Search of human proteins with 33636698

Search of human proteins with 33636698

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens]
         (766 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens]           1545   0.0  
gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens]          1450   0.0  
gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens]          1331   0.0  
gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens]           1030   0.0  
gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens]          1030   0.0  
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]               115   2e-25
gi|150456432 unc-51-like kinase 3 [Homo sapiens]                      115   2e-25
gi|93004081 polo-like kinase 2 [Homo sapiens]                         113   8e-25
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]              111   3e-24
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]               111   3e-24
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo...   110   4e-24
gi|62865643 aurora kinase C isoform 3 [Homo sapiens]                  109   8e-24
gi|62865641 aurora kinase C isoform 2 [Homo sapiens]                  109   8e-24
gi|62865639 aurora kinase C isoform 1 [Homo sapiens]                  109   8e-24
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s...   108   2e-23
gi|121114283 polo-like kinase 4 [Homo sapiens]                        107   3e-23
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s...   107   5e-23
gi|23308722 TTK protein kinase [Homo sapiens]                         106   7e-23
gi|217330634 serine/threonine kinase 36 [Homo sapiens]                105   1e-22
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   105   2e-22
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   105   2e-22
gi|4507831 Unc-51-like kinase 1 [Homo sapiens]                        104   4e-22
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       104   4e-22
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      104   4e-22
gi|156105707 SNF related kinase [Homo sapiens]                        104   4e-22
gi|156105705 SNF related kinase [Homo sapiens]                        104   4e-22
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor...   103   5e-22
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor...   103   5e-22
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor...   103   5e-22
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform...   103   5e-22

>gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens]
          Length = 766

 Score = 1545 bits (4001), Expect = 0.0
 Identities = 766/766 (100%), Positives = 766/766 (100%)

Query: 1   MSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQ 60
           MSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQ
Sbjct: 1   MSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQ 60

Query: 61  ELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESS 120
           ELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESS
Sbjct: 61  ELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESS 120

Query: 121 RGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTP 180
           RGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTP
Sbjct: 121 RGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTP 180

Query: 181 SSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRID 240
           SSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRID
Sbjct: 181 SSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRID 240

Query: 241 DLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRL 300
           DLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRL
Sbjct: 241 DLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRL 300

Query: 301 GHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAP 360
           GHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAP
Sbjct: 301 GHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAP 360

Query: 361 STNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAE 420
           STNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAE
Sbjct: 361 STNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAE 420

Query: 421 LERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQR 480
           LERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQR
Sbjct: 421 LERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQR 480

Query: 481 YAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEY 540
           YAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEY
Sbjct: 481 YAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEY 540

Query: 541 CEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTAC 600
           CEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTAC
Sbjct: 541 CEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTAC 600

Query: 601 GEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSV 660
           GEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSV
Sbjct: 601 GEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSV 660

Query: 661 GVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKE 720
           GVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKE
Sbjct: 661 GVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKE 720

Query: 721 DRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 766
           DRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY
Sbjct: 721 DRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 766


>gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens]
          Length = 718

 Score = 1450 bits (3754), Expect = 0.0
 Identities = 718/718 (100%), Positives = 718/718 (100%)

Query: 49  MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 108
           MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE
Sbjct: 1   MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 60

Query: 109 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 168
           SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI
Sbjct: 61  SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 120

Query: 169 RSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNK 228
           RSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNK
Sbjct: 121 RSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNK 180

Query: 229 IQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLS 288
           IQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLS
Sbjct: 181 IQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLS 240

Query: 289 SREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAK 348
           SREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAK
Sbjct: 241 SREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAK 300

Query: 349 RKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLG 408
           RKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLG
Sbjct: 301 RKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLG 360

Query: 409 HLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFS 468
           HLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFS
Sbjct: 361 HLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFS 420

Query: 469 EVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS 528
           EVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS
Sbjct: 421 EVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS 480

Query: 529 LDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLK 588
           LDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLK
Sbjct: 481 LDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLK 540

Query: 589 PGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEP 648
           PGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEP
Sbjct: 541 PGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEP 600

Query: 649 PKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAK 708
           PKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAK
Sbjct: 601 PKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAK 660

Query: 709 AFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 766
           AFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY
Sbjct: 661 AFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 718


>gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens]
          Length = 670

 Score = 1331 bits (3444), Expect = 0.0
 Identities = 656/657 (99%), Positives = 657/657 (100%)

Query: 110 ETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR 169
           +TPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR
Sbjct: 14  KTPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR 73

Query: 170 SPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKI 229
           SPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKI
Sbjct: 74  SPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKI 133

Query: 230 QDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS 289
           QDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS
Sbjct: 134 QDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS 193

Query: 290 REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKR 349
           REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKR
Sbjct: 194 REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKR 253

Query: 350 KPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGH 409
           KPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGH
Sbjct: 254 KPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGH 313

Query: 410 LKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSE 469
           LKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSE
Sbjct: 314 LKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSE 373

Query: 470 VYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL 529
           VYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL
Sbjct: 374 VYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL 433

Query: 530 DTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKP 589
           DTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKP
Sbjct: 434 DTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKP 493

Query: 590 GNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPP 649
           GNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPP
Sbjct: 494 GNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPP 553

Query: 650 KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA 709
           KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA
Sbjct: 554 KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA 613

Query: 710 FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 766
           FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY
Sbjct: 614 FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 670


>gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens]
          Length = 750

 Score = 1030 bits (2664), Expect = 0.0
 Identities = 551/773 (71%), Positives = 606/773 (78%), Gaps = 88/773 (11%)

Query: 49  MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 108
           M+ELHSLDPRRQELLEARFTGV              +K   N+ESSN S  S+GSLSDKE
Sbjct: 2   MEELHSLDPRRQELLEARFTGVGV------------SKGPLNSESSNQSLCSVGSLSDKE 49

