Search of human proteins with 40068475

Search of human proteins with 40068475

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40068475 twinfilin 1 [Homo sapiens]
         (384 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40068475 twinfilin 1 [Homo sapiens]                                771   0.0  
gi|6005846 twinfilin-like protein [Homo sapiens]                      489   e-138
gi|5031635 cofilin 1 (non-muscle) [Homo sapiens]                       45   8e-05
gi|4758440 glia maturation factor, gamma [Homo sapiens]                43   4e-04
gi|14719392 cofilin 2 [Homo sapiens]                                   43   5e-04
gi|33946278 cofilin 2 [Homo sapiens]                                   43   5e-04
gi|58530848 destrin isoform b [Homo sapiens]                           39   0.008
gi|5802966 destrin isoform a [Homo sapiens]                            39   0.008
gi|169165465 PREDICTED: similar to Destrin (actin depolymerizing...    33   0.33 
gi|113415024 PREDICTED: similar to destrin [Homo sapiens]              33   0.33 
gi|169165083 PREDICTED: similar to Destrin (actin depolymerizing...    33   0.33 
gi|218749820 hypothetical protein LOC84221 isoform 1 [Homo sapiens]    31   2.1  
gi|23346427 hypothetical protein LOC84221 isoform 2 [Homo sapiens]     31   2.1  
gi|22749337 THAP domain containing 8 [Homo sapiens]                    30   4.8  
gi|7661950 SH2 domain binding protein 1 [Homo sapiens]                 30   4.8  

>gi|40068475 twinfilin 1 [Homo sapiens]
          Length = 384

 Score =  771 bits (1991), Expect = 0.0
 Identities = 384/384 (100%), Positives = 384/384 (100%)

Query: 1   MTRRGRRRSSHFLGPPAGAAGCTQRRSRELAAAAMSHQTGIQASEDVKEIFARARNGKYR 60
           MTRRGRRRSSHFLGPPAGAAGCTQRRSRELAAAAMSHQTGIQASEDVKEIFARARNGKYR
Sbjct: 1   MTRRGRRRSSHFLGPPAGAAGCTQRRSRELAAAAMSHQTGIQASEDVKEIFARARNGKYR 60

Query: 61  LLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPLLEDKQPCYILFRLDSQNAQGYEWIFI 120
           LLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPLLEDKQPCYILFRLDSQNAQGYEWIFI
Sbjct: 61  LLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPLLEDKQPCYILFRLDSQNAQGYEWIFI 120

Query: 121 AWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYKKYLLSQSSPAP 180
           AWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYKKYLLSQSSPAP
Sbjct: 121 AWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYKKYLLSQSSPAP 180

Query: 181 LTAAEEELRQIKINEVQTDVGVDTKHQTLQGVAFPISREAFQALEKLNNRQLNYVQLEID 240
           LTAAEEELRQIKINEVQTDVGVDTKHQTLQGVAFPISREAFQALEKLNNRQLNYVQLEID
Sbjct: 181 LTAAEEELRQIKINEVQTDVGVDTKHQTLQGVAFPISREAFQALEKLNNRQLNYVQLEID 240

Query: 241 IKNEIIILANTTNTELKDLPKRIPKDSARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSI 300
           IKNEIIILANTTNTELKDLPKRIPKDSARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSI
Sbjct: 241 IKNEIIILANTTNTELKDLPKRIPKDSARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSI 300

Query: 301 RERMLYSSCKSRLLEIVERQLQMDVIRKIEIDNGDELTADFLYEEVHPKQHAHKQSFAKP 360
           RERMLYSSCKSRLLEIVERQLQMDVIRKIEIDNGDELTADFLYEEVHPKQHAHKQSFAKP
Sbjct: 301 RERMLYSSCKSRLLEIVERQLQMDVIRKIEIDNGDELTADFLYEEVHPKQHAHKQSFAKP 360

Query: 361 KGPAGKRGIRRLIRGPAETEATTD 384
           KGPAGKRGIRRLIRGPAETEATTD
Sbjct: 361 KGPAGKRGIRRLIRGPAETEATTD 384


>gi|6005846 twinfilin-like protein [Homo sapiens]
          Length = 349

 Score =  489 bits (1258), Expect = e-138
 Identities = 225/344 (65%), Positives = 294/344 (85%)

