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Search of human proteins with 41872522
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens]
(945 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens] 1956 0.0
gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens] 1820 0.0
gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens] 1810 0.0
gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens] 1803 0.0
gi|4758156 diacylglycerol kinase, iota [Homo sapiens] 1182 0.0
gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens] 293 5e-79
gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens] 291 2e-78
gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens] 285 1e-76
gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 279 1e-74
gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 279 1e-74
gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 279 1e-74
gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 279 1e-74
gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens] 270 6e-72
gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens] 253 6e-67
gi|40806175 diacylglycerol kinase, theta [Homo sapiens] 238 3e-62
gi|4503313 diacylglycerol kinase epsilon [Homo sapiens] 217 4e-56
gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens] 152 2e-36
gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens] 152 2e-36
gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo ... 150 5e-36
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ... 150 5e-36
gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 134 5e-31
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 57 6e-08
gi|20270347 ankyrin repeat domain 54 [Homo sapiens] 54 9e-07
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 53 1e-06
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 53 1e-06
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun... 51 6e-06
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit... 51 6e-06
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 50 8e-06
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 50 8e-06
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 50 8e-06
>gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens]
Length = 945
Score = 1956 bits (5068), Expect = 0.0
Identities = 945/945 (100%), Positives = 945/945 (100%)
Query: 1 MAEGQGGGGQRWDWAGGGRAAEEEVVRRRCRRGEEAQVAQPWPEGSRGTAAGPPVEERFR 60
MAEGQGGGGQRWDWAGGGRAAEEEVVRRRCRRGEEAQVAQPWPEGSRGTAAGPPVEERFR
Sbjct: 1 MAEGQGGGGQRWDWAGGGRAAEEEVVRRRCRRGEEAQVAQPWPEGSRGTAAGPPVEERFR 60
Query: 61 QLHLRKQVSYRKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFET 120
QLHLRKQVSYRKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFET
Sbjct: 61 QLHLRKQVSYRKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFET 120
Query: 121 NVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRN 180
NVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRN
Sbjct: 121 NVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRN 180
Query: 181 VREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFML 240
VREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFML
Sbjct: 181 VREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFML 240
Query: 241 QQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPF 300
QQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPF
Sbjct: 241 QQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPF 300
Query: 301 IIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKV 360
IIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKV
Sbjct: 301 IIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKV 360
Query: 361 HNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSK 420
HNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSK
Sbjct: 361 HNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSK 420
Query: 421 ILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEF 480
ILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEF
Sbjct: 421 ILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEF 480
Query: 481 HESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQ 540
HESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQ
Sbjct: 481 HESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQ 540
Query: 541 CVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQ 600
CVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQ
Sbjct: 541 CVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQ 600
Query: 601 CREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQ 660
CREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQ
Sbjct: 601 CREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQ 660
Query: 661 LRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGA 720
LRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGA
Sbjct: 661 LRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGA 720
Query: 721 KSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDL 780
KSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDL
Sbjct: 721 KSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDL 780
Query: 781 PTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQS 840
PTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQS
Sbjct: 781 PTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQS 840
Query: 841 RTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGAS 900
RTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGAS
Sbjct: 841 RTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGAS 900
Query: 901 LMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 945
LMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
Sbjct: 901 LMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 945
>gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens]
Length = 1117
Score = 1820 bits (4713), Expect = 0.0
Identities = 890/933 (95%), Positives = 895/933 (95%), Gaps = 14/933 (1%)
Query: 27 RRRCRRGEEAQVAQPWPEGSRGTAAGPPVEERFRQLHLRKQVSYR--------------K 72
RR +R Q P + GT AG + R R L R+QV+ R K
Sbjct: 185 RRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSALLAK 244
Query: 73 AITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQ 132
AITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQ
Sbjct: 245 AITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQ 304
Query: 133 YCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWV 192
YCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWV
Sbjct: 305 YCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWV 364
Query: 193 HRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVH 252
HRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVH
Sbjct: 365 HRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVH 424
Query: 253 AAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKP 312
AAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKP
Sbjct: 425 AAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKP 484
Query: 313 LLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDG 372
LLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDG
Sbjct: 485 LLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDG 544
Query: 373 TVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQ 432
TVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQ
Sbjct: 545 TVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQ 604
Query: 433 LDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFN 492
LDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFN
Sbjct: 605 LDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFN 664
Query: 493 SRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCA 552
SRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCA
Sbjct: 665 SRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCA 724
Query: 553 GTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAI 612
GTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAI
Sbjct: 725 GTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAI 784
Query: 613 PVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHD 672
PVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHD
Sbjct: 785 PVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHD 844
Query: 673 YEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKW 732
YEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKW
Sbjct: 845 YEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKW 904
Query: 733 CFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPC 792
CFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPC
Sbjct: 905 CFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPC 964
Query: 793 SPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGS 852
SPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGS
Sbjct: 965 SPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGS 1024
Query: 853 KDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPR 912
KDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPR
Sbjct: 1025 KDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPR 1084
Query: 913 QRAEKAQDTELAAYLENRQHYQMIQREDQETAV 945
QRAEKAQDTELAAYLENRQHYQMIQREDQETAV
Sbjct: 1085 QRAEKAQDTELAAYLENRQHYQMIQREDQETAV 1117
>gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens]
Length = 929
Score = 1810 bits (4687), Expect = 0.0
Identities = 885/920 (96%), Positives = 894/920 (97%), Gaps = 7/920 (0%)
Query: 32 RGEEAQVAQPWPEGSRGTAAGPPVEERFRQLHLRK-----QVSYRKAITKSGLQHLAPPP 86
R +++ A GS A GP ++ R+L+ R+ +RKAITKSGLQHLAPPP
Sbjct: 11 RSSDSESASASSSGSERDA-GPEPDKAPRRLNKRRFPGLRLFGHRKAITKSGLQHLAPPP 69
Query: 87 PTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARML-KSVSRR 145
PTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARML KSVSRR
Sbjct: 70 PTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLQKSVSRR 129
Query: 146 KCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCG 205
KCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCG
Sbjct: 130 KCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCG 189
Query: 206 KGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRA 265
KGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRA
Sbjct: 190 KGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRA 249
Query: 266 RRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQ 325
RRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQ
Sbjct: 250 RRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQ 309
Query: 326 GAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLR 385
GAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLR
Sbjct: 310 GAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLR 369
Query: 386 LKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPE 445
LKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPE
Sbjct: 370 LKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPE 429
Query: 446 AGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTA 505
AGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTA
Sbjct: 430 AGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTA 489
Query: 506 FSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD 565
FSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD
Sbjct: 490 FSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD 549
Query: 566 FEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAA 625
FEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAA
Sbjct: 550 FEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAA 609
Query: 626 SRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKE 685
SRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKE
Sbjct: 610 SRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKE 669
Query: 686 ASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYR 745
ASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYR
Sbjct: 670 ASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYR 729
Query: 746 IDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAP 805
IDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAP
Sbjct: 730 IDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAP 789
Query: 806 PQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPP 865
PQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPP
Sbjct: 790 PQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPP 849
Query: 866 EILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAA 925
EILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAA
Sbjct: 850 EILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAA 909
Query: 926 YLENRQHYQMIQREDQETAV 945
YLENRQHYQMIQREDQETAV
Sbjct: 910 YLENRQHYQMIQREDQETAV 929
>gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens]
Length = 895
Score = 1803 bits (4670), Expect = 0.0
Identities = 874/876 (99%), Positives = 875/876 (99%), Gaps = 1/876 (0%)
Query: 71 RKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVG 130
+KAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVG
Sbjct: 20 QKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVG 79
Query: 131 EQYCVARML-KSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRH 189
EQYCVARML KSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRH
Sbjct: 80 EQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRH 139
Query: 190 HWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSL 249
HWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSL
Sbjct: 140 HWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSL 199
Query: 250 GVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPL 309
GVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPL
Sbjct: 200 GVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPL 259
Query: 310 MKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACG 369
MKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACG
Sbjct: 260 MKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACG 319
Query: 370 GDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGN 429
GDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGN
Sbjct: 320 GDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGN 379
Query: 430 VVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPE 489
VVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPE
Sbjct: 380 VVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPE 439
Query: 490 KFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPR 549
KFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPR
Sbjct: 440 KFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPR 499
Query: 550 YCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTS 609
YCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTS
Sbjct: 500 YCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTS 559
Query: 610 KAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVS 669
KAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVS
Sbjct: 560 KAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVS 619
Query: 670 MHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLS 729
MHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLS
Sbjct: 620 MHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLS 679
Query: 730 PKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPT 789
PKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPT
Sbjct: 680 PKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPT 739
Query: 790 SPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVS 849
SPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVS
Sbjct: 740 SPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVS 799
Query: 850 TGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGD 909
TGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGD
Sbjct: 800 TGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGD 859
Query: 910 TPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 945
TPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
Sbjct: 860 TPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 895
>gi|4758156 diacylglycerol kinase, iota [Homo sapiens]
Length = 1065
Score = 1182 bits (3059), Expect = 0.0
Identities = 590/960 (61%), Positives = 721/960 (75%), Gaps = 81/960 (8%)
Query: 55 VEERFRQLHLRKQVSYRKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGE 114
+EE+ R L RKQVSYRKAI+++GLQHLAP P + ++ R+T+DWSE+A GE
Sbjct: 118 LEEKLRNLTFRKQVSYRKAISRAGLQHLAPAHPLSLPVANGPAKEPRATLDWSENAVNGE 177
Query: 115 HIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFR 174
H+W ETNVSGD CY+GE+ C R KS RRKCA CKIVVHT CIEQLEKINFRCKP+FR
Sbjct: 178 HLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFR 237
Query: 175 ESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSK 234
E GSR+ RE FVRHHWVHRRRQ+GKC+ CGKGFQQKF+FHSKEIVAISCSWCKQA+H+K
Sbjct: 238 EGGSRSPRE-NFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNK 296
Query: 235 VSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKAS-KKKKRASFKRKSSKKGPE 293
V+CFML IEEPCSLG HAAV++PPTWI++ ++PQN+LKAS +KKKR SFKRK+SK+G E
Sbjct: 297 VTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGME 356