Query: 109 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGN--GSSPVRG--- 163
            ETPEKKQ++  R RKRKAE   E+SQGK    RGHKISDYFE+ GG+  G+SP R    
Sbjct: 50  VETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFEFAGGSAPGTSPGRSVPP 106

Query: 164 -------------IPPAIRSPQ-----NSHSHSTPSSSVRP------------------- 186
                        +P  +  P      ++   +T   S  P                   
Sbjct: 107 VARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQ 166

Query: 187 --------------NSPSPTALAFGDHPIVQPKQLSFKIIQT--DLTMLKLAALESNKIQ 230
                         NSPS T     +H     KQ+S +  QT  DLT+ K++ALE++K  
Sbjct: 167 RGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNS 226

Query: 231 DLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSR 290
           DLEKKEGRIDDLLRANCDLRRQIDEQQK+LEKYKERLN+C++MSKKLLIEKS QEK++ R
Sbjct: 227 DLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACR 286

Query: 291 EKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRK 350
           +KSMQDRLRLGHFTTVRHGASFTEQWTDG+AFQNL+KQQE +N QRE+IERQRK+LAKRK
Sbjct: 287 DKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRK 346

Query: 351 PPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHL 410
           PP     QAP   +E KQRK+K  NGAEN+          LTLAEYHEQEEIFKLRLGHL
Sbjct: 347 PPAMG--QAPPATNEQKQRKSKT-NGAENET---------LTLAEYHEQEEIFKLRLGHL 394

Query: 411 KKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEV 470
           KKEEAEIQAELERLERVRNLHIRELKRI+NEDNSQFKDHPTLN+RYLLLHLLGRGGFSEV
Sbjct: 395 KKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEV 454

Query: 471 YKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD 530
           YKAFDL EQRY AVKIHQLNK+WRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD
Sbjct: 455 YKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD 514

Query: 531 TDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPG 590
           TD+FCTVLEYCEGNDLDFYLKQHKLMSEKEARSI+MQIVNAL+YLNEIKPPIIHYDLKPG
Sbjct: 515 TDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPG 574

Query: 591 NILLVDGTACGEIKITDFGLSKIMDDDSY-GVDGMDLTSQGAGTYWYLPPECFVVGKEPP 649
           NILLV+GTACGEIKITDFGLSKIMDDDSY  VDGM+LTSQGAGTYWYLPPECFVVGKEPP
Sbjct: 575 NILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPP 634

Query: 650 KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA 709
           KISNKVDVWSVGVIF+QCLYGRKPFGHNQSQQDILQENTILKATEVQFP KPVV+ EAKA
Sbjct: 635 KISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKA 694

Query: 710 FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSS 762
           FIRRCLAYRKEDR DV QLA DPYLLPH+R+S S+ +   AG   + T  +S+
Sbjct: 695 FIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSS--PAGAAIASTSGASN 745


>gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens]
          Length = 718

 Score = 1030 bits (2662), Expect = 0.0
 Identities = 544/744 (73%), Positives = 598/744 (80%), Gaps = 62/744 (8%)

Query: 49  MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 108
           M+ELHSLDPRRQELLEARFTGV              +K   N+ESSN S  S+GSLSDKE
Sbjct: 2   MEELHSLDPRRQELLEARFTGVGV------------SKGPLNSESSNQSLCSVGSLSDKE 49

Query: 109 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 168
            ETPEKKQ++  R RKRKAE   E+SQGK    RGHKISDYFE +      P+ G+  + 
Sbjct: 50  VETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFERRV---EQPLYGLDGSA 103

Query: 169 RSPQNSHSHSTPSS---------------------------SVRPNSPSPTALAFGDHPI 201
                    + P+                            S + NSPS T     +H  
Sbjct: 104 AKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSC 163

Query: 202 VQPKQLSFKIIQT--DLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKL 259
              KQ+S +  QT  DLT+ K++ALE++K  DLEKKEGRIDDLLRANCDLRRQIDEQQK+
Sbjct: 164 SSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKM 223

Query: 260 LEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDG 319
           LEKYKERLN+C++MSKKLLIEKS QEK++ R+KSMQDRLRLGHFTTVRHGASFTEQWTDG
Sbjct: 224 LEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDG 283

Query: 320 FAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAEN 379
           +AFQNL+KQQE +N QRE+IERQRK+LAKRKPP     QAP   +E KQRK+K  NGAEN
Sbjct: 284 YAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG--QAPPATNEQKQRKSKT-NGAEN 340

Query: 380 DPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIN 439
           +          LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRI+
Sbjct: 341 ET---------LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIH 391

Query: 440 NEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE 499
           NEDNSQFKDHPTLN+RYLLLHLLGRGGFSEVYKAFDL EQRY AVKIHQLNK+WRDEKKE
Sbjct: 392 NEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE 451

Query: 500 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEK 559
           NYHKHACREYRIHKELDHPRIVKLYDYFSLDTD+FCTVLEYCEGNDLDFYLKQHKLMSEK
Sbjct: 452 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEK 511

Query: 560 EARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSY 619
           EARSI+MQIVNAL+YLNEIKPPIIHYDLKPGNILLV+GTACGEIKITDFGLSKIMDDDSY
Sbjct: 512 EARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSY 571

Query: 620 -GVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQ 678
             VDGM+LTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF+QCLYGRKPFGHNQ
Sbjct: 572 NSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQ 631

Query: 679 SQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHM 738
           SQQDILQENTILKATEVQFP KPVV+ EAKAFIRRCLAYRKEDR DV QLA DPYLLPH+
Sbjct: 632 SQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 691

Query: 739 RRSNSSGNLHMAGLTASPTPPSSS 762
           R+S S+ +   AG   + T  +S+
Sbjct: 692 RKSVSTSS--PAGAAIASTSGASN 713


>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
          Length = 661

 Score =  115 bits (288), Expect = 2e-25
 Identities = 87/279 (31%), Positives = 134/279 (48%), Gaps = 27/279 (9%)

