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Search of human proteins with 33188447
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33188447 serine/arginine-rich protein-specific kinase 2
isoform b [Homo sapiens]
(688 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33188447 serine/arginine-rich protein-specific kinase 2 isofo... 1422 0.0
gi|33188449 serine/arginine-rich protein-specific kinase 2 isofo... 1401 0.0
gi|47419936 SFRS protein kinase 1 [Homo sapiens] 766 0.0
gi|63025196 serine arginine rich protein-specific kinase 3 [Homo... 428 e-120
gi|47717134 CDC-like kinase 2 [Homo sapiens] 98 2e-20
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 96 8e-20
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] 96 8e-20
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 94 5e-19
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 94 5e-19
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 92 2e-18
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 92 2e-18
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 90 6e-18
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 90 6e-18
gi|10190706 CDC-like kinase 4 [Homo sapiens] 89 1e-17
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 84 3e-16
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 79 2e-14
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 79 2e-14
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 79 2e-14
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 79 2e-14
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 79 2e-14
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 78 2e-14
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 78 2e-14
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 78 2e-14
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 78 2e-14
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] 74 4e-13
gi|4502735 cyclin-dependent kinase 4 [Homo sapiens] 73 1e-12
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 72 2e-12
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 72 2e-12
gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens] 71 3e-12
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens] 71 3e-12
>gi|33188447 serine/arginine-rich protein-specific kinase 2 isoform
b [Homo sapiens]
Length = 688
Score = 1422 bits (3681), Expect = 0.0
Identities = 688/688 (100%), Positives = 688/688 (100%)
Query: 1 MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDP 60
MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDP
Sbjct: 1 MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDP 60
Query: 61 ADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTE 120
ADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTE
Sbjct: 61 ADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTE 120
Query: 121 TALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS 180
TALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS
Sbjct: 121 TALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS 180
Query: 181 NYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQ 240
NYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQ
Sbjct: 181 NYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQ 240
Query: 241 KAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERK 300
KAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERK
Sbjct: 241 KAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERK 300
Query: 301 IIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIE 360
IIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIE
Sbjct: 301 IIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIE 360
Query: 361 KDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPN 420
KDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPN
Sbjct: 361 KDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPN 420
Query: 421 AESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQ 480
AESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQ
Sbjct: 421 AESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQ 480
Query: 481 EESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKH 540
EESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKH
Sbjct: 481 EESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKH 540
Query: 541 FTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIA 600
FTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIA
Sbjct: 541 FTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIA 600
Query: 601 HIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFT 660
HIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFT
Sbjct: 601 HIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFT 660
Query: 661 DFLIPMLEMVPEKRASAGECLRHPWLNS 688
DFLIPMLEMVPEKRASAGECLRHPWLNS
Sbjct: 661 DFLIPMLEMVPEKRASAGECLRHPWLNS 688
>gi|33188449 serine/arginine-rich protein-specific kinase 2 isoform
a [Homo sapiens]
Length = 699
Score = 1401 bits (3626), Expect = 0.0
Identities = 675/683 (98%), Positives = 679/683 (99%)
Query: 6 EKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCK 65
++ ++PEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCK
Sbjct: 17 KREKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCK 76
Query: 66 GGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDE 125
GGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDE
Sbjct: 77 GGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDE 136
Query: 126 IKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGL 185
IKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGL
Sbjct: 137 IKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGL 196
Query: 186 PVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAP 245
PVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAP
Sbjct: 197 PVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAP 256
Query: 246 PPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEEN 305
PPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEEN
Sbjct: 257 PPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEEN 316
Query: 306 ITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDD 365
ITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDD
Sbjct: 317 ITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDD 376
Query: 366 VDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDY 425
VDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDY
Sbjct: 377 VDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDY 436
Query: 426 TYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSP 485
TYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSP
Sbjct: 437 TYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSP 496
Query: 486 SHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDI 545
SHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDI
Sbjct: 497 SHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDI 556
Query: 546 QTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIEL 605
QTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIEL
Sbjct: 557 QTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIEL 616
Query: 606 LGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIP 665
LGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIP
Sbjct: 617 LGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIP 676
Query: 666 MLEMVPEKRASAGECLRHPWLNS 688
MLEMVPEKRASAGECLRHPWLNS
Sbjct: 677 MLEMVPEKRASAGECLRHPWLNS 699
>gi|47419936 SFRS protein kinase 1 [Homo sapiens]
Length = 655
Score = 766 bits (1979), Expect = 0.0
Identities = 395/654 (60%), Positives = 477/654 (72%), Gaps = 48/654 (7%)
Query: 43 PEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQ 102
PE EEEILGSDD+EQEDP DYCKGGYH VKIGDLFNGRYHVIRKLGWGHFSTVWL WD+Q
Sbjct: 42 PEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQ 101
Query: 103 GKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHV 162
GK+FVAMKVVKSA+HYTETALDEI+LLK VR SDP+DPN++MVVQL+DDFKISG+NG H+
Sbjct: 102 GKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHI 161
Query: 163 CMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 222
CMVFEVLGHHLLKWIIKSNYQGLP+ CVK II+QVLQGLDYLH+KC+IIHTDIKPENIL+
Sbjct: 162 CMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL 221
Query: 223 CVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAEL 282
V++ Y+RR+AAEATEWQ++GAPPPSGSAVSTAPQ KP K+SKNKKKKLKKKQKRQAEL
Sbjct: 222 SVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAEL 281
Query: 283 LEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDN 342
LEKR+QEIEE+E+E+ P+ ++ E E LK + + + + +
Sbjct: 282 LEKRMQEIEEMEKES-------GPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESS 334
Query: 343 GEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDED 402
+DQ +E+D + E+ NG IE + Q ++E
Sbjct: 335 TIGQDQTL--------MERDTEGGAAEI-----------NCNGVIE--VINYTQNSNNET 373
Query: 403 -DDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGS 461
+ED N + ++ N ES + S NG+ SQ + T + S
Sbjct: 374 LRHKEDLHNANDCDVQNLNQESSFLSSQ-----NGDSST-------SQETDSCTPITSEV 421
Query: 462 LEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASS------TGDLP-KAKTRAADLLVN 514
+ + C S + G +EQ S + G L K K+ A + LVN
Sbjct: 422 SDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVN 481
Query: 515 PLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMA 574
PL+P+NA+K++VKIADLGNACWVHKHFTEDIQTRQYRS+EVLIG+GY+TPADIWSTACMA
Sbjct: 482 PLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMA 541
Query: 575 FELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHIT 634
FELATGDYLFEPHSGE+Y+RDEDHIA IIELLG +PR ++GKYS+EFF ++G+L+HIT
Sbjct: 542 FELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHIT 601
Query: 635 KLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 688
KLKPW LF+VLVEKY W E+AA FTDFL+PMLE++PEKRA+A ECLRHPWLNS
Sbjct: 602 KLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS 655
>gi|63025196 serine arginine rich protein-specific kinase 3 [Homo
sapiens]
Length = 567
Score = 428 bits (1100), Expect = e-120
Identities = 197/253 (77%), Positives = 231/253 (91%), Gaps = 1/253 (0%)
Query: 43 PEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQ 102
P+ + +LGSDDEEQEDP DYCKGGYHPVKIGD+FNGRYHV+RKLGWGHFSTVWLCWD+Q
Sbjct: 41 PQMLQGLLGSDDEEQEDPKDYCKGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQ 100
Query: 103 GKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHV 162
KRFVA+KVVKSA HYTETA+DEIKLLKCVR+SDPSDP ++ +VQLIDDF+ISG+NG+HV
Sbjct: 101 RKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHV 160
Query: 163 CMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 222
CMV EVLGH LLKWIIKSNYQGLPV CVKSI+RQVL GLDYLH+KCKIIHTDIKPENIL+
Sbjct: 161 CMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILL 220
Query: 223 CVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQ-KPIGKISKNKKKKLKKKQKRQAE 281
CV DAY+RR+AAEATEWQ+AGAPPPS S VSTAPQ+ GK+SKNK+KK+++K+K+Q
Sbjct: 221 CVGDAYIRRLAAEATEWQQAGAPPPSRSIVSTAPQEVLQTGKLSKNKRKKMRRKRKQQKR 280
Query: 282 LLEKRLQEIEELE 294
LLE+RL++++ LE
Sbjct: 281 LLEERLRDLQRLE 293
Score = 321 bits (822), Expect = 2e-87
Identities = 161/235 (68%), Positives = 181/235 (77%), Gaps = 20/235 (8%)
Query: 455 TSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDL--PKAKTRAADLL 512
TS FSGSL A S+LS S E TG L P A++LL
Sbjct: 350 TSGFSGSLFSPASCSILSGSSNQRE------------------TGGLLSPSTPFGASNLL 391
Query: 513 VNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTAC 572
VNPL+P+NADKI++KIADLGNACWVHKHFTEDIQTRQYR++EVLIGA Y PADIWSTAC
Sbjct: 392 VNPLEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTAC 451
Query: 573 MAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRH 632
MAFELATGDYLFEPHSGEDYSRDEDHIAHI+ELLG IP FALSG+YSREFFNRRGELRH
Sbjct: 452 MAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRH 511
Query: 633 ITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLN 687
I LK W L++VL+EKY WP E A QF+ FL+PM+E +PEKRASA +CL+HPWLN
Sbjct: 512 IHNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWLN 566
>gi|47717134 CDC-like kinase 2 [Homo sapiens]
Length = 498
Score = 98.2 bits (243), Expect = 2e-20
Identities = 59/160 (36%), Positives = 88/160 (55%), Gaps = 11/160 (6%)
Query: 68 YHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWD-MQGKRFVAMKVVKSAQHYTETALDEI 126
YH +GD RY ++ LG G F V C D +G VA+K++K+ + Y E A EI
Sbjct: 152 YH---VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEI 208
Query: 127 KLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLP 186
+L+ + E DP NK++ VQ+ D F G H+C+ FE+LG ++ +NY P
Sbjct: 209 NVLEKINEKDPD--NKNLCVQMFDWFDYHG----HMCISFELLGLSTFDFLKDNNYLPYP 262
Query: 187 VRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDD 226
+ V+ + Q+ Q + +LH K+ HTD+KPENIL D
Sbjct: 263 IHQVRHMAFQLCQAVKFLHDN-KLTHTDLKPENILFVNSD 301
Score = 85.5 bits (210), Expect = 1e-16
