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Search of human proteins with 4503313
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503313 diacylglycerol kinase epsilon [Homo sapiens]
(567 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503313 diacylglycerol kinase epsilon [Homo sapiens] 1194 0.0
gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens] 284 1e-76
gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 276 4e-74
gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 276 4e-74
gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 276 4e-74
gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 276 4e-74
gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens] 274 2e-73
gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens] 273 4e-73
gi|40806175 diacylglycerol kinase, theta [Homo sapiens] 251 2e-66
gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens] 245 7e-65
gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens] 242 8e-64
gi|4758156 diacylglycerol kinase, iota [Homo sapiens] 231 1e-60
gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens] 217 2e-56
gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens] 217 2e-56
gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens] 217 2e-56
gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens] 216 4e-56
gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo ... 189 4e-48
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ... 189 4e-48
gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens] 185 1e-46
gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens] 185 1e-46
gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 176 4e-44
gi|28557781 protein kinase C, eta [Homo sapiens] 47 6e-05
gi|219842266 usherin isoform B [Homo sapiens] 35 0.18
gi|219842259 usherin isoform A [Homo sapiens] 35 0.18
gi|5453976 protein kinase C, theta [Homo sapiens] 35 0.24
gi|126723501 zinc finger protein (C2H2 type) 277 [Homo sapiens] 34 0.41
gi|164414431 netrin G1 isoform 1 [Homo sapiens] 33 0.54
gi|167621456 kinase suppressor of ras 2 [Homo sapiens] 33 0.91
gi|47157325 protein kinase C, delta [Homo sapiens] 32 1.2
gi|31377782 protein kinase C, delta [Homo sapiens] 32 1.2
>gi|4503313 diacylglycerol kinase epsilon [Homo sapiens]
Length = 567
Score = 1194 bits (3090), Expect = 0.0
Identities = 567/567 (100%), Positives = 567/567 (100%)
Query: 1 MEAERRPAPGSPSEGLFADGHLILWTLCSVLLPVFITFWCSLQRSRRQLHRRDIFRKSKH 60
MEAERRPAPGSPSEGLFADGHLILWTLCSVLLPVFITFWCSLQRSRRQLHRRDIFRKSKH
Sbjct: 1 MEAERRPAPGSPSEGLFADGHLILWTLCSVLLPVFITFWCSLQRSRRQLHRRDIFRKSKH 60
Query: 61 GWRDTDLFSQPTYCCVCAQHILQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKNDTKVL 120
GWRDTDLFSQPTYCCVCAQHILQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKNDTKVL
Sbjct: 61 GWRDTDLFSQPTYCCVCAQHILQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKNDTKVL 120
Query: 121 DAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKNEKCDFG 180
DAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKNEKCDFG
Sbjct: 121 DAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKNEKCDFG 180
Query: 181 EFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQWTPLIILANSRSGTNMGEGLLGEF 240
EFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQWTPLIILANSRSGTNMGEGLLGEF
Sbjct: 181 EFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQWTPLIILANSRSGTNMGEGLLGEF 240
Query: 241 RILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEK 300
RILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEK
Sbjct: 241 RILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEK 300
Query: 301 YIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYY 360
YIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYY
Sbjct: 301 YIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYY 360
Query: 361 NLRKPKEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQEC 420
NLRKPKEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQEC
Sbjct: 361 NLRKPKEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQEC 420
Query: 421 KDLNKKVELELDGERVALPSLEGIIVLNIGYWGGGCRLWEGMGDETYPLARHDDGLLEVV 480
KDLNKKVELELDGERVALPSLEGIIVLNIGYWGGGCRLWEGMGDETYPLARHDDGLLEVV
Sbjct: 421 KDLNKKVELELDGERVALPSLEGIIVLNIGYWGGGCRLWEGMGDETYPLARHDDGLLEVV 480
Query: 481 GVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHA 540
GVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHA
Sbjct: 481 GVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHA 540
Query: 541 MMLYFSGEQTDDDISSTSDQEDIKATE 567
MMLYFSGEQTDDDISSTSDQEDIKATE
Sbjct: 541 MMLYFSGEQTDDDISSTSDQEDIKATE 567
>gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens]
Length = 804
Score = 284 bits (727), Expect = 1e-76
Identities = 192/553 (34%), Positives = 270/553 (48%), Gaps = 83/553 (15%)
Query: 59 KHGWRDTDLFSQPTYCCVCAQHIL----QGAFCDCCGLRVDEGCLRKADKRFQCKEIMLK 114
+H WR F++P YC +C ++ QG C C V E C+ +A + K
Sbjct: 244 QHVWR-LKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSK 302
Query: 115 NDTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKN 174
+T D M H+W+ GN P + C C + C L C+WCQ T+H++C + LK
Sbjct: 303 RNT---DVMHHYWVEGNCP--TKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH-LKP 356
Query: 175 EKCDFGEFKNLIIPPSYLTSI-----------------NQMRKDKKTDYE---------- 207
E CD G K+ I+PP+ + + + ++K+K +
Sbjct: 357 E-CDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKM 415
Query: 208 -----VLASKLGKQWTP------LIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTP 256
V G Q TP L++ N +SG GE + +F+ LLNP QV+ ++
Sbjct: 416 QRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNG 475
Query: 257 PIKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDL 316
P+ L +P + RVL CGGDGTVGWVLD ++ + P VA+LPLGTGNDL
Sbjct: 476 PMPGLNFFRDVPDF--RVLACGGDGTVGWVLDCIEKANVGKH----PPVAILPLGTGNDL 529
Query: 317 SNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFTM-NNYFS 375
+ L WG GY GE + ++L+++ + I LDRWK +V P +++ NNYFS
Sbjct: 530 ARCLRWGGGYEGE-NLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFS 588
Query: 376 VGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGER 435
+G DA +A FH REK P F+SR+ NK Y +GT + CK L++ VE+E DG +
Sbjct: 589 IGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQ 648
Query: 436 VAL--PSLEGIIVLNIGYWGGGCRLW------------EGMGDE---------TYPLARH 472
+ L SLEGI +LNI GG LW E G + A
Sbjct: 649 IDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQ 708
Query: 473 D--DGLLEVVGVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPC 530
D D LLEVVG+ G+ QI L + R + +I +PMQ+DGEPW Q PC
Sbjct: 709 DLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPC 768
Query: 531 TVTITHKTHAMML 543
T+ ITHK A ML
