Query: 282 KVLG---EEVSFPLT------GCLGQVVEDKKSIQLKDLTSEDVQ---QLQSMLGCELQA 329
G EEVS G +G V + + +KD ED + ++ + G + Q+
Sbjct: 207 VAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKD-AYEDPRFNAEVDQITGYKTQS 265
Query: 330 MLCVPVISRATDQVVALACAFNKLEGD--LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQ 387
+LC+P I ++VV +A A NK G+ FT++DE + VL + ++
Sbjct: 266 ILCMP-IKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSL 324
Query: 388 KLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN--ELVAKVF 445
Q LL +A +F + V+L++I + + C++F++D++ + + VF
Sbjct: 325 LENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVF 384
Query: 446 DGGVVDDESYEIRIPADQGI-------AGHVATTGQILNIPDAYAHPLFYRGVDDSTGFR 498
+ E + + A +V T + LNIPD F +++
Sbjct: 385 HMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVN 444
Query: 499 T---RNILCFPIKN-ENQEVIGVAELVNKINGPW-----FSKFDEDLATAFSIYCGISIA 549
R++LC PIKN + +VIGV +LVNK+ F++ DE AF I+CG+ I
Sbjct: 445 QQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQ 504
Query: 550 HSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKL--LHDGIQPVAAIDSNFASFTYTP 607
++ +Y+ V A + + E++ YH +++E +L L + P +A F+++
Sbjct: 505 NTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVP-SAQTLKITDFSFSD 563
Query: 608 RSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYR-DPPYHNWMHAFSVSH 666
L + +T++ + M D+N + N+++ L R+ L VKK YR + YHNW HAF+ +
Sbjct: 564 FELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQ 623
Query: 667 FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM 726
+ K ++ N L D+EI AL I+ + HDLDHRG NNS+ S+ LA LY S+M
Sbjct: 624 CMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH--SIM 681
Query: 727 ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL-RIFKDLQKMAE 785
E HHF Q + ILN+ G I S ++Y+ L +++ ILATDLA ++ R + + + +
Sbjct: 682 EHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK 741
Query: 786 VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLE-KAMGNRP 844
++ + L L +LMT+CDLS TK W ++IAEL+ EFF QGD E K + P
Sbjct: 742 NQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEP 801
Query: 845 MEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHK 901
++M+REK IP +Q+ F++ I + +Y+ L + L + NR+ W ++ +
Sbjct: 802 TDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
>gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]
Length = 823
Score = 288 bits (737), Expect = 2e-77
Identities = 214/718 (29%), Positives = 362/718 (50%), Gaps = 46/718 (6%)
Query: 225 DRDRKILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSED--NLQLSCKVIGD 281
D+ ++L+L ++ LD ++L K+ ++ A R L LV ED N + + D
Sbjct: 95 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 154
Query: 282 KVLG---EEVSFPLT------GCLGQVVEDKKSIQLKDLTSEDVQ---QLQSMLGCELQA 329
G EEVS G +G V + + +KD ED + ++ + G + Q+
Sbjct: 155 VAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKD-AYEDPRFNAEVDQITGYKTQS 213
Query: 330 MLCVPVISRATDQVVALACAFNKLEGD--LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQ 387
+LC+P I ++VV +A A NK G+ FT++DE + VL + ++
Sbjct: 214 ILCMP-IKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSL 272
Query: 388 KLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN--ELVAKVF 445
Q LL +A +F + V+L++I + + C++F++D++ + + VF
Sbjct: 273 LENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVF 332
Query: 446 DGGVVDDESYEIRIPADQGI-------AGHVATTGQILNIPDAYAHPLFYRGVDDSTGFR 498
+ E + + A +V T + LNIPD F +++
Sbjct: 333 HMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVN 392
Query: 499 T---RNILCFPIKN-ENQEVIGVAELVNKINGPW-----FSKFDEDLATAFSIYCGISIA 549
R++LC PIKN + +VIGV +LVNK+ F++ DE AF I+CG+ I
Sbjct: 393 QQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQ 452
Query: 550 HSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKL--LHDGIQPVAAIDSNFASFTYTP 607
++ +Y+ V A + + E++ YH +++E +L L + P +A F+++
Sbjct: 453 NTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVP-SAQTLKITDFSFSD 511
Query: 608 RSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYR-DPPYHNWMHAFSVSH 666
L + +T++ + M D+N + N+++ L R+ L VKK YR + YHNW HAF+ +
Sbjct: 512 FELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQ 571
Query: 667 FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM 726
+ K ++ N L D+EI AL I+ + HDLDHRG NNS+ S+ LA LY S+M
Sbjct: 572 CMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH--SIM 629
Query: 727 ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL-RIFKDLQKMAE 785
E HHF Q + ILN+ G I S ++Y+ L +++ ILATDLA ++ R + + + +
Sbjct: 630 EHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK 689
Query: 786 VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLE-KAMGNRP 844
++ + L L +LMT+CDLS TK W ++IAEL+ EFF QGD E K + P
