Search of human proteins with 32481206

Search of human proteins with 32481206

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32481206 lactase-phlorizin hydrolase preproprotein [Homo
sapiens]
         (1927 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32481206 lactase-phlorizin hydrolase preproprotein [Homo sapi...  3991   0.0  
gi|24497614 klotho [Homo sapiens]                                     652   0.0  
gi|28376633 klotho beta [Homo sapiens]                                638   0.0  
gi|110681710 lactase-like [Homo sapiens]                              483   e-136
gi|13273313 cytosolic beta-glucosidase isoform a [Homo sapiens]       454   e-127
gi|190360571 cytosolic beta-glucosidase isoform b [Homo sapiens]      119   4e-26
gi|148886707 hephaestin-like 1 [Homo sapiens]                          40   0.017
gi|33350932 cytoplasmic dynein 1 heavy chain 1 [Homo sapiens]          34   1.6  
gi|16905507 progressive ankylosis protein [Homo sapiens]               34   1.6  
gi|169658367 BAH domain and coiled-coil containing 1 [Homo sapiens]    32   7.8  

>gi|32481206 lactase-phlorizin hydrolase preproprotein [Homo sapiens]
          Length = 1927

 Score = 3991 bits (10351), Expect = 0.0
 Identities = 1927/1927 (100%), Positives = 1927/1927 (100%)

Query: 1    MELSWHVVFIALLSFSCWGSDWESDRNFISTAGPLTNDLLHNLSGLLGDQSSNFVAGDKD 60
            MELSWHVVFIALLSFSCWGSDWESDRNFISTAGPLTNDLLHNLSGLLGDQSSNFVAGDKD
Sbjct: 1    MELSWHVVFIALLSFSCWGSDWESDRNFISTAGPLTNDLLHNLSGLLGDQSSNFVAGDKD 60

Query: 61   MYVCHQPLPTFLPEYFSSLHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKAL 120
            MYVCHQPLPTFLPEYFSSLHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKAL
Sbjct: 61   MYVCHQPLPTFLPEYFSSLHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKAL 120

Query: 121  KTARLQPMVILHHQTLPASTLRRTEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIK 180
            KTARLQPMVILHHQTLPASTLRRTEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIK
Sbjct: 121  KTARLQPMVILHHQTLPASTLRRTEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIK 180

Query: 181  ELPHQESRASQLQTLSDAHRKAYEIYHESYAFQGGKLSVVLRAEDIPELLLEPPISALAQ 240
            ELPHQESRASQLQTLSDAHRKAYEIYHESYAFQGGKLSVVLRAEDIPELLLEPPISALAQ
Sbjct: 181  ELPHQESRASQLQTLSDAHRKAYEIYHESYAFQGGKLSVVLRAEDIPELLLEPPISALAQ 240

Query: 241  DTVDFLSLDLSYECQNEASLRQKLSKLQTIEPKVKVFIFNLKLPDCPSTMKNPASLLFSL 300
            DTVDFLSLDLSYECQNEASLRQKLSKLQTIEPKVKVFIFNLKLPDCPSTMKNPASLLFSL
Sbjct: 241  DTVDFLSLDLSYECQNEASLRQKLSKLQTIEPKVKVFIFNLKLPDCPSTMKNPASLLFSL 300

Query: 301  FEAINKDQVLTIGFDINEFLSCSSSSKKSMSCSLTGSLALQPDQQQDHETTDSSPASAYQ 360
            FEAINKDQVLTIGFDINEFLSCSSSSKKSMSCSLTGSLALQPDQQQDHETTDSSPASAYQ
Sbjct: 301  FEAINKDQVLTIGFDINEFLSCSSSSKKSMSCSLTGSLALQPDQQQDHETTDSSPASAYQ 360

Query: 361  RIWEAFANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAEGGRGVSIWDPRRPLNTT 420
            RIWEAFANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAEGGRGVSIWDPRRPLNTT
Sbjct: 361  RIWEAFANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAEGGRGVSIWDPRRPLNTT 420

Query: 421  EGQATLEVASDSYHKVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKL 480
            EGQATLEVASDSYHKVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKL
Sbjct: 421  EGQATLEVASDSYHKVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKL 480

Query: 481  IDRLQDAGIEPMATLFHWDLPQALQDHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTF 540
            IDRLQDAGIEPMATLFHWDLPQALQDHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTF
Sbjct: 481  IDRLQDAGIEPMATLFHWDLPQALQDHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTF 540

Query: 541  HEPWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIV 600
            HEPWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIV
Sbjct: 541  HEPWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIV 600

Query: 601  LNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQMNRQCSHPV 660
            LNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQMNRQCSHPV
Sbjct: 601  LNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQMNRQCSHPV 660

Query: 661  AQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQHVNHVWPQT 720
            AQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQHVNHVWPQT
Sbjct: 661  AQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQHVNHVWPQT 720

Query: 721  SSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYIN 780
            SSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYIN
Sbjct: 721  SSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYIN 780

Query: 781  EVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTS 840
            EVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTS
Sbjct: 781  EVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTS 840

Query: 841  IIEKNGFLTKGAKRLLPPNTVNLPSKVRAFTFPSEVPSKAKVVWEKFSSQPKFERDLFYH 900
            IIEKNGFLTKGAKRLLPPNTVNLPSKVRAFTFPSEVPSKAKVVWEKFSSQPKFERDLFYH
Sbjct: 841  IIEKNGFLTKGAKRLLPPNTVNLPSKVRAFTFPSEVPSKAKVVWEKFSSQPKFERDLFYH 900

Query: 901  GTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLD 960
            GTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLD
Sbjct: 901  GTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLD 960

Query: 961  ADLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFH 1020
            ADLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFH
Sbjct: 961  ADLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFH 1020

Query: 1021 WDLPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFP 1080
            WDLPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFP
Sbjct: 1021 WDLPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFP 1080

Query: 1081 PGVKDPGWAPYRIAHAVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDV 1140
            PGVKDPGWAPYRIAHAVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDV
Sbjct: 1081 PGVKDPGWAPYRIAHAVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDV 1140

Query: 1141 EAADRMLQFSLGWFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRAT 1200
            EAADRMLQFSLGWFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRAT
Sbjct: 1141 EAADRMLQFSLGWFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRAT 1200

