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Search of human proteins with 33286428
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33286428 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform a [Homo sapiens]
(535 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33286428 solute carrier family 7 (cationic amino acid transpo... 1079 0.0
gi|9790235 solute carrier family 7, member 10 [Homo sapiens] 678 0.0
gi|33286430 solute carrier family 7 (cationic amino acid transpo... 677 0.0
gi|71979932 solute carrier family 7 (cationic amino acid transpo... 538 e-153
gi|115648063 solute carrier family 7 (cationic amino acid transp... 495 e-140
gi|115648022 solute carrier family 7 (cationic amino acid transp... 495 e-140
gi|186910308 solute carrier family 7 member 7 [Homo sapiens] 478 e-135
gi|186910306 solute carrier family 7 member 7 [Homo sapiens] 478 e-135
gi|186910304 solute carrier family 7 member 7 [Homo sapiens] 478 e-135
gi|7657683 solute carrier family 7, (cationic amino acid transpo... 421 e-118
gi|187423910 solute carrier family 7, member 9 [Homo sapiens] 387 e-107
gi|7657591 solute carrier family 7, member 9 [Homo sapiens] 387 e-107
gi|71999149 solute carrier family 7, (cationic amino acid transp... 229 6e-60
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s... 97 3e-20
gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo s... 97 3e-20
gi|110347453 solute carrier family 7 (cationic amino acid transp... 96 6e-20
gi|4507047 solute carrier family 7 (cationic amino acid transpor... 93 5e-19
gi|114326550 solute carrier family 7 (cationic amino acid transp... 87 5e-17
gi|114326544 solute carrier family 7 (cationic amino acid transp... 87 5e-17
gi|181337167 solute carrier family 7 (cationic amino acid transp... 72 1e-12
gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 52 1e-06
gi|4506975 solute carrier family 12 (sodium/potassium/chloride t... 48 2e-05
gi|123701900 solute carrier family 12 (potassium/chloride transp... 45 1e-04
gi|198041678 solute carrier family 12 (potassium-chloride transp... 45 2e-04
gi|11968148 solute carrier family 12 (potassium-chloride transpo... 45 2e-04
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 44 3e-04
gi|197333809 joined to JAZF1 [Homo sapiens] 35 0.13
gi|31881740 solute carrier family 12 (potassium/chloride transpo... 31 2.5
gi|30039714 otopetrin 2 [Homo sapiens] 31 3.2
gi|6912726 transmembrane 4 superfamily member 16 [Homo sapiens] 30 4.2
>gi|33286428 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform a [Homo
sapiens]
Length = 535
Score = 1079 bits (2790), Expect = 0.0
Identities = 535/535 (100%), Positives = 535/535 (100%)
Query: 1 MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFV 60
MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFV
Sbjct: 1 MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFV 60
Query: 61 SPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGF 120
SPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGF
Sbjct: 61 SPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGF 120
Query: 121 LRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSV 180
LRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSV
Sbjct: 121 LRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSV 180
Query: 181 RWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQ 240
RWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQ
Sbjct: 181 RWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQ 240
Query: 241 GSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASN 300
GSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASN
Sbjct: 241 GSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASN 300
Query: 301 AVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVK 360
AVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVK
Sbjct: 301 AVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVK 360
Query: 361 RCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPI 420
RCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPI
Sbjct: 361 RCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPI 420
Query: 421 KINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFI 480
KINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFI
Sbjct: 421 KINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFI 480
Query: 481 ELLTLVSQKMCVVVYPEVERGSGTEEANEDMEEQQQPMYQPTPTKDKDVAGQPQP 535
ELLTLVSQKMCVVVYPEVERGSGTEEANEDMEEQQQPMYQPTPTKDKDVAGQPQP
Sbjct: 481 ELLTLVSQKMCVVVYPEVERGSGTEEANEDMEEQQQPMYQPTPTKDKDVAGQPQP 535
>gi|9790235 solute carrier family 7, member 10 [Homo sapiens]
Length = 523
Score = 678 bits (1750), Expect = 0.0
Identities = 325/477 (68%), Positives = 396/477 (83%), Gaps = 3/477 (0%)
Query: 24 SPEAGSGGGG---VALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWI 80
SP G+ G VALKKEIGL+SAC II+GNIIGSGIF+SPKGVLE++GSVGLAL VW+
Sbjct: 21 SPVPGTVPGASERVALKKEIGLLSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWV 80
Query: 81 VTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIAL 140
+ G +T +G+LCYAELGV IPKSGGDY+YV +IFGGLAGFL LW AVL++YPT+ AVI++
Sbjct: 81 LGGGVTALGSLCYAELGVAIPKSGGDYAYVTEIFGGLAGFLLLWSAVLIMYPTSLAVISM 140
Query: 141 TFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALAL 200
TFSNYVLQP+FP C PP + R+L+ CL+LLTWVN SSVRWATR+QD+FT GKLLAL+L
Sbjct: 141 TFSNYVLQPVFPNCIPPTTASRVLSMACLMLLTWVNSSSVRWATRIQDMFTGGKLLALSL 200
Query: 201 IIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVD 260
II +G++QI +G + L P NAF + P +G +ALAFLQGSFA+ GWNFLNYVTEE+VD
Sbjct: 201 IIGVGLLQIFQGHFEELRPSNAFAFWMTPSVGHLALAFLQGSFAFSGWNFLNYVTEEMVD 260
Query: 261 PYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPI 320
KNLPRAIFISIPLVTFVY F N+AY TAMSPQELL+SNAVAVTFGEKLLG +W+MP+
Sbjct: 261 ARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELLSSNAVAVTFGEKLLGYFSWVMPV 320
Query: 321 SVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLV 380
SVALSTFGG+NG LFT SRL F+GAREGHLPS+LAMIHV+ CTPIPALL C +T ++++
Sbjct: 321 SVALSTFGGINGYLFTYSRLCFSGAREGHLPSLLAMIHVRHCTPIPALLVCCGATAVIML 380