Sbjct: 690 NQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEP 749
Query: 845 MEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHK 901
++M+REK IP +Q+ F++ I + +Y+ L + L + NR+ W ++ +
Sbjct: 750 TDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 807
>gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]
Length = 833
Score = 288 bits (737), Expect = 2e-77
Identities = 214/718 (29%), Positives = 362/718 (50%), Gaps = 46/718 (6%)
Query: 225 DRDRKILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSED--NLQLSCKVIGD 281
D+ ++L+L ++ LD ++L K+ ++ A R L LV ED N + + D
Sbjct: 105 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 164
Query: 282 KVLG---EEVSFPLT------GCLGQVVEDKKSIQLKDLTSEDVQ---QLQSMLGCELQA 329
G EEVS G +G V + + +KD ED + ++ + G + Q+
Sbjct: 165 VAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKD-AYEDPRFNAEVDQITGYKTQS 223
Query: 330 MLCVPVISRATDQVVALACAFNKLEGD--LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQ 387
+LC+P I ++VV +A A NK G+ FT++DE + VL + ++
Sbjct: 224 ILCMP-IKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSL 282
Query: 388 KLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN--ELVAKVF 445
Q LL +A +F + V+L++I + + C++F++D++ + + VF
Sbjct: 283 LENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVF 342
Query: 446 DGGVVDDESYEIRIPADQGI-------AGHVATTGQILNIPDAYAHPLFYRGVDDSTGFR 498
+ E + + A +V T + LNIPD F +++
Sbjct: 343 HMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVN 402
Query: 499 T---RNILCFPIKN-ENQEVIGVAELVNKINGPW-----FSKFDEDLATAFSIYCGISIA 549
R++LC PIKN + +VIGV +LVNK+ F++ DE AF I+CG+ I
Sbjct: 403 QQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQ 462
Query: 550 HSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKL--LHDGIQPVAAIDSNFASFTYTP 607
++ +Y+ V A + + E++ YH +++E +L L + P +A F+++
Sbjct: 463 NTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVP-SAQTLKITDFSFSD 521
Query: 608 RSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYR-DPPYHNWMHAFSVSH 666
L + +T++ + M D+N + N+++ L R+ L VKK YR + YHNW HAF+ +
Sbjct: 522 FELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQ 581
Query: 667 FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM 726
+ K ++ N L D+EI AL I+ + HDLDHRG NNS+ S+ LA LY S+M
Sbjct: 582 CMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH--SIM 639
Query: 727 ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL-RIFKDLQKMAE 785
E HHF Q + ILN+ G I S ++Y+ L +++ ILATDLA ++ R + + + +
Sbjct: 640 EHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK 699
Query: 786 VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLE-KAMGNRP 844
++ + L L +LMT+CDLS TK W ++IAEL+ EFF QGD E K + P
Sbjct: 700 NQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEP 759
Query: 845 MEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHK 901
++M+REK IP +Q+ F++ I + +Y+ L + L + NR+ W ++ +
Sbjct: 760 TDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 817
>gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]
Length = 853
Score = 283 bits (725), Expect = 4e-76
Identities = 217/806 (26%), Positives = 375/806 (46%), Gaps = 109/806 (13%)
Query: 230 ILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSEDN--LQLSCKVIG---DKV 283
+L+L ++ + ++ + KVL+ L +A RC L + + N +L+ ++ D V
Sbjct: 59 LLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSV 118
Query: 284 LGE-------EVSFPLT-GCLGQVVEDKKSIQLKDLTS--EDVQQLQSMLGCELQAMLCV 333
L + E+ FPL G +G V + KK + ++D+ + + + ML
Sbjct: 119 LEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLAT 178
Query: 334 PVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCEC 393
P+++ VVA+ A NKL G FT EDE V ++ + L + CE
Sbjct: 179 PIMNGK--DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLK---IYHLSYLHNCET 233
Query: 394 ---QALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNE----------- 439
Q LL A +F L D+ + R N E SV LLD +
Sbjct: 234 RRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVL 293
Query: 440 ------------------LVAKVFDGGVVDDESYEIRIPADQ--------GIAGHVATTG 473
+ KV D + E ++ IP G+ +VA +G
Sbjct: 294 MGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKV-IPTPSADHWALASGLPSYVAESG 352
Query: 474 QILNIPDAYAHPLF--YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSK 531
I NI +A A +F G D +G+ +N+L PI N+ +E++GVA N+ +G F +
Sbjct: 353 FICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDE 412
Query: 532 FDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD--- 588
DE L + + + G S+ ++ Y K+N+ + R +A +M++YH+K DE +L
Sbjct: 413 QDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRAR 472
Query: 589 -GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMAILSMLQDMNFINN 631
G +P + F ++ E D + M ++ +
Sbjct: 473 LGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRK 532