Query: 452 LNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRI 511
           L  RY L   LG+G + +V +A + +  R  A+K  + +K     K E    H  RE  I
Sbjct: 51  LKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKI----KDEQDMVHIRREIEI 106

Query: 512 HKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNA 571
              L+HP I+ +Y+ F  + D    ++EY    +L  Y+ + + +SE+E R    QIV+A
Sbjct: 107 MSSLNHPHIISIYEVFE-NKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSA 165

Query: 572 LRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGA 631
           + Y +  K  ++H DLK  NILL D      IKI DFGLS +   D +            
Sbjct: 166 VHYCH--KNGVVHRDLKLENILLDDNC---NIKIADFGLSNLYQKDKF-------LQTFC 213

Query: 632 GTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILK 691
           G+  Y  PE  V G+  P    +VD W++GV+ +  +YG  PF     +  I Q    + 
Sbjct: 214 GSPLYASPE-IVNGR--PYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQ----IS 266

Query: 692 ATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLAN 730
           + E + P +P   S+A+  IR  L    + R  +  +AN
Sbjct: 267 SGEYREPTQP---SDARGLIRWMLMVNPDRRATIEDIAN 302


>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
          Length = 472

 Score =  115 bits (287), Expect = 2e-25
 Identities = 86/299 (28%), Positives = 139/299 (46%), Gaps = 27/299 (9%)

Query: 450 PTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREY 509
           P   + ++L   LG G ++ VYKA+   + R          KS      EN       E 
Sbjct: 8   PPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENL----LTEI 63

Query: 510 RIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIV 569
            I K + HP IV+L D F  D+D    ++E+C G DL  ++   +++ EK AR  + Q+ 
Sbjct: 64  EILKGIRHPHIVQLKD-FQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLA 122

Query: 570 NALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMD--DDSYGVDGMDLT 627
           +AL++L+E    I H DLKP NILL        +K+ DFG ++ M   D+ + + G  L 
Sbjct: 123 SALQFLHERN--ISHLDLKPQNILL-SSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL- 178

Query: 628 SQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQEN 687
                   Y+ PE         +   +VD+WS+GVI ++ L+G+ PF      +    E 
Sbjct: 179 --------YMAPEMVC----QRQYDARVDLWSMGVILYEALFGQPPFASRSFSE---LEE 223

Query: 688 TILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL-LPHMRRSNSSG 745
            I     ++ P++P++S + +  ++R L      R         P++ L HM    S G
Sbjct: 224 KIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLG 282


>gi|93004081 polo-like kinase 2 [Homo sapiens]
          Length = 685

 Score =  113 bits (282), Expect = 8e-25
 Identities = 86/291 (29%), Positives = 139/291 (47%), Gaps = 36/291 (12%)

Query: 450 PTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREY 509
           PT  +RY    +LG+GGF++ Y+  DL   +  A KI   ++  +  ++E   K    E 
Sbjct: 76  PTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDK----EI 131

Query: 510 RIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIV 569
            +H+ L H  +V+ Y YF  D +    +LEYC    +   LK  K+++E E R  + QIV
Sbjct: 132 ELHRILHHKHVVQFYHYFE-DKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIV 190

Query: 570 NALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQ 629
           + L+YL+E    I+H DLK GN  + +     E+K+ DFGL+  ++   +    +     
Sbjct: 191 SGLKYLHE--QEILHRDLKLGNFFINEAM---ELKVGDFGLAARLEPLEHRRRTI----- 240

Query: 630 GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTI 689
             GT  YL PE  V+ K+     +  D+W++G + +  L GR PF           E T 
Sbjct: 241 -CGTPNYLSPE--VLNKQGHGCES--DIWALGCVMYTMLLGRPPF-----------ETTN 284

Query: 690 LKAT-----EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLL 735
           LK T     E ++ +   + + AK  I   L+   EDR  +  +    + L
Sbjct: 285 LKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFL 335


>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
          Length = 586

 Score =  111 bits (277), Expect = 3e-24
 Identities = 91/284 (32%), Positives = 137/284 (48%), Gaps = 14/284 (4%)

Query: 452 LNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE-NYHKHACREYR 510
           L + Y++   LG G   EV  AF+    +  A+KI    K      +E +   +   E  
Sbjct: 259 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 318

Query: 511 IHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVN 570
           I K+L+HP I+K+ ++F  D + +  VLE  EG +L   +  +K + E   +    Q++ 
Sbjct: 319 ILKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 376

Query: 571 ALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQG 630
           A++YL+E    IIH DLKP N+LL        IKITDFG SKI+ + S       L    
Sbjct: 377 AVQYLHE--NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS-------LMRTL 427

Query: 631 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTIL 690
            GT  YL PE  +V       +  VD WS+GVI F CL G  PF  +++Q  +  + T  
Sbjct: 428 CGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSG 486

Query: 691 KATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734
           K   +   V   VS +A   +++ L    + RF   +    P+L
Sbjct: 487 KYNFIP-EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 529


>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
          Length = 543

 Score =  111 bits (277), Expect = 3e-24
 Identities = 91/284 (32%), Positives = 137/284 (48%), Gaps = 14/284 (4%)

Query: 452 LNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE-NYHKHACREYR 510
           L + Y++   LG G   EV  AF+    +  A+KI    K      +E +   +   E  
Sbjct: 216 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 275

Query: 511 IHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVN 570
           I K+L+HP I+K+ ++F  D + +  VLE  EG +L   +  +K + E   +    Q++ 
Sbjct: 276 ILKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 333

Query: 571 ALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQG 630
           A++YL+E    IIH DLKP N+LL        IKITDFG SKI+ + S       L    
Sbjct: 334 AVQYLHE--NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS-------LMRTL 384