Query: 35  MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPL 94
           M+HQTGI A+E++KE FA+AR G  RL+K+ IE+EQLV+G+  +P   WD+DYD  VLPL
Sbjct: 1   MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWDQDYDRAVLPL 60

Query: 95  LEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDE 154
           L+ +QPCY+L+RLDSQNAQG+EW+F+AWSPD+S VR KMLYAATRAT+KKEFGGGHIKDE
Sbjct: 61  LDAQQPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDE 120

Query: 155 VFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVGVDTKHQTLQGVAF 214
           +FGTVK+D+S  GY+K+L S ++PAPLT+AE EL+QI+INEV+T++ V++KHQTLQG+AF
Sbjct: 121 LFGTVKDDLSFAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAF 180

Query: 215 PISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDSARYHFFL 274
           P+  EA +AL++L  + +NY+Q+++D++ E I L +T  T++  LP R+P+D+ARYHFFL
Sbjct: 181 PLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPTDVAQLPSRVPRDAARYHFFL 240

Query: 275 YKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIRKIEIDNG 334
           YKH+HEGD LES+VFIYSMPGY CSI+ERMLYSSCKSRLL+ VE+   +++ +KIEI +G
Sbjct: 241 YKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAKKIEIGDG 300

Query: 335 DELTADFLYEEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAE 378
            ELTA+FLY+EVHPKQHA KQ+FAKPKGP GKRG +RLIRGP E
Sbjct: 301 AELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRGHKRLIRGPGE 344


>gi|5031635 cofilin 1 (non-muscle) [Homo sapiens]
          Length = 166

 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 28/99 (28%), Positives = 56/99 (56%), Gaps = 8/99 (8%)

Query: 67  ENEQLVIGSYSQPSDSWDKDYDSFVLPLLEDKQPCYILF--RLDSQNAQGYEWIFIAWSP 124
           E +++++G   Q  D     Y +FV  +L DK   Y L+    +++ ++  + +FI W+P
Sbjct: 51  EGKEILVGDVGQTVDD---PYATFV-KMLPDKDCRYALYDATYETKESKKEDLVFIFWAP 106

Query: 125 DHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDV 163
           + + ++ KM+YA+++  +KK+  G  IK E+     E+V
Sbjct: 107 ESAPLKSKMIYASSKDAIKKKLTG--IKHELQANCYEEV 143


>gi|4758440 glia maturation factor, gamma [Homo sapiens]
          Length = 142

 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 28/112 (25%), Positives = 58/112 (51%), Gaps = 9/112 (8%)

Query: 237 LEIDIKNEIIILANT-TNTELKDLPKRIPKDSARYHFFLYKHSHE-GDYLESIVFIYSMP 294
           +++D   ++++L     N   ++L   +P+   R+  + YK+ H+ G     + FI+S P
Sbjct: 34  MKVDKDRQMVVLEEEFQNISPEELKMELPERQPRFVVYSYKYVHDDGRVSYPLCFIFSSP 93

Query: 295 GYTCSIRERMLYSSCKSRLLEIVERQLQMDVIRKIEIDNGDELTADFLYEEV 346
              C   ++M+Y+  K+RL++  E      + +  EI   D+LT  +L E++
Sbjct: 94  -VGCKPEQQMMYAGSKNRLVQTAE------LTKVFEIRTTDDLTEAWLQEKL 138


>gi|14719392 cofilin 2 [Homo sapiens]
          Length = 166

 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 24/84 (28%), Positives = 50/84 (59%), Gaps = 6/84 (7%)

Query: 67  ENEQLVIGSYSQPSDSWDKDYDSFV--LPLLEDKQPCYILFRLDSQNAQGYEWIFIAWSP 124
           E +Q+++G      D+ +  Y SFV  LPL + +   Y     +++ ++  + +FI W+P
Sbjct: 51  EAKQILVGDIG---DTVEDPYTSFVKLLPLNDCRYALYDA-TYETKESKKEDLVFIFWAP 106

Query: 125 DHSHVRQKMLYAATRATLKKEFGG 148
           + + ++ KM+YA+++  +KK+F G
Sbjct: 107 ESAPLKSKMIYASSKDAIKKKFTG 130


>gi|33946278 cofilin 2 [Homo sapiens]
          Length = 166

 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 24/84 (28%), Positives = 50/84 (59%), Gaps = 6/84 (7%)

