Search of human proteins with 33188449

Search of human proteins with 33188449

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|33188449 serine/arginine-rich protein-specific kinase 2
isoform a [Homo sapiens]
         (699 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|33188449 serine/arginine-rich protein-specific kinase 2 isofo...  1446   0.0  
gi|33188447 serine/arginine-rich protein-specific kinase 2 isofo...  1401   0.0  
gi|47419936 SFRS protein kinase 1 [Homo sapiens]                      781   0.0  
gi|63025196 serine arginine rich protein-specific kinase 3 [Homo...   428   e-119
gi|47717134 CDC-like kinase 2 [Homo sapiens]                           98   2e-20
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]                96   9e-20
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]                96   9e-20
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula...    94   6e-19
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula...    94   6e-19
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]                92   2e-18
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]                 92   2e-18
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul...    90   6e-18
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat...    90   6e-18
gi|10190706 CDC-like kinase 4 [Homo sapiens]                           89   1e-17
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula...    84   3e-16
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula...    79   2e-14
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula...    79   2e-14
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula...    79   2e-14
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula...    79   2e-14
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula...    79   2e-14
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat...    78   2e-14
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat...    78   2e-14
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat...    78   2e-14
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]       78   2e-14
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]    74   5e-13
gi|4502735 cyclin-dependent kinase 4 [Homo sapiens]                    73   1e-12
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [...    72   2e-12
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [...    72   2e-12
gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]       71   3e-12
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]        71   3e-12

>gi|33188449 serine/arginine-rich protein-specific kinase 2 isoform
           a [Homo sapiens]
          Length = 699

 Score = 1446 bits (3742), Expect = 0.0
 Identities = 699/699 (100%), Positives = 699/699 (100%)

Query: 1   MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEI 60
           MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEI
Sbjct: 1   MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEI 60

Query: 61  LGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM 120
           LGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM
Sbjct: 61  LGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAM 120

Query: 121 KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL 180
           KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL
Sbjct: 121 KVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL 180

Query: 181 GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV 240
           GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV
Sbjct: 181 GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV 240

Query: 241 RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQE 300
           RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQE
Sbjct: 241 RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQE 300

Query: 301 IEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQE 360
           IEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQE
Sbjct: 301 IEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQE 360

Query: 361 EKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCP 420
           EKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCP
Sbjct: 361 EKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCP 420

Query: 421 NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS 480
           NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS
Sbjct: 421 NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS 480

Query: 481 VLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIA 540
           VLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIA
Sbjct: 481 VLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIA 540

Query: 541 DLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSG 600
           DLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSG
Sbjct: 541 DLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSG 600

Query: 601 EDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKY 660
           EDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKY
Sbjct: 601 EDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKY 660

Query: 661 GWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 699
           GWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS
Sbjct: 661 GWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 699


>gi|33188447 serine/arginine-rich protein-specific kinase 2 isoform
           b [Homo sapiens]
          Length = 688

 Score = 1401 bits (3626), Expect = 0.0
 Identities = 675/683 (98%), Positives = 679/683 (99%)

Query: 17  KREKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCK 76
           ++    ++PEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCK
Sbjct: 6   EKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCK 65

Query: 77  GGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDE 136
           GGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDE
Sbjct: 66  GGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDE 125

Query: 137 IKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGL 196
           IKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGL
Sbjct: 126 IKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGL 185

Query: 197 PVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAP 256
           PVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAP
Sbjct: 186 PVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAP 245

Query: 257 PPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEEN 316
           PPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEEN
Sbjct: 246 PPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEEN 305

Query: 317 ITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDD 376
           ITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDD
Sbjct: 306 ITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDD 365

Query: 377 VDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDY 436
           VDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDY
Sbjct: 366 VDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDY 425

Query: 437 TYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSP 496
           TYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSP
Sbjct: 426 TYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSP 485

Query: 497 SHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDI 556
           SHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDI
Sbjct: 486 SHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDI 545

Query: 557 QTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIEL 616
           QTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIEL
Sbjct: 546 QTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIEL 605

Query: 617 LGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIP 676
           LGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIP
Sbjct: 606 LGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIP 665

Query: 677 MLEMVPEKRASAGECLRHPWLNS 699
           MLEMVPEKRASAGECLRHPWLNS
Sbjct: 666 MLEMVPEKRASAGECLRHPWLNS 688


>gi|47419936 SFRS protein kinase 1 [Homo sapiens]
          Length = 655

 Score =  781 bits (2017), Expect = 0.0
 Identities = 411/706 (58%), Positives = 500/706 (70%), Gaps = 63/706 (8%)

Query: 4   RKVLAIQARKRRPK--REKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEIL 61
           RKVLA+QARK+R K  ++K  +K E Q +                P  +   PE EEEIL
Sbjct: 3   RKVLALQARKKRTKAKKDKAQRKSETQHRGSA-------------PHSESDLPEQEEEIL 49

Query: 62  GSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMK 121
           GSDD+EQEDP DYCKGGYH VKIGDLFNGRYHVIRKLGWGHFSTVWL WD+QGK+FVAMK
Sbjct: 50  GSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMK 109

Query: 122 VVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLG 181
           VVKSA+HYTETALDEI+LLK VR SDP+DPN++MVVQL+DDFKISG+NG H+CMVFEVLG
Sbjct: 110 VVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLG 169

Query: 182 HHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVR 241
           HHLLKWIIKSNYQGLP+ CVK II+QVLQGLDYLH+KC+IIHTDIKPENIL+ V++ Y+R
Sbjct: 170 HHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIR 229

Query: 242 RMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEI 301
           R+AAEATEWQ++GAPPPSGSAVSTAPQ KP  K+SKNKKKKLKKKQKRQAELLEKR+QEI
Sbjct: 230 RLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEI 289

Query: 302 EELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEE 361
           EE+E+E+             P+  ++ E   E  LK     +  + +  + +   +DQ  
Sbjct: 290 EEMEKES-------GPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTL 342

Query: 362 KEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDED-DDEEDCP 420
                   +E+D +    E+             NG IE    +  Q  ++E    +ED  
Sbjct: 343 --------MERDTEGGAAEI-----------NCNGVIE--VINYTQNSNNETLRHKEDLH 381

Query: 421 NPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGS 480
           N  + ++   N ES +  S      NG+          SQ  +  T + S   + + C S
Sbjct: 382 NANDCDVQNLNQESSFLSSQ-----NGDSST-------SQETDSCTPITSEVSDTMVCQS 429

Query: 481 VLSEGSPLTEQEESSPSHDRSRTVSASS------TGDLP-KAKTRAADLLVNPLDPRNAD 533
             + G   +EQ  S         +           G L  K K+ A + LVNPL+P+NA+
Sbjct: 430 SSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAE 489

