Search of human proteins with 42542394

Search of human proteins with 42542394

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|42542394 lysophosphatidylcholine acyltransferase 3 [Homo
sapiens]
         (487 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|42542394 lysophosphatidylcholine acyltransferase 3 [Homo sapi...   998   0.0  
gi|40548387 O-acyltransferase (membrane bound) domain containing...   137   3e-32
gi|122937404 membrane bound O-acyltransferase domain containing ...   122   7e-28
gi|225703079 membrane bound O-acyltransferase domain containing ...    82   1e-15
gi|225703081 membrane bound O-acyltransferase domain containing ...    71   2e-12
gi|225703033 membrane bound O-acyltransferase domain containing ...    71   2e-12
gi|45439337 porcupine isoform E [Homo sapiens]                         60   4e-09
gi|45439331 porcupine isoform B [Homo sapiens]                         60   4e-09
gi|45439329 porcupine isoform A [Homo sapiens]                         60   4e-09
gi|225703037 membrane bound O-acyltransferase domain containing ...    59   8e-09
gi|45439333 porcupine isoform C [Homo sapiens]                         57   3e-08
gi|45439335 porcupine isoform D [Homo sapiens]                         55   1e-07
gi|189571629 membrane bound O-acyltransferase domain containing ...    48   2e-05
gi|31083053 ceroid-lipofuscinosis, neuronal 8 [Homo sapiens]           30   3.8  
gi|170784861 hedgehog acyltransferase [Homo sapiens]                   30   3.8  
gi|170784863 hedgehog acyltransferase [Homo sapiens]                   30   3.8  
gi|169217968 PREDICTED: similar to solute carrier family 16, mem...    30   6.5  
gi|4885505 N-acetylated alpha-linked acidic dipeptidase 2 [Homo ...    30   6.5  
gi|4759116 solute carrier family 16, member 5 [Homo sapiens]           30   6.5  

>gi|42542394 lysophosphatidylcholine acyltransferase 3 [Homo
           sapiens]
          Length = 487

 Score =  998 bits (2580), Expect = 0.0
 Identities = 487/487 (100%), Positives = 487/487 (100%)

Query: 1   MASSAEGDEGTVVALAGVLQSGFQELSLNKLATSLGASEQALRLIISIFLGYPFALFYRH 60
           MASSAEGDEGTVVALAGVLQSGFQELSLNKLATSLGASEQALRLIISIFLGYPFALFYRH
Sbjct: 1   MASSAEGDEGTVVALAGVLQSGFQELSLNKLATSLGASEQALRLIISIFLGYPFALFYRH 60

Query: 61  YLFYKETYLIHLFHTFTGLSIAYFNFGNQLYHSLLCIVLQFLILRLMGRTITAVLTTFCF 120
           YLFYKETYLIHLFHTFTGLSIAYFNFGNQLYHSLLCIVLQFLILRLMGRTITAVLTTFCF
Sbjct: 61  YLFYKETYLIHLFHTFTGLSIAYFNFGNQLYHSLLCIVLQFLILRLMGRTITAVLTTFCF 120

Query: 121 QMAYLLAGYYYTATGNYDIKWTMPHCVLTLKLIGLAVDYFDGGKDQNSLSSEQQKYAIRG 180
           QMAYLLAGYYYTATGNYDIKWTMPHCVLTLKLIGLAVDYFDGGKDQNSLSSEQQKYAIRG
Sbjct: 121 QMAYLLAGYYYTATGNYDIKWTMPHCVLTLKLIGLAVDYFDGGKDQNSLSSEQQKYAIRG 180

Query: 181 VPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVQGELIDIPGKIPNSIIPALKRLSLGLFY 240
           VPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVQGELIDIPGKIPNSIIPALKRLSLGLFY
Sbjct: 181 VPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVQGELIDIPGKIPNSIIPALKRLSLGLFY 240

Query: 241 LVGYTLLSPHITEDYLLTEDYDNHPFWFRCMYMLIWGKFVLYKYVTCWLVTEGVCILTGL 300
           LVGYTLLSPHITEDYLLTEDYDNHPFWFRCMYMLIWGKFVLYKYVTCWLVTEGVCILTGL
Sbjct: 241 LVGYTLLSPHITEDYLLTEDYDNHPFWFRCMYMLIWGKFVLYKYVTCWLVTEGVCILTGL 300

Query: 301 GFNGFEEKGKAKWDACANMKVWLFETNPRFTGTIASFNINTNAWVARYIFKRLKFLGNKE 360
           GFNGFEEKGKAKWDACANMKVWLFETNPRFTGTIASFNINTNAWVARYIFKRLKFLGNKE
Sbjct: 301 GFNGFEEKGKAKWDACANMKVWLFETNPRFTGTIASFNINTNAWVARYIFKRLKFLGNKE 360

