Search of human proteins with 4504653

Search of human proteins with 4504653

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4504653 interleukin 18 proprotein [Homo sapiens]
         (193 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4504653 interleukin 18 proprotein [Homo sapiens]                   391   e-109
gi|121583542 mitogen-activated protein kinase kinase kinase 15 [...    33   0.15 
gi|226491199 coiled-coil domain containing 38 [Homo sapiens]           32   0.26 
gi|40254931 hypothetical protein LOC55732 [Homo sapiens]               31   0.57 
gi|167860126 serine (or cysteine) proteinase inhibitor, clade B ...    29   2.2  
gi|56676397 ankyrin repeat domain 11 [Homo sapiens]                    29   2.2  
gi|23510348 TRAF and TNF receptor-associated protein [Homo sapiens]    28   3.7  
gi|15529996 son of sevenless homolog 1 [Homo sapiens]                  28   6.3  
gi|151301080 recombination activating gene 2 [Homo sapiens]            27   8.3  
gi|73390140 LIM domain kinase 2 isoform 1 [Homo sapiens]               27   8.3  
gi|8051618 LIM domain kinase 2 isoform 2b [Homo sapiens]               27   8.3  
gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens]               27   8.3  
gi|117190519 sialidase 3 [Homo sapiens]                                27   8.3  
gi|7705716 nitric oxide synthase interacting protein [Homo sapiens]    27   8.3  

>gi|4504653 interleukin 18 proprotein [Homo sapiens]
          Length = 193

 Score =  391 bits (1004), Expect = e-109
 Identities = 193/193 (100%), Positives = 193/193 (100%)

Query: 1   MAAEPVEDNCINFVAMKFIDNTLYFIAEDDENLESDYFGKLESKLSVIRNLNDQVLFIDQ 60
           MAAEPVEDNCINFVAMKFIDNTLYFIAEDDENLESDYFGKLESKLSVIRNLNDQVLFIDQ
Sbjct: 1   MAAEPVEDNCINFVAMKFIDNTLYFIAEDDENLESDYFGKLESKLSVIRNLNDQVLFIDQ 60

Query: 61  GNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFK 120
           GNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFK
Sbjct: 61  GNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFK 120

Query: 121 EMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDEL 180
           EMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDEL
Sbjct: 121 EMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDEL 180

Query: 181 GDRSIMFTVQNED 193
           GDRSIMFTVQNED
Sbjct: 181 GDRSIMFTVQNED 193


>gi|121583542 mitogen-activated protein kinase kinase kinase 15
           [Homo sapiens]
          Length = 788

 Score = 33.1 bits (74), Expect = 0.15
 Identities = 33/112 (29%), Positives = 57/112 (50%), Gaps = 16/112 (14%)

Query: 88  YKDSQ-PRGMAVTISVKCEKISTLSCENKIISFKEMNPPDNIKDTKSDIIFFQRSVP--- 143
           +K S+ PRG+ + +  + E ++T S E+  +S      PD+  D + D +F +   P   
Sbjct: 396 FKPSEGPRGVVLALPTQGEPMATSSSEHGSVS------PDS--DAQPDALFERTRAPRHH 447

Query: 144 -GHDNKMQFESSSYEGYFLACEKE-RDLFKLILKKEDELGDRSIMFTVQNED 193
            GH   +  ESS+ E   LA   E RD    +L+K+ E   R+I++ +  E+
Sbjct: 448 LGHLLSVPDESSALEDRGLASSPEDRDQGLFLLRKDSE--RRAILYKILWEE 497


>gi|226491199 coiled-coil domain containing 38 [Homo sapiens]
          Length = 563

 Score = 32.3 bits (72), Expect = 0.26
 Identities = 26/109 (23%), Positives = 57/109 (52%), Gaps = 6/109 (5%)

Query: 20  DNTLYFIAEDDENLESD---YFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRD 76
           +++L F+ +D+ +++ +   YF + E  L V+R L +Q L + Q ++ + E++ + + R+
Sbjct: 315 EDSLEFLLDDEMDVDLEPALYFKEPEELLQVLRELEEQNLTLFQYSQDVDENLEEVNKRE 374