Query: 1201 ADVFCLNTYYSRIVQHKTPRLNPPSYEDDQEMAEEEDPSWPSTAMNRAAPWGTRRLLNWI 1260
            ADVFCLNTYYSRIVQHKTPRLNPPSYEDDQEMAEEEDPSWPSTAMNRAAPWGTRRLLNWI
Sbjct: 1201 ADVFCLNTYYSRIVQHKTPRLNPPSYEDDQEMAEEEDPSWPSTAMNRAAPWGTRRLLNWI 1260

Query: 1261 KEEYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWSLMD 1320
            KEEYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWSLMD
Sbjct: 1261 KEEYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWSLMD 1320

Query: 1321 NFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMPLAREDEFLYGRFPEG 1380
            NFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMPLAREDEFLYGRFPEG
Sbjct: 1321 NFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMPLAREDEFLYGRFPEG 1380

Query: 1381 FIWSAASAAYQIEGAWRADGKGLSIWDTFSHTPLRVENDAIGDVACDSYHKIAEDLVTLQ 1440
            FIWSAASAAYQIEGAWRADGKGLSIWDTFSHTPLRVENDAIGDVACDSYHKIAEDLVTLQ
Sbjct: 1381 FIWSAASAAYQIEGAWRADGKGLSIWDTFSHTPLRVENDAIGDVACDSYHKIAEDLVTLQ 1440

Query: 1441 NLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHWDLPQTL 1500
            NLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHWDLPQTL
Sbjct: 1441 NLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHWDLPQTL 1500

Query: 1501 QDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAPGVSNRP 1560
            QDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAPGVSNRP
Sbjct: 1501 QDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAPGVSNRP 1560

Query: 1561 GTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDVEAARRY 1620
            GTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDVEAARRY
Sbjct: 1561 GTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDVEAARRY 1620

Query: 1621 VQFMGGWFAHPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGF 1680
            VQFMGGWFAHPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGF
Sbjct: 1621 VQFMGGWFAHPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGF 1680

Query: 1681 NHYTTVLAYNLNYATAISSFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEY 1740
            NHYTTVLAYNLNYATAISSFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEY
Sbjct: 1681 NHYTTVLAYNLNYATAISSFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEY 1740

Query: 1741 NDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEW 1800
            NDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEW
Sbjct: 1741 NDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEW 1800

Query: 1801 ATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPDPATGPHACLHQPDAGPTI 1860
            ATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPDPATGPHACLHQPDAGPTI
Sbjct: 1801 ATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPDPATGPHACLHQPDAGPTI 1860

Query: 1861 SPVRQEEVQFLGLMLGTTEAQTALYVLFSLVLLGVCGLAFLSYKYCKRSKQGKTQRSQQE 1920
            SPVRQEEVQFLGLMLGTTEAQTALYVLFSLVLLGVCGLAFLSYKYCKRSKQGKTQRSQQE
Sbjct: 1861 SPVRQEEVQFLGLMLGTTEAQTALYVLFSLVLLGVCGLAFLSYKYCKRSKQGKTQRSQQE 1920

Query: 1921 LSPVSSF 1927
            LSPVSSF
Sbjct: 1921 LSPVSSF 1927


>gi|24497614 klotho [Homo sapiens]
          Length = 1012

 Score =  652 bits (1683), Expect = 0.0
 Identities = 375/1002 (37%), Positives = 530/1002 (52%), Gaps = 101/1002 (10%)

Query: 877  PSKAKVVWEKFSSQPKFERDLFYHGTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFT 936
            P      W +FS  P  E    + GTF D FLW V S+AYQ EG W   GKG SIWD FT
Sbjct: 35   PGDGAQTWARFSRPPAPEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFT 94

Query: 937  HTPGSNVKDN---------------ATGDIACDSYHQLDADLNMLRALKVKAYRFSISWS 981
            H P +   D+               ATGD+A DSY+ +  D   LR L V  YRFSISW+
Sbjct: 95   HHPLAPPGDSRNASLPLGAPSPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFSISWA 154

Query: 982  RIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFHWDLPQALQDI-GGWENPALID 1040
            R+ P G     N  G+ YY RL+  L    + P+VTL+HWDLPQ LQD  GGW N AL D
Sbjct: 155  RVLPNGSAGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDAYGGWANRALAD 214

Query: 1041 LFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFPPGVKDPGWAPYRIAHAVIKA 1100
             F  YA+ CF+ FG +VK+W+T + P  +AW GY +G   PG++      Y +AH ++ A
Sbjct: 215  HFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLA 274

Query: 1101 HARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDVEAADRMLQFSLGWFAHPIFR 1160
            HA+V+H Y+  +R  Q G +S++LS+HW  P+       ++   + L F LGWFA P+F 
Sbjct: 275  HAKVWHLYNTSFRPTQGGQVSIALSSHWINPRRM-TDHSIKECQKSLDFVLGWFAKPVFI 333

Query: 1161 NGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRATADVFCLNTYYSRIVQHKTPR 1220
            +GDYP++MK          +  +S LP FTE EK+FI+ TAD F L            P 
Sbjct: 334  DGDYPESMK----------NNLSSILPDFTESEKKFIKGTADFFALCF---------GPT 374

Query: 1221 LNPPSYEDDQEMAEEEDPSWPSTAMNRAAPWGTRRLLNWIKEEYGDIPIYITENGVGLT- 1279
            L+    +   +  + E P+              R+LL+WI  E+    I+I ENG  ++ 
Sbjct: 375  LSFQLLDPHMKFRQLESPN-------------LRQLLSWIDLEFNHPQIFIVENGWFVSG 421

Query: 1280 NPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWSLMDNFEWLNGYTVKFGLYHVDF 1339
                +D   ++Y K +I E LKA +LDG+D+ GY AWSLMD FEW  GY+++ GL++VDF
Sbjct: 422  TTKRDDAKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDF 481

Query: 1340 NNTNRPRTARASARYYTEVITNNGMPLAREDEFLYGRFPEGFIWSAASAAYQIEGAW-RA 1398
             + ++    ++SA +Y ++I  NG P   E++ L G FP  F W       Q++    + 
Sbjct: 482  LSQDKMLLPKSSALFYQKLIEKNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQF 541