Query: 534 KIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDY 593
           K++VKIADLGNACWVHKHFTEDIQTRQYRS+EVLIG+GY+TPADIWSTACMAFELATGDY
Sbjct: 490 KLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDY 549

Query: 594 LFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLF 653
           LFEPHSGE+Y+RDEDHIA IIELLG +PR   ++GKYS+EFF ++G+L+HITKLKPW LF
Sbjct: 550 LFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLF 609

Query: 654 DVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 699
           +VLVEKY W  E+AA FTDFL+PMLE++PEKRA+A ECLRHPWLNS
Sbjct: 610 EVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS 655


>gi|63025196 serine arginine rich protein-specific kinase 3 [Homo
           sapiens]
          Length = 567

 Score =  428 bits (1100), Expect = e-119
 Identities = 197/253 (77%), Positives = 231/253 (91%), Gaps = 1/253 (0%)

Query: 54  PEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQ 113
           P+  + +LGSDDEEQEDP DYCKGGYHPVKIGD+FNGRYHV+RKLGWGHFSTVWLCWD+Q
Sbjct: 41  PQMLQGLLGSDDEEQEDPKDYCKGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQ 100

Query: 114 GKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHV 173
            KRFVA+KVVKSA HYTETA+DEIKLLKCVR+SDPSDP ++ +VQLIDDF+ISG+NG+HV
Sbjct: 101 RKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHV 160

Query: 174 CMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 233
           CMV EVLGH LLKWIIKSNYQGLPV CVKSI+RQVL GLDYLH+KCKIIHTDIKPENIL+
Sbjct: 161 CMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILL 220

Query: 234 CVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQ-KPIGKISKNKKKKLKKKQKRQAE 292
           CV DAY+RR+AAEATEWQ+AGAPPPS S VSTAPQ+    GK+SKNK+KK+++K+K+Q  
Sbjct: 221 CVGDAYIRRLAAEATEWQQAGAPPPSRSIVSTAPQEVLQTGKLSKNKRKKMRRKRKQQKR 280

Query: 293 LLEKRLQEIEELE 305
           LLE+RL++++ LE
Sbjct: 281 LLEERLRDLQRLE 293



 Score =  321 bits (822), Expect = 2e-87
 Identities = 161/235 (68%), Positives = 181/235 (77%), Gaps = 20/235 (8%)

Query: 466 TSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDL--PKAKTRAADLL 523
           TS FSGSL   A  S+LS  S   E                  TG L  P     A++LL
Sbjct: 350 TSGFSGSLFSPASCSILSGSSNQRE------------------TGGLLSPSTPFGASNLL 391

Query: 524 VNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTAC 583
           VNPL+P+NADKI++KIADLGNACWVHKHFTEDIQTRQYR++EVLIGA Y  PADIWSTAC
Sbjct: 392 VNPLEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTAC 451

Query: 584 MAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRH 643
           MAFELATGDYLFEPHSGEDYSRDEDHIAHI+ELLG IP  FALSG+YSREFFNRRGELRH
Sbjct: 452 MAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRH 511

Query: 644 ITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLN 698
           I  LK W L++VL+EKY WP E A QF+ FL+PM+E +PEKRASA +CL+HPWLN
Sbjct: 512 IHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWLN 566


>gi|47717134 CDC-like kinase 2 [Homo sapiens]
          Length = 498

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 59/160 (36%), Positives = 88/160 (55%), Gaps = 11/160 (6%)

Query: 79  YHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWD-MQGKRFVAMKVVKSAQHYTETALDEI 137
           YH   +GD    RY ++  LG G F  V  C D  +G   VA+K++K+ + Y E A  EI
Sbjct: 152 YH---VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEI 208

Query: 138 KLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLP 197
            +L+ + E DP   NK++ VQ+ D F   G    H+C+ FE+LG     ++  +NY   P
Sbjct: 209 NVLEKINEKDPD--NKNLCVQMFDWFDYHG----HMCISFELLGLSTFDFLKDNNYLPYP 262

Query: 198 VRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDD 237
           +  V+ +  Q+ Q + +LH   K+ HTD+KPENIL    D
Sbjct: 263 IHQVRHMAFQLCQAVKFLHDN-KLTHTDLKPENILFVNSD 301



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 51/171 (29%), Positives = 82/171 (47%), Gaps = 8/171 (4%)

Query: 528 DPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFE 587
           D R+     V++ D G+A + H+H +  + TR YR+ EV++  G+S P D+WS  C+ FE
Sbjct: 313 DERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFE 372

Query: 588 LATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKL 647
              G  LF+ H       + +H+A +  +LG IP       +  + F+  R +    T  
Sbjct: 373 YYVGFTLFQTHD------NREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSA 426

Query: 648 KPWSLFDV--LVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPW 696
             +   +   L        E+  Q  D +  MLE  P KR + GE L+HP+
Sbjct: 427 GRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPF 477


>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
          Length = 638

 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 57/158 (36%), Positives = 90/158 (56%), Gaps = 8/158 (5%)

Query: 76  KGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWD-MQGKRFVAMKVVKSAQHYTETAL 134
           K G+   +IGD    RY ++  LG G F  V  C D  +GK  VA+K++++   Y E A 
Sbjct: 288 KEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAAR 347

Query: 135 DEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQ 194
            EI +LK ++E D    NK + V + D F   G    H+C+ FE+LG +  +++ ++N+Q
Sbjct: 348 LEINVLKKIKEKDKE--NKFLCVLMSDWFNFHG----HMCIAFELLGKNTFEFLKENNFQ 401

Query: 195 GLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENIL 232
             P+  V+ +  Q+   L +LH   ++ HTD+KPENIL
Sbjct: 402 PYPLPHVRHMAYQLCHALRFLHEN-QLTHTDLKPENIL 438



 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 49/180 (27%), Positives = 85/180 (47%), Gaps = 26/180 (14%)

Query: 528 DPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFE 587
           + ++     +++AD G+A + H+H T  + TR YR  EV++  G++ P D+WS  C+ FE
Sbjct: 455 EEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFE 514

Query: 588 LATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFF-------NRRGE 640
              G  LF+ H       + +H+  + ++LG IP H     +  + F+           +
Sbjct: 515 YYRGFTLFQTH------ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD 568

Query: 641 LRHITK----LKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPW 696
            R++ +    LK + L D L         +  Q  D +  MLE  P +R +  E L HP+
Sbjct: 569 GRYVKENCKPLKSYMLQDSL---------EHVQLFDLMRRMLEFDPAQRITLAEALLHPF 619


>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
          Length = 490

 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 57/158 (36%), Positives = 90/158 (56%), Gaps = 8/158 (5%)

Query: 76  KGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWD-MQGKRFVAMKVVKSAQHYTETAL 134
           K G+   +IGD    RY ++  LG G F  V  C D  +GK  VA+K++++   Y E A 
Sbjct: 140 KEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAAR 199

