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Search of human proteins with 4504211
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
(732 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens] 1470 0.0
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 620 e-177
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 620 e-177
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom... 620 e-177
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 620 e-177
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho... 570 e-162
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho... 535 e-152
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens] 340 3e-93
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens] 181 2e-45
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 181 2e-45
gi|134152694 guanylate cyclase 2F [Homo sapiens] 167 2e-41
gi|222080083 guanylate cyclase 2C [Homo sapiens] 164 2e-40
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom... 164 2e-40
gi|194595480 guanylate cyclase 1, soluble, alpha 3 isoform C [Ho... 156 6e-38
gi|31083193 adenylate cyclase 1 [Homo sapiens] 117 4e-26
gi|115387102 adenylate cyclase 2 [Homo sapiens] 116 8e-26
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens] 114 2e-25
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 114 2e-25
gi|148536830 adenylate cyclase 3 [Homo sapiens] 113 5e-25
gi|24497587 adenylate cyclase 4 [Homo sapiens] 113 5e-25
gi|4557255 adenylate cyclase 7 [Homo sapiens] 112 1e-24
gi|34486092 adenylate cyclase 5 [Homo sapiens] 110 4e-24
gi|4557257 adenylate cyclase 8 [Homo sapiens] 103 6e-22
gi|50959205 adenylate cyclase 9 [Homo sapiens] 98 2e-20
gi|154146199 sal-like 3 [Homo sapiens] 44 7e-04
gi|15967156 SCAN domain containing protein 1 [Homo sapiens] 39 0.017
gi|7706089 SCAN domain containing protein 1 [Homo sapiens] 39 0.017
gi|5031759 homeobox A11 [Homo sapiens] 39 0.022
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens] 39 0.022
gi|118344456 UTP18, small subunit processome component [Homo sap... 37 0.050
>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
Length = 732
Score = 1470 bits (3806), Expect = 0.0
Identities = 732/732 (100%), Positives = 732/732 (100%)
Query: 1 MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPA 60
MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPA
Sbjct: 1 MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPA 60
Query: 61 PTPAASAAAAAATAGARRVQRRRRVNLDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQV 120
PTPAASAAAAAATAGARRVQRRRRVNLDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQV
Sbjct: 61 PTPAASAAAAAATAGARRVQRRRRVNLDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQV 120
Query: 121 IGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTANILGLKFEEIQKRFGEEFFNI 180
IGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTANILGLKFEEIQKRFGEEFFNI
Sbjct: 121 IGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTANILGLKFEEIQKRFGEEFFNI 180
Query: 181 CFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYF 240
CFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYF
Sbjct: 181 CFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYF 240
Query: 241 HPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKLCSDVSNPGNCSCLTFLIKECENTN 300
HPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKLCSDVSNPGNCSCLTFLIKECENTN
Sbjct: 241 HPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKLCSDVSNPGNCSCLTFLIKECENTN 300
Query: 301 IMKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKF 360
IMKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKF
Sbjct: 301 IMKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKF 360
Query: 361 EDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSIL 420
EDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSIL
Sbjct: 361 EDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSIL 420
Query: 421 FLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTH 480
FLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTH
Sbjct: 421 FLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTH 480
Query: 481 QALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPM 540
QALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPM
Sbjct: 481 QALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPM 540
Query: 541 QVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELS 600
QVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELS
Sbjct: 541 QVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELS 600
Query: 601 EEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSP 660
EEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSP
Sbjct: 601 EEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSP 660
Query: 661 TTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSY 720
TTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSY
Sbjct: 661 TTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSY 720
Query: 721 NIGTMFLRETSL 732
NIGTMFLRETSL
Sbjct: 721 NIGTMFLRETSL 732
>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 620 bits (1598), Expect = e-177
Identities = 345/700 (49%), Positives = 452/700 (64%), Gaps = 36/700 (5%)
Query: 27 GECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVN 86
GECP S L + P E + ++ + A P + +R R RV
Sbjct: 13 GECPFSLLA--PGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVY 70
Query: 87 LDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKE 146
L +L ESI +L P + + L+RTL +H++ +++ K+
Sbjct: 71 LHTLAESICKLIFPEFERLNVALQRTLA--KHKI---KESRKSL---------------- 109
Query: 147 EIEDVSGILQCTANILGLKFEEIQKRFGEEFFNICFHENERVLRAVGGTLQDFFNGFDAL 206
E ED + A G+ E I++ GEE F IC+ E+E +L VGGTL+DF N F L
Sbjct: 110 EREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTL 169
Query: 207 LE---HIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYR 263
L+ H + + GK+ LE S LC + + L ++YF P + G+IKAA +Y
Sbjct: 170 LKQSSHCQEA-GKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYE 228
Query: 264 LDVEVEQVANEKLCSDVSNPGNCSCLTFLIK-ECENTNIMKNLPQGTSQVPADLRISINT 322
+VEV + +D S N L + + + ++ + PQ + +P L
Sbjct: 229 TEVEVSLMP-PCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSL------ 281
Query: 323 FCRAFPFHLMFDPSMSVLQLGEGLRKQL-RCDTHKVLKFEDCFEIVSPKVNATFERVLLR 381
FC+ FPFH MFD M++LQ G G+R+ + R D FE+ FEI++PK+N TF ++
