BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens] (766 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens] 1545 0.0 gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens] 1450 0.0 gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens] 1331 0.0 gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens] 1030 0.0 gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens] 1030 0.0 gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 115 2e-25 gi|150456432 unc-51-like kinase 3 [Homo sapiens] 115 2e-25 gi|93004081 polo-like kinase 2 [Homo sapiens] 113 8e-25 gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 111 3e-24 gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 111 3e-24 gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 110 4e-24 gi|62865643 aurora kinase C isoform 3 [Homo sapiens] 109 8e-24 gi|62865641 aurora kinase C isoform 2 [Homo sapiens] 109 8e-24 gi|62865639 aurora kinase C isoform 1 [Homo sapiens] 109 8e-24 gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 108 2e-23 gi|121114283 polo-like kinase 4 [Homo sapiens] 107 3e-23 gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 107 5e-23 gi|23308722 TTK protein kinase [Homo sapiens] 106 7e-23 gi|217330634 serine/threonine kinase 36 [Homo sapiens] 105 1e-22 gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 105 2e-22 gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 105 2e-22 gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 104 4e-22 gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 104 4e-22 gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 104 4e-22 gi|156105707 SNF related kinase [Homo sapiens] 104 4e-22 gi|156105705 SNF related kinase [Homo sapiens] 104 4e-22 gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 103 5e-22 gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 103 5e-22 gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 103 5e-22 gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 103 5e-22 >gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens] Length = 766 Score = 1545 bits (4001), Expect = 0.0 Identities = 766/766 (100%), Positives = 766/766 (100%) Query: 1 MSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQ 60 MSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQ Sbjct: 1 MSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQ 60 Query: 61 ELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESS 120 ELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESS Sbjct: 61 ELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESS 120 Query: 121 RGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTP 180 RGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTP Sbjct: 121 RGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTP 180 Query: 181 SSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRID 240 SSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRID Sbjct: 181 SSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRID 240 Query: 241 DLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRL 300 DLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRL Sbjct: 241 DLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRL 300 Query: 301 GHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAP 360 GHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAP Sbjct: 301 GHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAP 360 Query: 361 STNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAE 420 STNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAE Sbjct: 361 STNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAE 420 Query: 421 LERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQR 480 LERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQR Sbjct: 421 LERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQR 480 Query: 481 YAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEY 540 YAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEY Sbjct: 481 YAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEY 540 Query: 541 CEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTAC 600 CEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTAC Sbjct: 541 CEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTAC 600 Query: 601 GEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSV 660 GEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSV Sbjct: 601 GEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSV 660 Query: 661 GVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKE 720 GVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKE Sbjct: 661 GVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKE 720 Query: 721 DRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 766 DRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY Sbjct: 721 DRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 766 >gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens] Length = 718 Score = 1450 bits (3754), Expect = 0.0 Identities = 718/718 (100%), Positives = 718/718 (100%) Query: 49 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 108 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE Sbjct: 1 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 60 Query: 109 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 168 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI Sbjct: 61 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 120 Query: 169 RSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNK 228 RSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNK Sbjct: 121 RSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNK 180 Query: 229 IQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLS 288 IQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLS Sbjct: 181 IQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLS 240 Query: 289 SREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAK 348 SREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAK Sbjct: 241 SREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAK 300 Query: 349 RKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLG 408 RKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLG Sbjct: 301 RKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLG 360 Query: 409 HLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFS 468 HLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFS Sbjct: 361 HLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFS 420 Query: 469 EVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS 528 EVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS Sbjct: 421 EVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS 480 Query: 529 LDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLK 588 LDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLK Sbjct: 481 LDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLK 540 Query: 589 PGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEP 648 PGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEP Sbjct: 541 PGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEP 600 Query: 649 PKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAK 708 PKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAK Sbjct: 601 PKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAK 660 Query: 709 AFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 766 AFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY Sbjct: 661 AFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 718 >gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens] Length = 670 Score = 1331 bits (3444), Expect = 0.0 Identities = 656/657 (99%), Positives = 657/657 (100%) Query: 110 ETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR 169 +TPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR Sbjct: 14 KTPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR 73 Query: 170 SPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKI 229 SPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKI Sbjct: 74 SPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKI 133 Query: 230 QDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS 289 QDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS Sbjct: 134 QDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS 193 Query: 290 REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKR 349 REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKR Sbjct: 194 REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKR 253 Query: 350 KPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGH 409 KPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGH Sbjct: 254 KPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGH 313 Query: 410 LKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSE 469 LKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSE Sbjct: 314 LKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSE 373 Query: 470 VYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL 529 VYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL Sbjct: 374 VYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL 433 Query: 530 DTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKP 589 DTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKP Sbjct: 434 DTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKP 493 Query: 590 GNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPP 649 GNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPP Sbjct: 494 GNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPP 553 Query: 650 KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA 709 KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA Sbjct: 554 KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA 613 Query: 710 FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 766 FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY Sbjct: 614 FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 670 >gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens] Length = 750 Score = 1030 bits (2664), Expect = 0.0 Identities = 551/773 (71%), Positives = 606/773 (78%), Gaps = 88/773 (11%) Query: 49 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 108 M+ELHSLDPRRQELLEARFTGV +K N+ESSN S S+GSLSDKE Sbjct: 2 MEELHSLDPRRQELLEARFTGVGV------------SKGPLNSESSNQSLCSVGSLSDKE 49 Query: 109 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGN--GSSPVRG--- 163 ETPEKKQ++ R RKRKAE E+SQGK RGHKISDYFE+ GG+ G+SP R Sbjct: 50 VETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFEFAGGSAPGTSPGRSVPP 106 Query: 164 -------------IPPAIRSPQ-----NSHSHSTPSSSVRP------------------- 186 +P + P ++ +T S P Sbjct: 107 VARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQ 166 Query: 187 --------------NSPSPTALAFGDHPIVQPKQLSFKIIQT--DLTMLKLAALESNKIQ 230 NSPS T +H KQ+S + QT DLT+ K++ALE++K Sbjct: 167 RGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNS 226 Query: 231 DLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSR 290 DLEKKEGRIDDLLRANCDLRRQIDEQQK+LEKYKERLN+C++MSKKLLIEKS QEK++ R Sbjct: 227 DLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACR 286 Query: 291 EKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRK 350 +KSMQDRLRLGHFTTVRHGASFTEQWTDG+AFQNL+KQQE +N QRE+IERQRK+LAKRK Sbjct: 287 DKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRK 346 Query: 351 PPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHL 410 PP QAP +E KQRK+K NGAEN+ LTLAEYHEQEEIFKLRLGHL Sbjct: 347 PPAMG--QAPPATNEQKQRKSKT-NGAENET---------LTLAEYHEQEEIFKLRLGHL 394 Query: 411 KKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEV 470 KKEEAEIQAELERLERVRNLHIRELKRI+NEDNSQFKDHPTLN+RYLLLHLLGRGGFSEV