Query: 135 DEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQ 194
            EI +LK ++E D    NK + V + D F   G    H+C+ FE+LG +  +++ ++N+Q
Sbjct: 200 LEINVLKKIKEKDKE--NKFLCVLMSDWFNFHG----HMCIAFELLGKNTFEFLKENNFQ 253

Query: 195 GLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENIL 232
             P+  V+ +  Q+   L +LH   ++ HTD+KPENIL
Sbjct: 254 PYPLPHVRHMAYQLCHALRFLHEN-QLTHTDLKPENIL 290



 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 49/180 (27%), Positives = 85/180 (47%), Gaps = 26/180 (14%)

Query: 528 DPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFE 587
           + ++     +++AD G+A + H+H T  + TR YR  EV++  G++ P D+WS  C+ FE
Sbjct: 307 EEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFE 366

Query: 588 LATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFF-------NRRGE 640
              G  LF+ H       + +H+  + ++LG IP H     +  + F+           +
Sbjct: 367 YYRGFTLFQTH------ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD 420

Query: 641 LRHITK----LKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPW 696
            R++ +    LK + L D L         +  Q  D +  MLE  P +R +  E L HP+
Sbjct: 421 GRYVKENCKPLKSYMLQDSL---------EHVQLFDLMRRMLEFDPAQRITLAEALLHPF 471


>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 3 isoform b [Homo sapiens]
          Length = 568

 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 59/174 (33%), Positives = 98/174 (56%), Gaps = 11/174 (6%)

Query: 60  ILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVA 119
           ++G  +    D AD   G Y  V   D    RY V++ +G G F  V   +D + +++VA
Sbjct: 161 VIGGPNNGGYDDAD---GAYIHVP-RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVA 216

Query: 120 MKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEV 179
           +K+V++ + +   A +EI++L+ +++ D +      V+ +++ F        HVCM FE+
Sbjct: 217 LKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN--VIHMLESFTFRN----HVCMAFEL 270

Query: 180 LGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 233
           L   L + I K+ +QG  V+ V+   + +LQ LD LH K KIIH D+KPENIL+
Sbjct: 271 LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH-KNKIIHCDLKPENILL 323



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 64/204 (31%), Positives = 96/204 (47%), Gaps = 23/204 (11%)

Query: 512 LPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAG 571
           L K K    DL    +  ++  +   K+ D G++C+ ++     IQ+R YR+ E+++G+ 
Sbjct: 306 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSR 365

Query: 572 YSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYS 631
           YSTP DIWS  C+  EL TG  LF    GED   + D +A ++ELLG  P       K +
Sbjct: 366 YSTPIDIWSFGCILAELLTGQPLF---PGED---EGDQLACMMELLGMPPPKLLEQSKRA 419

Query: 632 REFFNRRGELRHITKLKPWSLFDVLV-------EKYGWPHE----------DAAQFTDFL 674
           + F N +G  R+ +         VLV       +K G P            D   F +FL
Sbjct: 420 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 479

Query: 675 IPMLEMVPEKRASAGECLRHPWLN 698
              L   P  R +  + LRHPW++
Sbjct: 480 KRCLHWDPSARLTPAQALRHPWIS 503


>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 3 isoform a [Homo sapiens]
          Length = 588

 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 59/174 (33%), Positives = 98/174 (56%), Gaps = 11/174 (6%)

Query: 60  ILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVA 119
           ++G  +    D AD   G Y  V   D    RY V++ +G G F  V   +D + +++VA
Sbjct: 181 VIGGPNNGGYDDAD---GAYIHVP-RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVA 236

Query: 120 MKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEV 179
           +K+V++ + +   A +EI++L+ +++ D +      V+ +++ F        HVCM FE+
Sbjct: 237 LKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN--VIHMLESFTFRN----HVCMAFEL 290

Query: 180 LGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 233
           L   L + I K+ +QG  V+ V+   + +LQ LD LH K KIIH D+KPENIL+
Sbjct: 291 LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH-KNKIIHCDLKPENILL 343



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 64/204 (31%), Positives = 96/204 (47%), Gaps = 23/204 (11%)

Query: 512 LPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAG 571
           L K K    DL    +  ++  +   K+ D G++C+ ++     IQ+R YR+ E+++G+ 
Sbjct: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSR 385

Query: 572 YSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYS 631
           YSTP DIWS  C+  EL TG  LF    GED   + D +A ++ELLG  P       K +
Sbjct: 386 YSTPIDIWSFGCILAELLTGQPLF---PGED---EGDQLACMMELLGMPPPKLLEQSKRA 439

Query: 632 REFFNRRGELRHITKLKPWSLFDVLV-------EKYGWPHE----------DAAQFTDFL 674
           + F N +G  R+ +         VLV       +K G P            D   F +FL
Sbjct: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499

Query: 675 IPMLEMVPEKRASAGECLRHPWLN 698
              L   P  R +  + LRHPW++
Sbjct: 500 KRCLHWDPSARLTPAQALRHPWIS 523


>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
          Length = 526

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 58/175 (33%), Positives = 97/175 (55%), Gaps = 18/175 (10%)

Query: 64  DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQ-GKRFVAMKV 122
           DDEE          G+   + GD+ + RY ++  LG G F  V  C D + G R VA+K+
Sbjct: 185 DDEE----------GHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKI 234

Query: 123 VKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGH 182
           VK+   Y E A  EI++L+ +  +DP+   +   VQ+++ F+  G    H+C+VFE+LG 
Sbjct: 235 VKNVDRYCEAARSEIQVLEHLNTTDPNSTFR--CVQMLEWFEHHG----HICIVFELLGL 288

Query: 183 HLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDD 237
               +I ++ +    +  ++ +  Q+ + +++LHS  K+ HTD+KPENIL    D
Sbjct: 289 STYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSN-KLTHTDLKPENILFVQSD 342



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 49/179 (27%), Positives = 86/179 (48%), Gaps = 20/179 (11%)

Query: 528 DPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFE 587
           D R      +K+ D G+A +  +H +  + TR YR+ EV++  G+S P D+WS  C+  E
Sbjct: 354 DERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIE 413

Query: 588 LATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGEL------ 641
              G  +F  H        ++H+A +  +LG +P+H     +  + F + R +       
Sbjct: 414 YYLGFTVFPTHD------SKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSA 467

Query: 642 -RHIT-KLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLN 698
            R+++ + KP   F +  +     HE   +  D +  MLE  P KR +  E L+HP+ +
Sbjct: 468 GRYVSRRCKPLKEFMLSQDV---EHE---RLFDLIQKMLEYDPAKRITLREALKHPFFD 520


>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
          Length = 484

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 58/175 (33%), Positives = 97/175 (55%), Gaps = 18/175 (10%)