Query: 361 LSQGLSLLFLALWHGLHSGYLVCFQMEFLIVIVERQAARLIQESPTLSKLAAITVLQPFY 420
           LSQGLSLLFLALWHGLHSGYLVCFQMEFLIVIVERQAARLIQESPTLSKLAAITVLQPFY
Sbjct: 361 LSQGLSLLFLALWHGLHSGYLVCFQMEFLIVIVERQAARLIQESPTLSKLAAITVLQPFY 420

Query: 421 YLVQQTIHWLFMGYSMTAFCLFTWDKWLKVYKSIYFLGHIFFLSLLFILPYIHKAMVPRK 480
           YLVQQTIHWLFMGYSMTAFCLFTWDKWLKVYKSIYFLGHIFFLSLLFILPYIHKAMVPRK
Sbjct: 421 YLVQQTIHWLFMGYSMTAFCLFTWDKWLKVYKSIYFLGHIFFLSLLFILPYIHKAMVPRK 480

Query: 481 EKLKKME 487
           EKLKKME
Sbjct: 481 EKLKKME 487


>gi|40548387 O-acyltransferase (membrane bound) domain containing 2
           [Homo sapiens]
          Length = 520

 Score =  137 bits (344), Expect = 3e-32
 Identities = 112/444 (25%), Positives = 197/444 (44%), Gaps = 46/444 (10%)

Query: 55  ALFYRHYLFYKET--YLIHLFHTFTGLSIAYFNFGNQLYHSLLCIVLQFLILRLMGRTIT 112
           A+++R YL   +T  ++ H+  T  GL +A F FG    H L+   + + I+ ++G    
Sbjct: 39  AIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIG---V 95

Query: 113 AVLTTFCFQMA--YL----LAGYYYTATGNYDIKWTMPHCVLTLKLIGLAVDYFDGG-KD 165
             +  +CF  A  YL    +   Y    G Y   ++ P  ++T K+  LA +  DG  + 
Sbjct: 96  ENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRK 155

Query: 166 QNSLSSEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVQGELIDIP----- 220
              L+S Q+  A+R +PSLLE   ++  +   L GP  S   Y+  ++G    I      
Sbjct: 156 DEELTSSQRDLAVRRMPSLLEYLSYNCNFMGILAGPLCSYKDYITFIEGRSYHITQSGEN 215

Query: 221 GK----------IPNSIIPALKRLSLGLFYLVGYTLLSPHITEDYLLTEDYDNHPFW-FR 269
           GK           PN+ +   K L  GL  L   T+ +  +  +Y + E +     W  +
Sbjct: 216 GKEETQYERTEPSPNTAV-VQKLLVCGLSLLFHLTICTT-LPVEYNIDEHFQATASWPTK 273

Query: 270 CMYMLIWGKFVLYKYVTCWLVTEGVCILTGLGFNGFEEKGKAKWDACANMKVWLFETNPR 329
            +Y+ I       KY   W + + +    G GF G++E G A+WD  +N+++   E +  
Sbjct: 274 IIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTS 333

Query: 330 FTGTIASFNINTNAWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLVCFQMEFL 389
           F   + ++NI T  W+ R  ++R  F    +     + +  A+WHG++ GY + F    L
Sbjct: 334 FKMFLDNWNIQTALWLKRVCYERTSFSPTIQ-----TFILSAIWHGVYPGYYLTFLTGVL 388

Query: 390 IVIVERQAARLIQE---SPTLSKLAAITVLQPFYYLVQQTIHWLFMGYSMTAFCLFTWDK 446
           + +  R      +     P+  KL        FY ++   +  + + Y++  F L +   
Sbjct: 389 MTLAARAMRNNFRHYFIEPSQLKL--------FYDVITWIVTQVAISYTVVPFVLLSIKP 440

Query: 447 WLKVYKSIYFLGHIFFLSLLFILP 470
            L  Y S Y+  HI  + +L +LP
Sbjct: 441 SLTFYSSWYYCLHILGILVLLLLP 464


>gi|122937404 membrane bound O-acyltransferase domain containing 1
           [Homo sapiens]
          Length = 495

 Score =  122 bits (306), Expect = 7e-28
 Identities = 115/482 (23%), Positives = 204/482 (42%), Gaps = 48/482 (9%)

Query: 28  LNKLATSLGASEQALRLIISIFLGYPFALFYRHYLFYKETY--LIHLFHTFTGLSIAYFN 85
           L+ L+  LG     +  ++   +    A ++R YL    T   + H   T  G+    F 
Sbjct: 20  LHPLSELLGIPLDQVNFVVCQLVALFAAFWFRIYLRPGTTSSDVRHAVATIFGIYFVIFC 79

Query: 86  FGNQLYHSLLCIVLQFLILRLMGRTITAVLT-----TFCFQMAYL----LAGYYYTATGN 136
           FG    H  + +++ + I+      +TA ++     +F   M YL    ++  Y    G 
Sbjct: 80  FGWYSVHLFVLVLMCYAIM------VTASVSNIHRYSFFVAMGYLTICHISRIYIFHYGI 133

