Search of human proteins with 38201638

Search of human proteins with 38201638

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
[Homo sapiens]
         (1075 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [...  2142   0.0  
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [...  2084   0.0  
gi|38201642 homeodomain-interacting protein kinase 1 isoform 3 [...  1345   0.0  
gi|38201644 homeodomain-interacting protein kinase 1 isoform 4 [...  1290   0.0  
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ...  1286   0.0  
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ...  1247   0.0  
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ...   865   0.0  
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ...   857   0.0  
gi|169171014 PREDICTED: similar to homeodomain interacting prote...   508   e-144
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]   333   5e-91
gi|169171552 PREDICTED: similar to homeodomain interacting prote...   293   8e-79
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula...   221   2e-57
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula...   221   2e-57
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula...   221   2e-57
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula...   221   2e-57
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula...   221   2e-57
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat...   218   2e-56
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat...   215   2e-55
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat...   210   7e-54
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula...   205   2e-52
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul...   197   4e-50
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat...   197   4e-50
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula...   192   1e-48
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula...   192   1e-48
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]               166   1e-40
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]                166   1e-40
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]      165   2e-40
gi|10190706 CDC-like kinase 4 [Homo sapiens]                          153   7e-37
gi|47717134 CDC-like kinase 2 [Homo sapiens]                          147   5e-35
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]               145   2e-34

>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [Homo
            sapiens]
          Length = 1075

 Score = 2142 bits (5551), Expect = 0.0
 Identities = 1075/1075 (100%), Positives = 1075/1075 (100%)

Query: 1    MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSH 60
            MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSH
Sbjct: 1    MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSH 60

Query: 61   QVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQK 120
            QVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQK
Sbjct: 61   QVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQK 120

Query: 121  CGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQH 180
            CGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQH
Sbjct: 121  CGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQH 180

Query: 181  EILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSR 240
            EILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSR
Sbjct: 181  EILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSR 240

Query: 241  LSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVA 300
            LSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVA
Sbjct: 241  LSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVA 300

Query: 301  TALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRA 360
            TALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRA
Sbjct: 301  TALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRA 360

Query: 361  PEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGT 420
            PEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGT
Sbjct: 361  PEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGT 420

Query: 421  KTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTD 480
            KTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTD
Sbjct: 421  KTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTD 480

Query: 481  MLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNME 540
            MLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNME
Sbjct: 481  MLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNME 540

Query: 541  ICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATL 600
            ICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATL
Sbjct: 541  ICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATL 600

Query: 601  SLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQ 660
            SLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQ
Sbjct: 601  SLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQ 660

Query: 661  TGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATIT 720
            TGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATIT
Sbjct: 661  TGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATIT 720

Query: 721  PQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMI 780
            PQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMI
Sbjct: 721  PQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMI 780

Query: 781  PEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSS 840
            PEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSS
Sbjct: 781  PEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSS 840

Query: 841  LPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPS 900
            LPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPS
Sbjct: 841  LPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPS 900

Query: 901  PPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSA 960
            PPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSA
Sbjct: 901  PPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSA 960

Query: 961  LRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQ 1020
            LRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQ
Sbjct: 961  LRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQ 1020

Query: 1021 SSGCCITPTGYRAQRGGTSAAQPLNLSQVSAMGYCLLFGPCTVVTFWRTLLLAGC 1075
            SSGCCITPTGYRAQRGGTSAAQPLNLSQVSAMGYCLLFGPCTVVTFWRTLLLAGC
Sbjct: 1021 SSGCCITPTGYRAQRGGTSAAQPLNLSQVSAMGYCLLFGPCTVVTFWRTLLLAGC 1075


>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [Homo
            sapiens]
          Length = 1210

 Score = 2084 bits (5400), Expect = 0.0
 Identities = 1048/1048 (100%), Positives = 1048/1048 (100%)

Query: 1    MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSH 60
            MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSH
Sbjct: 1    MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSH 60

Query: 61   QVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQK 120
            QVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQK
Sbjct: 61   QVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQK 120

Query: 121  CGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQH 180
            CGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQH
Sbjct: 121  CGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQH 180

Query: 181  EILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSR 240
            EILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSR
Sbjct: 181  EILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSR 240

Query: 241  LSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVA 300
            LSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVA
Sbjct: 241  LSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVA 300

Query: 301  TALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRA 360
            TALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRA
Sbjct: 301  TALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRA 360

Query: 361  PEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGT 420
            PEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGT
Sbjct: 361  PEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGT 420

Query: 421  KTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTD 480
            KTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTD
Sbjct: 421  KTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTD 480

Query: 481  MLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNME 540
            MLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNME
Sbjct: 481  MLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNME 540

Query: 541  ICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATL 600
            ICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATL
Sbjct: 541  ICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATL 600

Query: 601  SLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQ 660
            SLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQ
Sbjct: 601  SLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQ 660

Query: 661  TGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATIT 720
            TGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATIT
Sbjct: 661  TGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATIT 720

Query: 721  PQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMI 780
            PQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMI
Sbjct: 721  PQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMI 780

Query: 781  PEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSS 840
            PEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSS
Sbjct: 781  PEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSS 840

Query: 841  LPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPS 900
            LPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPS
Sbjct: 841  LPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPS 900

Query: 901  PPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSA 960
            PPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSA
Sbjct: 901  PPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSA 960

Query: 961  LRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQ 1020
            LRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQ
Sbjct: 961  LRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQ 1020

Query: 1021 SSGCCITPTGYRAQRGGTSAAQPLNLSQ 1048
            SSGCCITPTGYRAQRGGTSAAQPLNLSQ
Sbjct: 1021 SSGCCITPTGYRAQRGGTSAAQPLNLSQ 1048


>gi|38201642 homeodomain-interacting protein kinase 1 isoform 3 [Homo
            sapiens]
          Length = 836

 Score = 1345 bits (3482), Expect = 0.0
 Identities = 674/674 (100%), Positives = 674/674 (100%)

Query: 375  MWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGY 434
            MWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGY
Sbjct: 1    MWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGY 60

Query: 435  PLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDL 494
            PLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDL
Sbjct: 61   PLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDL 120

Query: 495  LKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQ 554
            LKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQ
Sbjct: 121  LKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQ 180

Query: 555  IKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQS 614
            IKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQS
Sbjct: 181  IKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQS 240

Query: 615  ALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPV 674
            ALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPV
Sbjct: 241  ALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPV 300

Query: 675  RMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAG 734
            RMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAG
Sbjct: 301  RMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAG 360

Query: 735  RPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWR 794
            RPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWR
Sbjct: 361  RPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWR 420

Query: 795  NAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSS 854
            NAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSS
Sbjct: 421  NAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSS 480

Query: 855  KSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDE 914
            KSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDE
Sbjct: 481  KSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDE 540

Query: 915  EEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGR 974
            EEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGR
Sbjct: 541  EEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGR 600

Query: 975  VVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQ 1034
            VVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQ
Sbjct: 601  VVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQ 660

