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Search of human proteins with 38708169
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38708169 sorting nexin 25 [Homo sapiens]
(840 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38708169 sorting nexin 25 [Homo sapiens] 1676 0.0
gi|17864088 sorting nexin 13 [Homo sapiens] 203 6e-52
gi|24797145 sorting nexin 14 isoform a [Homo sapiens] 94 7e-19
gi|24797143 sorting nexin 14 isoform b [Homo sapiens] 86 1e-16
gi|157502171 sorting nexin 19 [Homo sapiens] 63 1e-09
gi|156627563 regulator of G-protein signaling 7 [Homo sapiens] 57 9e-08
gi|31742476 regulator of G-protein signalling 6 [Homo sapiens] 52 3e-06
gi|34452688 regulator of G-protein signalling 11 isoform 1 [Homo... 49 2e-05
gi|4506507 regulator of G-protein signalling 11 isoform 2 [Homo ... 49 2e-05
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 45 4e-04
gi|154091028 sorting nexin 29 [Homo sapiens] 43 0.001
gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [H... 42 0.003
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 42 0.003
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 42 0.003
gi|115387108 regulator of G-protein signalling 1 [Homo sapiens] 41 0.004
gi|83716024 kinesin family member 21B [Homo sapiens] 41 0.004
gi|21361304 regulator of G-protein signalling 14 [Homo sapiens] 40 0.007
gi|38569484 kinesin family member 21A [Homo sapiens] 40 0.009
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 40 0.012
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 40 0.012
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 40 0.012
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho... 40 0.012
gi|4507145 sorting nexin 4 [Homo sapiens] 39 0.015
gi|4506505 regulator of G-protein signaling 10 isoform b [Homo s... 39 0.015
gi|52694755 regulator of G-protein signaling 10 isoform a [Homo ... 39 0.015
gi|4506517 regulator of G-protein signaling 2, 24kDa [Homo sapiens] 39 0.020
gi|110347568 centrosomal protein 152kDa [Homo sapiens] 39 0.026
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 39 0.026
gi|4506509 regulator of G-protein signalling 12 isoform 2 [Homo ... 39 0.026
gi|38327601 regulator of G-protein signalling 12 isoform 1 [Homo... 39 0.026
>gi|38708169 sorting nexin 25 [Homo sapiens]
Length = 840
Score = 1676 bits (4340), Expect = 0.0
Identities = 840/840 (100%), Positives = 840/840 (100%)
Query: 1 MDKALKEVFDYSYRDYILSWYGNLSRDEGQLYHLLLEDFWEIARQLHHRLSHVDVVKVVC 60
MDKALKEVFDYSYRDYILSWYGNLSRDEGQLYHLLLEDFWEIARQLHHRLSHVDVVKVVC
Sbjct: 1 MDKALKEVFDYSYRDYILSWYGNLSRDEGQLYHLLLEDFWEIARQLHHRLSHVDVVKVVC 60
Query: 61 NDVVRTLLTHFCDLKAANARHEEQPRPFVLHACLRNSDDEVRFLQTCSRVLVFCLLPSKD 120
NDVVRTLLTHFCDLKAANARHEEQPRPFVLHACLRNSDDEVRFLQTCSRVLVFCLLPSKD
Sbjct: 61 NDVVRTLLTHFCDLKAANARHEEQPRPFVLHACLRNSDDEVRFLQTCSRVLVFCLLPSKD 120
Query: 121 VQSLSLRIMLAEILTTKVLKPVVELLSNPDYINQMLLAQLAYREQMNEHHKRAYTYAPSY 180
VQSLSLRIMLAEILTTKVLKPVVELLSNPDYINQMLLAQLAYREQMNEHHKRAYTYAPSY
Sbjct: 121 VQSLSLRIMLAEILTTKVLKPVVELLSNPDYINQMLLAQLAYREQMNEHHKRAYTYAPSY 180
Query: 181 EDFIKLINSNSDVEFLKQLRYQIVVEIIQATTISSFPQLKRHKGKETAAMKADLLRARNM 240
EDFIKLINSNSDVEFLKQLRYQIVVEIIQATTISSFPQLKRHKGKETAAMKADLLRARNM
Sbjct: 181 EDFIKLINSNSDVEFLKQLRYQIVVEIIQATTISSFPQLKRHKGKETAAMKADLLRARNM 240
Query: 241 KRYINQLTVAKKQCEKRIRILGGPAYDQQEDGALDEGEGPQSQKILQFEDILANTFYREH 300
KRYINQLTVAKKQCEKRIRILGGPAYDQQEDGALDEGEGPQSQKILQFEDILANTFYREH
Sbjct: 241 KRYINQLTVAKKQCEKRIRILGGPAYDQQEDGALDEGEGPQSQKILQFEDILANTFYREH 300
Query: 301 FGMYMERMDKRALISFWESVEHLKNANKNEIPQLVGEIYQNFFVESKEISVEKSLYKEIQ 360
FGMYMERMDKRALISFWESVEHLKNANKNEIPQLVGEIYQNFFVESKEISVEKSLYKEIQ
Sbjct: 301 FGMYMERMDKRALISFWESVEHLKNANKNEIPQLVGEIYQNFFVESKEISVEKSLYKEIQ 360
Query: 361 QCLVGNKGIEVFYKIQEDVYETLKDRYYPSFIVSDLYEKLLIKEEEKHASQMISNKDEMG 420
QCLVGNKGIEVFYKIQEDVYETLKDRYYPSFIVSDLYEKLLIKEEEKHASQMISNKDEMG
Sbjct: 361 QCLVGNKGIEVFYKIQEDVYETLKDRYYPSFIVSDLYEKLLIKEEEKHASQMISNKDEMG 420
Query: 421 PRDEAGEEAVDDGTNQINEQASFAVNKLRELNEKLEYKRQALNSIQNAPKPDKKIVSKLK 480
PRDEAGEEAVDDGTNQINEQASFAVNKLRELNEKLEYKRQALNSIQNAPKPDKKIVSKLK
Sbjct: 421 PRDEAGEEAVDDGTNQINEQASFAVNKLRELNEKLEYKRQALNSIQNAPKPDKKIVSKLK 480
Query: 481 DEIILIEKERTDLQLHMARTDWWCENLGMWKASITSGEVTEENGEQLPCYFVMVSLQEVG 540
DEIILIEKERTDLQLHMARTDWWCENLGMWKASITSGEVTEENGEQLPCYFVMVSLQEVG
Sbjct: 481 DEIILIEKERTDLQLHMARTDWWCENLGMWKASITSGEVTEENGEQLPCYFVMVSLQEVG 540
Query: 541 GVETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDQKFMEKSKNQLNK 600
GVETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDQKFMEKSKNQLNK
Sbjct: 541 GVETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDQKFMEKSKNQLNK 600
Query: 601 FLQNLLSDERLCQSEALYAFLSPSPDYLKVIDVQGKKNSFSLSSFLERLPRDFFSHQEEE 660
FLQNLLSDERLCQSEALYAFLSPSPDYLKVIDVQGKKNSFSLSSFLERLPRDFFSHQEEE
Sbjct: 601 FLQNLLSDERLCQSEALYAFLSPSPDYLKVIDVQGKKNSFSLSSFLERLPRDFFSHQEEE 660