Identities = 51/171 (29%), Positives = 82/171 (47%), Gaps = 8/171 (4%)
Query: 517 DPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFE 576
D R+ V++ D G+A + H+H + + TR YR+ EV++ G+S P D+WS C+ FE
Sbjct: 313 DERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFE 372
Query: 577 LATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKL 636
G LF+ H + +H+A + +LG IP + + F+ R + T
Sbjct: 373 YYVGFTLFQTHD------NREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSA 426
Query: 637 KPWSLFDV--LVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPW 685
+ + L E+ Q D + MLE P KR + GE L+HP+
Sbjct: 427 GRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPF 477
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 96.3 bits (238), Expect = 8e-20
Identities = 57/158 (36%), Positives = 90/158 (56%), Gaps = 8/158 (5%)
Query: 65 KGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWD-MQGKRFVAMKVVKSAQHYTETAL 123
K G+ +IGD RY ++ LG G F V C D +GK VA+K++++ Y E A
Sbjct: 288 KEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAAR 347
Query: 124 DEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQ 183
EI +LK ++E D NK + V + D F G H+C+ FE+LG + +++ ++N+Q
Sbjct: 348 LEINVLKKIKEKDKE--NKFLCVLMSDWFNFHG----HMCIAFELLGKNTFEFLKENNFQ 401
Query: 184 GLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENIL 221
P+ V+ + Q+ L +LH ++ HTD+KPENIL
Sbjct: 402 PYPLPHVRHMAYQLCHALRFLHEN-QLTHTDLKPENIL 438
Score = 79.7 bits (195), Expect = 8e-15
Identities = 49/180 (27%), Positives = 85/180 (47%), Gaps = 26/180 (14%)
Query: 517 DPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFE 576
+ ++ +++AD G+A + H+H T + TR YR EV++ G++ P D+WS C+ FE
Sbjct: 455 EEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFE 514
Query: 577 LATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFF-------NRRGE 629
G LF+ H + +H+ + ++LG IP H + + F+ +
Sbjct: 515 YYRGFTLFQTH------ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD 568
Query: 630 LRHITK----LKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPW 685
R++ + LK + L D L + Q D + MLE P +R + E L HP+
Sbjct: 569 GRYVKENCKPLKSYMLQDSL---------EHVQLFDLMRRMLEFDPAQRITLAEALLHPF 619
>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
Length = 490
Score = 96.3 bits (238), Expect = 8e-20
Identities = 57/158 (36%), Positives = 90/158 (56%), Gaps = 8/158 (5%)
Query: 65 KGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWD-MQGKRFVAMKVVKSAQHYTETAL 123
K G+ +IGD RY ++ LG G F V C D +GK VA+K++++ Y E A
Sbjct: 140 KEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAAR 199
Query: 124 DEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQ 183
EI +LK ++E D NK + V + D F G H+C+ FE+LG + +++ ++N+Q
Sbjct: 200 LEINVLKKIKEKDKE--NKFLCVLMSDWFNFHG----HMCIAFELLGKNTFEFLKENNFQ 253
Query: 184 GLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENIL 221
P+ V+ + Q+ L +LH ++ HTD+KPENIL
Sbjct: 254 PYPLPHVRHMAYQLCHALRFLHEN-QLTHTDLKPENIL 290
Score = 79.7 bits (195), Expect = 8e-15
Identities = 49/180 (27%), Positives = 85/180 (47%), Gaps = 26/180 (14%)
Query: 517 DPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFE 576
+ ++ +++AD G+A + H+H T + TR YR EV++ G++ P D+WS C+ FE
Sbjct: 307 EEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFE 366
Query: 577 LATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFF-------NRRGE 629
G LF+ H + +H+ + ++LG IP H + + F+ +
Sbjct: 367 YYRGFTLFQTH------ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD 420
Query: 630 LRHITK----LKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPW 685
R++ + LK + L D L + Q D + MLE P +R + E L HP+
Sbjct: 421 GRYVKENCKPLKSYMLQDSL---------EHVQLFDLMRRMLEFDPAQRITLAEALLHPF 471
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 93.6 bits (231), Expect = 5e-19
Identities = 59/174 (33%), Positives = 98/174 (56%), Gaps = 11/174 (6%)
Query: 49 ILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVA 108
++G + D AD G Y V D RY V++ +G G F V +D + +++VA
Sbjct: 161 VIGGPNNGGYDDAD---GAYIHVP-RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVA 216
Query: 109 MKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEV 168
+K+V++ + + A +EI++L+ +++ D + V+ +++ F HVCM FE+
Sbjct: 217 LKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN--VIHMLESFTFRN----HVCMAFEL 270
Query: 169 LGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 222
L L + I K+ +QG V+ V+ + +LQ LD LH K KIIH D+KPENIL+
Sbjct: 271 LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH-KNKIIHCDLKPENILL 323
Score = 85.1 bits (209), Expect = 2e-16
Identities = 64/204 (31%), Positives = 96/204 (47%), Gaps = 23/204 (11%)
Query: 501 LPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAG 560
L K K DL + ++ + K+ D G++C+ ++ IQ+R YR+ E+++G+
Sbjct: 306 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSR 365
Query: 561 YSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYS 620
YSTP DIWS C+ EL TG LF GED + D +A ++ELLG P K +
Sbjct: 366 YSTPIDIWSFGCILAELLTGQPLF---PGED---EGDQLACMMELLGMPPPKLLEQSKRA 419
Query: 621 REFFNRRGELRHITKLKPWSLFDVLV-------EKYGWPHE----------DAAQFTDFL 663
+ F N +G R+ + VLV +K G P D F +FL
Sbjct: 420 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 479
Query: 664 IPMLEMVPEKRASAGECLRHPWLN 687
L P R + + LRHPW++
Sbjct: 480 KRCLHWDPSARLTPAQALRHPWIS 503
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 93.6 bits (231), Expect = 5e-19
Identities = 59/174 (33%), Positives = 98/174 (56%), Gaps = 11/174 (6%)
Query: 49 ILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVA 108
++G + D AD G Y V D RY V++ +G G F V +D + +++VA
Sbjct: 181 VIGGPNNGGYDDAD---GAYIHVP-RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVA 236
Query: 109 MKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEV 168
+K+V++ + + A +EI++L+ +++ D + V+ +++ F HVCM FE+
Sbjct: 237 LKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN--VIHMLESFTFRN----HVCMAFEL 290
Query: 169 LGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 222
L L + I K+ +QG V+ V+ + +LQ LD LH K KIIH D+KPENIL+
Sbjct: 291 LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH-KNKIIHCDLKPENILL 343
Score = 85.1 bits (209), Expect = 2e-16
Identities = 64/204 (31%), Positives = 96/204 (47%), Gaps = 23/204 (11%)
Query: 501 LPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAG 560
L K K DL + ++ + K+ D G++C+ ++ IQ+R YR+ E+++G+
Sbjct: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSR 385