Query: 1035 RGGTSAAQPLNLSQ 1048
            RGGTSAAQPLNLSQ
Sbjct: 661  RGGTSAAQPLNLSQ 674


>gi|38201644 homeodomain-interacting protein kinase 1 isoform 4 [Homo
            sapiens]
          Length = 816

 Score = 1290 bits (3338), Expect = 0.0
 Identities = 649/649 (100%), Positives = 649/649 (100%)

Query: 400  QIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKY 459
            QIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKY
Sbjct: 6    QIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKY 65

Query: 460  IFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVT 519
            IFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVT
Sbjct: 66   IFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVT 125

Query: 520  MTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQL 579
            MTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQL
Sbjct: 126  MTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQL 185

Query: 580  NTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTT 639
            NTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTT
Sbjct: 186  NTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTT 245

Query: 640  QICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVL 699
            QICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVL
Sbjct: 246  QICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVL 305

Query: 700  TQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLP 759
            TQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLP
Sbjct: 306  TQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLP 365

Query: 760  STWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTL 819
            STWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTL
Sbjct: 366  STWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTL 425

Query: 820  ATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSS 879
            ATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSS
Sbjct: 426  ATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSS 485

Query: 880  YNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTV 939
            YNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTV
Sbjct: 486  YNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTV 545

Query: 940  NDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTV 999
            NDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTV
Sbjct: 546  NDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTV 605

Query: 1000 ATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGTSAAQPLNLSQ 1048
            ATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGTSAAQPLNLSQ
Sbjct: 606  ATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGTSAAQPLNLSQ 654


>gi|164420685 homeodomain interacting protein kinase 2 isoform 1 [Homo
            sapiens]
          Length = 1198

 Score = 1286 bits (3329), Expect = 0.0
 Identities = 700/1092 (64%), Positives = 800/1092 (73%), Gaps = 101/1092 (9%)

Query: 1    MASQLQVFSPPSVSSSAFCSAKKLKIEPSG-WDVSGQSSNDKYYTHSKTLPATQGQA--- 56
            MAS +QVFSP ++ SSAFCS KKLKIEPS  WD++G  S+ K Y+ SK +P +Q      
Sbjct: 8    MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV 67

Query: 57   NSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLE 116
            ++S  V N ++P Y+Q ++ P  +  HIVVT+A SS S           L  RS VSLL+
Sbjct: 68   STSLPVPNPSLP-YEQTIVFPG-STGHIVVTSA-SSTSVTGQVLGGPHNLMRRSTVSLLD 124

Query: 117  PYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRT-VVGAAATTTTVTTKSSSSSGEGDY 175
             YQKCGLKRKSEE+++  SVQIIEEHPP++  N +    A ATT+T T+K+S S+ EGDY
Sbjct: 125  TYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDY 184

Query: 176  QLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEV 235
            QLVQHE+LCSMTN+YEVLEFLGRGTFGQV KCWKR T EIVAIKILKNHPSYARQGQIEV
Sbjct: 185  QLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEV 244

Query: 236  SILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPI 295
            SIL+RLS+E+AD+YNFVR+YECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRP+
Sbjct: 245  SILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPV 304

Query: 296  LQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQS 355
            LQQVATALMKLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHVSKAVCSTYLQS
Sbjct: 305  LQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQS 364

Query: 356  RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL 415
            RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL
Sbjct: 365  RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL 424

Query: 416  LSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTD 475
            LSAGTKTTRFFNRD +  YPLWRLKTP++HE ETGIKSKEARKYIFNCLDDMAQVNM+TD
Sbjct: 425  LSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTD 484

Query: 476  LEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSC 535
            LEG+DML EKADRRE+IDLLKKMLTIDADKRITP++TLNH FVTMTHLLDFPHS HVKSC
Sbjct: 485  LEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSC 544

Query: 536  FQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTA 595
            FQNMEICKRRV+MYDTV+Q K+PF THVAP+TSTNLTM+F+NQL TVHNQA       ++
Sbjct: 545  FQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQA------PSS 598

Query: 596  AAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVC 655
             +AT+SLAN +VS+LNY S LY  SAA +  VAQ+ + LQ GT QIC + DPFQQ  IVC
Sbjct: 599  TSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVC 658

Query: 656  PPAFQTGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHP 714
            PP FQ GLQA+ +KH+G+ VRM+NAVPIV QAP AQPLQIQ G+L Q             
Sbjct: 659  PPGFQ-GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ------------- 704

Query: 715  QVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSV 774
                                            QAWP GTQQILLP  WQQL GVA H SV
Sbjct: 705  --------------------------------QAWPSGTQQILLPPAWQQLTGVATHTSV 732

Query: 775  QPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVR 834
            Q   +IPE M   QQLADWRN H+HG+ Y+ IMQQP+LLT HVTL  AQPLNVGVAHV+R
Sbjct: 733  QHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMR 792

Query: 835  QQQSSSLPSKKNKQ-SAPVSSKSSLDVLPSQVYS-----------------LVGSSPLRT 876
            QQ +S+  S+K+KQ  + V + S+ +V  SQ  S                 +V SSP  +
Sbjct: 793  QQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACS 852

Query: 877  TS------SYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPR 930
            TS         S    + Q Q I+IPDTPSP VSVITI SDTDEEE+ K+ P+S+  K R
Sbjct: 853  TSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQR 912

Query: 931  SNVISYVTVNDSPDSDSSL-SSPYSTDTLSALRGNSGSVLEGPGRVVADGTGT-RTIIVP 988
             NVIS VTV+DSP SDSS  +SPYS    +    N+ +  +  G +    TG  RTIIVP
Sbjct: 913  KNVISCVTVHDSPYSDSSSNTSPYSVQQRAG--HNNANAFDTKGSLENHCTGNPRTIIVP 970

Query: 989  PLKTQLGDCTV----------ATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGT 1038
            PLKTQ  +  V          +  +S   S  +  V S SG SSG       YR QR G 
Sbjct: 971  PLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGP 1030

Query: 1039 --SAAQPLNLSQ 1048
                 QPLNLSQ
Sbjct: 1031 HFQQQQPLNLSQ 1042


>gi|164420691 homeodomain interacting protein kinase 2 isoform 2 [Homo
            sapiens]
          Length = 1171

 Score = 1247 bits (3226), Expect = 0.0
 Identities = 685/1092 (62%), Positives = 779/1092 (71%), Gaps = 128/1092 (11%)

Query: 1    MASQLQVFSPPSVSSSAFCSAKKLKIEPSG-WDVSGQSSNDKYYTHSKTLPATQGQA--- 56
            MAS +QVFSP ++ SSAFCS KKLKIEPS  WD++G  S+ K Y+ SK +P +Q      
Sbjct: 8    MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV 67

Query: 57   NSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLE 116
            ++S  V N ++P Y+Q ++ P  +  HIVVT+A SS S           L  RS VSLL+
Sbjct: 68   STSLPVPNPSLP-YEQTIVFPG-STGHIVVTSA-SSTSVTGQVLGGPHNLMRRSTVSLLD 124