Query: 67  ENEQLVIGSYSQPSDSWDKDYDSFV--LPLLEDKQPCYILFRLDSQNAQGYEWIFIAWSP 124
           E +Q+++G      D+ +  Y SFV  LPL + +   Y     +++ ++  + +FI W+P
Sbjct: 51  EAKQILVGDIG---DTVEDPYTSFVKLLPLNDCRYALYDA-TYETKESKKEDLVFIFWAP 106

Query: 125 DHSHVRQKMLYAATRATLKKEFGG 148
           + + ++ KM+YA+++  +KK+F G
Sbjct: 107 ESAPLKSKMIYASSKDAIKKKFTG 130


>gi|58530848 destrin isoform b [Homo sapiens]
          Length = 148

 Score = 38.9 bits (89), Expect = 0.008
 Identities = 21/73 (28%), Positives = 43/73 (58%), Gaps = 4/73 (5%)

Query: 94  LLEDKQPCYILF--RLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHI 151
           +L +K   Y L+    +++ ++  E +F  W+P+ + ++ KM+YA+++  +KK+F G  I
Sbjct: 57  MLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQG--I 114

Query: 152 KDEVFGTVKEDVS 164
           K E      ED++
Sbjct: 115 KHECQANGPEDLN 127


>gi|5802966 destrin isoform a [Homo sapiens]
          Length = 165

 Score = 38.9 bits (89), Expect = 0.008
 Identities = 21/73 (28%), Positives = 43/73 (58%), Gaps = 4/73 (5%)

Query: 94  LLEDKQPCYILF--RLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHI 151
           +L +K   Y L+    +++ ++  E +F  W+P+ + ++ KM+YA+++  +KK+F G  I
Sbjct: 74  MLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQG--I 131

Query: 152 KDEVFGTVKEDVS 164
           K E      ED++
Sbjct: 132 KHECQANGPEDLN 144


>gi|169165465 PREDICTED: similar to Destrin (actin depolymerizing
           factor) [Homo sapiens]
          Length = 252

 Score = 33.5 bits (75), Expect = 0.33
 Identities = 18/78 (23%), Positives = 38/78 (48%), Gaps = 5/78 (6%)

Query: 94  LLEDKQPCYILFRLDSQNAQGYEWIFIA---WSPDHSHVRQKMLYAATRATLKKEFGGGH 150
           +L +K  CY L+    +  +    +F+    W+P+   ++ KM++ + +  +KK+F    
Sbjct: 167 MLPEKDCCYALYDASFETKKSGRVLFVCLFLWAPELPPLKSKMIFTSCKDAIKKKFQANG 226

Query: 151 IKDEVFGTVKEDVSLHGY 168
            +D  +  + E   L GY
Sbjct: 227 PEDLNWACIAE--KLDGY 242


>gi|113415024 PREDICTED: similar to destrin [Homo sapiens]
          Length = 199

 Score = 33.5 bits (75), Expect = 0.33
 Identities = 18/78 (23%), Positives = 38/78 (48%), Gaps = 5/78 (6%)

Query: 94  LLEDKQPCYILFRLDSQNAQGYEWIFIA---WSPDHSHVRQKMLYAATRATLKKEFGGGH 150
           +L +K  CY L+    +  +    +F+    W+P+   ++ KM++ + +  +KK+F    
Sbjct: 114 MLPEKDCCYALYDASFETKKSGRVLFVCLFLWAPELPPLKSKMIFTSCKDAIKKKFQANG 173

Query: 151 IKDEVFGTVKEDVSLHGY 168
            +D  +  + E   L GY
Sbjct: 174 PEDLNWACIAE--KLDGY 189


>gi|169165083 PREDICTED: similar to Destrin (actin depolymerizing
           factor) [Homo sapiens]
          Length = 252

 Score = 33.5 bits (75), Expect = 0.33
 Identities = 18/78 (23%), Positives = 38/78 (48%), Gaps = 5/78 (6%)

Query: 94  LLEDKQPCYILFRLDSQNAQGYEWIFIA---WSPDHSHVRQKMLYAATRATLKKEFGGGH 150
           +L +K  CY L+    +  +    +F+    W+P+   ++ KM++ + +  +KK+F    
Sbjct: 167 MLPEKDCCYALYDASFETKKSGRVLFVCLFLWAPELPPLKSKMIFTSCKDAIKKKFQANG 226