Sbjct: 769 TIKITHKNQAPML 781
>gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 276 bits (706), Expect = 4e-74
Identities = 184/538 (34%), Positives = 261/538 (48%), Gaps = 75/538 (13%)
Query: 59 KHGWRDTDLFSQPTYCCVCAQHI---LQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKN 115
+H WR F +P YC +C I QG C+ C V + C KA C+
Sbjct: 205 QHMWRPKR-FPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKA---LPCEVSTYAK 260
Query: 116 DTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKNE 175
K + H W+RG C C+++ L C+WC +HD+C++
Sbjct: 261 SRKDIGVQSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQ--AVGH 317
Query: 176 KCDFGEFKNLIIPPSYL----TSINQMRKDKKTDY-----------EVLASKLGKQWTPL 220
+CD G ++ I+PPS + + RK+ KT E L PL
Sbjct: 318 ECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHPL 377
Query: 221 IILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGD 280
++ N +SG G+ +L +F+ +LNP QVF++ K P L+L +P +R+LVCGGD
Sbjct: 378 LVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP--DSRILVCGGD 435
Query: 281 GTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVM 340
GTVGW+L+ +D K +P VAVLPLGTGNDL+ L WG GY G+ +A++L+++
Sbjct: 436 GTVGWILETID----KANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLE 490
Query: 341 EADGIKLDRWKVQVTNKGYYNLRKPKEFTM-NNYFSVGPDALMALNFHAHREKAPSLFSS 399
+ + +DRW V+V + P F + NNYFS+G DA +A FH REK P F+S
Sbjct: 491 MSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNS 550
Query: 400 RILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALP--SLEGIIVLNIGYWGGGCR 457
R+ NK Y + T + + CK L + + +E+ G+ + L SLEGI VLNI GG
Sbjct: 551 RMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSN 610
Query: 458 LW--------------EGMGDETYPLARHD----------DGLLEVVGVYGSFHCAQIQV 493
LW + +G + D D LEVVG+ G+ QI
Sbjct: 611 LWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYT 670
Query: 494 KLANPFRIGQAHTVRLILKCS--------MMPMQVDGEPWAQGPCTVTITHKTHAMML 543
KL N R + KCS +PMQ+DGEPW Q PCT+ ITHK ML
Sbjct: 671 KLKN--------AGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
>gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 276 bits (706), Expect = 4e-74
Identities = 184/538 (34%), Positives = 261/538 (48%), Gaps = 75/538 (13%)
Query: 59 KHGWRDTDLFSQPTYCCVCAQHI---LQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKN 115
+H WR F +P YC +C I QG C+ C V + C KA C+
Sbjct: 205 QHMWRPKR-FPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKA---LPCEVSTYAK 260
Query: 116 DTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKNE 175
K + H W+RG C C+++ L C+WC +HD+C++
Sbjct: 261 SRKDIGVQSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQ--AVGH 317
Query: 176 KCDFGEFKNLIIPPSYL----TSINQMRKDKKTDY-----------EVLASKLGKQWTPL 220
+CD G ++ I+PPS + + RK+ KT E L PL
Sbjct: 318 ECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHPL 377
Query: 221 IILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGD 280
++ N +SG G+ +L +F+ +LNP QVF++ K P L+L +P +R+LVCGGD
Sbjct: 378 LVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP--DSRILVCGGD 435
Query: 281 GTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVM 340
GTVGW+L+ +D K +P VAVLPLGTGNDL+ L WG GY G+ +A++L+++
Sbjct: 436 GTVGWILETID----KANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLE 490
Query: 341 EADGIKLDRWKVQVTNKGYYNLRKPKEFTM-NNYFSVGPDALMALNFHAHREKAPSLFSS 399
+ + +DRW V+V + P F + NNYFS+G DA +A FH REK P F+S
Sbjct: 491 MSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNS 550
Query: 400 RILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALP--SLEGIIVLNIGYWGGGCR 457
R+ NK Y + T + + CK L + + +E+ G+ + L SLEGI VLNI GG
Sbjct: 551 RMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSN 610
Query: 458 LW--------------EGMGDETYPLARHD----------DGLLEVVGVYGSFHCAQIQV 493
LW + +G + D D LEVVG+ G+ QI
Sbjct: 611 LWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYT 670
Query: 494 KLANPFRIGQAHTVRLILKCS--------MMPMQVDGEPWAQGPCTVTITHKTHAMML 543
KL N R + KCS +PMQ+DGEPW Q PCT+ ITHK ML
Sbjct: 671 KLKN--------AGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
>gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 276 bits (706), Expect = 4e-74
Identities = 184/538 (34%), Positives = 261/538 (48%), Gaps = 75/538 (13%)
Query: 59 KHGWRDTDLFSQPTYCCVCAQHI---LQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKN 115
+H WR F +P YC +C I QG C+ C V + C KA C+
Sbjct: 205 QHMWRPKR-FPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKA---LPCEVSTYAK 260
Query: 116 DTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKNE 175
K + H W+RG C C+++ L C+WC +HD+C++
Sbjct: 261 SRKDIGVQSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQ--AVGH 317
Query: 176 KCDFGEFKNLIIPPSYL----TSINQMRKDKKTDY-----------EVLASKLGKQWTPL 220
+CD G ++ I+PPS + + RK+ KT E L PL
Sbjct: 318 ECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHPL 377
Query: 221 IILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGD 280
++ N +SG G+ +L +F+ +LNP QVF++ K P L+L +P +R+LVCGGD
Sbjct: 378 LVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP--DSRILVCGGD 435
Query: 281 GTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVM 340
GTVGW+L+ +D K +P VAVLPLGTGNDL+ L WG GY G+ +A++L+++
Sbjct: 436 GTVGWILETID----KANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLE 490
Query: 341 EADGIKLDRWKVQVTNKGYYNLRKPKEFTM-NNYFSVGPDALMALNFHAHREKAPSLFSS 399
+ + +DRW V+V + P F + NNYFS+G DA +A FH REK P F+S
Sbjct: 491 MSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNS 550
Query: 400 RILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALP--SLEGIIVLNIGYWGGGCR 457
R+ NK Y + T + + CK L + + +E+ G+ + L SLEGI VLNI GG
Sbjct: 551 RMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSN 610
Query: 458 LW--------------EGMGDETYPLARHD----------DGLLEVVGVYGSFHCAQIQV 493
LW + +G + D D LEVVG+ G+ QI
Sbjct: 611 LWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYT 670
Query: 494 KLANPFRIGQAHTVRLILKCS--------MMPMQVDGEPWAQGPCTVTITHKTHAMML 543
KL N R + KCS +PMQ+DGEPW Q PCT+ ITHK ML
Sbjct: 671 KLKN--------AGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
>gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 276 bits (706), Expect = 4e-74
Identities = 184/538 (34%), Positives = 261/538 (48%), Gaps = 75/538 (13%)
Query: 59 KHGWRDTDLFSQPTYCCVCAQHI---LQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKN 115
+H WR F +P YC +C I QG C+ C V + C KA C+
Sbjct: 205 QHMWRPKR-FPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKA---LPCEVSTYAK 260
Query: 116 DTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKNE 175
K + H W+RG C C+++ L C+WC +HD+C++
Sbjct: 261 SRKDIGVQSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQ--AVGH 317