Query: 117  PYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRT-VVGAAATTTTVTTKSSSSSGEGDY 175
             YQKCGLKRKSEE+++  SVQIIEEHPP++  N +    A ATT+T T+K+S S+ EGDY
Sbjct: 125  TYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDY 184

Query: 176  QLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEV 235
            QLVQHE+LCSMTN+YEVLEFLGRGTFGQV KCWKR T EIVAIKILKNHPSYARQGQIEV
Sbjct: 185  QLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEV 244

Query: 236  SILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPI 295
            SIL+RLS+E+AD+YNFVR+YECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRP+
Sbjct: 245  SILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPV 304

Query: 296  LQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQS 355
            LQQVATALMKLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHVSKAVCSTYLQS
Sbjct: 305  LQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQS 364

Query: 356  RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL 415
            RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL
Sbjct: 365  RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYL 424

Query: 416  LSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTD 475
            LSAGTKTTRFFNRD +  YPLWRLKTP++HE ETGIKSKEARKYIFNCLDDMAQVNM+TD
Sbjct: 425  LSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTD 484

Query: 476  LEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSC 535
            LEG+DML EKADRRE+IDLLKKMLTIDADKRITP++TLNH FVTMTHLLDFPHS HVKSC
Sbjct: 485  LEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSC 544

Query: 536  FQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTA 595
            FQNMEICKRRV+MYDTV+Q K+PF THVAP+TSTNLTM+F+NQL TVHNQ S        
Sbjct: 545  FQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPS-------- 596

Query: 596  AAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVC 655
                                     AA +  VAQ+ + LQ GT QIC + DPFQQ  IVC
Sbjct: 597  -------------------------AASMAAVAQRSMPLQTGTAQICARPDPFQQALIVC 631

Query: 656  PPAFQTGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHP 714
            PP FQ GLQA+ +KH+G+ VRM+NAVPIV QAP AQPLQIQ G+L Q             
Sbjct: 632  PPGFQ-GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ------------- 677

Query: 715  QVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSV 774
                                            QAWP GTQQILLP  WQQL GVA H SV
Sbjct: 678  --------------------------------QAWPSGTQQILLPPAWQQLTGVATHTSV 705

Query: 775  QPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVR 834
            Q   +IPE M   QQLADWRN H+HG+ Y+ IMQQP+LLT HVTL  AQPLNVGVAHV+R
Sbjct: 706  QHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMR 765

Query: 835  QQQSSSLPSKKNKQ-SAPVSSKSSLDVLPSQVYS-----------------LVGSSPLRT 876
            QQ +S+  S+K+KQ  + V + S+ +V  SQ  S                 +V SSP  +
Sbjct: 766  QQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACS 825

Query: 877  TS------SYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPR 930
            TS         S    + Q Q I+IPDTPSP VSVITI SDTDEEE+ K+ P+S+  K R
Sbjct: 826  TSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQR 885

Query: 931  SNVISYVTVNDSPDSDSSL-SSPYSTDTLSALRGNSGSVLEGPGRVVADGTGT-RTIIVP 988
             NVIS VTV+DSP SDSS  +SPYS    +    N+ +  +  G +    TG  RTIIVP
Sbjct: 886  KNVISCVTVHDSPYSDSSSNTSPYSVQQRAG--HNNANAFDTKGSLENHCTGNPRTIIVP 943

Query: 989  PLKTQLGDCTV----------ATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGT 1038
            PLKTQ  +  V          +  +S   S  +  V S SG SSG       YR QR G 
Sbjct: 944  PLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGP 1003

Query: 1039 --SAAQPLNLSQ 1048
                 QPLNLSQ
Sbjct: 1004 HFQQQQPLNLSQ 1015


>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
           [Homo sapiens]
          Length = 1194

 Score =  865 bits (2234), Expect = 0.0
 Identities = 519/1009 (51%), Positives = 633/1009 (62%), Gaps = 133/1009 (13%)

Query: 1   MASQLQVFSPP--SVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTL----PATQG 54
           MASQ+ V+ P      SSAFCS KKLK+EPS   V  + +  + Y + +      P T+G
Sbjct: 1   MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC-VFQERNYPRTYVNGRNFGNSHPPTKG 59

Query: 55  QANSSHQVANFNIP-AYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVS 113
            A  +     FN P  ++  L   A  +++        +  A  +  Q+ Q    R+ + 
Sbjct: 60  SAFQTK--IPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLH 117

Query: 114 LLEPYQKCGLKRKSEEVDSNGS-VQIIEEHPPLMLQNRTVVGAAATTTTVTT--KSSSSS 170
            LE  Q+CGLKRKSEE+D++ S +QI++E   L    +T +G   T  T TT  K + ++
Sbjct: 118 FLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTT 177

Query: 171 GEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQ 230
           GEGDYQLVQHE+LCSM N+YEVL+FLGRGTFGQV KCWKR T EIVAIKILKNHPSYARQ
Sbjct: 178 GEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQ 237

Query: 231 GQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 290
           GQIEVSIL+RLS+ENADEYNFVR+YECFQH+NHTCLVFEMLEQNLYDFLKQNKFSPLPLK
Sbjct: 238 GQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 297

Query: 291 YIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCS 350
            IRPILQQVATAL KLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK VCS
Sbjct: 298 VIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCS 357

Query: 351 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGL 410
           TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGA EYDQIRYISQTQGL
Sbjct: 358 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGL 417

Query: 411 PAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQV 470
           P E LL+ GTK+TRFF ++ ++ +  WRLKT EEHE ETG+KSKEARKYIFN LDD+A V
Sbjct: 418 PGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHV 477

Query: 471 NMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSN 530
           N   DLEG+D+LAEKADRRE++ LLKKML IDAD RITP +TLNH FV M HLLDFPHSN
Sbjct: 478 NTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSN 537

Query: 531 HVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLA 590
           HVKSCF  M+ICK  ++  DT +  K+     VA +++  LT +F+ ++ T+ +QA   +
Sbjct: 538 HVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFT-KIGTLRSQALTTS 596

Query: 591 SSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQ 650
           + S                                 V   G+ LQ GT Q     D FQQ
Sbjct: 597 AHS---------------------------------VVHHGIPLQAGTAQFGCG-DAFQQ 622

Query: 651 TFIVCPPAFQTGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMV 709
           T I+CPPA Q G+ AT  K + + +R+DN VP+V QAPA QPLQI+ GVL+Q        
Sbjct: 623 TLIICPPAIQ-GIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQ-------- 673

Query: 710 ATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVA 769
                                                  W G TQQ+L+P+ WQQ+  +A
Sbjct: 674 --------------------------------------TWSGRTQQMLVPA-WQQVTPLA 694

Query: 770 LHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGV 829
                  T +  E++    +L DW    S  N Y+++M QP LLTN +TL+  QP++VG+
Sbjct: 695 ----PATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQP-LLTNQITLSAPQPVSVGI 749

Query: 830 AHVVRQQQSSSLPSKKNKQ---------------SAPVSSK----------SSLDVLPSQ 864
           AHVV  Q ++   +KKNKQ               SA +S K          S ++   +Q
Sbjct: 750 AHVVWPQPAT---TKKNKQCQNRSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQ 806