Query: 294 -EGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKE 352
E + RPF+I+P SPLMKPLLVFVNPKSGGNQG K++Q F+WYLNPRQVFDLSQ GPK+
Sbjct: 357 QENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKD 416
Query: 353 ALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGG 412
ALE+YRKV NLRILACGGDGTVGWILS LD+L+L P PPV +LPLGTGNDLARTLNWGGG
Sbjct: 417 ALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGG 476
Query: 413 YTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGF 472
YTDEPVSKIL VE+G VVQLDRW+LH E NP+ PE+ ++G +LPL+VFNNYFSLGF
Sbjct: 477 YTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVC-KLPLNVFNNYFSLGF 535
Query: 473 DAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTP 532
DAHVTLEFHESREANPEKFNSRFRNKMFYAG AFSDFL SS+DL+KH++VVCDG DLTP
Sbjct: 536 DAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTP 595
Query: 533 KIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVG 592
KIQ+LK QC+VFLNIPRYCAGTMPWG+PG+HHDFEPQRHDDGY+EVIGFTM SLAALQVG
Sbjct: 596 KIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVG 655
Query: 593 GHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHS 652
GHGERL QCREV+L T K+IP+QVDGEPC+LA + IRI+LRNQA MVQK+KRR++ PL +
Sbjct: 656 GHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLN 715
Query: 653 DQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEAS------------------VPLGTVV 694
D Q VP++LRI+V+++S+ DYE HYDKE+L+EAS +PLG +V
Sbjct: 716 DPQSVPDRLRIRVNKISLQDYEGFHYDKEKLREASISDWLRTIAGELVQSFGAIPLGILV 775
Query: 695 VPGDSDLELCRAHIERLQQEPDGAGAKSP---------------TCQKLSPKWCFLDATT 739
V GD DLE CR +I+RLQ++ + S + Q+LSP+WCFLD
Sbjct: 776 VRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDHETSFPRALSAQRLSPRWCFLD--- 832
Query: 740 ASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGAS------ARPDLPTPTSPLPTSPCS 793
DR+QEHL++V EI+QDEI+ILDP+++ + PDL + + +
Sbjct: 833 -------DRSQEHLHFVMEISQDEIFILDPDMVVSQPAGTPPGMPDLVVEQASGISDWWN 885
Query: 794 PTPR------SLQGDAAP---------------------PQGEELIEAAKRNDFCKLQEL 826
P R S G AP + +++A D KL E
Sbjct: 886 PALRKRMLSDSGLGMIAPYYEDSDLKDLSHSRVLQSPVSSEDHAILQAVIAGDLMKLIES 945
Query: 827 HRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILD-AVEENGETCLHQAAAL 885
++ GG L+ + +LLH+A TG+ ++V+Y+LDH P E+LD A E GET LH+AA
Sbjct: 946 YKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQ 1005
Query: 886 GQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 945
R +C +V+AGASL KTD +G TP++RA++A D +LAAYLE+RQ+Y++I ED ETAV
Sbjct: 1006 RNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHEDLETAV 1065
>gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens]
Length = 804
Score = 293 bits (750), Expect = 5e-79
Identities = 191/575 (33%), Positives = 276/575 (48%), Gaps = 84/575 (14%)
Query: 113 GEHIWFETNVSGDFCYVGEQYC--VARMLKSVSRRK--CAACKIVVHTPCIEQLEKINFR 168
G+H+W + + YC ML V ++ C+ CK VH C+ R
Sbjct: 243 GQHVWRLKHFNKP------AYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVA-------R 289
Query: 169 CKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCK 228
PS ++ ++ R + H+WV KC C K + + + + C WC+
Sbjct: 290 APPSCIKTYVKSKRNTDVMHHYWVEGNCPT-KCDKCHKTVKCY-----QGLTGLHCVWCQ 343
Query: 229 QAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI---LRARRPQNTLKASKKKKRASFKR 285
H+K + ++ C G ++PPT I + P + + ++++ K
Sbjct: 344 ITLHNKCA----SHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKE 399
Query: 286 KSSKKGPEEGRWRPFIIRP------------TPSPLMKPLLVFVNPKSGGNQGAKIIQSF 333
KS + P + + + R TP P PLLVFVNPKSGG QG +I + F
Sbjct: 400 KSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKF 459
Query: 334 LWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVA 393
+ LNPRQV+ LS GP L +R V + R+LACGGDGTVGW+L +++ + PPVA
Sbjct: 460 QYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVA 519
Query: 394 ILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDE 453
ILPLGTGNDLAR L WGGGY E + KIL +E + LDRW PN D+DE
Sbjct: 520 ILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPN------DKDE 573
Query: 454 GATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGS 513
D +P + NNYFS+G DA + FH RE +PEKFNSR +NK +Y S+ +
Sbjct: 574 KG-DPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSAT 632
Query: 514 SKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD-------- 565
K L + + + CDG+ + + ++ + + LNIP G+ WG +
Sbjct: 633 CKKLHESVEIECDGVQI--DLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKG 690
Query: 566 --------------FEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREV 604
F Q D LEV+G A+++G G RL QC V
Sbjct: 691 SDKRTTVTDAKELKFASQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCSCV 746
Query: 605 VLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMV 639
V+ TSK++P+Q+DGEP I+I +NQA M+
Sbjct: 747 VIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPML 781
>gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens]
Length = 791
Score = 291 bits (746), Expect = 2e-78
Identities = 196/573 (34%), Positives = 277/573 (48%), Gaps = 83/573 (14%)
Query: 104 VDWSESATYGEHIW----FETNVSGDFCYVGEQYCVARMLKSVSRRK--CAACKIVVHTP 157
+D S S G H W F+ +FC++ ML V ++ C CK VH
Sbjct: 261 MDDSGSKGDGRHAWTMKHFKKPTYCNFCHI--------MLMGVRKQGLCCTYCKYTVHER 312
Query: 158 CIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSK 217
C+ R P ++ S+ R ++H WV KC C K + +
Sbjct: 313 CVS-------RNIPGCVKTYSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCY-----Q 359
Query: 218 EIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKK 277
+ A C WC+ +H K ++ C G ++ PT I R + K+
Sbjct: 360 SVTARHCVWCRMTFHRKC------ELSTLCDGGELRDHILLPTSICPITRDRPGEKSD-- 411
Query: 278 KKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYL 337
S KG +++ I PTP PLLV VNPKSGG QG +I++ F + L
Sbjct: 412 -------GCVSAKGELVMQYK---IIPTPG--THPLLVLVNPKSGGRQGERILRKFHYLL 459
Query: 338 NPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPL 397
NP+QVF+L GGP L +R + R+LACGGDGTVGWIL +D+ PPVA+LPL
Sbjct: 460 NPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPL 519
Query: 398 GTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATD 457
GTGNDLAR L WGGGY ++KIL +E+ +V LDRW L P E+ + G D
Sbjct: 520 GTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPR-----EEVENG--D 572
Query: 458 RLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDL 517
++P + NNYFS+G DA + FH RE +PEKFNSR +NK++Y S+ + K L
Sbjct: 573 QVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKL 632
Query: 518 AKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHH------------- 564
HI + CDG+ + + ++ + + LNIP GT WG ++
Sbjct: 633 HDHIELECDGVGV--DLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDP 690
Query: 565 ---DFEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVLTTSKAIPV 614
F Q D LEV+G A+++G G RL QC V + T+K +P+
Sbjct: 691 KELKFCVQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPM 746
Query: 615 QVDGEPCKLAASRIRIALRNQATMVQKAKRRSA 647
QVDGEP I+I +NQA M+ ++S+
Sbjct: 747 QVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSS 779
>gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens]
Length = 773
Score = 285 bits (729), Expect = 1e-76
Identities = 185/556 (33%), Positives = 267/556 (48%), Gaps = 84/556 (15%)
Query: 113 GEHIWFETNVSGDFCYVGEQYC--VARMLKSVSRRK--CAACKIVVHTPCIEQLEKINFR 168
G+H+W + + YC ML V ++ C+ CK VH C+ R
Sbjct: 243 GQHVWRLKHFNKP------AYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVA-------R 289
Query: 169 CKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCK 228
PS ++ ++ R + H+WV KC C K + + + + C WC+
Sbjct: 290 APPSCIKTYVKSKRNTDVMHHYWVEGNCPT-KCDKCHKTVKCY-----QGLTGLHCVWCQ 343
Query: 229 QAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI---LRARRPQNTLKASKKKKRASFKR 285
H+K + ++ C G ++PPT I + P + + ++++ K
Sbjct: 344 ITLHNKCA----SHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKE 399
Query: 286 KSSKKGPEEGRWRPFIIRP------------TPSPLMKPLLVFVNPKSGGNQGAKIIQSF 333
KS + P + + + R TP P PLLVFVNPKSGG QG +I + F
Sbjct: 400 KSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKF 459
Query: 334 LWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVA 393
+ LNPRQV+ LS GP L +R V + R+LACGGDGTVGW+L +++ + PPVA
Sbjct: 460 QYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVA 519
Query: 394 ILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDE 453
ILPLGTGNDLAR L WGGGY E + KIL +E + LDRW PN D+DE
Sbjct: 520 ILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPN------DKDE 573
Query: 454 GATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGS 513