Query: 176 KCDFGEFKNLIIPPSYL----TSINQMRKDKKTDY-----------EVLASKLGKQWTPL 220
+CD G ++ I+PPS + + RK+ KT E L PL
Sbjct: 318 ECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHPL 377
Query: 221 IILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGD 280
++ N +SG G+ +L +F+ +LNP QVF++ K P L+L +P +R+LVCGGD
Sbjct: 378 LVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP--DSRILVCGGD 435
Query: 281 GTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVM 340
GTVGW+L+ +D K +P VAVLPLGTGNDL+ L WG GY G+ +A++L+++
Sbjct: 436 GTVGWILETID----KANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLE 490
Query: 341 EADGIKLDRWKVQVTNKGYYNLRKPKEFTM-NNYFSVGPDALMALNFHAHREKAPSLFSS 399
+ + +DRW V+V + P F + NNYFS+G DA +A FH REK P F+S
Sbjct: 491 MSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNS 550
Query: 400 RILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALP--SLEGIIVLNIGYWGGGCR 457
R+ NK Y + T + + CK L + + +E+ G+ + L SLEGI VLNI GG
Sbjct: 551 RMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSN 610
Query: 458 LW--------------EGMGDETYPLARHD----------DGLLEVVGVYGSFHCAQIQV 493
LW + +G + D D LEVVG+ G+ QI
Sbjct: 611 LWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYT 670
Query: 494 KLANPFRIGQAHTVRLILKCS--------MMPMQVDGEPWAQGPCTVTITHKTHAMML 543
KL N R + KCS +PMQ+DGEPW Q PCT+ ITHK ML
Sbjct: 671 KLKN--------AGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML 720
>gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens]
Length = 791
Score = 274 bits (700), Expect = 2e-73
Identities = 189/521 (36%), Positives = 262/521 (50%), Gaps = 56/521 (10%)
Query: 59 KHGWRDTDLFSQPTYCCVCAQHIL------QGAFCDCCGLRVDEGCLRKADKRFQCKEIM 112
+H W F +PTYC C HI+ QG C C V E C+ +
Sbjct: 271 RHAWTMKH-FKKPTYCNFC--HIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSK 327
Query: 113 LKNDTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSL 172
K +V M H W+ GN + C C + C + C+WC+ T H +C ++L
Sbjct: 328 AKRSGEV---MQHAWVEGNSSV--KCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTL 382
Query: 173 KNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLAS-KLGKQWT--------PLIIL 223
CD GE ++ I+ P+ + I + R +K+D V A +L Q+ PL++L
Sbjct: 383 ----CDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVL 438
Query: 224 ANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTV 283
N +SG GE +L +F LLNP QVF++ P L P + RVL CGGDGTV
Sbjct: 439 VNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDF--RVLACGGDGTV 496
Query: 284 GWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEAD 343
GW+LD +D K P VAVLPLGTGNDL+ L WG GY G + ++L+++ ++
Sbjct: 497 GWILDCID----KANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGG-SLTKILKDIEQSP 551
Query: 344 GIKLDRWKVQVTNKGYYNLRKPKEFT-MNNYFSVGPDALMALNFHAHREKAPSLFSSRIL 402
+ LDRW ++V + ++ MNNYFS+G DA +A FH REK P F+SR+
Sbjct: 552 LVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMK 611
Query: 403 NKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALPS--LEGIIVLNIGYWGGGCRLW- 459
NK Y +GT + CK L+ +ELE DG V L + LEGI +LNI GG LW
Sbjct: 612 NKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWG 671
Query: 460 -------------EGMGDE---TYPLARHDDGLLEVVGVYGSFHCAQIQVKLANP-FRIG 502
+G+ D + + D LLEVVG+ G+ QI L + R+
Sbjct: 672 ENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLA 731
Query: 503 QAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMML 543
Q +V I ++PMQVDGEPW Q CT+ ITHK A M+
Sbjct: 732 QCASV-TIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMM 771
>gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens]
Length = 773
Score = 273 bits (697), Expect = 4e-73
Identities = 186/543 (34%), Positives = 264/543 (48%), Gaps = 83/543 (15%)
Query: 59 KHGWRDTDLFSQPTYCCVCAQHIL----QGAFCDCCGLRVDEGCLRKADKRFQCKEIMLK 114
+H WR F++P YC +C ++ QG C C V E C+ +A + K
Sbjct: 244 QHVWR-LKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSK 302
Query: 115 NDTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKN 174
+T D M H+W+ GN P + C C + C L C+WCQ T+H++C + LK
Sbjct: 303 RNT---DVMHHYWVEGNCP--TKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH-LKP 356
Query: 175 EKCDFGEFKNLIIPPSYLTSI-----------------NQMRKDKKTDYE---------- 207
E CD G K+ I+PP+ + + + ++K+K +
Sbjct: 357 E-CDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKM 415
Query: 208 -----VLASKLGKQWTP------LIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTP 256
V G Q TP L++ N +SG GE + +F+ LLNP QV+ ++
Sbjct: 416 QRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNG 475
Query: 257 PIKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDL 316
P+ L +P + RVL CGGDGTVGWVLD ++ + P VA+LPLGTGNDL
Sbjct: 476 PMPGLNFFRDVPDF--RVLACGGDGTVGWVLDCIEKANVGKH----PPVAILPLGTGNDL 529
Query: 317 SNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFTM-NNYFS 375
+ L WG GY GE + ++L+++ + I LDRWK +V P +++ NNYFS
Sbjct: 530 ARCLRWGGGYEGE-NLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFS 588
Query: 376 VGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGER 435
+G DA +A FH REK P F+SR+ NK Y +GT + CK L++ VE+E DG +
Sbjct: 589 IGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQ 648
Query: 436 VAL--PSLEGIIVLNIGYWGGGCRLW------------EGMGDE---------TYPLARH 472
+ L SLEGI +LNI GG LW E G + A
Sbjct: 649 IDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQ 708
Query: 473 D--DGLLEVVGVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPC 530
D D LLEVVG+ G+ QI L + R + +I +PMQ+DGEPW Q PC
Sbjct: 709 DLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPC 768
Query: 531 TVT 533
TV+
Sbjct: 769 TVS 771
>gi|40806175 diacylglycerol kinase, theta [Homo sapiens]
Length = 942
Score = 251 bits (640), Expect = 2e-66
Identities = 142/330 (43%), Positives = 194/330 (58%), Gaps = 14/330 (4%)
Query: 207 EVLASKLGKQWTPLIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTL 266
++L +KL PL++ N +SG G LL FR LLNP QVFD+T P+ L L +
Sbjct: 576 DLLHAKLPPDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQ 635
Query: 267 LPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGY 326
+P + RVLVCGGDGTVGWVL A+++ + + P VA+LPLGTGNDL L WG GY
Sbjct: 636 VPCF--RVLVCGGDGTVGWVLGALEETRYRLACPE-PSVAILPLGTGNDLGRVLRWGAGY 692
Query: 327 AGEIPVAQVLRNVMEADGIKLDRWKVQV-------TNKGYYNLRKPKEFTMNNYFSVGPD 379
+GE P + VL +V EAD + +DRW + + + PK M+NY +G D
Sbjct: 693 SGEDPFS-VLLSVDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGID 751
Query: 380 ALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALP 439
A ++L+FH RE+ P F+SR+ NK VY+ G + + + L+K++ L+++ + V LP
Sbjct: 752 AELSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELP 809
Query: 440 SLEGIIVLNIGYWGGGCRLWEGMGDETYPLARHDDGLLEVVGVYGSFHCAQIQVKLANPF 499