Query: 1399 DGKGLSIWDTFSHTPLRVENDAI----GDVACDSYHKIAEDLVTLQNLGVSHYRFSISWS 1454
                + +WD   H+   ++ D +        C  +  I   +  LQ + V+H+RFS+ W+
Sbjct: 542  TDLNVYLWDV-HHSKRLIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWA 600

Query: 1455 RILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIY-----HWDLPQTLQDVGGWENE 1509
             ILP G    +N   L YY  +   L+  +I P V ++     +  LP+ L   G WEN 
Sbjct: 601  LILPLGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENP 660

Query: 1510 TIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAPGVSNRPGTAPYIVGH 1569
                 F EYA + FQ LG  VK WIT+NEP+                        Y  GH
Sbjct: 661  YTALAFAEYARLCFQELGHHVKLWITMNEPYT-------------------RNMTYSAGH 701

Query: 1570 NLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDVEAARRYVQFMGGWFA 1629
            NL+KAHA AWH+YN+ +R +Q G ISI + +DW EP  P +Q+D E A R ++F  GW A
Sbjct: 702  NLLKAHALAWHVYNEKFRHAQNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLA 761

Query: 1630 HPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGFNHYTTVLAY 1689
             PIF +GDY  VM+  +  R      N   LP FTE EK+ I GT+DF   +HYTT+L  
Sbjct: 762  EPIFGSGDYPWVMRDWLNQR------NNFLLPYFTEDEKKLIQGTFDFLALSHYTTILVD 815

Query: 1690 NLNYATAISSFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEYNDPPIYVTE 1749
            +         ++    V  + D +W +S S  + + P+G R++LNWLK +Y D P+Y+  
Sbjct: 816  SEKEDPI--KYNDYLEVQEMTDITWLNSPS-QVAVVPWGLRKVLNWLKFKYGDLPMYIIS 872

Query: 1750 NGVSQREETDLNDTARIYYLRTYINEALKA-VQDKVDLRGYTVWSAMDNFEWATGFSERF 1808
            NG+      + +D  R+YY++ YINEALKA + D ++L GY  +S  D        + RF
Sbjct: 873  NGIDDGLHAE-DDQLRVYYMQNYINEALKAHILDGINLCGYFAYSFNDR------TAPRF 925

Query: 1809 GLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPDPATGPHAC 1850
            GL+   Y+       PKAS K Y  ++  NGFP P T    C
Sbjct: 926  GLY--RYAADQFE--PKASMKHYRKIIDSNGFPGPETLERFC 963



 Score =  594 bits (1531), Expect = e-169
 Identities = 364/1034 (35%), Positives = 519/1034 (50%), Gaps = 152/1034 (14%)

Query: 363  WEAFANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAEGGRGVSIWD-----PRRPL 417
            W  F+     E     Q TFP+GFLW   + A+  EGGW + G+G SIWD     P  P 
Sbjct: 42   WARFSRPPAPEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPP 101

Query: 418  NTTEGQ------------ATLEVASDSYHKVASDVALLCGLRAQVYKFSISWSRIFPMGH 465
              +               AT +VASDSY+ V  D   L  L    Y+FSISW+R+ P G 
Sbjct: 102  GDSRNASLPLGAPSPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGS 161

Query: 466  GSSPSLPGVAYYNKLIDRLQDAGIEPMATLFHWDLPQALQD-HGGWQNESVVDAFLDYAA 524
               P+  G+ YY +L++RL++ G++P+ TL+HWDLPQ LQD +GGW N ++ D F DYA 
Sbjct: 162  AGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAE 221

Query: 525  FCFSTFGDRVKLWVTFHEPWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHH 584
             CF  FG +VK W+T   P+V+++ GY TG+  PGI       + VAH +L AHA+ WH 
Sbjct: 222  LCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHL 281

Query: 585  YNSHHRPQQQGHVGIVLNSDWAEPLSPERPED--LRASERFLHFMLGWFAHPVFVDGDYP 642
            YN+  RP Q G V I L+S W   ++P R  D  ++  ++ L F+LGWFA PVF+DGDYP
Sbjct: 282  YNTSFRPTQGGQVSIALSSHW---INPRRMTDHSIKECQKSLDFVLGWFAKPVFIDGDYP 338

Query: 643  ATLRTQIQQMNRQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPS 702
             +++  +  +          LP+FTE+EK+ +KG+ADF  L               C   
Sbjct: 339  ESMKNNLSSI----------LPDFTESEKKFIKGTADFFAL---------------CFGP 373

Query: 703  YDTIGGFSQHVNHVWPQTSSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGES 762
              +      H+   + Q  S         +R+LL ++ LE+   +  I++  NG  +  +
Sbjct: 374  TLSFQLLDPHMK--FRQLESP-------NLRQLLSWIDLEFNHPQ--IFIVENGWFVSGT 422

Query: 763  ENLFDDSLRVDYFNQYINEVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNF 822
                DD+  + Y  ++I E LKAIK D VDV  Y A SL+DGFE   GYS R GL +V+F
Sbjct: 423  TKR-DDAKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDF 481

Query: 823  SDSSKSRTPRKSAYFFTSIIEKNGFLTKGAKRLLPPNTVNLPSKVRAFTFPSEVPSKAKV 882
                K   P+ SA F+  +IEKNGF         PP   N P                  
Sbjct: 482  LSQDKMLLPKSSALFYQKLIEKNGF---------PPLPENQP------------------ 514

Query: 883  VWEKFSSQPKFERDLFYHGTFRDDFLWGVSSSAYQIEGAWDA-DGKGPSIWDNFTHTPGS 941
                              GTF  DF WGV  +  Q++            +WD   H    
Sbjct: 515  ----------------LEGTFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWD--VHHSKR 556

Query: 942  NVKDNAT----GDIACDSYHQLDADLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGV 997
             +K +          C  +  +   + +L+ + V  +RFS+ W+ I P G  S +N   +
Sbjct: 557  LIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTIL 616

Query: 998  DYYNRLINGLVASNIFPMVTLF-----HWDLPQALQDIGGWENPALIDLFDSYADFCFQT 1052
             YY  + + LV  NI P+V L+     +  LP+ L   G WENP     F  YA  CFQ 
Sbjct: 617  QYYRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARLCFQE 676