Query: 77  NA--PRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFKEMN 123
                +T   I    + +    A  +  + EK + L  ++K+ SF E N
Sbjct: 375 KVIQDKTNSNIEFLLEQEKMLKANCVREE-EKAAELQLKSKLFSFGEFN 422


>gi|40254931 hypothetical protein LOC55732 [Homo sapiens]
          Length = 853

 Score = 31.2 bits (69), Expect = 0.57
 Identities = 22/66 (33%), Positives = 32/66 (48%), Gaps = 1/66 (1%)

Query: 18  FIDNTLYFIAEDDENLESDYFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDN 77
           F  NT  FI +     +S    +L+ K  +I +L + +LF       L E MT SD +DN
Sbjct: 178 FHANTWKFIIKQSLKHQSIIKSQLKHK-DIITSLCEDILFSFHSCLQLAEQMTQSDAQDN 236

Query: 78  APRTIF 83
           A   +F
Sbjct: 237 ADYRLF 242


>gi|167860126 serine (or cysteine) proteinase inhibitor, clade B
           (ovalbumin), member 5 [Homo sapiens]
          Length = 375

 Score = 29.3 bits (64), Expect = 2.2
 Identities = 19/71 (26%), Positives = 31/71 (43%)

Query: 11  INFVAMKFIDNTLYFIAEDDENLESDYFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMT 70
           ++F  +K +      +  D   L S Y  KL  +L V ++LN    FI    RP  +++ 
Sbjct: 58  LHFENVKDVPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELE 117

Query: 71  DSDCRDNAPRT 81
             D +D    T
Sbjct: 118 TVDFKDKLEET 128


>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
          Length = 2663

 Score = 29.3 bits (64), Expect = 2.2
 Identities = 20/55 (36%), Positives = 24/55 (43%)

Query: 103 KCEKISTLSCENKIISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYE 157
           K EK+S +  E K   FK+      IKDT  DI    R      NK + E S  E
Sbjct: 696 KEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKE 750


>gi|23510348 TRAF and TNF receptor-associated protein [Homo sapiens]
          Length = 362

 Score = 28.5 bits (62), Expect = 3.7
 Identities = 42/178 (23%), Positives = 76/178 (42%), Gaps = 30/178 (16%)

Query: 10  CINFVAMKFIDNTLY--FIAEDDENLE---SDYFGKLESKLSVIRN---LNDQVLFIDQG 61
           C+ F ++   D  +   F+AE+D  +E   + YF     + ++ R    +++   ++D  
Sbjct: 29  CVEFASVASCDAAVAQCFLAENDWEMERALNSYFEPPVEESALERRPETISEPKTYVDLT 88

Query: 62  NRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFKE 121
           N    E+ TDS        T   IS  +D+Q    ++  S+    I  L   N  +S + 
Sbjct: 89  N----EETTDS--------TTSKISPSEDTQQENGSM-FSLITWNIDGLDLNN--LSERA 133

Query: 122 MNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSY-------EGYFLACEKERDLFKL 172
                 +     D+IF Q  +P + + ++  SS+Y       EGYF A   ++   KL
Sbjct: 134 RGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKL 191


>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
          Length = 1333

 Score = 27.7 bits (60), Expect = 6.3
 Identities = 18/59 (30%), Positives = 30/59 (50%), Gaps = 5/59 (8%)

Query: 18  FIDNTLYFIAEDDENLESDYFGKLESKLSVIRNLNDQVLFIDQGN-RPL----FEDMTD 71
           F+ N+  F A D EN+ S      E  + ++ ++ D V   D+G+  PL    FED+ +
Sbjct: 230 FVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAE 288


>gi|151301080 recombination activating gene 2 [Homo sapiens]
          Length = 527

 Score = 27.3 bits (59), Expect = 8.3
 Identities = 21/66 (31%), Positives = 30/66 (45%), Gaps = 11/66 (16%)