Query: 381 TSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVF 440
D YTLINYV FINYL YGVT+ G ++LRW++P + RPIK+NLL P+ YL+FWAFLLVF
Sbjct: 381 VGDTYTLINYVSFINYLCYGVTILGLLLLRWRRPALHRPIKVNLLIPVAYLVFWAFLLVF 440
Query: 441 SLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPE 497
S SEP+VCG+G+ I+LTGVP++FLGV+W+ KPKC E +T Q++C VVYP+
Sbjct: 441 SFISEPMVCGVGVIIILTGVPIFFLGVFWRSKPKCVHRLTESMTHWGQELCFVVYPQ 497
>gi|33286430 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform b [Homo
sapiens]
Length = 332
Score = 677 bits (1746), Expect = 0.0
Identities = 332/332 (100%), Positives = 332/332 (100%)
Query: 204 MGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYK 263
MGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYK
Sbjct: 1 MGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYK 60
Query: 264 NLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVA 323
NLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVA
Sbjct: 61 NLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVA 120
Query: 324 LSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSD 383
LSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSD
Sbjct: 121 LSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSD 180
Query: 384 MYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLW 443
MYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLW
Sbjct: 181 MYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLW 240
Query: 444 SEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEVERGSG 503
SEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEVERGSG
Sbjct: 241 SEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEVERGSG 300
Query: 504 TEEANEDMEEQQQPMYQPTPTKDKDVAGQPQP 535
TEEANEDMEEQQQPMYQPTPTKDKDVAGQPQP
Sbjct: 301 TEEANEDMEEQQQPMYQPTPTKDKDVAGQPQP 332
>gi|71979932 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 5 [Homo sapiens]
Length = 507
Score = 538 bits (1385), Expect = e-153
Identities = 263/493 (53%), Positives = 354/493 (71%), Gaps = 2/493 (0%)
Query: 5 ARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKG 64
A + +K +D S AG G G V L++ I L++ IIVG IIGSGIFV+P G
Sbjct: 16 AEEKEEAREKMLAAKSADGSAPAGEGEG-VTLQRNITLLNGVAIIVGTIIGSGIFVTPTG 74
Query: 65 VLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLW 124
VL+ AGS GLAL+VW G ++VGALCYAELG TI KSGGDY+Y+ +++G L FL+LW
Sbjct: 75 VLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLW 134
Query: 125 IAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWAT 184
I +L+I P++Q ++AL F+ Y+L+PLFPTC PE +L+A +C+LLLT VNC SV+ AT
Sbjct: 135 IELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAAT 194
Query: 185 RVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFA 244
RVQD F A KLLALALII++G VQI KG+ L+P +FE + D+G + LA G FA
Sbjct: 195 RVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEG-TKLDVGNIVLALYSGLFA 253
Query: 245 YGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAV 304
YGGWN+LN+VTEE+++PY+NLP AI IS+P+VT VYV N+AY T +S +++L+S AVAV
Sbjct: 254 YGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAV 313
Query: 305 TFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTP 364
FG LGVM+WI+P+ V LS FG VNGSLFTSSRLFF G+REGHLPS+L+MIH + TP
Sbjct: 314 DFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTP 373
Query: 365 IPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINL 424
+P+L+FTC+ TLL + D++++IN+ F N+L + + G I LR +KP++ RPIK+NL
Sbjct: 374 VPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNL 433
Query: 425 LFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLT 484
P+ ++L FL+ S W PV CGIG I+L+G+PVYF GV+W++KPK I T
Sbjct: 434 ALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKNKPKWLLQGIFSTT 493
Query: 485 LVSQKMCVVVYPE 497
++ QK+ VV E
Sbjct: 494 VLCQKLMQVVPQE 506
>gi|115648063 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 6 [Homo sapiens]
Length = 515
Score = 495 bits (1274), Expect = e-140
Identities = 238/484 (49%), Positives = 343/484 (70%), Gaps = 9/484 (1%)
Query: 20 ESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVW 79
E D S + LKKEI L++ ++VGN+IGSGIFVSPKGVL + S G++LIVW
Sbjct: 25 EEDVSSPPQRSSETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIVW 84
Query: 80 IVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIA 139
+ G +VVGALCYAELG TI KSG Y+Y+ + FGG F+RLW+++LV+ PT QA+IA
Sbjct: 85 AIGGLFSVVGALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIA 144
Query: 140 LTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALA 199
+TF+NY++QP FP+C PP RLLAA C+ LLT+VNC+ V+W TRVQD FT K++AL
Sbjct: 145 ITFANYIIQPSFPSCDPPYLACRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALI 204
Query: 200 LIIIMGIVQICKG--EYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEE 257
II+MG+V++C+G E+F ++AFE D+G ++LA F+Y GW+ LN+VTEE
Sbjct: 205 AIIVMGLVKLCQGHSEHF----QDAFEG-SSWDMGNLSLALYSALFSYSGWDTLNFVTEE 259
Query: 258 LVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWI 317
+ +P +NLP AI IS+P+VT +Y+ NVAY T ++ ++L+S+AVAVTF ++ G+ +W
Sbjct: 260 IKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAVTFADQTFGMFSWT 319
Query: 318 MPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLL 377
+PI+VALS FGG+N S+F SSRLFF G+REGHLP +L+MIH++R TPIPALLF C L+
Sbjct: 320 IPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTPIPALLFNCTMALI 379
Query: 378 MLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFL 437
L+ D++ LINY F + F G++V GQ+ LRWK+P PRP+K+++ FPI++ + FL
Sbjct: 380 YLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWKEPKRPRPLKLSVFFPIVFCICSVFL 439
Query: 438 LVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYW--QHKPKCFSDFIELLTLVSQKMCVVVY 495
++ L+++ + IG+ I L+GVP YF+GVY +P + + +T +Q++C V
Sbjct: 440 VIVPLFTDTINSLIGIGIALSGVPFYFMGVYLPESRRPLFIRNVLAAITRGTQQLCFCVL 499
Query: 496 PEVE 499
E++
Sbjct: 500 TELD 503
>gi|115648022 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 6 [Homo sapiens]
Length = 515
Score = 495 bits (1274), Expect = e-140
Identities = 238/484 (49%), Positives = 343/484 (70%), Gaps = 9/484 (1%)
Query: 20 ESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVW 79
E D S + LKKEI L++ ++VGN+IGSGIFVSPKGVL + S G++LIVW