Query: 64  DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQ-GKRFVAMKV 122
           DDEE          G+   + GD+ + RY ++  LG G F  V  C D + G R VA+K+
Sbjct: 143 DDEE----------GHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKI 192

Query: 123 VKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGH 182
           VK+   Y E A  EI++L+ +  +DP+   +   VQ+++ F+  G    H+C+VFE+LG 
Sbjct: 193 VKNVDRYCEAARSEIQVLEHLNTTDPNSTFR--CVQMLEWFEHHG----HICIVFELLGL 246

Query: 183 HLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDD 237
               +I ++ +    +  ++ +  Q+ + +++LHS  K+ HTD+KPENIL    D
Sbjct: 247 STYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSN-KLTHTDLKPENILFVQSD 300



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 49/179 (27%), Positives = 86/179 (48%), Gaps = 20/179 (11%)

Query: 528 DPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFE 587
           D R      +K+ D G+A +  +H +  + TR YR+ EV++  G+S P D+WS  C+  E
Sbjct: 312 DERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIE 371

Query: 588 LATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGEL------ 641
              G  +F  H        ++H+A +  +LG +P+H     +  + F + R +       
Sbjct: 372 YYLGFTVFPTHD------SKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSA 425

Query: 642 -RHIT-KLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLN 698
            R+++ + KP   F +  +     HE   +  D +  MLE  P KR +  E L+HP+ +
Sbjct: 426 GRYVSRRCKPLKEFMLSQDV---EHE---RLFDLIQKMLEYDPAKRITLREALKHPFFD 478


>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
           regulated kinase 2 isoform 2 [Homo sapiens]
          Length = 601

 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 50/143 (34%), Positives = 85/143 (59%), Gaps = 7/143 (4%)

Query: 91  RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSD 150
           RY V++ +G G F  V   +D +  + VA+K+V++ + +   A +EI++L+ +R+ D   
Sbjct: 221 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD- 279

Query: 151 PNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQ 210
            N   V+ ++++F        H+CM FE+L  +L + I K+ +QG  +  V+     +LQ
Sbjct: 280 -NTMNVIHMLENFTFRN----HICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQ 334

Query: 211 GLDYLHSKCKIIHTDIKPENILM 233
            LD LH K +IIH D+KPENIL+
Sbjct: 335 CLDALH-KNRIIHCDLKPENILL 356



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 62/180 (34%), Positives = 89/180 (49%), Gaps = 27/180 (15%)

Query: 537 VKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFE 596
           +K+ D G++C+ H+     IQ+R YR+ EV++GA Y  P D+WS  C+  EL TG  L  
Sbjct: 364 IKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLP 423

Query: 597 PHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRH--ITKLKPWSLFD 654
              GED   + D +A +IELLG   +    + K ++ F + +G  R+  +T L   S+  
Sbjct: 424 ---GED---EGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSV-- 475

Query: 655 VL-------------VEKYGWPHE----DAAQFTDFLIPMLEMVPEKRASAGECLRHPWL 697
           VL              E   W +     D   F DFL   LE  P  R + G+ LRHPWL
Sbjct: 476 VLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 535


>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 2 isoform 1 [Homo sapiens]
          Length = 528

 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 50/143 (34%), Positives = 85/143 (59%), Gaps = 7/143 (4%)

Query: 91  RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSD 150
           RY V++ +G G F  V   +D +  + VA+K+V++ + +   A +EI++L+ +R+ D   
Sbjct: 148 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD- 206

Query: 151 PNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQ 210
            N   V+ ++++F        H+CM FE+L  +L + I K+ +QG  +  V+     +LQ
Sbjct: 207 -NTMNVIHMLENFTFRN----HICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQ 261

Query: 211 GLDYLHSKCKIIHTDIKPENILM 233
            LD LH K +IIH D+KPENIL+
Sbjct: 262 CLDALH-KNRIIHCDLKPENILL 283



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 62/180 (34%), Positives = 89/180 (49%), Gaps = 27/180 (15%)

Query: 537 VKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFE 596
           +K+ D G++C+ H+     IQ+R YR+ EV++GA Y  P D+WS  C+  EL TG  L  
Sbjct: 291 IKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLP 350

Query: 597 PHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRH--ITKLKPWSLFD 654
              GED   + D +A +IELLG   +    + K ++ F + +G  R+  +T L   S+  
Sbjct: 351 ---GED---EGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSV-- 402

Query: 655 VL-------------VEKYGWPHE----DAAQFTDFLIPMLEMVPEKRASAGECLRHPWL 697
           VL              E   W +     D   F DFL   LE  P  R + G+ LRHPWL
Sbjct: 403 VLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 462


>gi|10190706 CDC-like kinase 4 [Homo sapiens]
          Length = 481

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 60/180 (33%), Positives = 96/180 (53%), Gaps = 20/180 (11%)

Query: 64  DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWD--MQGKRFVAMK 121
           DDEE          G+   + GD+   RY ++  LG G F  V  C D  M G   VA+K
Sbjct: 141 DDEE----------GHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMH-VAVK 189

Query: 122 VVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLG 181
           +VK+   Y E A  EI++L+ +  +DP+   +   VQ+++ F   G    HVC+VFE+LG
Sbjct: 190 IVKNVGRYREAARSEIQVLEHLNSTDPNSVFR--CVQMLEWFDHHG----HVCIVFELLG 243

Query: 182 HHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVR 241
                +I ++++    +  ++ +  Q+ Q +++LH   K+ HTD+KPENIL    D  V+
Sbjct: 244 LSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHN-KLTHTDLKPENILFVKSDYVVK 302



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 47/179 (26%), Positives = 86/179 (48%), Gaps = 20/179 (11%)

Query: 528 DPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFE 587
           D R      +K+ D G+A +  +H +  + TR YR+ EV++  G+S P D+WS  C+  E
Sbjct: 310 DERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIE 369

Query: 588 LATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGEL------ 641
              G  +F+ H        ++H+A +  +LG IP+H     +  + F + + +       
Sbjct: 370 YYLGFTVFQTHD------SKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSA 423

Query: 642 -RHI-TKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLN 698
            R++  + KP   F +  +      E+  +  D +  MLE  P +R +  E L+HP+ +
Sbjct: 424 GRYVRRRCKPLKEFMLCHD------EEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFD 476


>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 4 [Homo sapiens]
          Length = 520

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 52/156 (33%), Positives = 85/156 (54%), Gaps = 7/156 (4%)

Query: 78  GYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEI 137
           G++   + D    RY V+  +G G F  V  C D +    VA+K++++ + + + AL E+
Sbjct: 90  GFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMEL 149