Query: 865 VYSLVGSSPLRTTSSYNSLVPVQD-QHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPS 923
                  +   T+   +S   V D Q Q III D+PSP VSVITI SDTDEEE ++    
Sbjct: 807 NSEGEARNCCETSIRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSL 866

Query: 924 SSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGP 972
                         T+N   D   SLSSP ST + S+   +S S  + P
Sbjct: 867 RECKGSLDCEACQSTLN--IDRMCSLSSPDSTLSTSSSGQSSPSPCKRP 913


>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
           [Homo sapiens]
          Length = 1215

 Score =  857 bits (2213), Expect = 0.0
 Identities = 519/1030 (50%), Positives = 633/1030 (61%), Gaps = 154/1030 (14%)

Query: 1   MASQLQVFSPP--SVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTL----PATQG 54
           MASQ+ V+ P      SSAFCS KKLK+EPS   V  + +  + Y + +      P T+G
Sbjct: 1   MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC-VFQERNYPRTYVNGRNFGNSHPPTKG 59

Query: 55  QANSSHQVANFNIP-AYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVS 113
            A  +     FN P  ++  L   A  +++        +  A  +  Q+ Q    R+ + 
Sbjct: 60  SAFQTK--IPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLH 117

Query: 114 LLEPYQKCGLKRKSEEVDSNGS-VQIIEEHPPLMLQNRTVVGAAATTTTVTT--KSSSSS 170
            LE  Q+CGLKRKSEE+D++ S +QI++E   L    +T +G   T  T TT  K + ++
Sbjct: 118 FLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTT 177

Query: 171 GEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQ 230
           GEGDYQLVQHE+LCSM N+YEVL+FLGRGTFGQV KCWKR T EIVAIKILKNHPSYARQ
Sbjct: 178 GEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQ 237

Query: 231 GQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 290
           GQIEVSIL+RLS+ENADEYNFVR+YECFQH+NHTCLVFEMLEQNLYDFLKQNKFSPLPLK
Sbjct: 238 GQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 297

Query: 291 YIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCS 350
            IRPILQQVATAL KLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK VCS
Sbjct: 298 VIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCS 357

Query: 351 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGL 410
           TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGA EYDQIRYISQTQGL
Sbjct: 358 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGL 417

Query: 411 PAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQV 470
           P E LL+ GTK+TRFF ++ ++ +  WRLKT EEHE ETG+KSKEARKYIFN LDD+A V
Sbjct: 418 PGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHV 477

Query: 471 NMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSN 530
           N   DLEG+D+LAEKADRRE++ LLKKML IDAD RITP +TLNH FV M HLLDFPHSN
Sbjct: 478 NTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSN 537

Query: 531 HVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLA 590
           HVKSCF  M+ICK  ++  DT +  K+     VA +++  LT +F+ ++ T+ +QA   +
Sbjct: 538 HVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFT-KIGTLRSQALTTS 596

Query: 591 SSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQ 650
           + S                                 V   G+ LQ GT Q     D FQQ
Sbjct: 597 AHS---------------------------------VVHHGIPLQAGTAQFGCG-DAFQQ 622

Query: 651 TFIVCPPAFQTGLQATT-KHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMV 709
           T I+CPPA Q G+ AT  K + + +R+DN VP+V QAPA QPLQI+ GVL+         
Sbjct: 623 TLIICPPAIQ-GIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLS--------- 672

Query: 710 ATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVA 769
                                                Q W G TQQ+L+P+ WQQ+  +A
Sbjct: 673 -------------------------------------QTWSGRTQQMLVPA-WQQVTPLA 694

Query: 770 LHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGV 829
                  T +  E++    +L DW    S  N Y+++M QP LLTN +TL+  QP++VG+
Sbjct: 695 ----PATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQP-LLTNQITLSAPQPVSVGI 749

Query: 830 AHVVRQQQSSSLPSKKNKQ------------------------------------SAPVS 853
           AHVV  Q ++   +KKNKQ                                    SA +S
Sbjct: 750 AHVVWPQPAT---TKKNKQCQNRGILVKLMEWEPGREEINAFSWSNSLQNTNIPHSAFIS 806

Query: 854 SK----------SSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQD-QHQPIIIPDTPSPP 902
            K          S ++   +Q       +   T+   +S   V D Q Q III D+PSP 
Sbjct: 807 PKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSDKQRQTIIIADSPSPA 866

Query: 903 VSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALR 962
           VSVITI SDTDEEE ++                  T+N   D   SLSSP ST + S+  
Sbjct: 867 VSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLN--IDRMCSLSSPDSTLSTSSSG 924

Query: 963 GNSGSVLEGP 972
            +S S  + P
Sbjct: 925 QSSPSPCKRP 934


>gi|169171014 PREDICTED: similar to homeodomain interacting protein
           kinase 2 [Homo sapiens]
          Length = 460

 Score =  508 bits (1309), Expect = e-144
 Identities = 263/364 (72%), Positives = 300/364 (82%), Gaps = 8/364 (2%)

Query: 1   MASQLQVFSPPSVSSSAFCSAKKLKIEPSG-WDVSGQSSNDKYYTHSKTLPATQGQA--- 56
           MAS +QVFSP ++ SSAFCS KKLKIEPS  WD++G  S+ K Y+ SK +P +Q      
Sbjct: 8   MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV 67

Query: 57  NSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLE 116
           ++S  V N ++P Y+Q ++ P  +  HIVVT+A SS S           L  RS VSLL+
Sbjct: 68  STSLPVPNPSLP-YEQTIVFPG-STGHIVVTSA-SSTSVTGQVLGGPHNLMRRSTVSLLD 124

Query: 117 PYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRT-VVGAAATTTTVTTKSSSSSGEGDY 175
            YQKCGLKRKSEE+++  SVQIIEEHPP++  N +    A ATT+T T+K+S S+ EGDY
Sbjct: 125 TYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDY 184

Query: 176 QLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEV 235
           QLVQHE+LCSMTN+YEVLEFLGRGTFGQV KCWKR T EIVAIKILKNHPSYARQGQIEV
Sbjct: 185 QLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEV 244

Query: 236 SILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPI 295
           SIL+RLS+E+AD+YNFVR+YECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRP+
Sbjct: 245 SILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPV 304

Query: 296 LQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQS 355
           LQQVATALMKLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHVSKAVCSTYLQS
Sbjct: 305 LQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQS 364

Query: 356 RYYR 359
           RYYR
Sbjct: 365 RYYR 368


>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
          Length = 616

 Score =  333 bits (854), Expect = 5e-91
 Identities = 177/356 (49%), Positives = 238/356 (66%), Gaps = 10/356 (2%)

Query: 185 SMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSE 244
           S T+ Y+++E LG+GTFG+VAK W+RST E+VAIKILKN     R  + E+ +L  +   
Sbjct: 6   SETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGL 65

Query: 245 NADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALM 304
           + +E + +R  E F       LVFE+LEQNL++F K+N F+PLP ++IR +  QV TAL 
Sbjct: 66  DPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALA 125