Sbjct: 25 EEDVSSPPQRSSETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIVW 84
Query: 80 IVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIA 139
+ G +VVGALCYAELG TI KSG Y+Y+ + FGG F+RLW+++LV+ PT QA+IA
Sbjct: 85 AIGGLFSVVGALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIA 144
Query: 140 LTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALA 199
+TF+NY++QP FP+C PP RLLAA C+ LLT+VNC+ V+W TRVQD FT K++AL
Sbjct: 145 ITFANYIIQPSFPSCDPPYLACRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALI 204
Query: 200 LIIIMGIVQICKG--EYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEE 257
II+MG+V++C+G E+F ++AFE D+G ++LA F+Y GW+ LN+VTEE
Sbjct: 205 AIIVMGLVKLCQGHSEHF----QDAFEG-SSWDMGNLSLALYSALFSYSGWDTLNFVTEE 259
Query: 258 LVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWI 317
+ +P +NLP AI IS+P+VT +Y+ NVAY T ++ ++L+S+AVAVTF ++ G+ +W
Sbjct: 260 IKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAVTFADQTFGMFSWT 319
Query: 318 MPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLL 377
+PI+VALS FGG+N S+F SSRLFF G+REGHLP +L+MIH++R TPIPALLF C L+
Sbjct: 320 IPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTPIPALLFNCTMALI 379
Query: 378 MLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFL 437
L+ D++ LINY F + F G++V GQ+ LRWK+P PRP+K+++ FPI++ + FL
Sbjct: 380 YLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWKEPKRPRPLKLSVFFPIVFCICSVFL 439
Query: 438 LVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYW--QHKPKCFSDFIELLTLVSQKMCVVVY 495
++ L+++ + IG+ I L+GVP YF+GVY +P + + +T +Q++C V
Sbjct: 440 VIVPLFTDTINSLIGIGIALSGVPFYFMGVYLPESRRPLFIRNVLAAITRGTQQLCFCVL 499
Query: 496 PEVE 499
E++
Sbjct: 500 TELD 503
>gi|186910308 solute carrier family 7 member 7 [Homo sapiens]
Length = 511
Score = 478 bits (1230), Expect = e-135
Identities = 246/514 (47%), Positives = 348/514 (67%), Gaps = 13/514 (2%)
Query: 9 NNTEKKHPGGGESDASP---EAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGV 65
++TE + E + SP A G V LKKEI L++ +IVGN+IGSGIFVSPKGV
Sbjct: 3 DSTEYEVASQPEVETSPLGDGASPGPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGV 62
Query: 66 LENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWI 125
L + S GL+L++W V G +V GALCYAELG TI KSG Y+Y+ + FGG F+RLW
Sbjct: 63 LIYSASFGLSLVIWAVGGLFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWT 122
Query: 126 AVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATR 185
++L+I PT+QA+IA+TF+NY++QPLFP+CF P + RLLAA C+ LLT++NC+ V+W T
Sbjct: 123 SLLIIEPTSQAIIAITFANYMVQPLFPSCFAPYAASRLLAAACICLLTFINCAYVKWGTL 182
Query: 186 VQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAY 245
VQDIFT K+LAL +I+ GIV++ +G E N+FE +G +ALA F+Y
Sbjct: 183 VQDIFTYAKVLALIAVIVAGIVRLGQGASTHFE--NSFEGSSFA-VGDIALALYSALFSY 239
Query: 246 GGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVT 305
GW+ LNYVTEE+ +P +NLP +I IS+P+VT +Y+ NVAY T + +++LAS+AVAVT
Sbjct: 240 SGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILASDAVAVT 299
Query: 306 FGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPI 365
F +++ G+ WI+P+SVALS FGG+N S+ +SRLFF G+REGHLP + MIHV+R TP+
Sbjct: 300 FADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGHLPDAICMIHVERFTPV 359
Query: 366 PALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLL 425
P+LLF I L+ L D++ LINY F + F G+++ GQ+ LRWK+PD PRP+K+++
Sbjct: 360 PSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWKEPDRPRPLKLSVF 419
Query: 426 FPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGV-YWQHK-PKCFSDFIELL 483
FPI++ L FL+ L+S+ + IG+AI L+G+P YFL + +HK P +
Sbjct: 420 FPIVFCLCTIFLVAVPLYSDTINSLIGIAIALSGLPFYFLIIRVPEHKRPLYLRRIVGSA 479
Query: 484 TLVSQKMCVVVYPEVERGSGTEEANEDMEEQQQP 517
T Q +C+ V E++ G E M +Q+ P
Sbjct: 480 TRYLQVLCMSVAAEMDLEDGGE-----MPKQRDP 508
>gi|186910306 solute carrier family 7 member 7 [Homo sapiens]
Length = 511
Score = 478 bits (1230), Expect = e-135
Identities = 246/514 (47%), Positives = 348/514 (67%), Gaps = 13/514 (2%)
Query: 9 NNTEKKHPGGGESDASP---EAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGV 65
++TE + E + SP A G V LKKEI L++ +IVGN+IGSGIFVSPKGV
Sbjct: 3 DSTEYEVASQPEVETSPLGDGASPGPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGV 62
Query: 66 LENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWI 125
L + S GL+L++W V G +V GALCYAELG TI KSG Y+Y+ + FGG F+RLW
Sbjct: 63 LIYSASFGLSLVIWAVGGLFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWT 122
Query: 126 AVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATR 185
++L+I PT+QA+IA+TF+NY++QPLFP+CF P + RLLAA C+ LLT++NC+ V+W T
Sbjct: 123 SLLIIEPTSQAIIAITFANYMVQPLFPSCFAPYAASRLLAAACICLLTFINCAYVKWGTL 182
Query: 186 VQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAY 245
VQDIFT K+LAL +I+ GIV++ +G E N+FE +G +ALA F+Y
Sbjct: 183 VQDIFTYAKVLALIAVIVAGIVRLGQGASTHFE--NSFEGSSFA-VGDIALALYSALFSY 239
Query: 246 GGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVT 305
GW+ LNYVTEE+ +P +NLP +I IS+P+VT +Y+ NVAY T + +++LAS+AVAVT
Sbjct: 240 SGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILASDAVAVT 299
Query: 306 FGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPI 365
F +++ G+ WI+P+SVALS FGG+N S+ +SRLFF G+REGHLP + MIHV+R TP+
Sbjct: 300 FADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGHLPDAICMIHVERFTPV 359
Query: 366 PALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLL 425
P+LLF I L+ L D++ LINY F + F G+++ GQ+ LRWK+PD PRP+K+++
Sbjct: 360 PSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWKEPDRPRPLKLSVF 419
Query: 426 FPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGV-YWQHK-PKCFSDFIELL 483
FPI++ L FL+ L+S+ + IG+AI L+G+P YFL + +HK P +
Sbjct: 420 FPIVFCLCTIFLVAVPLYSDTINSLIGIAIALSGLPFYFLIIRVPEHKRPLYLRRIVGSA 479
Query: 484 TLVSQKMCVVVYPEVERGSGTEEANEDMEEQQQP 517
T Q +C+ V E++ G E M +Q+ P
Sbjct: 480 TRYLQVLCMSVAAEMDLEDGGE-----MPKQRDP 508
>gi|186910304 solute carrier family 7 member 7 [Homo sapiens]
Length = 511
Score = 478 bits (1230), Expect = e-135
Identities = 246/514 (47%), Positives = 348/514 (67%), Gaps = 13/514 (2%)
Query: 9 NNTEKKHPGGGESDASP---EAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGV 65