Query: 661 TEEDSDLSDYGDDVDGRKDALAEPCFMLIGEIFELRGMFKWVRRTLIALVQVTFGRTINK 720
TEEDSDLSDYGDDVDGRKDALAEPCFMLIGEIFELRGMFKWVRRTLIALVQVTFGRTINK
Sbjct: 661 TEEDSDLSDYGDDVDGRKDALAEPCFMLIGEIFELRGMFKWVRRTLIALVQVTFGRTINK 720
Query: 721 QIRDTVSWIFSEQMLVYYINIFRDAFWPNGKLAPPTTIRSKEQSQETKQRAQQKLLENIP 780
QIRDTVSWIFSEQMLVYYINIFRDAFWPNGKLAPPTTIRSKEQSQETKQRAQQKLLENIP
Sbjct: 721 QIRDTVSWIFSEQMLVYYINIFRDAFWPNGKLAPPTTIRSKEQSQETKQRAQQKLLENIP 780
Query: 781 DMLQSLVGQQNARHGIIKIFNALQETRANKHLLYALMELLLIELCPELRVHLDQLKAGQV 840
DMLQSLVGQQNARHGIIKIFNALQETRANKHLLYALMELLLIELCPELRVHLDQLKAGQV
Sbjct: 781 DMLQSLVGQQNARHGIIKIFNALQETRANKHLLYALMELLLIELCPELRVHLDQLKAGQV 840
>gi|17864088 sorting nexin 13 [Homo sapiens]
Length = 957
Score = 203 bits (516), Expect = 6e-52
Identities = 229/936 (24%), Positives = 378/936 (40%), Gaps = 218/936 (23%)
Query: 1 MDKALKEVFDYSYRDYILSWYGNLSRDEGQLYHL-------------------------- 34
+D+ L++V +S RDY+ WY LS DE L +
Sbjct: 100 IDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTT 159
Query: 35 -LLEDFW---EIARQLHHRLSHVD-VVKVVCNDVVRTLLTHFCDLKAANARHEEQPRPFV 89
+++DF + R+ +++ D VK D+V T +++ +E R V
Sbjct: 160 RIVDDFGTHLRVFRKAQQKITEKDDQVKGTAEDLVDTFFEVEVEME------KEVCRDLV 213
Query: 90 LHACLRNSDDEVRFLQTCSRVLVFCLLPSKDVQSLSLRIMLAEILTTKVLKPVVELLSNP 149
C D+E FL+ VL++ LLP D Q+ +R + EIL +L P++ LS+P
Sbjct: 214 ---CTSPKDEE-GFLRDLCEVLLYLLLPPGDFQNKIMRYFVREILARGILLPLINQLSDP 269
Query: 150 DYINQMLLAQLAYREQMNEHHKRAYTYAPSYEDFIKLINSNSDVEFLKQLRYQIVVEIIQ 209
DYINQ ++ + +YE F+ +I + ++ L+ +R + E
Sbjct: 270 DYINQYVIWMIRDSNC-------------NYEAFMNIIKLSDNIGELEAVRDKAAEE--- 313
Query: 210 ATTISSFPQLKRHKGKETAAMKADLLRARNMKRYINQLTVAKKQCEKRIRILGGPAYDQQ 269
L+ + +TA + + K IN L KK C+ RI+ L
Sbjct: 314 ---------LQYLRSLDTAGDDINTI-----KNQINSLLFVKKVCDSRIQRLQSGKEINT 359
Query: 270 EDGALDEGEGPQSQKILQFEDILANTFYREHFGMYMERMDKRALISFWESVE-------- 321
A + G+ + + IL + + F YM++ +A + FW +VE
Sbjct: 360 VKLAANFGK----LCTVPLDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQ 415
Query: 322 -------------HLKNANKNEIPQLVGEIYQNFFVE--SKEISVEKSLYKEIQQCLVGN 366
H N K + IY+ + E S ++V+ L ++ L
Sbjct: 416 QLEVLLSRQRDGKHQTNQTKGLLRAAAVGIYEQYLSEKASPRVTVDDYLVAKLADTLNHE 475
Query: 367 KGI-EVFYKIQEDVYETL--KDRYYPSFIVSDLYEKLLIKEEEKHASQMISNKDEMGPRD 423
E+F IQ VYE + +R+YPSF + LY ++L + + M+ + G D
Sbjct: 476 DPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVRMLAELD------MLKDPSFRGSDD 529
Query: 424 EAGEEAVDDGTNQINEQASFAVNKLRELNEKLEYKRQALNSIQNAPKPDKKIVSKLKDEI 483
GE T IN +L+ + N D
Sbjct: 530 GDGESFNGSPTGSIN---------------------LSLDDLSNVSSDDS---------- 558
Query: 484 ILIEKERTDLQLHMARTDWWCENLGMWKASITSGEVTEENGEQLPCYFVMVSLQEVGGVE 543
+QLH A I+ V ++G+ Y + V + + E
Sbjct: 559 ---------VQLH---------------AYISDTGVCNDHGKTYALYAITVHRRNLNSEE 594
Query: 544 TKNWTVPRRLSEFQNLHRKLSECVPSLKKV-QLPSLSKLPFKSIDQKFMEKSKNQLNKFL 602
W RR S+F + H +++E SL + +LP K F ++D+ F+EK K LN +L
Sbjct: 595 M--WKTYRRYSDFHDFHMRITEQFESLSSILKLPG--KKTFNNMDRDFLEKRKKDLNAYL 650
Query: 603 QNLLSDERLCQSEAL----YAFLSPSP------DYLKVID--VQGKKNSF---------- 640
Q LL+ E + S AL Y FL D+ + +D V +NS
Sbjct: 651 QLLLAPEMMKASPALAHYVYDFLENKAYSKGKGDFARKMDTFVNPLRNSMRNVSNAVKSL 710
Query: 641 -------------SLSSFLERLPRD----FFSHQEEETEEDSD------LSDYGDDVDGR 677
++ ERL +D FF + DSD + D+VD
Sbjct: 711 PDSLAEGMTKMSDNMGKMSERLGQDIKQSFFKVPPLIPKTDSDPEHRRVSAQLDDNVDD- 769
Query: 678 KDALAEPCFMLIGEIFELRGMFKWVRRT----LIALVQVTFGRTINKQIRDTVSWIFSEQ 733
+ +L+ E+F+L+ +W+RR L L++ T+G TIN++I D V W+ S +
Sbjct: 770 -NIPLRVMLLLMDEVFDLKERNQWLRRNIKNLLQQLIRATYGDTINRKIVDHVDWMTSPE 828
Query: 734 MLVYYINIFRDAFWPNGKLAPPTTIRSKEQSQETKQRAQQKLLENIPDMLQSLVGQQNAR 793
+ + FRDAFWPNG LA R K T+ + KLL +PD L+ ++G + R
Sbjct: 829 QVADSVKRFRDAFWPNGILAEAVPCRDKSIRMRTRVAGKTKLLAIMPDELKHIIGAETTR 888
Query: 794 HGIIKIFNALQETRANKHLLYALMELLLIELCPELR 829
GI+++F Q + N+ ++Y +E L L P+ +
Sbjct: 889 KGILRVFEMFQHNQLNRRMVYVFLEGFLETLFPQYK 924
>gi|24797145 sorting nexin 14 isoform a [Homo sapiens]
Length = 946
Score = 93.6 bits (231), Expect = 7e-19
Identities = 127/584 (21%), Positives = 245/584 (41%), Gaps = 110/584 (18%)
Query: 323 LKNANKNEIPQLVGEIYQNFFVESK--EISVEKSLYKEIQQCLVGN-------KGIEVFY 373
L N + + + +IY+ + ++ +I + + +EIQ+ G + + +
Sbjct: 381 LSNDEMLSLHEELQKIYKTYCLDESIDKIRFDPFIVEEIQRIAEGPYIDVVKLQTMRCLF 440
Query: 374 KIQEDVYETLKDRYYPSFIVSDLYEKLLIKEEEKHASQMISNKDEMGPRDEAGEEAVDDG 433
+ E V L++ + P F SD Y + L++ E N+ G ++DD
Sbjct: 441 EAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSKLNR---------GSLSLDDF 491
Query: 434 TNQINEQASFAVNKLRELNEKLEYKRQALNSIQNAPKPDKKIVSK----LKDEIILIEKE 489
N SF ++++ K++ ++ +++ A P+ + +++ I+++E
Sbjct: 492 RNTQKRGESFGISRI---GSKIKGVFKS-TTMEGAMLPNYGVAEGEDDFIEEGIVVMED- 546
Query: 490 RTDLQLHMARTDWWCENLGMWKASITSGEVTE-------ENGEQLPCYFVMVSLQE--VG 540
D + T NL WK SI + E E E++P + + V +
Sbjct: 547 --DSPVEAVSTPNTPRNLAAWKISIPYVDFFEDPSSERKEKKERIPVFCIDVERNDRRAV 604