Query: 631 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTIL 690
            GT  YL PE  +V       +  VD WS+GVI F CL G  PF  +++Q  +  + T  
Sbjct: 385 CGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSG 443

Query: 691 KATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734
           K   +   V   VS +A   +++ L    + RF   +    P+L
Sbjct: 444 KYNFIP-EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486


>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
           sapiens]
          Length = 476

 Score =  110 bits (276), Expect = 4e-24
 Identities = 86/299 (28%), Positives = 145/299 (48%), Gaps = 25/299 (8%)

Query: 437 RINNEDNSQFKDHPT-LNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRD 495
           R   +D S +K   T + + ++ + +LG G FSEV+        +  A+K  + + ++RD
Sbjct: 3   RKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD 62

Query: 496 EKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKL 555
              EN       E  + K++ H  IV L D +   T  +  V++   G +L   + +  +
Sbjct: 63  SSLEN-------EIAVLKKIKHENIVTLEDIYE-STTHYYLVMQLVSGGELFDRILERGV 114

Query: 556 MSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMD 615
            +EK+A  ++ Q+++A++YL+E    I+H DLKP N+L +      +I ITDFGLSK+  
Sbjct: 115 YTEKDASLVIQQVLSAVKYLHE--NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQ 172

Query: 616 DDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFG 675
           +         + S   GT  Y+ PE  V+ ++P   S  VD WS+GVI +  L G  PF 
Sbjct: 173 N--------GIMSTACGTPGYVAPE--VLAQKP--YSKAVDCWSIGVITYILLCGYPPF- 219

Query: 676 HNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734
             +  +  L E       E + P    +S  AK FI   L     +R+   +  + P++
Sbjct: 220 -YEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277


>gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
          Length = 275

 Score =  109 bits (273), Expect = 8e-24
 Identities = 89/282 (31%), Positives = 138/282 (48%), Gaps = 34/282 (12%)

Query: 462 LGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIV 521
           LG+G F  VY A    ++ +  V +  L KS    +KE       RE  I   L HP I+
Sbjct: 15  LGKGKFGNVYLA--RLKESHFIVALKVLFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 70

Query: 522 KLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPP 581
           +LY+YF  D      +LEY    +L   L++ + + E+   +I+ ++ +AL Y ++ K  
Sbjct: 71  RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 127

Query: 582 IIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPEC 641
           +IH D+KP N+LL      GE+KI DFG S  +   S     M       GT  YLPPE 
Sbjct: 128 VIHRDIKPENLLL---GFRGEVKIADFGWS--VHTPSLRRKTM------CGTLDYLPPEM 176

Query: 642 FVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF---GHNQSQQDILQENTILKATEVQFP 698
                E      KVD+W +GV+ ++ L G  PF    H+++ + IL+        +V+FP
Sbjct: 177 I----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRFP 225

Query: 699 VKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRR 740
           +   +   A+  I R L Y+  +R  + Q+   P++  H RR
Sbjct: 226 LSMPLG--ARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 265


>gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
          Length = 290

 Score =  109 bits (273), Expect = 8e-24
 Identities = 89/282 (31%), Positives = 138/282 (48%), Gaps = 34/282 (12%)

Query: 462 LGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIV 521
           LG+G F  VY A    ++ +  V +  L KS    +KE       RE  I   L HP I+
Sbjct: 30  LGKGKFGNVYLA--RLKESHFIVALKVLFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 85

Query: 522 KLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPP 581
           +LY+YF  D      +LEY    +L   L++ + + E+   +I+ ++ +AL Y ++ K  
Sbjct: 86  RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 142

Query: 582 IIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPEC 641
           +IH D+KP N+LL      GE+KI DFG S  +   S     M       GT  YLPPE 
Sbjct: 143 VIHRDIKPENLLL---GFRGEVKIADFGWS--VHTPSLRRKTM------CGTLDYLPPEM 191

Query: 642 FVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF---GHNQSQQDILQENTILKATEVQFP 698
                E      KVD+W +GV+ ++ L G  PF    H+++ + IL+        +V+FP
Sbjct: 192 I----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRFP 240

Query: 699 VKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRR 740
           +   +   A+  I R L Y+  +R  + Q+   P++  H RR
Sbjct: 241 LSMPLG--ARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 280


>gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
          Length = 309

 Score =  109 bits (273), Expect = 8e-24
 Identities = 89/282 (31%), Positives = 138/282 (48%), Gaps = 34/282 (12%)

Query: 462 LGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIV 521
           LG+G F  VY A    ++ +  V +  L KS    +KE       RE  I   L HP I+
Sbjct: 49  LGKGKFGNVYLA--RLKESHFIVALKVLFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 104

Query: 522 KLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPP 581
           +LY+YF  D      +LEY    +L   L++ + + E+   +I+ ++ +AL Y ++ K  
Sbjct: 105 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 161

Query: 582 IIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPEC 641
           +IH D+KP N+LL      GE+KI DFG S  +   S     M       GT  YLPPE 
Sbjct: 162 VIHRDIKPENLLL---GFRGEVKIADFGWS--VHTPSLRRKTM------CGTLDYLPPEM 210

Query: 642 FVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF---GHNQSQQDILQENTILKATEVQFP 698
                E      KVD+W +GV+ ++ L G  PF    H+++ + IL+        +V+FP
Sbjct: 211 I----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRFP 259

Query: 699 VKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRR 740
           +   +   A+  I R L Y+  +R  + Q+   P++  H RR
Sbjct: 260 LSMPLG--ARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 299


>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
           sapiens]
          Length = 370

 Score =  108 bits (270), Expect = 2e-23
 Identities = 87/295 (29%), Positives = 145/295 (49%), Gaps = 26/295 (8%)

Query: 442 DNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVK-IHQLNKSWRDEKKEN 500
           +  ++K    + + Y    +LG G FSEV  A D   Q+  A+K I +     ++   EN
Sbjct: 6   EGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMEN 65