Sbjct: 282 FCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTM 341
Query: 382 LSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLS 441
L+ FV+R + + + +VM++KGQMI++ ES++ILFLGSPCVD+L++ GRGL+LS
Sbjct: 342 LNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLS 401
Query: 442 DIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGD 501
DIPIH+A RDV+L+GEQA+AQDGLKKR+ KLKATLE+ HQALEEEKKKTVDLL SIFP +
Sbjct: 402 DIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCE 461
Query: 502 VAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLD 561
VAQQLWQGQ VQA+KF +VTMLFSDIVGFTAIC+QC+P+QVI+MLN LYTRFD QCG LD
Sbjct: 462 VAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELD 521
Query: 562 IYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGS 621
+YKVETIGDAYCVA GLH++S HA IALMALKMMELS+EV++P G PI+MRIG+HSGS
Sbjct: 522 VYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGS 581
Query: 622 VLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREE 681
V AGVVGV+MPRYCLFGNNVTLA+KFES S PR+INVSPTTY+LLK F F PRSREE
Sbjct: 582 VFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREE 641
Query: 682 LPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSYN 721
LP NFP EIPGIC+FL+ KP ++ + N
Sbjct: 642 LPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNAN 681
>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 620 bits (1598), Expect = e-177
Identities = 345/700 (49%), Positives = 452/700 (64%), Gaps = 36/700 (5%)
Query: 27 GECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVN 86
GECP S L + P E + ++ + A P + +R R RV
Sbjct: 13 GECPFSLLA--PGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVY 70
Query: 87 LDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKE 146
L +L ESI +L P + + L+RTL +H++ +++ K+
Sbjct: 71 LHTLAESICKLIFPEFERLNVALQRTLA--KHKI---KESRKSL---------------- 109
Query: 147 EIEDVSGILQCTANILGLKFEEIQKRFGEEFFNICFHENERVLRAVGGTLQDFFNGFDAL 206
E ED + A G+ E I++ GEE F IC+ E+E +L VGGTL+DF N F L
Sbjct: 110 EREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTL 169
Query: 207 LE---HIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYR 263
L+ H + + GK+ LE S LC + + L ++YF P + G+IKAA +Y
Sbjct: 170 LKQSSHCQEA-GKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYE 228
Query: 264 LDVEVEQVANEKLCSDVSNPGNCSCLTFLIK-ECENTNIMKNLPQGTSQVPADLRISINT 322
+VEV + +D S N L + + + ++ + PQ + +P L
Sbjct: 229 TEVEVSLMP-PCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSL------ 281
Query: 323 FCRAFPFHLMFDPSMSVLQLGEGLRKQL-RCDTHKVLKFEDCFEIVSPKVNATFERVLLR 381
FC+ FPFH MFD M++LQ G G+R+ + R D FE+ FEI++PK+N TF ++
Sbjct: 282 FCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTM 341
Query: 382 LSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLS 441
L+ FV+R + + + +VM++KGQMI++ ES++ILFLGSPCVD+L++ GRGL+LS
Sbjct: 342 LNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLS 401
Query: 442 DIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGD 501
DIPIH+A RDV+L+GEQA+AQDGLKKR+ KLKATLE+ HQALEEEKKKTVDLL SIFP +
Sbjct: 402 DIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCE 461
Query: 502 VAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLD 561
VAQQLWQGQ VQA+KF +VTMLFSDIVGFTAIC+QC+P+QVI+MLN LYTRFD QCG LD
Sbjct: 462 VAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELD 521
Query: 562 IYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGS 621
+YKVETIGDAYCVA GLH++S HA IALMALKMMELS+EV++P G PI+MRIG+HSGS
Sbjct: 522 VYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGS 581
Query: 622 VLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREE 681
V AGVVGV+MPRYCLFGNNVTLA+KFES S PR+INVSPTTY+LLK F F PRSREE
Sbjct: 582 VFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREE 641
Query: 682 LPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSYN 721
LP NFP EIPGIC+FL+ KP ++ + N
Sbjct: 642 LPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNAN 681
>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 620 bits (1598), Expect = e-177
Identities = 345/700 (49%), Positives = 452/700 (64%), Gaps = 36/700 (5%)
Query: 27 GECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVN 86
GECP S L + P E + ++ + A P + +R R RV
Sbjct: 13 GECPFSLLA--PGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVY 70
Query: 87 LDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKE 146
L +L ESI +L P + + L+RTL +H++ +++ K+
Sbjct: 71 LHTLAESICKLIFPEFERLNVALQRTLA--KHKI---KESRKSL---------------- 109
Query: 147 EIEDVSGILQCTANILGLKFEEIQKRFGEEFFNICFHENERVLRAVGGTLQDFFNGFDAL 206
E ED + A G+ E I++ GEE F IC+ E+E +L VGGTL+DF N F L
Sbjct: 110 EREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTL 169
Query: 207 LE---HIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYR 263
L+ H + + GK+ LE S LC + + L ++YF P + G+IKAA +Y
Sbjct: 170 LKQSSHCQEA-GKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYE 228
Query: 264 LDVEVEQVANEKLCSDVSNPGNCSCLTFLIK-ECENTNIMKNLPQGTSQVPADLRISINT 322
+VEV + +D S N L + + + ++ + PQ + +P L
Sbjct: 229 TEVEVSLMP-PCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSL------ 281
Query: 323 FCRAFPFHLMFDPSMSVLQLGEGLRKQL-RCDTHKVLKFEDCFEIVSPKVNATFERVLLR 381
FC+ FPFH MFD M++LQ G G+R+ + R D FE+ FEI++PK+N TF ++
Sbjct: 282 FCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTM 341
Query: 382 LSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLS 441
L+ FV+R + + + +VM++KGQMI++ ES++ILFLGSPCVD+L++ GRGL+LS
Sbjct: 342 LNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLS 401
Query: 442 DIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGD 501
DIPIH+A RDV+L+GEQA+AQDGLKKR+ KLKATLE+ HQALEEEKKKTVDLL SIFP +
Sbjct: 402 DIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCE 461
Query: 502 VAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLD 561
VAQQLWQGQ VQA+KF +VTMLFSDIVGFTAIC+QC+P+QVI+MLN LYTRFD QCG LD
Sbjct: 462 VAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELD 521
Query: 562 IYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGS 621
+YKVETIGDAYCVA GLH++S HA IALMALKMMELS+EV++P G PI+MRIG+HSGS
Sbjct: 522 VYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGS 581
Query: 622 VLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREE 681
V AGVVGV+MPRYCLFGNNVTLA+KFES S PR+INVSPTTY+LLK F F PRSREE
Sbjct: 582 VFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREE 641
Query: 682 LPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSYN 721
