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Search of human proteins with 4503503
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503503 eukaryotic translation initiation factor 2B, subunit
1 alpha, 26kDa [Homo sapiens]
(305 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503503 eukaryotic translation initiation factor 2B, subunit ... 592 e-169
gi|78000158 eukaryotic translation initiation factor 2B, subunit... 104 1e-22
gi|78000156 eukaryotic translation initiation factor 2B, subunit... 104 1e-22
gi|187607323 eukaryotic translation initiation factor 2B, subuni... 104 1e-22
gi|7657058 eukaryotic translation initiation factor 2B, subunit ... 91 1e-18
gi|72534748 translation initiation factor eIF-2B subunit alpha/b... 66 3e-11
gi|23943880 translation initiation factor eIF-2B subunit alpha/b... 59 7e-09
gi|45505155 F-box protein 38 isoform a [Homo sapiens] 31 1.2
gi|45545409 F-box protein 38 isoform b [Homo sapiens] 31 1.2
gi|45446745 aldo-keto reductase family 1, member C2 [Homo sapiens] 31 1.6
gi|4503285 aldo-keto reductase family 1, member C2 [Homo sapiens] 31 1.6
gi|5453543 aldo-keto reductase family 1, member C1 [Homo sapiens] 31 1.6
gi|13994250 tektin 3 [Homo sapiens] 31 1.6
gi|109948292 hypothetical protein LOC57614 [Homo sapiens] 30 2.0
gi|52627162 olfactory receptor, family 5, subfamily M, member 8 ... 30 2.7
gi|111185957 downstream of tyrosine kinase 7 [Homo sapiens] 29 4.5
gi|55956775 sterol carrier protein 2 isoform 2 [Homo sapiens] 29 4.5
>gi|4503503 eukaryotic translation initiation factor 2B, subunit 1
alpha, 26kDa [Homo sapiens]
Length = 305
Score = 592 bits (1526), Expect = e-169
Identities = 305/305 (100%), Positives = 305/305 (100%)
Query: 1 MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVD 60
MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVD
Sbjct: 1 MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVD 60
Query: 61 SSVAVSSGGELFLRFISLASLEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIK 120
SSVAVSSGGELFLRFISLASLEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIK
Sbjct: 61 SSVAVSSGGELFLRFISLASLEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIK 120
Query: 121 DGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLD 180
DGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLD
Sbjct: 121 DGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLD 180
Query: 181 AAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFP 240
AAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFP
Sbjct: 181 AAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFP 240
Query: 241 LNQQDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDEL 300
LNQQDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDEL
Sbjct: 241 LNQQDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDEL 300
Query: 301 IKLYL 305
IKLYL
Sbjct: 301 IKLYL 305
>gi|78000158 eukaryotic translation initiation factor 2B, subunit 4
delta isoform 2 [Homo sapiens]
Length = 523
Score = 104 bits (259), Expect = 1e-22
Identities = 63/202 (31%), Positives = 107/202 (52%), Gaps = 8/202 (3%)
Query: 103 RISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGK 162
+I L+ I+ + I +G IL + S +V R+L+ A +RF V V +S+P L G+
Sbjct: 311 KIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGR 370
Query: 163 KMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQ 222