Query: 1053 FGDRVKFWMTFNEPMYLAWLGYGSGEFPPGVKDPGWAPYRIAHAVIKAHARVYHTYDEKY 1112
             G  VK W+T NEP Y   + Y +G                 H ++KAHA  +H Y+EK+
Sbjct: 677  LGHHVKLWITMNEP-YTRNMTYSAG-----------------HNLLKAHALAWHVYNEKF 718

Query: 1113 RQEQKGVISLSLSTHWAEPKSPGVPRDVEAADRMLQFSLGWFAHPIFRNGDYPDTMKWKV 1172
            R  Q G IS++L   W EP  P   +D E A+R+L+F +GW A PIF +GDYP  M+  +
Sbjct: 719  RHAQNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWL 778

Query: 1173 GNRSELQHLATSRLPSFTEEEKRFIRATADVFCLNTYYSRIVQHKTPRLNPPSYEDDQEM 1232
              R+         LP FTE+EK+ I+ T D   L+ Y + +V   + + +P  Y D  E+
Sbjct: 779  NQRNNF------LLPYFTEDEKKLIQGTFDFLALSHYTTILVD--SEKEDPIKYNDYLEV 830

Query: 1233 AEEEDPSW-PSTAMNRAAPWGTRRLLNWIKEEYGDIPIYITENGVGLTNPNTEDTDRIFY 1291
             E  D +W  S +     PWG R++LNW+K +YGD+P+YI  NG+       +D  R++Y
Sbjct: 831  QEMTDITWLNSPSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYY 890

Query: 1292 HKTYINEALKAYRLDGIDLRGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARAS 1351
             + YINEALKA+ LDGI+L GY A+S  D          +FGLY    +        +AS
Sbjct: 891  MQNYINEALKAHILDGINLCGYFAYSFNDR------TAPRFGLYRYAADQFE----PKAS 940

Query: 1352 ARYYTEVITNNGMP 1365
             ++Y ++I +NG P
Sbjct: 941  MKHYRKIIDSNGFP 954



 Score =  287 bits (734), Expect = 8e-77
 Identities = 238/856 (27%), Positives = 357/856 (41%), Gaps = 138/856 (16%)

Query: 84  ITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKALKTARLQPMVILHHQTLPASTLRR 143
           +THY+  +SWA++LP GS   P+ + ++ YRRLL+ L+   +QP+V L+H  LP      
Sbjct: 144 VTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDA 203

Query: 144 -----TEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIKELPHQESRASQ------- 191
                  A AD F DYA   F  FG  V  W T  D   V+    +   R +        
Sbjct: 204 YGGWANRALADHFRDYAELCFRHFGGQVKYWITI-DNPYVVAWHGYATGRLAPGIRGSPR 262

Query: 192 -----LQTLSDAHRKAYEIYHESYA-FQGGKLSVVLRAE--------------------- 224
                   L  AH K + +Y+ S+   QGG++S+ L +                      
Sbjct: 263 LGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSSHWINPRRMTDHSIKECQKSLDF 322

Query: 225 -------------DIPELLLEPPISALA----------QDTVDFLSL------------- 248
                        D PE +     S L           + T DF +L             
Sbjct: 323 VLGWFAKPVFIDGDYPESMKNNLSSILPDFTESEKKFIKGTADFFALCFGPTLSFQLLDP 382

Query: 249 DLSYECQNEASLRQKLSKLQTIEPKVKVFIFNLKLPDCPSTMKNPASLLFSL-------F 301
            + +      +LRQ LS +       ++FI         +T ++ A  ++ L        
Sbjct: 383 HMKFRQLESPNLRQLLSWIDLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETL 442

Query: 302 EAINKDQVLTIGFDINEFLSCSSSSKKSMSCSLTGSLALQPDQQQDHETTDSSPASAYQR 361
           +AI  D V  IG+      S     +     S+   L       QD      S A  YQ+
Sbjct: 443 KAIKLDGVDVIGYTA---WSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQK 499

Query: 362 IWEAFANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAE-GGRGVSIWDPRRPLNTT 420
           + E        E    L+ TFP  F WG       V+   ++     V +WD        
Sbjct: 500 LIEKNGFPPLPENQP-LEGTFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWDVHHSKRLI 558

Query: 421 EGQATLEVASDSY----HKVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAY 476
           +    +     SY      +   +ALL  +    ++FS+ W+ I P+G+ S  +   + Y
Sbjct: 559 KVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQY 618

Query: 477 YNKLIDRLQDAGIEPMATLF-----HWDLPQALQDHGGWQNESVVDAFLDYAAFCFSTFG 531
           Y  +   L    I P+  L+     +  LP+ L   G W+N     AF +YA  CF   G
Sbjct: 619 YRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARLCFQELG 678

Query: 532 DRVKLWVTFHEPWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRP 591
             VKLW+T +EP+  +                   ++   H +LKAHA  WH YN   R 
Sbjct: 679 HHVKLWITMNEPYTRNM------------------TYSAGHNLLKAHALAWHVYNEKFRH 720

Query: 592 QQQGHVGIVLNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQ 651
            Q G + I L +DW EP  P   +D   +ER L F +GW A P+F  GDYP  +R  + Q
Sbjct: 721 AQNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQ 780

Query: 652 MNRQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQ 711
            N         LP FTE EK+L++G+ DFL LSHYT+ L+ +  ++     Y+      +
Sbjct: 781 RNN------FLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDPI--KYNDYLEVQE 832

Query: 712 HVNHVWPQTSSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLR 771
             +  W   S S + VVPWG+R++L ++  +Y  G +P+Y+  NG  I +  +  DD LR
Sbjct: 833 MTDITW-LNSPSQVAVVPWGLRKVLNWLKFKY--GDLPMYIISNG--IDDGLHAEDDQLR 887

Query: 772 VDYFNQYINEVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTP 831
           V Y   YINE LKA   D +++  Y A S  D        + RFGL+      ++    P
Sbjct: 888 VYYMQNYINEALKAHILDGINLCGYFAYSFND------RTAPRFGLYRY----AADQFEP 937