LP NFP EIPGIC+FL+ KP ++ + N
Sbjct: 642 LPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNAN 681
>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 620 bits (1598), Expect = e-177
Identities = 345/700 (49%), Positives = 452/700 (64%), Gaps = 36/700 (5%)
Query: 27 GECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVN 86
GECP S L + P E + ++ + A P + +R R RV
Sbjct: 13 GECPFSLLA--PGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVY 70
Query: 87 LDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKE 146
L +L ESI +L P + + L+RTL +H++ +++ K+
Sbjct: 71 LHTLAESICKLIFPEFERLNVALQRTLA--KHKI---KESRKSL---------------- 109
Query: 147 EIEDVSGILQCTANILGLKFEEIQKRFGEEFFNICFHENERVLRAVGGTLQDFFNGFDAL 206
E ED + A G+ E I++ GEE F IC+ E+E +L VGGTL+DF N F L
Sbjct: 110 EREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTL 169
Query: 207 LE---HIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYR 263
L+ H + + GK+ LE S LC + + L ++YF P + G+IKAA +Y
Sbjct: 170 LKQSSHCQEA-GKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYE 228
Query: 264 LDVEVEQVANEKLCSDVSNPGNCSCLTFLIK-ECENTNIMKNLPQGTSQVPADLRISINT 322
+VEV + +D S N L + + + ++ + PQ + +P L
Sbjct: 229 TEVEVSLMP-PCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSL------ 281
Query: 323 FCRAFPFHLMFDPSMSVLQLGEGLRKQL-RCDTHKVLKFEDCFEIVSPKVNATFERVLLR 381
FC+ FPFH MFD M++LQ G G+R+ + R D FE+ FEI++PK+N TF ++
Sbjct: 282 FCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTM 341
Query: 382 LSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLS 441
L+ FV+R + + + +VM++KGQMI++ ES++ILFLGSPCVD+L++ GRGL+LS
Sbjct: 342 LNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLS 401
Query: 442 DIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGD 501
DIPIH+A RDV+L+GEQA+AQDGLKKR+ KLKATLE+ HQALEEEKKKTVDLL SIFP +
Sbjct: 402 DIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCE 461
Query: 502 VAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLD 561
VAQQLWQGQ VQA+KF +VTMLFSDIVGFTAIC+QC+P+QVI+MLN LYTRFD QCG LD
Sbjct: 462 VAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELD 521
Query: 562 IYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGS 621
+YKVETIGDAYCVA GLH++S HA IALMALKMMELS+EV++P G PI+MRIG+HSGS
Sbjct: 522 VYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGS 581
Query: 622 VLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREE 681
V AGVVGV+MPRYCLFGNNVTLA+KFES S PR+INVSPTTY+LLK F F PRSREE
Sbjct: 582 VFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREE 641
Query: 682 LPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSYN 721
LP NFP EIPGIC+FL+ KP ++ + N
Sbjct: 642 LPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNAN 681
>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
sapiens]
Length = 624
Score = 570 bits (1469), Expect = e-162
Identities = 318/643 (49%), Positives = 420/643 (65%), Gaps = 36/643 (5%)
Query: 27 GECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVN 86
GECP S L + P E + ++ + A P + +R R RV
Sbjct: 13 GECPFSLLA--PGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVY 70
Query: 87 LDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKE 146
L +L ESI +L P + + L+RTL +H++ +++ K+
Sbjct: 71 LHTLAESICKLIFPEFERLNVALQRTLA--KHKI---KESRKSL---------------- 109
Query: 147 EIEDVSGILQCTANILGLKFEEIQKRFGEEFFNICFHENERVLRAVGGTLQDFFNGFDAL 206
E ED + A G+ E I++ GEE F IC+ E+E +L VGGTL+DF N F L
Sbjct: 110 EREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTL 169
Query: 207 LE---HIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYR 263
L+ H + + GK+ LE S LC + + L ++YF P + G+IKAA +Y
Sbjct: 170 LKQSSHCQEA-GKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYE 228
Query: 264 LDVEVEQVANEKLCSDVSNPGNCSCLTFLIK-ECENTNIMKNLPQGTSQVPADLRISINT 322
+VEV + +D S N L + + + ++ + PQ + +P L
Sbjct: 229 TEVEVSLMP-PCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSL------ 281
Query: 323 FCRAFPFHLMFDPSMSVLQLGEGLRKQL-RCDTHKVLKFEDCFEIVSPKVNATFERVLLR 381
FC+ FPFH MFD M++LQ G G+R+ + R D FE+ FEI++PK+N TF ++
Sbjct: 282 FCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTM 341
Query: 382 LSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLS 441
L+ FV+R + + + +VM++KGQMI++ ES++ILFLGSPCVD+L++ GRGL+LS
Sbjct: 342 LNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLS 401
Query: 442 DIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGD 501
DIPIH+A RDV+L+GEQA+AQDGLKKR+ KLKATLE+ HQALEEEKKKTVDLL SIFP +
Sbjct: 402 DIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCE 461
Query: 502 VAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLD 561
VAQQLWQGQ VQA+KF +VTMLFSDIVGFTAIC+QC+P+QVI+MLN LYTRFD QCG LD
Sbjct: 462 VAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELD 521
Query: 562 IYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGS 621
+YKVETIGDAYCVA GLH++S HA IALMALKMMELS+EV++P G PI+MRIG+HSGS
Sbjct: 522 VYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGS 581
Query: 622 VLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQ 664
V AGVVGV+MPRYCLFGNNVTLA+KFES S PR+INVSPTTY+
Sbjct: 582 VFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYR 624
>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
sapiens]
Length = 455
Score = 535 bits (1378), Expect = e-152
Identities = 265/413 (64%), Positives = 326/413 (78%), Gaps = 1/413 (0%)
Query: 310 SQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQL-RCDTHKVLKFEDCFEIVS 368
S+ + L I + FC+ FPFH MFD M++LQ G G+R+ + R D FE+ FEI++
Sbjct: 34 SKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILT 93
Query: 369 PKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVD 428
PK+N TF ++ L+ FV+R + + + +VM++KGQMI++ ES++ILFLGSPCVD
Sbjct: 94 PKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVD 153
Query: 429 KLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKK 488
+L++ GRGL+LSDIPIH+A RDV+L+GEQA+AQDGLKKR+ KLKATLE+ HQALEEEKK
Sbjct: 154 RLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKK 213
Query: 489 KTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNE 548
KTVDLL SIFP +VAQQLWQGQ VQA+KF +VTMLFSDIVGFTAIC+QC+P+QVI+MLN
Sbjct: 214 KTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNA 273
Query: 549 LYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDG 608
LYTRFD QCG LD+YKVETIGDAYCVA GLH++S HA IALMALKMMELS+EV++P G