Query: 137 YDIKWTMPHCVLTLKLIGLAVDYFDG-GKDQNSLSSEQQKYAIRGVPSLLEVAGFSYFYG 195
               ++ P  ++T K+  LA    DG G+    LS+EQ + AI+  PS LE   +   + 
Sbjct: 134 LTTDFSGPLMIVTQKITTLAFQVHDGLGRRAEDLSAEQHRLAIKVKPSFLEYLSYLLNFM 193

Query: 196 AFLVGPQFSMNHYMKLVQGELI---------------DIPGKIPNSIIPALKRLSLGLFY 240
           + + GP  +   Y+  ++G+ I                +P   P   +  + +L + L  
Sbjct: 194 SVIAGPCNNFKDYIAFIEGKHIHMKLLEVNWKRKGFHSLPEPSPTGAV--IHKLGITLVS 251

Query: 241 LVGYTLLSPHITEDYLLTEDYDNHPFWF--RCMYMLIWGKFVLYKYVTCWLVTEGVCILT 298
           L+ +  L+       L+ +D+  H   F  R  Y+ +  +    KY   W + + V    
Sbjct: 252 LLLFLTLTKTFPVTCLV-DDWFVHKASFPARLCYLYVVMQASKPKYYFAWTLADAVNNAA 310

Query: 299 GLGFNGFEEKGKAKWDACANMKVWLFETNPRFTGTIASFNINTNAWVARYIFKRLKFLGN 358
           G GF+G ++ G   WD  +N+ +W  ET   F   + ++NI T  W+    ++R+ +   
Sbjct: 311 GFGFSGVDKNGNFCWDLLSNLNIWKIETATSFKMYLENWNIQTATWLKCVCYQRVPWYPT 370

Query: 359 KELSQGLSLLFLALWHGLHSGYLVCFQMEFLIVIVERQAARLIQESPTLSKLAAITVLQP 418
                 L+ +  ALWHG++ GY   F    L+ +  R A R       LS  A   V   
Sbjct: 371 V-----LTFILSALWHGVYPGYYFTFLTGILVTLAAR-AVRNNYRHYFLSSRALKAVYDA 424

Query: 419 FYYLVQQTIHWLFMGYSMTAFCLFTWDKWLKVYKSIYFLGHIFFLSLLFILPYIHKAMVP 478
             + V Q    L + Y++  F +   +  + +YKS+YF  HI  L ++  LP   +A   
Sbjct: 425 GTWAVTQ----LAVSYTVAPFVMLAVEPTISLYKSMYFYLHIISLLIILFLPMKPQAHTQ 480

Query: 479 RK 480
           R+
Sbjct: 481 RR 482


>gi|225703079 membrane bound O-acyltransferase domain containing 7
           isoform 1 [Homo sapiens]
          Length = 472

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 106/428 (24%), Positives = 168/428 (39%), Gaps = 63/428 (14%)

Query: 78  GLSIAYFNFGNQLYHSLLCIVLQFLILRLMGRTITAVLTTFCFQMAYLLAGYYYTATGNY 137
           GL +  F  G    HSL+ I+  + +++    +  A+   + F  +YLL   ++ A    
Sbjct: 38  GLGLTLFTCGPHTLHSLVTILGTWALIQAQPCSCHALALAWTF--SYLL---FFRALSLL 92

Query: 138 DIKWTMP-----HCVLTLKLIGLAVDYFDGGKDQNS-LSSEQQKYAIRG----VPSLLEV 187
            +    P       +LTLKL+ LA +  D    Q   ++S   K    G    VPSL+E 
Sbjct: 93  GLPTPTPFTNAVQLLLTLKLVSLASEVQDLHLAQRKEMASGFSKGPTLGLLPDVPSLMET 152

Query: 188 AGFSYFYGAFLVGPQFSMNHYMKLVQGELIDIPGKIPNSIIPALKRL-SLGLFYLVGYTL 246
             +SY Y   + GP F    Y+  ++      PG +P S+ P L+R     LF L+   L
Sbjct: 153 LSYSYCYVGIMTGPFFRYRTYLDWLEQ---PFPGAVP-SLRPLLRRAWPAPLFGLL--FL 206

Query: 247 LSPHITEDYLLTED-YDNHPFWFRCMYML-IWGKFVLYKYVTCWLVTEGVCILTGLGFNG 304
           LS H+     + ED +   P   R  YM+ ++  F +  YV  W+  E  CI  G G   
Sbjct: 207 LSSHLFPLEAVREDAFYARPLPARLFYMIPVFFAFRMRFYV-AWIAAECGCIAAGFGAYP 265

Query: 305 FEEKGKA----------------------KWDACANMKVWLFETNPRFTGTIASFNINTN 342
              K +A                       ++   N+  +  +   R    +  +N+   
Sbjct: 266 VAAKARAGGGPTLQCPPPSSPEKAASLEYDYETIRNIDCYSTDFCVRVRDGMRYWNMTVQ 325