Query: 138 KLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLP 197
           K+L+ +R+ D    N   VV + D F        H C+ FE+LG +L + +  +N+QG  
Sbjct: 150 KILEALRKKDKD--NTYNVVHMKDFFYFRN----HFCITFELLGINLYELMKNNNFQGFS 203

Query: 198 VRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 233
           +  V+     VL+ L  L S  KIIH D+KPENI++
Sbjct: 204 LSIVRRFTLSVLKCLQML-SVEKIIHCDLKPENIVL 238



 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 50/162 (30%), Positives = 80/162 (49%), Gaps = 6/162 (3%)

Query: 537 VKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFE 596
           VK+ D G++C+ H+     IQ+R YRS EV++G  Y    D+WS  C+  EL TG  LF 
Sbjct: 246 VKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLF- 304

Query: 597 PHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVL 656
              GE+   + + +A I+E+LG  P  F  +    + FF+ +G  ++IT  +    +   
Sbjct: 305 --PGEN---EVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDS 359

Query: 657 VEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLN 698
            +           F DFL   L   P  R +  + L+H W++
Sbjct: 360 KDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIH 401


>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 5 [Homo sapiens]
          Length = 529

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 50/172 (29%), Positives = 90/172 (52%), Gaps = 13/172 (7%)

Query: 64  DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVV 123
           +D   +D  DY       VK G+ +  RY +   +G G F  V   +D   + +VA+K++
Sbjct: 137 NDGYDDDNYDYI------VKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKII 190

Query: 124 KSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHH 183
           K+ + +   A  E++LL+ + + D     K  +V L   F        H+C+VFE+L ++
Sbjct: 191 KNKKAFLNQAQIEVRLLELMNKHDTE--MKYYIVHLKRHFMFRN----HLCLVFEMLSYN 244

Query: 184 LLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTDIKPENILMC 234
           L   +  +N++G+ +   +   +Q+   L +L + +  IIH D+KPENIL+C
Sbjct: 245 LYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLC 296



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 53/186 (28%), Positives = 86/186 (46%), Gaps = 28/186 (15%)

Query: 531 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 590
           N  +  +KI D G++C + +   + IQ+R YRS EVL+G  Y    D+WS  C+  E+ T
Sbjct: 297 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 356

Query: 591 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGE-LRHITKLKP 649
           G+ LF   SG   + + D +  I+E+LG  P H       +R+FF +  +   ++ K K 
Sbjct: 357 GEPLF---SG---ANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKD 410

Query: 650 W----------SLFDVLVEKYGWPH-----------EDAAQFTDFLIPMLEMVPEKRASA 688
                       L ++L  + G P             D  +F D ++ ML+  P+ R   
Sbjct: 411 GKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQP 470

Query: 689 GECLRH 694
              L+H
Sbjct: 471 YYALQH 476


>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 4 [Homo sapiens]
          Length = 540

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 50/172 (29%), Positives = 90/172 (52%), Gaps = 13/172 (7%)

Query: 64  DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVV 123
           +D   +D  DY       VK G+ +  RY +   +G G F  V   +D   + +VA+K++
Sbjct: 137 NDGYDDDNYDYI------VKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKII 190

Query: 124 KSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHH 183
           K+ + +   A  E++LL+ + + D     K  +V L   F        H+C+VFE+L ++
Sbjct: 191 KNKKAFLNQAQIEVRLLELMNKHDTE--MKYYIVHLKRHFMFRN----HLCLVFEMLSYN 244

Query: 184 LLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTDIKPENILMC 234
           L   +  +N++G+ +   +   +Q+   L +L + +  IIH D+KPENIL+C
Sbjct: 245 LYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLC 296



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 53/186 (28%), Positives = 86/186 (46%), Gaps = 28/186 (15%)

Query: 531 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 590
           N  +  +KI D G++C + +   + IQ+R YRS EVL+G  Y    D+WS  C+  E+ T
Sbjct: 297 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 356

Query: 591 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGE-LRHITKLKP 649
           G+ LF   SG   + + D +  I+E+LG  P H       +R+FF +  +   ++ K K 
Sbjct: 357 GEPLF---SG---ANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKD 410

Query: 650 W----------SLFDVLVEKYGWPH-----------EDAAQFTDFLIPMLEMVPEKRASA 688
                       L ++L  + G P             D  +F D ++ ML+  P+ R   
Sbjct: 411 GKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQP 470

Query: 689 GECLRH 694
              L+H
Sbjct: 471 YYALQH 476


>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 3 [Homo sapiens]
          Length = 584

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 50/172 (29%), Positives = 90/172 (52%), Gaps = 13/172 (7%)

Query: 64  DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVV 123
           +D   +D  DY       VK G+ +  RY +   +G G F  V   +D   + +VA+K++
Sbjct: 137 NDGYDDDNYDYI------VKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKII 190

Query: 124 KSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHH 183
           K+ + +   A  E++LL+ + + D     K  +V L   F        H+C+VFE+L ++
Sbjct: 191 KNKKAFLNQAQIEVRLLELMNKHDTE--MKYYIVHLKRHFMFRN----HLCLVFEMLSYN 244

Query: 184 LLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTDIKPENILMC 234
           L   +  +N++G+ +   +   +Q+   L +L + +  IIH D+KPENIL+C
Sbjct: 245 LYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLC 296



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 53/186 (28%), Positives = 86/186 (46%), Gaps = 28/186 (15%)

Query: 531 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 590
           N  +  +KI D G++C + +   + IQ+R YRS EVL+G  Y    D+WS  C+  E+ T
Sbjct: 297 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 356

Query: 591 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGE-LRHITKLKP 649
           G+ LF   SG   + + D +  I+E+LG  P H       +R+FF +  +   ++ K K 
Sbjct: 357 GEPLF---SG---ANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKD 410

Query: 650 W----------SLFDVLVEKYGWPH-----------EDAAQFTDFLIPMLEMVPEKRASA 688
                       L ++L  + G P             D  +F D ++ ML+  P+ R   
Sbjct: 411 GKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQP 470

Query: 689 GECLRH 694
              L+H
Sbjct: 471 YYALQH 476


>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 2 [Homo sapiens]
          Length = 754

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 50/172 (29%), Positives = 90/172 (52%), Gaps = 13/172 (7%)

Query: 64  DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVV 123
           +D   +D  DY       VK G+ +  RY +   +G G F  V   +D   + +VA+K++
Sbjct: 128 NDGYDDDNYDYI------VKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKII 181

Query: 124 KSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHH 183
           K+ + +   A  E++LL+ + + D     K  +V L   F        H+C+VFE+L ++
Sbjct: 182 KNKKAFLNQAQIEVRLLELMNKHDTE--MKYYIVHLKRHFMFRN----HLCLVFEMLSYN 235

Query: 184 LLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTDIKPENILMC 234
           L   +  +N++G+ +   +   +Q+   L +L + +  IIH D+KPENIL+C
Sbjct: 236 LYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLC 287