Query: 832 RKSAYFFTSIIEKNGF 847
           + S   +  II+ NGF
Sbjct: 938 KASMKHYRKIIDSNGF 953



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 44/157 (28%), Positives = 68/157 (43%), Gaps = 19/157 (12%)

Query: 79  LHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKALKTARLQPMVILHHQTLPA 138
           L    +TH++  L WA +LP G+    +   +Q YR +   L    + P+V L     P 
Sbjct: 585 LQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPN 644

Query: 139 STLRRTEA---------FADLFADYATFAFHSFGDLVGIWFTFSDLEEVIKELPHQESRA 189
             L R  A          A  FA+YA   F   G  V +W T ++        P+  +  
Sbjct: 645 QGLPRLLARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNE--------PYTRNMT 696

Query: 190 -SQLQTLSDAHRKAYEIYHESYAF-QGGKLSVVLRAE 224
            S    L  AH  A+ +Y+E +   Q GK+S+ L+A+
Sbjct: 697 YSAGHNLLKAHALAWHVYNEKFRHAQNGKISIALQAD 733


>gi|28376633 klotho beta [Homo sapiens]
          Length = 1044

 Score =  638 bits (1645), Expect = 0.0
 Identities = 368/1015 (36%), Positives = 542/1015 (53%), Gaps = 82/1015 (8%)

Query: 881  KVVWEKFSS-QPKFERDLFYHGTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTP 939
            + +W K  +  P  E  LF + TF  +F WG+ + A Q+EG+W  DGKGPSIWD+F HT 
Sbjct: 58   RAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHT- 116

Query: 940  GSNVKDNATGDIACDSYHQLDADLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDY 999
              ++K+ ++ + + DSY  L+ DL+ L  + V  Y+FSISW R+FP G  +  N+ G+ Y
Sbjct: 117  --HLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQY 174

Query: 1000 YNRLINGLVASNIFPMVTLFHWDLPQALQD-IGGWENPALIDLFDSYADFCFQTFGDRVK 1058
            Y+ L++ LV  NI P+VTL+HWDLP ALQ+  GGW+N  +ID+F+ YA +CFQ FGDRVK
Sbjct: 175  YSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVK 234

Query: 1059 FWMTFNEPMYLAWLGYGSGEFPPGVKDPGWAPYRIAHAVIKAHARVYHTYDEKYRQEQKG 1118
            +W+T + P  +AW GYG+G   PG K    A Y + H +IKAH++V+H Y+  +R  QKG
Sbjct: 235  YWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKG 294

Query: 1119 VISLSLSTHWAEPKSPGVPRDVEAADRMLQFSLGWFAHPIFRNGDYPDTMKWKVGNRSEL 1178
             +S++L +HW EP       D+    + +   LGWFA+PI  +GDYP+ M+ K+      
Sbjct: 295  WLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKL------ 348

Query: 1179 QHLATSRLPSFTEEEKRFIRATADVFCLNTYYSRIVQHKTPRLNPPSYEDDQEMAEEEDP 1238
                 S LP F+E EK  +R TAD F  +               P +++    MA+    
Sbjct: 349  ----FSVLPIFSEAEKHEMRGTADFFAFS-------------FGPNNFKPLNTMAK---- 387

Query: 1239 SWPSTAMNRAAPWGTRRLLNWIKEEYGDIPIYITENG-VGLTNPNTEDTDRIFYHKTYIN 1297
                  M +      R  LNWIK EY +  I I ENG    +   TEDT  I+  K +++
Sbjct: 388  ------MGQNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLS 441

Query: 1298 EALKAYRLDGIDLRGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTE 1357
            + L+A RLD I + GY AWSL+D FEW + YT++ GL++VDFN+  + R  ++SA YY +
Sbjct: 442  QVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQ 501

Query: 1358 VITNNGMPLAREDEFLYGRFPEGFIWSAASAAYQIEGAWRA---DGKGLSIWDTFSHTPL 1414
            +I  NG  L      + G+FP  F W    +  + E    +       L +W+   +  L
Sbjct: 502  IIRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLL 561

Query: 1415 -RVENDAI--GDVACDSYHKIAEDLVTLQNLGVSHYRFSISWSRILPDGTTRYINEAGLN 1471
             RVE   +      C  +  I + L  L  + V+HYRF++ W+ +LP G    +N   L 
Sbjct: 562  HRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALR 621

Query: 1472 YYVRLIDTLLAASIQPQVTIY-----HWDLPQTLQDVGGWENETIVQRFKEYADVLFQRL 1526
            YY  ++   L   I   VT+Y     H  LP+ L    GW N +  + F+ YA + FQ L
Sbjct: 622  YYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQEL 681

Query: 1527 GDKVKFWITLNEPFVIAYQGYGYGTAAPGVSNRPGTAPYIVGHNLIKAHAEAWHLYNDVY 1586
            GD VK WIT+NEP                + NR G   Y   HNL+ AHA AW LY+  +
Sbjct: 682  GDLVKLWITINEP-----------NRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQF 730

Query: 1587 RASQGGVISITISSDWAEPRDPSNQEDVEAARRYVQFMGGWFAHPIFKNGDYNEVMKTRI 1646
            R SQ G +S+++ +DWAEP +P       AA R++QF   WFA P+FK GDY   M+  I
Sbjct: 731  RPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYI 790

Query: 1647 RDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGFNHYTTVLAYNLNYATAISSFDADRGV 1706
              +    GL+ S LP  TE+E+R + GT DF   NH+TT   + ++   A S +D+DR +
Sbjct: 791  ASKH-RRGLSSSALPRLTEAERRLLKGTVDFCALNHFTT--RFVMHEQLAGSRYDSDRDI 847

Query: 1707 ASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEYNDPPIYVTENGVSQREETDLNDTARI 1766
              + D +   S +  L + P+G R++L W++  Y D  IY+T +G+  +   D  D  R 
Sbjct: 848  QFLQDITRLSSPT-RLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALED--DRLRK 904

Query: 1767 YYLRTYINEALKA-VQDKVDLRGYTVWSAMDNFEWATGFSERFGLHFVNYSDPSLPRIPK 1825
            YYL  Y+ E LKA + DKV ++GY  +   +          RFG    ++         K
Sbjct: 905  YYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKS-----KPRFGFFTSDFK-------AK 952