D +P + NNYFS+G DA + FH RE +PEKFNSR +NK +Y S+ +
Sbjct: 574 KG-DPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSAT 632
Query: 514 SKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD-------- 565
K L + + + CDG+ + + ++ + + LNIP G+ WG +
Sbjct: 633 CKKLHESVEIECDGVQI--DLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKG 690
Query: 566 --------------FEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREV 604
F Q D LEV+G A+++G G RL QC V
Sbjct: 691 SDKRTTVTDAKELKFASQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCSCV 746
Query: 605 VLTTSKAIPVQVDGEP 620
V+ TSK++P+Q+DGEP
Sbjct: 747 VIRTSKSLPMQIDGEP 762
>gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 279 bits (713), Expect = 1e-74
Identities = 178/530 (33%), Positives = 258/530 (48%), Gaps = 67/530 (12%)
Query: 147 CAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGK 206
C CK VH C + P + +++ ++ H WV + G+C C K
Sbjct: 235 CNLCKYTVHDQCA-------MKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQK 287
Query: 207 GFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRAR 266
+ +HS + + C WC H ++ LQ + C G+ ++PP+ I
Sbjct: 288 KIR---IYHS--LTGLHCVWC----HLEIHDDCLQAVGHECDCGLLRDHILPPSSIY--- 335
Query: 267 RPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQG 326
+ L + +K + + S K + +R P P PLLVFVNPKSGG QG
Sbjct: 336 --PSVLASGPDRKNS---KTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQG 390
Query: 327 AKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRL 386
+++ F + LNPRQVF+L + GP+ L +++ V + RIL CGGDGTVGWIL T+D+ L
Sbjct: 391 QRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANL 450
Query: 387 KPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEA 446
PPVA+LPLGTGNDLAR L WGGGY + ++KIL +E VV +DRW + P
Sbjct: 451 PVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP---- 506
Query: 447 GPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAF 506
+ E +D +P + NNYFS+G DA + FH RE PEKFNSR +NK++Y A
Sbjct: 507 ---QQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFAT 563
Query: 507 SDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD- 565
S+ + + K L + + V G L + +L + + LNIP G+ WG H
Sbjct: 564 SESIFSTCKKLEESLTVEICGKPL--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGD 621
Query: 566 ---------------FEPQ-------RHDDGYLEVIGFTMTSLAALQVG-------GHGE 596
+P D LEV+G A+++G G
Sbjct: 622 IYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGR 677
Query: 597 RLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRS 646
RL +C E+ T+K +P+Q+DGEP I+I +NQ M+ RS
Sbjct: 678 RLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRS 727
>gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 279 bits (713), Expect = 1e-74
Identities = 178/530 (33%), Positives = 258/530 (48%), Gaps = 67/530 (12%)
Query: 147 CAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGK 206
C CK VH C + P + +++ ++ H WV + G+C C K
Sbjct: 235 CNLCKYTVHDQCA-------MKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQK 287
Query: 207 GFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRAR 266
+ +HS + + C WC H ++ LQ + C G+ ++PP+ I
Sbjct: 288 KIR---IYHS--LTGLHCVWC----HLEIHDDCLQAVGHECDCGLLRDHILPPSSIY--- 335
Query: 267 RPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQG 326
+ L + +K + + S K + +R P P PLLVFVNPKSGG QG
Sbjct: 336 --PSVLASGPDRKNS---KTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQG 390
Query: 327 AKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRL 386
+++ F + LNPRQVF+L + GP+ L +++ V + RIL CGGDGTVGWIL T+D+ L
Sbjct: 391 QRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANL 450
Query: 387 KPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEA 446
PPVA+LPLGTGNDLAR L WGGGY + ++KIL +E VV +DRW + P
Sbjct: 451 PVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP---- 506
Query: 447 GPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAF 506
+ E +D +P + NNYFS+G DA + FH RE PEKFNSR +NK++Y A
Sbjct: 507 ---QQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFAT 563
Query: 507 SDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD- 565
S+ + + K L + + V G L + +L + + LNIP G+ WG H
Sbjct: 564 SESIFSTCKKLEESLTVEICGKPL--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGD 621
Query: 566 ---------------FEPQ-------RHDDGYLEVIGFTMTSLAALQVG-------GHGE 596
+P D LEV+G A+++G G
Sbjct: 622 IYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGR 677
Query: 597 RLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRS 646
RL +C E+ T+K +P+Q+DGEP I+I +NQ M+ RS
Sbjct: 678 RLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRS 727
>gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 279 bits (713), Expect = 1e-74
Identities = 178/530 (33%), Positives = 258/530 (48%), Gaps = 67/530 (12%)
Query: 147 CAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGK 206
C CK VH C + P + +++ ++ H WV + G+C C K
Sbjct: 235 CNLCKYTVHDQCA-------MKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQK 287
Query: 207 GFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRAR 266
+ +HS + + C WC H ++ LQ + C G+ ++PP+ I
Sbjct: 288 KIR---IYHS--LTGLHCVWC----HLEIHDDCLQAVGHECDCGLLRDHILPPSSIY--- 335
Query: 267 RPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQG 326
+ L + +K + + S K + +R P P PLLVFVNPKSGG QG
Sbjct: 336 --PSVLASGPDRKNS---KTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQG 390
Query: 327 AKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRL 386
+++ F + LNPRQVF+L + GP+ L +++ V + RIL CGGDGTVGWIL T+D+ L
Sbjct: 391 QRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANL 450
Query: 387 KPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEA 446
PPVA+LPLGTGNDLAR L WGGGY + ++KIL +E VV +DRW + P
Sbjct: 451 PVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP---- 506
Query: 447 GPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAF 506
+ E +D +P + NNYFS+G DA + FH RE PEKFNSR +NK++Y A
Sbjct: 507 ---QQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFAT 563
Query: 507 SDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD- 565
S+ + + K L + + V G L + +L + + LNIP G+ WG H
Sbjct: 564 SESIFSTCKKLEESLTVEICGKPL--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGD 621
Query: 566 ---------------FEPQ-------RHDDGYLEVIGFTMTSLAALQVG-------GHGE 596
+P D LEV+G A+++G G
Sbjct: 622 IYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGR 677
Query: 597 RLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRS 646
RL +C E+ T+K +P+Q+DGEP I+I +NQ M+ RS
Sbjct: 678 RLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRS 727
>gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 279 bits (713), Expect = 1e-74
Identities = 178/530 (33%), Positives = 258/530 (48%), Gaps = 67/530 (12%)
Query: 147 CAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGK 206
C CK VH C + P + +++ ++ H WV + G+C C K
Sbjct: 235 CNLCKYTVHDQCA-------MKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQK 287
Query: 207 GFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRAR 266
+ +HS + + C WC H ++ LQ + C G+ ++PP+ I
Sbjct: 288 KIR---IYHS--LTGLHCVWC----HLEIHDDCLQAVGHECDCGLLRDHILPPSSIY--- 335
Query: 267 RPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQG 326
+ L + +K + + S K + +R P P PLLVFVNPKSGG QG
Sbjct: 336 --PSVLASGPDRKNS---KTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQG 390
Query: 327 AKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRL 386
+++ F + LNPRQVF+L + GP+ L +++ V + RIL CGGDGTVGWIL T+D+ L
Sbjct: 391 QRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANL 450
Query: 387 KPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEA 446
PPVA+LPLGTGNDLAR L WGGGY + ++KIL +E VV +DRW + P
Sbjct: 451 PVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP---- 506
Query: 447 GPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAF 506
+ E +D +P + NNYFS+G DA + FH RE PEKFNSR +NK++Y A
Sbjct: 507 ---QQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFAT 563
Query: 507 SDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD- 565
S+ + + K L + + V G L + +L + + LNIP G+ WG H
Sbjct: 564 SESIFSTCKKLEESLTVEICGKPL--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGD 621
Query: 566 ---------------FEPQ-------RHDDGYLEVIGFTMTSLAALQVG-------GHGE 596
+P D LEV+G A+++G G
Sbjct: 622 IYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGR 677
Query: 597 RLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRS 646
RL +C E+ T+K +P+Q+DGEP I+I +NQ M+ RS
Sbjct: 678 RLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRS 727
>gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens]
Length = 752
Score = 270 bits (689), Expect = 6e-72
Identities = 149/365 (40%), Positives = 204/365 (55%), Gaps = 36/365 (9%)
Query: 306 PSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRI 365
P+P PLLV VNPKSGG QG +I++ F + LNP+QVF+L GGP L +R + R+
Sbjct: 389 PTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRV 448
Query: 366 LACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHV 425
LACGGDGTVGWIL +D+ PPVA+LPLGTGNDLAR L WGGGY ++KIL +
Sbjct: 449 LACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDI 508
Query: 426 EEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESRE 485
E+ +V LDRW L P E+ + G D++P + NNYFS+G DA + FH RE
Sbjct: 509 EQSPLVMLDRWHLEVIPR-----EEVENG--DQVPYSIMNNYFSIGVDASIAHRFHVMRE 561
Query: 486 ANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFL 545
+PEKFNSR +NK++Y S+ + K L HI + CDG+ + + ++ + + L
Sbjct: 562 KHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGV--DLSNIFLEGIAIL 619
Query: 546 NIPRYCAGTMPWGHPGEHH----------------DFEPQRHDDGYLEVIGFTMTSLAAL 589
NIP GT WG ++ F Q D LEV+G A+
Sbjct: 620 NIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLE----GAM 675
Query: 590 QVG-------GHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKA 642
++G G RL QC V + T+K +P+QVDGEP I+I +NQA M+
Sbjct: 676 EMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGP 735
Query: 643 KRRSA 647
++S+
Sbjct: 736 PQKSS 740
>gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens]
Length = 766
Score = 253 bits (646), Expect = 6e-67
Identities = 185/573 (32%), Positives = 260/573 (45%), Gaps = 108/573 (18%)
Query: 104 VDWSESATYGEHIW----FETNVSGDFCYVGEQYCVARMLKSVSRRK--CAACKIVVHTP 157
+D S S G H W F+ +FC++ ML V ++ C CK VH
Sbjct: 261 MDDSGSKGDGRHAWTMKHFKKPTYCNFCHI--------MLMGVRKQGLCCTYCKYTVHER 312
Query: 158 CIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSK 217
C+ R P ++ S+ R ++H WV KC C K + +
Sbjct: 313 CVS-------RNIPGCVKTYSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCY-----Q 359
Query: 218 EIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKK 277
+ A C WC+ +H K ++ C G ++ PT I R + K+
Sbjct: 360 SVTARHCVWCRMTFHRKC------ELSTLCDGGELRDHILLPTSICPITRDRPGEKSD-- 411
Query: 278 KKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYL 337
S KG +++ I PTP PLLV VNPKSGG QG
Sbjct: 412 -------GCVSAKGELVMQYK---IIPTPG--THPLLVLVNPKSGGRQG----------- 448
Query: 338 NPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPL 397
E L +R + R+LACGGDGTVGWIL +D+ PPVA+LPL
Sbjct: 449 --------------ERLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPL 494
Query: 398 GTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATD 457
GTGNDLAR L WGGGY ++KIL +E+ +V LDRW L P E+ + G D
Sbjct: 495 GTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPR-----EEVENG--D 547
Query: 458 RLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDL 517
++P + NNYFS+G DA + FH RE +PEKFNSR +NK++Y S+ + K L
Sbjct: 548 QVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKL 607
Query: 518 AKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHH------------- 564
HI + CDG+ + + ++ + + LNIP GT WG ++
Sbjct: 608 HDHIELECDGVGV--DLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDP 665
Query: 565 ---DFEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVLTTSKAIPV 614
F Q D LEV+G A+++G G RL QC V + T+K +P+
Sbjct: 666 KELKFCVQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPM 721
Query: 615 QVDGEPCKLAASRIRIALRNQATMVQKAKRRSA 647
QVDGEP I+I +NQA M+ ++S+
Sbjct: 722 QVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSS 754
>gi|40806175 diacylglycerol kinase, theta [Homo sapiens]
Length = 942
Score = 238 bits (606), Expect = 3e-62
Identities = 147/373 (39%), Positives = 205/373 (54%), Gaps = 21/373 (5%)
Query: 299 PFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYR 358
P ++ P PLLVFVNPKSGG +G ++ SF LNP QVFDL+ GGP L ++
Sbjct: 575 PDLLHAKLPPDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFS 634
Query: 359 KVHNLRILACGGDGTVGWILSTLDQLRLK---PPPPVAILPLGTGNDLARTLNWGGGYTD 415
+V R+L CGGDGTVGW+L L++ R + P P VAILPLGTGNDL R L WG GY+
Sbjct: 635 QVPCFRVLVCGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSG 694
Query: 416 EPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAH 475
E +L V+E + V +DRW + + + EAG + D + + +NY +G DA
Sbjct: 695 EDPFSVLLSVDEADAVLMDRWTILLDAH-EAGSAENDTADAEPPKIVQMSNYCGIGIDAE 753
Query: 476 VTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDL-TPKI 534
++L+FH++RE P KF SR NK Y + S+ L K IR+ + ++ P I
Sbjct: 754 LSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELPSI 811
Query: 535 QDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFT-MTSLAALQVG- 592
+ L +F+NIP + +G WG + FE R DDG LEV+G T + + +Q G
Sbjct: 812 EGL-----IFINIPSWGSGADLWGSDSDTR-FEKPRMDDGLLEVVGVTGVVHMGQVQGGL 865
Query: 593 GHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRI-ALRNQATMVQKAKRR-----S 646
G R+ Q +T KA PVQVDGEP A + I A + M++KAK++ +
Sbjct: 866 RSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGHMIISAAGPKVHMLRKAKQKPRRAGT 925
Query: 647 AAPLHSDQQPVPE 659
+D P PE
Sbjct: 926 TRDARADAAPAPE 938
>gi|4503313 diacylglycerol kinase epsilon [Homo sapiens]
Length = 567
Score = 217 bits (553), Expect = 4e-56
Identities = 180/611 (29%), Positives = 282/611 (46%), Gaps = 84/611 (13%)
Query: 44 EGSRGTAAGPPVEERFRQLHLRKQVSYRKAITKSGLQHLAPPPPTPGAPCSESERQIRST 103
E R A G P E F HL I + L P T S RQ+
Sbjct: 2 EAERRPAPGSPSEGLFADGHL---------ILWTLCSVLLPVFITFWCSLQRSRRQLHRR 52
Query: 104 VDWSESATYGEHIWFETNVSGD--FCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQ 161
+ +S +H W +T++ +C V C +L+ C C + V C+ +
Sbjct: 53 DIFRKS----KHGWRDTDLFSQPTYCCV----CAQHILQGAF---CDCCGLRVDEGCLRK 101
Query: 162 LEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVA 221
+K F+CK ++ ++ + + HHW+ R C +C QQ ++
Sbjct: 102 ADK-RFQCKEIMLKNDTKVLDA---MPHHWI--RGNVPLCSYCMVCKQQCGC--QPKLCD 153
Query: 222 ISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRA 281
C WC++ H + C E C G ++IPP+++ ++ +K K+
Sbjct: 154 YRCIWCQKTVHDE--CMKNSLKNEKCDFGEFKNLIIPPSYL-------TSINQMRKDKKT 204
Query: 282 SFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQ 341
++ +SK G + W P L++ N +SG N G ++ F LNP Q
Sbjct: 205 DYEVLASKLGKQ---WTP-------------LIILANSRSGTNMGEGLLGEFRILLNPVQ 248
Query: 342 VFDLSQGGPKEALEMYRKV--HNLRILACGGDGTVGWILSTLDQLRLKPP----PPVAIL 395
VFD+++ P +AL++ + ++ R+L CGGDGTVGW+L +D +++K P VA+L
Sbjct: 249 VFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVL 308
Query: 396 PLGTGNDLARTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEG 454
PLGTGNDL+ TL WG GY E PV+++L +V E + ++LDRW + ++G
Sbjct: 309 PLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVT----------NKG 358
Query: 455 ATD-RLPLD-VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMG 512
+ R P + NNYFS+G DA + L FH RE P F+SR NK Y D L+
Sbjct: 359 YYNLRKPKEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQ 418
Query: 513 SSKDLAKHIRVVCDGMDLT-PKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRH 571
KDL K + + DG + P ++ ++ LNI + G W G+ + RH
Sbjct: 419 ECKDLNKKVELELDGERVALPSLEG-----IIVLNIGYWGGGCRLWEGMGD-ETYPLARH 472
Query: 572 DDGYLEVIG-FTMTSLAALQVG-GHGERLTQCREV-VLTTSKAIPVQVDGEPCKLAASRI 628
DDG LEV+G + A +QV + R+ Q V ++ +P+QVDGEP +
Sbjct: 473 DDGLLEVVGVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTV 532
Query: 629 RIALRNQATMV 639
I + A M+
Sbjct: 533 TITHKTHAMML 543
>gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]
Length = 1164
Score = 152 bits (383), Expect = 2e-36
Identities = 108/333 (32%), Positives = 146/333 (43%), Gaps = 54/333 (16%)
Query: 113 GEHIWFE-TNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKP 171
G H W+ ++ FC V + +S C CK H C + CK
Sbjct: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLS---CEVCKFKAHKRCAVRATN---NCKW 227
Query: 172 SFRESGSRNVREP---TFVRHHWVHRRRQ-DGKCRHCGKGFQQKFTFHSKEIVAISCSWC 227
+ S +++ E + H W+ KC C K + C WC
Sbjct: 228 TTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWK-----CLWC 282
Query: 228 KQAYHSKVSCFMLQQIEEP-CSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRK 286
K H+ +C + + P C LG +IPP +
Sbjct: 283 KTMVHT--AC---KDLYHPICPLGQCKVSIIPPIAL----------------------NS 315
Query: 287 SSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLS 346
+ G R T S + PLLVFVN KSG NQG K ++ F LNP QVFDL
Sbjct: 316 TDSDG---------FCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLM 366