Query: 541 GVETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDQKFMEKSKNQLNK 600
G E ++W+V RR EF L KL+E + QLPS + K+ + F++ + + +
Sbjct: 605 GHEPEHWSVYRRYLEFYVLESKLTEFHGAFPDAQLPSKRIIGPKNYE--FLKSKREEFQE 662
Query: 601 FLQNLLSDERLCQSEALYAFLSPSPDYLKVID--------------VQG---KKNSFSLS 643
+LQ LL L S+ L FLSP+ + +D V G K+ L
Sbjct: 663 YLQKLLQHPELSNSQLLADFLSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQHLE 722
Query: 644 SFL-----------------------------ERLPRDFF---SHQEEETEEDSDLSDYG 671
F+ ++L D F +++ E TE + + +
Sbjct: 723 PFIMNFINSCESPKPKPSRPELTILSPTSENNKKLFNDLFKNNANRAENTERKQNQNYFM 782
Query: 672 D--DVDGRKDALAEPCFMLIGE-IFELRGMFKWVRRTLIALVQVTFGRTI----NKQIRD 724
+ V+G D L M +G +F++ W+ L+ ++ F T+ + ++
Sbjct: 783 EVMTVEGVYDYL-----MYVGRVVFQVP---DWLHHLLMG-TRILFKNTLEMYTDYYLQC 833
Query: 725 TVSWIFSEQMLVYYINIFRDAFWPNGKLAPPTTIRSKEQSQETKQRAQQKLLENIPDMLQ 784
+ +F E LV I + RDA + T RS + Q+ ++ ++++ IPD+L
Sbjct: 834 KLEQLFQEHRLVSLITLLRDAIF-----CENTEPRSLQDKQKGAKQTFEEMMNYIPDLLV 888
Query: 785 SLVGQQNARHGIIKIFNALQETRANKHLLYALMELLLIELCPEL 828
+G++ I +F+ LQ+ NK L Y L+++++ EL PEL
Sbjct: 889 KCIGEETKYESIRLLFDGLQQPVLNKQLTYVLLDIVIQELFPEL 932
Score = 63.5 bits (153), Expect = 8e-10
Identities = 41/168 (24%), Positives = 83/168 (49%), Gaps = 14/168 (8%)
Query: 1 MDKALKEVFDYSYRDYILSWYGNLSRDEGQLYHLLLEDFWEIARQLHHRLSHVDVVKVVC 60
+D +L EV + +++ WY +++ DE + L + + A L R+ VD+ ++
Sbjct: 133 VDASLSEVLELVLENFVYPWYRDVTDDESFVDELRITLRF-FASVLIRRIHKVDIPSIIT 191
Query: 61 NDVVRTLLTHFCDLKAANARHEEQPRPFV-----------LHACLRNSDDEVRFLQTCSR 109
+++ + H + AR + + F+ LH LR+ DE+ +L+ +
Sbjct: 192 KKLLKAAMKHIEVI--VKARQKVKNTEFLQQAALEEYGPELHVALRSRRDELHYLRKLTE 249
Query: 110 VLVFCLLPSKDVQSLSLRIMLAEILTTKVLKPVVELLSNPDYINQMLL 157
+L +LP K SL +++ EIL+ V P ++ L++PD +N +L+
Sbjct: 250 LLFPYILPPKATDCRSLTLLIREILSGSVFLPSLDFLADPDTVNHLLI 297
>gi|24797143 sorting nexin 14 isoform b [Homo sapiens]
Length = 893
Score = 85.9 bits (211), Expect = 1e-16
Identities = 124/580 (21%), Positives = 235/580 (40%), Gaps = 111/580 (19%)
Query: 323 LKNANKNEIPQLVGEIYQNFFVESK--EISVEKSLYKEIQQCLVGN-------KGIEVFY 373
L N + + + +IY+ + ++ +I + + +EIQ+ G + + +
Sbjct: 337 LSNDEMLSLHEELQKIYKTYCLDESIDKIRFDPFIVEEIQRIAEGPYIDVVKLQTMRCLF 396
Query: 374 KIQEDVYETLKDRYYPSFIVSDLYEKLLIKEEEKHASQMISNKDEMGPRDEAGEEAVDDG 433
+ E V L++ + P F SD Y + L++ E N++ + G +
Sbjct: 397 EAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSKLNRNTQKRGESFGISRIG-- 454
Query: 434 TNQINEQASFAVNKLRELNEKLEYKRQALNSIQNAPKPDKKIVSKLKDEIILIEKERTDL 493
+K++ + + + L + A D I ++ I+++E D
Sbjct: 455 ------------SKIKGVFKSTTMEGAMLPNYGVAEGEDDFI----EEGIVVMED---DS 495
Query: 494 QLHMARTDWWCENLGMWKASITSGEVTE-------ENGEQLPCYFVMVSLQE--VGGVET 544
+ T NL WK SI + E E E++P + + V + G E
Sbjct: 496 PVEAVSTPNTPRNLAAWKISIPYVDFFEDPSSERKEKKERIPVFCIDVERNDRRAVGHEP 555
Query: 545 KNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDQKFMEKSKNQLNKFLQN 604
++W+V RR EF L KL+E + QLPS + K+ + F++ + + ++LQ
Sbjct: 556 EHWSVYRRYLEFYVLESKLTEFHGAFPDAQLPSKRIIGPKNYE--FLKSKREEFQEYLQK 613
Query: 605 LLSDERLCQSEALYAFLSPSPDYLKVID--------------VQGK---KNSFSLSSFL- 646
LL L S+ L FLSP+ + +D V GK + L F+
Sbjct: 614 LLQHPELSNSQLLADFLSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQHLEPFIM 673
Query: 647 ----------------------------ERLPRDFF---SHQEEETEEDSDLSDYGD--D 673
++L D F +++ E TE + + + +
Sbjct: 674 NFINSCESPKPKPSRPELTILSPTSENNKKLFNDLFKNNANRAENTERKQNQNYFMEVMT 733
Query: 674 VDGRKDALAEPCFMLIGEI-FELRGMFKWVRRTLIALVQVTFGRTINKQ----IRDTVSW 728
V+G D L M +G + F++ W+ L+ ++ F T+ ++ +
Sbjct: 734 VEGVYDYL-----MYVGRVVFQVPD---WLHHLLMG-TRILFKNTLEMYTDYYLQCKLEQ 784
Query: 729 IFSEQMLVYYINIFRDAFWPNGKLAPPTTIRSKEQSQETKQRAQQKLLENIPDMLQSLVG 788
+F E LV I + RDA + T RS + Q+ ++ ++++ IPD+L +G
Sbjct: 785 LFQEHRLVSLITLLRDAIFCEN-----TEPRSLQDKQKGAKQTFEEMMNYIPDLLVKCIG 839
Query: 789 QQNARHGIIKIFNALQETRANKHLLYALMELLLIELCPEL 828
++ I +F+ LQ+ NK L Y L+++++ EL PEL
Sbjct: 840 EETKYESIRLLFDGLQQPVLNKQLTYVLLDIVIQELFPEL 879
Score = 55.1 bits (131), Expect = 3e-07
Identities = 37/140 (26%), Positives = 72/140 (51%), Gaps = 18/140 (12%)
Query: 34 LLLEDF--W---EIARQLHHRLSHVDVVKVVCNDVVRTLLTHFCDLKAANARHEEQPRPF 88
LLLE++ W +I+ ++ LS VD+ ++ +++ + H + AR + + F
Sbjct: 116 LLLENYQPWLDLKISSKVDASLSEVDIPSIITKKLLKAAMKHIEVI--VKARQKVKNTEF 173
Query: 89 V-----------LHACLRNSDDEVRFLQTCSRVLVFCLLPSKDVQSLSLRIMLAEILTTK 137
+ LH LR+ DE+ +L+ + +L +LP K SL +++ EIL+
Sbjct: 174 LQQAALEEYGPELHVALRSRRDELHYLRKLTELLFPYILPPKATDCRSLTLLIREILSGS 233
Query: 138 VLKPVVELLSNPDYINQMLL 157
V P ++ L++PD +N +L+
Sbjct: 234 VFLPSLDFLADPDTVNHLLI 253
>gi|157502171 sorting nexin 19 [Homo sapiens]
Length = 992
Score = 63.2 bits (152), Expect = 1e-09
Identities = 37/148 (25%), Positives = 77/148 (52%), Gaps = 4/148 (2%)
Query: 676 GRKDALAEPCFMLIGEIFELRGMFKWV-RRTLIALVQVTFGRTINKQIRDTVSWIFSEQM 734
G + LA+ L+ + L +KW+ + +++ FG + + + V+ + S Q