Query: 343 AWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLVCFQMEFLIVIVERQAARLIQ 402
            W+A+YI+K      +  L    ++L  A WHGLH GY + F    L +  E +    ++
Sbjct: 326 WWLAQYIYKSAP-ARSYVLRSAWTMLLSAYWHGLHPGYYLSFLTIPLCLAAEGRLESALR 384

Query: 403 ESPTLSKLAAITVLQPFYYLVQQTIHWLF----MGYSMTAFCLFTWDKWLKVYKSIYFLG 458
                        L P        +HW        Y    F L +    L+ + SIYF  
Sbjct: 385 GR-----------LSPGGQKAWDWVHWFLKMRAYDYMCMGFVLLSLADTLRYWASIYFCI 433

Query: 459 HIFFLSLL 466
           H   L+ L
Sbjct: 434 HFLALAAL 441


>gi|225703081 membrane bound O-acyltransferase domain containing 7
           isoform 2 [Homo sapiens]
          Length = 399

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 79/315 (25%), Positives = 122/315 (38%), Gaps = 48/315 (15%)

Query: 181 VPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVQGELIDIPGKIPNSIIPALKRL-SLGLF 239
           VPSL+E   +SY Y   + GP F    Y+  ++      PG +P S+ P L+R     LF
Sbjct: 73  VPSLMETLSYSYCYVGIMTGPFFRYRTYLDWLEQ---PFPGAVP-SLRPLLRRAWPAPLF 128

Query: 240 YLVGYTLLSPHITEDYLLTED-YDNHPFWFRCMYML-IWGKFVLYKYVTCWLVTEGVCIL 297
            L+   LLS H+     + ED +   P   R  YM+ ++  F +  YV  W+  E  CI 
Sbjct: 129 GLL--FLLSSHLFPLEAVREDAFYARPLPARLFYMIPVFFAFRMRFYV-AWIAAECGCIA 185

Query: 298 TGLGFNGFEEKGKA----------------------KWDACANMKVWLFETNPRFTGTIA 335
            G G      K +A                       ++   N+  +  +   R    + 
Sbjct: 186 AGFGAYPVAAKARAGGGPTLQCPPPSSPEKAASLEYDYETIRNIDCYSTDFCVRVRDGMR 245

Query: 336 SFNINTNAWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLVCFQMEFLIVIVER 395
            +N+    W+A+YI+K      +  L    ++L  A WHGLH GY + F    L +  E 
Sbjct: 246 YWNMTVQWWLAQYIYKSAP-ARSYVLRSAWTMLLSAYWHGLHPGYYLSFLTIPLCLAAEG 304

Query: 396 QAARLIQESPTLSKLAAITVLQPFYYLVQQTIHWLF----MGYSMTAFCLFTWDKWLKVY 451
           +    ++             L P        +HW        Y    F L +    L+ +
Sbjct: 305 RLESALRGR-----------LSPGGQKAWDWVHWFLKMRAYDYMCMGFVLLSLADTLRYW 353

Query: 452 KSIYFLGHIFFLSLL 466
            SIYF  H   L+ L
Sbjct: 354 ASIYFCIHFLALAAL 368


>gi|225703033 membrane bound O-acyltransferase domain containing 7
           isoform 2 [Homo sapiens]
          Length = 399

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 79/315 (25%), Positives = 122/315 (38%), Gaps = 48/315 (15%)

Query: 181 VPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVQGELIDIPGKIPNSIIPALKRL-SLGLF 239
           VPSL+E   +SY Y   + GP F    Y+  ++      PG +P S+ P L+R     LF
Sbjct: 73  VPSLMETLSYSYCYVGIMTGPFFRYRTYLDWLEQ---PFPGAVP-SLRPLLRRAWPAPLF 128

Query: 240 YLVGYTLLSPHITEDYLLTED-YDNHPFWFRCMYML-IWGKFVLYKYVTCWLVTEGVCIL 297
            L+   LLS H+     + ED +   P   R  YM+ ++  F +  YV  W+  E  CI 
Sbjct: 129 GLL--FLLSSHLFPLEAVREDAFYARPLPARLFYMIPVFFAFRMRFYV-AWIAAECGCIA 185

Query: 298 TGLGFNGFEEKGKA----------------------KWDACANMKVWLFETNPRFTGTIA 335
            G G      K +A                       ++   N+  +  +   R    + 
Sbjct: 186 AGFGAYPVAAKARAGGGPTLQCPPPSSPEKAASLEYDYETIRNIDCYSTDFCVRVRDGMR 245

Query: 336 SFNINTNAWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLVCFQMEFLIVIVER 395
            +N+    W+A+YI+K      +  L    ++L  A WHGLH GY + F    L +  E 
Sbjct: 246 YWNMTVQWWLAQYIYKSAP-ARSYVLRSAWTMLLSAYWHGLHPGYYLSFLTIPLCLAAEG 304