++L H VP + +L A Y++ + V++GA ++ NG +++++GT Q+A+ A+A
Sbjct: 371 HTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAH 430
Query: 223 NKPFYVVAESFKFVR-----LFPLNQQDVPDKFKYKAD---TLKVAQTGQDLKEEHPWVD 274
N P V E++KF F N+ D PD + K L Q L+ + D
Sbjct: 431 NVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYD 490
Query: 275 YTAPSLITLLFTDLGVLTPSAV 296
T P L+ L+ T+LG++ S+V
Sbjct: 491 VTPPELVDLVITELGMIPCSSV 512
>gi|78000156 eukaryotic translation initiation factor 2B, subunit 4
delta isoform 3 [Homo sapiens]
Length = 522
Score = 104 bits (259), Expect = 1e-22
Identities = 63/202 (31%), Positives = 107/202 (52%), Gaps = 8/202 (3%)
Query: 103 RISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGK 162
+I L+ I+ + I +G IL + S +V R+L+ A +RF V V +S+P L G+
Sbjct: 310 KIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGR 369
Query: 163 KMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQ 222
++L H VP + +L A Y++ + V++GA ++ NG +++++GT Q+A+ A+A
Sbjct: 370 HTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAH 429
Query: 223 NKPFYVVAESFKFVR-----LFPLNQQDVPDKFKYKAD---TLKVAQTGQDLKEEHPWVD 274
N P V E++KF F N+ D PD + K L Q L+ + D
Sbjct: 430 NVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYD 489
Query: 275 YTAPSLITLLFTDLGVLTPSAV 296
T P L+ L+ T+LG++ S+V
Sbjct: 490 VTPPELVDLVITELGMIPCSSV 511
>gi|187607323 eukaryotic translation initiation factor 2B, subunit 4
delta isoform 1 [Homo sapiens]
Length = 543
Score = 104 bits (259), Expect = 1e-22
Identities = 63/202 (31%), Positives = 107/202 (52%), Gaps = 8/202 (3%)
Query: 103 RISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGK 162
+I L+ I+ + I +G IL + S +V R+L+ A +RF V V +S+P L G+
Sbjct: 331 KIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGR 390
Query: 163 KMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQ 222
++L H VP + +L A Y++ + V++GA ++ NG +++++GT Q+A+ A+A
Sbjct: 391 HTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAH 450
Query: 223 NKPFYVVAESFKFVR-----LFPLNQQDVPDKFKYKAD---TLKVAQTGQDLKEEHPWVD 274
N P V E++KF F N+ D PD + K L Q L+ + D
Sbjct: 451 NVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYD 510
Query: 275 YTAPSLITLLFTDLGVLTPSAV 296
T P L+ L+ T+LG++ S+V
Sbjct: 511 VTPPELVDLVITELGMIPCSSV 532
>gi|7657058 eukaryotic translation initiation factor 2B, subunit 2
beta, 39kDa [Homo sapiens]
Length = 351
Score = 91.3 bits (225), Expect = 1e-18
Identities = 66/221 (29%), Positives = 105/221 (47%), Gaps = 4/221 (1%)
Query: 86 YSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAK 145
Y++ + +IE L + + IA I I+T +SR V L+ A A K
Sbjct: 126 YAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEA-ARK 184
Query: 146 KRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGG 205
++F V V E P G +MA L + TV+ DAA+ +M + + VI+G + ++ NG
Sbjct: 185 RKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGA 244
Query: 206 IINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKVAQTG-- 263
+ GT+ +A+ AK + P V A FK FP N++D KF + L +
Sbjct: 245 LRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFP-NEEDSFHKFVAPEEVLPFTEGDIL 303
Query: 264 QDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLY 304
+ + P DY P LITL +++G PS + + +LY
Sbjct: 304 EKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELY 344
>gi|72534748 translation initiation factor eIF-2B subunit