Query: 347 QGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLART 406
GGP L +++K N RIL CGGDG+VGW+LS +D+L L + +LPLGTGNDLAR
Sbjct: 367 NGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARV 426
Query: 407 LNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDL 438
L WGG Y D+ + +IL +E + LDRW +
Sbjct: 427 LGWGGSYDDDTQLPQILEKLERASTKMLDRWSI 459
Score = 105 bits (262), Expect = 2e-22
Identities = 65/184 (35%), Positives = 94/184 (51%), Gaps = 10/184 (5%)
Query: 463 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 522
V NNYF +G DA ++LEF+ RE +PEK SR +N M+Y + L S K+L + ++
Sbjct: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
Query: 523 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 581
+ CDG + P +Q + LNIP Y GT WG E F DD LEV+
Sbjct: 830 LECDGQYIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAI 884
Query: 582 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQAT 637
+M + + R+ QCR V +T + +PVQVDGE I+I +N+A
Sbjct: 885 FDSMQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQ 944
Query: 638 MVQK 641
M+ +
Sbjct: 945 MLTR 948
>gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]
Length = 1220
Score = 152 bits (383), Expect = 2e-36
Identities = 108/333 (32%), Positives = 146/333 (43%), Gaps = 54/333 (16%)
Query: 113 GEHIWFE-TNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKP 171
G H W+ ++ FC V + +S C CK H C + CK
Sbjct: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLS---CEVCKFKAHKRCAVRATN---NCKW 227
Query: 172 SFRESGSRNVREP---TFVRHHWVHRRRQ-DGKCRHCGKGFQQKFTFHSKEIVAISCSWC 227
+ S +++ E + H W+ KC C K + C WC
Sbjct: 228 TTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWK-----CLWC 282
Query: 228 KQAYHSKVSCFMLQQIEEP-CSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRK 286
K H+ +C + + P C LG +IPP +
Sbjct: 283 KTMVHT--AC---KDLYHPICPLGQCKVSIIPPIAL----------------------NS 315
Query: 287 SSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLS 346
+ G R T S + PLLVFVN KSG NQG K ++ F LNP QVFDL
Sbjct: 316 TDSDG---------FCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLM 366
Query: 347 QGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLART 406
GGP L +++K N RIL CGGDG+VGW+LS +D+L L + +LPLGTGNDLAR
Sbjct: 367 NGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARV 426
Query: 407 LNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDL 438
L WGG Y D+ + +IL +E + LDRW +
Sbjct: 427 LGWGGSYDDDTQLPQILEKLERASTKMLDRWSI 459
Score = 105 bits (262), Expect = 2e-22
Identities = 65/184 (35%), Positives = 94/184 (51%), Gaps = 10/184 (5%)
Query: 463 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 522
V NNYF +G DA ++LEF+ RE +PEK SR +N M+Y + L S K+L + ++
Sbjct: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
Query: 523 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 581
+ CDG + P +Q + LNIP Y GT WG E F DD LEV+
Sbjct: 830 LECDGQYIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAI 884
Query: 582 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQAT 637
+M + + R+ QCR V +T + +PVQVDGE I+I +N+A
Sbjct: 885 FDSMQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQ 944
Query: 638 MVQK 641
M+ +
Sbjct: 945 MLTR 948
>gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo
sapiens]
Length = 1170
Score = 150 bits (379), Expect = 5e-36
Identities = 100/299 (33%), Positives = 133/299 (44%), Gaps = 47/299 (15%)
Query: 147 CAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPT---FVRHHWVHRRRQ-DGKCR 202
C CK H C + CK + S +++ E + H W+ KC
Sbjct: 150 CEVCKFKAHKRCAVRATN---NCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCT 206
Query: 203 HCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI 262
C K C WCK H+ +L + C LG+ VIPPT +
Sbjct: 207 VCDKTCGSVLRLQDWR-----CLWCKAMVHTSCKESLLTK----CPLGLCKVSVIPPTAL 257
Query: 263 LRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSG 322
N++ + +G W+ P PLLVFVN KSG
Sbjct: 258 -------NSIDS-------------------DGFWKA----SCPPSCTSPLLVFVNSKSG 287
Query: 323 GNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLD 382
NQG K ++ F LNP QVFDL GGP L +++K RIL CGGDG+VGW+LS +D
Sbjct: 288 DNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEID 347
Query: 383 QLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHA 440
L L + +LPLGTGNDLAR L WG D+ + +IL +E + LDRW + A
Sbjct: 348 SLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMA 406
Score = 99.4 bits (246), Expect = 1e-20
Identities = 78/279 (27%), Positives = 124/279 (44%), Gaps = 25/279 (8%)
Query: 463 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 522
V NNYF +G DA ++L+F+ R+ +PEK SR +N M+Y + L + K+L + +
Sbjct: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
Query: 523 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 581
+ CDG + P +Q + LNIP Y GT WG E F DD LEV+
Sbjct: 779 LECDGRPIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAV 833
Query: 582 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQA- 636
+M + + R+ QCR V ++ + +PVQVDGE IRI +N+A
Sbjct: 834 FGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQ 893
Query: 637 TMVQKAKRRSAAPLHSDQQ----PVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGT 692
T+ + S D+Q P P S+H + Q+ + G
Sbjct: 894 TLTRDRAFESTLKSWEDKQKCELPRPPS-------CSLHPEMLSEEEATQMDQFGQAAGV 946
Query: 693 VVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPK 731
++ S E+ ++H + Q+ A S + ++ K
Sbjct: 947 LI---HSIREIAQSHRDMEQELAHAVNASSKSMDRVYGK 982
>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
sapiens]
Length = 1214
Score = 150 bits (379), Expect = 5e-36
Identities = 100/299 (33%), Positives = 133/299 (44%), Gaps = 47/299 (15%)
Query: 147 CAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPT---FVRHHWVHRRRQ-DGKCR 202
C CK H C + CK + S +++ E + H W+ KC
Sbjct: 194 CEVCKFKAHKRCAVRATN---NCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCT 250
Query: 203 HCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI 262
C K C WCK H+ +L + C LG+ VIPPT +
Sbjct: 251 VCDKTCGSVLRLQDWR-----CLWCKAMVHTSCKESLLTK----CPLGLCKVSVIPPTAL 301
Query: 263 LRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSG 322
N++ + +G W+ P PLLVFVN KSG
Sbjct: 302 -------NSIDS-------------------DGFWKA----SCPPSCTSPLLVFVNSKSG 331
Query: 323 GNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLD 382
NQG K ++ F LNP QVFDL GGP L +++K RIL CGGDG+VGW+LS +D
Sbjct: 332 DNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEID 391
Query: 383 QLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHA 440
L L + +LPLGTGNDLAR L WG D+ + +IL +E + LDRW + A
Sbjct: 392 SLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMA 450
Score = 99.4 bits (246), Expect = 1e-20
Identities = 78/279 (27%), Positives = 124/279 (44%), Gaps = 25/279 (8%)
Query: 463 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 522
V NNYF +G DA ++L+F+ R+ +PEK SR +N M+Y + L + K+L + +
Sbjct: 763 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 822
Query: 523 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 581
+ CDG + P +Q + LNIP Y GT WG E F DD LEV+
Sbjct: 823 LECDGRPIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAV 877
Query: 582 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQA- 636
+M + + R+ QCR V ++ + +PVQVDGE IRI +N+A
Sbjct: 878 FGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQ 937
Query: 637 TMVQKAKRRSAAPLHSDQQ----PVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGT 692
T+ + S D+Q P P S+H + Q+ + G
Sbjct: 938 TLTRDRAFESTLKSWEDKQKCELPRPPS-------CSLHPEMLSEEEATQMDQFGQAAGV 990
Query: 693 VVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPK 731
++ S E+ ++H + Q+ A S + ++ K
Sbjct: 991 LI---HSIREIAQSHRDMEQELAHAVNASSKSMDRVYGK 1026
>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
Length = 1271
Score = 134 bits (336), Expect = 5e-31
Identities = 78/226 (34%), Positives = 107/226 (47%), Gaps = 28/226 (12%)
Query: 224 CSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASF 283
C WC H ++ + C H + VIPPT + + + +S
Sbjct: 430 CLWCNSTVHDDCR----RRFSKECCFRSHRSSVIPPTALSDPKGDGQLVVSSD------- 478
Query: 284 KRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVF 343
F S PLL+F+N KSG +QG ++ F YLNP QVF
Sbjct: 479 ----------------FWNLDWSSACSCPLLIFINSKSGDHQGIVFLRKFKQYLNPSQVF 522
Query: 344 DLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDL 403
DL +GGP+ L M++ RIL CGGDG+V W+LS +D L +A++PLGTGNDL
Sbjct: 523 DLLKGGPEAGLSMFKNFARFRILVCGGDGSVSWVLSLIDAFGLHEKCQLAVIPLGTGNDL 582
Query: 404 ARTLNWGGGYT-DEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGP 448