Query: 1826 ASAKFYASVVRCNGFPDPATGPHACLHQPDAGPTIS--PVRQEEVQFLGLMLGTT 1878
            +S +FY  V+   GFP   +       Q +   T+    V+++ + FLG    +T
Sbjct: 953  SSIQFYNKVISSRGFPFENSSSRCSQTQENTECTVCLFLVQKKPLIFLGCCFFST 1007



 Score =  580 bits (1496), Expect = e-165
 Identities = 346/1019 (33%), Positives = 520/1019 (51%), Gaps = 148/1019 (14%)

Query: 373  ERDAFLQDTFPEGFLWGASTGAFNVEGGWAEGGRGVSIWDP-----RRPLNTTEGQATLE 427
            E   FL DTFP+ F WG  TGA  VEG W + G+G SIWD       + +++T G     
Sbjct: 72   ESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG----- 126

Query: 428  VASDSYHKVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKLIDRLQDA 487
             +SDSY  +  D++ L  +    Y+FSISW R+FP G  +  +  G+ YY+ L+D L   
Sbjct: 127  -SSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLR 185

Query: 488  GIEPMATLFHWDLPQALQD-HGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTFHEPWVM 546
             IEP+ TL+HWDLP ALQ+ +GGW+N++++D F DYA +CF  FGDRVK W+T H P+++
Sbjct: 186  NIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLV 245

Query: 547  SYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIVLNSDWA 606
            ++ GYGTG H PG      A + V H ++KAH++ WH+YN+H RP Q+G + I L S W 
Sbjct: 246  AWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWI 305

Query: 607  EPLSPERPEDLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQMNRQCSHPVAQLPEF 666
            EP   E   D+   ++ +  +LGWFA+P+  DGDYP  +R ++           + LP F
Sbjct: 306  EPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKL----------FSVLPIF 355

Query: 667  TEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQHVNHVWPQTSSSWIR 726
            +EAEK  ++G+ADF   S          P N      +T+    Q+V+            
Sbjct: 356  SEAEKHEMRGTADFFAFSF--------GPNN--FKPLNTMAKMGQNVS------------ 393

Query: 727  VVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYINEVLKAI 786
                 +R  L ++ LEY   +  I +A NG    +S    +D+  +     ++++VL+AI
Sbjct: 394  ---LNLREALNWIKLEYNNPR--ILIAENGW-FTDSRVKTEDTTAIYMMKNFLSQVLQAI 447

Query: 787  KEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTSIIEKNG 846
            + D + V  Y A SL+DGFE    Y+ R GL +V+F+   K R P+ SA+++  II +NG
Sbjct: 448  RLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENG 507

Query: 847  FLTKGAKRLLPPNTVNLPSKVRAFTFPSEVPSKAKVVWEKFSSQPKFERDLFYHGTFRDD 906
            F  K                                      S P  +      G F  D
Sbjct: 508  FSLK-------------------------------------ESTPDVQ------GQFPCD 524

Query: 907  FLWGVSSSAYQIEG-------------AWDADGKGPSIWDNFTH-TPGSNVKDNATGDIA 952
            F WGV+ S  + E               W+A G      +   H   G  +K   T    
Sbjct: 525  FSWGVTESVLKPESVASSPQFSDPHLYVWNATG------NRLLHRVEGVRLK---TRPAQ 575

Query: 953  CDSYHQLDADLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNI 1012
            C  +  +   L ML  +KV  YRF++ W+ + PTG  S++N   + YY  +++  +   I
Sbjct: 576  CTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGI 635

Query: 1013 FPMVTLF-----HWDLPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPM 1067
              MVTL+     H  LP+ L    GW NP+  + F +YA  CFQ  GD VK W+T NEP 
Sbjct: 636  SAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPN 695

Query: 1068 YLAWLGYGSGEFPPGVKDPGWAPYRIAHAVIKAHARVYHTYDEKYRQEQKGVISLSLSTH 1127
             L+ +   SG             Y  AH ++ AHA  +  YD ++R  Q+G +SLSL   
Sbjct: 696  RLSDIYNRSGN----------DTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHAD 745

Query: 1128 WAEPKSPGVPRDVEAADRMLQFSLGWFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLP 1187
            WAEP +P       AA+R LQF + WFA P+F+ GDYP  M+  + ++   + L++S LP
Sbjct: 746  WAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHR-RGLSSSALP 804

Query: 1188 SFTEEEKRFIRATADVFCLNTYYSRIVQHKTPRLNPPSYEDDQEMAEEEDPSWPSTAMNR 1247
              TE E+R ++ T D   LN + +R V H+  +L    Y+ D+++   +D +  S+    
Sbjct: 805  RLTEAERRLLKGTVDFCALNHFTTRFVMHE--QLAGSRYDSDRDIQFLQDITRLSSPTRL 862

Query: 1248 AA-PWGTRRLLNWIKEEYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLD 1306
            A  PWG R+LL W++  YGD+ IYIT +G+       +D  R +Y   Y+ E LKAY +D
Sbjct: 863  AVIPWGVRKLLRWVRRNYGDMDIYITASGID-DQALEDDRLRKYYLGKYLQEVLKAYLID 921

Query: 1307 GIDLRGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMP 1365
             + ++GY A+ L +          +FG +  DF        A++S ++Y +VI++ G P
Sbjct: 922  KVRIKGYYAFKLAEEKS-----KPRFGFFTSDFK-------AKSSIQFYNKVISSRGFP 968



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 52/182 (28%), Positives = 80/182 (43%), Gaps = 24/182 (13%)

Query: 57  GDKDMYVCHQPLPTFLPEYFSSLHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRL 116
           G  D Y+       FL +  S+L    ++ Y+  +SW +L P G     + K +Q Y  L
Sbjct: 126 GSSDSYI-------FLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTL 178

Query: 117 LKALKTARLQPMVILHHQTLPASTLR-----RTEAFADLFADYATFAFHSFGDLVGIWFT 171
           L AL    ++P+V L+H  LP +        + +   D+F DYAT+ F  FGD V  W T
Sbjct: 179 LDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWIT 238