Query: 305 KLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKA--VCSTYLQSRYYRAPE 362
           +LK L +IHADLKPENIMLVD  R P+RVKVIDFGSAS  S+   V   Y+QSR+YRAPE
Sbjct: 126 RLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185

Query: 363 IILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKT 422
           I+LGLPFCE +D+WSLGCV+AEL LGWPLYPG +EYDQ+RYI +TQGLP  +LL A  K 
Sbjct: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245

Query: 423 TRFFNRD--PNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMST-----D 475
             FF R+  P+   P W+LK+  ++  ET ++  E RKY+   LD +  VN  +      
Sbjct: 246 HHFFKRNPHPDAANP-WQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLT 304

Query: 476 LEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNH 531
               + LAE AD +  ++L+K+MLT ++ +RI+P   L H FV+M  L     + H
Sbjct: 305 FPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360


>gi|169171552 PREDICTED: similar to homeodomain interacting protein
           kinase 3 [Homo sapiens]
          Length = 264

 Score =  293 bits (749), Expect = 8e-79
 Identities = 157/255 (61%), Positives = 192/255 (75%), Gaps = 8/255 (3%)

Query: 1   MASQLQVFSPPSVSSSAFCSAKKLKIEPSG-WDVSGQSSNDKYYTHSKTLPATQGQA--- 56
           MAS +QVFSP ++ SSAFCS KKLKIEPS  WD++G  S+ K Y+ SK +P +Q      
Sbjct: 1   MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTV 60

Query: 57  NSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLE 116
           ++S  V N ++P Y+Q ++ P  +  HIVVT+A SS S           L  RS VSLL+
Sbjct: 61  STSLPVPNPSLP-YEQTIVFPG-STGHIVVTSA-SSTSVTGQVLGGPHNLMRRSTVSLLD 117

Query: 117 PYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRT-VVGAAATTTTVTTKSSSSSGEGDY 175
            YQKCGLKRKSEE+++  SVQIIEEHPP++  N +    A ATT+T T+K+S S+ EGDY
Sbjct: 118 TYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDY 177

Query: 176 QLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEV 235
           QLVQHE+LCSMTN+YEVLEFLGRGTFGQV KCWKR T EIVAIKILKNHPSYARQGQIEV
Sbjct: 178 QLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEV 237

Query: 236 SILSRLSSENADEYN 250
           SIL+RLS+E+AD+YN
Sbjct: 238 SILARLSTESADDYN 252


>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 5 [Homo sapiens]
          Length = 529

 Score =  221 bits (564), Expect = 2e-57
 Identities = 131/339 (38%), Positives = 191/339 (56%), Gaps = 22/339 (6%)

Query: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248
           YE+   +G+G+FGQV K + R  +E VAIKI+KN  ++  Q QIEV +L  ++  + + +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218

Query: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308
           Y  V     F  +NH CLVFEML  NLYD L+   F  + L   R   QQ+ TAL+ L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278

Query: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335

Query: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426
           +P+  AIDMWSLGC++ E+  G PL+ GA+E DQ+  I +  G+P  ++L    K  +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

Query: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEK- 485
            + P+     W LK  ++ + E   K    RK + N L       + T   G     E  
Sbjct: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443

Query: 486 ---ADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521
              AD  ++ DL+ +ML  D   RI P   L H F   T
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482


>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 4 [Homo sapiens]
          Length = 540

 Score =  221 bits (564), Expect = 2e-57
 Identities = 131/339 (38%), Positives = 191/339 (56%), Gaps = 22/339 (6%)

Query: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248
           YE+   +G+G+FGQV K + R  +E VAIKI+KN  ++  Q QIEV +L  ++  + + +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218

Query: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308
           Y  V     F  +NH CLVFEML  NLYD L+   F  + L   R   QQ+ TAL+ L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278

Query: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335

Query: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426
           +P+  AIDMWSLGC++ E+  G PL+ GA+E DQ+  I +  G+P  ++L    K  +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

Query: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEK- 485
            + P+     W LK  ++ + E   K    RK + N L       + T   G     E  
Sbjct: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443

Query: 486 ---ADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521
              AD  ++ DL+ +ML  D   RI P   L H F   T
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482


>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 3 [Homo sapiens]
          Length = 584

 Score =  221 bits (564), Expect = 2e-57
 Identities = 131/339 (38%), Positives = 191/339 (56%), Gaps = 22/339 (6%)

Query: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248
           YE+   +G+G+FGQV K + R  +E VAIKI+KN  ++  Q QIEV +L  ++  + + +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218

Query: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308
           Y  V     F  +NH CLVFEML  NLYD L+   F  + L   R   QQ+ TAL+ L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278

Query: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335

Query: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426
           +P+  AIDMWSLGC++ E+  G PL+ GA+E DQ+  I +  G+P  ++L    K  +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

Query: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEK- 485
            + P+     W LK  ++ + E   K    RK + N L       + T   G     E  
Sbjct: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443

Query: 486 ---ADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521
              AD  ++ DL+ +ML  D   RI P   L H F   T
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482


>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 2 [Homo sapiens]
          Length = 754

 Score =  221 bits (564), Expect = 2e-57
 Identities = 131/339 (38%), Positives = 191/339 (56%), Gaps = 22/339 (6%)

Query: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248
           YE+   +G+G+FGQV K + R  +E VAIKI+KN  ++  Q QIEV +L  ++  + + +
Sbjct: 150 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 209

Query: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308
           Y  V     F  +NH CLVFEML  NLYD L+   F  + L   R   QQ+ TAL+ L +
Sbjct: 210 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 269

Query: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 270 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 326

Query: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426
           +P+  AIDMWSLGC++ E+  G PL+ GA+E DQ+  I +  G+P  ++L    K  +FF
Sbjct: 327 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 386

Query: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEK- 485
            + P+     W LK  ++ + E   K    RK + N L       + T   G     E  
Sbjct: 387 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 434

Query: 486 ---ADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521
              AD  ++ DL+ +ML  D   RI P   L H F   T
Sbjct: 435 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 473


>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 1 [Homo sapiens]
          Length = 763

 Score =  221 bits (564), Expect = 2e-57
 Identities = 131/339 (38%), Positives = 191/339 (56%), Gaps = 22/339 (6%)

Query: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248
           YE+   +G+G+FGQV K + R  +E VAIKI+KN  ++  Q QIEV +L  ++  + + +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218

Query: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308
           Y  V     F  +NH CLVFEML  NLYD L+   F  + L   R   QQ+ TAL+ L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278

Query: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335

Query: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426
           +P+  AIDMWSLGC++ E+  G PL+ GA+E DQ+  I +  G+P  ++L    K  +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

Query: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEK- 485
            + P+     W LK  ++ + E   K    RK + N L       + T   G     E  
Sbjct: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-LHNIL------GVETGGPGGRRAGESG 443

Query: 486 ---ADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521
              AD  ++ DL+ +ML  D   RI P   L H F   T
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482


>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform a [Homo sapiens]
          Length = 629