Query: 396 QAARLIQESPTLSKLAAITVLQPFYYLVQQTIHWLF----MGYSMTAFCLFTWDKWLKVY 451
           +    ++             L P        +HW        Y    F L +    L+ +
Sbjct: 305 RLESALRGR-----------LSPGGQKAWDWVHWFLKMRAYDYMCMGFVLLSLADTLRYW 353

Query: 452 KSIYFLGHIFFLSLL 466
            SIYF  H   L+ L
Sbjct: 354 ASIYFCIHFLALAAL 368


>gi|45439337 porcupine isoform E [Homo sapiens]
          Length = 379

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 65/265 (24%), Positives = 103/265 (38%), Gaps = 29/265 (10%)

Query: 93  SLLCIVLQFLILRLMGRTITAVLTTFCFQMAYLLAGYYYTATGNYDIKWTMPHCVLTLKL 152
           SLLC ++ FL      R +   +T     + YLL G  +        K      ++ +K 
Sbjct: 8   SLLCYLVLFLCRHSSHRGVFLSVTI----LIYLLMGEMHMVDTVTWHKMRGAQMIVAMKA 63

Query: 153 IGLAVDYFDGGKDQNSLSSEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLV 212
           + L  D  D G+             +  VPS +E  G+ YF G  + GP  S + Y++ V
Sbjct: 64  VSLGFD-LDRGE-------------VGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV 109

Query: 213 QGELIDIPGKIPNSIIPALKRLSLGLFYLVGYTLLSPHITEDYLLTEDYDNHPFWFRCMY 272
           QG  +         +    + L+L L  LV  T + P++   ++          W R   
Sbjct: 110 QGRPLSC-----RWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRKWLRAYE 164

Query: 273 MLIWGKFVLYKYVTCWLVTEGVCILTGLGFNGFEEKGKAKWDACANMKVWLFETNPRFTG 332
             +   F    Y   +L +E    L G GF   EEK   +WD   + K    E       
Sbjct: 165 SAV--SFHFSNYFVGFL-SEATATLAGAGFT--EEKDHLEWDLTVS-KPLNVELPRSMVE 218

Query: 333 TIASFNINTNAWVARYIFKRLKFLG 357
            + S+N+  + W+  Y+FK    LG
Sbjct: 219 VVTSWNLPMSYWLNNYVFKNALRLG 243


>gi|45439331 porcupine isoform B [Homo sapiens]
          Length = 456

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 66/271 (24%), Positives = 105/271 (38%), Gaps = 35/271 (12%)

Query: 93  SLLCIVLQFLILRLMGRTITAVLTTFCFQMAYLLAGYYYTATGNYDIKWTMPHCVLTLKL 152
           SLLC ++ FL      R +   +T     + YLL G  +        K      ++ +K 
Sbjct: 79  SLLCYLVLFLCRHSSHRGVFLSVTI----LIYLLMGEMHMVDTVTWHKMRGAQMIVAMKA 134

Query: 153 IGLAVDYFDGGKDQNSLSSEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLV 212
           + L  D  D G+             +  VPS +E  G+ YF G  + GP  S + Y++ V
Sbjct: 135 VSLGFD-LDRGE-------------VGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV 180

Query: 213 QGELIDIPGKIPNSIIPALKRLSLGLFYLVGYTLLSPHITEDYL------LTEDYDNHPF 266
           QG  +         +    + L+L L  LV  T + P++   ++      L  +      
Sbjct: 181 QGRPLSC-----RWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRNKKRKAR 235

Query: 267 WFRCMYMLIWGKFVLYKYVTCWLVTEGVCILTGLGFNGFEEKGKAKWDACANMKVWLFET 326
           W R     +   F    Y   +L +E    L G GF   EEK   +WD   + K    E 
Sbjct: 236 WLRAYESAV--SFHFSNYFVGFL-SEATATLAGAGFT--EEKDHLEWDLTVS-KPLNVEL 289

Query: 327 NPRFTGTIASFNINTNAWVARYIFKRLKFLG 357
                  + S+N+  + W+  Y+FK    LG
Sbjct: 290 PRSMVEVVTSWNLPMSYWLNNYVFKNALRLG 320


>gi|45439329 porcupine isoform A [Homo sapiens]
          Length = 450

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 65/265 (24%), Positives = 103/265 (38%), Gaps = 29/265 (10%)

Query: 93  SLLCIVLQFLILRLMGRTITAVLTTFCFQMAYLLAGYYYTATGNYDIKWTMPHCVLTLKL 152
           SLLC ++ FL      R +   +T     + YLL G  +        K      ++ +K 
Sbjct: 79  SLLCYLVLFLCRHSSHRGVFLSVTI----LIYLLMGEMHMVDTVTWHKMRGAQMIVAMKA 134

Query: 153 IGLAVDYFDGGKDQNSLSSEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLV 212
           + L  D  D G+             +  VPS +E  G+ YF G  + GP  S + Y++ V
Sbjct: 135 VSLGFD-LDRGE-------------VGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV 180