Query: 172 FSDLEEVI-------KELPHQESRASQLQT----LSDAHRKAYEIYHESY-AFQGGKLSV 219
             +   V           P ++   + + T    L  AH K +  Y+  +   Q G LS+
Sbjct: 239 IHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSI 298

Query: 220 VL 221
            L
Sbjct: 299 TL 300



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 41/155 (26%), Positives = 70/155 (45%), Gaps = 15/155 (9%)

Query: 83  QITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKALKTARLQPMVILHHQT-----LP 137
           ++THY+  L WA +LP G+    + + ++ YR ++       +  MV L++ T     LP
Sbjct: 593 KVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLP 652

Query: 138 ASTLRR----TEAFADLFADYATFAFHSFGDLVGIWFTFSD---LEEVIKELPHQESRAS 190
              L        + A+ F  YA   F   GDLV +W T ++   L ++     +    A+
Sbjct: 653 EPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGNDTYGAA 712

Query: 191 QLQTLSDAHRKAYEIYHESY-AFQGGKLSVVLRAE 224
               L  AH  A+ +Y   +   Q G +S+ L A+
Sbjct: 713 --HNLLVAHALAWRLYDRQFRPSQRGAVSLSLHAD 745


>gi|110681710 lactase-like [Homo sapiens]
          Length = 567

 Score =  483 bits (1244), Expect = e-136
 Identities = 234/480 (48%), Positives = 320/480 (66%), Gaps = 7/480 (1%)

Query: 1369 EDEFLYGRFPEGFIWSAASAAYQIEGAWRADGKGLSIWDTFSHTPL-RVENDAIGDVACD 1427
            E  F YG FP GF W   S+AYQ EGAW  DGKG SIWD F+H+   +V  +   DVACD
Sbjct: 29   EASFYYGTFPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHSGKGKVLGNETADVACD 88

Query: 1428 SYHKIAEDLVTLQNLGVSHYRFSISWSRILPDGT-TRYINEAGLNYYVRLIDTLLAASIQ 1486
             Y+K+ ED++ L+ L V+HYRFS+SW R+LP G     +N+ G+ +Y  LID LL+++I 
Sbjct: 89   GYYKVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNIT 148

Query: 1487 PQVTIYHWDLPQTLQ-DVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQ 1545
            P VT++HWDLPQ LQ   GGW+N ++   F++YA++ F+  GD+VK WIT ++P  +A +
Sbjct: 149  PIVTLHHWDLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRAMAEK 208

Query: 1546 GYGYGTAAPGVSNRPGTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEP 1605
            GY  G  APG+  R GT  Y   H++IKAHA+AWH YN  +R+ Q G++ I+++ DW EP
Sbjct: 209  GYETGHHAPGLKLR-GTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLNCDWGEP 267

Query: 1606 RDPSNQEDVEAARRYVQFMGGWFAHPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTE 1665
             D SN +D+EAA RY+QF  GWFA+PI+  GDY +VMK  I  +S   GL  SRLP F+ 
Sbjct: 268  VDISNPKDLEAAERYLQFCLGWFANPIYA-GDYPQVMKDYIGRKSAEQGLEMSRLPVFSL 326

Query: 1666 SEKRRINGTYDFFGFNHYTTVLAYNLNYATAIS-SFDADRGVASIADRSWPDSGSFWLKM 1724
             EK  I GT DF G  H+TT      NY +    S+  DR +  + D +WPD GS WL  
Sbjct: 327  QEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGPSYQNDRDLIELVDPNWPDLGSKWLYS 386

Query: 1725 TPFGFRRILNWLKEEYNDPPIYVTENGVSQREE-TDLNDTARIYYLRTYINEALKAVQDK 1783
             P+GFRR+LN+ + +Y DPPIYV ENG SQ+   T L D  RI YL+ YINE LKA++D 
Sbjct: 387  VPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKAIKDG 446

Query: 1784 VDLRGYTVWSAMDNFEWATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPDP 1843
             +++GYT WS +D FEW  G+S+R+G ++V ++D + PR PKAS ++Y  ++  NGFP+P
Sbjct: 447  ANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKKIIIANGFPNP 506



 Score =  476 bits (1225), Expect = e-134
 Identities = 234/488 (47%), Positives = 322/488 (65%), Gaps = 9/488 (1%)

Query: 894  ERDLFYHGTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIAC 953
            E   FY+GTF   F WGV SSAYQ EGAWD DGKGPSIWD FTH+    V  N T D+AC
Sbjct: 28   EEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHSGKGKVLGNETADVAC 87

Query: 954  DSYHQLDADLNMLRALKVKAYRFSISWSRIFPTG-RNSSINSHGVDYYNRLINGLVASNI 1012
            D Y+++  D+ +LR L V  YRFS+SW R+ PTG R   +N  G+++Y+ LI+ L++SNI
Sbjct: 88   DGYYKVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNI 147

Query: 1013 FPMVTLFHWDLPQALQ-DIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAW 1071
             P+VTL HWDLPQ LQ   GGW+N ++ + F  YA+ CF+ FGDRVK W+TF++P  +A 
Sbjct: 148  TPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRAMAE 207

Query: 1072 LGYGSGEFPPGVKDPGWAPYRIAHAVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEP 1131
             GY +G   PG+K  G   Y+ AH +IKAHA+ +H+Y+  +R +Q+G++ +SL+  W EP
Sbjct: 208  KGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLNCDWGEP 267

Query: 1132 KSPGVPRDVEAADRMLQFSLGWFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLPSFTE 1191
                 P+D+EAA+R LQF LGWFA+PI+  GDYP  MK  +G +S  Q L  SRLP F+ 
Sbjct: 268  VDISNPKDLEAAERYLQFCLGWFANPIYA-GDYPQVMKDYIGRKSAEQGLEMSRLPVFSL 326

Query: 1192 EEKRFIRATADVFCLNTYYSR-IVQHKTPRLNPPSYEDDQEMAEEEDPSWPSTAMN--RA 1248
            +EK +I+ T+D   L  + +R I +   P    PSY++D+++ E  DP+WP        +
Sbjct: 327  QEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGPSYQNDRDLIELVDPNWPDLGSKWLYS 386

Query: 1249 APWGTRRLLNWIKEEYGDIPIYITENGVGLTNPNTE--DTDRIFYHKTYINEALKAYRLD 1306
             PWG RRLLN+ + +YGD PIY+ ENG       T+  D  RI Y K YINE LKA + D
Sbjct: 387  VPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKAIK-D 445