Query: 501 YHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKE 560
                  E  +  ++ HP IV L D +      +  +++   G +L   + +    +E++
Sbjct: 66  -------EIAVLHKIKHPNIVALDDIYESGGHLYL-IMQLVSGGELFDRIVEKGFYTERD 117

Query: 561 ARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYG 620
           A  ++ Q+++A++YL+++   I+H DLKP N+L        +I I+DFGLSK+ D  S  
Sbjct: 118 ASRLIFQVLDAVKYLHDLG--IVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGS-- 173

Query: 621 VDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQ 680
                + S   GT  Y+ PE  V+ ++P   S  VD WS+GVI +  L G  PF ++++ 
Sbjct: 174 -----VLSTACGTPGYVAPE--VLAQKP--YSKAVDCWSIGVIAYILLCGYPPF-YDEND 223

Query: 681 QDILQENTILKAT-EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734
             + ++  ILKA  E   P    +S  AK FIR  +    E RF   Q    P++
Sbjct: 224 AKLFEQ--ILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276


>gi|121114283 polo-like kinase 4 [Homo sapiens]
          Length = 970

 Score =  107 bits (268), Expect = 3e-23
 Identities = 86/285 (30%), Positives = 138/285 (48%), Gaps = 33/285 (11%)

Query: 454 ERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHK 513
           E + + +LLG+G F+ VY+A  ++     A+K+      +    K    +    E +IH 
Sbjct: 10  EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMY----KAGMVQRVQNEVKIHC 65

Query: 514 ELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQH-KLMSEKEARSIVMQIVNAL 572
           +L HP I++LY+YF  D++    VLE C   +++ YLK   K  SE EAR  + QI+  +
Sbjct: 66  QLKHPSILELYNYFE-DSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGM 124

Query: 573 RYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLS---KIMDDDSYGVDGMDLTSQ 629
            YL+     I+H DL   N+LL   T    IKI DFGL+   K+  +  Y +        
Sbjct: 125 LYLH--SHGILHRDLTLSNLLL---TRNMNIKIADFGLATQLKMPHEKHYTL-------- 171

Query: 630 GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTI 689
             GT  Y+ PE  +  +    + +  DVWS+G +F+  L GR PF  +        +NT+
Sbjct: 172 -CGTPNYISPE--IATRSAHGLES--DVWSLGCMFYTLLIGRPPFDTD------TVKNTL 220

Query: 690 LKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734
            K     + +   +S EAK  I + L     DR  +  + + P++
Sbjct: 221 NKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM 265


>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
           sapiens]
          Length = 688

 Score =  107 bits (266), Expect = 5e-23
 Identities = 93/283 (32%), Positives = 136/283 (48%), Gaps = 35/283 (12%)

Query: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKI---HQLNKSWRDEKKENYHKHACREYRIH 512
           Y LL  +G+G F++V  A  +   R  A+KI    QLN S   +          RE RI 
Sbjct: 59  YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQK--------LFREVRIM 110

Query: 513 KELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNAL 572
           K L+HP IVKL++    +  T   V+EY    ++  YL  H  M EKEAR+   QIV+A+
Sbjct: 111 KGLNHPNIVKLFEVIETEK-TLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAV 169

Query: 573 RYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAG 632
            Y ++    I+H DLK  N+LL    A   IKI DFG S   ++ + G           G
Sbjct: 170 HYCHQ--KNIVHRDLKAENLLL---DAEANIKIADFGFS---NEFTLG----SKLDTFCG 217

Query: 633 TYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILK 691
           +  Y  PE F   K       +VD+WS+GVI +  + G  PF GHN  +   L+E  +  
Sbjct: 218 SPPYAAPELFQGKKYD---GPEVDIWSLGVILYTLVSGSLPFDGHNLKE---LRERVLRG 271

Query: 692 ATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734
              V F     +S++ ++ +RR L      R  + Q+  D ++
Sbjct: 272 KYRVPF----YMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 310


>gi|23308722 TTK protein kinase [Homo sapiens]
          Length = 857

 Score =  106 bits (265), Expect = 7e-23
 Identities = 84/291 (28%), Positives = 143/291 (49%), Gaps = 36/291 (12%)

Query: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 515
           Y +L  +G GG S+V++  +  +Q YA +K   L ++  ++  ++Y        ++ +  
Sbjct: 525 YSILKQIGSGGSSKVFQVLNEKKQIYA-IKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 582

Query: 516 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 575
           D  +I++LYDY    TD +  ++  C   DL+ +LK+ K +   E +S    ++ A+  +
Sbjct: 583 D--KIIRLYDYEI--TDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 638

Query: 576 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 635
           ++    I+H DLKP N L+VDG     +K+ DFG++  M  D+  V    +     GT  
Sbjct: 639 HQ--HGIVHSDLKPANFLIVDGM----LKLIDFGIANQMQPDTTSV----VKDSQVGTVN 688

Query: 636 YLPPECFVV-------GKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENT 688
           Y+PPE           GK   KIS K DVWS+G I +   YG+ PF      Q I+ + +
Sbjct: 689 YMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQIS 742

Query: 689 ILKAT-----EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734
            L A      E++FP  P    + +  ++ CL    + R  + +L   PY+
Sbjct: 743 KLHAIIDPNHEIEFPDIP--EKDLQDVLKCCLKRDPKQRISIPELLAHPYV 791


>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
          Length = 1315

 Score =  105 bits (263), Expect = 1e-22
 Identities = 93/311 (29%), Positives = 145/311 (46%), Gaps = 28/311 (9%)

Query: 454 ERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHK 513
           E+Y +L ++G G F  VYK    Y  +  A+K   + K  R EK+    ++  RE  I +
Sbjct: 2   EKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKF--IPKLGRSEKE---LRNLQREIEIMR 56