Query: 213 QGELIDIPGKIPNSIIPALKRLSLGLFYLVGYTLLSPHITEDYLLTEDYDNHPFWFRCMY 272
           QG  +         +    + L+L L  LV  T + P++   ++          W R   
Sbjct: 181 QGRPLSC-----RWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRKWLRAYE 235

Query: 273 MLIWGKFVLYKYVTCWLVTEGVCILTGLGFNGFEEKGKAKWDACANMKVWLFETNPRFTG 332
             +   F    Y   +L +E    L G GF   EEK   +WD   + K    E       
Sbjct: 236 SAV--SFHFSNYFVGFL-SEATATLAGAGFT--EEKDHLEWDLTVS-KPLNVELPRSMVE 289

Query: 333 TIASFNINTNAWVARYIFKRLKFLG 357
            + S+N+  + W+  Y+FK    LG
Sbjct: 290 VVTSWNLPMSYWLNNYVFKNALRLG 314


>gi|225703037 membrane bound O-acyltransferase domain containing 7
           isoform 3 [Homo sapiens]
          Length = 344

 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 78/309 (25%), Positives = 127/309 (41%), Gaps = 47/309 (15%)

Query: 78  GLSIAYFNFGNQLYHSLLCIVLQFLILRLMGRTITAVLTTFCFQMAYLLAGYYYTATGNY 137
           GL +  F  G    HSL+ I+  + +++    +  A+   + F  +YLL   ++ A    
Sbjct: 38  GLGLTLFTCGPHTLHSLVTILGTWALIQAQPCSCHALALAWTF--SYLL---FFRALSLL 92

Query: 138 DIKWTMP-----HCVLTLKLIGLAVDYFDGGKDQNS-LSSEQQKYAIRG----VPSLLEV 187
            +    P       +LTLKL+ LA +  D    Q   ++S   K    G    VPSL+E 
Sbjct: 93  GLPTPTPFTNAVQLLLTLKLVSLASEVQDLHLAQRKEMASGFSKGPTLGLLPDVPSLMET 152

Query: 188 AGFSYFYGAFLVGPQFSMNHYMKLVQGELIDIPGKIPNSIIPALKRL-SLGLFYLVGYTL 246
             +SY Y   + GP F    Y+  ++      PG +P S+ P L+R     LF L+   L
Sbjct: 153 LSYSYCYVGIMTGPFFRYRTYLDWLEQ---PFPGAVP-SLRPLLRRAWPAPLFGLL--FL 206

Query: 247 LSPHITEDYLLTED-YDNHPFWFRCMYML-IWGKFVLYKYVTCWLVTEGVCILTGLGFNG 304
           LS H+     + ED +   P   R  YM+ ++  F +  YV  W+  E  CI  G G   
Sbjct: 207 LSSHLFPLEAVREDAFYARPLPARLFYMIPVFFAFRMRFYV-AWIAAECGCIAAGFGAYP 265

Query: 305 FEEKGKA----------------------KWDACANMKVWLFETNPRFTGTIASFNINTN 342
              K +A                       ++   N+  +  +   R    +  +N+   
Sbjct: 266 VAAKARAGGGPTLQCPPPSSPEKAASLEYDYETIRNIDCYSTDFCVRVRDGMRYWNMTVQ 325

Query: 343 AWVARYIFK 351
            W+A+YI+K
Sbjct: 326 WWLAQYIYK 334


>gi|45439333 porcupine isoform C [Homo sapiens]
          Length = 455

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 68/272 (25%), Positives = 105/272 (38%), Gaps = 38/272 (13%)

Query: 93  SLLCIVLQFLILRLMGRTITAVLTTFCFQMAYLLAGYYYTATGNYDIKWTMPHCVLTLKL 152
           SLLC ++ FL      R +   +T     + YLL G  +        K      ++ +K 
Sbjct: 79  SLLCYLVLFLCRHSSHRGVFLSVTI----LIYLLMGEMHMVDTVTWHKMRGAQMIVAMKA 134

Query: 153 IGLAVDYFDGGKDQNSLSSEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLV 212
           + L  D  D G+             +  VPS +E  G+ YF G  + GP  S + Y++ V
Sbjct: 135 VSLGFD-LDRGE-------------VGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV 180

Query: 213 QGELIDIPGKIPNSIIPALKRLSLGLFYLVGYTLLSPH-------ITEDYLLTEDYDNHP 265
           QG  +         +    + L+L L  LV  T + P+       +  D LL +      
Sbjct: 181 QGRPLSC-----RWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRK--GTMV 233

Query: 266 FWFRCMYMLIWGKFVLYKYVTCWLVTEGVCILTGLGFNGFEEKGKAKWDACANMKVWLFE 325
            W R     +   F    Y   +L +E    L G GF   EEK   +WD   + K    E
Sbjct: 234 RWLRAYESAV--SFHFSNYFVGFL-SEATATLAGAGFT--EEKDHLEWDLTVS-KPLNVE 287