++TE + E + SP A G V LKKEI L++ +IVGN+IGSGIFVSPKGV
Sbjct: 3 DSTEYEVASQPEVETSPLGDGASPGPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGV 62
Query: 66 LENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWI 125
L + S GL+L++W V G +V GALCYAELG TI KSG Y+Y+ + FGG F+RLW
Sbjct: 63 LIYSASFGLSLVIWAVGGLFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWT 122
Query: 126 AVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATR 185
++L+I PT+QA+IA+TF+NY++QPLFP+CF P + RLLAA C+ LLT++NC+ V+W T
Sbjct: 123 SLLIIEPTSQAIIAITFANYMVQPLFPSCFAPYAASRLLAAACICLLTFINCAYVKWGTL 182
Query: 186 VQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAY 245
VQDIFT K+LAL +I+ GIV++ +G E N+FE +G +ALA F+Y
Sbjct: 183 VQDIFTYAKVLALIAVIVAGIVRLGQGASTHFE--NSFEGSSFA-VGDIALALYSALFSY 239
Query: 246 GGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVT 305
GW+ LNYVTEE+ +P +NLP +I IS+P+VT +Y+ NVAY T + +++LAS+AVAVT
Sbjct: 240 SGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILASDAVAVT 299
Query: 306 FGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPI 365
F +++ G+ WI+P+SVALS FGG+N S+ +SRLFF G+REGHLP + MIHV+R TP+
Sbjct: 300 FADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGHLPDAICMIHVERFTPV 359
Query: 366 PALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLL 425
P+LLF I L+ L D++ LINY F + F G+++ GQ+ LRWK+PD PRP+K+++
Sbjct: 360 PSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWKEPDRPRPLKLSVF 419
Query: 426 FPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGV-YWQHK-PKCFSDFIELL 483
FPI++ L FL+ L+S+ + IG+AI L+G+P YFL + +HK P +
Sbjct: 420 FPIVFCLCTIFLVAVPLYSDTINSLIGIAIALSGLPFYFLIIRVPEHKRPLYLRRIVGSA 479
Query: 484 TLVSQKMCVVVYPEVERGSGTEEANEDMEEQQQP 517
T Q +C+ V E++ G E M +Q+ P
Sbjct: 480 TRYLQVLCMSVAAEMDLEDGGE-----MPKQRDP 508
>gi|7657683 solute carrier family 7, (cationic amino acid
transporter, y+ system) member 11 [Homo sapiens]
Length = 501
Score = 421 bits (1082), Expect = e-118
Identities = 213/467 (45%), Positives = 311/467 (66%), Gaps = 4/467 (0%)
Query: 34 VALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCY 93
V LK+++ L+ II+G IIG+GIF+SPKGVL+N GSVG++L +W V G +++ GAL Y
Sbjct: 38 VQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSY 97
Query: 94 AELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPT 153
AELG TI KSGG Y+Y+ ++FG L F+R+W+ +L+I P AVI+L F Y+L+P F
Sbjct: 98 AELGTTIKKSGGHYTYILEVFGPLPAFVRVWVELLIIRPAATAVISLAFGRYILEPFFIQ 157
Query: 154 CFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGE 213
C PE ++L+ A+ + ++ +N SV W+ R+Q T KL A+ +II+ G++Q+ KG+
Sbjct: 158 CEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVMQLIKGQ 217
Query: 214 YFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISI 273
K+AF ++ I + LAF G +AY GW +LN+VTEE+ +P K +P AI IS+
Sbjct: 218 T--QNFKDAFSG-RDSSITRLPLAFYYGMYAYAGWFYLNFVTEEVENPEKTIPLAICISM 274
Query: 274 PLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGS 333
+VT YV NVAY T ++ +ELL SNAVAVTF E+LLG + +PI VALS FG +NG
Sbjct: 275 AIVTIGYVLTNVAYFTTINAEELLLSNAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGG 334
Query: 334 LFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGF 393
+F SRLF+ +REGHLP +L+MIHV++ TP+PA++ T++ML + D+ +L+N++ F
Sbjct: 335 VFAVSRLFYVASREGHLPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSF 394
Query: 394 INYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGL 453
+LF G+ VAG I LR+K PD+ RP K+ L P ++ F++ SL+S+P GIG
Sbjct: 395 ARWLFIGLAVAGLIYLRYKCPDMHRPFKVPLFIPALFSFTCLFMVALSLYSDPFSTGIGF 454
Query: 454 AIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEVER 500
I LTGVP Y+L + W KP+ F E +T Q + VV PE ++
Sbjct: 455 VITLTGVPAYYLFIIWDKKPRWFRIMSEKITRTLQIILEVV-PEEDK 500
>gi|187423910 solute carrier family 7, member 9 [Homo sapiens]
Length = 487
Score = 387 bits (993), Expect = e-107
Identities = 199/440 (45%), Positives = 292/440 (66%), Gaps = 10/440 (2%)
Query: 35 ALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYA 94
+L+KE+GL+S IIVG IIGSGIFVSPK VL N +VG LI+W G + +GALC+A
Sbjct: 25 SLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLATLGALCFA 84
Query: 95 ELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTC 154
ELG I KSGG+Y Y+ + +G + +L W +++VI PT+ A+I L+FS YV P + C
Sbjct: 85 ELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLIVIKPTSFAIICLSFSEYVCAPFYVGC 144
Query: 155 FPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEY 214
PP+ ++ LAA +L ++ VN SVR + VQ+IFTA KL+ +A+III G+V + +G
Sbjct: 145 KPPQIVVKCLAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAIIIISGLVLLAQGNT 204
Query: 215 FWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIP 274
+ N+FE Q +G ++LAF G +AY GWN LNY+TEEL +PY+NLP AI I IP
Sbjct: 205 KNFD--NSFEGAQL-SVGAISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPLAIIIGIP 261
Query: 275 LVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSL 334
LVT Y+ NV+Y T M+ ELL S AVAVTFG+++L +WI+P+ VA ST G NG+
Sbjct: 262 LVTACYILMNVSYFTVMTATELLQSQAVAVTFGDRVLYPASWIVPLFVAFSTIGAANGTC 321
Query: 335 FTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFI 394
FT+ RL + REGH+ VL+ I V+R TP PA++F I + ++ D+ +L+NY F
Sbjct: 322 FTAGRLIYVAGREGHMLKVLSYISVRRLTPAPAIIFYGIIATIYIIPGDINSLVNYFSFA 381
Query: 395 NYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEP----VVCG 450
+LFYG+T+ G IV+R+ + ++ RPIK+ ++ P++ L FL++ + S+P + C
Sbjct: 382 AWLFYGLTILGLIVMRFTRKELERPIKVPVVIPVLMTLISVFLVLAPIISKPTWEYLYC- 440
Query: 451 IGLAIMLTGVPVYFLGVYWQ 470
+ +L+G+ YFL V+++
Sbjct: 441 --VLFILSGLLFYFLFVHYK 458
>gi|7657591 solute carrier family 7, member 9 [Homo sapiens]
Length = 487
Score = 387 bits (993), Expect = e-107
Identities = 199/440 (45%), Positives = 292/440 (66%), Gaps = 10/440 (2%)
Query: 35 ALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYA 94
+L+KE+GL+S IIVG IIGSGIFVSPK VL N +VG LI+W G + +GALC+A
Sbjct: 25 SLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLATLGALCFA 84
Query: 95 ELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTC 154
ELG I KSGG+Y Y+ + +G + +L W +++VI PT+ A+I L+FS YV P + C