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 53/186 (28%), Positives = 86/186 (46%), Gaps = 28/186 (15%)

Query: 531 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 590
           N  +  +KI D G++C + +   + IQ+R YRS EVL+G  Y    D+WS  C+  E+ T
Sbjct: 288 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 347

Query: 591 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGE-LRHITKLKP 649
           G+ LF   SG   + + D +  I+E+LG  P H       +R+FF +  +   ++ K K 
Sbjct: 348 GEPLF---SG---ANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKD 401

Query: 650 W----------SLFDVLVEKYGWPH-----------EDAAQFTDFLIPMLEMVPEKRASA 688
                       L ++L  + G P             D  +F D ++ ML+  P+ R   
Sbjct: 402 GKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQP 461

Query: 689 GECLRH 694
              L+H
Sbjct: 462 YYALQH 467


>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 1 [Homo sapiens]
          Length = 763

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 50/172 (29%), Positives = 90/172 (52%), Gaps = 13/172 (7%)

Query: 64  DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVV 123
           +D   +D  DY       VK G+ +  RY +   +G G F  V   +D   + +VA+K++
Sbjct: 137 NDGYDDDNYDYI------VKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKII 190

Query: 124 KSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHH 183
           K+ + +   A  E++LL+ + + D     K  +V L   F        H+C+VFE+L ++
Sbjct: 191 KNKKAFLNQAQIEVRLLELMNKHDTE--MKYYIVHLKRHFMFRN----HLCLVFEMLSYN 244

Query: 184 LLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTDIKPENILMC 234
           L   +  +N++G+ +   +   +Q+   L +L + +  IIH D+KPENIL+C
Sbjct: 245 LYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLC 296



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 53/186 (28%), Positives = 86/186 (46%), Gaps = 28/186 (15%)

Query: 531 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 590
           N  +  +KI D G++C + +   + IQ+R YRS EVL+G  Y    D+WS  C+  E+ T
Sbjct: 297 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 356

Query: 591 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGE-LRHITKLKP 649
           G+ LF   SG   + + D +  I+E+LG  P H       +R+FF +  +   ++ K K 
Sbjct: 357 GEPLF---SG---ANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKD 410

Query: 650 W----------SLFDVLVEKYGWPH-----------EDAAQFTDFLIPMLEMVPEKRASA 688
                       L ++L  + G P             D  +F D ++ ML+  P+ R   
Sbjct: 411 GKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQP 470

Query: 689 GECLRH 694
              L+H
Sbjct: 471 YYALQH 476


>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform a [Homo sapiens]
          Length = 629

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 51/189 (26%), Positives = 99/189 (52%), Gaps = 19/189 (10%)

Query: 49  PDPTPPEPEEEIL--GSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTV 106
           P  +  + E+++L  G DD+  +          + V+ G+ +  RY +   +G G F  V
Sbjct: 76  PQDSSNKKEKKVLNHGYDDDNHD----------YIVRSGERWLERYEIDSLIGKGSFGQV 125

Query: 107 WLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKIS 166
              +D Q +  VA+K++K+ + +   A  E++LL+ + + D     K  +V L   F   
Sbjct: 126 VKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTE--MKYYIVHLKRHFMFR 183

Query: 167 GMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTD 225
                H+C+VFE+L ++L   +  ++++G+ +   + + +Q+   L +L + +  IIH D
Sbjct: 184 N----HLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCD 239

Query: 226 IKPENILMC 234
           +KPENIL+C
Sbjct: 240 LKPENILLC 248



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 57/186 (30%), Positives = 85/186 (45%), Gaps = 28/186 (15%)

Query: 531 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 590
           N  +  +KI D G++C + +   + IQ+R YRS EVL+G  Y    D+WS  C+  E+ T
Sbjct: 249 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHT 308

Query: 591 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNR----RGELRHITK 646
           G+ LF   SG   S + D +  I+E+LG  P         +R++F R       LR   +
Sbjct: 309 GEPLF---SG---SNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKE 362

Query: 647 LK-------PWSLFDVLVEKYGWP-----------HEDAAQFTDFLIPMLEMVPEKRASA 688
           L+          L +VL  + G P             D  +F D ++ MLE  P  R S 
Sbjct: 363 LRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISP 422

Query: 689 GECLRH 694
              L+H
Sbjct: 423 LGALQH 428


>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform c [Homo sapiens]
          Length = 601

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 51/189 (26%), Positives = 99/189 (52%), Gaps = 19/189 (10%)

Query: 49  PDPTPPEPEEEIL--GSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTV 106
           P  +  + E+++L  G DD+  +          + V+ G+ +  RY +   +G G F  V
Sbjct: 76  PQDSSNKKEKKVLNHGYDDDNHD----------YIVRSGERWLERYEIDSLIGKGSFGQV 125

Query: 107 WLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKIS 166
              +D Q +  VA+K++K+ + +   A  E++LL+ + + D     K  +V L   F   
Sbjct: 126 VKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTE--MKYYIVHLKRHFMFR 183

Query: 167 GMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTD 225
                H+C+VFE+L ++L   +  ++++G+ +   + + +Q+   L +L + +  IIH D
Sbjct: 184 N----HLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCD 239

Query: 226 IKPENILMC 234
           +KPENIL+C
Sbjct: 240 LKPENILLC 248



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 53/168 (31%), Positives = 79/168 (47%), Gaps = 20/168 (11%)

Query: 531 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 590
           N  +  +KI D G++C + +   + IQ+R YRS EVL+G  Y    D+WS  C+  E+ T
Sbjct: 249 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHT 308

Query: 591 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNR----RGELRHITK 646
           G+ LF   SG   S + D +  I+E+LG  P         +R++F R       LR   +
Sbjct: 309 GEPLF---SG---SNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKE 362

Query: 647 LKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRH 694
           L+         + Y  P     Q  D ++ MLE  P  R S    L+H
Sbjct: 363 LR---------KDYQGPGTRRLQ-EDLVLRMLEYEPAARISPLGALQH 400


>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform b [Homo sapiens]
          Length = 589

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 51/189 (26%), Positives = 99/189 (52%), Gaps = 19/189 (10%)

Query: 49  PDPTPPEPEEEIL--GSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTV 106
           P  +  + E+++L  G DD+  +          + V+ G+ +  RY +   +G G F  V
Sbjct: 76  PQDSSNKKEKKVLNHGYDDDNHD----------YIVRSGERWLERYEIDSLIGKGSFGQV 125

Query: 107 WLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKIS 166
              +D Q +  VA+K++K+ + +   A  E++LL+ + + D     K  +V L   F   
Sbjct: 126 VKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTE--MKYYIVHLKRHFMFR 183