Sbjct: 395 KKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEV 454 Query: 471 YKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD 530 YKAFDL EQRY AVKIHQLNK+WRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD Sbjct: 455 YKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD 514 Query: 531 TDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPG 590 TD+FCTVLEYCEGNDLDFYLKQHKLMSEKEARSI+MQIVNAL+YLNEIKPPIIHYDLKPG Sbjct: 515 TDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPG 574 Query: 591 NILLVDGTACGEIKITDFGLSKIMDDDSY-GVDGMDLTSQGAGTYWYLPPECFVVGKEPP 649 NILLV+GTACGEIKITDFGLSKIMDDDSY VDGM+LTSQGAGTYWYLPPECFVVGKEPP Sbjct: 575 NILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPP 634 Query: 650 KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA 709 KISNKVDVWSVGVIF+QCLYGRKPFGHNQSQQDILQENTILKATEVQFP KPVV+ EAKA Sbjct: 635 KISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKA 694 Query: 710 FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSS 762 FIRRCLAYRKEDR DV QLA DPYLLPH+R+S S+ + AG + T +S+ Sbjct: 695 FIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSS--PAGAAIASTSGASN 745 >gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens] Length = 718 Score = 1030 bits (2662), Expect = 0.0 Identities = 544/744 (73%), Positives = 598/744 (80%), Gaps = 62/744 (8%) Query: 49 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 108 M+ELHSLDPRRQELLEARFTGV +K N+ESSN S S+GSLSDKE Sbjct: 2 MEELHSLDPRRQELLEARFTGVGV------------SKGPLNSESSNQSLCSVGSLSDKE 49 Query: 109 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 168 ETPEKKQ++ R RKRKAE E+SQGK RGHKISDYFE + P+ G+ + Sbjct: 50 VETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFERRV---EQPLYGLDGSA 103 Query: 169 RSPQNSHSHSTPSS---------------------------SVRPNSPSPTALAFGDHPI 201 + P+ S + NSPS T +H Sbjct: 104 AKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSC 163 Query: 202 VQPKQLSFKIIQT--DLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKL 259 KQ+S + QT DLT+ K++ALE++K DLEKKEGRIDDLLRANCDLRRQIDEQQK+ Sbjct: 164 SSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKM 223 Query: 260 LEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDG 319 LEKYKERLN+C++MSKKLLIEKS QEK++ R+KSMQDRLRLGHFTTVRHGASFTEQWTDG Sbjct: 224 LEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDG 283 Query: 320 FAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAEN 379 +AFQNL+KQQE +N QRE+IERQRK+LAKRKPP QAP +E KQRK+K NGAEN Sbjct: 284 YAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG--QAPPATNEQKQRKSKT-NGAEN 340 Query: 380 DPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIN 439 + LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRI+ Sbjct: 341 ET---------LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIH 391 Query: 440 NEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE 499 NEDNSQFKDHPTLN+RYLLLHLLGRGGFSEVYKAFDL EQRY AVKIHQLNK+WRDEKKE Sbjct: 392 NEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE 451 Query: 500 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEK 559 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTD+FCTVLEYCEGNDLDFYLKQHKLMSEK Sbjct: 452 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEK 511 Query: 560 EARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSY 619 EARSI+MQIVNAL+YLNEIKPPIIHYDLKPGNILLV+GTACGEIKITDFGLSKIMDDDSY Sbjct: 512 EARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSY 571 Query: 620 -GVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQ 678 VDGM+LTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF+QCLYGRKPFGHNQ Sbjct: 572 NSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQ 631 Query: 679 SQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHM 738 SQQDILQENTILKATEVQFP KPVV+ EAKAFIRRCLAYRKEDR DV QLA DPYLLPH+ Sbjct: 632 SQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 691 Query: 739 RRSNSSGNLHMAGLTASPTPPSSS 762 R+S S+ + AG + T +S+ Sbjct: 692 RKSVSTSS--PAGAAIASTSGASN 713 >gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] Length = 661 Score = 115 bits (288), Expect = 2e-25 Identities = 87/279 (31%), Positives = 134/279 (48%), Gaps = 27/279 (9%) Query: 452 LNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRI 511 L RY L LG+G + +V +A + + R A+K + +K K E H RE I Sbjct: 51 LKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKI----KDEQDMVHIRREIEI 106 Query: 512 HKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNA 571 L+HP I+ +Y+ F + D ++EY +L Y+ + + +SE+E R QIV+A Sbjct: 107 MSSLNHPHIISIYEVFE-NKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSA 165 Query: 572 LRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGA 631 + Y + K ++H DLK NILL D IKI DFGLS + D + Sbjct: 166 VHYCH--KNGVVHRDLKLENILLDDNC---NIKIADFGLSNLYQKDKF-------LQTFC 213 Query: 632 GTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILK 691 G+ Y PE V G+ P +VD W++GV+ + +YG PF + I Q + Sbjct: 214 GSPLYASPE-IVNGR--PYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQ----IS 266 Query: 692 ATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLAN 730 + E + P +P S+A+ IR L + R + +AN Sbjct: 267 SGEYREPTQP---SDARGLIRWMLMVNPDRRATIEDIAN 302 >gi|150456432 unc-51-like kinase 3 [Homo sapiens] Length = 472 Score = 115 bits (287), Expect = 2e-25 Identities = 86/299 (28%), Positives = 139/299 (46%), Gaps = 27/299 (9%) Query: 450 PTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREY 509 P + ++L LG G ++ VYKA+ + R KS EN E Sbjct: 8 PPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENL----LTEI 63 Query: 510 RIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIV 569 I K + HP IV+L D F D+D ++E+C G DL ++ +++ EK AR + Q+ Sbjct: 64 EILKGIRHPHIVQLKD-FQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLA 122 Query: 570 NALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMD--DDSYGVDGMDLT 627 +AL++L+E I H DLKP NILL +K+ DFG ++ M D+ + + G L Sbjct: 123 SALQFLHERN--ISHLDLKPQNILL-SSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL- 178 Query: 628 SQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQEN 687 Y+ PE + +VD+WS+GVI ++ L+G+ PF + E Sbjct: 179 --------YMAPEMVC----QRQYDARVDLWSMGVILYEALFGQPPFASRSFSE---LEE 223 Query: 688 TILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL-LPHMRRSNSSG 745 I ++ P++P++S + + ++R L R P++ L HM S G Sbjct: 224 KIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLG 282 >gi|93004081 polo-like kinase 2 [Homo sapiens] Length = 685 Score = 113 bits (282), Expect = 8e-25 Identities = 86/291 (29%), Positives = 139/291 (47%), Gaps = 36/291 (12%) Query: 450 PTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREY 509 PT +RY +LG+GGF++ Y+ DL + A KI ++ + ++E K E Sbjct: 76 PTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDK----EI 131 Query: 510 RIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIV 569 +H+ L H +V+ Y YF D + +LEYC + LK K+++E E R + QIV Sbjct: 132 ELHRILHHKHVVQFYHYFE-DKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIV 190 Query: 570 NALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQ 629 + L+YL+E I+H DLK GN + + E+K+ DFGL+ ++ + + Sbjct: 191 SGLKYLHE--QEILHRDLKLGNFFINEAM---ELKVGDFGLAARLEPLEHRRRTI----- 240 Query: 630 GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTI 689 GT YL PE V+ K+ + D+W++G + + L GR PF E T Sbjct: 241 -CGTPNYLSPE--VLNKQGHGCES--DIWALGCVMYTMLLGRPPF-----------ETTN 284 Query: 690 LKAT-----EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLL 735 LK T E ++ + + + AK I L+ EDR + + + L Sbjct: 285 LKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFL 335 >gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] Length = 586 Score = 111 bits (277), Expect = 3e-24 Identities = 91/284 (32%), Positives = 137/284 (48%), Gaps = 14/284 (4%) Query: 452 LNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE-NYHKHACREYR 510 L + Y++ LG G EV AF+ + A+KI K +E + + E Sbjct: 259 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 318 Query: 511 IHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVN 570 I K+L+HP I+K+ ++F D + + VLE EG +L + +K + E + Q++ Sbjct: 319 ILKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 376 Query: 571 ALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQG 630 A++YL+E IIH DLKP N+LL IKITDFG SKI+ + S L Sbjct: 377 AVQYLHE--NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS-------LMRTL 427 Query: 631 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTIL 690 GT YL PE +V + VD WS+GVI F CL G PF +++Q + + T Sbjct: 428 CGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSG 486 Query: 691 KATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734 K + V VS +A +++ L + RF + P+L Sbjct: 487 KYNFIP-EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 529 >gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] Length = 543 Score = 111 bits (277), Expect = 3e-24 Identities = 91/284 (32%), Positives = 137/284 (48%), Gaps = 14/284 (4%) Query: 452 LNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE-NYHKHACREYR 510 L + Y++ LG G EV AF+ + A+KI K +E + + E Sbjct: 216 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 275 Query: 511 IHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVN 570 I K+L+HP I+K+ ++F D + + VLE EG +L + +K + E + Q++ Sbjct: 276 ILKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 333 Query: 571 ALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQG 630 A++YL+E IIH DLKP N+LL IKITDFG SKI+ + S L Sbjct: 334 AVQYLHE--NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS-------LMRTL 384 Query: 631 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTIL 690 GT YL PE +V + VD WS+GVI F CL G PF +++Q + + T Sbjct: 385 CGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSG 443 Query: 691 KATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734 K + V VS +A +++ L + RF + P+L Sbjct: 444 KYNFIP-EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486 >gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo sapiens] Length = 476 Score = 110 bits (276), Expect = 4e-24 Identities = 86/299 (28%), Positives = 145/299 (48%), Gaps = 25/299 (8%) Query: 437 RINNEDNSQFKDHPT-LNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRD 495 R +D S +K T + + ++ + +LG G FSEV+ + A+K + + ++RD Sbjct: 3 RKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD 62 Query: 496 EKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKL 555 EN E + K++ H IV L D + T + V++ G +L + + + Sbjct: 63 SSLEN-------EIAVLKKIKHENIVTLEDIYE-STTHYYLVMQLVSGGELFDRILERGV 114 Query: 556 MSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMD 615 +EK+A ++ Q+++A++YL+E I+H DLKP N+L + +I ITDFGLSK+ Sbjct: 115 YTEKDASLVIQQVLSAVKYLHE--NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQ 172 Query: 616 DDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFG 675 + + S GT Y+ PE V+ ++P S VD WS+GVI + L G PF Sbjct: 173 N--------GIMSTACGTPGYVAPE--VLAQKP--YSKAVDCWSIGVITYILLCGYPPF- 219 Query: 676 HNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734 + + L E E + P +S AK FI L +R+ + + P++ Sbjct: 220 -YEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277 >gi|62865643 aurora kinase C isoform 3 [Homo sapiens] Length = 275 Score = 109 bits (273), Expect = 8e-24 Identities = 89/282 (31%), Positives = 138/282 (48%), Gaps = 34/282 (12%) Query: 462 LGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIV 521 LG+G F VY A ++ + V + L KS +KE RE I L HP I+ Sbjct: 15 LGKGKFGNVYLA--RLKESHFIVALKVLFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 70 Query: 522 KLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPP 581 +LY+YF D +LEY +L L++ + + E+ +I+ ++ +AL Y ++ K Sbjct: 71 