Query: 632 YKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFI 691
++I L RF + KGYR YHNW H F+V+ + L +L +Y D+E FA+
Sbjct: 533 FQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVT 592
Query: 692 SCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSR 751
+ +CHD+DHRGTNN +Q+ S++ LA L+ S S++ERHH +L+ NI+ + +R
Sbjct: 593 AGLCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKFLLSEETLNIYQNLNR 650
Query: 752 KDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ-----------HHRLLL 800
+ ++ ++ LM I+ATDLA + + QK+ + + +K+ +++
Sbjct: 651 RQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVM 710
Query: 801 CLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDREK-AYIPEL 858
++MT+CDLS TK W+ K+A L+ EF+ QGDLE+ + +P+ MMDR K A +P+L
Sbjct: 711 AMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKL 770
Query: 859 QISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDE 918
Q+ F++ + +YK + +++R+ +NR+ W ++ ++ + +L+ +E
Sbjct: 771 QVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAK----VKALEEKEE 826
Query: 919 EYEVPDLDGTR------APINGCCSL 938
E V GT AP + C +
Sbjct: 827 EERVAAKKGTEICNGGPAPKSSTCCI 852
Score = 77.4 bits (189), Expect = 6e-14
Identities = 65/255 (25%), Positives = 120/255 (47%), Gaps = 29/255 (11%)
Query: 392 ECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN----ELVAKVFD- 446
E ALL++ +++ ++ V+ + ++ L A+ CS+F+ Q EL ++F
Sbjct: 55 ESTALLELVQDMQESINMERVVFK-VLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSV 113
Query: 447 --GGVVDD----ESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTR 500
V++D EI P D G+ GHVA T +++N+ D P F D+ T ++T+
Sbjct: 114 QPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTK 173
Query: 501 NILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEA 560
N+L PI N ++V+ V VNK+NGP+F+ DED+ + + + LY K+
Sbjct: 174 NMLATPIMN-GKDVVAVIMAVNKLNGPFFTSEDEDVFLKY-------LNFATLYLKIYHL 225
Query: 561 QYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRS-LPEDDTSMAI 619
Y + + ++ + +L I+ F YT R+ L + S+ +
Sbjct: 226 SYLHNCETRRGQVLLWSANKVFEEL--------TDIERQFHKAFYTVRAYLNCERYSVGL 277
Query: 620 LSMLQDMNFINNYKI 634
L M ++ F + + +
Sbjct: 278 LDMTKEKEFFDVWSV 292
>gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]
Length = 854
Score = 282 bits (721), Expect = 1e-75
Identities = 208/764 (27%), Positives = 360/764 (47%), Gaps = 99/764 (12%)
Query: 230 ILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSEDN--LQLSCKVIG---DKV 283
+L+L ++ + ++ + KVL+ L +A RC L + + N +L+ ++ D V
Sbjct: 59 LLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSV 118
Query: 284 LGE-------EVSFPLT-GCLGQVVEDKKSIQLKDLTS--EDVQQLQSMLGCELQAMLCV 333
L + E+ FPL G +G V + KK + ++D+ + + + ML
Sbjct: 119 LEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLAT 178
Query: 334 PVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCEC 393
P+++ VVA+ A NKL G FT EDE V ++ + L + CE
Sbjct: 179 PIMNGK--DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLK---IYHLSYLHNCET 233
Query: 394 ---QALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNE----------- 439
Q LL A +F L D+ + R N E SV LLD +
Sbjct: 234 RRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVL 293
Query: 440 ------------------LVAKVFDGGVVDDESYEIRIPADQ--------GIAGHVATTG 473
+ KV D + E ++ IP G+ +VA +G
Sbjct: 294 MGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKV-IPTPSADHWALASGLPSYVAESG 352
Query: 474 QILNIPDAYAHPLF--YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSK 531
I NI +A A +F G D +G+ +N+L PI N+ +E++GVA N+ +G F +
Sbjct: 353 FICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDE 412
Query: 532 FDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD--- 588
DE L + + + G S+ ++ Y K+N+ + R +A +M++YH+K DE +L
Sbjct: 413 QDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRAR 472
Query: 589 -GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMAILSMLQDMNFINN 631
G +P + F ++ E D + M ++ +
Sbjct: 473 LGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRK 532
Query: 632 YKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFI 691
++I L RF + KGYR YHNW H F+V+ + L +L +Y D+E FA+
Sbjct: 533 FQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVT 592
Query: 692 SCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSR 751
+ +CHD+DHRGTNN +Q+ S++ LA L+ S S++ERHH +L+ NI+ + +R
Sbjct: 593 AGLCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKFLLSEETLNIYQNLNR 650
Query: 752 KDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ-----------HHRLLL 800
+ ++ ++ LM I+ATDLA + + QK+ + + +K+ +++
Sbjct: 651 RQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVM 710
Query: 801 CLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDREK-AYIPEL 858