Sbjct: 85 ELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLIVIKPTSFAIICLSFSEYVCAPFYVGC 144
Query: 155 FPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEY 214
PP+ ++ LAA +L ++ VN SVR + VQ+IFTA KL+ +A+III G+V + +G
Sbjct: 145 KPPQIVVKCLAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAIIIISGLVLLAQGNT 204
Query: 215 FWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIP 274
+ N+FE Q +G ++LAF G +AY GWN LNY+TEEL +PY+NLP AI I IP
Sbjct: 205 KNFD--NSFEGAQL-SVGAISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPLAIIIGIP 261
Query: 275 LVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSL 334
LVT Y+ NV+Y T M+ ELL S AVAVTFG+++L +WI+P+ VA ST G NG+
Sbjct: 262 LVTACYILMNVSYFTVMTATELLQSQAVAVTFGDRVLYPASWIVPLFVAFSTIGAANGTC 321
Query: 335 FTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFI 394
FT+ RL + REGH+ VL+ I V+R TP PA++F I + ++ D+ +L+NY F
Sbjct: 322 FTAGRLIYVAGREGHMLKVLSYISVRRLTPAPAIIFYGIIATIYIIPGDINSLVNYFSFA 381
Query: 395 NYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEP----VVCG 450
+LFYG+T+ G IV+R+ + ++ RPIK+ ++ P++ L FL++ + S+P + C
Sbjct: 382 AWLFYGLTILGLIVMRFTRKELERPIKVPVVIPVLMTLISVFLVLAPIISKPTWEYLYC- 440
Query: 451 IGLAIMLTGVPVYFLGVYWQ 470
+ +L+G+ YFL V+++
Sbjct: 441 --VLFILSGLLFYFLFVHYK 458
>gi|71999149 solute carrier family 7, (cationic amino acid
transporter, y+ system) member 13 [Homo sapiens]
Length = 470
Score = 229 bits (583), Expect = 6e-60
Identities = 143/458 (31%), Positives = 246/458 (53%), Gaps = 18/458 (3%)
Query: 31 GGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLE-NAGSVGLALIVWIVTGFITVVG 89
G + LK+ G ++ NIIG+GIFVSPKGVL + +VG++L VW + +
Sbjct: 4 GEKIQLKRVFGYWWGTSFLLINIIGAGIFVSPKGVLAYSCMNVGVSLCVWAGCAILAMTS 63
Query: 90 ALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIA---LTFSNYV 146
LC AE+ ++ P SG Y ++K FG FL LW ++ + V+A L + Y
Sbjct: 64 TLCSAEISISFPCSGAQYYFLKRYFGSTVAFLNLWTSLFL----GSGVVAGQALLLAEYS 119
Query: 147 LQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGI 206
+QP FP+C P+ + LA L ++ + V+ T +Q + K+ L+ I + G+
Sbjct: 120 IQPFFPSCSVPKLPKKCLALAMLWIVGILTSRGVKEVTWLQIASSVLKVSILSFISLTGV 179
Query: 207 VQICKGEYFWLEP-KNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNL 265
V + +G+ +E +NAF+ + PDI + A QG FAY G + EL P +
Sbjct: 180 VFLIRGKKENVERFQNAFDA-ELPDISHLIQAIFQGYFAYSGGACFTLIAGELKKPRTTI 238
Query: 266 PRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALS 325
P+ IF ++PLVT VY+ N++Y+T ++P+E+L+S+AVA+T+ ++ +AWIMP +++ S
Sbjct: 239 PKCIFTALPLVTVVYLLVNISYLTVLTPREILSSDAVAITWADRAFPSLAWIMPFAISTS 298
Query: 326 TFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMY 385
F + S+F SSR + ++EG LP + ++ +P A+L L ++ + +
Sbjct: 299 LFSNLLISIFKSSRPIYLASQEGQLPLLFNTLN-SHSSPFTAVLLLVTLGSLAIILTSLI 357
Query: 386 TLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSE 445
LINY+ F L+ + + G + R+++P++ P K+ L FP+ ++ L+V L
Sbjct: 358 DLINYIFFTGSLWSILLMIGILRRRYQEPNLSIPYKVFLSFPLATIVIDVGLVVIPLVKS 417
Query: 446 PVVCGI-GLAIMLTGVPVYF------LGVYWQHKPKCF 476
P V + L ++L+G+ Y + + W K C+
Sbjct: 418 PNVHYVYVLLLVLSGLLFYIPLIHFKIRLAWFEKMTCY 455
>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
sapiens]
Length = 697
Score = 97.4 bits (241), Expect = 3e-20
Identities = 101/395 (25%), Positives = 175/395 (44%), Gaps = 36/395 (9%)
Query: 50 VGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSY 109
VG+ +G+G++V G + A S ++ +++ +V+ LCYAE G +PK+G Y Y
Sbjct: 84 VGSTLGAGVYVLA-GEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLY 142
Query: 110 VKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFS-----------NYVLQPLFPTCFPPE 158
G L F+ W +L Y + +A +S L+ F +
Sbjct: 143 TYVTVGELWAFITGWNLIL-SYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGL 201
Query: 159 SGLRLLAAICL-LLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWL 217
+ A+CL LLL + V+ + V +FTA +L L +++ G V+ +
Sbjct: 202 AEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKIS 261
Query: 218 EP--KNAFENFQEPDI----------GLVALAF---LQGS----FAYGGWNFLNYVTEEL 258
E KN + +EP G + F L G+ +A+ G++ + EE+
Sbjct: 262 EEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEV 321
Query: 259 VDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELL-ASNAVAVTFGEKLLGVMAWI 317
+P K +P I S+ LV F+ F A +T M P LL + + V F G ++
Sbjct: 322 RNPQKAIPIGIVTSL-LVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYV 380
Query: 318 MPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLL 377
+ + + GS+F R+ FA AR+G L LA + KR +P+ A L + + L
Sbjct: 381 VAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVS-KRQSPVAATLTAGVISAL 439
Query: 378 MLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWK 412
M D+ L++ + + Y + A ++LR++
Sbjct: 440 MAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQ 474
>gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo
sapiens]
Length = 658
Score = 97.4 bits (241), Expect = 3e-20
Identities = 101/395 (25%), Positives = 173/395 (43%), Gaps = 35/395 (8%)
Query: 50 VGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSY 109
VG+ +G+G++V G + A S ++ +++ +V+ LCYAE G +PK+G Y Y
Sbjct: 44 VGSTLGAGVYVLA-GEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLY 102
Query: 110 VKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFS-----------NYVLQPLFPTCFPPE 158
G L F+ W +L Y + +A +S L+ F +
Sbjct: 103 TYVTVGELWAFITGWNLIL-SYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGL 161
Query: 159 SGLRLLAAICL-LLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWL 217
+ A+CL LLL + V+ + V +FTA +L L +++ G V+ +
Sbjct: 162 AEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKIS 221
Query: 218 EP--KNAFENFQEPDI----------GLVALAF---LQGS----FAYGGWNFLNYVTEEL 258
E KN + +EP G + F L G+ +A+ G++ + EE+
Sbjct: 222 EEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEV 281
Query: 259 VDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELL-ASNAVAVTFGEKLLGVMAWI 317
+P K +P I S+ LV F+ F A +T M P LL + + V F G ++
Sbjct: 282 RNPQKAIPIGIVTSL-LVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYV 340
Query: 318 MPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLL 377
+ + + GS+F R+ +A A +G L LA I+ K TPI A L + L