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 127 Query: 582 IIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPEC 641 +IH D+KP N+LL GE+KI DFG S + S M GT YLPPE Sbjct: 128 VIHRDIKPENLLL---GFRGEVKIADFGWS--VHTPSLRRKTM------CGTLDYLPPEM 176 Query: 642 FVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF---GHNQSQQDILQENTILKATEVQFP 698 E KVD+W +GV+ ++ L G PF H+++ + IL+ +V+FP Sbjct: 177 I----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRFP 225 Query: 699 VKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRR 740 + + A+ I R L Y+ +R + Q+ P++ H RR Sbjct: 226 LSMPLG--ARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 265 >gi|62865641 aurora kinase C isoform 2 [Homo sapiens] Length = 290 Score = 109 bits (273), Expect = 8e-24 Identities = 89/282 (31%), Positives = 138/282 (48%), Gaps = 34/282 (12%) Query: 462 LGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIV 521 LG+G F VY A ++ + V + L KS +KE RE I L HP I+ Sbjct: 30 LGKGKFGNVYLA--RLKESHFIVALKVLFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 85 Query: 522 KLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPP 581 +LY+YF D +LEY +L L++ + + E+ +I+ ++ +AL Y ++ K Sbjct: 86 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 142 Query: 582 IIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPEC 641 +IH D+KP N+LL GE+KI DFG S + S M GT YLPPE Sbjct: 143 VIHRDIKPENLLL---GFRGEVKIADFGWS--VHTPSLRRKTM------CGTLDYLPPEM 191 Query: 642 FVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF---GHNQSQQDILQENTILKATEVQFP 698 E KVD+W +GV+ ++ L G PF H+++ + IL+ +V+FP Sbjct: 192 I----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRFP 240 Query: 699 VKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRR 740 + + A+ I R L Y+ +R + Q+ P++ H RR Sbjct: 241 LSMPLG--ARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 280 >gi|62865639 aurora kinase C isoform 1 [Homo sapiens] Length = 309 Score = 109 bits (273), Expect = 8e-24 Identities = 89/282 (31%), Positives = 138/282 (48%), Gaps = 34/282 (12%) Query: 462 LGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIV 521 LG+G F VY A ++ + V + L KS +KE RE I L HP I+ Sbjct: 49 LGKGKFGNVYLA--RLKESHFIVALKVLFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 104 Query: 522 KLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPP 581 +LY+YF D +LEY +L L++ + + E+ +I+ ++ +AL Y ++ K Sbjct: 105 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 161 Query: 582 IIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPEC 641 +IH D+KP N+LL GE+KI DFG S + S M GT YLPPE Sbjct: 162 VIHRDIKPENLLL---GFRGEVKIADFGWS--VHTPSLRRKTM------CGTLDYLPPEM 210 Query: 642 FVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF---GHNQSQQDILQENTILKATEVQFP 698 E KVD+W +GV+ ++ L G PF H+++ + IL+ +V+FP Sbjct: 211 I----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRFP 259 Query: 699 VKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRR 740 + + A+ I R L Y+ +R + Q+ P++ H RR Sbjct: 260 LSMPLG--ARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 299 >gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo sapiens] Length = 370 Score = 108 bits (270), Expect = 2e-23 Identities = 87/295 (29%), Positives = 145/295 (49%), Gaps = 26/295 (8%) Query: 442 DNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVK-IHQLNKSWRDEKKEN 500 + ++K + + Y +LG G FSEV A D Q+ A+K I + ++ EN Sbjct: 6 EGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMEN 65 Query: 501 YHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKE 560 E + ++ HP IV L D + + +++ G +L + + +E++ Sbjct: 66 -------EIAVLHKIKHPNIVALDDIYESGGHLYL-IMQLVSGGELFDRIVEKGFYTERD 117 Query: 561 ARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYG 620 A ++ Q+++A++YL+++ I+H DLKP N+L +I I+DFGLSK+ D S Sbjct: 118 ASRLIFQVLDAVKYLHDLG--IVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGS-- 173 Query: 621 VDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQ 680 + S GT Y+ PE V+ ++P S VD WS+GVI + L G PF ++++ Sbjct: 174 -----VLSTACGTPGYVAPE--VLAQKP--YSKAVDCWSIGVIAYILLCGYPPF-YDEND 223 Query: 681 QDILQENTILKAT-EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734 + ++ ILKA E P +S AK FIR + E RF Q P++ Sbjct: 224 AKLFEQ--ILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276 >gi|121114283 polo-like kinase 4 [Homo sapiens] Length = 970 Score = 107 bits (268), Expect = 3e-23 Identities = 86/285 (30%), Positives = 138/285 (48%), Gaps = 33/285 (11%) Query: 454 ERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHK 513 E + + +LLG+G F+ VY+A ++ A+K+ + K + E +IH Sbjct: 10 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMY----KAGMVQRVQNEVKIHC 65 Query: 514 ELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQH-KLMSEKEARSIVMQIVNAL 572 +L HP I++LY+YF D++ VLE C +++ YLK K SE EAR + QI+ + Sbjct: 66 QLKHPSILELYNYFE-DSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGM 124 Query: 573 RYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLS---KIMDDDSYGVDGMDLTSQ 629 YL+ I+H DL N+LL T IKI DFGL+ K+ + Y + Sbjct: 125 LYLH--SHGILHRDLTLSNLLL---TRNMNIKIADFGLATQLKMPHEKHYTL-------- 171 Query: 630 GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTI 689 GT Y+ PE + + + + DVWS+G +F+ L GR PF + +NT+ Sbjct: 172 -CGTPNYISPE--IATRSAHGLES--DVWSLGCMFYTLLIGRPPFDTD------TVKNTL 220 Query: 690 LKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734 K + + +S EAK I + L DR + + + P++ Sbjct: 221 NKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM 265 >gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo sapiens] Length = 688 Score = 107 bits (266), Expect = 5e-23 Identities = 93/283 (32%), Positives = 136/283 (48%), Gaps = 35/283 (12%) Query: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKI---HQLNKSWRDEKKENYHKHACREYRIH 512 Y LL +G+G F++V A + R A+KI QLN S + RE RI Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQK--------LFREVRIM 