Query: 561 YSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYS 620
YSTP DIWS C+ EL TG LF GED + D +A ++ELLG P K +
Sbjct: 386 YSTPIDIWSFGCILAELLTGQPLF---PGED---EGDQLACMMELLGMPPPKLLEQSKRA 439
Query: 621 REFFNRRGELRHITKLKPWSLFDVLV-------EKYGWPHE----------DAAQFTDFL 663
+ F N +G R+ + VLV +K G P D F +FL
Sbjct: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499
Query: 664 IPMLEMVPEKRASAGECLRHPWLN 687
L P R + + LRHPW++
Sbjct: 500 KRCLHWDPSARLTPAQALRHPWIS 523
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 91.7 bits (226), Expect = 2e-18
Identities = 58/175 (33%), Positives = 97/175 (55%), Gaps = 18/175 (10%)
Query: 53 DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQ-GKRFVAMKV 111
DDEE G+ + GD+ + RY ++ LG G F V C D + G R VA+K+
Sbjct: 185 DDEE----------GHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKI 234
Query: 112 VKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGH 171
VK+ Y E A EI++L+ + +DP+ + VQ+++ F+ G H+C+VFE+LG
Sbjct: 235 VKNVDRYCEAARSEIQVLEHLNTTDPNSTFR--CVQMLEWFEHHG----HICIVFELLGL 288
Query: 172 HLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDD 226
+I ++ + + ++ + Q+ + +++LHS K+ HTD+KPENIL D
Sbjct: 289 STYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSN-KLTHTDLKPENILFVQSD 342
Score = 74.7 bits (182), Expect = 3e-13
Identities = 49/179 (27%), Positives = 86/179 (48%), Gaps = 20/179 (11%)
Query: 517 DPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFE 576
D R +K+ D G+A + +H + + TR YR+ EV++ G+S P D+WS C+ E
Sbjct: 354 DERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIE 413
Query: 577 LATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGEL------ 630
G +F H ++H+A + +LG +P+H + + F + R +
Sbjct: 414 YYLGFTVFPTHD------SKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSA 467
Query: 631 -RHIT-KLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLN 687
R+++ + KP F + + HE + D + MLE P KR + E L+HP+ +
Sbjct: 468 GRYVSRRCKPLKEFMLSQDV---EHE---RLFDLIQKMLEYDPAKRITLREALKHPFFD 520
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 91.7 bits (226), Expect = 2e-18
Identities = 58/175 (33%), Positives = 97/175 (55%), Gaps = 18/175 (10%)
Query: 53 DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQ-GKRFVAMKV 111
DDEE G+ + GD+ + RY ++ LG G F V C D + G R VA+K+
Sbjct: 143 DDEE----------GHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKI 192
Query: 112 VKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGH 171
VK+ Y E A EI++L+ + +DP+ + VQ+++ F+ G H+C+VFE+LG
Sbjct: 193 VKNVDRYCEAARSEIQVLEHLNTTDPNSTFR--CVQMLEWFEHHG----HICIVFELLGL 246
Query: 172 HLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDD 226
+I ++ + + ++ + Q+ + +++LHS K+ HTD+KPENIL D
Sbjct: 247 STYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSN-KLTHTDLKPENILFVQSD 300
Score = 74.7 bits (182), Expect = 3e-13
Identities = 49/179 (27%), Positives = 86/179 (48%), Gaps = 20/179 (11%)
Query: 517 DPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFE 576
D R +K+ D G+A + +H + + TR YR+ EV++ G+S P D+WS C+ E
Sbjct: 312 DERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIE 371
Query: 577 LATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGEL------ 630
G +F H ++H+A + +LG +P+H + + F + R +
Sbjct: 372 YYLGFTVFPTHD------SKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSA 425
Query: 631 -RHIT-KLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLN 687
R+++ + KP F + + HE + D + MLE P KR + E L+HP+ +
Sbjct: 426 GRYVSRRCKPLKEFMLSQDV---EHE---RLFDLIQKMLEYDPAKRITLREALKHPFFD 478
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 90.1 bits (222), Expect = 6e-18
Identities = 50/143 (34%), Positives = 85/143 (59%), Gaps = 7/143 (4%)
Query: 80 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSD 139
RY V++ +G G F V +D + + VA+K+V++ + + A +EI++L+ +R+ D
Sbjct: 221 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD- 279
Query: 140 PNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQ 199
N V+ ++++F H+CM FE+L +L + I K+ +QG + V+ +LQ
Sbjct: 280 -NTMNVIHMLENFTFRN----HICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQ 334
Query: 200 GLDYLHSKCKIIHTDIKPENILM 222
LD LH K +IIH D+KPENIL+
Sbjct: 335 CLDALH-KNRIIHCDLKPENILL 356
Score = 85.1 bits (209), Expect = 2e-16
Identities = 62/180 (34%), Positives = 89/180 (49%), Gaps = 27/180 (15%)
Query: 526 VKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFE 585
+K+ D G++C+ H+ IQ+R YR+ EV++GA Y P D+WS C+ EL TG L
Sbjct: 364 IKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLP 423
Query: 586 PHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRH--ITKLKPWSLFD 643
GED + D +A +IELLG + + K ++ F + +G R+ +T L S+
Sbjct: 424 ---GED---EGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSV-- 475
Query: 644 VL-------------VEKYGWPHE----DAAQFTDFLIPMLEMVPEKRASAGECLRHPWL 686
VL E W + D F DFL LE P R + G+ LRHPWL
Sbjct: 476 VLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 535
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 90.1 bits (222), Expect = 6e-18
Identities = 50/143 (34%), Positives = 85/143 (59%), Gaps = 7/143 (4%)
Query: 80 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSD 139
RY V++ +G G F V +D + + VA+K+V++ + + A +EI++L+ +R+ D
Sbjct: 148 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD- 206
Query: 140 PNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQ 199
N V+ ++++F H+CM FE+L +L + I K+ +QG + V+ +LQ
Sbjct: 207 -NTMNVIHMLENFTFRN----HICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQ 261
Query: 200 GLDYLHSKCKIIHTDIKPENILM 222
LD LH K +IIH D+KPENIL+
Sbjct: 262 CLDALH-KNRIIHCDLKPENILL 283
Score = 85.1 bits (209), Expect = 2e-16
Identities = 62/180 (34%), Positives = 89/180 (49%), Gaps = 27/180 (15%)
Query: 526 VKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFE 585
+K+ D G++C+ H+ IQ+R YR+ EV++GA Y P D+WS C+ EL TG L
Sbjct: 291 IKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLP 350
Query: 586 PHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRH--ITKLKPWSLFD 643
GED + D +A +IELLG + + K ++ F + +G R+ +T L S+
Sbjct: 351 ---GED---EGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSV-- 402
Query: 644 VL-------------VEKYGWPHE----DAAQFTDFLIPMLEMVPEKRASAGECLRHPWL 686
VL E W + D F DFL LE P R + G+ LRHPWL
Sbjct: 403 VLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 462
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 89.0 bits (219), Expect = 1e-17