Query: 514 ELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALR 573
            L HP IV + D F  D +    V +Y EG +L   L+    + E + ++I  Q+V+AL 
Sbjct: 57  GLRHPNIVHMLDSFETDKEV-VVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALY 114

Query: 574 YLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGT 633
           YL+  +  I+H D+KP NILL  G   G IK+ DFG ++ M  ++     M LTS   GT
Sbjct: 115 YLHSHR--ILHRDMKPQNILLAKG---GGIKLCDFGFARAMSTNT-----MVLTSI-KGT 163

Query: 634 YWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKAT 693
             Y+ PE  +V + P    +  D+WSVG I ++   G  PF        I Q  +++   
Sbjct: 164 PLYMSPE--LVEERP--YDHTADLWSVGCILYELAVGTPPF----YATSIFQLVSLILKD 215

Query: 694 EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLT 753
            V++P    +S   K F++  L      R     L   P++  H+          +    
Sbjct: 216 PVRWP--STISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPF 273

Query: 754 ASPTPPSSSII 764
            S  PP   ++
Sbjct: 274 TSRLPPELQVL 284


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  105 bits (261), Expect = 2e-22
 Identities = 88/279 (31%), Positives = 139/279 (49%), Gaps = 29/279 (10%)

Query: 459 LHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHP 518
           L ++G+G F +V  A    + ++ AVK+  L K     +KE  H  A R   + K + HP
Sbjct: 165 LKVIGKGSFGKVLLAKRKLDGKFYAVKV--LQKKIVLNRKEQKHIMAERNVLL-KNVKHP 221

Query: 519 RIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEI 578
            +V L+  F   T+    VL++  G +L F+L++ +   E  AR    +I +AL YL+ I
Sbjct: 222 FLVGLHYSFQT-TEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280

Query: 579 KPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLP 638
           K  I++ DLKP NILL    + G + +TDFGL K       G+   D T+   GT  YL 
Sbjct: 281 K--IVYRDLKPENILL---DSVGHVVLTDFGLCK------EGIAISDTTTTFCGTPEYLA 329

Query: 639 PECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFP 698
           PE  V+ K+P    N VD W +G + ++ LYG  PF      +  + +N + K       
Sbjct: 330 PE--VIRKQP--YDNTVDWWCLGAVLYEMLYGLPPFYCRDVAE--MYDNILHK----PLS 379

Query: 699 VKPVVSSEAKAFIRRCLAYRKEDRF----DVHQLANDPY 733
           ++P VS  A + +   L   +++R     D  ++ N P+
Sbjct: 380 LRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPF 418


>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  105 bits (261), Expect = 2e-22
 Identities = 88/279 (31%), Positives = 139/279 (49%), Gaps = 29/279 (10%)

Query: 459 LHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHP 518
           L ++G+G F +V  A    + ++ AVK+  L K     +KE  H  A R   + K + HP
Sbjct: 165 LKVIGKGSFGKVLLAKRKLDGKFYAVKV--LQKKIVLNRKEQKHIMAERNVLL-KNVKHP 221

Query: 519 RIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEI 578
            +V L+  F   T+    VL++  G +L F+L++ +   E  AR    +I +AL YL+ I
Sbjct: 222 FLVGLHYSFQT-TEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280

Query: 579 KPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLP 638
           K  I++ DLKP NILL    + G + +TDFGL K       G+   D T+   GT  YL 
Sbjct: 281 K--IVYRDLKPENILL---DSVGHVVLTDFGLCK------EGIAISDTTTTFCGTPEYLA 329

Query: 639 PECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFP 698
           PE  V+ K+P    N VD W +G + ++ LYG  PF      +  + +N + K       
Sbjct: 330 PE--VIRKQP--YDNTVDWWCLGAVLYEMLYGLPPFYCRDVAE--MYDNILHK----PLS 379

Query: 699 VKPVVSSEAKAFIRRCLAYRKEDRF----DVHQLANDPY 733
           ++P VS  A + +   L   +++R     D  ++ N P+
Sbjct: 380 LRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPF 418


>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
          Length = 1050

 Score =  104 bits (259), Expect = 4e-22
 Identities = 87/295 (29%), Positives = 133/295 (45%), Gaps = 42/295 (14%)

Query: 461 LLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHAC---REYRIHKELDH 517
           L+G G F+ V+K     +        H L  + +   K+N  K      +E +I KEL H
Sbjct: 21  LIGHGAFAVVFKGRHREK--------HDLEVAVKCINKKNLAKSQTLLGKEIKILKELKH 72

Query: 518 PRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNE 577
             IV LYD+  +    +  V+EYC G DL  YL   + +SE   R  + QI  A+R L+ 
Sbjct: 73  ENIVALYDFQEMANSVYL-VMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLH- 130

Query: 578 IKPPIIHYDLKPGNILLVDGTA------CGEIKITDFGLSKIMDDDSYGVDGMDLTSQGA 631
               IIH DLKP NILL +            +KI DFG ++ +  +        + +   
Sbjct: 131 -SKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNM-------MAATLC 182

Query: 632 GTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDI---LQENT 688
           G+  Y+ PE  +          K D+WS+G I +QCL G+ PF    S QD+    ++N 
Sbjct: 183 GSPMYMAPEVIM----SQHYDGKADLWSIGTIVYQCLTGKAPF-QASSPQDLRLFYEKNK 237

Query: 689 ILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL--LPHMRRS 741
            L  T     +    S+  +  +   L    +DR D  +  + P+L   P +R+S
Sbjct: 238 TLVPT-----IPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKS 287


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  104 bits (259), Expect = 4e-22
 Identities = 113/399 (28%), Positives = 175/399 (43%), Gaps = 40/399 (10%)

Query: 326 VKQQEWVNQQREDIE--RQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAE--NDP 381
           + ++ WV ++ E I+  R R  L K         + P     P    N +V   +     
Sbjct: 6   IVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTE 65