110 Query: 513 KELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNAL 572 K L+HP IVKL++ + T V+EY ++ YL H M EKEAR+ QIV+A+ Sbjct: 111 KGLNHPNIVKLFEVIETEK-TLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAV 169 Query: 573 RYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAG 632 Y ++ I+H DLK N+LL A IKI DFG S ++ + G G Sbjct: 170 HYCHQ--KNIVHRDLKAENLLL---DAEANIKIADFGFS---NEFTLG----SKLDTFCG 217 Query: 633 TYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILK 691 + Y PE F K +VD+WS+GVI + + G PF GHN + L+E + Sbjct: 218 SPPYAAPELFQGKKYD---GPEVDIWSLGVILYTLVSGSLPFDGHNLKE---LRERVLRG 271 Query: 692 ATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734 V F +S++ ++ +RR L R + Q+ D ++ Sbjct: 272 KYRVPF----YMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 310 >gi|23308722 TTK protein kinase [Homo sapiens] Length = 857 Score = 106 bits (265), Expect = 7e-23 Identities = 84/291 (28%), Positives = 143/291 (49%), Gaps = 36/291 (12%) Query: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 515 Y +L +G GG S+V++ + +Q YA +K L ++ ++ ++Y ++ + Sbjct: 525 YSILKQIGSGGSSKVFQVLNEKKQIYA-IKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 582 Query: 516 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 575 D +I++LYDY TD + ++ C DL+ +LK+ K + E +S ++ A+ + Sbjct: 583 D--KIIRLYDYEI--TDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 638 Query: 576 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 635 ++ I+H DLKP N L+VDG +K+ DFG++ M D+ V + GT Sbjct: 639 HQ--HGIVHSDLKPANFLIVDGM----LKLIDFGIANQMQPDTTSV----VKDSQVGTVN 688 Query: 636 YLPPECFVV-------GKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENT 688 Y+PPE GK KIS K DVWS+G I + YG+ PF Q I+ + + Sbjct: 689 YMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQIS 742 Query: 689 ILKAT-----EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734 L A E++FP P + + ++ CL + R + +L PY+ Sbjct: 743 KLHAIIDPNHEIEFPDIP--EKDLQDVLKCCLKRDPKQRISIPELLAHPYV 791 >gi|217330634 serine/threonine kinase 36 [Homo sapiens] Length = 1315 Score = 105 bits (263), Expect = 1e-22 Identities = 93/311 (29%), Positives = 145/311 (46%), Gaps = 28/311 (9%) Query: 454 ERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHK 513 E+Y +L ++G G F VYK Y + A+K + K R EK+ ++ RE I + Sbjct: 2 EKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKF--IPKLGRSEKE---LRNLQREIEIMR 56 Query: 514 ELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALR 573 L HP IV + D F D + V +Y EG +L L+ + E + ++I Q+V+AL Sbjct: 57 GLRHPNIVHMLDSFETDKEV-VVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALY 114 Query: 574 YLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGT 633 YL+ + I+H D+KP NILL G G IK+ DFG ++ M ++ M LTS GT Sbjct: 115 YLHSHR--ILHRDMKPQNILLAKG---GGIKLCDFGFARAMSTNT-----MVLTSI-KGT 163 Query: 634 YWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKAT 693 Y+ PE +V + P + D+WSVG I ++ G PF I Q +++ Sbjct: 164 PLYMSPE--LVEERP--YDHTADLWSVGCILYELAVGTPPF----YATSIFQLVSLILKD 215 Query: 694 EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLT 753 V++P +S K F++ L R L P++ H+ + Sbjct: 216 PVRWP--STISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPF 273 Query: 754 ASPTPPSSSII 764 S PP ++ Sbjct: 274 TSRLPPELQVL 284 >gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo sapiens] Length = 496 Score = 105 bits (261), Expect = 2e-22 Identities = 88/279 (31%), Positives = 139/279 (49%), Gaps = 29/279 (10%) Query: 459 LHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHP 518 L ++G+G F +V A + ++ AVK+ L K +KE H A R + K + HP Sbjct: 165 LKVIGKGSFGKVLLAKRKLDGKFYAVKV--LQKKIVLNRKEQKHIMAERNVLL-KNVKHP 221 Query: 519 RIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEI 578 +V L+ F T+ VL++ G +L F+L++ + E AR +I +AL YL+ I Sbjct: 222 FLVGLHYSFQT-TEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280 Query: 579 KPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLP 638 K I++ DLKP NILL + G + +TDFGL K G+ D T+ GT YL Sbjct: 281 K--IVYRDLKPENILL---DSVGHVVLTDFGLCK------EGIAISDTTTTFCGTPEYLA 329 Query: 639 PECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFP 698 PE V+ K+P N VD W +G + ++ LYG PF + + +N + K Sbjct: 330 PE--VIRKQP--YDNTVDWWCLGAVLYEMLYGLPPFYCRDVAE--MYDNILHK----PLS 379 Query: 699 VKPVVSSEAKAFIRRCLAYRKEDRF----DVHQLANDPY 733 ++P VS A + + L +++R D ++ N P+ Sbjct: 380 LRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPF 418 >gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo sapiens] Length = 496 Score = 105 bits (261), Expect = 2e-22 Identities = 88/279 (31%), Positives = 139/279 (49%), Gaps = 29/279 (10%) Query: 459 LHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHP 518 L ++G+G F +V A + ++ AVK+ L K +KE H A R + K + HP Sbjct: 165 LKVIGKGSFGKVLLAKRKLDGKFYAVKV--LQKKIVLNRKEQKHIMAERNVLL-KNVKHP 221 Query: 519 RIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEI 578 +V L+ F T+ VL++ G +L F+L++ + E AR +I +AL YL+ I Sbjct: 222 FLVGLHYSFQT-TEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280 Query: 579 KPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLP 638 K I++ DLKP NILL + G + +TDFGL K G+ D T+ GT YL Sbjct: 281 K--IVYRDLKPENILL---DSVGHVVLTDFGLCK------EGIAISDTTTTFCGTPEYLA 329 Query: 639 PECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFP 698 PE V+ K+P N VD W +G + ++ LYG PF + + +N + K Sbjct: 330 PE--VIRKQP--YDNTVDWWCLGAVLYEMLYGLPPFYCRDVAE--MYDNILHK----PLS 379 Query: 699 VKPVVSSEAKAFIRRCLAYRKEDRF----DVHQLANDPY 733 ++P VS A + + L +++R D ++ N P+ Sbjct: 380 LRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPF 418 >gi|4507831 Unc-51-like kinase 1 [Homo sapiens] Length = 1050 Score = 104 bits (259), Expect = 4e-22 Identities = 87/295 (29%), Positives = 133/295 (45%), Gaps = 42/295 (14%) Query: 461 LLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHAC---REYRIHKELDH 