++MT+CDLS TK W+ K+A L+ EF+ QGDLE+ + +P+ MMDR K A +P+L
Sbjct: 711 AMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKL 770
Query: 859 QISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKF 902
Q+ F++ + +YK + +++R+ +NR+ W ++ ++
Sbjct: 771 QVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEY 814
Score = 77.4 bits (189), Expect = 6e-14
Identities = 65/255 (25%), Positives = 120/255 (47%), Gaps = 29/255 (11%)
Query: 392 ECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN----ELVAKVFD- 446
E ALL++ +++ ++ V+ + ++ L A+ CS+F+ Q EL ++F
Sbjct: 55 ESTALLELVQDMQESINMERVVFK-VLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSV 113
Query: 447 --GGVVDD----ESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTR 500
V++D EI P D G+ GHVA T +++N+ D P F D+ T ++T+
Sbjct: 114 QPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTK 173
Query: 501 NILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEA 560
N+L PI N ++V+ V VNK+NGP+F+ DED+ + + + LY K+
Sbjct: 174 NMLATPIMN-GKDVVAVIMAVNKLNGPFFTSEDEDVFLKY-------LNFATLYLKIYHL 225
Query: 561 QYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRS-LPEDDTSMAI 619
Y + + ++ + +L I+ F YT R+ L + S+ +
Sbjct: 226 SYLHNCETRRGQVLLWSANKVFEEL--------TDIERQFHKAFYTVRAYLNCERYSVGL 277
Query: 620 LSMLQDMNFINNYKI 634
L M ++ F + + +
Sbjct: 278 LDMTKEKEFFDVWSV 292
>gi|157364939 phosphodiesterase 6C [Homo sapiens]
Length = 858
Score = 259 bits (661), Expect = 1e-68
Identities = 195/745 (26%), Positives = 342/745 (45%), Gaps = 97/745 (13%)
Query: 248 KVLQYLQQETRASRCCLLLVSEDN--LQLSCKVIG--------DKVLG--EEVSFPLT-G 294
+ LQ L +A RC + L N +++ +++ D ++G +EV FPL G
Sbjct: 82 RALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIG 141
Query: 295 CLGQVVEDKKSIQLKDL--TSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNK 352
+G KK+ + D+ S + G + +L P++ +V+A+ A NK
Sbjct: 142 IVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIV--VGKEVLAVIMAVNK 199
Query: 353 LEGDLFTDEDEHVIQHCFHYTSTVLT---STLAFQKEQKLKCECQALLQVAKNLFTHLDD 409
+ F+ +DE V ++ S +L ++ + E + Q L+ A +F L D
Sbjct: 200 VNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESR---RSQILMWSANKVFEELTD 256
Query: 410 VSVLLQEIITEARNLSNAEICSVFLLDQNELVA------------------KVFDGGVVD 451
V + + R+ N E S+ LLD + K DG V+
Sbjct: 257 VERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVN 316
Query: 452 ---------DESYEIRI----PADQ-----GIAGHVATTGQILNIPDAYAHPLF--YRGV 491
EI++ PAD G+ +VA G I N+ +A A F +G
Sbjct: 317 FYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGP 376
Query: 492 DDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHS 551
D TG+ +N+L PI N+ ++++GVA N+ +G F + DE + + + G S+ ++
Sbjct: 377 VDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNT 436
Query: 552 LLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLH-------------DGIQPVAAIDS 598
Y K+N+ + R +A EM+M K + +E +L + Q VA +
Sbjct: 437 DTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKE 496
Query: 599 NFAS--------FTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGY 650
+ F ++ L E + + ++N + +K+ L R+ V+KGY
Sbjct: 497 DLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGY 556
Query: 651 RDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVA 710
R YHNW H F+V + L L Y D+E FA+ + CHD+DHRGTNN +Q+
Sbjct: 557 RAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMK 616
Query: 711 SKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDL 770
S S LA L+ S S++ERHH + +L NIF + +++ ++ ++ L I+ATDL
Sbjct: 617 STSPLARLHGS--SILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDL 674
Query: 771 AHHLRIFKDLQKMAE-----------VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTT 819
A + + QK+ + + Y + +++ ++MT+CDLS TK W+
Sbjct: 675 ALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQ 734
Query: 820 RKIAELIYKEFFSQGDLEK-AMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQDL 877
++A ++ EF+ QGDLE+ + +P+ MMDR K +P+LQ+ F++ + +YK
Sbjct: 735 SQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRF 794
Query: 878 FPKAAELYERVASNREHWTKVSHKF 902
+ + + +NR W ++ ++
Sbjct: 795 HKEITPMLSGLQNNRVEWKSLADEY 819
>gi|170650674 phosphodiesterase 6A [Homo sapiens]
Length = 860
Score = 256 bits (653), Expect = 9e-68
Identities = 188/717 (26%), Positives = 328/717 (45%), Gaps = 90/717 (12%)
Query: 264 LLLVSEDNLQLSCKVIGDKVLGEEVSFPLT-GCLGQVVEDKKSIQLKDLTSED---VQQL 319
L V +D + C V+ D +E+ FPL G +G V KK + + T ED +
Sbjct: 112 LFNVHKDAVLEDCLVMPD----QEIVFPLDMGIVGHVAHSKKIANVPN-TEEDEHFCDFV 166
Query: 320 QSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTS 379
+ + + +L P+++ VVA+ A NK++G FT DE ++ ++ + ++
Sbjct: 167 DILTEYKTKNILASPIMNGK--DVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMK- 223