S+EG+I +NI WG G LW D + R DDGLLEVVGV G H Q+Q L +
Sbjct: 810 SIEGLIFINIPSWGSGADLWGSDSDTRFEKPRMDDGLLEVVGVTGVVHMGQVQGGLRSGI 869
Query: 500 RIGQAHTVRLILKCSMMPMQVDGEPWAQGP 529
RI Q R+ L P+QVDGEPW Q P
Sbjct: 870 RIAQGSYFRVTL-LKATPVQVDGEPWVQAP 898
Score = 66.2 bits (160), Expect = 7e-11
Identities = 35/119 (29%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 73 YCCVCAQHILQGAF-CDCCGLRVDEGCLRKADKRFQCKEIMLKNDTKVLDAMPHHWIRGN 131
+C VC + + A C+ C L + C+ A C++ ++ + D HHW GN
Sbjct: 134 FCAVCRKVLEAPALHCEVCELHLHPDCVPFACS--DCRQCH-QDGHQDHDTHHHHWREGN 190
Query: 132 VPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKNEKCDFGEFKNLIIPPS 190
+P + C VC++ CG L RC WC H C ++ +C FG ++L++PP+
Sbjct: 191 LPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLC--SAALAPECGFGRLRSLVLPPA 247
>gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens]
Length = 766
Score = 245 bits (626), Expect = 7e-65
Identities = 182/521 (34%), Positives = 250/521 (47%), Gaps = 81/521 (15%)
Query: 59 KHGWRDTDLFSQPTYCCVCAQHIL------QGAFCDCCGLRVDEGCLRKADKRFQCKEIM 112
+H W F +PTYC C HI+ QG C C V E C+ +
Sbjct: 271 RHAWTMKH-FKKPTYCNFC--HIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSK 327
Query: 113 LKNDTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSL 172
K +V M H W+ GN + C C + C + C+WC+ T H +C ++L
Sbjct: 328 AKRSGEV---MQHAWVEGNSSV--KCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTL 382
Query: 173 KNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLAS-KLGKQWT--------PLIIL 223
CD GE ++ I+ P+ + I + R +K+D V A +L Q+ PL++L
Sbjct: 383 ----CDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVL 438
Query: 224 ANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTV 283
N +SG GE L FR TP RVL CGGDGTV
Sbjct: 439 VNPKSGGRQGERL-NFFR------------DTPDF--------------RVLACGGDGTV 471
Query: 284 GWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEAD 343
GW+LD +D K P VAVLPLGTGNDL+ L WG GY G + ++L+++ ++
Sbjct: 472 GWILDCID----KANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGG-SLTKILKDIEQSP 526
Query: 344 GIKLDRWKVQVTNKGYYNLRKPKEFT-MNNYFSVGPDALMALNFHAHREKAPSLFSSRIL 402
+ LDRW ++V + ++ MNNYFS+G DA +A FH REK P F+SR+
Sbjct: 527 LVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMK 586
Query: 403 NKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALPS--LEGIIVLNIGYWGGGCRLW- 459
NK Y +GT + CK L+ +ELE DG V L + LEGI +LNI GG LW
Sbjct: 587 NKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWG 646
Query: 460 -------------EGMGDE---TYPLARHDDGLLEVVGVYGSFHCAQIQVKLANP-FRIG 502
+G+ D + + D LLEVVG+ G+ QI L + R+
Sbjct: 647 ENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLA 706
Query: 503 QAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMML 543
Q +V I ++PMQVDGEPW Q CT+ ITHK A M+
Sbjct: 707 QCASV-TIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMM 746
>gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens]
Length = 752
Score = 242 bits (617), Expect = 8e-64
Identities = 169/472 (35%), Positives = 238/472 (50%), Gaps = 64/472 (13%)
Query: 125 HHWIRGNVPLCSYCMVCK-QQCGCQPK-LCDYRCIWCQKTVHDECMKNSLK--------- 173
H W + +YC C G + + LC C +C+ TVH+ C+ ++
Sbjct: 272 HAWTMKHFKKPTYCNFCHIMLMGVRKQGLC---CTYCKYTVHERCVSRNIPGCVKTYSKA 328
Query: 174 ------------NEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLAS-KLGKQWT-- 218
+ CD GE ++ I+ P+ + I + R +K+D V A +L Q+
Sbjct: 329 KRSGEFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKII 388
Query: 219 ------PLIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSA 272
PL++L N +SG GE +L +F LLNP QVF++ P L P +
Sbjct: 389 PTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDF-- 446
Query: 273 RVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPV 332
RVL CGGDGTVGW+LD +D K P VAVLPLGTGNDL+ L WG GY G +
Sbjct: 447 RVLACGGDGTVGWILDCID----KANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGG-SL 501
Query: 333 AQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFT-MNNYFSVGPDALMALNFHAHRE 391
++L+++ ++ + LDRW ++V + ++ MNNYFS+G DA +A FH RE
Sbjct: 502 TKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMRE 561
Query: 392 KAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALPS--LEGIIVLNI 449
K P F+SR+ NK Y +GT + CK L+ +ELE DG V L + LEGI +LNI
Sbjct: 562 KHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNI 621
Query: 450 GYWGGGCRLW--------------EGMGDE---TYPLARHDDGLLEVVGVYGSFHCAQIQ 492
GG LW +G+ D + + D LLEVVG+ G+ QI
Sbjct: 622 PSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIY 681
Query: 493 VKLANP-FRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMML 543
L + R+ Q +V I ++PMQVDGEPW Q CT+ ITHK A M+
Sbjct: 682 TGLKSAGRRLAQCASV-TIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMM 732
>gi|4758156 diacylglycerol kinase, iota [Homo sapiens]
Length = 1065
Score = 231 bits (589), Expect = 1e-60
Identities = 175/567 (30%), Positives = 266/567 (46%), Gaps = 71/567 (12%)
Query: 59 KHGWRDTDLFSQPTYCCV--CAQHILQGAF---CDCCGLRVDEGCLRKADK-RFQCKEIM 112
+H W +T++ Y C + A C C + V C+ + +K F+CK
Sbjct: 177 EHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTF 236
Query: 113 LKNDTKVL--DAMPHHWI--RGNVPLCSYCMVCKQQCGC--QPKLCDYRCIWCQKTVHDE 166
+ ++ + + HHW+ R C C QQ ++ C WC++ H++
Sbjct: 237 REGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNK 296
Query: 167 --CMKNSLKNEKCDFGEFKNLIIPPSYLTSINQM--------RKDKKTDYEVLASKLGKQ 216
C E C G +I+PP+++ + + RK K+T ++ ASK G +
Sbjct: 297 VTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGME 356
Query: 217 -----------------WTPLIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIK 259
PL++ N +SG N G +L F LNP QVFD+++ P
Sbjct: 357 QENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKD 416
Query: 260 ALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNT 319
AL+L +P + R+L CGGDGTVGW+L +D++++ Q P V VLPLGTGNDL+ T
Sbjct: 417 ALELYRKVP--NLRILACGGDGTVGWILSILDELQLSPQ----PPVGVLPLGTGNDLART 470
Query: 320 LGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEF----------T 369
L WG GY E PV+++L V + ++LDRW + V P+E
Sbjct: 471 LNWGGGYTDE-PVSKILCQVEDGTVVQLDRWNLHVERNPDL---PPEELEDGVCKLPLNV 526
Query: 370 MNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVEL 429
NNYFS+G DA + L FH RE P F+SR NK Y D L + +DL+K V++
Sbjct: 527 FNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKV 586
Query: 430 ELDG----ERVALPSLEGIIVLNIGYWGGGCRLWEGMGD-ETYPLARHDDGLLEVVGVYG 484
DG ++ + I+ LNI + G W GD + RHDDG +EV+G +
Sbjct: 587 VCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIG-FT 645
Query: 485 SFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMMLY 544
A +QV + R+ Q V ++L +PMQVDGEP P + I+ + A M+
Sbjct: 646 MASLAALQVG-GHGERLHQCREV-MLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQ 703