Identities = 60/180 (33%), Positives = 96/180 (53%), Gaps = 20/180 (11%)
Query: 53 DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWD--MQGKRFVAMK 110
DDEE G+ + GD+ RY ++ LG G F V C D M G VA+K
Sbjct: 141 DDEE----------GHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMH-VAVK 189
Query: 111 VVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLG 170
+VK+ Y E A EI++L+ + +DP+ + VQ+++ F G HVC+VFE+LG
Sbjct: 190 IVKNVGRYREAARSEIQVLEHLNSTDPNSVFR--CVQMLEWFDHHG----HVCIVFELLG 243
Query: 171 HHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVR 230
+I ++++ + ++ + Q+ Q +++LH K+ HTD+KPENIL D V+
Sbjct: 244 LSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHN-KLTHTDLKPENILFVKSDYVVK 302
Score = 75.9 bits (185), Expect = 1e-13
Identities = 47/179 (26%), Positives = 86/179 (48%), Gaps = 20/179 (11%)
Query: 517 DPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFE 576
D R +K+ D G+A + +H + + TR YR+ EV++ G+S P D+WS C+ E
Sbjct: 310 DERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIE 369
Query: 577 LATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGEL------ 630
G +F+ H ++H+A + +LG IP+H + + F + + +
Sbjct: 370 YYLGFTVFQTHD------SKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSA 423
Query: 631 -RHI-TKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLN 687
R++ + KP F + + E+ + D + MLE P +R + E L+HP+ +
Sbjct: 424 GRYVRRRCKPLKEFMLCHD------EEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFD 476
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 84.3 bits (207), Expect = 3e-16
Identities = 52/156 (33%), Positives = 85/156 (54%), Gaps = 7/156 (4%)
Query: 67 GYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEI 126
G++ + D RY V+ +G G F V C D + VA+K++++ + + + AL E+
Sbjct: 90 GFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMEL 149
Query: 127 KLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLP 186
K+L+ +R+ D N VV + D F H C+ FE+LG +L + + +N+QG
Sbjct: 150 KILEALRKKDKD--NTYNVVHMKDFFYFRN----HFCITFELLGINLYELMKNNNFQGFS 203
Query: 187 VRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 222
+ V+ VL+ L L S KIIH D+KPENI++
Sbjct: 204 LSIVRRFTLSVLKCLQML-SVEKIIHCDLKPENIVL 238
Score = 76.3 bits (186), Expect = 9e-14
Identities = 50/162 (30%), Positives = 80/162 (49%), Gaps = 6/162 (3%)
Query: 526 VKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFE 585
VK+ D G++C+ H+ IQ+R YRS EV++G Y D+WS C+ EL TG LF
Sbjct: 246 VKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLF- 304
Query: 586 PHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVL 645
GE+ + + +A I+E+LG P F + + FF+ +G ++IT + +
Sbjct: 305 --PGEN---EVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDS 359
Query: 646 VEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLN 687
+ F DFL L P R + + L+H W++
Sbjct: 360 KDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIH 401
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 78.6 bits (192), Expect = 2e-14
Identities = 50/172 (29%), Positives = 90/172 (52%), Gaps = 13/172 (7%)
Query: 53 DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVV 112
+D +D DY VK G+ + RY + +G G F V +D + +VA+K++
Sbjct: 137 NDGYDDDNYDYI------VKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKII 190
Query: 113 KSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHH 172
K+ + + A E++LL+ + + D K +V L F H+C+VFE+L ++
Sbjct: 191 KNKKAFLNQAQIEVRLLELMNKHDTE--MKYYIVHLKRHFMFRN----HLCLVFEMLSYN 244
Query: 173 LLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTDIKPENILMC 223
L + +N++G+ + + +Q+ L +L + + IIH D+KPENIL+C
Sbjct: 245 LYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLC 296
Score = 69.3 bits (168), Expect = 1e-11
Identities = 53/186 (28%), Positives = 86/186 (46%), Gaps = 28/186 (15%)
Query: 520 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 579
N + +KI D G++C + + + IQ+R YRS EVL+G Y D+WS C+ E+ T
Sbjct: 297 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 356
Query: 580 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGE-LRHITKLKP 638
G+ LF SG + + D + I+E+LG P H +R+FF + + ++ K K
Sbjct: 357 GEPLF---SG---ANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKD 410
Query: 639 W----------SLFDVLVEKYGWPH-----------EDAAQFTDFLIPMLEMVPEKRASA 677
L ++L + G P D +F D ++ ML+ P+ R
Sbjct: 411 GKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQP 470
Query: 678 GECLRH 683
L+H
Sbjct: 471 YYALQH 476
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 78.6 bits (192), Expect = 2e-14
Identities = 50/172 (29%), Positives = 90/172 (52%), Gaps = 13/172 (7%)
Query: 53 DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVV 112
+D +D DY VK G+ + RY + +G G F V +D + +VA+K++
Sbjct: 137 NDGYDDDNYDYI------VKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKII 190
Query: 113 KSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHH 172
K+ + + A E++LL+ + + D K +V L F H+C+VFE+L ++
Sbjct: 191 KNKKAFLNQAQIEVRLLELMNKHDTE--MKYYIVHLKRHFMFRN----HLCLVFEMLSYN 244
Query: 173 LLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTDIKPENILMC 223
L + +N++G+ + + +Q+ L +L + + IIH D+KPENIL+C
Sbjct: 245 LYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLC 296
Score = 69.3 bits (168), Expect = 1e-11
Identities = 53/186 (28%), Positives = 86/186 (46%), Gaps = 28/186 (15%)
Query: 520 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 579
N + +KI D G++C + + + IQ+R YRS EVL+G Y D+WS C+ E+ T
Sbjct: 297 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 356
Query: 580 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGE-LRHITKLKP 638
G+ LF SG + + D + I+E+LG P H +R+FF + + ++ K K
Sbjct: 357 GEPLF---SG---ANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKD 410
Query: 639 W----------SLFDVLVEKYGWPH-----------EDAAQFTDFLIPMLEMVPEKRASA 677
L ++L + G P D +F D ++ ML+ P+ R
Sbjct: 411 GKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQP 470
Query: 678 GECLRH 683
L+H
Sbjct: 471 YYALQH 476
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 78.6 bits (192), Expect = 2e-14
Identities = 50/172 (29%), Positives = 90/172 (52%), Gaps = 13/172 (7%)
Query: 53 DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVV 112
+D +D DY VK G+ + RY + +G G F V +D + +VA+K++
Sbjct: 137 NDGYDDDNYDYI------VKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKII 190
Query: 113 KSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHH 172