Query: 380 TLAFQKEQKLKCEC---QALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLD 436
+ CE Q LL +F L D+ + + R N + SV LLD
Sbjct: 224 --VYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLD 281
Query: 437 QNELVA-----------------------------KVFDGGVVDDESYEI--RIPADQ-- 463
+ KV D + E ++ P D
Sbjct: 282 MTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWA 341
Query: 464 ---GIAGHVATTGQILNIPDAYAHPLFYRGVD--DSTGFRTRNILCFPIKNENQEVIGVA 518
G+ +VA G I NI +A A F + D +G+ +N+L PI N+ +E++GVA
Sbjct: 342 LVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVA 401
Query: 519 ELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVS 578
N+ +G F + DE L + + + G S+ + Y+ +N+ + R + +++ YH+K
Sbjct: 402 TFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCD 461
Query: 579 DDEYTKLLHD----GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMA 618
++E K+L G +P + A F ++ L E +
Sbjct: 462 NEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKC 521
Query: 619 ILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELT 678
+ M ++ ++ + I L RF + KGYR YHNW H F+V + L +L
Sbjct: 522 GIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLK 581
Query: 679 NYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAIL 738
Y D+E A+ + CHD+DHRGTNN +Q+ S++ LA L+ S S++ERHH +L
Sbjct: 582 RYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKTLL 639
Query: 739 NTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ---- 794
NIF + +R+ ++ + +M I+ATDLA + + QK+ + ++Q
Sbjct: 640 RDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQ 699
Query: 795 -------HHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPME 846
+++ ++MT+CDLS TK W+ ++A L+ EF+ QGDLE+ + P+
Sbjct: 700 YMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIP 759
Query: 847 MMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKF 902
MMDR KA +P+LQ+ F++ + +YK + + + + +NR+ W ++ ++
Sbjct: 760 MMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEY 816
Score = 67.8 bits (164), Expect = 5e-11
Identities = 81/302 (26%), Positives = 130/302 (43%), Gaps = 57/302 (18%)
Query: 352 KLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVS 411
KL DL ++ V +H S++ S + F L + Q LQ K +F + +
Sbjct: 31 KLISDLLGAKEAAVDFSNYHSPSSMEESEIIFD----LLRDFQENLQTEKCIFNVMKKLC 86
Query: 412 VLLQEIITEARNLSNAEICSVFLLDQN----ELVAKVFD---GGVVDD----ESYEIRIP 460
LLQ A+ S+F+ EL ++F+ V++D EI P
Sbjct: 87 FLLQ-----------ADRMSLFMYRTRNGIAELATRLFNVHKDAVLEDCLVMPDQEIVFP 135
Query: 461 ADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAEL 520
D GI GHVA + +I N+P+ F VD T ++T+NIL PI N ++V+ +
Sbjct: 136 LDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILASPIMN-GKDVVAIIMA 194
Query: 521 VNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDD 580
VNK++G F+K DE+ +L K +N A M +YH+ +
Sbjct: 195 VNKVDGSHFTKRDEE----------------ILLKYLNFANL------IMKVYHLSYLHN 232
Query: 581 EYTK----LLHDG---IQPVAAIDSNFASFTYTPRS-LPEDDTSMAILSMLQDMNFINNY 632
T+ LL G + + I+ F YT R+ L D S+ +L M + F + +
Sbjct: 233 CETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVW 292
Query: 633 KI 634
+
Sbjct: 293 PV 294
>gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]
Length = 575
Score = 249 bits (636), Expect = 8e-66
Identities = 142/474 (29%), Positives = 251/474 (52%), Gaps = 37/474 (7%)
Query: 464 GIAGHVATTGQILNIPDAYAHPLF--YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELV 521
G+ +VA +G I NI +A A +F G D +G+ +N+L PI N+ +E++GVA
Sbjct: 64 GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 123
Query: 522 NKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDE 581
N+ +G F + DE L + + + G S+ ++ Y K+N+ + R +A +M++YH+K DE
Sbjct: 124 NRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDE 183
Query: 582 YTKLLHD----GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMAILS 621
+L G +P + F ++ E D +
Sbjct: 184 IQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQ 243
Query: 622 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 681
M ++ + ++I L RF + KGYR YHNW H F+V+ + L +L +Y
Sbjct: 244 MYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYY 303
Query: 682 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 741
D+E FA+ + +CHD+DHRGTNN +Q+ S++ LA L+ S S++ERHH +L+
Sbjct: 304 TDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKFLLSEE 361
Query: 742 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ------- 794
NI+ + +R+ ++ ++ LM I+ATDLA + + QK+ + + +K+
Sbjct: 362 TLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLS 421
Query: 795 ----HHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMD 849
+++ ++MT+CDLS TK W+ K+A L+ EF+ QGDLE+ + +P+ MMD
Sbjct: 422 LETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMD 481
Query: 850 REK-AYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKF 902