 Score =  218 bits (556), Expect = 2e-56
 Identities = 126/339 (37%), Positives = 189/339 (55%), Gaps = 22/339 (6%)

Query: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248
           YE+   +G+G+FGQV K +   T+E+VAIKI+KN  ++  Q QIE+ +L  ++  + + +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170

Query: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308
           Y  V     F  +NH CLVFE+L  NLYD L+   F  + L   R + QQ+ TAL+ L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230

Query: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287

Query: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426
            P+  AIDMWSLGC++ E+  G PL+ G++E DQ+  I +  G+P   +L    K  ++F
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347

Query: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAE-- 484
            R P  G+ L R K     EL    +    R+           + + T   G     E  
Sbjct: 348 ERLPGGGWTLRRTK-----ELRKDYQGPGTRRL-------QEVLGVQTGGPGGRRAGEPG 395

Query: 485 --KADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521
              AD   + DL+ +ML  +   RI+PL  L H F   T
Sbjct: 396 HSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRT 434


>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform c [Homo sapiens]
          Length = 601

 Score =  215 bits (548), Expect = 2e-55
 Identities = 125/335 (37%), Positives = 185/335 (55%), Gaps = 42/335 (12%)

Query: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248
           YE+   +G+G+FGQV K +   T+E+VAIKI+KN  ++  Q QIE+ +L  ++  + + +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170

Query: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308
           Y  V     F  +NH CLVFE+L  NLYD L+   F  + L   R + QQ+ TAL+ L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230

Query: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287

Query: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426
            P+  AIDMWSLGC++ E+  G PL+ G++E DQ+  I +  G+P   +L    K  ++F
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347

Query: 427 NRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKA 486
            R P  G+ L R              +KE RK                D +G        
Sbjct: 348 ERLPGGGWTLRR--------------TKELRK----------------DYQGP------G 371

Query: 487 DRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMT 521
            RR   DL+ +ML  +   RI+PL  L H F   T
Sbjct: 372 TRRLQEDLVLRMLEYEPAARISPLGALQHGFFRRT 406


>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform b [Homo sapiens]
          Length = 589

 Score =  210 bits (534), Expect = 7e-54
 Identities = 106/254 (41%), Positives = 160/254 (62%), Gaps = 6/254 (2%)

Query: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-E 248
           YE+   +G+G+FGQV K +   T+E+VAIKI+KN  ++  Q QIE+ +L  ++  + + +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170

Query: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308
           Y  V     F  +NH CLVFE+L  NLYD L+   F  + L   R + QQ+ TAL+ L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230

Query: 309 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 366
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287

Query: 367 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 426
            P+  AIDMWSLGC++ E+  G PL+ G++E DQ+  I +  G+P   +L    K  ++F
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347

Query: 427 NRDPNLGYPLWRLK 440
            R P  G+ L R K
Sbjct: 348 ERLPGGGWTLRRTK 361


>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 4 [Homo sapiens]
          Length = 520

 Score =  205 bits (522), Expect = 2e-52
 Identities = 125/356 (35%), Positives = 188/356 (52%), Gaps = 37/356 (10%)

Query: 164 TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKN 223
           +K+S     G Y  V H+    +   YEVLE +G+G+FGQVAKC      E+VA+KI++N
Sbjct: 81  SKTSFDDEHGFYLKVLHD---HIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRN 137

Query: 224 HPSYARQGQIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQN 282
              + +Q  +E+ IL  L  ++ D  YN V   + F  +NH C+ FE+L  NLY+ +K N
Sbjct: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197

Query: 283 KFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSAS 342
            F    L  +R     V   L  L    +IH DLKPENI+L    +    VKVIDFGS+ 
Sbjct: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ--KGQASVKVIDFGSSC 255

Query: 343 HVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIR 402
           +  + V  TY+QSR+YR+PE+ILG P+  AIDMWSLGC+ AEL+ G+PL+PG +E +Q+ 
Sbjct: 256 YEHQKV-YTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLA 314

Query: 403 YISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFN 462
            I +  GLP    +   ++   FF+   + G+P               I +   +K    
Sbjct: 315 CIMEVLGLPPAGFIQTASRRQTFFD---SKGFP-------------KNITNNRGKK---- 354

Query: 463 CLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFV 518
                       D +   M+ +  D   ++D L++ L  +   R+TP + L H ++
Sbjct: 355 ---------RYPDSKDLTMVLKTYD-TSFLDFLRRCLVWEPSLRMTPDQALKHAWI 400


>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
           regulated kinase 2 isoform 2 [Homo sapiens]
          Length = 601

 Score =  197 bits (501), Expect = 4e-50
 Identities = 120/350 (34%), Positives = 184/350 (52%), Gaps = 24/350 (6%)

Query: 172 EGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQG 231
           +G Y  V H+    +   YEVL+ +G+G+FGQV K +     + VA+K+++N   + RQ 
Sbjct: 207 QGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQA 263

Query: 232 QIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 290
             E+ IL  L  ++ D   N +   E F  +NH C+ FE+L  NLY+ +K+NKF    L 
Sbjct: 264 AEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLP 323

Query: 291 YIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCS 350
            +R     +   L  L    +IH DLKPENI+L    R    +KVIDFGS+ +  + V  
Sbjct: 324 LVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDFGSSCYEHQRVY- 380

Query: 351 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGL 410
           TY+QSR+YRAPE+ILG  +   IDMWSLGC++AEL  G+PL PG  E DQ+  + +  G+
Sbjct: 381 TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGM 440

Query: 411 PAEYLLSAGTKTTRFFNRDPNLGYPLWRLKT--PEEHELETGIKSKEARKYIFNCLDDMA 468
           P++ LL A  +   F +   + GYP +   T   +   +  G +S+  +           
Sbjct: 441 PSQKLLDASKRAKNFVS---SKGYPRYCTVTTLSDGSVVLNGGRSRRGK----------- 486

Query: 469 QVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFV 518
            +    +        +  D   ++D LK+ L  D   R+TP + L H ++
Sbjct: 487 -LRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 535


>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 2 isoform 1 [Homo sapiens]
          Length = 528

 Score =  197 bits (501), Expect = 4e-50
 Identities = 120/350 (34%), Positives = 184/350 (52%), Gaps = 24/350 (6%)

Query: 172 EGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQG 231
           +G Y  V H+    +   YEVL+ +G+G+FGQV K +     + VA+K+++N   + RQ 
Sbjct: 134 QGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQA 190

Query: 232 QIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 290
             E+ IL  L  ++ D   N +   E F  +NH C+ FE+L  NLY+ +K+NKF    L 
Sbjct: 191 AEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLP 250

Query: 291 YIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCS 350
            +R     +   L  L    +IH DLKPENI+L    R    +KVIDFGS+ +  + V  
Sbjct: 251 LVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDFGSSCYEHQRVY- 307

Query: 351 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGL 410
           TY+QSR+YRAPE+ILG  +   IDMWSLGC++AEL  G+PL PG  E DQ+  + +  G+
Sbjct: 308 TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGM 367