Query: 382 FVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAE-IQAELERLERVRNLHIR-----EL 435
             +PN   +  L      E  F +     ++E  E IQA  +RL+R     +      ++
Sbjct: 66  RPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQI 125

Query: 436 KRINNEDNSQFKDH---PTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKS 492
             I  E+      H    T+N+ +  L LLG+G F +V    +    +Y A+KI  L K 
Sbjct: 126 DNIGEEEMDASTTHHKRKTMND-FDYLKLLGKGTFGKVILVREKASGKYYAMKI--LKKE 182

Query: 493 WRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQ 552
               K E    H   E R+ K   HP +  L  Y     D  C V+EY  G +L F+L +
Sbjct: 183 VIIAKDEV--AHTLTESRVLKNTRHPFLTSL-KYSFQTKDRLCFVMEYVNGGELFFHLSR 239

Query: 553 HKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSK 612
            ++ SE   R    +IV+AL YL+  K  I++ DLK  N++L      G IKITDFGL K
Sbjct: 240 ERVFSEDRTRFYGAEIVSALDYLHSGK--IVYRDLKLENLML---DKDGHIKITDFGLCK 294

Query: 613 IMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRK 672
                  G+          GT  YL PE      E       VD W +GV+ ++ + GR 
Sbjct: 295 ------EGITDAATMKTFCGTPEYLAPEVL----EDNDYGRAVDWWGLGVVMYEMMCGRL 344

Query: 673 PFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFI 711
           PF +NQ  + + +   ++   +++FP    +SS+AK+ +
Sbjct: 345 PF-YNQDHEKLFE---LILMEDIKFP--RTLSSDAKSLL 377


>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  104 bits (259), Expect = 4e-22
 Identities = 113/399 (28%), Positives = 175/399 (43%), Gaps = 40/399 (10%)

Query: 326 VKQQEWVNQQREDIE--RQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAE--NDP 381
           + ++ WV ++ E I+  R R  L K         + P     P    N +V   +     
Sbjct: 6   IVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTE 65

Query: 382 FVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAE-IQAELERLERVRNLHIR-----EL 435
             +PN   +  L      E  F +     ++E  E IQA  +RL+R     +      ++
Sbjct: 66  RPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQI 125

Query: 436 KRINNEDNSQFKDH---PTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKS 492
             I  E+      H    T+N+ +  L LLG+G F +V    +    +Y A+KI  L K 
Sbjct: 126 DNIGEEEMDASTTHHKRKTMND-FDYLKLLGKGTFGKVILVREKASGKYYAMKI--LKKE 182

Query: 493 WRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQ 552
               K E    H   E R+ K   HP +  L  Y     D  C V+EY  G +L F+L +
Sbjct: 183 VIIAKDEV--AHTLTESRVLKNTRHPFLTSL-KYSFQTKDRLCFVMEYVNGGELFFHLSR 239

Query: 553 HKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSK 612
            ++ SE   R    +IV+AL YL+  K  I++ DLK  N++L      G IKITDFGL K
Sbjct: 240 ERVFSEDRTRFYGAEIVSALDYLHSGK--IVYRDLKLENLML---DKDGHIKITDFGLCK 294

Query: 613 IMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRK 672
                  G+          GT  YL PE      E       VD W +GV+ ++ + GR 
Sbjct: 295 ------EGITDAATMKTFCGTPEYLAPEVL----EDNDYGRAVDWWGLGVVMYEMMCGRL 344

Query: 673 PFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFI 711
           PF +NQ  + + +   ++   +++FP    +SS+AK+ +
Sbjct: 345 PF-YNQDHEKLFE---LILMEDIKFP--RTLSSDAKSLL 377


>gi|156105707 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  104 bits (259), Expect = 4e-22
 Identities = 85/280 (30%), Positives = 137/280 (48%), Gaps = 27/280 (9%)

Query: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 515
           Y L   LGRG F+ V  A  ++     AVK+  ++K+  D        H  +E R  K +
Sbjct: 16  YDLDKTLGRGHFAVVKLARHVFTGEKVAVKV--IDKTKLDTLATG---HLFQEVRCMKLV 70

Query: 516 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDL-DFYLKQHKLMSEKEARSIVMQIVNALRY 574
            HP IV+LY+     T  +  +LE  +G D+ D+ +K  + ++E  A+    QIV+A+ Y
Sbjct: 71  QHPNIVRLYEVIDTQTKLY-LILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 129

Query: 575 LNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTY 634
            +++   ++H DLKP N++  +    G +K+TDFG S           G  LT+   G+ 
Sbjct: 130 CHKLH--VVHRDLKPENVVFFEKQ--GLVKLTDFGFSNKFQ------PGKKLTT-SCGSL 178

Query: 635 WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE 694
            Y  PE  ++G E    +  VD+WS+GVI F  + G+ PF      Q+     T+    +
Sbjct: 179 AYSAPE-ILLGDEYD--APAVDIWSLGVILFMLVCGQPPF------QEANDSETLTMIMD 229

Query: 695 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734
            ++ V   VS E K  I R L    + R  + ++ N P+L
Sbjct: 230 CKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWL 269


>gi|156105705 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  104 bits (259), Expect = 4e-22
 Identities = 85/280 (30%), Positives = 137/280 (48%), Gaps = 27/280 (9%)

Query: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 515
           Y L   LGRG F+ V  A  ++     AVK+  ++K+  D        H  +E R  K +
Sbjct: 16  YDLDKTLGRGHFAVVKLARHVFTGEKVAVKV--IDKTKLDTLATG---HLFQEVRCMKLV 70

Query: 516 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDL-DFYLKQHKLMSEKEARSIVMQIVNALRY 574
            HP IV+LY+     T  +  +LE  +G D+ D+ +K  + ++E  A+    QIV+A+ Y
Sbjct: 71  QHPNIVRLYEVIDTQTKLY-LILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 129