R K A +P+LQ+ F++ + +YK + +++R+ +NR+ W ++ ++
Sbjct: 482 RNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEY 535
Score = 31.2 bits (69), Expect = 4.7
Identities = 14/67 (20%), Positives = 39/67 (58%), Gaps = 1/67 (1%)
Query: 324 GCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAF 383
G ++ +L +P++++ +++V +A +N+ +G F ++DE +++ + + +T +
Sbjct: 98 GWLIKNVLSMPIVNKK-EEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTY 156
Query: 384 QKEQKLK 390
K KL+
Sbjct: 157 DKMNKLE 163
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 156 bits (395), Expect = 7e-38
Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)
Query: 622 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 681
M D+ + ++ I+ TL R+ V YR+ P+HN+ H F V+ Y + L
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 130
Query: 682 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 741
+I L + +CHDLDH G NN++Q+ +++ LA Y ++ S +E HH A A IL
Sbjct: 131 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 189
Query: 742 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 801
CNIF + ++++ M +ILATD+A H I ++ E +D +N++H LL
Sbjct: 190 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 248
Query: 802 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 861
+L+ CD+S++ + + + + +E+F Q D EK+ G MDR+K QI
Sbjct: 249 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 308
Query: 862 FMEHIAMPIYKLLQDLFPKAAEL 884
F++ + +P+++ + LFP E+
Sbjct: 309 FIKFVLIPMFETVTKLFPMVEEI 331
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 156 bits (395), Expect = 7e-38
Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)
Query: 622 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 681
M D+ + ++ I+ TL R+ V YR+ P+HN+ H F V+ Y + L
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 130
Query: 682 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 741
+I L + +CHDLDH G NN++Q+ +++ LA Y ++ S +E HH A A IL
Sbjct: 131 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 189
Query: 742 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 801
CNIF + ++++ M +ILATD+A H I ++ E +D +N++H LL
Sbjct: 190 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 248
Query: 802 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 861
+L+ CD+S++ + + + + +E+F Q D EK+ G MDR+K QI
Sbjct: 249 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 308
Query: 862 FMEHIAMPIYKLLQDLFPKAAEL 884
F++ + +P+++ + LFP E+
Sbjct: 309 FIKFVLIPMFETVTKLFPMVEEI 331
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 156 bits (395), Expect = 7e-38
Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)
Query: 622 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 681
M D+ + ++ I+ TL R+ V YR+ P+HN+ H F V+ Y + L
Sbjct: 252 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 311
Query: 682 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 741
+I L + +CHDLDH G NN++Q+ +++ LA Y ++ S +E HH A A IL
Sbjct: 312 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 370
Query: 742 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 801
CNIF + ++++ M +ILATD+A H I ++ E +D +N++H LL
Sbjct: 371 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 429
Query: 802 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 861
+L+ CD+S++ + + + + +E+F Q D EK+ G MDR+K QI
Sbjct: 430 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 489
Query: 862 FMEHIAMPIYKLLQDLFPKAAEL 884
F++ + +P+++ + LFP E+
Sbjct: 490 FIKFVLIPMFETVTKLFPMVEEI 512
>gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]
Length = 552
Score = 156 bits (395), Expect = 7e-38
Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)
Query: 622 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 681
M D+ + ++ I+ TL R+ V YR+ P+HN+ H F V+ Y + L
Sbjct: 237 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 296
Query: 682 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 741
+I L + +CHDLDH G NN++Q+ +++ LA Y ++ S +E HH A A IL
Sbjct: 297 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 355
Query: 742 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 801
CNIF + ++++ M +ILATD+A H I ++ E +D +N++H LL
Sbjct: 356 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 414
Query: 802 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 861
+L+ CD+S++ + + + + +E+F Q D EK+ G MDR+K QI
Sbjct: 415 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 474
Query: 862 FMEHIAMPIYKLLQDLFPKAAEL 884
F++ + +P+++ + LFP E+
Sbjct: 475 FIKFVLIPMFETVTKLFPMVEEI 497
>gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens]
Length = 526
Score = 156 bits (395), Expect = 7e-38
Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)