Query: 167 GMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTD 225
                H+C+VFE+L ++L   +  ++++G+ +   + + +Q+   L +L + +  IIH D
Sbjct: 184 N----HLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCD 239

Query: 226 IKPENILMC 234
           +KPENIL+C
Sbjct: 240 LKPENILLC 248



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 49/165 (29%), Positives = 74/165 (44%), Gaps = 26/165 (15%)

Query: 531 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 590
           N  +  +KI D G++C + +   + IQ+R YRS EVL+G  Y    D+WS  C+  E+ T
Sbjct: 249 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHT 308

Query: 591 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPW 650
           G+ LF   SG   S + D +  I+E+LG  P         +R++F R             
Sbjct: 309 GEPLF---SG---SNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFER------------- 349

Query: 651 SLFDVLVEKYGWPHEDAAQF-TDFLIPMLEMVPEKRASAGECLRH 694
                 +   GW      +   D ++ MLE  P  R S    L+H
Sbjct: 350 ------LPGGGWTLRRTKELRKDLVLRMLEYEPAARISPLGALQH 388


>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
          Length = 1007

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 53/158 (33%), Positives = 89/158 (56%), Gaps = 9/158 (5%)

Query: 78  GYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWD-MQGKRFVAMKVVKSAQHYTETALDE 136
           GY+ V IG++ + RY+V    G G FS V    D  +  + VA+K++++ +   +T L E
Sbjct: 673 GYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKE 732

Query: 137 IKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQ-G 195
           ++ LK + ++DP D  K   ++L   F     +  H+C+VFE L  +L + + K     G
Sbjct: 733 LEFLKKLNDADPDD--KFHCLRLFRHF----YHKQHLCLVFEPLSMNLREVLKKYGKDVG 786

Query: 196 LPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 233
           L ++ V+S  +Q+   L  L  +C I+H DIKP+NIL+
Sbjct: 787 LHIKAVRSYSQQLFLALKLL-KRCNILHADIKPDNILV 823



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 46/189 (24%), Positives = 82/189 (43%), Gaps = 31/189 (16%)

Query: 531  NADKIRVKIADLGNACWVHKH-FTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELA 589
            N  K  +K+ D G+A  V  +  T  + +R YR+ E++IG  Y    D+WS  C  +EL 
Sbjct: 824  NESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELY 883

Query: 590  TGDYLFEPHSGEDYSRDEDHIAHI-IELLGSIPRHFALSGKYSREFFNR----------- 637
            TG  LF         +  +H+  + ++L G +P      G +  + F++           
Sbjct: 884  TGKILFP-------GKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDK 936

Query: 638  ---RGELRHITKLKPWSLFDVLVEKYGW------PHEDAAQFTDFLIPMLEMVPEKRASA 688
               R ++  ++ + P    D+L +  G         +   Q  D L  +L + P KR S 
Sbjct: 937  VTEREKVTVMSTINPTK--DLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISI 994

Query: 689  GECLRHPWL 697
             + L+H ++
Sbjct: 995  NQALQHAFI 1003


>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
          Length = 616

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 45/142 (31%), Positives = 78/142 (54%), Gaps = 8/142 (5%)

Query: 92  YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDP 151
           Y +I  LG G F  V   W       VA+K++K+  +      +E+KLL C+R  DP + 
Sbjct: 11  YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEA 70

Query: 152 NKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQG 211
           +   V++ ++ F     + +   +VFE+L  +L ++  ++N+  LP R ++++  QVL  
Sbjct: 71  H---VIRFLEFFH----DALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTA 123

Query: 212 LDYLHSKCKIIHTDIKPENILM 233
           L  L  +  IIH D+KPENI++
Sbjct: 124 LARL-KELAIIHADLKPENIML 144



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 34/120 (28%), Positives = 55/120 (45%), Gaps = 12/120 (10%)

Query: 536 RVKIADLGNAC-WVHKHFTED--IQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGD 592
           RVK+ D G+A  +    + ++  IQ+R YR+ E+L+G  +    D+WS  C+  EL  G 
Sbjct: 153 RVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGW 212

Query: 593 YLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSL 652
            L+  ++      + D + +I E  G    H   +   +  FF R     H     PW L
Sbjct: 213 PLYPGNN------EYDQVRYICETQGLPKPHLLHAACKAHHFFKRN---PHPDAANPWQL 263


>gi|4502735 cyclin-dependent kinase 4 [Homo sapiens]
          Length = 303

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 51/150 (34%), Positives = 81/150 (54%), Gaps = 13/150 (8%)

Query: 91  RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK------SAQHYTETALDEIKLLKCVR 144
           RY  + ++G G + TV+   D     FVA+K V+             + + E+ LL+ + 
Sbjct: 5   RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64

Query: 145 ESDPSDPNKDMVVQLIDDFKISGMNG-IHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKS 203
             +   PN   VV+L+D    S  +  I V +VFE +   L  ++ K+   GLP   +K 
Sbjct: 65  AFE--HPN---VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKD 119

Query: 204 IIRQVLQGLDYLHSKCKIIHTDIKPENILM 233
           ++RQ L+GLD+LH+ C I+H D+KPENIL+
Sbjct: 120 LMRQFLRGLDFLHANC-IVHRDLKPENILV 148



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 50/166 (30%), Positives = 74/166 (44%), Gaps = 27/166 (16%)

Query: 537 VKIADLGNACWVHKH---FTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDY 593
           VK+AD G A  ++ +    T  + T  YR+ EVL+ + Y+TP D+WS  C+  E+     
Sbjct: 154 VKLADFGLAR-IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKP 212

Query: 594 LFEPHSGEDYSRDEDHIAHIIELLGSIPR-HFALSGKYSREFFNRRGELRHITKLKPWSL 652
           LF  +S      + D +  I +L+G  P   +       R  F  RG         P  +
Sbjct: 213 LFCGNS------EADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRG---------PRPV 257

Query: 653 FDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLN 698
             V+ E      E  AQ    L+ ML   P KR SA   L+H +L+
Sbjct: 258 QSVVPEM----EESGAQ---LLLEMLTFNPHKRISAFRALQHSYLH 296


>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
           [Homo sapiens]
          Length = 1210

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 43/142 (30%), Positives = 74/142 (52%), Gaps = 8/142 (5%)

Query: 92  YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDP 151
           Y V+  LG G F  V  CW    K  VA+K++K+   Y      E+ +L  +   +  + 
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEY 249

Query: 152 NKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQG 211
           N    V+  + F+       H C+VFE+L  +L  ++ ++ +  LP++ ++ I++QV   
Sbjct: 250 N---FVRSYECFQHKN----HTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATA 302

Query: 212 LDYLHSKCKIIHTDIKPENILM 233
           L  L S   +IH D+KPENI++
Sbjct: 303 LMKLKS-LGLIHADLKPENIML 323



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 35/117 (29%), Positives = 56/117 (47%), Gaps = 11/117 (9%)