alpha/beta/delta-like protein isoform 1 [Homo sapiens]
Length = 369
Score = 66.2 bits (160), Expect = 3e-11
Identities = 80/295 (27%), Positives = 128/295 (43%), Gaps = 23/295 (7%)
Query: 18 PDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVDSSVAVSSGG-ELFLRFI 76
P +A+ VA +R L FL T + N+ A L V + A G E +R
Sbjct: 70 PGLAALVAFVRDKLSFLV-----TARPTAVNMARAARDLADVAAREAEREGATEEAVRER 124
Query: 77 SLASLE---YSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGATILTHAYSRV 133
+ E D + I L R++ S K+ L H + + T Y
Sbjct: 125 VICCTEDMLEKDLRDNRSIGDLGARHLLERVAPSGGKVTVLTHC---NTGALATAGYG-T 180
Query: 134 VLRVLEAAVAAKKRFSVYVTESQPDLSGKKM-AKALCHLNVPVTVVLDAAVGYIMEKADL 192
L V+ + + + + TE++P G ++ A L + +P T++ D+ V M +
Sbjct: 181 ALGVIRSLHSLGRLEHAFCTETRPYNQGARLTAFELVYEQIPATLITDSMVAAAMAHRGV 240
Query: 193 --VIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKF-VRLFPLNQ---QDV 246
V+VGA+ VV NG NK+GT Q+A+ AK PFYV A S +RL + ++
Sbjct: 241 SAVVVGADRVVANGDTANKVGTYQLAIVAKHHGIPFYVAAPSSSCDLRLETGKEIIIEER 300
Query: 247 PDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLIT-LLFTDLGVLTPSAVSDEL 300
P + + +++A G + +P D T LIT + T+LGV P + L
Sbjct: 301 PGQELTDVNGVRIAAPG--IGVWNPAFDVTPHDLITGGIITELGVFAPEELRTAL 353
>gi|23943880 translation initiation factor eIF-2B subunit
alpha/beta/delta-like protein isoform 2 [Homo sapiens]
Length = 322
Score = 58.5 bits (140), Expect = 7e-09
Identities = 50/157 (31%), Positives = 79/157 (50%), Gaps = 10/157 (6%)
Query: 152 VTESQPDLSGKKM-AKALCHLNVPVTVVLDAAVGYIMEKADL--VIVGAEGVVENGGIIN 208
V E++P G ++ A L + +P T++ D+ V M + V+VGA+ VV NG N
Sbjct: 152 VLETRPYNQGARLTAFELVYEQIPATLITDSMVAAAMAHRGVSAVVVGADRVVANGDTAN 211
Query: 209 KIGTNQMAVCAKAQNKPFYVVAESFKF-VRLFPLNQ---QDVPDKFKYKADTLKVAQTGQ 264
K+GT Q+A+ AK PFYV A S +RL + ++ P + + +++A G
Sbjct: 212 KVGTYQLAIVAKHHGIPFYVAAPSSSCDLRLETGKEIIIEERPGQELTDVNGVRIAAPG- 270
Query: 265 DLKEEHPWVDYTAPSLIT-LLFTDLGVLTPSAVSDEL 300
+ +P D T LIT + T+LGV P + L
Sbjct: 271 -IGVWNPAFDVTPHDLITGGIITELGVFAPEELRTAL 306
>gi|45505155 F-box protein 38 isoform a [Homo sapiens]
Length = 1113
Score = 31.2 bits (69), Expect = 1.2
Identities = 22/67 (32%), Positives = 32/67 (47%), Gaps = 11/67 (16%)
Query: 187 MEKADLVIVGAEGVVENGGIINKIG---TNQMAVCAK--------AQNKPFYVVAESFKF 235
M ADLV G VVEN GII IG N++ C K + P+ +++ ++
Sbjct: 367 MANADLVKYGLADVVENPGIITDIGMKAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRW 426
Query: 236 VRLFPLN 242
RL +N
Sbjct: 427 TRLVDIN 433
>gi|45545409 F-box protein 38 isoform b [Homo sapiens]
Length = 1188
Score = 31.2 bits (69), Expect = 1.2
Identities = 22/67 (32%), Positives = 32/67 (47%), Gaps = 11/67 (16%)
Query: 187 MEKADLVIVGAEGVVENGGIINKIG---TNQMAVCAK--------AQNKPFYVVAESFKF 235
M ADLV G VVEN GII IG N++ C K + P+ +++ ++
Sbjct: 367 MANADLVKYGLADVVENPGIITDIGMKAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRW 426
Query: 236 VRLFPLN 242
RL +N
Sbjct: 427 TRLVDIN 433
>gi|45446745 aldo-keto reductase family 1, member C2 [Homo sapiens]
Length = 323
Score = 30.8 bits (68), Expect = 1.6
Identities = 22/76 (28%), Positives = 33/76 (43%), Gaps = 15/76 (19%)
Query: 206 IINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKVAQTGQD 265
I+NK G VC + + P++ NQ+ + D K K D + VA +
Sbjct: 176 ILNKPGLKYKPVCNQVECHPYF--------------NQRKLLDFCKSK-DIVLVAYSALG 220
Query: 266 LKEEHPWVDYTAPSLI 281
E PWVD +P L+