AR L WG + + IL+ VE+ +V LDRW + P P
Sbjct: 583 ARVLGWGAFWNKSKSPLDILNRVEQASVRILDRWSVMIRETPRQTP 628
Score = 110 bits (275), Expect = 6e-24
Identities = 73/223 (32%), Positives = 114/223 (51%), Gaps = 16/223 (7%)
Query: 463 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 522
V NNYF +G DA ++L+F+ R+ +P ++NSR +NKM+Y + L S + L + +
Sbjct: 857 VMNNYFGIGLDAKISLDFNTRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSYRKLEERVH 916
Query: 523 VVCDGMDLT-PKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 581
+ CDG ++ P +Q +V LNI Y G WG ++E DDG LEV+
Sbjct: 917 LECDGETISLPNLQG-----IVVLNITSYAGGINFWGSNTATTEYEAPAIDDGKLEVVAI 971
Query: 582 TMTSLAALQ--VGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQAT 637
+ A+ + H R+ QC EV++T + IPVQVDGE I+I +N A
Sbjct: 972 FGSVQMAMSRIINLHHHRIAQCHEVMITIDGEEGIPVQVDGEAWIQRPGLIKIRYKNAAQ 1031
Query: 638 MVQKAK-----RRSAAPLHSDQQPVPE-QLRIQVSRVSMHDYE 674
M+ + + + H++ Q P+ QL Q S+ S+ D E
Sbjct: 1032 MLTRDRDFENSMKMWEYKHTEIQAAPQPQLDFQDSQESLSDEE 1074
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 57.4 bits (137), Expect = 6e-08
Identities = 41/117 (35%), Positives = 54/117 (46%), Gaps = 2/117 (1%)
Query: 811 LIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDA 870
L++A R + +L R G + RD RT LH AV G +VR LL P + A
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAP--VGA 102
Query: 871 VEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYL 927
V+ G T LH+AA G + +++ GAS G TP A T LAA L
Sbjct: 103 VDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARL 159
Score = 43.5 bits (101), Expect = 0.001
Identities = 38/121 (31%), Positives = 51/121 (42%), Gaps = 4/121 (3%)
Query: 811 LIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDH-APPEILD 869
L+ AA L+ L G + RD T L A + G + LL H A P I D
Sbjct: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
Query: 870 AVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLEN 929
+G + LH+AAA G +V GA + D G TP A + E+A L +
Sbjct: 267 ---RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLD 323
Query: 930 R 930
R
Sbjct: 324 R 324
Score = 32.3 bits (72), Expect = 2.1
Identities = 24/82 (29%), Positives = 36/82 (43%), Gaps = 2/82 (2%)
Query: 830 GGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRT 889
G D RD R+ LH A + G V+ L+ +DA + G T LH A+ G
Sbjct: 259 GADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAE--VDARDTLGLTPLHHASREGHVE 316
Query: 890 ICHYIVEAGASLMKTDQQGDTP 911
+ +++ GA + T TP
Sbjct: 317 VAGCLLDRGAQVDATGWLRKTP 338
>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
Length = 300
Score = 53.5 bits (127), Expect = 9e-07
Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 4/109 (3%)
Query: 809 EELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDH-APPEI 867
+ L ++A ND +Q+L G D D++ RT LH A G+ +V+ LLDH A P
Sbjct: 112 KRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQ 171
Query: 868 LDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAE 916
D + G T LH AA + ++ GA + D+ G TP A+
Sbjct: 172 RDGL---GNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK 217
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 53.1 bits (126), Expect = 1e-06
Identities = 36/114 (31%), Positives = 55/114 (48%), Gaps = 2/114 (1%)
Query: 814 AAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEE 873
AA++ + ++ L G D+ D+Q RT L A G V +LL L ++++
Sbjct: 1111 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAA--LSSLDK 1168
Query: 874 NGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYL 927
G + L A G R + Y+VE GA++ +TD+ G TP A D E YL
Sbjct: 1169 EGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYL 1222
Score = 46.6 bits (109), Expect = 1e-04
Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 2/117 (1%)
Query: 811 LIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDA 870
L+ AA ++ L G L D++ + L A G + VV+YL++ +D
Sbjct: 1141 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAA--IDQ 1198
Query: 871 VEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYL 927
++NG T L AA G Y+VE GA + D G P RA ++T + L
Sbjct: 1199 TDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVAL 1255
Score = 32.0 bits (71), Expect = 2.8
Identities = 31/129 (24%), Positives = 51/129 (39%), Gaps = 43/129 (33%)
Query: 826 LHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLL----------------DHAPPEILD 869
L + G + H D++ + L H+ G D+++YLL HA + L
Sbjct: 979 LTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALT 1038
Query: 870 A---------------------VEENG------ETCLHQAAALGQRTICHYIVEAGASLM 902
A VE NG ET L AA G+ +C ++ GA++
Sbjct: 1039 AAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVS 1098
Query: 903 KTDQQGDTP 911
+T+++G P
Sbjct: 1099 RTNRRGVPP 1107
Score = 30.4 bits (67), Expect = 8.1
Identities = 19/58 (32%), Positives = 28/58 (48%), Gaps = 2/58 (3%)
Query: 851 GSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQG 908
G ++VV LL+ LD ENG T L AAA G + + + G + D++G
Sbjct: 938 GHEEVVTLLLEFGA--CLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKG 993
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 53.1 bits (126), Expect = 1e-06
Identities = 36/114 (31%), Positives = 55/114 (48%), Gaps = 2/114 (1%)
Query: 814 AAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEE 873
AA++ + ++ L G D+ D+Q RT L A G V +LL L ++++
Sbjct: 1119 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAA--LSSLDK 1176
Query: 874 NGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYL 927
G + L A G R + Y+VE GA++ +TD+ G TP A D E YL
Sbjct: 1177 EGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYL 1230
Score = 46.6 bits (109), Expect = 1e-04
Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 2/117 (1%)
Query: 811 LIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDA 870
L+ AA ++ L G L D++ + L A G + VV+YL++ +D
Sbjct: 1149 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAA--IDQ 1206
Query: 871 VEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYL 927
++NG T L AA G Y+VE GA + D G P RA ++T + L
Sbjct: 1207 TDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVAL 1263
Score = 32.0 bits (71), Expect = 2.8
Identities = 31/129 (24%), Positives = 51/129 (39%), Gaps = 43/129 (33%)
Query: 826 LHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLL----------------DHAPPEILD 869
L + G + H D++ + L H+ G D+++YLL HA + L
Sbjct: 987 LTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALT 1046
Query: 870 A---------------------VEENG------ETCLHQAAALGQRTICHYIVEAGASLM 902
A VE NG ET L AA G+ +C ++ GA++
Sbjct: 1047 AAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVS 1106
Query: 903 KTDQQGDTP 911
+T+++G P
Sbjct: 1107 RTNRRGVPP 1115
Score = 30.4 bits (67), Expect = 8.1
Identities = 19/58 (32%), Positives = 28/58 (48%), Gaps = 2/58 (3%)
Query: 851 GSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQG 908
G ++VV LL+ LD ENG T L AAA G + + + G + D++G
Sbjct: 946 GHEEVVTLLLEFGA--CLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKG 1001
>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 50.8 bits (120), Expect = 6e-06
Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 2/124 (1%)
Query: 808 GEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEI 867
G + A D ++ +L G D+ + + T LH A + D+V++L+++
Sbjct: 41 GAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGAN-- 98
Query: 868 LDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYL 927
++ + G LH AA+ G I +++ GA + + +GDTP AE+ EL
Sbjct: 99 INQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNE 158
Query: 928 ENRQ 931
NRQ
Sbjct: 159 VNRQ 162
Score = 33.5 bits (75), Expect = 0.96
Identities = 33/140 (23%), Positives = 62/140 (44%), Gaps = 12/140 (8%)
Query: 807 QGEELIEAAKRNDFCKLQELHR---AG--GDLMHRDEQSRTLLHHAVSTGSKDVVRYLLD 861
QG ++ A K + L++ + +G D+ H + T LH A + G +V++ L+
Sbjct: 162 QGVDIEAARKEEERIMLRDARQWLNSGHINDVRHA-KSGGTALHVAAAKGYTEVLKLLIQ 220
Query: 862 HAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDT 921
++ + +G T LH AA G+ C +V+ + ++ G T A D
Sbjct: 221 AGYD--VNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT----AFDVADE 274
Query: 922 ELAAYLENRQHYQMIQREDQ 941
++ YLE Q Q + ++
Sbjct: 275 DILGYLEELQKKQNLLHSEK 294
Score = 32.0 bits (71), Expect = 2.8
Identities = 31/111 (27%), Positives = 50/111 (45%), Gaps = 23/111 (20%)
Query: 809 EELIEAAKRNDFCKLQELHRAGGDL-MHRDEQSRTLLHHA---VSTGSKDVVRYLLDHAP 864
EE +E +N E++R G D+ R E+ R +L A +++G + VR+
Sbjct: 148 EEAMEELLQN------EVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHA----- 196