K+ + + A E++LL+ + + D K +V L F H+C+VFE+L ++
Sbjct: 191 KNKKAFLNQAQIEVRLLELMNKHDTE--MKYYIVHLKRHFMFRN----HLCLVFEMLSYN 244
Query: 173 LLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTDIKPENILMC 223
L + +N++G+ + + +Q+ L +L + + IIH D+KPENIL+C
Sbjct: 245 LYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLC 296
Score = 69.3 bits (168), Expect = 1e-11
Identities = 53/186 (28%), Positives = 86/186 (46%), Gaps = 28/186 (15%)
Query: 520 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 579
N + +KI D G++C + + + IQ+R YRS EVL+G Y D+WS C+ E+ T
Sbjct: 297 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 356
Query: 580 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGE-LRHITKLKP 638
G+ LF SG + + D + I+E+LG P H +R+FF + + ++ K K
Sbjct: 357 GEPLF---SG---ANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKD 410
Query: 639 W----------SLFDVLVEKYGWPH-----------EDAAQFTDFLIPMLEMVPEKRASA 677
L ++L + G P D +F D ++ ML+ P+ R
Sbjct: 411 GKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQP 470
Query: 678 GECLRH 683
L+H
Sbjct: 471 YYALQH 476
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 78.6 bits (192), Expect = 2e-14
Identities = 50/172 (29%), Positives = 90/172 (52%), Gaps = 13/172 (7%)
Query: 53 DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVV 112
+D +D DY VK G+ + RY + +G G F V +D + +VA+K++
Sbjct: 128 NDGYDDDNYDYI------VKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKII 181
Query: 113 KSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHH 172
K+ + + A E++LL+ + + D K +V L F H+C+VFE+L ++
Sbjct: 182 KNKKAFLNQAQIEVRLLELMNKHDTE--MKYYIVHLKRHFMFRN----HLCLVFEMLSYN 235
Query: 173 LLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTDIKPENILMC 223
L + +N++G+ + + +Q+ L +L + + IIH D+KPENIL+C
Sbjct: 236 LYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLC 287
Score = 69.3 bits (168), Expect = 1e-11
Identities = 53/186 (28%), Positives = 86/186 (46%), Gaps = 28/186 (15%)
Query: 520 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 579
N + +KI D G++C + + + IQ+R YRS EVL+G Y D+WS C+ E+ T
Sbjct: 288 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 347
Query: 580 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGE-LRHITKLKP 638
G+ LF SG + + D + I+E+LG P H +R+FF + + ++ K K
Sbjct: 348 GEPLF---SG---ANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKD 401
Query: 639 W----------SLFDVLVEKYGWPH-----------EDAAQFTDFLIPMLEMVPEKRASA 677
L ++L + G P D +F D ++ ML+ P+ R
Sbjct: 402 GKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQP 461
Query: 678 GECLRH 683
L+H
Sbjct: 462 YYALQH 467
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 78.6 bits (192), Expect = 2e-14
Identities = 50/172 (29%), Positives = 90/172 (52%), Gaps = 13/172 (7%)
Query: 53 DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVV 112
+D +D DY VK G+ + RY + +G G F V +D + +VA+K++
Sbjct: 137 NDGYDDDNYDYI------VKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKII 190
Query: 113 KSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHH 172
K+ + + A E++LL+ + + D K +V L F H+C+VFE+L ++
Sbjct: 191 KNKKAFLNQAQIEVRLLELMNKHDTE--MKYYIVHLKRHFMFRN----HLCLVFEMLSYN 244
Query: 173 LLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTDIKPENILMC 223
L + +N++G+ + + +Q+ L +L + + IIH D+KPENIL+C
Sbjct: 245 LYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLC 296
Score = 69.3 bits (168), Expect = 1e-11
Identities = 53/186 (28%), Positives = 86/186 (46%), Gaps = 28/186 (15%)
Query: 520 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 579
N + +KI D G++C + + + IQ+R YRS EVL+G Y D+WS C+ E+ T
Sbjct: 297 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHT 356
Query: 580 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGE-LRHITKLKP 638
G+ LF SG + + D + I+E+LG P H +R+FF + + ++ K K
Sbjct: 357 GEPLF---SG---ANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKD 410
Query: 639 W----------SLFDVLVEKYGWPH-----------EDAAQFTDFLIPMLEMVPEKRASA 677
L ++L + G P D +F D ++ ML+ P+ R
Sbjct: 411 GKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQP 470
Query: 678 GECLRH 683
L+H
Sbjct: 471 YYALQH 476
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 78.2 bits (191), Expect = 2e-14
Identities = 51/189 (26%), Positives = 99/189 (52%), Gaps = 19/189 (10%)
Query: 38 PDPTPPEPEEEIL--GSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTV 95
P + + E+++L G DD+ + + V+ G+ + RY + +G G F V
Sbjct: 76 PQDSSNKKEKKVLNHGYDDDNHD----------YIVRSGERWLERYEIDSLIGKGSFGQV 125
Query: 96 WLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKIS 155
+D Q + VA+K++K+ + + A E++LL+ + + D K +V L F
Sbjct: 126 VKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTE--MKYYIVHLKRHFMFR 183
Query: 156 GMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTD 214
H+C+VFE+L ++L + ++++G+ + + + +Q+ L +L + + IIH D
Sbjct: 184 N----HLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCD 239
Query: 215 IKPENILMC 223
+KPENIL+C
Sbjct: 240 LKPENILLC 248
Score = 69.7 bits (169), Expect = 8e-12
Identities = 57/186 (30%), Positives = 85/186 (45%), Gaps = 28/186 (15%)
Query: 520 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 579
N + +KI D G++C + + + IQ+R YRS EVL+G Y D+WS C+ E+ T
Sbjct: 249 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHT 308
Query: 580 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNR----RGELRHITK 635
G+ LF SG S + D + I+E+LG P +R++F R LR +
Sbjct: 309 GEPLF---SG---SNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKE 362
Query: 636 LK-------PWSLFDVLVEKYGWP-----------HEDAAQFTDFLIPMLEMVPEKRASA 677
L+ L +VL + G P D +F D ++ MLE P R S
Sbjct: 363 LRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISP 422
Query: 678 GECLRH 683
L+H
Sbjct: 423 LGALQH 428
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 78.2 bits (191), Expect = 2e-14
Identities = 51/189 (26%), Positives = 99/189 (52%), Gaps = 19/189 (10%)
Query: 38 PDPTPPEPEEEIL--GSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTV 95
P + + E+++L G DD+ + + V+ G+ + RY + +G G F V
Sbjct: 76 PQDSSNKKEKKVLNHGYDDDNHD----------YIVRSGERWLERYEIDSLIGKGSFGQV 125
Query: 96 WLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKIS 155
+D Q + VA+K++K+ + + A E++LL+ + + D K +V L F
Sbjct: 126 VKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTE--MKYYIVHLKRHFMFR 183