Sbjct: 221 SHREEPWVDPNSPVLL 236
>gi|4503285 aldo-keto reductase family 1, member C2 [Homo sapiens]
Length = 323
Score = 30.8 bits (68), Expect = 1.6
Identities = 22/76 (28%), Positives = 33/76 (43%), Gaps = 15/76 (19%)
Query: 206 IINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKVAQTGQD 265
I+NK G VC + + P++ NQ+ + D K K D + VA +
Sbjct: 176 ILNKPGLKYKPVCNQVECHPYF--------------NQRKLLDFCKSK-DIVLVAYSALG 220
Query: 266 LKEEHPWVDYTAPSLI 281
E PWVD +P L+
Sbjct: 221 SHREEPWVDPNSPVLL 236
>gi|5453543 aldo-keto reductase family 1, member C1 [Homo sapiens]
Length = 323
Score = 30.8 bits (68), Expect = 1.6
Identities = 22/76 (28%), Positives = 33/76 (43%), Gaps = 15/76 (19%)
Query: 206 IINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKVAQTGQD 265
I+NK G VC + + P++ NQ+ + D K K D + VA +
Sbjct: 176 ILNKPGLKYKPVCNQVECHPYF--------------NQRKLLDFCKSK-DIVLVAYSALG 220
Query: 266 LKEEHPWVDYTAPSLI 281
E PWVD +P L+
Sbjct: 221 SHREEPWVDPNSPVLL 236
>gi|13994250 tektin 3 [Homo sapiens]
Length = 490
Score = 30.8 bits (68), Expect = 1.6
Identities = 22/84 (26%), Positives = 41/84 (48%)
Query: 191 DLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKF 250
+L++V A + +N TN++A A A+NK +A++ + + + + +
Sbjct: 327 NLLVVTANEMWNQFNKVNLSFTNRIAETADAKNKIQTHLAKTLQEIFQTEMTIESIKKAI 386
Query: 251 KYKADTLKVAQTGQDLKEEHPWVD 274
K K LKVAQT D + P ++
Sbjct: 387 KDKTAFLKVAQTRLDERTRRPNIE 410
>gi|109948292 hypothetical protein LOC57614 [Homo sapiens]
Length = 1216
Score = 30.4 bits (67), Expect = 2.0
Identities = 16/25 (64%), Positives = 17/25 (68%)
Query: 30 LLEFLKRDKGETIQGLRANLTSAIE 54
+LEF R ETIQ LRANLT A E
Sbjct: 206 VLEFELRKAKETIQALRANLTKAAE 230
>gi|52627162 olfactory receptor, family 5, subfamily M, member 8
[Homo sapiens]
Length = 311
Score = 30.0 bits (66), Expect = 2.7
Identities = 21/86 (24%), Positives = 35/86 (40%), Gaps = 5/86 (5%)
Query: 104 ISLSRNKIADLCHTFIKDGATI-----LTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPD 158
+ S N + F+ + +I L Y + L +E + A F Y+ P
Sbjct: 70 LCFSSNVTPKMLEIFLSEKKSISYPACLVQCYLFIALVHVEIYILAVMAFDRYMAICNPL 129
Query: 159 LSGKKMAKALCHLNVPVTVVLDAAVG 184
L G +M+K++C + V V A G
Sbjct: 130 LYGSRMSKSVCSFLITVPYVYGALTG 155
>gi|111185957 downstream of tyrosine kinase 7 [Homo sapiens]
Length = 504
Score = 29.3 bits (64), Expect = 4.5
Identities = 12/31 (38%), Positives = 20/31 (64%)
Query: 30 LLEFLKRDKGETIQGLRANLTSAIETLCGVD 60
LL + +DK E I+GLR + +E +CG++
Sbjct: 36 LLMLVYKDKSERIKGLRERSSLTLEDICGLE 66
>gi|55956775 sterol carrier protein 2 isoform 2 [Homo sapiens]
Length = 322
Score = 29.3 bits (64), Expect = 4.5
Identities = 14/38 (36%), Positives = 21/38 (55%)
Query: 157 PDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVI 194
PDL+ + KAL +P + V A VGY+ A+ V+
Sbjct: 36 PDLAEEAGKKALADAQIPYSAVDQACVGYVFGVAECVL 73
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,668,171
Number of Sequences: 37866
Number of extensions: 360693
Number of successful extensions: 941
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 921
Number of HSP's gapped (non-prelim): 19
length of query: 305
length of database: 18,247,518
effective HSP length: 102
effective length of query: 203
effective length of database: 14,385,186
effective search space: 2920192758
effective search space used: 2920192758
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.