Sbjct: 815 GTETELADTALDLL--LLLLTEQWKWLCTENMQKFLRLIFGTLVQRWLEVQVANLTSPQR 872
Query: 735 LVYYINIFRDAFWPNGKLAP-PTTIRSKEQSQETKQRAQQKLLENIPDMLQSLVGQQNAR 793
V Y+ + +++ WP G L P +R++EQ +++A Q L+ +PD++ ++G R
Sbjct: 873 WVQYLLLLQESIWPGGVLPKFPRPVRTQEQKLAAEKQALQSLMGVLPDLVVEILGVNKCR 932
Query: 794 HGIIKIFNALQETRANKHLLYALMELLL 821
+ +LQ+ N+HL+Y L +++L
Sbjct: 933 LSWGLVLESLQQPLINRHLIYCLGDIIL 960
Score = 45.8 bits (107), Expect = 2e-04
Identities = 41/176 (23%), Positives = 81/176 (46%), Gaps = 27/176 (15%)
Query: 1 MDKALKEVFDYSYRDYILSWYGNLSRDEGQLYHLLLEDFWEIA-----RQLHHRLSHVDV 55
+++ + RD++LSWY ++S++ E+ E A ++L R+S +D
Sbjct: 98 LEREINRTIQMIIRDFVLSWYRSVSQEPA------FEEEMEAAMKGLVQELRRRMSVMDS 151
Query: 56 VKVVCNDVVRTL----LTHFCDLKAANARHEEQPRPFVL----------HACLRNSDDEV 101
V + V TL L + K A A P L H + + EV
Sbjct: 152 HAVAQS--VLTLCGCHLQSYIQAKEATAGKNGPVEPSHLWEAYCRATAPHPAVHSPSAEV 209
Query: 102 RFLQTCSRVLVFCLLPSKDVQSLSLRIMLAEILTTKVLKPVVELLSNPDYINQMLL 157
+ + +L+ L+P +++ + R ++ E++T V+ P++ LS+PD+I+ +L+
Sbjct: 210 TYTRGVVNLLLQGLVPKPHLETRTGRHVVVELITCNVILPLISRLSDPDWIHLVLV 265
Score = 40.8 bits (94), Expect = 0.005
Identities = 39/130 (30%), Positives = 63/130 (48%), Gaps = 12/130 (9%)
Query: 548 TVPRRLSEFQNLHRKLSECVPSLKK----VQLPS--LSKLPFKSIDQKFMEKSKNQLNKF 601
TV RR EF NL +L E P L+K V+ P LPF ++D +E K+ L F
Sbjct: 578 TVNRRYREFLNLQTRLEE-KPDLRKFIKNVKGPKKLFPDLPFGNMDSDRVEARKSLLESF 636
Query: 602 LQNLLSDERLCQSEALYAFLSPSPD----YLKVIDVQGKKNSFSLSSFLERLPRDF-FSH 656
L+ L + + SE + FL+ + D ++K + + + +S+ ++ L F S
Sbjct: 637 LKQLCAIPEIANSEEVQEFLALNTDARIAFVKKPFMVSRIDKMVVSAIVDTLKTAFPRSE 696
Query: 657 QEEETEEDSD 666
+ TEE S+
Sbjct: 697 PQSPTEELSE 706
>gi|156627563 regulator of G-protein signaling 7 [Homo sapiens]
Length = 487
Score = 56.6 bits (135), Expect = 9e-08
Identities = 39/134 (29%), Positives = 63/134 (47%), Gaps = 7/134 (5%)
Query: 274 LDEGEGPQSQKILQF----EDILANTFYREHFGMYMERMDKRALISFWESVEHLKNANKN 329
L+ + P Q++ ++ ++ L + RE F ++E + FW +VE LK
Sbjct: 316 LEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIK 375
Query: 330 EIPQLVGEIYQNFFVES--KEISVEKSLYKEIQQCLVGNKGIEVFYKIQEDVYETLKDRY 387
E+P V EI+Q F I+++ Y + Q V G F QE +Y+ +K
Sbjct: 376 EVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQ-NVKEPGRYTFEDAQEHIYKLMKSDS 434
Query: 388 YPSFIVSDLYEKLL 401
YP FI S Y++LL
Sbjct: 435 YPRFIRSSAYQELL 448
>gi|31742476 regulator of G-protein signalling 6 [Homo sapiens]
Length = 472
Score = 51.6 bits (122), Expect = 3e-06
Identities = 35/139 (25%), Positives = 67/139 (48%), Gaps = 7/139 (5%)
Query: 274 LDEGEGPQSQKI----LQFEDILANTFYREHFGMYMERMDKRALISFWESVEHLKNANKN 329
++ + P Q++ F++IL + R+ F ++E + FW +V+ LK
Sbjct: 319 IEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQ 378
Query: 330 EIPQLVGEIYQNFFVES--KEISVEKSLYKEIQQCLVGNKGIEVFYKIQEDVYETLKDRY 387
++ + V EI+Q F I+++ Y EI V + G F QE +Y+ +K
Sbjct: 379 DVAKRVEEIWQEFLAPGAPSAINLDSHSY-EITSQNVKDGGRYTFEDAQEHIYKLMKSDS 437
Query: 388 YPSFIVSDLYEKLLIKEEE 406
Y F+ S+ Y+ LL+ +++
Sbjct: 438 YARFLRSNAYQDLLLAKKK 456
>gi|34452688 regulator of G-protein signalling 11 isoform 1 [Homo
sapiens]
Length = 467
Score = 48.9 bits (115), Expect = 2e-05
Identities = 31/118 (26%), Positives = 58/118 (49%), Gaps = 7/118 (5%)
Query: 288 FEDILANTFYREHFGMYMERMDKRALISFWESVEHLKNANKNEIPQLVGEIYQNFFVESK 347
F ++L + R HF ++ + +SFWE+ E L+ + ++P LV +Y+ F
Sbjct: 304 FRELLEDPVGRAHFMDFLGKEFSGENLSFWEACEELRYGAQAQVPTLVDAVYEQFLAPGA 363
Query: 348 E--ISVEKSLYKEIQQCLVGNKGIE--VFYKIQEDVYETLKDRYYPSFIVSDLYEKLL 401
++++ + ++Q L G + V Q +Y +K YP F+ SD+Y+ LL
Sbjct: 364 AHWVNIDS---RTMEQTLEGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSDMYKALL 418
>gi|4506507 regulator of G-protein signalling 11 isoform 2 [Homo
sapiens]
Length = 446
Score = 48.9 bits (115), Expect = 2e-05
Identities = 31/118 (26%), Positives = 58/118 (49%), Gaps = 7/118 (5%)
Query: 288 FEDILANTFYREHFGMYMERMDKRALISFWESVEHLKNANKNEIPQLVGEIYQNFFVESK 347
F ++L + R HF ++ + +SFWE+ E L+ + ++P LV +Y+ F
Sbjct: 283 FRELLEDPVGRAHFMDFLGKEFSGENLSFWEACEELRYGAQAQVPTLVDAVYEQFLAPGA 342
Query: 348 E--ISVEKSLYKEIQQCLVGNKGIE--VFYKIQEDVYETLKDRYYPSFIVSDLYEKLL 401
++++ + ++Q L G + V Q +Y +K YP F+ SD+Y+ LL
Sbjct: 343 AHWVNIDS---RTMEQTLEGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSDMYKALL 397
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 44.7 bits (104), Expect = 4e-04
Identities = 96/463 (20%), Positives = 192/463 (41%), Gaps = 61/463 (13%)
Query: 150 DYINQMLLAQLAYREQMNE----HHKRAYTYAPSYEDFIKLINSNS----DVEFLKQLRY 201
D+ ++M + Q A+++++ E H + Y E+ L+ + + K
Sbjct: 231 DHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEM 290
Query: 202 QIVVEIIQATTISSFPQLKRHKGKETAAMKADLLRARN----MKRYINQLTVAKKQCEKR 257
Q ++++Q + S ++++ + K K L A N ++R QL V K+Q +
Sbjct: 291 QKTIQVLQIEKVESTKKMEQLEDKIKDINKK-LSSAENDRDILRREQEQLNVEKRQIMEE 349
Query: 258 IRILGGPAYDQQEDGALDEGEGPQSQKILQFEDILANTFYREHFGMYMERMDKRALISFW 317