Query: 110 LSCENKIISFKEMNPPDNIKDTKSDIIFFQRS---------VPGHDNKMQFESSSYEGYF 160
           +S E+  I  +EM  PD   D K   I+F  +         +PG DNK Q  S  +  Y 
Sbjct: 290 ISLEDNKIEIREMETPDWTPDIKHSKIWFGSNMGNGTVFLGIPG-DNK-QVVSEGFYFYM 347

Query: 161 LACEKE 166
           L C ++
Sbjct: 348 LKCAED 353


>gi|73390140 LIM domain kinase 2 isoform 1 [Homo sapiens]
          Length = 686

 Score = 27.3 bits (59), Expect = 8.3
 Identities = 15/61 (24%), Positives = 31/61 (50%), Gaps = 7/61 (11%)

Query: 64  PLFEDMTDSDCRDNAPRTIFIISMYKDSQ-PRGMAVTISVKCEKISTLSCENKIISFKEM 122
           P+FE ++    ++  P ++ +ISM   ++  RG +V++   C   +T       +  KE+
Sbjct: 111 PMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYAT------TVQVKEV 164

Query: 123 N 123
           N
Sbjct: 165 N 165


>gi|8051618 LIM domain kinase 2 isoform 2b [Homo sapiens]
          Length = 617

 Score = 27.3 bits (59), Expect = 8.3
 Identities = 15/61 (24%), Positives = 31/61 (50%), Gaps = 7/61 (11%)

Query: 64  PLFEDMTDSDCRDNAPRTIFIISMYKDSQ-PRGMAVTISVKCEKISTLSCENKIISFKEM 122
           P+FE ++    ++  P ++ +ISM   ++  RG +V++   C   +T       +  KE+
Sbjct: 111 PMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYAT------TVQVKEV 164

Query: 123 N 123
           N
Sbjct: 165 N 165


>gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens]
          Length = 638

 Score = 27.3 bits (59), Expect = 8.3
 Identities = 15/61 (24%), Positives = 31/61 (50%), Gaps = 7/61 (11%)

Query: 64  PLFEDMTDSDCRDNAPRTIFIISMYKDSQ-PRGMAVTISVKCEKISTLSCENKIISFKEM 122
           P+FE ++    ++  P ++ +ISM   ++  RG +V++   C   +T       +  KE+
Sbjct: 132 PMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYAT------TVQVKEV 185

Query: 123 N 123
           N
Sbjct: 186 N 186


>gi|117190519 sialidase 3 [Homo sapiens]
          Length = 461

 Score = 27.3 bits (59), Expect = 8.3
 Identities = 12/45 (26%), Positives = 25/45 (55%), Gaps = 1/45 (2%)

Query: 112 CENKIISFKEMNPPDNIKDTKS-DIIFFQRSVPGHDNKMQFESSS 155
           C+  ++SF+ +  P   +D+ S D    Q+S PG   +++ E+ +
Sbjct: 312 CQGSVVSFRPLEIPHRCQDSSSKDAPTIQQSSPGSSLRLEEEAGT 356


>gi|7705716 nitric oxide synthase interacting protein [Homo sapiens]
          Length = 301

 Score = 27.3 bits (59), Expect = 8.3
 Identities = 20/75 (26%), Positives = 31/75 (41%), Gaps = 3/75 (4%)

Query: 83  FIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFKEMNPPDNIKDTKSDIIFFQR-- 140
           ++ ++ +DS        +      + TL C  K+I    ++P    K T  DII  QR  
Sbjct: 221 YVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVTGDKLTDRDIIVLQRGG 280

Query: 141 -SVPGHDNKMQFESS 154
               G   K+Q E S
Sbjct: 281 TGFAGSGVKLQAEKS 295


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,082,899
Number of Sequences: 37866
Number of extensions: 287252
Number of successful extensions: 603
Number of sequences better than 10.0: 14
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 598
Number of HSP's gapped (non-prelim): 15
length of query: 193
length of database: 18,247,518
effective HSP length: 97
effective length of query: 96
effective length of database: 14,574,516
effective search space: 1399153536
effective search space used: 1399153536
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.