Query: 865 PEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRA 915
++G T LH AAA G + +++AG + D G TP A
Sbjct: 197 --------KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAA 239
>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 50.8 bits (120), Expect = 6e-06
Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 2/124 (1%)
Query: 808 GEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEI 867
G + A D ++ +L G D+ + + T LH A + D+V++L+++
Sbjct: 41 GAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGAN-- 98
Query: 868 LDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYL 927
++ + G LH AA+ G I +++ GA + + +GDTP AE+ EL
Sbjct: 99 INQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNE 158
Query: 928 ENRQ 931
NRQ
Sbjct: 159 VNRQ 162
Score = 33.5 bits (75), Expect = 0.96
Identities = 33/140 (23%), Positives = 62/140 (44%), Gaps = 12/140 (8%)
Query: 807 QGEELIEAAKRNDFCKLQELHR---AG--GDLMHRDEQSRTLLHHAVSTGSKDVVRYLLD 861
QG ++ A K + L++ + +G D+ H + T LH A + G +V++ L+
Sbjct: 162 QGVDIEAARKEEERIMLRDARQWLNSGHINDVRHA-KSGGTALHVAAAKGYTEVLKLLIQ 220
Query: 862 HAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDT 921
++ + +G T LH AA G+ C +V+ + ++ G T A D
Sbjct: 221 AGYD--VNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT----AFDVADE 274
Query: 922 ELAAYLENRQHYQMIQREDQ 941
++ YLE Q Q + ++
Sbjct: 275 DILGYLEELQKKQNLLHSEK 294
Score = 32.0 bits (71), Expect = 2.8
Identities = 31/111 (27%), Positives = 50/111 (45%), Gaps = 23/111 (20%)
Query: 809 EELIEAAKRNDFCKLQELHRAGGDL-MHRDEQSRTLLHHA---VSTGSKDVVRYLLDHAP 864
EE +E +N E++R G D+ R E+ R +L A +++G + VR+
Sbjct: 148 EEAMEELLQN------EVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHA----- 196
Query: 865 PEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRA 915
++G T LH AAA G + +++AG + D G TP A
Sbjct: 197 --------KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAA 239
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 50.4 bits (119), Expect = 8e-06
Identities = 43/155 (27%), Positives = 72/155 (46%), Gaps = 11/155 (7%)
Query: 771 LLGASARPDLP--TPTSPLPTSPC---SPTPRSLQGDAAPPQGEE----LIEAAKRNDFC 821
L+ +AR + P TP P T+P +P+ S Q D + E L AA R D
Sbjct: 117 LMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVK 176
Query: 822 KLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQ 881
+++EL G ++ +D T LH A + G DV + L+ +++ +T LH
Sbjct: 177 QVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDD--DTPLHD 234
Query: 882 AAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAE 916
+A+ G R I ++ G + + ++ G+ P AE
Sbjct: 235 SASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAE 269
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 50.4 bits (119), Expect = 8e-06
Identities = 43/155 (27%), Positives = 72/155 (46%), Gaps = 11/155 (7%)
Query: 771 LLGASARPDLP--TPTSPLPTSPC---SPTPRSLQGDAAPPQGEE----LIEAAKRNDFC 821
L+ +AR + P TP P T+P +P+ S Q D + E L AA R D
Sbjct: 140 LMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVK 199
Query: 822 KLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQ 881
+++EL G ++ +D T LH A + G DV + L+ +++ +T LH
Sbjct: 200 QVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDD--DTPLHD 257
Query: 882 AAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAE 916
+A+ G R I ++ G + + ++ G+ P AE
Sbjct: 258 SASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAE 292
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 50.4 bits (119), Expect = 8e-06
Identities = 41/131 (31%), Positives = 65/131 (49%), Gaps = 11/131 (8%)
Query: 799 LQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSR--TLLHHAVSTGSKDVV 856
L+GDAA L++AAK+ ++Q+L ++ RD Q R T LH A + +V
Sbjct: 801 LRGDAA------LLDAAKKGCLARVQKLCTPE-NINCRDTQGRNSTPLHLAAGYNNLEVA 853
Query: 857 RYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAE 916
YLL+H ++A ++ G LH AA+ G I +++ + TD+ TP A
Sbjct: 854 EYLLEHGAD--VNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAA 911
Query: 917 KAQDTELAAYL 927
+ T+L A L
Sbjct: 912 QKGRTQLCALL 922
Score = 48.1 bits (113), Expect = 4e-05
Identities = 50/177 (28%), Positives = 80/177 (45%), Gaps = 12/177 (6%)
Query: 747 DRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPP 806
+ Q+ L+ T I ++ D LL AS DL T + + R L+G + P
Sbjct: 633 EAVQQILSESTPIRTSDV---DYRLLEASKAGDLETVKQLCSSQ--NVNCRDLEGRHSTP 687
Query: 807 QGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPE 866
L AA N ++ L G D+ +D+ LH+A S G +V L+ H
Sbjct: 688 ----LHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGAS- 742
Query: 867 ILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTEL 923
++ + T LH+AAA G+ IC +++ GA K ++ G+TP K DT++
Sbjct: 743 -VNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDI 797
Score = 42.4 bits (98), Expect = 0.002
Identities = 33/115 (28%), Positives = 54/115 (46%), Gaps = 6/115 (5%)
Query: 797 RSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVV 856
R QG + P L AA N+ + L G D+ +D+ LH+A S G D+
Sbjct: 831 RDTQGRNSTP----LHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIA 886
Query: 857 RYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTP 911
L+ + ++A ++ T LH+AA G+ +C ++ GA +Q+G TP
Sbjct: 887 ALLIKYNT--CVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTP 939
Score = 40.8 bits (94), Expect = 0.006
Identities = 26/93 (27%), Positives = 42/93 (45%), Gaps = 2/93 (2%)
Query: 826 LHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAAL 885
L R G ++ +++ T LH A DV+ L H ++A++ G+T LH+AA
Sbjct: 544 LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK--MNALDTLGQTALHRAALA 601
Query: 886 GQRTICHYIVEAGASLMKTDQQGDTPRQRAEKA 918
G C ++ G+ QG T Q +A
Sbjct: 602 GHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEA 634
Score = 40.0 bits (92), Expect = 0.010
Identities = 35/119 (29%), Positives = 52/119 (43%), Gaps = 5/119 (4%)
Query: 811 LIEAAKRNDFCKLQELHRAGGDLMHRDEQSR--TLLHHAVSTGSKDVVRYLLDHAPPEIL 868
L+EA+K D +++L + ++ RD + R T LH A VV YLL H +
Sbjct: 654 LLEASKAGDLETVKQLC-SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGAD--V 710
Query: 869 DAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYL 927
A ++ G LH A + G + +V GAS+ D TP A E+ L
Sbjct: 711 HAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLL 769
Score = 38.5 bits (88), Expect = 0.030
Identities = 41/159 (25%), Positives = 63/159 (39%), Gaps = 28/159 (17%)
Query: 782 TPTSPLPTSPCSP------TPRSLQGDAAPPQG-----------------EELIEAAKRN 818
+PTS +SP SP +P + + P G EL+EA +
Sbjct: 134 SPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNG 193
Query: 819 DFCKLQELHRAGGDLMHRDEQSR--TLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGE 876
D +++ L A ++ +D R + LH A G KDVV +LL + A ++ G
Sbjct: 194 DVSRVKRLVDAA-NVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGAN--VHARDDGGL 250
Query: 877 TCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRA 915
LH A + G + ++ GA D TP A
Sbjct: 251 IPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEA 289
Score = 35.0 bits (79), Expect = 0.33
Identities = 26/86 (30%), Positives = 43/86 (50%), Gaps = 2/86 (2%)
Query: 814 AAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEE 873
AA N +Q L + G D+ +D+ LH+A S G +V LL H ++A++
Sbjct: 376 AAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHG--ACVNAMDL 433
Query: 874 NGETCLHQAAALGQRTICHYIVEAGA 899
T LH+AA+ + +C ++ GA
Sbjct: 434 WQFTPLHEAASKNRVEVCSLLLSHGA 459
Score = 33.9 bits (76), Expect = 0.74
Identities = 25/78 (32%), Positives = 41/78 (52%), Gaps = 4/78 (5%)
Query: 823 LQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLL-DHAPPEILDAVEENGETCLHQ 881
++ L + G ++ RD+ LH+A S G +VV LL A P +A + T LH+
Sbjct: 232 VEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADP---NARDNWNYTPLHE 288
Query: 882 AAALGQRTICHYIVEAGA 899
AA G+ +C +++ GA
Sbjct: 289 AAIKGKIDVCIVLLQHGA 306
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,752,990
Number of Sequences: 37866
Number of extensions: 2250151
Number of successful extensions: 18903
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 362
Number of HSP's successfully gapped in prelim test: 473
Number of HSP's that attempted gapping in prelim test: 12720
Number of HSP's gapped (non-prelim): 5874
length of query: 945
length of database: 18,247,518
effective HSP length: 112
effective length of query: 833
effective length of database: 14,006,526
effective search space: 11667436158
effective search space used: 11667436158
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.