Query: 326 TNPRFTGTIASFNINTNAWVARYIFKRLKFLG 357
                   + S+N+  + W+  Y+FK    LG
Sbjct: 288 LPRSMVEVVTSWNLPMSYWLNNYVFKNALRLG 319


>gi|45439335 porcupine isoform D [Homo sapiens]
          Length = 461

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 62/273 (22%), Positives = 107/273 (39%), Gaps = 34/273 (12%)

Query: 93  SLLCIVLQFLILRLMGRTITAVLTTFCFQMAYLLAGYYYTATGNYDIKWTMPHCVLTLKL 152
           SLLC ++ FL      R +   +T     + YLL G  +        K      ++ +K 
Sbjct: 79  SLLCYLVLFLCRHSSHRGVFLSVTI----LIYLLMGEMHMVDTVTWHKMRGAQMIVAMKA 134

Query: 153 IGLAVDYFDGGKDQNSLSSEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLV 212
           + L  D  D G+             +  VPS +E  G+ YF G  + GP  S + Y++ V
Sbjct: 135 VSLGFD-LDRGE-------------VGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV 180

Query: 213 QGELIDIPGKIPNSIIPALKRLSLGLFYLVGYTLLSPHITEDYL------LTEDYDNHPF 266
           QG  +         +    + L+L L  LV  T + P++   ++      L  +      
Sbjct: 181 QGRPLSC-----RWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRNKKRKAR 235

Query: 267 WFRCMYMLIWGKFVLYKYVTCWL--VTEGVCILTGLGFNGFEEKGKAKWDACANMKVWLF 324
                ++  +   V + +   ++  ++E    L G GF   EEK   +WD   + K    
Sbjct: 236 GTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFT--EEKDHLEWDLTVS-KPLNV 292

Query: 325 ETNPRFTGTIASFNINTNAWVARYIFKRLKFLG 357
           E        + S+N+  + W+  Y+FK    LG
Sbjct: 293 ELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLG 325


>gi|189571629 membrane bound O-acyltransferase domain containing 4
           [Homo sapiens]
          Length = 435

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 79/359 (22%), Positives = 141/359 (39%), Gaps = 42/359 (11%)

Query: 46  ISIFLG--YPFALFYRHYLFYKETYLI---HLFHTFTGLSIAYFNFGNQ---LYHSLLCI 97
           IS + G  +PFAL + +YL   +++     +LF    G ++A    G+    ++   +C 
Sbjct: 12  ISFYQGAAFPFALLF-NYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYAVLVFTPAVCA 70

Query: 98  VLQFLILRLMGRTITAVLTTFCFQMAYLLA---GYYYTATGNYDIKWTMPHCV------- 147
           V   L+  L  + +     TFCFQM++      G +YT    ++   ++  C+       
Sbjct: 71  VA--LLCSLAPQQVHR--WTFCFQMSWQTLCHLGLHYTEYYLHEPP-SVRFCITLSSLML 125

Query: 148 LTLKLIGLAVDYFDGGKDQNSLSSEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNH 207
           LT ++  L++D  +G     S     +      V   L    +  F+ A L G   S   
Sbjct: 126 LTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSLCSFQR 185

Query: 208 YMKLVQGELIDIPGKIPNSIIPALKRLSLGLFYLVGYTLLSPHITEDYLLTEDYDNHPFW 267
           +   VQG         P     AL    L +  L    +    + +      D       
Sbjct: 186 FQARVQGS----SALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQ---- 237

Query: 268 FRCMYMLIWGKFVLYK--YVTCWLVTEGVCILTGLGFNGFEEKGKAKWDACANMKVWLFE 325
           F C+Y+ +W    L+K  Y + W++ + +    G G    +  G+  +   A+  +W  E
Sbjct: 238 FECIYV-VWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDAD--IWTLE 294

Query: 326 TNPRFTGTIASFNINTNAWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLVCF 384
              R +     +N +T  W+ R +F+  +     +     +  F A WHGLH G +  F
Sbjct: 295 RTHRISVFSRKWNQSTARWLRRLVFQHSRAWPLLQ-----TFAFSAWWHGLHPGQVFGF 348


>gi|31083053 ceroid-lipofuscinosis, neuronal 8 [Homo sapiens]
          Length = 286

 Score = 30.4 bits (67), Expect = 3.8
 Identities = 21/60 (35%), Positives = 30/60 (50%), Gaps = 6/60 (10%)

Query: 161 DGGKDQNSLSSEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMN---HYMKLVQGELI 217
           DGG  ++    +   YA  G+ S L VAGF ++ G F+V  Q S +    Y  LV  E +
Sbjct: 6   DGGTSESIFDLD---YASWGIRSTLMVAGFVFYLGVFVVCHQLSSSLNATYRSLVAREKV 62


>gi|170784861 hedgehog acyltransferase [Homo sapiens]
          Length = 493

 Score = 30.4 bits (67), Expect = 3.8
 Identities = 22/79 (27%), Positives = 40/79 (50%), Gaps = 8/79 (10%)