Query: 622 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 681
M D+ + ++ I+ TL R+ V YR+ P+HN+ H F V+ Y + L
Sbjct: 211 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 270
Query: 682 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 741
+I L + +CHDLDH G NN++Q+ +++ LA Y ++ S +E HH A A IL
Sbjct: 271 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 329
Query: 742 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 801
CNIF + ++++ M +ILATD+A H I ++ E +D +N++H LL
Sbjct: 330 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 388
Query: 802 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 861
+L+ CD+S++ + + + + +E+F Q D EK+ G MDR+K QI
Sbjct: 389 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 448
Query: 862 FMEHIAMPIYKLLQDLFPKAAEL 884
F++ + +P+++ + LFP E+
Sbjct: 449 FIKFVLIPMFETVTKLFPMVEEI 471
>gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 156 bits (395), Expect = 7e-38
Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)
Query: 622 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 681
M D+ + ++ I+ TL R+ V YR+ P+HN+ H F V+ Y + L
Sbjct: 61 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 120
Query: 682 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 741
+I L + +CHDLDH G NN++Q+ +++ LA Y ++ S +E HH A A IL
Sbjct: 121 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 179
Query: 742 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 801
CNIF + ++++ M +ILATD+A H I ++ E +D +N++H LL
Sbjct: 180 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 238
Query: 802 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 861
+L+ CD+S++ + + + + +E+F Q D EK+ G MDR+K QI
Sbjct: 239 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 298
Query: 862 FMEHIAMPIYKLLQDLFPKAAEL 884
F++ + +P+++ + LFP E+
Sbjct: 299 FIKFVLIPMFETVTKLFPMVEEI 321
>gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 156 bits (395), Expect = 7e-38
Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)
Query: 622 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 681
M D+ + ++ I+ TL R+ V YR+ P+HN+ H F V+ Y + L
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 130
Query: 682 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 741
+I L + +CHDLDH G NN++Q+ +++ LA Y ++ S +E HH A A IL
Sbjct: 131 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 189
Query: 742 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 801
CNIF + ++++ M +ILATD+A H I ++ E +D +N++H LL
Sbjct: 190 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 248
Query: 802 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 861
+L+ CD+S++ + + + + +E+F Q D EK+ G MDR+K QI
Sbjct: 249 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 308
Query: 862 FMEHIAMPIYKLLQDLFPKAAEL 884
F++ + +P+++ + LFP E+
Sbjct: 309 FIKFVLIPMFETVTKLFPMVEEI 331
>gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens]
Length = 491
Score = 156 bits (395), Expect = 7e-38
Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)
Query: 622 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 681
M D+ + ++ I+ TL R+ V YR+ P+HN+ H F V+ Y + L
Sbjct: 176 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 235
Query: 682 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 741
+I L + +CHDLDH G NN++Q+ +++ LA Y ++ S +E HH A A IL
Sbjct: 236 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 294
Query: 742 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 801
CNIF + ++++ M +ILATD+A H I ++ E +D +N++H LL
Sbjct: 295 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 353
Query: 802 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 861
+L+ CD+S++ + + + + +E+F Q D EK+ G MDR+K QI
Sbjct: 354 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 413
Query: 862 FMEHIAMPIYKLLQDLFPKAAEL 884
F++ + +P+++ + LFP E+
Sbjct: 414 FIKFVLIPMFETVTKLFPMVEEI 436
>gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens]
Length = 459
Score = 156 bits (395), Expect = 7e-38
Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)
Query: 622 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 681
M D+ + ++ I+ TL R+ V YR+ P+HN+ H F V+ Y + L
Sbjct: 144 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 203
Query: 682 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 741
+I L + +CHDLDH G NN++Q+ +++ LA Y ++ S +E HH A A IL
Sbjct: 204 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 262
Query: 742 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 801
CNIF + ++++ M +ILATD+A H I ++ E +D +N++H LL
Sbjct: 263 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 321
Query: 802 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 861
+L+ CD+S++ + + + + +E+F Q D EK+ G MDR+K QI
Sbjct: 322 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 381