Query: 411 PAEYLLSAGTKTTRFFNRDPNLGYPLWRLKT--PEEHELETGIKSKEARKYIFNCLDDMA 468
           P++ LL A  +   F +   + GYP +   T   +   +  G +S+  +           
Sbjct: 368 PSQKLLDASKRAKNFVS---SKGYPRYCTVTTLSDGSVVLNGGRSRRGK----------- 413

Query: 469 QVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFV 518
            +    +        +  D   ++D LK+ L  D   R+TP + L H ++
Sbjct: 414 -LRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 462


>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 3 isoform b [Homo sapiens]
          Length = 568

 Score =  192 bits (489), Expect = 1e-48
 Identities = 115/333 (34%), Positives = 178/333 (53%), Gaps = 21/333 (6%)

Query: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSEN-ADE 248
           YEVL+ +G+G+FGQVA+ +    ++ VA+K+++N   + RQ   E+ IL  L  ++    
Sbjct: 189 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 248

Query: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308
            N +   E F  +NH C+ FE+L  +LY+ +K+NKF    ++ +R   Q +  +L  L  
Sbjct: 249 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 308

Query: 309 LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP 368
             +IH DLKPENI+L    R     KVIDFGS+    + +  TY+QSR+YRAPEIILG  
Sbjct: 309 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGSR 365

Query: 369 FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNR 428
           +   ID+WS GC++AEL  G PL+PG  E DQ+  + +  G+P   LL    +   F N 
Sbjct: 366 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN- 424

Query: 429 DPNLGYPLWRLKTPEE--HELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKA 486
             + G P +   T +     +  G +S+  +K            +  T L+G D      
Sbjct: 425 --SKGIPRYCSVTTQADGRVVLVGGRSRRGKK-----RGPPGSKDWGTALKGCDDYL--- 474

Query: 487 DRREYIDLLKKMLTIDADKRITPLKTLNHQFVT 519
               +I+ LK+ L  D   R+TP + L H +++
Sbjct: 475 ----FIEFLKRCLHWDPSARLTPAQALRHPWIS 503


>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 3 isoform a [Homo sapiens]
          Length = 588

 Score =  192 bits (489), Expect = 1e-48
 Identities = 115/333 (34%), Positives = 178/333 (53%), Gaps = 21/333 (6%)

Query: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSEN-ADE 248
           YEVL+ +G+G+FGQVA+ +    ++ VA+K+++N   + RQ   E+ IL  L  ++    
Sbjct: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268

Query: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308
            N +   E F  +NH C+ FE+L  +LY+ +K+NKF    ++ +R   Q +  +L  L  
Sbjct: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328

Query: 309 LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP 368
             +IH DLKPENI+L    R     KVIDFGS+    + +  TY+QSR+YRAPEIILG  
Sbjct: 329 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGSR 385

Query: 369 FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNR 428
           +   ID+WS GC++AEL  G PL+PG  E DQ+  + +  G+P   LL    +   F N 
Sbjct: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN- 444

Query: 429 DPNLGYPLWRLKTPEE--HELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKA 486
             + G P +   T +     +  G +S+  +K            +  T L+G D      
Sbjct: 445 --SKGIPRYCSVTTQADGRVVLVGGRSRRGKK-----RGPPGSKDWGTALKGCDDYL--- 494

Query: 487 DRREYIDLLKKMLTIDADKRITPLKTLNHQFVT 519
               +I+ LK+ L  D   R+TP + L H +++
Sbjct: 495 ----FIEFLKRCLHWDPSARLTPAQALRHPWIS 523


>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
          Length = 526

 Score =  166 bits (419), Expect = 1e-40
 Identities = 110/371 (29%), Positives = 187/371 (50%), Gaps = 49/371 (13%)

Query: 164 TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWK-RSTKEIVAIKILK 222
           T+S     EG       ++L +    YE+++ LG G FG+V +C   ++    VA+KI+K
Sbjct: 180 TRSVEDDEEGHLICQSGDVLSAR---YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK 236

Query: 223 NHPSYARQGQIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ 281
           N   Y    + E+ +L  L++ + +  +  V+  E F+H  H C+VFE+L  + YDF+K+
Sbjct: 237 NVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKE 296

Query: 282 NKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVD---------PVRQPYR 332
           N F P  L +IR +  Q+  ++  L S  L H DLKPENI+ V           +++  R
Sbjct: 297 NGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDER 356

Query: 333 ------VKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELF 386
                 +KV+DFGSA++  +   ST + +R+YRAPE+IL L + +  D+WS+GC++ E +
Sbjct: 357 TLINPDIKVVDFGSATYDDEH-HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYY 415

Query: 387 LGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHE 446
           LG+ ++P     + +  + +  G   ++++   T+  ++F+ D        RL   E   
Sbjct: 416 LGFTVFPTHDSKEHLAMMERILGPLPKHMIQK-TRKRKYFHHD--------RLDWDEH-- 464

Query: 447 LETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKR 506
                    A +Y+      + +  +S D+E               DL++KML  D  KR
Sbjct: 465 -------SSAGRYVSRRCKPLKEFMLSQDVE----------HERLFDLIQKMLEYDPAKR 507

Query: 507 ITPLKTLNHQF 517
           IT  + L H F
Sbjct: 508 ITLREALKHPF 518


>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
          Length = 484

 Score =  166 bits (419), Expect = 1e-40
 Identities = 110/371 (29%), Positives = 187/371 (50%), Gaps = 49/371 (13%)

Query: 164 TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWK-RSTKEIVAIKILK 222
           T+S     EG       ++L +    YE+++ LG G FG+V +C   ++    VA+KI+K
Sbjct: 138 TRSVEDDEEGHLICQSGDVLSAR---YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK 194

Query: 223 NHPSYARQGQIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ 281
           N   Y    + E+ +L  L++ + +  +  V+  E F+H  H C+VFE+L  + YDF+K+
Sbjct: 195 NVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKE 254

Query: 282 NKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVD---------PVRQPYR 332
           N F P  L +IR +  Q+  ++  L S  L H DLKPENI+ V           +++  R
Sbjct: 255 NGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDER 314

Query: 333 ------VKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELF 386
                 +KV+DFGSA++  +   ST + +R+YRAPE+IL L + +  D+WS+GC++ E +
Sbjct: 315 TLINPDIKVVDFGSATYDDEH-HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYY 373

Query: 387 LGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHE 446
           LG+ ++P     + +  + +  G   ++++   T+  ++F+ D        RL   E   
Sbjct: 374 LGFTVFPTHDSKEHLAMMERILGPLPKHMIQK-TRKRKYFHHD--------RLDWDEH-- 422

Query: 447 LETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKR 506
                    A +Y+      + +  +S D+E               DL++KML  D  KR
Sbjct: 423 -------SSAGRYVSRRCKPLKEFMLSQDVE----------HERLFDLIQKMLEYDPAKR 465

Query: 507 ITPLKTLNHQF 517
           IT  + L H F
Sbjct: 466 ITLREALKHPF 476


>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
          Length = 1007

 Score =  165 bits (418), Expect = 2e-40
 Identities = 115/357 (32%), Positives = 183/357 (51%), Gaps = 29/357 (8%)