Sbjct: 341 VAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAAL 400
Query: 378 MLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWK 412
M D+ L++ + + Y + A ++LR++
Sbjct: 401 MAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQ 435
>gi|110347453 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 4 [Homo sapiens]
Length = 635
Score = 96.3 bits (238), Expect = 6e-20
Identities = 91/383 (23%), Positives = 163/383 (42%), Gaps = 24/383 (6%)
Query: 50 VGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSY 109
VG ++GSG++V V + + L+ + V +++ ALCYAE G +P++G Y +
Sbjct: 47 VGGMVGSGLYVLTGAVAKEVAGPAV-LLSFGVAAVASLLAALCYAEFGARVPRTGSAYLF 105
Query: 110 VKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLR------- 162
G L FL W VL+ Y A +A +S Y L +F +
Sbjct: 106 TYVSMGELWAFLIGW-NVLLEYIIGGAAVARAWSGY-LDSMFSHSIRNFTETHVGSWQVP 163
Query: 163 --------LLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEY 214
L A I LL +V+C + R ++ + F+A LL + I+I+G I +
Sbjct: 164 LLGHYPDFLAAGIILLASAFVSCGA-RVSSWLNHTFSAISLLVILFIVILGF--ILAQPH 220
Query: 215 FWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIP 274
W + F F V +A+ G++ + +EE +P +++P AI IS+
Sbjct: 221 NWSADEGGFAPF---GFSGVMAGTASCFYAFVGFDVIAASSEEAQNPRRSVPLAIAISLA 277
Query: 275 LVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSL 334
+ Y+ + + L +A+A F ++ +I+ + + L
Sbjct: 278 IAAGAYILVSTVLTLMVPWHSLDPDSALADAFYQRGYRWAGFIVAAGSICAMNTVLLSLL 337
Query: 335 FTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFI 394
F+ R+ +A A +G V A +H + P+ L + T + + D+ +L+ ++
Sbjct: 338 FSLPRIVYAMAADGLFFQVFAHVHPRTQVPVAGTLAFGLLTAFLALLLDLESLVQFLSLG 397
Query: 395 NYLFYGVTVAGQIVLRWKKPDIP 417
L Y IVLR++K P
Sbjct: 398 TLLAYTFVATSIIVLRFQKSSPP 420
>gi|4507047 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 1 [Homo sapiens]
Length = 629
Score = 93.2 bits (230), Expect = 5e-19
Identities = 103/403 (25%), Positives = 175/403 (43%), Gaps = 42/403 (10%)
Query: 50 VGNIIGSGIFVSPKGVL-ENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYS 108
VG+ +G+G++V V ENAG +I +++ +V+ LCY E G +PK+G Y
Sbjct: 42 VGSTLGAGVYVLAGAVARENAGPA--IVISFLIAALASVLAGLCYGEFGARVPKTGSAYL 99
Query: 109 YVKDIFGGLAGFLRLWIAVLVIYPTNQAVI---ALTFSNYVLQPL------FPTCFPP-- 157
Y G L F+ W +L +V + TF + +P+ T P
Sbjct: 100 YSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGV 159
Query: 158 -ESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEY-F 215
+ A I +L+LT + V+ + V IFT +L L I++ G V KG
Sbjct: 160 LAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSGFV---KGSVKN 216
Query: 216 WLEPKNAFENFQ------------EPDI-GLVALAF---LQGS----FAYGGWNFLNYVT 255
W + F N +P + G + F L G+ +A+ G++ +
Sbjct: 217 WQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTG 276
Query: 256 EELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNA-VAVTFGEKLLGVM 314
EE+ +P K +P I S+ L+ F+ F A +T M P L +N+ + F
Sbjct: 277 EEVKNPQKAIPVGIVASL-LICFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGA 335
Query: 315 AWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCIS 374
+ + + + + GS+F R+ +A A +G L LA ++ + TPI A L +
Sbjct: 336 KYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAV 395
Query: 375 TLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIP 417
+M D+ L++ + L Y + A +VLR+ +P+ P
Sbjct: 396 AAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRY-QPEQP 437
>gi|114326550 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 86.7 bits (213), Expect = 5e-17
Identities = 111/517 (21%), Positives = 205/517 (39%), Gaps = 83/517 (16%)
Query: 29 SGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVV 88
SG L + + + + VG+ +G+G++V V ++ + +I ++V +V+
Sbjct: 21 SGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSI-VICFLVAALSSVL 79
Query: 89 GALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFS----- 143
LCYAE G +P+SG Y Y G L F W +L Y A +A +S
Sbjct: 80 AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLIL-SYVIGTASVARAWSSAFDN 138
Query: 144 ---NYVLQPLFPTC----------FPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIF 190
N++ + L + +P L L +LLLT + + V +F
Sbjct: 139 LIGNHISKTLQGSIALHVPHVLAEYPDFFALGL-----VLLLTGLLALGASESALVTKVF 193
Query: 191 TAGKLLALALIIIMGIV-------QICKGEY--FWLEPKNAFENFQEPDIGLVALAF--- 238
T LL L ++I G V ++ + +Y E + + G V F
Sbjct: 194 TGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGI 253
Query: 239 LQGS----FAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQ 294
L+G+ +A+ G++ + EE +P +++P I IS+ + Y + A M
Sbjct: 254 LRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYY 313
Query: 295 ELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVL 354
+L + + F +++ + + + GS+F R+ +A A +G L VL
Sbjct: 314 QLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVL 373
Query: 355 AMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKP 414
A IH TPI A + + I M + L++ + L Y + ++LR+ +P
Sbjct: 374 ARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRY-QP 432
Query: 415 D----------------------------------IPRPIKINLLF---PIIYLLFWAFL 437
D IP P+ +++ ++ +L A
Sbjct: 433 DQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLLTALC 492
Query: 438 LVFSLWSEPVVCG----IGLAIMLTGVPVYFLGVYWQ 470
LV + WS P++ G + ++L + + + V W+
Sbjct: 493 LVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWR 529
>gi|114326544 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 86.7 bits (213), Expect = 5e-17
Identities = 111/517 (21%), Positives = 205/517 (39%), Gaps = 83/517 (16%)
Query: 29 SGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVV 88
SG L + + + + VG+ +G+G++V V ++ + +I ++V +V+
Sbjct: 21 SGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSI-VICFLVAALSSVL 79
Query: 89 GALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFS----- 143
LCYAE G +P+SG Y Y G L F W +L Y A +A +S
Sbjct: 80 AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLIL-SYVIGTASVARAWSSAFDN 138
Query: 144 ---NYVLQPLFPTC----------FPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIF 190
N++ + L + +P L L +LLLT + + V +F
Sbjct: 139 LIGNHISKTLQGSIALHVPHVLAEYPDFFALGL-----VLLLTGLLALGASESALVTKVF 193