Query: 545 FSGEQTD----DDISSTSDQEDIKATE 567
S +T +D S D+ I+ +
Sbjct: 704 KSKRRTSMPLLNDPQSVPDRLRIRVNK 730
>gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens]
Length = 945
Score = 217 bits (553), Expect = 2e-56
Identities = 180/611 (29%), Positives = 282/611 (46%), Gaps = 84/611 (13%)
Query: 2 EAERRPAPGSPSEGLFADGHL---------ILWTLCSVLLPVFITFWCSLQRSRRQLHRR 52
E R A G P E F HL I + L P T S RQ+
Sbjct: 44 EGSRGTAAGPPVEERFRQLHLRKQVSYRKAITKSGLQHLAPPPPTPGAPCSESERQIRST 103
Query: 53 DIFRKS----KHGWRDTDLFSQPTYCCV----CAQHILQGAF---CDCCGLRVDEGCLRK 101
+ +S +H W +T++ +C V C +L+ C C + V C+ +
Sbjct: 104 VDWSESATYGEHIWFETNVSGD--FCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQ 161
Query: 102 ADK-RFQCKEIMLKNDTKVLDA---MPHHWI--RGNVPLCSYCMVCKQQCGC--QPKLCD 153
+K F+CK ++ ++ + + HHW+ R C +C QQ ++
Sbjct: 162 LEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVA 221
Query: 154 YRCIWCQKTVHDE--CMKNSLKNEKCDFGEFKNLIIPPSYL-------TSINQMRKDKKT 204
C WC++ H + C E C G ++IPP+++ ++ +K K+
Sbjct: 222 ISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRA 281
Query: 205 DYEVLASKLGKQ---WTP-------------LIILANSRSGTNMGEGLLGEFRILLNPVQ 248
++ +SK G + W P L++ N +SG N G ++ F LNP Q
Sbjct: 282 SFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQ 341
Query: 249 VFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVL 308
VFD+++ P +AL++ + ++ R+L CGGDGTVGW+L +D +++K P VA+L
Sbjct: 342 VFDLSQGGPKEALEMYRKV--HNLRILACGGDGTVGWILSTLDQLRLKPP----PPVAIL 395
Query: 309 PLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVT----------NKG 358
PLGTGNDL+ TL WG GY E PV+++L +V E + ++LDRW + ++G
Sbjct: 396 PLGTGNDLARTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEG 454
Query: 359 YYNLRKPKEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQ 418
+ R P + NNYFS+G DA + L FH RE P F+SR NK Y D L+
Sbjct: 455 ATD-RLPLD-VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMG 512
Query: 419 ECKDLNKKVELELDGERVALPSLEG-----IIVLNIGYWGGGCRLWEGMGD-ETYPLARH 472
KDL K + + DG + P ++ ++ LNI + G W G+ + RH
Sbjct: 513 SSKDLAKHIRVVCDGMDLT-PKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRH 571
Query: 473 DDGLLEVVGVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTV 532
DDG LEV+G + A +QV + R+ Q V ++ +P+QVDGEP +
Sbjct: 572 DDGYLEVIG-FTMTSLAALQVG-GHGERLTQCREV-VLTTSKAIPVQVDGEPCKLAASRI 628
Query: 533 TITHKTHAMML 543
I + A M+
Sbjct: 629 RIALRNQATMV 639
>gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens]
Length = 929
Score = 217 bits (553), Expect = 2e-56
Identities = 164/542 (30%), Positives = 262/542 (48%), Gaps = 72/542 (13%)
Query: 59 KHGWRDTDLFSQPTYCCV----CAQHILQGAF----CDCCGLRVDEGCLRKADK-RFQCK 109
+H W +T++ +C V C +LQ + C C + V C+ + +K F+CK
Sbjct: 97 EHIWFETNVSGD--FCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCK 154
Query: 110 EIMLKNDTKVLDA---MPHHWI--RGNVPLCSYCMVCKQQCGC--QPKLCDYRCIWCQKT 162
++ ++ + + HHW+ R C +C QQ ++ C WC++
Sbjct: 155 PSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQA 214
Query: 163 VHDE--CMKNSLKNEKCDFGEFKNLIIPPSYL-------TSINQMRKDKKTDYEVLASKL 213
H + C E C G ++IPP+++ ++ +K K+ ++ +SK
Sbjct: 215 YHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKK 274
Query: 214 GKQ---WTP-------------LIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPP 257
G + W P L++ N +SG N G ++ F LNP QVFD+++ P
Sbjct: 275 GPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGP 334
Query: 258 IKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLS 317
+AL++ + ++ R+L CGGDGTVGW+L +D +++K P VA+LPLGTGNDL+
Sbjct: 335 KEALEMYRKV--HNLRILACGGDGTVGWILSTLDQLRLKPP----PPVAILPLGTGNDLA 388
Query: 318 NTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVT----------NKGYYNLRKPKE 367
TL WG GY E PV+++L +V E + ++LDRW + ++G + R P +
Sbjct: 389 RTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATD-RLPLD 446
Query: 368 FTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKV 427
NNYFS+G DA + L FH RE P F+SR NK Y D L+ KDL K +
Sbjct: 447 -VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHI 505
Query: 428 ELELDGERVALPSLEG-----IIVLNIGYWGGGCRLWEGMGD-ETYPLARHDDGLLEVVG 481
+ DG + P ++ ++ LNI + G W G+ + RHDDG LEV+G
Sbjct: 506 RVVCDGMDLT-PKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIG 564
Query: 482 VYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHAM 541
+ A +QV + R+ Q V ++ +P+QVDGEP + I + A
Sbjct: 565 -FTMTSLAALQVG-GHGERLTQCREV-VLTTSKAIPVQVDGEPCKLAASRIRIALRNQAT 621
Query: 542 ML 543
M+
Sbjct: 622 MV 623
>gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens]
Length = 895
Score = 217 bits (553), Expect = 2e-56
Identities = 164/542 (30%), Positives = 262/542 (48%), Gaps = 72/542 (13%)
Query: 59 KHGWRDTDLFSQPTYCCV----CAQHILQGAF----CDCCGLRVDEGCLRKADK-RFQCK 109
+H W +T++ +C V C +LQ + C C + V C+ + +K F+CK
Sbjct: 63 EHIWFETNVSGD--FCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCK 120
Query: 110 EIMLKNDTKVLDA---MPHHWI--RGNVPLCSYCMVCKQQCGC--QPKLCDYRCIWCQKT 162
++ ++ + + HHW+ R C +C QQ ++ C WC++
Sbjct: 121 PSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQA 180
Query: 163 VHDE--CMKNSLKNEKCDFGEFKNLIIPPSYL-------TSINQMRKDKKTDYEVLASKL 213
H + C E C G ++IPP+++ ++ +K K+ ++ +SK
Sbjct: 181 YHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKK 240
Query: 214 GKQ---WTP-------------LIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPP 257
G + W P L++ N +SG N G ++ F LNP QVFD+++ P
Sbjct: 241 GPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGP 300
Query: 258 IKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLS 317
+AL++ + ++ R+L CGGDGTVGW+L +D +++K P VA+LPLGTGNDL+
Sbjct: 301 KEALEMYRKV--HNLRILACGGDGTVGWILSTLDQLRLKPP----PPVAILPLGTGNDLA 354
Query: 318 NTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVT----------NKGYYNLRKPKE 367
TL WG GY E PV+++L +V E + ++LDRW + ++G + R P +
Sbjct: 355 RTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATD-RLPLD 412
Query: 368 FTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKV 427
NNYFS+G DA + L FH RE P F+SR NK Y D L+ KDL K +
Sbjct: 413 -VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHI 471
Query: 428 ELELDGERVALPSLEG-----IIVLNIGYWGGGCRLWEGMGD-ETYPLARHDDGLLEVVG 481
+ DG + P ++ ++ LNI + G W G+ + RHDDG LEV+G
Sbjct: 472 RVVCDGMDLT-PKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIG 530
Query: 482 VYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHAM 541
+ A +QV + R+ Q V ++ +P+QVDGEP + I + A
Sbjct: 531 -FTMTSLAALQVG-GHGERLTQCREV-VLTTSKAIPVQVDGEPCKLAASRIRIALRNQAT 587
Query: 542 ML 543
M+
Sbjct: 588 MV 589
>gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens]
Length = 1117
Score = 216 bits (550), Expect = 4e-56