Query: 169  SSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRS-TKEIVAIKILKNHPSY 227
            +  EG Y++   E+L      Y V  + G+G F  V +    +   + VA+KI++N+   
Sbjct: 669  TDAEGYYRVNIGEVL---DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELM 725

Query: 228  ARQGQIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQ-NKFS 285
             + G  E+  L +L+  + D+ ++ +R +  F HK H CLVFE L  NL + LK+  K  
Sbjct: 726  QKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDV 785

Query: 286  PLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVS 345
             L +K +R   QQ+  AL  LK   ++HAD+KP+NI++ +       +K+ DFGSASHV+
Sbjct: 786  GLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNE---SKTILKLCDFGSASHVA 842

Query: 346  KAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYIS 405
                + YL SR+YRAPEII+G  +   IDMWS+GC + EL+ G  L+PG +    ++   
Sbjct: 843  DNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAM 902

Query: 406  QTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLD 465
              +G     ++  G    + F  D NL +    +    E E  T + +    K       
Sbjct: 903  DLKGKMPNKMIRKGVFKDQHF--DQNLNFMYIEVDKVTEREKVTVMSTINPTK------- 953

Query: 466  DMAQVNMSTDLEGTDMLAEKADRREYI----DLLKKMLTIDADKRITPLKTLNHQFV 518
                 ++  DL G   L E  D+R+ +    DLL ++L +D  KRI+  + L H F+
Sbjct: 954  -----DLLADLIGCQRLPE--DQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFI 1003


>gi|10190706 CDC-like kinase 4 [Homo sapiens]
          Length = 481

 Score =  153 bits (387), Expect = 7e-37
 Identities = 99/345 (28%), Positives = 171/345 (49%), Gaps = 46/345 (13%)

Query: 190 YEVLEFLGRGTFGQVAKCWKRSTKEI-VAIKILKNHPSYARQGQIEVSILSRLSSENADE 248
           YE+++ LG G FG+V +C       + VA+KI+KN   Y    + E+ +L  L+S + + 
Sbjct: 159 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNS 218

Query: 249 -YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLK 307
            +  V+  E F H  H C+VFE+L  + YDF+K+N F P  + +IR +  Q+  ++  L 
Sbjct: 219 VFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLH 278

Query: 308 SLGLIHADLKPENIMLV---------DPVRQPYR------VKVIDFGSASHVSKAVCSTY 352
              L H DLKPENI+ V           +++  R      +KV+DFGSA++  +   ST 
Sbjct: 279 HNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEH-HSTL 337

Query: 353 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 412
           + +R+YRAPE+IL L + +  D+WS+GC++ E +LG+ ++      + +  + +  G   
Sbjct: 338 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIP 397

Query: 413 EYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNM 472
           ++++    K   F +   +     W     +EH          A +Y+      + +   
Sbjct: 398 QHMIQKTRKRKYFHHNQLD-----W-----DEH--------SSAGRYVRRRCKPLKEF-- 437

Query: 473 STDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQF 517
                   ML    +  +  DL+++ML  D  +RIT  + L H F
Sbjct: 438 --------MLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPF 474


>gi|47717134 CDC-like kinase 2 [Homo sapiens]
          Length = 498

 Score =  147 bits (371), Expect = 5e-35
 Identities = 99/345 (28%), Positives = 167/345 (48%), Gaps = 46/345 (13%)

Query: 190 YEVLEFLGRGTFGQVAKCWK-RSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADE 248
           YE++  LG GTFG+V +C   R     VA+KI+KN   Y    ++E+++L +++ ++ D 
Sbjct: 162 YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDN 221

Query: 249 YNF-VRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLK 307
            N  V+ ++ F +  H C+ FE+L  + +DFLK N + P P+  +R +  Q+  A+  L 
Sbjct: 222 KNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLH 281

Query: 308 SLGLIHADLKPENIMLVDPVRQ---------------PYRVKVIDFGSASHVSKAVCSTY 352
              L H DLKPENI+ V+   +                  V+V+DFGSA+       ST 
Sbjct: 282 DNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT-FDHEHHSTI 340

Query: 353 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 412
           + +R+YRAPE+IL L + +  D+WS+GC+I E ++G+ L+      + +  + +  G P 
Sbjct: 341 VSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILG-PI 399

Query: 413 EYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNM 472
              +   T+  ++F R    G   W   T     +      K  R+Y             
Sbjct: 400 PSRMIRKTRKQKYFYR----GRLDWDENTSAGRYVRE--NCKPLRRY------------- 440

Query: 473 STDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQF 517
                   + +E  +  +  DL++ ML  +  KR+T  + L H F
Sbjct: 441 --------LTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPF 477


>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
          Length = 638

 Score =  145 bits (366), Expect = 2e-34
 Identities = 100/384 (26%), Positives = 184/384 (47%), Gaps = 53/384 (13%)

Query: 155 AAATTTTVTTKSSSSSGEGDYQLVQHEILCS----MTNSYEVLEFLGRGTFGQVAKCWKR 210
           +A++ +  ++K SS S E D +     ++C     +   YE++  LG GTFG+V +C   
Sbjct: 268 SASSRSQQSSKRSSRSVEDDKE---GHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDH 324

Query: 211 ST-KEIVAIKILKNHPSYARQGQIEVSILSRLSSENAD-EYNFVRSYECFQHKNHTCLVF 268
           +  K  VA+KI++N   Y    ++E+++L ++  ++ + ++  V   + F    H C+ F
Sbjct: 325 ARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAF 384

Query: 269 EMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVR 328
           E+L +N ++FLK+N F P PL ++R +  Q+  AL  L    L H DLKPENI+ V+   
Sbjct: 385 ELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEF 444

Query: 329 QPY---------------RVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAI 373
           +                  ++V DFGSA+       +T + +R+YR PE+IL L + +  
Sbjct: 445 ETLYNEHKSCEEKSVKNTSIRVADFGSAT-FDHEHHTTIVATRHYRPPEVILELGWAQPC 503

Query: 374 DMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLG 433
           D+WS+GC++ E + G+ L+      + +  + +  G    +++    K   F+      G
Sbjct: 504 DVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYK-----G 558

Query: 434 YPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYID 493
             +W   + +   ++   K  ++                        ML +  +  +  D
Sbjct: 559 GLVWDENSSDGRYVKENCKPLKSY-----------------------MLQDSLEHVQLFD 595

Query: 494 LLKKMLTIDADKRITPLKTLNHQF 517
           L+++ML  D  +RIT  + L H F
Sbjct: 596 LMRRMLEFDPAQRITLAEALLHPF 619


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.128    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,975,201
Number of Sequences: 37866
Number of extensions: 1903470
Number of successful extensions: 8620
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 432
Number of HSP's successfully gapped in prelim test: 428
Number of HSP's that attempted gapping in prelim test: 6295
Number of HSP's gapped (non-prelim): 1641
length of query: 1075
length of database: 18,247,518
effective HSP length: 113
effective length of query: 962
effective length of database: 13,968,660
effective search space: 13437850920
effective search space used: 13437850920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.