Sbjct: 274 LYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHG 333
Query: 609 RPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKR 668
PI+MRIG+HSGSV AGVVGV+MPRYCLFGNNVTLA+KFES S PR+INVSPTTY+LLK
Sbjct: 334 EPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD 393
Query: 669 EESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSYN 721
F F PRSREELP NFP EIPGIC+FL+ KP ++ + N
Sbjct: 394 CPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNAN 446
>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
Length = 619
Score = 340 bits (872), Expect = 3e-93
Identities = 205/543 (37%), Positives = 315/543 (58%), Gaps = 41/543 (7%)
Query: 154 ILQCTANILGLKFEEIQKRFGEEFFNICFHEN-ERVLRAVGGTLQDFFNGFDALLEHIRT 212
++ + +L L EI + FG+ FF C + +LR +G +++F DAL +H+ T
Sbjct: 51 LVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLAT 110
Query: 213 SFGKQATLESPSFLCKELPEGT-LMLHYFHPHHIVGFAMLGMIKAAGKKIY--RLDVEVE 269
+ + +PSF C + +G L+LHY+ + ++G+IK ++I+ +D++V
Sbjct: 111 IY---PGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVI 167
Query: 270 QVANEKLCSDVSNPGNCSCLTFLI--KECENTNIMKNLPQGTSQVPADLRISINTFCRAF 327
Q NE+ C FLI KE + + ++L + + RIS TFC+AF
Sbjct: 168 QQRNEE----------CDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAF 217
Query: 328 PFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKFEDCFEIVSPKVNATFERVLLRLSTPFV 387
PFH++FD + V Q G + + L F +V P ++ +F +L ++T FV
Sbjct: 218 PFHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFV 277
Query: 388 IRTKP------------EASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMG 435
+R+K E +G+E + +KGQMI++PE++SILFL SP V LD+L
Sbjct: 278 LRSKEGLLDVEKLECEDELTGTEIS--CLRLKGQMIYLPEADSILFLCSPSVMNLDDLTR 335
Query: 436 RGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLY 495
RGL+LSDIP+HDATRD++L+GEQ + + L + ++ L L+ T +ALE+EKKKT LLY
Sbjct: 336 RGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLY 395
Query: 496 SIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCT----PMQVISMLNELYT 551
S+ P VA +L + V A+++D+VT+LFS IVGF A C++ M+++++LN+LYT
Sbjct: 396 SVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYT 455
Query: 552 RFDHQCGFLD---IYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDG 608
RFD +YKVET+GD Y +GL + HA+ I +AL MME++ +V DG
Sbjct: 456 RFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQV-DG 514
Query: 609 RPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKR 668
+Q+ IGIH+G V+ GV+G RMPRYCLFGN V L S+ E+ +INVS TY+ L
Sbjct: 515 ESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMS 574
Query: 669 EES 671
E+
Sbjct: 575 PEN 577
>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
Length = 1047
Score = 181 bits (459), Expect = 2e-45
Identities = 104/211 (49%), Positives = 136/211 (64%), Gaps = 7/211 (3%)
Query: 463 DGLKKRMDK----LKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFD 518
D L RM++ L+ +E QA EEK+K LLY I P VA+QL +G+ VQA FD
Sbjct: 799 DNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFD 858
Query: 519 DVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGL 578
VT+ FSDIVGFTA+ A+ TPMQV+++LN+LYT FD D+YKVETIGDAY V +GL
Sbjct: 859 SVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGL 918
Query: 579 -HRKSLCHAKPIALMALKMMEL--SEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYC 635
R HA IA MAL +++ S + +++RIG+H+G V AGVVG++MPRYC
Sbjct: 919 PGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYC 978
Query: 636 LFGNNVTLASKFESGSHPRRINVSPTTYQLL 666
LFG+ V AS+ ES +I+VS TT L
Sbjct: 979 LFGDTVNTASRMESNGQALKIHVSSTTKDAL 1009
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 181 bits (459), Expect = 2e-45
Identities = 105/227 (46%), Positives = 141/227 (62%), Gaps = 7/227 (3%)
Query: 463 DGLKKRMDK----LKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFD 518
D L RM++ L+ +E QA EEK+K LLY I P VA+QL +G+ VQA FD
Sbjct: 814 DNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFD 873
Query: 519 DVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGL 578
VT+ FSDIVGFTA+ A+ TPMQV+++LN+LYT FD D+YKVETIGDAY V +GL
Sbjct: 874 SVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGL 933
Query: 579 H-RKSLCHAKPIALMALKMMEL--SEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYC 635
R HA +A MAL +++ S + +++RIGIH+G V AGVVG++MPRYC
Sbjct: 934 PVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYC 993
Query: 636 LFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREEL 682
LFG+ V AS+ ES +I++S T +L+ F R E+
Sbjct: 994 LFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEM 1040
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 167 bits (424), Expect = 2e-41
Identities = 104/236 (44%), Positives = 145/236 (61%), Gaps = 10/236 (4%)
Query: 456 GEQAKAQDGLKKRMDKLKATLE-----RTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQ 510
G++ D + + +++ + LE RT + LE EK+KT LL + P VA+ L +G
Sbjct: 815 GKKTNIIDSMLRMLEQYSSNLEDLIRERTEE-LEIEKQKTEKLLTQMLPPSVAESLKKGC 873
Query: 511 QVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGD 570
V+ FD VT+ FSDIVGFT I A P++V+ +LN+LYT FD G D+YKVETIGD
Sbjct: 874 TVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGD 933
Query: 571 AYCVAAGL-HRKSLCHAKPIALMALKMMEL--SEEVLTPDGRPIQMRIGIHSGSVLAGVV 627
AY VA+GL R HA IA M+L ++ + ++ P+++RIG+HSG V+AGVV
Sbjct: 934 AYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVV 993
Query: 628 GVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKR-EESFTFIPRSREEL 682
G+ MPRYCLFG+ V AS+ ES P RI+VS +T +L+ E + R R EL
Sbjct: 994 GLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTEL 1049
>gi|222080083 guanylate cyclase 2C [Homo sapiens]
Length = 1073
Score = 164 bits (416), Expect = 2e-40
Identities = 93/202 (46%), Positives = 127/202 (62%), Gaps = 3/202 (1%)
Query: 472 LKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFT 531
L+ +E Q + E+ + L + + P V + L + V+ +++VT+ FSDIVGFT
Sbjct: 775 LEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFT 834
Query: 532 AICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGL-HRKSLCHAKPIA 590
IC TPM+V+ MLN++Y FDH D+YKVETIGDAY VA+GL R HA IA
Sbjct: 835 TICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIA 894
Query: 591 LMALKMMEL--SEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFE 648
MAL+++ + E+ G PI +RIG+HSG AGVVG++MPRYCLFG+ V AS+ E
Sbjct: 895 KMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRME 954
Query: 649 SGSHPRRINVSPTTYQLLKREE 670