L + E L QS + + E ILA + E + AL
Sbjct: 350 CENL------KLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQ-----ALSDAE 398
Query: 318 ESVEHLKNANK-NEIPQLVGEIYQNFFVESKEISVEKSLYKEIQQCLVGNKGIEVFYKIQ 376
+ L + N+ N + + ++ V KE S+ +E+Q L+ K+
Sbjct: 399 NEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLL---------KLN 449
Query: 377 EDVYETLKDRYYPSFIV-SDLYE-KLLIKEEEKHASQMISNKD----EMGPRDEAGEEAV 430
+ YE +K + S+L++ +L ++ +E+ +Q IS K+ E+ D +EA
Sbjct: 450 NE-YEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEAT 508
Query: 431 DDGT---NQINEQASFAVNKLRELNEKLEYKRQALNSIQNAPKPDKKIVSKLKDEIILIE 487
+Q+++Q + + + +L + L +++ ++ +++ K + K+++I E
Sbjct: 509 KHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSE 568
Query: 488 KERTDLQLHMARTDWWCENL------------GMWKASITSGEVTEENGEQLPCYF--VM 533
DL L + + ENL + K ++ E +N E+L +M
Sbjct: 569 VALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELM 628
Query: 534 VSLQEVGGVETKNWTVPRRLSEFQNLHRKLSECV---PSLKKV 573
SL + K+ + R +E +NL + LSE +LKKV
Sbjct: 629 QSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKV 671
>gi|154091028 sorting nexin 29 [Homo sapiens]
Length = 428
Score = 42.7 bits (99), Expect = 0.001
Identities = 19/66 (28%), Positives = 37/66 (56%), Gaps = 2/66 (3%)
Query: 542 VETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDQKFMEKSKNQLNKF 601
++ W + RR +EF++LH KL P ++ P + K D KF+E+ + QL +
Sbjct: 299 IKDDEWNIYRRYTEFRSLHHKLQNKYPQVRAYNFPPKKAIGNK--DAKFVEERRKQLQNY 356
Query: 602 LQNLLS 607
L+++++
Sbjct: 357 LRSVMN 362
>gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [Homo
sapiens]
Length = 464
Score = 41.6 bits (96), Expect = 0.003
Identities = 36/115 (31%), Positives = 54/115 (46%), Gaps = 20/115 (17%)
Query: 513 SITSGEVTEENGEQLPCYFVMVSLQEVGGVETKNWTVPRRLSEFQNLHRKLSECVPSLKK 572
SI S + E ++ Y V+VS V W V RR +EF L+ L K
Sbjct: 17 SIPSSDEHREKKKRFTVYKVLVS------VGRSEWFVFRRYAEFDKLYNTL--------K 62
Query: 573 VQLPSLS-KLPFKSI-----DQKFMEKSKNQLNKFLQNLLSDERLCQSEALYAFL 621
Q P+++ K+P K I D F+++ + LN+F+QNL+ L + AFL
Sbjct: 63 KQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFL 117
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 41.6 bits (96), Expect = 0.003
Identities = 36/115 (31%), Positives = 54/115 (46%), Gaps = 20/115 (17%)
Query: 513 SITSGEVTEENGEQLPCYFVMVSLQEVGGVETKNWTVPRRLSEFQNLHRKLSECVPSLKK 572
SI S + E ++ Y V+VS V W V RR +EF L+ L K
Sbjct: 17 SIPSSDEHREKKKRFTVYKVLVS------VGRSEWFVFRRYAEFDKLYNTL--------K 62
Query: 573 VQLPSLS-KLPFKSI-----DQKFMEKSKNQLNKFLQNLLSDERLCQSEALYAFL 621
Q P+++ K+P K I D F+++ + LN+F+QNL+ L + AFL
Sbjct: 63 KQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFL 117
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 41.6 bits (96), Expect = 0.003
Identities = 36/115 (31%), Positives = 54/115 (46%), Gaps = 20/115 (17%)
Query: 513 SITSGEVTEENGEQLPCYFVMVSLQEVGGVETKNWTVPRRLSEFQNLHRKLSECVPSLKK 572
SI S + E ++ Y V+VS V W V RR +EF L+ L K
Sbjct: 17 SIPSSDEHREKKKRFTVYKVLVS------VGRSEWFVFRRYAEFDKLYNTL--------K 62
Query: 573 VQLPSLS-KLPFKSI-----DQKFMEKSKNQLNKFLQNLLSDERLCQSEALYAFL 621
Q P+++ K+P K I D F+++ + LN+F+QNL+ L + AFL
Sbjct: 63 KQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFL 117
>gi|115387108 regulator of G-protein signalling 1 [Homo sapiens]
Length = 209
Score = 41.2 bits (95), Expect = 0.004
Identities = 32/119 (26%), Positives = 56/119 (47%), Gaps = 11/119 (9%)
Query: 289 EDILANTFYREHFGMYMERMDKRALISFWESVEHLKNANKNEIPQLVGEIYQNFFVE--S 346
E +LAN + FG +++ I FW + E K + +P EIY+ F +
Sbjct: 87 EKLLANQTGQNVFGSFLKSEFSEENIEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAA 146
Query: 347 KEISVE----KSLYKEIQQCLVGNKGIEVFYKIQEDVYETLKDRYYPSFIVSDLYEKLL 401
K+I+++ +S K+I+ F + Q+ +Y ++ YP F+ SD+Y LL
Sbjct: 147 KQINIDFRTRESTAKKIKA-----PTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLL 200
>gi|83716024 kinesin family member 21B [Homo sapiens]
Length = 1624
Score = 41.2 bits (95), Expect = 0.004
Identities = 37/210 (17%), Positives = 96/210 (45%), Gaps = 27/210 (12%)
Query: 405 EEKHASQMISNKDEMGPRDEAG-----------EEAVDDGTNQINEQASFAVNKLRELNE 453
+E A + +DE G +E G E VD ++ ++ +F + L +L
Sbjct: 583 DENEAEEEEEERDESGCEEEEGREDEDEDSGSEESLVDSDSDPEEKEVNFQAD-LADLTC 641
Query: 454 KLEYKRQALNSIQNAPKPDKKIVSKLKDEIILIEKERTDLQLHMARTDWWCENLGMWKAS 513
++E K++ ++ ++N+ + + + + ++++IL++ + D QL R +NL +
Sbjct: 642 EIEIKQKLIDELENSQRRLQTLKHQYEEKLILLQNKIRDTQLERDRV---LQNLSTMEC- 697
Query: 514 ITSGEVTEENGEQLPCYF------VMVSLQEVGGVETKNWTVPRRLSEFQNLHRKLSECV 567
TEE ++ + + LQ++ + ++ + + S ++ +KL V
Sbjct: 698 -----YTEEKANKIKADYEKRLREMNRDLQKLQAAQKEHARLLKNQSRYERELKKLQAEV 752
Query: 568 PSLKKVQLPSLSKLPFKSIDQKFMEKSKNQ 597
+KK ++ + ++ + ++ +E +N+
Sbjct: 753 AEMKKAKVALMKQMREEQQRRRLVETKRNR 782
>gi|21361304 regulator of G-protein signalling 14 [Homo sapiens]
Length = 566
Score = 40.4 bits (93), Expect = 0.007
Identities = 29/132 (21%), Positives = 56/132 (42%), Gaps = 3/132 (2%)