Query: 191 TAGKLLALALIIIMGIV-------QICKGEY--FWLEPKNAFENFQEPDIGLVALAF--- 238
T LL L ++I G V ++ + +Y E + + G V F
Sbjct: 194 TGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGI 253
Query: 239 LQGS----FAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQ 294
L+G+ +A+ G++ + EE +P +++P I IS+ + Y + A M
Sbjct: 254 LRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYY 313
Query: 295 ELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVL 354
+L + + F +++ + + + GS+F R+ +A A +G L VL
Sbjct: 314 QLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVL 373
Query: 355 AMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKP 414
A IH TPI A + + I M + L++ + L Y + ++LR+ +P
Sbjct: 374 ARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRY-QP 432
Query: 415 D----------------------------------IPRPIKINLLF---PIIYLLFWAFL 437
D IP P+ +++ ++ +L A
Sbjct: 433 DQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLLTALC 492
Query: 438 LVFSLWSEPVVCG----IGLAIMLTGVPVYFLGVYWQ 470
LV + WS P++ G + ++L + + + V W+
Sbjct: 493 LVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWR 529
>gi|181337167 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 14 [Homo sapiens]
Length = 771
Score = 72.4 bits (176), Expect = 1e-12
Identities = 89/403 (22%), Positives = 169/403 (41%), Gaps = 39/403 (9%)
Query: 33 GVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALC 92
G L + + V + VG+ +G+G++V V + G+ ++ +I+ +++ +C
Sbjct: 46 GTKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEMAGPGV-IVSFIIAAVASILSGVC 104
Query: 93 YAELGVTIPK-SGGDYSYVKDIFGGLAGFLRLWIAVL-VIYPTNQAVIAL-----TFSNY 145
YAE GV +PK +G Y+Y G F W +L + T AL + +N+
Sbjct: 105 YAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANH 164
Query: 146 VLQPLFPTCFPPESGL--------RLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLA 197
+ +GL LLA + +++T + V+ + ++ L
Sbjct: 165 TISRWMADSVGTLNGLGKGEESYPDLLALLIAVIVTIIVALGVKNSIGFNNVLNVLNLAV 224
Query: 198 LALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGS----FAYGGWNFLNY 253
I+I G+ I G+Y W E + + LQG+ +A+ G++ +
Sbjct: 225 WVFIMIAGLFFI-NGKY-WAEGQFLPHGWS---------GVLQGAATCFYAFIGFDIIAT 273
Query: 254 VTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGV 313
EE +P ++P AI S+ + YV +V +T M P + + + + E +
Sbjct: 274 TGEEAKNPNTSIPYAITASLVICLTAYVSVSV-ILTLMVPYYTIDTESPLM---EMFVAH 329
Query: 314 MAWIMPISVALSTFGGVN----GSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALL 369
+ VA+ + G+ GSLF R+ +A A +G L LA + TP+ A +
Sbjct: 330 GFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTETPVVACI 389
Query: 370 FTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWK 412
+ L+ + + LI + L Y + ++LR++
Sbjct: 390 VSGFLAALLALLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQ 432
>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
Length = 714
Score = 52.4 bits (124), Expect = 1e-06
Identities = 77/383 (20%), Positives = 160/383 (41%), Gaps = 48/383 (12%)
Query: 41 GLVSACGIIVGNIIGSGIFVSPKGVLENAGSV-GLALIVWIV-TGFITVVGALCYAELGV 98
G+ ++C I NI G +F+ ++ N G + G+ L+ +++ +TV+ + E
Sbjct: 44 GVFTSCMI---NIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSS 100
Query: 99 TIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPE 158
SGG YS + + GG G + ++Y Q V + + +
Sbjct: 101 I--GSGGVYSMISSVLGGQTGG-----TIGLLYVFGQCVAGAMYITGFAESISDLLGLGN 153
Query: 159 S-GLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWL 217
+R ++ LL L +N + V+W R+Q L L ++ + + G + L
Sbjct: 154 IWAVRGISVAVLLALLGINLAGVKWIIRLQ--------LLLLFLLAVSTLDFVVGSFTHL 205
Query: 218 EPKNAF--------ENFQEPDIG-------LVALAFLQGSFAYGGWNFLNYVTEELVDPY 262
+P++ F +N PD + + F + G+N + +L +P
Sbjct: 206 DPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGFN----MGGDLREPA 261
Query: 263 KNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISV 322
++P ++ + F+Y+ V + A+ +E L + + EK + +M ++ + +
Sbjct: 262 ASIPLGSLAAVGISWFLYI-VFVFLLGAICTREALRYDFL---IAEK-VSLMGFLFLLGL 316
Query: 323 ALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVK--RCTPIPALLFTCISTLLMLV 380
+S+ G L+ + R+ A+E +P++ + K TP+ A+ T + T+ +
Sbjct: 317 YISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVF 376
Query: 381 TSDMYTLINYVGFINYLFYGVTV 403
+ L V IN++ V V
Sbjct: 377 VGQVNVLAPIV-TINFMLTYVAV 398
>gi|4506975 solute carrier family 12 (sodium/potassium/chloride
transporters), member 2 [Homo sapiens]
Length = 1212
Score = 48.1 bits (113), Expect = 2e-05
Identities = 54/255 (21%), Positives = 109/255 (42%), Gaps = 43/255 (16%)
Query: 52 NIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVT-IPKSGGDYSYV 110
NI G +F+ ++ AG +GL+++V ++ +T + L + + + GG Y +
Sbjct: 298 NIWGVMLFIRLSWIVGQAG-IGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLI 356
Query: 111 KDI----FGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFP---TCFPPESGLRL 163
FGG G + + + + A+ + F+ V++ L + +R+
Sbjct: 357 SRSLGPEFGGAIGLIFAFANAVAV-----AMYVVGFAETVVELLKEHSILMIDEINDIRI 411
Query: 164 LAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLE---PK 220
+ AI +++L ++ + + W + Q + L +I+++ I G + LE PK
Sbjct: 412 IGAITVVILLGISVAGMEWEAKAQ--------IVLLVILLLAIGDFVIGTFIPLESKKPK 463
Query: 221 NAF--------ENF------QEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLP 266
F ENF +E + A+ F + G N ++ +L DP +P
Sbjct: 464 GFFGYKSEIFNENFGPDFREEETFFSVFAIFFPAATGILAGAN----ISGDLADPQSAIP 519
Query: 267 RAIFISIPLVTFVYV 281
+ ++I + T VYV
Sbjct: 520 KGTLLAILITTLVYV 534
>gi|123701900 solute carrier family 12 (potassium/chloride
transporters), member 7 [Homo sapiens]
Length = 1083
Score = 45.4 bits (106), Expect = 1e-04
Identities = 44/162 (27%), Positives = 73/162 (45%), Gaps = 9/162 (5%)
Query: 257 ELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAW 316
+L D K++P ++I +F+Y+ V + + L A+ G ++G++AW
Sbjct: 443 DLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQ-GNLVIGMLAW 501
Query: 317 IMP----ISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVK-RCTPIPALLFT 371
P I ST G SL + RL A AR+G +P + H K P ALL T
Sbjct: 502 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLT 561
Query: 372 ---CISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLR 410