S P RI+VS +T +LKR E
Sbjct: 955 STGLPLRIHVSGSTIAILKRTE 976
>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
sapiens]
Length = 1103
Score = 164 bits (416), Expect = 2e-40
Identities = 115/287 (40%), Positives = 161/287 (56%), Gaps = 22/287 (7%)
Query: 444 PIHDATRDV---ILVGEQAKAQDGLKKRMDKLKATLE-----RTHQALEEEKKKTVDLLY 495
P D T D+ I G + D + + +++ + LE RT + LE EK+KT LL
Sbjct: 796 PSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEE-LELEKQKTDRLLT 854
Query: 496 SIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDH 555
+ P VA+ L G V+ F+ VT+ FSDIVGFT I A P++V+ +LN+LYT FD
Sbjct: 855 QMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDA 914
Query: 556 QCGFLDIYKVETIGDAYCVAAGL-HRKSLCHAKPIALMALKMMEL--SEEVLTPDGRPIQ 612
G D+YKVETIGDAY VA+GL R HA IA M+L ++ + + P++
Sbjct: 915 IIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVR 974
Query: 613 MRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREES- 671
+RIG+HSG +AGVVG+ MPRYCLFG+ V AS+ ES P RI+V+ +T +L+ +S
Sbjct: 975 IRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSG 1034
Query: 672 FTFIPRSREELPDNFPKEIPGICYFLEVRTG-----PKPPKPSLSSS 713
+ R R EL ++ ++L R G PKPP SS
Sbjct: 1035 YQVELRGRTELKGKGAED----TFWLVGRRGFNKPIPKPPDLQPGSS 1077
>gi|194595480 guanylate cyclase 1, soluble, alpha 3 isoform C [Homo
sapiens]
Length = 366
Score = 156 bits (395), Expect = 6e-38
Identities = 114/370 (30%), Positives = 178/370 (48%), Gaps = 36/370 (9%)
Query: 27 GECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVN 86
GECP S L + P E + ++ + A P + +R R RV
Sbjct: 13 GECPFSLLA--PGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVY 70
Query: 87 LDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKE 146
L +L ESI +L P + + L+RTL +H++ +++ K+
Sbjct: 71 LHTLAESICKLIFPEFERLNVALQRTLA--KHKI---KESRKSL---------------- 109
Query: 147 EIEDVSGILQCTANILGLKFEEIQKRFGEEFFNICFHENERVLRAVGGTLQDFFNGFDAL 206
E ED + A G+ E I++ GEE F IC+ E+E +L VGGTL+DF N F L
Sbjct: 110 EREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTL 169
Query: 207 LE---HIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYR 263
L+ H + + GK+ LE S LC + + L ++YF P + G+IKAA +Y
Sbjct: 170 LKQSSHCQEA-GKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYE 228
Query: 264 LDVEVEQVANEKLCSDVSNPGNCSCLTFLI-KECENTNIMKNLPQGTSQVPADLRISINT 322
+VEV + +D S N L + + + ++ + PQ + +P L
Sbjct: 229 TEVEV-SLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSL------ 281
Query: 323 FCRAFPFHLMFDPSMSVLQLGEGLRKQL-RCDTHKVLKFEDCFEIVSPKVNATFERVLLR 381
FC+ FPFH MFD M++LQ G G+R+ + R D FE+ FEI++PK+N TF ++
Sbjct: 282 FCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTM 341
Query: 382 LSTPFVIRTK 391
L+ FV+R +
Sbjct: 342 LNMQFVVRVR 351
>gi|31083193 adenylate cyclase 1 [Homo sapiens]
Length = 1119
Score = 117 bits (293), Expect = 4e-26
Identities = 62/193 (32%), Positives = 110/193 (56%), Gaps = 9/193 (4%)
Query: 483 LEEEKKKTVDLLYSIFPGDVAQQLWQG---------QQVQARKFDDVTMLFSDIVGFTAI 533
LE+E +K LL S+ P +VA ++ + ++ ++ D+V++LF+DIVGFT +
Sbjct: 256 LEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGL 315
Query: 534 CAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMA 593
+QCT +++ +LNEL+ +FD +++ +GD Y +GL + HA M
Sbjct: 316 ASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMG 375
Query: 594 LKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHP 653
L M++ V + MR+G+H+G VL GV+G+R +Y ++ N+VTLA+ E+ P
Sbjct: 376 LDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLP 435
Query: 654 RRINVSPTTYQLL 666
+++++ TT L
Sbjct: 436 GKVHITKTTLACL 448
Score = 90.5 bits (223), Expect = 5e-18
Identities = 71/260 (27%), Positives = 126/260 (48%), Gaps = 25/260 (9%)
Query: 462 QDGLKKRMDKL-KATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLW----QGQQVQARK 516
Q ++ R+D L A E + +E+ K +L+++ P VAQ + + +
Sbjct: 804 QVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQS 863
Query: 517 FDDVTMLFSDIVGFTAICAQCTP----MQVISMLNELYTRFDHQCG---FLDIYKVETIG 569
+ V ++F+ I F + ++ + +LNE+ FD + DI K++TIG
Sbjct: 864 YSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIG 923
Query: 570 DAYCVAAGLH-------RKSLC-HAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGS 621
Y A GL +KS+ H +A A++M ++ +E+ +R+GI+ G
Sbjct: 924 STYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGP 983
Query: 622 VLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREE 681
V+AGV+G R P+Y ++GN V +AS+ +S RI V+ ++LL+R + F+ R +
Sbjct: 984 VVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRR-CPYHFVCRGKVS 1042
Query: 682 LPDNFPKEIPGICYFLEVRT 701
+ + YFLE RT
Sbjct: 1043 VKGKGEM----LTYFLEGRT 1058
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 116 bits (290), Expect = 8e-26
Identities = 66/203 (32%), Positives = 114/203 (56%), Gaps = 19/203 (9%)
Query: 483 LEEEKKKTVDLLYSIFPGDVAQQL-------WQGQQ------------VQARKFDDVTML 523
LE EK++ LL S+ P +A ++ QG + + ++ +V++L
Sbjct: 233 LEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSIL 292
Query: 524 FSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSL 583
++DIVGFT + + C+P +++ MLNEL+ +FD + +++ +GD Y +GL
Sbjct: 293 YADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLP 352
Query: 584 CHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTL 643
HAK M L M E ++V G I MR+G+HSG+VL GV+G++ +Y ++ ++VTL
Sbjct: 353 NHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTL 412
Query: 644 ASKFESGSHPRRINVSPTTYQLL 666
A+ E+G P R+++S T + L
Sbjct: 413 ANHMEAGGVPGRVHISSVTLEHL 435
Score = 68.6 bits (166), Expect = 2e-11
Identities = 52/223 (23%), Positives = 102/223 (45%), Gaps = 23/223 (10%)
Query: 468 RMDKL-KATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLW----QGQQVQARKFDDVTM 522
R+D L K ++ + +E + LL ++ P VA+ + +++ + +D V +
Sbjct: 829 RLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCV 888
Query: 523 LFSDIVGFTAICAQCTP----MQVISMLNELYTRFDHQCG---FLDIYKVETIGDAYCVA 575
+F+ I F + ++ + +LNE+ FD F + K++TIG Y A
Sbjct: 889 MFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAA 948
Query: 576 AGLH-----------RKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLA 624
GL + H + A ++ + + ++R+GI+ G V+A
Sbjct: 949 TGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIA 1008
Query: 625 GVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLK 667
GV+G + P+Y ++GN V +AS+ +S +I V+ T +L+
Sbjct: 1009 GVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQ 1051