Query: 278 EGPQSQKILQFEDILANTFYREHFGMYMERMDKRALISFWESVEHLKNANKNEIPQLVGE 337
E P + L FE +L + +F ++++ ++FW++ E + ++ QL E
Sbjct: 58 EQPVASWALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTQQLAQE 117
Query: 338 ---IYQNFFVESKEISVEKSLYKEIQQCLVGNKGIEVFYKIQEDVYETLKDRYYPSFIVS 394
IYQ F V + + ++ ++F Q ++ +K Y F+ S
Sbjct: 118 ARNIYQEFLSSQALSPVNIDRQAWLGEEVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKS 177
Query: 395 DLYEKLLIKEEE 406
LY + L+ E E
Sbjct: 178 PLYRECLLAEAE 189
>gi|38569484 kinesin family member 21A [Homo sapiens]
Length = 1661
Score = 40.0 bits (92), Expect = 0.009
Identities = 35/213 (16%), Positives = 103/213 (48%), Gaps = 13/213 (6%)
Query: 404 EEEKHASQMISNKDEMGPRDEAGEEAVDDGTN------QINEQASFAVNKLRELNEKLEY 457
E E SQ +S+ ++ +E E+ +D G + + +E+A++ + L + ++
Sbjct: 585 ELEVEESQEVSDHEDEEEEEEEEEDDIDGGESSDESDSESDEKANYQAD-LANITCEIAI 643
Query: 458 KRQALNSIQNAPKPDKKIVSKLKDEIILIEKERTDLQLHMARTDWWCENLGMWKASITSG 517
K++ ++ ++N+ K + + + ++++++++ + D QL D +NLG ++
Sbjct: 644 KQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLER---DQVLQNLGSVESYSEEK 700
Query: 518 EVTEENGEQLPCYFVMVSLQEVGGVETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPS 577
+ + + LQ + + ++ + + S+++ +KL + V +KK ++
Sbjct: 701 AKKVRSEYEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRL 760
Query: 578 LSKLPFKSIDQKFMEKSKNQLNKFLQNLLSDER 610
+ ++ +Q+ ++++ N+ + L D+R
Sbjct: 761 MKQM---KEEQEKARLTESRRNREIAQLKKDQR 790
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 39.7 bits (91), Expect = 0.012
Identities = 70/340 (20%), Positives = 140/340 (41%), Gaps = 37/340 (10%)
Query: 197 KQLRYQIVVEIIQATTISSFPQLKRHKGKETAAMKADL---LRARNMKRYINQLTVAKKQ 253
KQ ++ +++ Q + S ++ + +GK + K + + YI +++ A Q
Sbjct: 101 KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQ 160
Query: 254 CEKRIRILGGPAYDQQEDGALDEGEGPQSQKILQFEDILANTFYREHFGMYMERMDKRAL 313
EK + Q E+ ++ + S K E+I+ + E + + ++K
Sbjct: 161 VEKYKLDIA-----QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE 215
Query: 314 ISFWESVEHLKNANKNEIPQLVGEIYQNFFVESKEISVEKSLYKEIQQCLVGNKGIEVFY 373
+ EH +N N + + Q F +E +E EK KE+Q I+
Sbjct: 216 DHVNRNREHNENLNAE-----MQNLKQKFILEQQER--EKLQQKELQ--------IDSLL 260
Query: 374 KIQEDVYETLKDRYYPSFIVSDLYEKLLIKEEEKHASQMISNKDEMGPRDEAGEEAVDDG 433
+ ++++ +L + SF + EK L +EE K Q + D++ ++E E V
Sbjct: 261 QQEKELSSSLHQKLC-SFQEEMVKEKNLFEEELK---QTLDELDKLQQKEEQAERLV--- 313
Query: 434 TNQINEQASFAVNKLRELNEKLEYKRQALNSIQNAPKPDKKIVSKLKDEII-LIEKERTD 492
Q+ E+A +L+ L EKL+ K L A ++ + D ++ +E
Sbjct: 314 -KQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQ 372
Query: 493 LQLHMART-----DWWCENLGMWKASITSGEVTEENGEQL 527
+ + A T D EN + + + +G+ E+ Q+
Sbjct: 373 FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 412
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 39.7 bits (91), Expect = 0.012
Identities = 70/340 (20%), Positives = 140/340 (41%), Gaps = 37/340 (10%)
Query: 197 KQLRYQIVVEIIQATTISSFPQLKRHKGKETAAMKADL---LRARNMKRYINQLTVAKKQ 253
KQ ++ +++ Q + S ++ + +GK + K + + YI +++ A Q
Sbjct: 188 KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQ 247
Query: 254 CEKRIRILGGPAYDQQEDGALDEGEGPQSQKILQFEDILANTFYREHFGMYMERMDKRAL 313
EK + Q E+ ++ + S K E+I+ + E + + ++K
Sbjct: 248 VEKYKLDIA-----QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE 302
Query: 314 ISFWESVEHLKNANKNEIPQLVGEIYQNFFVESKEISVEKSLYKEIQQCLVGNKGIEVFY 373
+ EH +N N + + Q F +E +E EK KE+Q I+
Sbjct: 303 DHVNRNREHNENLNAE-----MQNLKQKFILEQQER--EKLQQKELQ--------IDSLL 347
Query: 374 KIQEDVYETLKDRYYPSFIVSDLYEKLLIKEEEKHASQMISNKDEMGPRDEAGEEAVDDG 433
+ ++++ +L + SF + EK L +EE K Q + D++ ++E E V
Sbjct: 348 QQEKELSSSLHQKLC-SFQEEMVKEKNLFEEELK---QTLDELDKLQQKEEQAERLV--- 400
Query: 434 TNQINEQASFAVNKLRELNEKLEYKRQALNSIQNAPKPDKKIVSKLKDEII-LIEKERTD 492
Q+ E+A +L+ L EKL+ K L A ++ + D ++ +E
Sbjct: 401 -KQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQ 459
Query: 493 LQLHMART-----DWWCENLGMWKASITSGEVTEENGEQL 527
+ + A T D EN + + + +G+ E+ Q+
Sbjct: 460 FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 499
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 39.7 bits (91), Expect = 0.012
Identities = 70/340 (20%), Positives = 140/340 (41%), Gaps = 37/340 (10%)
Query: 197 KQLRYQIVVEIIQATTISSFPQLKRHKGKETAAMKADL---LRARNMKRYINQLTVAKKQ 253
KQ ++ +++ Q + S ++ + +GK + K + + YI +++ A Q
Sbjct: 172 KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQ 231
Query: 254 CEKRIRILGGPAYDQQEDGALDEGEGPQSQKILQFEDILANTFYREHFGMYMERMDKRAL 313
EK + Q E+ ++ + S K E+I+ + E + + ++K
Sbjct: 232 VEKYKLDIA-----QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE 286
Query: 314 ISFWESVEHLKNANKNEIPQLVGEIYQNFFVESKEISVEKSLYKEIQQCLVGNKGIEVFY 373
+ EH +N N + + Q F +E +E EK KE+Q I+
Sbjct: 287 DHVNRNREHNENLNAE-----MQNLKQKFILEQQER--EKLQQKELQ--------IDSLL 331
Query: 374 KIQEDVYETLKDRYYPSFIVSDLYEKLLIKEEEKHASQMISNKDEMGPRDEAGEEAVDDG 433