Identities = 163/541 (30%), Positives = 261/541 (48%), Gaps = 71/541 (13%)
Query: 59 KHGWRDTDLFSQPTYCCV----CAQHILQGAF---CDCCGLRVDEGCLRKADK-RFQCKE 110
+H W +T++ +C V C +L+ C C + V C+ + +K F+CK
Sbjct: 286 EHIWFETNVSGD--FCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKP 343
Query: 111 IMLKNDTKVLDA---MPHHWI--RGNVPLCSYCMVCKQQCGC--QPKLCDYRCIWCQKTV 163
++ ++ + + HHW+ R C +C QQ ++ C WC++
Sbjct: 344 SFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAY 403
Query: 164 HDE--CMKNSLKNEKCDFGEFKNLIIPPSYL-------TSINQMRKDKKTDYEVLASKLG 214
H + C E C G ++IPP+++ ++ +K K+ ++ +SK G
Sbjct: 404 HSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKG 463
Query: 215 KQ---WTP-------------LIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPI 258
+ W P L++ N +SG N G ++ F LNP QVFD+++ P
Sbjct: 464 PEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPK 523
Query: 259 KALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSN 318
+AL++ + ++ R+L CGGDGTVGW+L +D +++K P VA+LPLGTGNDL+
Sbjct: 524 EALEMYRKV--HNLRILACGGDGTVGWILSTLDQLRLKPP----PPVAILPLGTGNDLAR 577
Query: 319 TLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVT----------NKGYYNLRKPKEF 368
TL WG GY E PV+++L +V E + ++LDRW + ++G + R P +
Sbjct: 578 TLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATD-RLPLD- 634
Query: 369 TMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVE 428
NNYFS+G DA + L FH RE P F+SR NK Y D L+ KDL K +
Sbjct: 635 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 694
Query: 429 LELDGERVALPSLEG-----IIVLNIGYWGGGCRLWEGMGD-ETYPLARHDDGLLEVVGV 482
+ DG + P ++ ++ LNI + G W G+ + RHDDG LEV+G
Sbjct: 695 VVCDGMDLT-PKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIG- 752
Query: 483 YGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMM 542
+ A +QV + R+ Q V ++ +P+QVDGEP + I + A M
Sbjct: 753 FTMTSLAALQVG-GHGERLTQCREV-VLTTSKAIPVQVDGEPCKLAASRIRIALRNQATM 810
Query: 543 L 543
+
Sbjct: 811 V 811
>gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo
sapiens]
Length = 1170
Score = 189 bits (481), Expect = 4e-48
Identities = 132/396 (33%), Positives = 191/396 (48%), Gaps = 41/396 (10%)
Query: 60 HGWRDTDLFSQPTYCCVCAQHIL----QGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKN 115
H W ++PTYC VC + + G C+ C + + C +A CK L +
Sbjct: 120 HNWYACS-HARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNN--CKWTTLAS 176
Query: 116 DTKVLD------AMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMK 169
K + AMPH W+ GN+P+ + C VC + CG +L D+RC+WC+ VH C +
Sbjct: 177 IGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKE 236
Query: 170 NSLKNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQWTPLIILANSRSG 229
+ L KC G K +IPP+ L SI+ +D AS +PL++ NS+SG
Sbjct: 237 SLL--TKCPLGLCKVSVIPPTALNSID-------SDGFWKASCPPSCTSPLLVFVNSKSG 287
Query: 230 TNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDA 289
N G L F+ LLNP QVFD+ P L+L + + R+LVCGGDG+VGWVL
Sbjct: 288 DNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRL--FQKFDTFRILVCGGDGSVGWVLSE 345
Query: 290 VDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDR 349
+D + + Q Q+ VLPLGTGNDL+ LGWG+ + + Q+L + A LDR
Sbjct: 346 IDSLNLHKQ----CQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDR 401
Query: 350 WKVQVTNKGYYNLRKPKE---FTMNNYFSVGPDALMALNFH----AHREK-APSLFSSRI 401
W V Y + P++ T+ FS + L + AH K S S +
Sbjct: 402 WSVMA-----YEAKLPRQASSSTVTEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVV 456
Query: 402 LNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVA 437
++ A L KD + + K K E + E +A
Sbjct: 457 ISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMA 492
Score = 133 bits (335), Expect = 4e-31
Identities = 84/221 (38%), Positives = 117/221 (52%), Gaps = 10/221 (4%)
Query: 325 GYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFTMNNYFSVGPDALMAL 384
G +G +P V+ ++ I D + + YY ++ MNNYF +G DA ++L
Sbjct: 683 GMSGSLPGGSVISRLL----INADPFNSEPETLEYYT----EKCVMNNYFGIGLDAKISL 734
Query: 385 NFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALPSLEGI 444
+F+ R++ P SR N Y GTK+ L + K+L +KV LE DG + LPSL+GI
Sbjct: 735 DFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIPLPSLQGI 794
Query: 445 IVLNIGYWGGGCRLWEG-MGDETYPLARHDDGLLEVVGVYGSFHCAQIQVKLANPFRIGQ 503
VLNI + GG W G D+T+ DD +LEVV V+GS A +V RI Q
Sbjct: 795 AVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQ 854
Query: 504 AHTVRL-ILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMML 543
TV++ IL +P+QVDGE W Q P + I HK A L
Sbjct: 855 CRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTL 895
>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
sapiens]
Length = 1214
Score = 189 bits (481), Expect = 4e-48
Identities = 132/396 (33%), Positives = 191/396 (48%), Gaps = 41/396 (10%)
Query: 60 HGWRDTDLFSQPTYCCVCAQHIL----QGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKN 115
H W ++PTYC VC + + G C+ C + + C +A CK L +
Sbjct: 164 HNWYACS-HARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNN--CKWTTLAS 220
Query: 116 DTKVLD------AMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMK 169
K + AMPH W+ GN+P+ + C VC + CG +L D+RC+WC+ VH C +
Sbjct: 221 IGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKE 280
Query: 170 NSLKNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQWTPLIILANSRSG 229
+ L KC G K +IPP+ L SI+ +D AS +PL++ NS+SG
Sbjct: 281 SLL--TKCPLGLCKVSVIPPTALNSID-------SDGFWKASCPPSCTSPLLVFVNSKSG 331
Query: 230 TNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDA 289
N G L F+ LLNP QVFD+ P L+L + + R+LVCGGDG+VGWVL
Sbjct: 332 DNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRL--FQKFDTFRILVCGGDGSVGWVLSE 389
Query: 290 VDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDR 349
+D + + Q Q+ VLPLGTGNDL+ LGWG+ + + Q+L + A LDR
Sbjct: 390 IDSLNLHKQ----CQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDR 445
Query: 350 WKVQVTNKGYYNLRKPKE---FTMNNYFSVGPDALMALNFH----AHREK-APSLFSSRI 401
W V Y + P++ T+ FS + L + AH K S S +
Sbjct: 446 WSVMA-----YEAKLPRQASSSTVTEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVV 500
Query: 402 LNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVA 437
++ A L KD + + K K E + E +A
Sbjct: 501 ISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMA 536
Score = 133 bits (335), Expect = 4e-31
Identities = 84/221 (38%), Positives = 117/221 (52%), Gaps = 10/221 (4%)
Query: 325 GYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFTMNNYFSVGPDALMAL 384
G +G +P V+ ++ I D + + YY ++ MNNYF +G DA ++L
Sbjct: 727 GMSGSLPGGSVISRLL----INADPFNSEPETLEYYT----EKCVMNNYFGIGLDAKISL 778
Query: 385 NFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALPSLEGI 444
+F+ R++ P SR N Y GTK+ L + K+L +KV LE DG + LPSL+GI