Query: 156 GMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTD 214
H+C+VFE+L ++L + ++++G+ + + + +Q+ L +L + + IIH D
Sbjct: 184 N----HLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCD 239
Query: 215 IKPENILMC 223
+KPENIL+C
Sbjct: 240 LKPENILLC 248
Score = 68.9 bits (167), Expect = 1e-11
Identities = 53/168 (31%), Positives = 79/168 (47%), Gaps = 20/168 (11%)
Query: 520 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 579
N + +KI D G++C + + + IQ+R YRS EVL+G Y D+WS C+ E+ T
Sbjct: 249 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHT 308
Query: 580 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNR----RGELRHITK 635
G+ LF SG S + D + I+E+LG P +R++F R LR +
Sbjct: 309 GEPLF---SG---SNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKE 362
Query: 636 LKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRH 683
L+ + Y P Q D ++ MLE P R S L+H
Sbjct: 363 LR---------KDYQGPGTRRLQ-EDLVLRMLEYEPAARISPLGALQH 400
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 78.2 bits (191), Expect = 2e-14
Identities = 51/189 (26%), Positives = 99/189 (52%), Gaps = 19/189 (10%)
Query: 38 PDPTPPEPEEEIL--GSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTV 95
P + + E+++L G DD+ + + V+ G+ + RY + +G G F V
Sbjct: 76 PQDSSNKKEKKVLNHGYDDDNHD----------YIVRSGERWLERYEIDSLIGKGSFGQV 125
Query: 96 WLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKIS 155
+D Q + VA+K++K+ + + A E++LL+ + + D K +V L F
Sbjct: 126 VKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTE--MKYYIVHLKRHFMFR 183
Query: 156 GMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTD 214
H+C+VFE+L ++L + ++++G+ + + + +Q+ L +L + + IIH D
Sbjct: 184 N----HLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCD 239
Query: 215 IKPENILMC 223
+KPENIL+C
Sbjct: 240 LKPENILLC 248
Score = 67.0 bits (162), Expect = 5e-11
Identities = 49/165 (29%), Positives = 74/165 (44%), Gaps = 26/165 (15%)
Query: 520 NADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELAT 579
N + +KI D G++C + + + IQ+R YRS EVL+G Y D+WS C+ E+ T
Sbjct: 249 NPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHT 308
Query: 580 GDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPW 639
G+ LF SG S + D + I+E+LG P +R++F R
Sbjct: 309 GEPLF---SG---SNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFER------------- 349
Query: 640 SLFDVLVEKYGWPHEDAAQF-TDFLIPMLEMVPEKRASAGECLRH 683
+ GW + D ++ MLE P R S L+H
Sbjct: 350 ------LPGGGWTLRRTKELRKDLVLRMLEYEPAARISPLGALQH 388
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 78.2 bits (191), Expect = 2e-14
Identities = 53/158 (33%), Positives = 89/158 (56%), Gaps = 9/158 (5%)
Query: 67 GYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWD-MQGKRFVAMKVVKSAQHYTETALDE 125
GY+ V IG++ + RY+V G G FS V D + + VA+K++++ + +T L E
Sbjct: 673 GYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKE 732
Query: 126 IKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQ-G 184
++ LK + ++DP D K ++L F + H+C+VFE L +L + + K G
Sbjct: 733 LEFLKKLNDADPDD--KFHCLRLFRHF----YHKQHLCLVFEPLSMNLREVLKKYGKDVG 786
Query: 185 LPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 222
L ++ V+S +Q+ L L +C I+H DIKP+NIL+
Sbjct: 787 LHIKAVRSYSQQLFLALKLL-KRCNILHADIKPDNILV 823
Score = 55.5 bits (132), Expect = 2e-07
Identities = 46/189 (24%), Positives = 82/189 (43%), Gaps = 31/189 (16%)
Query: 520 NADKIRVKIADLGNACWVHKH-FTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELA 578
N K +K+ D G+A V + T + +R YR+ E++IG Y D+WS C +EL
Sbjct: 824 NESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELY 883
Query: 579 TGDYLFEPHSGEDYSRDEDHIAHI-IELLGSIPRHFALSGKYSREFFNR----------- 626
TG LF + +H+ + ++L G +P G + + F++
Sbjct: 884 TGKILFP-------GKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDK 936
Query: 627 ---RGELRHITKLKPWSLFDVLVEKYGW------PHEDAAQFTDFLIPMLEMVPEKRASA 677
R ++ ++ + P D+L + G + Q D L +L + P KR S
Sbjct: 937 VTEREKVTVMSTINPTK--DLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISI 994
Query: 678 GECLRHPWL 686
+ L+H ++
Sbjct: 995 NQALQHAFI 1003
>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
Length = 616
Score = 73.9 bits (180), Expect = 4e-13
Identities = 45/142 (31%), Positives = 78/142 (54%), Gaps = 8/142 (5%)
Query: 81 YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDP 140
Y +I LG G F V W VA+K++K+ + +E+KLL C+R DP +
Sbjct: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEA 70
Query: 141 NKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQG 200
+ V++ ++ F + + +VFE+L +L ++ ++N+ LP R ++++ QVL
Sbjct: 71 H---VIRFLEFFH----DALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTA 123
Query: 201 LDYLHSKCKIIHTDIKPENILM 222
L L + IIH D+KPENI++
Sbjct: 124 LARL-KELAIIHADLKPENIML 144
Score = 47.8 bits (112), Expect = 3e-05
Identities = 34/120 (28%), Positives = 55/120 (45%), Gaps = 12/120 (10%)
Query: 525 RVKIADLGNAC-WVHKHFTED--IQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGD 581
RVK+ D G+A + + ++ IQ+R YR+ E+L+G + D+WS C+ EL G
Sbjct: 153 RVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGW 212
Query: 582 YLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSL 641
L+ ++ + D + +I E G H + + FF R H PW L
Sbjct: 213 PLYPGNN------EYDQVRYICETQGLPKPHLLHAACKAHHFFKRN---PHPDAANPWQL 263
>gi|4502735 cyclin-dependent kinase 4 [Homo sapiens]
Length = 303
Score = 72.8 bits (177), Expect = 1e-12
Identities = 51/150 (34%), Positives = 81/150 (54%), Gaps = 13/150 (8%)
Query: 80 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK------SAQHYTETALDEIKLLKCVR 133
RY + ++G G + TV+ D FVA+K V+ + + E+ LL+ +
Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64
Query: 134 ESDPSDPNKDMVVQLIDDFKISGMNG-IHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKS 192
+ PN VV+L+D S + I V +VFE + L ++ K+ GLP +K
Sbjct: 65 AFE--HPN---VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKD 119
Query: 193 IIRQVLQGLDYLHSKCKIIHTDIKPENILM 222
++RQ L+GLD+LH+ C I+H D+KPENIL+
Sbjct: 120 LMRQFLRGLDFLHANC-IVHRDLKPENILV 148
Score = 48.5 bits (114), Expect = 2e-05
Identities = 50/166 (30%), Positives = 74/166 (44%), Gaps = 27/166 (16%)
Query: 526 VKIADLGNACWVHKH---FTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDY 582
VK+AD G A ++ + T + T YR+ EVL+ + Y+TP D+WS C+ E+
Sbjct: 154 VKLADFGLAR-IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKP 212
Query: 583 LFEPHSGEDYSRDEDHIAHIIELLGSIPR-HFALSGKYSREFFNRRGELRHITKLKPWSL 641