Query: 330 FTGTIASFNINTNAWVARYIF-----KRLKFLGNKELSQGLSLLFLALWHGLHSGYLVCF 384
           FTG    F++  + ++ RY++      +   LG    S  ++  F++ WHG +  YL C+
Sbjct: 331 FTGMWRYFDVGLHNFLIRYVYIPVGGSQHGLLGTL-FSTAMTFAFVSYWHGGYD-YLWCW 388

Query: 385 -QMEFLIVIVERQAARLIQ 402
             + +L V VE    RL++
Sbjct: 389 AALNWLGVTVENGVRRLVE 407


>gi|170784863 hedgehog acyltransferase [Homo sapiens]
          Length = 493

 Score = 30.4 bits (67), Expect = 3.8
 Identities = 22/79 (27%), Positives = 40/79 (50%), Gaps = 8/79 (10%)

Query: 330 FTGTIASFNINTNAWVARYIF-----KRLKFLGNKELSQGLSLLFLALWHGLHSGYLVCF 384
           FTG    F++  + ++ RY++      +   LG    S  ++  F++ WHG +  YL C+
Sbjct: 331 FTGMWRYFDVGLHNFLIRYVYIPVGGSQHGLLGTL-FSTAMTFAFVSYWHGGYD-YLWCW 388

Query: 385 -QMEFLIVIVERQAARLIQ 402
             + +L V VE    RL++
Sbjct: 389 AALNWLGVTVENGVRRLVE 407


>gi|169217968 PREDICTED: similar to solute carrier family 16, member
           5 [Homo sapiens]
          Length = 453

 Score = 29.6 bits (65), Expect = 6.5
 Identities = 41/162 (25%), Positives = 59/162 (36%), Gaps = 22/162 (13%)

Query: 31  LATSLGASEQALRLIISIFLGYPFALFYRHYLFYKETYLIHL----------FHTFTGLS 80
           L + +G S   LR +  +  G P    +R YLF     L  L          F    G  
Sbjct: 224 LISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYC 283

Query: 81  IAY----FNFGNQLYHSLLCIVLQFLILRLMGRTITAVLTTFCFQMAYLLAGYYYTATGN 136
           +AY       G  ++  L+ IV      R +G  +  VL    F ++  LAG    AT N
Sbjct: 284 LAYSVSMSGIGALIFQVLMDIVPMDQFPRALG--LFTVLDGLAFLISPPLAGLLLDATNN 341

Query: 137 YDIKWTMPHCVLTLKLIGLAVDYFDGGKDQNSLSSEQQKYAI 178
           +   + M    L      ++   F GG        EQ K A+
Sbjct: 342 FSYVFYMSSFFL------ISAALFMGGSFYALQKKEQGKQAV 377


>gi|4885505 N-acetylated alpha-linked acidic dipeptidase 2 [Homo
           sapiens]
          Length = 740

 Score = 29.6 bits (65), Expect = 6.5
 Identities = 14/40 (35%), Positives = 22/40 (55%)

Query: 50  LGYPFALFYRHYLFYKETYLIHLFHTFTGLSIAYFNFGNQ 89
           LG P  LFYRH +F   ++  +   +F G+  A F+  N+
Sbjct: 669 LGLPGKLFYRHIIFAPSSHNKYAGESFPGIYDAIFDIENK 708


>gi|4759116 solute carrier family 16, member 5 [Homo sapiens]
          Length = 505

 Score = 29.6 bits (65), Expect = 6.5
 Identities = 41/162 (25%), Positives = 59/162 (36%), Gaps = 22/162 (13%)

Query: 31  LATSLGASEQALRLIISIFLGYPFALFYRHYLFYKETYLIHL----------FHTFTGLS 80
           L + +G S   LR +  +  G P    +R YLF     L  L          F    G  
Sbjct: 276 LISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYC 335

Query: 81  IAY----FNFGNQLYHSLLCIVLQFLILRLMGRTITAVLTTFCFQMAYLLAGYYYTATGN 136
           +AY       G  ++  L+ IV      R +G  +  VL    F ++  LAG    AT N
Sbjct: 336 LAYSVSMSGIGALIFQVLMDIVPMDQFPRALG--LFTVLDGLAFLISPPLAGLLLDATNN 393

Query: 137 YDIKWTMPHCVLTLKLIGLAVDYFDGGKDQNSLSSEQQKYAI 178
           +   + M    L      ++   F GG        EQ K A+
Sbjct: 394 FSYVFYMSSFFL------ISAALFMGGSFYALQKKEQGKQAV 429


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.329    0.143    0.454 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,903,297
Number of Sequences: 37866
Number of extensions: 706987
Number of successful extensions: 1680
Number of sequences better than 10.0: 19
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 1641
Number of HSP's gapped (non-prelim): 23
length of query: 487
length of database: 18,247,518
effective HSP length: 106
effective length of query: 381
effective length of database: 14,233,722
effective search space: 5423048082
effective search space used: 5423048082
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.