>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
Length = 1168
Score = 114 bits (286), Expect = 2e-25
Identities = 64/194 (32%), Positives = 106/194 (54%), Gaps = 10/194 (5%)
Query: 483 LEEEKKKTVDLLYSIFPGDVAQQLWQG----------QQVQARKFDDVTMLFSDIVGFTA 532
L+ E ++ LL S+ P VA ++ + ++ +K D+V++LF+DI GFT+
Sbjct: 331 LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS 390
Query: 533 ICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALM 592
+ +QCT +++ LNEL+ RFD +++ +GD Y +GL HA M
Sbjct: 391 LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM 450
Query: 593 ALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSH 652
+ M+E V G + MR+GIHSG V GV+G+R ++ ++ N+VTLA+ E+G
Sbjct: 451 GVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGR 510
Query: 653 PRRINVSPTTYQLL 666
RI+++ T Q L
Sbjct: 511 AGRIHITRATLQYL 524
Score = 92.4 bits (228), Expect = 1e-18
Identities = 62/212 (29%), Positives = 110/212 (51%), Gaps = 18/212 (8%)
Query: 471 KLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLW----QGQQVQARKFDDVTMLFSD 526
KL+AT E+ + +EE + LL++I P DVA + ++ + + V ++F+
Sbjct: 927 KLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFAS 984
Query: 527 IVGFTAICAQCTP----MQVISMLNELYTRFDHQCG---FLDIYKVETIGDAYCVAAGLH 579
I F+ + ++ + +LNE+ FD F + K++TIG Y A+GL+
Sbjct: 985 IANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLN 1044
Query: 580 RKSL-----CHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRY 634
+ H +A A+++ME + + QM+IG++ G V+AGV+G R P+Y
Sbjct: 1045 ASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQY 1104
Query: 635 CLFGNNVTLASKFESGSHPRRINVSPTTYQLL 666
++GN V ++S+ +S P RI V+ YQ+L
Sbjct: 1105 DIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1136
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 114 bits (286), Expect = 2e-25
Identities = 64/194 (32%), Positives = 106/194 (54%), Gaps = 10/194 (5%)
Query: 483 LEEEKKKTVDLLYSIFPGDVAQQLWQG----------QQVQARKFDDVTMLFSDIVGFTA 532
L+ E ++ LL S+ P VA ++ + ++ +K D+V++LF+DI GFT+
Sbjct: 331 LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS 390
Query: 533 ICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALM 592
+ +QCT +++ LNEL+ RFD +++ +GD Y +GL HA M
Sbjct: 391 LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM 450
Query: 593 ALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSH 652
+ M+E V G + MR+GIHSG V GV+G+R ++ ++ N+VTLA+ E+G
Sbjct: 451 GVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGR 510
Query: 653 PRRINVSPTTYQLL 666
RI+++ T Q L
Sbjct: 511 AGRIHITRATLQYL 524
Score = 92.4 bits (228), Expect = 1e-18
Identities = 62/212 (29%), Positives = 110/212 (51%), Gaps = 18/212 (8%)
Query: 471 KLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLW----QGQQVQARKFDDVTMLFSD 526
KL+AT E+ + +EE + LL++I P DVA + ++ + + V ++F+
Sbjct: 874 KLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFAS 931
Query: 527 IVGFTAICAQCTP----MQVISMLNELYTRFDHQCG---FLDIYKVETIGDAYCVAAGLH 579
I F+ + ++ + +LNE+ FD F + K++TIG Y A+GL+
Sbjct: 932 IANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLN 991
Query: 580 RKSL-----CHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRY 634
+ H +A A+++ME + + QM+IG++ G V+AGV+G R P+Y
Sbjct: 992 ASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQY 1051
Query: 635 CLFGNNVTLASKFESGSHPRRINVSPTTYQLL 666
++GN V ++S+ +S P RI V+ YQ+L
Sbjct: 1052 DIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1083
>gi|148536830 adenylate cyclase 3 [Homo sapiens]
Length = 1144
Score = 113 bits (283), Expect = 5e-25
Identities = 65/200 (32%), Positives = 112/200 (56%), Gaps = 13/200 (6%)
Query: 483 LEEEKKKTVDLLYSIFPGDVAQQLW------QGQQVQAR-------KFDDVTMLFSDIVG 529
LEE+ ++ +L+ SI P VA ++ + Q+ Q + + ++V++LF+DIVG
Sbjct: 268 LEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVG 327
Query: 530 FTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPI 589
FT + + C+ +++ +LNEL+ RFD +++ +GD Y GL HA
Sbjct: 328 FTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCS 387
Query: 590 ALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFES 649
LM L M+E V + MR+G+H+G+VL GV+G + +Y ++ +VT+A+K E+
Sbjct: 388 ILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEA 447
Query: 650 GSHPRRINVSPTTYQLLKRE 669
G P R+++S +T LK E
Sbjct: 448 GGIPGRVHISQSTMDCLKGE 467
Score = 75.1 bits (183), Expect = 2e-13
Identities = 61/247 (24%), Positives = 113/247 (45%), Gaps = 37/247 (14%)
Query: 467 KRMDKLKATLERTHQALEEEKKKTVD-------LLYSIFPGDVAQQLW----QGQQVQAR 515
+ ++KL TL + ++K++ + L+ ++ P VA+ + +++ ++
Sbjct: 858 RHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQ 917
Query: 516 KFDDVTMLFSDIVGFTAICAQCT----PMQVISMLNELYTRFDHQCG---FLDIYKVETI 568
+D++ ++F+ + F + + ++ + LNE+ + FD F I K++TI
Sbjct: 918 TYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTI 977
Query: 569 GDAYCVAAGL------------------HRKSLCHAKPIALMALKMMELSEEVLTPDGRP 610
G Y A+G+ R+ H +A AL M + +
Sbjct: 978 GSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNN 1037
Query: 611 IQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREE 670
+RIG++ G VLAGV+G R P Y ++GN V +AS+ ES I V T Q++ RE
Sbjct: 1038 FMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEET-QVILREY 1096
Query: 671 SFTFIPR 677
F F+ R
Sbjct: 1097 GFRFVRR 1103
>gi|24497587 adenylate cyclase 4 [Homo sapiens]
Length = 1077
Score = 113 bits (283), Expect = 5e-25
Identities = 65/207 (31%), Positives = 114/207 (55%), Gaps = 19/207 (9%)
Query: 479 THQALEEEKKKTVDLLYSIFPGDVAQQL----------WQGQQVQA---------RKFDD 519
+ + L+ EKK LL SI P +A+++ QG + ++ ++
Sbjct: 212 SRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQG 271
Query: 520 VTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLH 579
V++L++DIVGFT + ++C+P +++ MLNEL+ +FD + +++ +GD Y +GL
Sbjct: 272 VSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLP 331
Query: 580 RKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGN 639
HA M L M ++ G I MR+G+HSGSVL GV+G++ +Y ++ +
Sbjct: 332 LSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSH 391
Query: 640 NVTLASKFESGSHPRRINVSPTTYQLL 666
+VTLA+ E+G P R++++ T LL
Sbjct: 392 DVTLANHMEAGGVPGRVHITGATLALL 418
Score = 70.1 bits (170), Expect = 7e-12
Identities = 54/218 (24%), Positives = 101/218 (46%), Gaps = 23/218 (10%)
Query: 468 RMDKL-KATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLW----QGQQVQARKFDDVTM 522