517 L+G G F+ V+K + H L + + K+N K +E +I KEL H Sbjct: 21 LIGHGAFAVVFKGRHREK--------HDLEVAVKCINKKNLAKSQTLLGKEIKILKELKH 72 Query: 518 PRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNE 577 IV LYD+ + + V+EYC G DL YL + +SE R + QI A+R L+ Sbjct: 73 ENIVALYDFQEMANSVYL-VMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLH- 130 Query: 578 IKPPIIHYDLKPGNILLVDGTA------CGEIKITDFGLSKIMDDDSYGVDGMDLTSQGA 631 IIH DLKP NILL + +KI DFG ++ + + + + Sbjct: 131 -SKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNM-------MAATLC 182 Query: 632 GTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDI---LQENT 688 G+ Y+ PE + K D+WS+G I +QCL G+ PF S QD+ ++N Sbjct: 183 GSPMYMAPEVIM----SQHYDGKADLWSIGTIVYQCLTGKAPF-QASSPQDLRLFYEKNK 237 Query: 689 ILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL--LPHMRRS 741 L T + S+ + + L +DR D + + P+L P +R+S Sbjct: 238 TLVPT-----IPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKS 287 >gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] Length = 479 Score = 104 bits (259), Expect = 4e-22 Identities = 113/399 (28%), Positives = 175/399 (43%), Gaps = 40/399 (10%) Query: 326 VKQQEWVNQQREDIE--RQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAE--NDP 381 + ++ WV ++ E I+ R R L K + P P N +V + Sbjct: 6 IVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTE 65 Query: 382 FVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAE-IQAELERLERVRNLHIR-----EL 435 +PN + L E F + ++E E IQA +RL+R + ++ Sbjct: 66 RPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQI 125 Query: 436 KRINNEDNSQFKDH---PTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKS 492 I E+ H T+N+ + L LLG+G F +V + +Y A+KI L K Sbjct: 126 DNIGEEEMDASTTHHKRKTMND-FDYLKLLGKGTFGKVILVREKASGKYYAMKI--LKKE 182 Query: 493 WRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQ 552 K E H E R+ K HP + L Y D C V+EY G +L F+L + Sbjct: 183 VIIAKDEV--AHTLTESRVLKNTRHPFLTSL-KYSFQTKDRLCFVMEYVNGGELFFHLSR 239 Query: 553 HKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSK 612 ++ SE R +IV+AL YL+ K I++ DLK N++L G IKITDFGL K Sbjct: 240 ERVFSEDRTRFYGAEIVSALDYLHSGK--IVYRDLKLENLML---DKDGHIKITDFGLCK 294 Query: 613 IMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRK 672 G+ GT YL PE E VD W +GV+ ++ + GR Sbjct: 295 ------EGITDAATMKTFCGTPEYLAPEVL----EDNDYGRAVDWWGLGVVMYEMMCGRL 344 Query: 673 PFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFI 711 PF +NQ + + + ++ +++FP +SS+AK+ + Sbjct: 345 PF-YNQDHEKLFE---LILMEDIKFP--RTLSSDAKSLL 377 >gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] Length = 465 Score = 104 bits (259), Expect = 4e-22 Identities = 113/399 (28%), Positives = 175/399 (43%), Gaps = 40/399 (10%) Query: 326 VKQQEWVNQQREDIE--RQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAE--NDP 381 + ++ WV ++ E I+ R R L K + P P N +V + Sbjct: 6 IVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTE 65 Query: 382 FVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAE-IQAELERLERVRNLHIR-----EL 435 +PN + L E F + ++E E IQA +RL+R + ++ Sbjct: 66 RPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQI 125 Query: 436 KRINNEDNSQFKDH---PTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKS 492 I E+ H T+N+ + L LLG+G F +V + +Y A+KI L K Sbjct: 126 DNIGEEEMDASTTHHKRKTMND-FDYLKLLGKGTFGKVILVREKASGKYYAMKI--LKKE 182 Query: 493 WRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQ 552 K E H E R+ K HP + L Y D C V+EY G +L F+L + Sbjct: 183 VIIAKDEV--AHTLTESRVLKNTRHPFLTSL-KYSFQTKDRLCFVMEYVNGGELFFHLSR 239 Query: 553 HKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSK 612 ++ SE R +IV+AL YL+ K I++ DLK N++L G IKITDFGL K Sbjct: 240 ERVFSEDRTRFYGAEIVSALDYLHSGK--IVYRDLKLENLML---DKDGHIKITDFGLCK 294 Query: 613 IMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRK 672 G+ GT YL PE E VD W +GV+ ++ + GR Sbjct: 295 ------EGITDAATMKTFCGTPEYLAPEVL----EDNDYGRAVDWWGLGVVMYEMMCGRL 344 Query: 673 PFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFI 711 PF +NQ + + + ++ +++FP +SS+AK+ + Sbjct: 345 PF-YNQDHEKLFE---LILMEDIKFP--RTLSSDAKSLL 377 >gi|156105707 SNF related kinase [Homo sapiens] Length = 765 Score = 104 bits (259), Expect = 4e-22 Identities = 85/280 (30%), Positives = 137/280 (48%), Gaps = 27/280 (9%) Query: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 515 Y L LGRG F+ V A ++ AVK+ ++K+ D H +E R K + Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKV--IDKTKLDTLATG---HLFQEVRCMKLV 70 Query: 516 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDL-DFYLKQHKLMSEKEARSIVMQIVNALRY 574 HP IV+LY+ T + +LE +G D+ D+ +K + ++E A+ QIV+A+ Y Sbjct: 71 QHPNIVRLYEVIDTQTKLY-LILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 129 Query: 575 LNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTY 634 +++ ++H DLKP N++ + G +K+TDFG S G LT+ G+ Sbjct: 130 CHKLH--VVHRDLKPENVVFFEKQ--GLVKLTDFGFSNKFQ------PGKKLTT-SCGSL 178 Query: 635 WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE 694 Y PE ++G E + VD+WS+GVI F + G+ PF Q+ T+ + Sbjct: 179 AYSAPE-ILLGDEYD--APAVDIWSLGVILFMLVCGQPPF------QEANDSETLTMIMD 229 Query: 695 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734 ++ V VS E K I R L + R + ++ N P+L Sbjct: 230 CKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWL 269 >gi|156105705 SNF related kinase [Homo sapiens] Length = 765 Score = 104 bits (259), Expect = 4e-22 Identities = 85/280 (30%), Positives = 137/280 (48%), Gaps = 27/280 (9%) Query: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 515 Y L LGRG F+ V A ++ AVK+ ++K+ D H +E R K + Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKV--IDKTKLDTLATG---HLFQEVRCMKLV 70 Query: 516 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDL-DFYLKQHKLMSEKEARSIVMQIVNALRY 574 HP IV+LY+ T + +LE +G D+ D+ +K + ++E A+ QIV+A+ Y Sbjct: 71 