LF +S + D + I +L+G P + R F RG P +
Sbjct: 213 LFCGNS------EADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRG---------PRPV 257
Query: 642 FDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLN 687
V+ E E AQ L+ ML P KR SA L+H +L+
Sbjct: 258 QSVVPEM----EESGAQ---LLLEMLTFNPHKRISAFRALQHSYLH 296
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
[Homo sapiens]
Length = 1210
Score = 72.0 bits (175), Expect = 2e-12
Identities = 43/142 (30%), Positives = 74/142 (52%), Gaps = 8/142 (5%)
Query: 81 YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDP 140
Y V+ LG G F V CW K VA+K++K+ Y E+ +L + + +
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEY 249
Query: 141 NKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQG 200
N V+ + F+ H C+VFE+L +L ++ ++ + LP++ ++ I++QV
Sbjct: 250 N---FVRSYECFQHKN----HTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATA 302
Query: 201 LDYLHSKCKIIHTDIKPENILM 222
L L S +IH D+KPENI++
Sbjct: 303 LMKLKS-LGLIHADLKPENIML 323
Score = 50.1 bits (118), Expect = 7e-06
Identities = 35/117 (29%), Positives = 56/117 (47%), Gaps = 11/117 (9%)
Query: 511 LLVNPLDPRNADKIRVKIADLGNACWVHKHFTED-IQTRQYRSIEVLIGAGYSTPADIWS 569
+LV+P+ RVK+ D G+A V K +Q+R YR+ E+++G + D+WS
Sbjct: 322 MLVDPV----RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 377
Query: 570 TACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNR 626
C+ EL G L+ S + D I +I + G + +G + FFNR
Sbjct: 378 LGCVIAELFLGWPLYPGAS------EYDQIRYISQTQGLPAEYLLSAGTKTTRFFNR 428
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
[Homo sapiens]
Length = 1075
Score = 72.0 bits (175), Expect = 2e-12
Identities = 43/142 (30%), Positives = 74/142 (52%), Gaps = 8/142 (5%)
Query: 81 YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDP 140
Y V+ LG G F V CW K VA+K++K+ Y E+ +L + + +
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEY 249
Query: 141 NKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQG 200
N V+ + F+ H C+VFE+L +L ++ ++ + LP++ ++ I++QV
Sbjct: 250 N---FVRSYECFQHKN----HTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATA 302
Query: 201 LDYLHSKCKIIHTDIKPENILM 222
L L S +IH D+KPENI++
Sbjct: 303 LMKLKS-LGLIHADLKPENIML 323
Score = 50.1 bits (118), Expect = 7e-06
Identities = 35/117 (29%), Positives = 56/117 (47%), Gaps = 11/117 (9%)
Query: 511 LLVNPLDPRNADKIRVKIADLGNACWVHKHFTED-IQTRQYRSIEVLIGAGYSTPADIWS 569
+LV+P+ RVK+ D G+A V K +Q+R YR+ E+++G + D+WS
Sbjct: 322 MLVDPV----RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 377
Query: 570 TACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNR 626
C+ EL G L+ S + D I +I + G + +G + FFNR
Sbjct: 378 LGCVIAELFLGWPLYPGAS------EYDQIRYISQTQGLPAEYLLSAGTKTTRFFNR 428
>gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]
Length = 1863
Score = 71.2 bits (173), Expect = 3e-12
Identities = 57/192 (29%), Positives = 98/192 (51%), Gaps = 22/192 (11%)
Query: 42 PPEPEEEILGSDDEEQEDPADYCKGGYH-PVKIGDLFNGRYHVIRKLGWGHFSTVWLCWD 100
P EP++E+ SDD+E+E DY + K+ D Y + +LG G F V+ +
Sbjct: 1428 PEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDF----YDIEERLGSGKFGQVFRLVE 1483
Query: 101 MQGKRFVAMKVVKS-AQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNG 159
+ ++ A K K+ + E EI ++ C+ + +VQ +D F+
Sbjct: 1484 KKTRKVWAGKFFKAYSAKEKENIRQEISIMNCL--------HHPKLVQCVDAFE----EK 1531
Query: 160 IHVCMVFEVL-GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPE 218
++ MV E++ G L + II +++ C+K +RQ+ +G++Y+H K I+H D+KPE
Sbjct: 1532 ANIVMVLEIVSGGELFERIIDEDFELTERECIK-YMRQISEGVEYIH-KQGIVHLDLKPE 1589
Query: 219 NILMCVDDAYVR 230
NI MCV+ R
Sbjct: 1590 NI-MCVNKTGTR 1600
Score = 30.0 bits (66), Expect = 7.5
Identities = 33/123 (26%), Positives = 56/123 (45%), Gaps = 11/123 (8%)
Query: 249 GSAVSTAPQQKPIGK-ISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENIT 307
G++ + P++ P K + + + L K+K AE + + E+ + + +
Sbjct: 961 GTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPL-----S 1015
Query: 308 SAAPSNDQD--GEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKD-ED 364
+A PS G P LK G A AET K G A+ E + A KE ++KD ++
Sbjct: 1016 NAQPSGPLKPVGNAKPAETLKPMG--NAKPAETLKPMGNAKPDENLKSASKEELKKDVKN 1073
Query: 365 DVD 367
DV+
Sbjct: 1074 DVN 1076
>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
Length = 1914
Score = 71.2 bits (173), Expect = 3e-12
Identities = 57/192 (29%), Positives = 98/192 (51%), Gaps = 22/192 (11%)
Query: 42 PPEPEEEILGSDDEEQEDPADYCKGGYH-PVKIGDLFNGRYHVIRKLGWGHFSTVWLCWD 100
P EP++E+ SDD+E+E DY + K+ D Y + +LG G F V+ +
Sbjct: 1428 PEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDF----YDIEERLGSGKFGQVFRLVE 1483
Query: 101 MQGKRFVAMKVVKS-AQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNG 159
+ ++ A K K+ + E EI ++ C+ + +VQ +D F+
Sbjct: 1484 KKTRKVWAGKFFKAYSAKEKENIRQEISIMNCL--------HHPKLVQCVDAFE----EK 1531
Query: 160 IHVCMVFEVL-GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPE 218
++ MV E++ G L + II +++ C+K +RQ+ +G++Y+H K I+H D+KPE
Sbjct: 1532 ANIVMVLEIVSGGELFERIIDEDFELTERECIK-YMRQISEGVEYIH-KQGIVHLDLKPE 1589
Query: 219 NILMCVDDAYVR 230
NI MCV+ R
Sbjct: 1590 NI-MCVNKTGTR 1600
Score = 30.0 bits (66), Expect = 7.5
Identities = 33/123 (26%), Positives = 56/123 (45%), Gaps = 11/123 (8%)
Query: 249 GSAVSTAPQQKPIGK-ISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENIT 307
G++ + P++ P K + + + L K+K AE + + E+ + + +
Sbjct: 961 GTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPL-----S 1015
Query: 308 SAAPSNDQD--GEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKD-ED 364
+A PS G P LK G A AET K G A+ E + A KE ++KD ++
Sbjct: 1016 NAQPSGPLKPVGNAKPAETLKPMG--NAKPAETLKPMGNAKPDENLKSASKEELKKDVKN 1073
Query: 365 DVD 367
DV+
Sbjct: 1074 DVN 1076
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.132 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,409,616
Number of Sequences: 37866
Number of extensions: 2072667
Number of successful extensions: 70429
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1355
Number of HSP's successfully gapped in prelim test: 1233
Number of HSP's that attempted gapping in prelim test: 27038
Number of HSP's gapped (non-prelim): 24892
length of query: 688
length of database: 18,247,518
effective HSP length: 109
effective length of query: 579
effective length of database: 14,120,124
effective search space: 8175551796
effective search space used: 8175551796
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.