R+D L K L + + E + T LL ++ P VA Q + + + + ++ V +
Sbjct: 815 RLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCV 874
Query: 523 LFSDIVGFTAICAQCT----PMQVISMLNELYTRFDHQCG---FLDIYKVETIGDAYCVA 575
LF+ + F ++ ++ + +LNE+ FD F + K++TIG Y A
Sbjct: 875 LFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAA 934
Query: 576 AGLH-----------RKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLA 624
GL+ +S H + A+ + + + ++R+G++ G V+A
Sbjct: 935 TGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVA 994
Query: 625 GVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTT 662
GV+G + P+Y ++GN V +AS+ ES +I V+ T
Sbjct: 995 GVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEET 1032
>gi|4557255 adenylate cyclase 7 [Homo sapiens]
Length = 1080
Score = 112 bits (280), Expect = 1e-24
Identities = 69/253 (27%), Positives = 127/253 (50%), Gaps = 22/253 (8%)
Query: 483 LEEEKKKTVDLLYSIFPGDVAQQLWQG-------------------QQVQARKFDDVTML 523
L EK++ +LL S+ P ++ + + ++ +V++L
Sbjct: 222 LRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSIL 281
Query: 524 FSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSL 583
++DIVGFT + + C+P +++ +LNEL+ +FD + +++ +GD Y +GL
Sbjct: 282 YADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLP 341
Query: 584 CHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTL 643
HA+ M L M + ++V G I MR+GIHSG+VL GV+G+R +Y ++ ++V+L
Sbjct: 342 THARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSL 401
Query: 644 ASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGP 703
A++ E+ P R++++ T LK + + + D + KE+ Y +
Sbjct: 402 ANRMEAAGVPGRVHITEAT---LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQ 458
Query: 704 KPPKPSLSSSRIK 716
+PP PS R K
Sbjct: 459 QPPPPSQHLPRPK 471
Score = 77.8 bits (190), Expect = 3e-14
Identities = 57/222 (25%), Positives = 105/222 (47%), Gaps = 23/222 (10%)
Query: 468 RMDKL-KATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQA----RKFDDVTM 522
R+D L K ++ H+ E + LL ++ P VA + G ++ + +D V +
Sbjct: 822 RLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAH-FIGDKLNEDWYHQSYDCVCV 880
Query: 523 LFSDIVGFTAICAQCTP----MQVISMLNELYTRFDH---QCGFLDIYKVETIGDAYCVA 575
+F+ + F +C ++ + +LNE+ FD + F + K++TIG Y A
Sbjct: 881 MFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAA 940
Query: 576 AGLH----------RKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAG 625
AGL + H + ++ +M + + ++R+GI+ G V+AG
Sbjct: 941 AGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAG 1000
Query: 626 VVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLK 667
V+G R P+Y ++GN V +AS+ ES +I V+ T +L+
Sbjct: 1001 VIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQ 1042
>gi|34486092 adenylate cyclase 5 [Homo sapiens]
Length = 1261
Score = 110 bits (276), Expect = 4e-24
Identities = 64/199 (32%), Positives = 106/199 (53%), Gaps = 12/199 (6%)
Query: 478 RTHQALEEEKKKTVDLLYSIFPGDVAQQL----------WQGQQVQARKFDDVTMLFSDI 527
R H E ++++ LL S+ P VA ++ ++ +K D+V++LF+DI
Sbjct: 418 RLHSQRENQQQER--LLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADI 475
Query: 528 VGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAK 587
GFT++ +QCT +++ LNEL+ RFD +++ +GD Y +GL HA
Sbjct: 476 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 535
Query: 588 PIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKF 647
M + M+E V G + MR+GIHSG V GV+G+R ++ ++ N+VTLA+
Sbjct: 536 CCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 595
Query: 648 ESGSHPRRINVSPTTYQLL 666
E+G RI+++ T L
Sbjct: 596 EAGGKAGRIHITKATLNYL 614
Score = 95.5 bits (236), Expect = 2e-19
Identities = 64/212 (30%), Positives = 112/212 (52%), Gaps = 18/212 (8%)
Query: 471 KLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLW----QGQQVQARKFDDVTMLFSD 526
KL+AT E+ + +EE + LL++I P DVA + ++ + + V ++F+
Sbjct: 1019 KLQATEEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFAS 1076
Query: 527 IVGFTAICAQCTP----MQVISMLNELYTRFDH---QCGFLDIYKVETIGDAYCVAAGLH 579
I F+ + ++ + +LNE+ FD + F + K++TIG Y A+GL+
Sbjct: 1077 IANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLN 1136
Query: 580 RKSL-----CHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRY 634
+ H K +A A+K+M+ + + QM+IG++ G V+AGV+G R P+Y
Sbjct: 1137 DSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQY 1196
Query: 635 CLFGNNVTLASKFESGSHPRRINVSPTTYQLL 666
++GN V +AS+ +S P RI V+ YQ+L
Sbjct: 1197 DIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL 1228
>gi|4557257 adenylate cyclase 8 [Homo sapiens]
Length = 1251
Score = 103 bits (257), Expect = 6e-22
Identities = 61/197 (30%), Positives = 103/197 (52%), Gaps = 13/197 (6%)
Query: 483 LEEEKKKTVDLLYSIFPGDVAQQL-------------WQGQQVQARKFDDVTMLFSDIVG 529
LE E ++ L+ S+ P V ++ Q ++ ++++V++LF+D+ G
Sbjct: 363 LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKG 422
Query: 530 FTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPI 589
FT + + +++ MLNEL+ RFD +++ +GD Y +GL HA
Sbjct: 423 FTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCC 482
Query: 590 ALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFES 649
M L M++ V + + MRIGIHSGSVL GV+G+R ++ ++ +V +A+K ES
Sbjct: 483 VEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLES 542
Query: 650 GSHPRRINVSPTTYQLL 666
G P RI++S T L
Sbjct: 543 GGIPGRIHISKATLDCL 559
Score = 98.2 bits (243), Expect = 2e-20
Identities = 72/240 (30%), Positives = 119/240 (49%), Gaps = 18/240 (7%)
Query: 483 LEEEKKKTVDLLYSIFPGDVAQQLWQ----GQQVQARKFDDVTMLFSDIVGFTAICAQCT 538
++E ++ ++L +I P VA+ + +++ ++ +D V ++F+ I GF +Q
Sbjct: 940 MKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTE 999
Query: 539 P----MQVISMLNELYTRFDHQCG---FLDIYKVETIGDAYCVAAGLH-RKSLC-----H 585
++ + +LNE+ FD G F DI K++TIG Y +GL K C H
Sbjct: 1000 MNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGH 1059
Query: 586 AKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLAS 645
+A +L + E +E+ ++RIGI GSV+AGV+G + P+Y ++G V LAS
Sbjct: 1060 LCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLAS 1119
Query: 646 KFESGSHPRRINVSPTTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKP 705
+ +S RI V TY +LK ++ F F R + +E YFL R P P
Sbjct: 1120 RMDSTGVSGRIQVPEETYLILK-DQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNP 1178
>gi|50959205 adenylate cyclase 9 [Homo sapiens]
Length = 1353
Score = 98.2 bits (243), Expect = 2e-20
Identities = 63/231 (27%), Positives = 123/231 (53%), Gaps = 11/231 (4%)