QHPNIVRLYEVIDTQTKLY-LILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 129 Query: 575 LNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTY 634 +++ ++H DLKP N++ + G +K+TDFG S G LT+ G+ Sbjct: 130 CHKLH--VVHRDLKPENVVFFEKQ--GLVKLTDFGFSNKFQ------PGKKLTT-SCGSL 178 Query: 635 WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE 694 Y PE ++G E + VD+WS+GVI F + G+ PF Q+ T+ + Sbjct: 179 AYSAPE-ILLGDEYD--APAVDIWSLGVILFMLVCGQPPF------QEANDSETLTMIMD 229 Query: 695 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734 ++ V VS E K I R L + R + ++ N P+L Sbjct: 230 CKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWL 269 >gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d [Homo sapiens] Length = 713 Score = 103 bits (258), Expect = 5e-22 Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 29/280 (10%) Query: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 515 Y LL +G+G F++V A + R A+KI + + + RE RI K L Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPTSLQKLFREVRIMKIL 110 Query: 516 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 575 +HP IVKL++ + T ++EY G ++ YL H M EKEARS QIV+A++Y Sbjct: 111 NHPNIVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169 Query: 576 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 635 ++ + I+H DLK N+LL A IKI DFG S + + V G T G+ Sbjct: 170 HQKR--IVHRDLKAENLLL---DADMNIKIADFGFS-----NEFTVGGKLDTFCGSPP-- 217 Query: 636 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILKATE 694 Y PE F K +VDVWS+GVI + + G PF G N + L+E + Sbjct: 218 YAAPELFQGKKYD---GPEVDVWSLGVILYTLVSGSLPFDGQNLKE---LRERVLRGKYR 271 Query: 695 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734 + F +S++ + ++R L R + Q+ D ++ Sbjct: 272 IPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307 >gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b [Homo sapiens] Length = 744 Score = 103 bits (258), Expect = 5e-22 Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 29/280 (10%) Query: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 515 Y LL +G+G F++V A + R A+KI + + + RE RI K L Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPTSLQKLFREVRIMKIL 110 Query: 516 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 575 +HP IVKL++ + T ++EY G ++ YL H M EKEARS QIV+A++Y Sbjct: 111 NHPNIVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169 Query: 576 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 635 ++ + I+H DLK N+LL A IKI DFG S + + V G T G+ Sbjct: 170 HQKR--IVHRDLKAENLLL---DADMNIKIADFGFS-----NEFTVGGKLDTFCGSPP-- 217 Query: 636 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILKATE 694 Y PE F K +VDVWS+GVI + + G PF G N + L+E + Sbjct: 218 YAAPELFQGKKYD---GPEVDVWSLGVILYTLVSGSLPFDGQNLKE---LRERVLRGKYR 271 Query: 695 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734 + F +S++ + ++R L R + Q+ D ++ Sbjct: 272 IPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307 >gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a [Homo sapiens] Length = 753 Score = 103 bits (258), Expect = 5e-22 Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 29/280 (10%) Query: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 515 Y LL +G+G F++V A + R A+KI + + + RE RI K L Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPTSLQKLFREVRIMKIL 110 Query: 516 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 575 +HP IVKL++ + T ++EY G ++ YL H M EKEARS QIV+A++Y Sbjct: 111 NHPNIVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169 Query: 576 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 635 ++ + I+H DLK N+LL A IKI DFG S + + V G T G+ Sbjct: 170 HQKR--IVHRDLKAENLLL---DADMNIKIADFGFS-----NEFTVGGKLDTFCGSPP-- 217 Query: 636 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILKATE 694 Y PE F K +VDVWS+GVI + + G PF G N + L+E + Sbjct: 218 YAAPELFQGKKYD---GPEVDVWSLGVILYTLVSGSLPFDGQNLKE---LRERVLRGKYR 271 Query: 695 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734 + F +S++ + ++R L R + Q+ D ++ Sbjct: 272 IPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307 >gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c [Homo sapiens] Length = 729 Score = 103 bits (258), Expect = 5e-22 Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 29/280 (10%) Query: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 515 Y LL +G+G F++V A + R A+KI + + + RE RI K L Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPTSLQKLFREVRIMKIL 110 Query: 516 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 575 +HP IVKL++ + T ++EY G ++ YL H M EKEARS QIV+A++Y Sbjct: 111 NHPNIVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169 Query: 576 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 635 ++ + I+H DLK N+LL A IKI DFG S + + V G T G+ Sbjct: 170 HQKR--IVHRDLKAENLLL---DADMNIKIADFGFS-----NEFTVGGKLDTFCGSPP-- 217 Query: 636 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILKATE 694 Y PE F K +VDVWS+GVI + + G PF G N + L+E + Sbjct: 218 YAAPELFQGKKYD---GPEVDVWSLGVILYTLVSGSLPFDGQNLKE---LRERVLRGKYR 271 Query: 695 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734 + F +S++ + ++R L R + Q+ D ++ Sbjct: 272 IPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.314 0.131 0.379 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 31,790,861 Number of Sequences: 37866 Number of extensions: 1558415 Number of successful extensions: 10432 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 238 Number of HSP's successfully gapped in prelim test: 858 Number of HSP's that attempted gapping in prelim test: 7849 Number of HSP's gapped (non-prelim): 2285 length of query: 766 length of database: 18,247,518 effective HSP length: 110 effective length of query: 656 effective length of database: 14,082,258 effective search space: 9237961248 effective search space used: 9237961248 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.