Query: 151 IKDEVFGTVKEDVSLHGY 168
            +D  +  + E   L GY
Sbjct: 227 PEDLNWACIAE--KLDGY 242


>gi|218749820 hypothetical protein LOC84221 isoform 1 [Homo sapiens]
          Length = 340

 Score = 30.8 bits (68), Expect = 2.1
 Identities = 30/144 (20%), Positives = 59/144 (40%), Gaps = 7/144 (4%)

Query: 169 KKYLLSQSSPAPLTAAEEELRQIKINEVQTDVGVDTKHQTLQGVAFPISRE----AFQAL 224
           KK   S+SS   L   +   R   +NE+Q+  G +   + +  +AF + R      F  +
Sbjct: 159 KKVCFSESS---LPTGDRTRRSYYLNEIQSFAGAEKDARVVGEIAFQLDRRILAYVFPGV 215

Query: 225 EKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDSARYHFFLYKHSHEGDYL 284
            +L    +  +  +I+  +   +  +    +L++L +R    SAR     Y       + 
Sbjct: 216 TRLYGFTVANIPEKIEQTSTKSLDGSVDERKLRELTQRYLALSARLEKLGYSRDVHPAFS 275

Query: 285 ESIVFIYSMPGYTCSIRERMLYSS 308
           E ++  Y +      +R   L+SS
Sbjct: 276 EFLINTYGILKQRPDLRANPLHSS 299


>gi|23346427 hypothetical protein LOC84221 isoform 2 [Homo sapiens]
          Length = 186

 Score = 30.8 bits (68), Expect = 2.1
 Identities = 30/144 (20%), Positives = 59/144 (40%), Gaps = 7/144 (4%)

Query: 169 KKYLLSQSSPAPLTAAEEELRQIKINEVQTDVGVDTKHQTLQGVAFPISRE----AFQAL 224
           KK   S+SS   L   +   R   +NE+Q+  G +   + +  +AF + R      F  +
Sbjct: 5   KKVCFSESS---LPTGDRTRRSYYLNEIQSFAGAEKDARVVGEIAFQLDRRILAYVFPGV 61

Query: 225 EKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDSARYHFFLYKHSHEGDYL 284
            +L    +  +  +I+  +   +  +    +L++L +R    SAR     Y       + 
Sbjct: 62  TRLYGFTVANIPEKIEQTSTKSLDGSVDERKLRELTQRYLALSARLEKLGYSRDVHPAFS 121

Query: 285 ESIVFIYSMPGYTCSIRERMLYSS 308
           E ++  Y +      +R   L+SS
Sbjct: 122 EFLINTYGILKQRPDLRANPLHSS 145


>gi|22749337 THAP domain containing 8 [Homo sapiens]
          Length = 274

 Score = 29.6 bits (65), Expect = 4.8
 Identities = 22/55 (40%), Positives = 26/55 (47%), Gaps = 9/55 (16%)

Query: 13  LGPPAGAAGCTQRRSRELAAAAMSHQTGIQASEDV------KEIFARARNGKYRL 61
           LGP  GA    QRR R L      HQ  +QA E +      + + ARAR G  RL
Sbjct: 173 LGPVLGAL---QRRVRRLQRCQERHQAQLQALERLAQQLHGESLLARARRGLQRL 224


>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
          Length = 1173

 Score = 29.6 bits (65), Expect = 4.8
 Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 5/114 (4%)

Query: 89  SFVLPLLEDKQPCYILFRLDSQNA-QGYEWIFIAWSPDHSHVR-QKMLYAATRATLKKEF 146
           SFVLP     Q    ++R D +NA Q +E +  A+  ++  ++    LYAA+    K++ 
Sbjct: 339 SFVLPFFGLGQ--MYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDI 396

Query: 147 GGGHIKDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDV 200
             GH+K +V     +DV        +L Q+      +A     +I   +VQ DV
Sbjct: 397 AKGHLK-KVTEQYPDDVEAWIELAQILEQTDIQGALSAYGTATRILQEKVQADV 449


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,449,378
Number of Sequences: 37866
Number of extensions: 618731
Number of successful extensions: 1709
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1700
Number of HSP's gapped (non-prelim): 17
length of query: 384
length of database: 18,247,518
effective HSP length: 104
effective length of query: 280
effective length of database: 14,309,454
effective search space: 4006647120
effective search space used: 4006647120
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.