Query: 575 LNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTY 634
            +++   ++H DLKP N++  +    G +K+TDFG S           G  LT+   G+ 
Sbjct: 130 CHKLH--VVHRDLKPENVVFFEKQ--GLVKLTDFGFSNKFQ------PGKKLTT-SCGSL 178

Query: 635 WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE 694
            Y  PE  ++G E    +  VD+WS+GVI F  + G+ PF      Q+     T+    +
Sbjct: 179 AYSAPE-ILLGDEYD--APAVDIWSLGVILFMLVCGQPPF------QEANDSETLTMIMD 229

Query: 695 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734
            ++ V   VS E K  I R L    + R  + ++ N P+L
Sbjct: 230 CKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWL 269


>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
           [Homo sapiens]
          Length = 713

 Score =  103 bits (258), Expect = 5e-22
 Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 29/280 (10%)

Query: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 515
           Y LL  +G+G F++V  A  +   R  A+KI       + +      +   RE RI K L
Sbjct: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPTSLQKLFREVRIMKIL 110

Query: 516 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 575
           +HP IVKL++    +  T   ++EY  G ++  YL  H  M EKEARS   QIV+A++Y 
Sbjct: 111 NHPNIVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169

Query: 576 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 635
           ++ +  I+H DLK  N+LL    A   IKI DFG S     + + V G   T  G+    
Sbjct: 170 HQKR--IVHRDLKAENLLL---DADMNIKIADFGFS-----NEFTVGGKLDTFCGSPP-- 217

Query: 636 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILKATE 694
           Y  PE F   K       +VDVWS+GVI +  + G  PF G N  +   L+E  +     
Sbjct: 218 YAAPELFQGKKYD---GPEVDVWSLGVILYTLVSGSLPFDGQNLKE---LRERVLRGKYR 271

Query: 695 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734
           + F     +S++ +  ++R L      R  + Q+  D ++
Sbjct: 272 IPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307


>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
           [Homo sapiens]
          Length = 744

 Score =  103 bits (258), Expect = 5e-22
 Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 29/280 (10%)

Query: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 515
           Y LL  +G+G F++V  A  +   R  A+KI       + +      +   RE RI K L
Sbjct: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPTSLQKLFREVRIMKIL 110

Query: 516 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 575
           +HP IVKL++    +  T   ++EY  G ++  YL  H  M EKEARS   QIV+A++Y 
Sbjct: 111 NHPNIVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169

Query: 576 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 635
           ++ +  I+H DLK  N+LL    A   IKI DFG S     + + V G   T  G+    
Sbjct: 170 HQKR--IVHRDLKAENLLL---DADMNIKIADFGFS-----NEFTVGGKLDTFCGSPP-- 217

Query: 636 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILKATE 694
           Y  PE F   K       +VDVWS+GVI +  + G  PF G N  +   L+E  +     
Sbjct: 218 YAAPELFQGKKYD---GPEVDVWSLGVILYTLVSGSLPFDGQNLKE---LRERVLRGKYR 271

Query: 695 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734
           + F     +S++ +  ++R L      R  + Q+  D ++
Sbjct: 272 IPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307


>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
           [Homo sapiens]
          Length = 753

 Score =  103 bits (258), Expect = 5e-22
 Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 29/280 (10%)

Query: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 515
           Y LL  +G+G F++V  A  +   R  A+KI       + +      +   RE RI K L
Sbjct: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPTSLQKLFREVRIMKIL 110

Query: 516 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 575
           +HP IVKL++    +  T   ++EY  G ++  YL  H  M EKEARS   QIV+A++Y 
Sbjct: 111 NHPNIVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169

Query: 576 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 635
           ++ +  I+H DLK  N+LL    A   IKI DFG S     + + V G   T  G+    
Sbjct: 170 HQKR--IVHRDLKAENLLL---DADMNIKIADFGFS-----NEFTVGGKLDTFCGSPP-- 217

Query: 636 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILKATE 694
           Y  PE F   K       +VDVWS+GVI +  + G  PF G N  +   L+E  +     
Sbjct: 218 YAAPELFQGKKYD---GPEVDVWSLGVILYTLVSGSLPFDGQNLKE---LRERVLRGKYR 271

Query: 695 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734
           + F     +S++ +  ++R L      R  + Q+  D ++
Sbjct: 272 IPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307


>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
           [Homo sapiens]
          Length = 729

 Score =  103 bits (258), Expect = 5e-22
 Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 29/280 (10%)

Query: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 515
           Y LL  +G+G F++V  A  +   R  A+KI       + +      +   RE RI K L
Sbjct: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPTSLQKLFREVRIMKIL 110

Query: 516 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 575
           +HP IVKL++    +  T   ++EY  G ++  YL  H  M EKEARS   QIV+A++Y 
Sbjct: 111 NHPNIVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169

Query: 576 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 635
           ++ +  I+H DLK  N+LL    A   IKI DFG S     + + V G   T  G+    
Sbjct: 170 HQKR--IVHRDLKAENLLL---DADMNIKIADFGFS-----NEFTVGGKLDTFCGSPP-- 217

Query: 636 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILKATE 694
           Y  PE F   K       +VDVWS+GVI +  + G  PF G N  +   L+E  +     
Sbjct: 218 YAAPELFQGKKYD---GPEVDVWSLGVILYTLVSGSLPFDGQNLKE---LRERVLRGKYR 271

Query: 695 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734
           + F     +S++ +  ++R L      R  + Q+  D ++
Sbjct: 272 IPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.131    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,790,861
Number of Sequences: 37866
Number of extensions: 1558415
Number of successful extensions: 10432
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 238
Number of HSP's successfully gapped in prelim test: 858
Number of HSP's that attempted gapping in prelim test: 7849
Number of HSP's gapped (non-prelim): 2285
length of query: 766
length of database: 18,247,518
effective HSP length: 110
effective length of query: 656
effective length of database: 14,082,258
effective search space: 9237961248
effective search space used: 9237961248
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.