+ ++++ +L + SF + EK L +EE K Q + D++ ++E E V
Sbjct: 332 QQEKELSSSLHQKLC-SFQEEMVKEKNLFEEELK---QTLDELDKLQQKEEQAERLV--- 384
Query: 434 TNQINEQASFAVNKLRELNEKLEYKRQALNSIQNAPKPDKKIVSKLKDEII-LIEKERTD 492
Q+ E+A +L+ L EKL+ K L A ++ + D ++ +E
Sbjct: 385 -KQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQ 443
Query: 493 LQLHMART-----DWWCENLGMWKASITSGEVTEENGEQL 527
+ + A T D EN + + + +G+ E+ Q+
Sbjct: 444 FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 483
>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
sapiens]
Length = 724
Score = 39.7 bits (91), Expect = 0.012
Identities = 70/340 (20%), Positives = 140/340 (41%), Gaps = 37/340 (10%)
Query: 197 KQLRYQIVVEIIQATTISSFPQLKRHKGKETAAMKADL---LRARNMKRYINQLTVAKKQ 253
KQ ++ +++ Q + S ++ + +GK + K + + YI +++ A Q
Sbjct: 187 KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQ 246
Query: 254 CEKRIRILGGPAYDQQEDGALDEGEGPQSQKILQFEDILANTFYREHFGMYMERMDKRAL 313
EK + Q E+ ++ + S K E+I+ + E + + ++K
Sbjct: 247 VEKYKLDIA-----QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE 301
Query: 314 ISFWESVEHLKNANKNEIPQLVGEIYQNFFVESKEISVEKSLYKEIQQCLVGNKGIEVFY 373
+ EH +N N + + Q F +E +E EK KE+Q I+
Sbjct: 302 DHVNRNREHNENLNAE-----MQNLKQKFILEQQER--EKLQQKELQ--------IDSLL 346
Query: 374 KIQEDVYETLKDRYYPSFIVSDLYEKLLIKEEEKHASQMISNKDEMGPRDEAGEEAVDDG 433
+ ++++ +L + SF + EK L +EE K Q + D++ ++E E V
Sbjct: 347 QQEKELSSSLHQKLC-SFQEEMVKEKNLFEEELK---QTLDELDKLQQKEEQAERLV--- 399
Query: 434 TNQINEQASFAVNKLRELNEKLEYKRQALNSIQNAPKPDKKIVSKLKDEII-LIEKERTD 492
Q+ E+A +L+ L EKL+ K L A ++ + D ++ +E
Sbjct: 400 -KQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQ 458
Query: 493 LQLHMART-----DWWCENLGMWKASITSGEVTEENGEQL 527
+ + A T D EN + + + +G+ E+ Q+
Sbjct: 459 FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 498
>gi|4507145 sorting nexin 4 [Homo sapiens]
Length = 450
Score = 39.3 bits (90), Expect = 0.015
Identities = 41/187 (21%), Positives = 76/187 (40%), Gaps = 13/187 (6%)
Query: 497 MARTDWWCENL--GMWKASITSGEVTEENGEQLPCYFVMV-SLQEVGGVETKNWTVPRRL 553
M ++W + + + +A +G E Y + S++ G ++ RR
Sbjct: 48 MTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYLIETRSVEHTDGQSVLTDSLWRRY 107
Query: 554 SEFQNLHRKLSECVPSLKKVQLPSLS------KLPFKSIDQKFMEKSKNQLNKFLQNLLS 607
SEF+ L L P + LP KL ++D F+E+ + L FL + S
Sbjct: 108 SEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRIAS 167
Query: 608 DERLCQSEALYAFLSPSPDYLKVIDVQGKKNSFSLSSFLERLPRDFFSHQEEETEEDSDL 667
LC+ + Y FL+ ++ + ++ G + S L+ L F + + +DL
Sbjct: 168 HPILCRDKIFYLFLTQEGNWKETVNETGFQ--LKADSRLKALNATF--RVKNPDKRFTDL 223
Query: 668 SDYGDDV 674
Y D++
Sbjct: 224 KHYSDEL 230
>gi|4506505 regulator of G-protein signaling 10 isoform b [Homo
sapiens]
Length = 167
Score = 39.3 bits (90), Expect = 0.015
Identities = 26/120 (21%), Positives = 53/120 (44%), Gaps = 1/120 (0%)
Query: 289 EDILANTFYREHFGMYMERMDKRALISFWESVEHLKNA-NKNEIPQLVGEIYQNFFVESK 347
E++L + + F ++++ + FW + E K +K ++ + EIY F
Sbjct: 29 ENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKA 88
Query: 348 EISVEKSLYKEIQQCLVGNKGIEVFYKIQEDVYETLKDRYYPSFIVSDLYEKLLIKEEEK 407
V + + ++ +F K+Q+ ++ +K Y F+ SDL+ K EEE+
Sbjct: 89 SSQVNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEE 148
>gi|52694755 regulator of G-protein signaling 10 isoform a [Homo
sapiens]
Length = 181
Score = 39.3 bits (90), Expect = 0.015
Identities = 26/120 (21%), Positives = 53/120 (44%), Gaps = 1/120 (0%)
Query: 289 EDILANTFYREHFGMYMERMDKRALISFWESVEHLKNA-NKNEIPQLVGEIYQNFFVESK 347
E++L + + F ++++ + FW + E K +K ++ + EIY F
Sbjct: 43 ENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKA 102
Query: 348 EISVEKSLYKEIQQCLVGNKGIEVFYKIQEDVYETLKDRYYPSFIVSDLYEKLLIKEEEK 407
V + + ++ +F K+Q+ ++ +K Y F+ SDL+ K EEE+
Sbjct: 103 SSQVNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEE 162
>gi|4506517 regulator of G-protein signaling 2, 24kDa [Homo sapiens]
Length = 211
Score = 38.9 bits (89), Expect = 0.020
Identities = 34/133 (25%), Positives = 63/133 (47%), Gaps = 15/133 (11%)
Query: 288 FEDILANTFYREHFGMYMERMDKRALISFWESVEHLKNANK-NEIPQLVGEIYQNFFVES 346
F+++LA+ + F +++ I FW + E K ++ +IY +F +
Sbjct: 84 FDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKE 143
Query: 347 --KEISVE---KSLYKE-IQQCLVGNKGIEVFYKIQEDVYETLKDRYYPSFIVSDLYEKL 400
KEI+++ K+L + IQ+ G F Q+ VY +++ YP F+ S+ Y+ L
Sbjct: 144 APKEINIDFQTKTLIAQNIQEATSG-----CFTTAQKRVYSLMENNSYPRFLESEFYQDL 198
Query: 401 LIKEE---EKHAS 410
K + E HA+
Sbjct: 199 CKKPQITTEPHAT 211
>gi|110347568 centrosomal protein 152kDa [Homo sapiens]
Length = 1654
Score = 38.5 bits (88), Expect = 0.026
Identities = 90/422 (21%), Positives = 182/422 (43%), Gaps = 64/422 (15%)
Query: 402 IKEEEKHASQMISNKDEMGPRDEAGE----EAVDDGTNQINEQA--------SFAVNKLR 449
+KE+E S++ + ++ EA + E ++ T + E S +V ++
Sbjct: 388 LKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVA 447