C + +L+ + +++ + YLF + A Q +LR
Sbjct: 562 VLICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLR 603
>gi|198041678 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 1 [Homo sapiens]
Length = 1139
Score = 44.7 bits (104), Expect = 2e-04
Identities = 53/206 (25%), Positives = 92/206 (44%), Gaps = 25/206 (12%)
Query: 257 ELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAW 316
+L D K++P ++I + VY+ + V + + L AV G ++G +AW
Sbjct: 446 DLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN-GNLVVGTLAW 504
Query: 317 IMP----ISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVK-RCTPIPALLFT 371
P I ST G SL + RL A +R+G +P + H K P ALL T
Sbjct: 505 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLT 564
Query: 372 -CISTLLMLVTS--DMYTLINYVGFINYLFYGVTVAGQIVLR---WKKPDIPR------- 418
CI + +L+ S ++ +++ + Y+F + A Q +LR W+ PR
Sbjct: 565 ACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWR----PRFRYYHWT 620
Query: 419 --PIKINLLFPIIYLLFWAFLLVFSL 442
+ ++L ++++ W + LV L
Sbjct: 621 LSFLGMSLCLALMFICSWYYALVAML 646
>gi|11968148 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 2 [Homo sapiens]
Length = 1116
Score = 44.7 bits (104), Expect = 2e-04
Identities = 53/206 (25%), Positives = 92/206 (44%), Gaps = 25/206 (12%)
Query: 257 ELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAW 316
+L D K++P ++I + VY+ + V + + L AV G ++G +AW
Sbjct: 423 DLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN-GNLVVGTLAW 481
Query: 317 IMP----ISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVK-RCTPIPALLFT 371
P I ST G SL + RL A +R+G +P + H K P ALL T
Sbjct: 482 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLT 541
Query: 372 -CISTLLMLVTS--DMYTLINYVGFINYLFYGVTVAGQIVLR---WKKPDIPR------- 418
CI + +L+ S ++ +++ + Y+F + A Q +LR W+ PR
Sbjct: 542 ACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWR----PRFRYYHWT 597
Query: 419 --PIKINLLFPIIYLLFWAFLLVFSL 442
+ ++L ++++ W + LV L
Sbjct: 598 LSFLGMSLCLALMFICSWYYALVAML 623
>gi|134254459 sodium potassium chloride cotransporter 2 [Homo
sapiens]
Length = 1099
Score = 44.3 bits (103), Expect = 3e-04
Identities = 55/281 (19%), Positives = 117/281 (41%), Gaps = 31/281 (11%)
Query: 19 GESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIV 78
G+ A + G V G++ C + NI G +F+ ++ AG +GL +++
Sbjct: 160 GDEQAENKEDDQAGVVKFGWVKGVLVRCML---NIWGVMLFIRLSWIVGEAG-IGLGVLI 215
Query: 79 WIVTGFITVVGALCYAELGVT-IPKSGGDYSYVKDI----FGGLAGFLRLWIAVLVIYPT 133
+++ +T + L + + + GG Y + FGG G + + + +
Sbjct: 216 ILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAV--- 272
Query: 134 NQAVIALTFSNYVLQPLFPT---CFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIF 190
A+ + F+ V+ L + P + +R++ +I +++L ++ + + W + Q I
Sbjct: 273 --AMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVIL 330
Query: 191 TAGKLLALALIIIMGIVQICKGE----YFWLEPKNAFENFQ------EPDIGLVALAFLQ 240
L+A+A I ++ + +F + ENF E + A+ F
Sbjct: 331 LVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPA 390
Query: 241 GSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYV 281
+ G N ++ +L DP +PR ++I + T Y+
Sbjct: 391 ATGILAGAN----ISGDLEDPQDAIPRGTMLAIFITTVAYL 427
>gi|197333809 joined to JAZF1 [Homo sapiens]
Length = 739
Score = 35.4 bits (80), Expect = 0.13
Identities = 22/66 (33%), Positives = 29/66 (43%), Gaps = 1/66 (1%)
Query: 13 KKHPGGGESDASPEAGSGGGGVALKKEIGLVSAC-GIIVGNIIGSGIFVSPKGVLENAGS 71
+KH GGG + P AGSGGGG + +A G G G G S A +
Sbjct: 4 QKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAA 63
Query: 72 VGLALI 77
G A++
Sbjct: 64 AGAAVL 69
>gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
Length = 914
Score = 31.2 bits (69), Expect = 2.5
Identities = 38/171 (22%), Positives = 70/171 (40%), Gaps = 19/171 (11%)
Query: 257 ELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLAS------NAVAVTFGEKL 310
EL DP + +P +++ FVYV + ++++ + L A+++ L
Sbjct: 290 ELKDPSRAIPLGTIVAVAYTFFVYVL--LFFLSSFTCDRTLLQEDYGFFRAISLWPPLVL 347
Query: 311 LGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHV--KRCTPIPAL 368
+G+ A + S++ SL +SR+ A AR+ +LA V + P A+
Sbjct: 348 IGIYATALSASMS---------SLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAV 398
Query: 369 LFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRP 419
L++ L+L+ + TL V + Y + L W RP
Sbjct: 399 LYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRP 449
>gi|30039714 otopetrin 2 [Homo sapiens]
Length = 562
Score = 30.8 bits (68), Expect = 3.2
Identities = 29/118 (24%), Positives = 50/118 (42%), Gaps = 9/118 (7%)
Query: 187 QDIFTAGKLLALALII------IMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQ 240
++ F AG +L L L + I+ VQ+ + + +F +GL L L
Sbjct: 286 RETFFAGPVLGLLLFVVGLAVFIIYEVQVSGDGSRTRQALVIYYSFNIVCLGLTTLVSLS 345
Query: 241 GSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLA 298
GS Y F + +P + L A+ + L + + ++ V A +PQ+LLA
Sbjct: 346 GSIIY---RFDRRAMDHHKNPTRTLDVALLMGAALGQYAISYYSIVAVVAGTPQDLLA 400
>gi|6912726 transmembrane 4 superfamily member 16 [Homo sapiens]
Length = 245
Score = 30.4 bits (67), Expect = 4.2
Identities = 27/109 (24%), Positives = 48/109 (44%), Gaps = 7/109 (6%)
Query: 35 ALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYA 94
+LKK + L++ G + SGI + G+ G L ++ + + ++ VG LC
Sbjct: 10 SLKKLLSLLN------GFVAVSGIILVGLGIGGKCGGASLTNVLGLSSAYLLHVGNLCLV 63
Query: 95 ELGVTIPKS-GGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTF 142
+T+ G Y K+ G L + + VL++ T V+ L F
Sbjct: 64 MGCITVLLGCAGWYGATKESRGTLLFCILSMVIVLIMEVTAATVVLLFF 112
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.142 0.442
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,315,793
Number of Sequences: 37866
Number of extensions: 973397
Number of successful extensions: 4193
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 4119
Number of HSP's gapped (non-prelim): 44
length of query: 535
length of database: 18,247,518
effective HSP length: 107
effective length of query: 428
effective length of database: 14,195,856
effective search space: 6075826368
effective search space used: 6075826368
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.