Query: 438 LHLSDIPIHDATRDVIL--VGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLY 495
+H D+ + A ++ ++ V + A D +K+ ++ + +++R + + +KK
Sbjct: 318 MHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKS---- 373
Query: 496 SIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDH 555
SI +A + ++ QQ++ +V++LF+DIVGFT + A + ++ +LN+L+ RFD
Sbjct: 374 SIQKAPIAFRPFKMQQIE-----EVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDR 428
Query: 556 QCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRI 615
C K+ T+GD Y AG HA M L M++ E+ + MR+
Sbjct: 429 LCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRV 488
Query: 616 GIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLL 666
G+H+G+VL G++G+R ++ ++ N+V LA+ E ++++S T + L
Sbjct: 489 GVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYL 539
Score = 60.8 bits (146), Expect = 4e-09
Identities = 55/210 (26%), Positives = 101/210 (48%), Gaps = 16/210 (7%)
Query: 472 LKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFT 531
++A L RT ++ + + LL +I P VA+QL + Q ++ D ++F+ IV F+
Sbjct: 1012 VEADLHRTK--IQSMRDQADWLLRNIIPYHVAEQL-KVSQTYSKNHDSGGVIFASIVNFS 1068
Query: 532 AICAQCTP--MQVISMLNELYTRFDHQCG---FLDIYKVETIGDAYCVAAGLHRKSLC-- 584
+ + +LNEL FD + I K++TIG Y A+GL+
Sbjct: 1069 EFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDG 1128
Query: 585 -----HAKPIALMALKMMELSEEVLTPD-GRPIQMRIGIHSGSVLAGVVGVRMPRYCLFG 638
H + + A +MM + ++ ++R+G + G + AGV+G Y ++G
Sbjct: 1129 SHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWG 1188
Query: 639 NNVTLASKFESGSHPRRINVSPTTYQLLKR 668
+ V +AS+ ++ RI VS +Y++L +
Sbjct: 1189 DTVNIASRMDTTGVECRIQVSEESYRVLSK 1218
>gi|154146199 sal-like 3 [Homo sapiens]
Length = 1300
Score = 43.5 bits (101), Expect = 7e-04
Identities = 27/55 (49%), Positives = 34/55 (61%), Gaps = 5/55 (9%)
Query: 26 EGECPLSRLCWNGSRSPPGPLEPS----PAAAAAAAAPAPTPAASAAAAAATAGA 76
EG PLSR +G+ +P GP EPS P+AA A AAPAP PA +AA++ A
Sbjct: 287 EGAQPLSRP-ESGASTPGGPAEPSAPAAPSAAPAPAAPAPAPAPQSAASSQPQSA 340
Score = 31.2 bits (69), Expect = 3.6
Identities = 18/37 (48%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 40 RSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGA 76
R PP P SPAAA +A PAP+ AA +AGA
Sbjct: 235 RPPPRP-SLSPAAAPSAPGPAPSQLPGLAALPLSAGA 270
>gi|15967156 SCAN domain containing protein 1 [Homo sapiens]
Length = 179
Score = 38.9 bits (89), Expect = 0.017
Identities = 36/116 (31%), Positives = 51/116 (43%), Gaps = 14/116 (12%)
Query: 41 SPPGPLEPSPAAAAAAAAPAPTPAASAA-----AAAATAGARRVQRRRRVNLDSLGESIS 95
SPP P SP AA A P P AASAA A + A + + R + G + S
Sbjct: 44 SPPAPEPSSPNAAVPEAIPTPRAAASAALELPLGPAPVSVAPQAEAEAR---STPGPAGS 100
Query: 96 RLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKEEIEDV 151
RL P+T +Q R Q+ G R+A + +S + D KE+I ++
Sbjct: 101 RL---GPETFRQ---RFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEM 150
>gi|7706089 SCAN domain containing protein 1 [Homo sapiens]
Length = 179
Score = 38.9 bits (89), Expect = 0.017
Identities = 36/116 (31%), Positives = 51/116 (43%), Gaps = 14/116 (12%)
Query: 41 SPPGPLEPSPAAAAAAAAPAPTPAASAA-----AAAATAGARRVQRRRRVNLDSLGESIS 95
SPP P SP AA A P P AASAA A + A + + R + G + S
Sbjct: 44 SPPAPEPSSPNAAVPEAIPTPRAAASAALELPLGPAPVSVAPQAEAEAR---STPGPAGS 100
Query: 96 RLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKEEIEDV 151
RL P+T +Q R Q+ G R+A + +S + D KE+I ++
Sbjct: 101 RL---GPETFRQ---RFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEM 150
>gi|5031759 homeobox A11 [Homo sapiens]
Length = 313
Score = 38.5 bits (88), Expect = 0.022
Identities = 40/145 (27%), Positives = 65/145 (44%), Gaps = 21/145 (14%)
Query: 44 GPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRV-------QRRRRVNLDSLGESISR 96
GP + +AAAAAA PA S++ + G R +RRRR S ES S
Sbjct: 168 GPPAATATSAAAAAAATGAPATSSSDSGGGGGCRETAAAAEEKERRRRPESSSSPESSSG 227
Query: 97 LTAPSP--QTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGI 154
T + Q+T K+ Y ++Q+ R+ E+ F ++ + NKE+ +S +
Sbjct: 228 HTEDKAGGSSGQRTRKKRCPYTKYQI---RELEREFF-------FSVYINKEKRLQLSRM 277
Query: 155 LQCTANILGLKFEEIQKRFGEEFFN 179
L T + + F+ +R E+ N
Sbjct: 278 LNLTDRQVKIWFQ--NRRMKEKKIN 300
>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
Length = 538
Score = 38.5 bits (88), Expect = 0.022
Identities = 19/31 (61%), Positives = 20/31 (64%)
Query: 42 PPGPLEPSPAAAAAAAAPAPTPAASAAAAAA 72
PP P P P A AAAAPA P A+AAAA A
Sbjct: 128 PPTPAPPPPPAPVAAAAPARAPRAAAAAATA 158
Score = 34.7 bits (78), Expect = 0.32
Identities = 19/37 (51%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 43 PGPLEPSPAAAAAAAAPAPTPA-ASAAAAAATAGARR 78
PGP +P P A AA AP PA A+ A A AG RR
Sbjct: 162 PGPAQPGPRAQRAAPLAAPPPAPAAPPAVAPPAGPRR 198
Score = 33.5 bits (75), Expect = 0.72
Identities = 21/41 (51%), Positives = 24/41 (58%), Gaps = 3/41 (7%)
Query: 41 SPPGPLEPSPAAAAAAA---APAPTPAASAAAAAATAGARR 78
+PP +PAAAAAAA PAP P + AAAA A A R
Sbjct: 110 APPRAPRGAPAAAAAAAPPPTPAPPPPPAPVAAAAPARAPR 150
>gi|118344456 UTP18, small subunit processome component [Homo
sapiens]
Length = 556
Score = 37.4 bits (85), Expect = 0.050
Identities = 43/165 (26%), Positives = 69/165 (41%), Gaps = 18/165 (10%)
Query: 30 PLSRLCWNGSRSPPGPLEPSPAAAAAAAAPA-PTPAASAAAAAATAGARRVQRRRRVNLD 88
P R W P GP + PA ++ PA P+ AA+A A AA RR+++R R+ L+
Sbjct: 23 PGMRPDWKAGAGPGGPPQ-KPAPSSQRKPPARPSAAAAAIAVAAAEEERRLRQRNRLRLE 81
Query: 89 SLGESISR----LTAPSPQTIQQTLKRTL---QYYEHQVIG----YRDAEKNFHNISNRC 137
++ R L + + L R L + EH+ G +A+ NF
Sbjct: 82 EDKPAVERCLEELVFGDVENDEDALLRRLRGPRVQEHEDSGDSEVENEAKGNFPPQKKPV 141
Query: 138 SYADHSNKEEIEDVSG-----ILQCTANILGLKFEEIQKRFGEEF 177
+ EE+ D+ + A+ L + ++KR EEF
Sbjct: 142 WVDEEDEDEEMVDMMNNRFRKDMMKNASESKLSKDNLKKRLKEEF 186
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,105,932
Number of Sequences: 37866
Number of extensions: 1445014
Number of successful extensions: 15337
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 148
Number of HSP's successfully gapped in prelim test: 143
Number of HSP's that attempted gapping in prelim test: 12931
Number of HSP's gapped (non-prelim): 1758
length of query: 732
length of database: 18,247,518
effective HSP length: 110
effective length of query: 622
effective length of database: 14,082,258
effective search space: 8759164476
effective search space used: 8759164476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.