Query: 450 ELNEKLEYKRQALNSIQNAPKPDKKIVSKLKDEIILIEKER--------TDLQLHMARTD 501
+L +L+ ++A N K ++ +++LKDEI L E ++ +L++ T+
Sbjct: 448 QLQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTE 507
Query: 502 WWCENLGM----WKASITSGEVTEE--NGEQLPCYFVMVSLQEVGGVETKNWTVPRRLSE 555
+ + LG+ WK S + V EE N E F++ EV + N +S+
Sbjct: 508 SYVD-LGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQ 566
Query: 556 FQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDQKFM----EKSKNQL--NKFLQNLLSDE 609
QN L +C KK++ K KSI+ + EK KNQL +++ D+
Sbjct: 567 LQN---DLKDCH---KKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDD 620
Query: 610 RLCQSEALYAFLSPSPDYLKVIDVQGKKNSFSLSSFLERLPRDFFSHQEEETEEDSDLSD 669
L + + + LK + + + + L + + ++ +DF H ++E + + +
Sbjct: 621 ILLLKNEIQVLQQQNQE-LKETEGKLRNTNQDLCNQMRQMVQDF-DHDKQEAVDRCERT- 677
Query: 670 YGDDVDGRKDALAEPCFMLIGEIFELRGMFKWVRRTLIALVQVTFGRTINKQIRDTVSWI 729
Y + K + E +L E + +F+ RT + Q+R + +
Sbjct: 678 YQQHHEAMKTQIRES--LLAKHALEKQQLFEAYERTHL-------------QLRSELDKL 722
Query: 730 FSEQMLVY--YINIFRDAFWPNGKLAPPTTIRSKEQSQETKQRAQQKLLENIPDMLQSLV 787
E V Y+ + R+ N +L T ++ E+ Q+T+++ ++KL++ + QS +
Sbjct: 723 NKEVTAVQECYLEVCREK--DNLEL---TLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKL 777
Query: 788 GQ 789
Q
Sbjct: 778 DQ 779
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 38.5 bits (88), Expect = 0.026
Identities = 66/303 (21%), Positives = 126/303 (41%), Gaps = 46/303 (15%)
Query: 320 VEHLKNANKNEIPQLVGEIYQNFFVESKEISVEKSLYKEIQQCLVGNKGIEVFYKIQEDV 379
VE K+A +N++ L E+ +K +K+L + QQ L +++ED
Sbjct: 968 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD-------LQMEEDK 1020
Query: 380 YETL-KDRYYPSFIVSDLYEKLLIKEEEKHASQMISNKDEMGPRDEAGEEAVDDGTNQIN 438
TL K + V DL L E+EK + E + ++
Sbjct: 1021 VNTLTKAKTKLEQQVDDLEGSL---EQEKKLCMDL----------ERAKRKLEGDLKLAQ 1067
Query: 439 EQASFAVNKLRELNEKLEYKRQALNSIQNAPKPDKKIVSKLKDEIILIEKERTDLQLHMA 498
E N ++LNEKL+ K ++++Q + ++ + +L+ +I ++ +L+ +
Sbjct: 1068 ESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIE 1127
Query: 499 RTDWWCENLGMWKASITSGEVTEENGEQLPCYFVMVSLQEVGGVETKNWTV-PRRLSEFQ 557
E KA +++ E E + L+E GG + + +R +EFQ
Sbjct: 1128 -----AERASRAKAEKQRSDLSRELEE------ISERLEEAGGATSAQIEMNKKREAEFQ 1176
Query: 558 NLHRKLSE-------CVPSLKKVQLPSLSKL-----PFKSIDQKFMEKSKNQLNKFLQNL 605
+ R L E +L+K S+++L + + QK +EK K++L + +L
Sbjct: 1177 KMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQK-LEKEKSELKMEINDL 1235
Query: 606 LSD 608
S+
Sbjct: 1236 ASN 1238
Score = 30.4 bits (67), Expect = 7.1
Identities = 24/102 (23%), Positives = 52/102 (50%), Gaps = 10/102 (9%)
Query: 403 KEEEKHASQMISNKDEMGPRDEAGEEAVDDGTNQINEQASFAVN---KLRELNEKLEYKR 459
KE E+ ++ K+++ + +A +A+ D + ++ + K++E+ E+ E +
Sbjct: 875 KELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEE 934
Query: 460 QALNSIQNAPKPDKKIVSKLKDEIILIEKERTDLQLHMARTD 501
+ NA KK KL+DE ++K+ DL+L +A+ +
Sbjct: 935 EI-----NAELTAKK--RKLEDECSELKKDIDDLELTLAKVE 969
>gi|4506509 regulator of G-protein signalling 12 isoform 2 [Homo
sapiens]
Length = 1376
Score = 38.5 bits (88), Expect = 0.026
Identities = 26/127 (20%), Positives = 54/127 (42%), Gaps = 3/127 (2%)
Query: 286 LQFEDILANTFYREHFGMYMERMDKRALISFWESVE---HLKNANKNEIPQLVGEIYQNF 342
+ FE +L + +F ++ + I FW++ E H+ +K E+ EI+ F
Sbjct: 714 VSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKF 773
Query: 343 FVESKEISVEKSLYKEIQQCLVGNKGIEVFYKIQEDVYETLKDRYYPSFIVSDLYEKLLI 402
V ++ ++ ++F + Q ++ +K Y F+ S LY++ ++
Sbjct: 774 LCSKATTPVNIDSQAQLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECIL 833
Query: 403 KEEEKHA 409
E E A
Sbjct: 834 AEVEGRA 840
>gi|38327601 regulator of G-protein signalling 12 isoform 1 [Homo
sapiens]
Length = 1447
Score = 38.5 bits (88), Expect = 0.026
Identities = 26/127 (20%), Positives = 54/127 (42%), Gaps = 3/127 (2%)
Query: 286 LQFEDILANTFYREHFGMYMERMDKRALISFWESVE---HLKNANKNEIPQLVGEIYQNF 342
+ FE +L + +F ++ + I FW++ E H+ +K E+ EI+ F
Sbjct: 714 VSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKF 773
Query: 343 FVESKEISVEKSLYKEIQQCLVGNKGIEVFYKIQEDVYETLKDRYYPSFIVSDLYEKLLI 402
V ++ ++ ++F + Q ++ +K Y F+ S LY++ ++
Sbjct: 774 LCSKATTPVNIDSQAQLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECIL 833
Query: 403 KEEEKHA 409
E E A
Sbjct: 834 AEVEGRA 840
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,911,369
Number of Sequences: 37866
Number of extensions: 1311193
Number of successful extensions: 4910
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 124
Number of HSP's that attempted gapping in prelim test: 4747
Number of HSP's gapped (non-prelim): 270
length of query: 840
length of database: 18,247,518
effective HSP length: 111
effective length of query: 729
effective length of database: 14,044,392
effective search space: 10238361768
effective search space used: 10238361768
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.