Sbjct: 779 DFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIPLPSLQGI 838
Query: 445 IVLNIGYWGGGCRLWEG-MGDETYPLARHDDGLLEVVGVYGSFHCAQIQVKLANPFRIGQ 503
VLNI + GG W G D+T+ DD +LEVV V+GS A +V RI Q
Sbjct: 839 AVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQ 898
Query: 504 AHTVRL-ILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMML 543
TV++ IL +P+QVDGE W Q P + I HK A L
Sbjct: 899 CRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTL 939
>gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]
Length = 1164
Score = 185 bits (469), Expect = 1e-46
Identities = 138/431 (32%), Positives = 196/431 (45%), Gaps = 71/431 (16%)
Query: 60 HGWRDTDLFSQPTYCCVCAQHIL----QGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKN 115
H W ++PT+C VC + + G C+ C + + C +A CK L +
Sbjct: 176 HNWYACS-HARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNN--CKWTTLAS 232
Query: 116 DTKVLD------AMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMK 169
K + AMPH W+ GN+P+ + C VC + CG +L D++C+WC+ VH C
Sbjct: 233 IGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTAC-- 290
Query: 170 NSLKNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQWTPLIILANSRSG 229
L + C G+ K IIPP L S + + T + S PL++ NS+SG
Sbjct: 291 KDLYHPICPLGQCKVSIIPPIALNSTDSDGFCRAT-FSFCVS-------PLLVFVNSKSG 342
Query: 230 TNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDA 289
N G L F+ LLNP QVFD+ P L+L + + R+LVCGGDG+VGWVL
Sbjct: 343 DNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRL--FQKFDNFRILVCGGDGSVGWVLSE 400
Query: 290 VDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDR 349
+D + + Q Q+ VLPLGTGNDL+ LGWG Y + + Q+L + A LDR
Sbjct: 401 IDKLNLNKQ----CQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDR 456
Query: 350 WKVQVTNKGYYNLRKP-------------KEFTMNNY-FSVGPDALMALNFHAHREKAPS 395
W + Y L+ P +EF M Y SV LN H A
Sbjct: 457 WSIMT-----YELKLPPKASLLPGPPEASEEFYMTIYEDSVATHLTKILNSDEH---AVV 508
Query: 396 LFSSRILNKAVYLFYG--------------TKDCLVQECKDLNKKVE-----LELDGERV 436
+ S++ L + V F D + +C LN+K+E L D +
Sbjct: 509 ISSAKTLCETVKDFVAKVEKTYDKTLENAVVADAVASKCSVLNEKLEQLLQALHTDSQAA 568
Query: 437 -ALPSLEGIIV 446
LP L +IV
Sbjct: 569 PVLPGLSPLIV 579
Score = 126 bits (317), Expect = 5e-29
Identities = 72/176 (40%), Positives = 99/176 (56%), Gaps = 2/176 (1%)
Query: 370 MNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVEL 429
MNNYF +G DA ++L F+ RE+ P SR N Y GT++ L + K+L ++V+L
Sbjct: 771 MNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQL 830
Query: 430 ELDGERVALPSLEGIIVLNIGYWGGGCRLWEG-MGDETYPLARHDDGLLEVVGVYGSFHC 488
E DG+ + LPSL+GI VLNI + GG W G D+ + DD +LEVV ++ S
Sbjct: 831 ECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQM 890
Query: 489 AQIQVKLANPFRIGQAHTVRL-ILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMML 543
A +V RI Q TV++ I +P+QVDGE W Q P + I HK A ML
Sbjct: 891 AVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQML 946
>gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]
Length = 1220
Score = 185 bits (469), Expect = 1e-46
Identities = 138/431 (32%), Positives = 196/431 (45%), Gaps = 71/431 (16%)
Query: 60 HGWRDTDLFSQPTYCCVCAQHIL----QGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKN 115
H W ++PT+C VC + + G C+ C + + C +A CK L +
Sbjct: 176 HNWYACS-HARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNN--CKWTTLAS 232
Query: 116 DTKVLD------AMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMK 169
K + AMPH W+ GN+P+ + C VC + CG +L D++C+WC+ VH C
Sbjct: 233 IGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTAC-- 290
Query: 170 NSLKNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQWTPLIILANSRSG 229
L + C G+ K IIPP L S + + T + S PL++ NS+SG
Sbjct: 291 KDLYHPICPLGQCKVSIIPPIALNSTDSDGFCRAT-FSFCVS-------PLLVFVNSKSG 342
Query: 230 TNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDA 289
N G L F+ LLNP QVFD+ P L+L + + R+LVCGGDG+VGWVL
Sbjct: 343 DNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRL--FQKFDNFRILVCGGDGSVGWVLSE 400
Query: 290 VDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDR 349
+D + + Q Q+ VLPLGTGNDL+ LGWG Y + + Q+L + A LDR
Sbjct: 401 IDKLNLNKQ----CQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDR 456
Query: 350 WKVQVTNKGYYNLRKP-------------KEFTMNNY-FSVGPDALMALNFHAHREKAPS 395
W + Y L+ P +EF M Y SV LN H A
Sbjct: 457 WSIMT-----YELKLPPKASLLPGPPEASEEFYMTIYEDSVATHLTKILNSDEH---AVV 508
Query: 396 LFSSRILNKAVYLFYG--------------TKDCLVQECKDLNKKVE-----LELDGERV 436
+ S++ L + V F D + +C LN+K+E L D +
Sbjct: 509 ISSAKTLCETVKDFVAKVEKTYDKTLENAVVADAVASKCSVLNEKLEQLLQALHTDSQAA 568
Query: 437 -ALPSLEGIIV 446
LP L +IV
Sbjct: 569 PVLPGLSPLIV 579
Score = 126 bits (317), Expect = 5e-29
Identities = 72/176 (40%), Positives = 99/176 (56%), Gaps = 2/176 (1%)
Query: 370 MNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVEL 429
MNNYF +G DA ++L F+ RE+ P SR N Y GT++ L + K+L ++V+L
Sbjct: 771 MNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQL 830
Query: 430 ELDGERVALPSLEGIIVLNIGYWGGGCRLWEG-MGDETYPLARHDDGLLEVVGVYGSFHC 488
E DG+ + LPSL+GI VLNI + GG W G D+ + DD +LEVV ++ S
Sbjct: 831 ECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQM 890
Query: 489 AQIQVKLANPFRIGQAHTVRL-ILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMML 543
A +V RI Q TV++ I +P+QVDGE W Q P + I HK A ML
Sbjct: 891 AVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQML 946
>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
Length = 1271
Score = 176 bits (447), Expect = 4e-44
Identities = 111/316 (35%), Positives = 162/316 (51%), Gaps = 34/316 (10%)
Query: 55 FRKSKHGWRDTDLFSQPT-YCCVCAQHI----LQGAFCDCCGLRVDEGCLRKADKRFQCK 109
F H W + +S T +C VC + I C+ C ++ C +A K +
Sbjct: 323 FLVGMHCWYSS--YSHRTQHCNVCRESIPALSRDAIICEVCKVKSHRLCALRASKDCKWN 380
Query: 110 EIMLKNDTKVLDA----MPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHD 165
+ + +D +L A MPH W+ GN+P+ S C VC + CG +L D+RC+WC TVHD
Sbjct: 381 TLSITDDL-LLPADEVNMPHQWVEGNMPVSSQCAVCHESCGSYQRLQDFRCLWCNSTVHD 439
Query: 166 ECMKNSLKNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLASK--LGKQWT----- 218
+C + K +C F ++ +IPP+ L+ D K D +++ S W+
Sbjct: 440 DCRRRFSK--ECCFRSHRSSVIPPTALS-------DPKGDGQLVVSSDFWNLDWSSACSC 490
Query: 219 PLIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCG 278
PL+I NS+SG + G L +F+ LNP QVFD+ K P L + + R+LVCG
Sbjct: 491 PLLIFINSKSGDHQGIVFLRKFKQYLNPSQVFDLLKGGPEAGLSM--FKNFARFRILVCG 548
Query: 279 GDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRN 338
GDG+V WVL +D + EK Q+AV+PLGTGNDL+ LGWG + +L
Sbjct: 549 GDGSVSWVLSLIDAFGL--HEKC--QLAVIPLGTGNDLARVLGWGAFWNKSKSPLDILNR 604
Query: 339 VMEADGIKLDRWKVQV 354
V +A LDRW V +
Sbjct: 605 VEQASVRILDRWSVMI 620