Query: 522 LLVNPLDPRNADKIRVKIADLGNACWVHKHFTED-IQTRQYRSIEVLIGAGYSTPADIWS 580
           +LV+P+        RVK+ D G+A  V K      +Q+R YR+ E+++G  +    D+WS
Sbjct: 322 MLVDPV----RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 377

Query: 581 TACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNR 637
             C+  EL  G  L+   S      + D I +I +  G    +   +G  +  FFNR
Sbjct: 378 LGCVIAELFLGWPLYPGAS------EYDQIRYISQTQGLPAEYLLSAGTKTTRFFNR 428


>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
           [Homo sapiens]
          Length = 1075

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 43/142 (30%), Positives = 74/142 (52%), Gaps = 8/142 (5%)

Query: 92  YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDP 151
           Y V+  LG G F  V  CW    K  VA+K++K+   Y      E+ +L  +   +  + 
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEY 249

Query: 152 NKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQG 211
           N    V+  + F+       H C+VFE+L  +L  ++ ++ +  LP++ ++ I++QV   
Sbjct: 250 N---FVRSYECFQHKN----HTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATA 302

Query: 212 LDYLHSKCKIIHTDIKPENILM 233
           L  L S   +IH D+KPENI++
Sbjct: 303 LMKLKS-LGLIHADLKPENIML 323



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 35/117 (29%), Positives = 56/117 (47%), Gaps = 11/117 (9%)

Query: 522 LLVNPLDPRNADKIRVKIADLGNACWVHKHFTED-IQTRQYRSIEVLIGAGYSTPADIWS 580
           +LV+P+        RVK+ D G+A  V K      +Q+R YR+ E+++G  +    D+WS
Sbjct: 322 MLVDPV----RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 377

Query: 581 TACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNR 637
             C+  EL  G  L+   S      + D I +I +  G    +   +G  +  FFNR
Sbjct: 378 LGCVIAELFLGWPLYPGAS------EYDQIRYISQTQGLPAEYLLSAGTKTTRFFNR 428


>gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]
          Length = 1863

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 57/192 (29%), Positives = 98/192 (51%), Gaps = 22/192 (11%)

Query: 53   PPEPEEEILGSDDEEQEDPADYCKGGYH-PVKIGDLFNGRYHVIRKLGWGHFSTVWLCWD 111
            P EP++E+  SDD+E+E   DY     +   K+ D     Y +  +LG G F  V+   +
Sbjct: 1428 PEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDF----YDIEERLGSGKFGQVFRLVE 1483

Query: 112  MQGKRFVAMKVVKS-AQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNG 170
             + ++  A K  K+ +    E    EI ++ C+        +   +VQ +D F+      
Sbjct: 1484 KKTRKVWAGKFFKAYSAKEKENIRQEISIMNCL--------HHPKLVQCVDAFE----EK 1531

Query: 171  IHVCMVFEVL-GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPE 229
             ++ MV E++ G  L + II  +++     C+K  +RQ+ +G++Y+H K  I+H D+KPE
Sbjct: 1532 ANIVMVLEIVSGGELFERIIDEDFELTERECIK-YMRQISEGVEYIH-KQGIVHLDLKPE 1589

Query: 230  NILMCVDDAYVR 241
            NI MCV+    R
Sbjct: 1590 NI-MCVNKTGTR 1600



 Score = 30.0 bits (66), Expect = 7.6
 Identities = 33/123 (26%), Positives = 56/123 (45%), Gaps = 11/123 (8%)

Query: 260  GSAVSTAPQQKPIGK-ISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENIT 318
            G++ +  P++ P  K  + + +  L  K+K  AE      + +     E+ + +     +
Sbjct: 961  GTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPL-----S 1015

Query: 319  SAAPSNDQD--GEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKD-ED 375
            +A PS      G   P   LK  G   A  AET K  G A+  E  + A KE ++KD ++
Sbjct: 1016 NAQPSGPLKPVGNAKPAETLKPMG--NAKPAETLKPMGNAKPDENLKSASKEELKKDVKN 1073

Query: 376  DVD 378
            DV+
Sbjct: 1074 DVN 1076


>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
          Length = 1914

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 57/192 (29%), Positives = 98/192 (51%), Gaps = 22/192 (11%)

Query: 53   PPEPEEEILGSDDEEQEDPADYCKGGYH-PVKIGDLFNGRYHVIRKLGWGHFSTVWLCWD 111
            P EP++E+  SDD+E+E   DY     +   K+ D     Y +  +LG G F  V+   +
Sbjct: 1428 PEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDF----YDIEERLGSGKFGQVFRLVE 1483

Query: 112  MQGKRFVAMKVVKS-AQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNG 170
             + ++  A K  K+ +    E    EI ++ C+        +   +VQ +D F+      
Sbjct: 1484 KKTRKVWAGKFFKAYSAKEKENIRQEISIMNCL--------HHPKLVQCVDAFE----EK 1531

Query: 171  IHVCMVFEVL-GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPE 229
             ++ MV E++ G  L + II  +++     C+K  +RQ+ +G++Y+H K  I+H D+KPE
Sbjct: 1532 ANIVMVLEIVSGGELFERIIDEDFELTERECIK-YMRQISEGVEYIH-KQGIVHLDLKPE 1589

Query: 230  NILMCVDDAYVR 241
            NI MCV+    R
Sbjct: 1590 NI-MCVNKTGTR 1600



 Score = 30.0 bits (66), Expect = 7.6
 Identities = 33/123 (26%), Positives = 56/123 (45%), Gaps = 11/123 (8%)

Query: 260  GSAVSTAPQQKPIGK-ISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENIT 318
            G++ +  P++ P  K  + + +  L  K+K  AE      + +     E+ + +     +
Sbjct: 961  GTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPL-----S 1015

Query: 319  SAAPSNDQD--GEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKD-ED 375
            +A PS      G   P   LK  G   A  AET K  G A+  E  + A KE ++KD ++
Sbjct: 1016 NAQPSGPLKPVGNAKPAETLKPMG--NAKPAETLKPMGNAKPDENLKSASKEELKKDVKN 1073

Query: 376  DVD 378
            DV+
Sbjct: 1074 DVN 1076


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.133    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,001,771
Number of Sequences: 37866
Number of extensions: 2148722
Number of successful extensions: 72527
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1425
Number of HSP's successfully gapped in prelim test: 1256
Number of HSP's that attempted gapping in prelim test: 26769
Number of HSP's gapped (non-prelim): 25357
length of query: 699
length of database: 18,247,518
effective HSP length: 109
effective length of query: 590
effective length of database: 14,120,124
effective search space: 8330873160
effective search space used: 8330873160
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.