Query: 862 FMEHIAMPIYKLLQDLFPKAAEL 884
F++ + +P+++ + LFP E+
Sbjct: 382 FIKFVLIPMFETVTKLFPMVEEI 404
>gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 156 bits (395), Expect = 7e-38
Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)
Query: 622 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 681
M D+ + ++ I+ TL R+ V YR+ P+HN+ H F V+ Y + L
Sbjct: 61 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 120
Query: 682 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 741
+I L + +CHDLDH G NN++Q+ +++ LA Y ++ S +E HH A A IL
Sbjct: 121 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 179
Query: 742 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 801
CNIF + ++++ M +ILATD+A H I ++ E +D +N++H LL
Sbjct: 180 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 238
Query: 802 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 861
+L+ CD+S++ + + + + +E+F Q D EK+ G MDR+K QI
Sbjct: 239 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 298
Query: 862 FMEHIAMPIYKLLQDLFPKAAEL 884
F++ + +P+++ + LFP E+
Sbjct: 299 FIKFVLIPMFETVTKLFPMVEEI 321
>gi|48762734 phosphodiesterase 9A isoform i [Homo sapiens]
Length = 433
Score = 156 bits (395), Expect = 7e-38
Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)
Query: 622 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 681
M D+ + ++ I+ TL R+ V YR+ P+HN+ H F V+ Y + L
Sbjct: 118 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 177
Query: 682 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 741
+I L + +CHDLDH G NN++Q+ +++ LA Y ++ S +E HH A A IL
Sbjct: 178 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 236
Query: 742 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 801
CNIF + ++++ M +ILATD+A H I ++ E +D +N++H LL
Sbjct: 237 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 295
Query: 802 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 861
+L+ CD+S++ + + + + +E+F Q D EK+ G MDR+K QI
Sbjct: 296 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 355
Query: 862 FMEHIAMPIYKLLQDLFPKAAEL 884
F++ + +P+++ + LFP E+
Sbjct: 356 FIKFVLIPMFETVTKLFPMVEEI 378
>gi|48762732 phosphodiesterase 9A isoform h [Homo sapiens]
Length = 507
Score = 156 bits (395), Expect = 7e-38
Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)
Query: 622 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 681
M D+ + ++ I+ TL R+ V YR+ P+HN+ H F V+ Y + L
Sbjct: 192 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 251
Query: 682 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 741
+I L + +CHDLDH G NN++Q+ +++ LA Y ++ S +E HH A A IL
Sbjct: 252 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 310
Query: 742 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 801
CNIF + ++++ M +ILATD+A H I ++ E +D +N++H LL
Sbjct: 311 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 369
Query: 802 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 861
+L+ CD+S++ + + + + +E+F Q D EK+ G MDR+K QI
Sbjct: 370 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 429
Query: 862 FMEHIAMPIYKLLQDLFPKAAEL 884
F++ + +P+++ + LFP E+
Sbjct: 430 FIKFVLIPMFETVTKLFPMVEEI 452
>gi|48762730 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 156 bits (395), Expect = 7e-38
Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)
Query: 622 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 681
M D+ + ++ I+ TL R+ V YR+ P+HN+ H F V+ Y + L
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 130
Query: 682 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 741
+I L + +CHDLDH G NN++Q+ +++ LA Y ++ S +E HH A A IL
Sbjct: 131 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 189
Query: 742 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 801
CNIF + ++++ M +ILATD+A H I ++ E +D +N++H LL
Sbjct: 190 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 248
Query: 802 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 861
+L+ CD+S++ + + + + +E+F Q D EK+ G MDR+K QI
Sbjct: 249 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 308
Query: 862 FMEHIAMPIYKLLQDLFPKAAEL 884
F++ + +P+++ + LFP E+
Sbjct: 309 FIKFVLIPMFETVTKLFPMVEEI 331
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,703,191
Number of Sequences: 37866
Number of extensions: 1607919
Number of successful extensions: 7949
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 7521
Number of HSP's gapped (non-prelim): 243
length of query: 941
length of database: 18,247,518
effective HSP length: 112
effective length of query: 829
effective length of database: 14,006,526
effective search space: 11611410054
effective search space used: 11611410054
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.