Score = 133 bits (335), Expect = 4e-31
Identities = 76/209 (36%), Positives = 115/209 (55%), Gaps = 7/209 (3%)
Query: 361 NLRKPKEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQEC 420
++R ++ MNNYF +G DA ++L+F+ R++ P ++SR+ NK Y GTK+ L +
Sbjct: 849 SIRFKEKCVMNNYFGIGLDAKISLDFNTRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSY 908
Query: 421 KDLNKKVELELDGERVALPSLEGIIVLNIGYWGGGCRLW-EGMGDETYPLARHDDGLLEV 479
+ L ++V LE DGE ++LP+L+GI+VLNI + GG W Y DDG LEV
Sbjct: 909 RKLEERVHLECDGETISLPNLQGIVVLNITSYAGGINFWGSNTATTEYEAPAIDDGKLEV 968
Query: 480 VGVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSM-MPMQVDGEPWAQGPCTVTITHKT 538
V ++GS A ++ + RI Q H V + + +P+QVDGE W Q P + I +K
Sbjct: 969 VAIFGSVQMAMSRIINLHHHRIAQCHEVMITIDGEEGIPVQVDGEAWIQRPGLIKIRYKN 1028
Query: 539 HAMMLYFSGEQTDDDISSTSDQEDIKATE 567
A ML D D ++ + K TE
Sbjct: 1029 AAQML-----TRDRDFENSMKMWEYKHTE 1052
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 46.6 bits (109), Expect = 6e-05
Identities = 48/179 (26%), Positives = 74/179 (41%), Gaps = 20/179 (11%)
Query: 44 RSRRQLHRRDIFRKSKHGWRDTDLFSQPTYCCVCAQHI-----LQGAFCDCCGLRVDEGC 98
R R++ RR + + + H + T L QPTYC C + I QG C C V + C
Sbjct: 156 RKRQRAMRRRVHQINGHKFMATYL-RQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRC 214
Query: 99 LRKADKRFQCKEIMLKNDTKVLDA-----MPHHWIRGNVPLCSYCMVCK------QQCGC 147
C+ + K D+K+ + +PH + N + ++C C + G
Sbjct: 215 HHLIVTACTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGL 274
Query: 148 QPKLCDYRC-IWCQKTVHDECMKNSLKNEK--CDFGEFKNLIIPPSYLTSINQMRKDKK 203
Q K+C I CQ V C N+++ K G I P S L S + +R+ K
Sbjct: 275 QCKICKMNVHIRCQANVAPNCGVNAVELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGK 333
>gi|219842266 usherin isoform B [Homo sapiens]
Length = 5202
Score = 35.0 bits (79), Expect = 0.18
Identities = 33/117 (28%), Positives = 46/117 (39%), Gaps = 24/117 (20%)
Query: 60 HGWRDT-DLFSQPTYCCVCAQH-ILQGAFCDCCGLRVDEGCLRKADK--RFQCKEIMLKN 115
HG D D SQP Y C+C+Q +G CD C ++ R+ D+ F CK +
Sbjct: 521 HGHADNCDTTSQP-YRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNS 579
Query: 116 DTK------VLDAMPHHWIRGNVPLCS---------YCMVCK----QQCGCQPKLCD 153
+K +D P RG +C C +CK +Q G P D
Sbjct: 580 HSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAID 636
>gi|219842259 usherin isoform A [Homo sapiens]
Length = 1546
Score = 35.0 bits (79), Expect = 0.18
Identities = 33/117 (28%), Positives = 46/117 (39%), Gaps = 24/117 (20%)
Query: 60 HGWRDT-DLFSQPTYCCVCAQH-ILQGAFCDCCGLRVDEGCLRKADK--RFQCKEIMLKN 115
HG D D SQP Y C+C+Q +G CD C ++ R+ D+ F CK +
Sbjct: 521 HGHADNCDTTSQP-YRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNS 579
Query: 116 DTK------VLDAMPHHWIRGNVPLCS---------YCMVCK----QQCGCQPKLCD 153
+K +D P RG +C C +CK +Q G P D
Sbjct: 580 HSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAID 636
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 34.7 bits (78), Expect = 0.24
Identities = 31/136 (22%), Positives = 51/136 (37%), Gaps = 12/136 (8%)
Query: 41 SLQRSRRQLHRRDIFRKSKHGWRDTDLFSQPTYCCVCAQHI----LQGAFCDCCGLRVDE 96
+L + R + + + H + T F QPT+C VC + + QG C C + +
Sbjct: 141 ALHQRRGAIKQAKVHHVKCHEFTAT-FFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHK 199
Query: 97 GCLRK-----ADKRFQCKEIMLKNDTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKL 151
C+ K +E M + +D MPH + N ++C C +
Sbjct: 200 KCIDKVIAKCTGSAINSRETMFHKERFKID-MPHRFKVYNYKSPTFCEHCGTLLWGLARQ 258
Query: 152 CDYRCIWCQKTVHDEC 167
+C C VH C
Sbjct: 259 -GLKCDACGMNVHHRC 273
>gi|126723501 zinc finger protein (C2H2 type) 277 [Homo sapiens]
Length = 450
Score = 33.9 bits (76), Expect = 0.41
Identities = 29/111 (26%), Positives = 47/111 (42%), Gaps = 16/111 (14%)
Query: 108 CKEIMLKNDTKVLDAMPHHWIRGNVPLCSYCMVCKQ-QCGCQPKLCDYRCIWCQKTVHDE 166
C E L N + +L+ M N+ L + C + C Q KL + +C++C+KT D
Sbjct: 178 CNEEFLGNRSVILNHMAREHAF-NIGLPDNIVNCNEFLCTLQKKLDNLQCLYCEKTFRD- 235
Query: 167 CMKNSLKNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQW 217
KN+LK+ + IN ++ Y + +LGK W
Sbjct: 236 --KNTLKDH-----------MRKKQHRKINPKNREYDRFYVINYLELGKSW 273
>gi|164414431 netrin G1 isoform 1 [Homo sapiens]
Length = 539
Score = 33.5 bits (75), Expect = 0.54
Identities = 25/100 (25%), Positives = 39/100 (39%), Gaps = 16/100 (16%)
Query: 72 TYCCVCAQHILQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKNDTKVLDAMPHHWIRGN 131
T CV +H +G C+ C L G R A + + + ++ L ++ H G+
Sbjct: 381 TVICVSCKHNTRGQHCELCRL----GYFRNASAQLDDENVCIECYCNPLGSI-HDRCNGS 435
Query: 132 V----------PLCSYCMVCKQ-QCGCQPKLCDYRCIWCQ 160
P C C+ GCQP +CD + CQ
Sbjct: 436 GFCECKTGTTGPKCDECLPGNSWHYGCQPNVCDNELLHCQ 475
>gi|167621456 kinase suppressor of ras 2 [Homo sapiens]
Length = 921
Score = 32.7 bits (73), Expect = 0.91
Identities = 20/62 (32%), Positives = 29/62 (46%), Gaps = 2/62 (3%)
Query: 41 SLQRSRRQLHRRDIFRKSKHGWRDTDLFSQPTYCCVCAQHILQGAFCDCCGLRVDEGCLR 100
S+ R Q+ RRD+ KH + SQ C VC + +L G C C L+ C +
Sbjct: 365 SVPRWSPQIPRRDLGNSIKHRFSTKYWMSQT--CTVCGKGMLFGLKCKNCKLKCHNKCTK 422
Query: 101 KA 102
+A
Sbjct: 423 EA 424
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 32.3 bits (72), Expect = 1.2
Identities = 27/109 (24%), Positives = 43/109 (39%), Gaps = 11/109 (10%)
Query: 68 FSQPTYCCVCAQHI----LQGAFCDCCGLRVDEGCLRKADKR-----FQCKEIMLKNDTK 118
F QPT+C VC + QG C C + + C+ K R ++ + + +
Sbjct: 166 FGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERF 225
Query: 119 VLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDEC 167
+D MPH + N ++C C K +C C VH +C
Sbjct: 226 NID-MPHRFKVHNYMSPTFCDHCGSLLWGLVKQ-GLKCEDCGMNVHHKC 272
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 32.3 bits (72), Expect = 1.2
Identities = 27/109 (24%), Positives = 43/109 (39%), Gaps = 11/109 (10%)
Query: 68 FSQPTYCCVCAQHI----LQGAFCDCCGLRVDEGCLRKADKR-----FQCKEIMLKNDTK 118
F QPT+C VC + QG C C + + C+ K R ++ + + +
Sbjct: 166 FGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERF 225
Query: 119 VLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDEC 167
+D MPH + N ++C C K +C C VH +C
Sbjct: 226 NID-MPHRFKVHNYMSPTFCDHCGSLLWGLVKQ-GLKCEDCGMNVHHKC 272
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.450
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,365,284
Number of Sequences: 37866
Number of extensions: 1075924
Number of successful extensions: 2348
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 2144
Number of HSP's gapped (non-prelim): 61
length of query: 567
length of database: 18,247,518
effective HSP length: 108
effective length of query: 459
effective length of database: 14,157,990
effective search space: 6498517410
effective search space used: 6498517410
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.