Query: 1307 GIDLRGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMPL 1366
            G +++GY +WSL+D FEW  GY+ ++G Y+V+FN+ N+PR  +AS +YY ++I  NG P 
Sbjct: 446  GANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKKIIIANGFPN 505

Query: 1367 AREDEFLY 1374
             RE E  Y
Sbjct: 506  PREVESWY 513



 Score =  407 bits (1047), Expect = e-113
 Identities = 210/487 (43%), Positives = 283/487 (58%), Gaps = 11/487 (2%)

Query: 367 ANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAEGGRGVSIWD--PRRPLNTTEGQA 424
           A +   E  +F   TFP GF WG  + A+  EG W + G+G SIWD           G  
Sbjct: 22  ARKGSPEEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHSGKGKVLGNE 81

Query: 425 TLEVASDSYHKVASDVALLCGLRAQVYKFSISWSRIFPMG-HGSSPSLPGVAYYNKLIDR 483
           T +VA D Y+KV  D+ LL  L    Y+FS+SW R+ P G      +  G+ +Y+ LID 
Sbjct: 82  TADVACDGYYKVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDA 141

Query: 484 LQDAGIEPMATLFHWDLPQALQ-DHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTFHE 542
           L  + I P+ TL HWDLPQ LQ  +GGWQN S+ + F DYA  CF  FGDRVK W+TF +
Sbjct: 142 LLSSNITPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSD 201

Query: 543 PWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIVLN 602
           P  M+  GY TG H PG+   G   +K AH ++KAHA+ WH YN+  R +QQG VGI LN
Sbjct: 202 PRAMAEKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLN 261

Query: 603 SDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQMNRQCSHPVAQ 662
            DW EP+    P+DL A+ER+L F LGWFA+P++  GDYP  ++  I + + +    +++
Sbjct: 262 CDWGEPVDISNPKDLEAAERYLQFCLGWFANPIYA-GDYPQVMKDYIGRKSAEQGLEMSR 320

Query: 663 LPEFTEAEKQLLKGSADFLGLSHYTSRLIS--NAPQNTCIPSYDTIGGFSQHVNHVWPQT 720
           LP F+  EK  +KG++DFLGL H+T+R I+  N P     PSY       + V+  WP  
Sbjct: 321 LPVFSLQEKSYIKGTSDFLGLGHFTTRYITERNYPSRQG-PSYQNDRDLIELVDPNWPDL 379

Query: 721 SSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYIN 780
            S W+  VPWG RRLL F   +Y  G  PIY+  NG           D  R+ Y   YIN
Sbjct: 380 GSKWLYSVPWGFRRLLNFAQTQY--GDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYIN 437

Query: 781 EVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTS 840
           E+LKAIK D  +++ Y + SL+D FE   GYS R+G ++V F+D +K R P+ S  ++  
Sbjct: 438 EMLKAIK-DGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKK 496

Query: 841 IIEKNGF 847
           II  NGF
Sbjct: 497 IIIANGF 503



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 48/164 (29%), Positives = 79/164 (48%), Gaps = 18/164 (10%)

Query: 79  LHASQITHYKVFLSWAQLLPAG-STQNPDEKTVQCYRRLLKALKTARLQPMVILHHQTLP 137
           L    + HY+  LSW +LLP G   +  ++K ++ Y  L+ AL ++ + P+V LHH  LP
Sbjct: 100 LRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNITPIVTLHHWDLP 159

Query: 138 ASTLRR-----TEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIKE-------LPHQ 185
                +       + A+ F DYA   F +FGD V  W TFSD   + ++        P  
Sbjct: 160 QLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRAMAEKGYETGHHAPGL 219

Query: 186 ESRASQL----QTLSDAHRKAYEIYHESY-AFQGGKLSVVLRAE 224
           + R + L      +  AH KA+  Y+ ++ + Q G + + L  +
Sbjct: 220 KLRGTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLNCD 263


>gi|13273313 cytosolic beta-glucosidase isoform a [Homo sapiens]
          Length = 469

 Score =  454 bits (1167), Expect = e-127
 Identities = 216/463 (46%), Positives = 297/463 (64%), Gaps = 1/463 (0%)

Query: 903  FRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLDAD 962
            F   F W  +++AYQ+EG WDADGKGP +WD FTH  G  V  N TGD+AC SY   + D
Sbjct: 3    FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEED 62

Query: 963  LNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFHWD 1022
            L  ++ L +  YRFS+SWSR+ P G    IN  G+DYYN++I+ L+ + + P+VTL+H+D
Sbjct: 63   LKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYHFD 122

Query: 1023 LPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFPPG 1082
            LPQ L+D GGW + A+I+ FD YA FCF TFGDRVK W+T NE   L+ + Y  G FPPG
Sbjct: 123  LPQTLEDQGGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINEANVLSVMSYDLGMFPPG 182

Query: 1083 VKDPGWAPYRIAHAVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDVEA 1142
            +   G   Y+ AH +IKAHAR +H+YD  +R++QKG++SLSL   W EP  P    D EA
Sbjct: 183  IPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAVWLEPADPNSVSDQEA 242

Query: 1143 ADRMLQFSLGWFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRATAD 1202
            A R + F L  FA PIF +GDYP+ +K ++ + S+ Q   +SRLP FTEEEK+ I+ TAD
Sbjct: 243  AKRAITFHLDLFAKPIFIDGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGTAD 302

Query: 1203 VFCLNTYYSRIVQHKTPRLNPPSYEDDQEMAEEEDPSWPSTAMNRAAPWGTRRLLNWIKE 1262
             F +  Y +R+++++  +        D E+    DPSW +       PWG  +LL +IK+
Sbjct: 303  FFAVQYYTTRLIKYQENKKGELGILQDAEIEFFPDPSWKNVDWIYVVPWGVCKLLKYIKD 362

Query: 1263 EYGDIPIYITENGVGLTNP-NTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWSLMDN 1321
             Y +  IYITENG   ++P   +DT R  Y +    E  KA +LD ++L+ Y AWSL+DN
Sbjct: 363  TYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAWSLLDN 422

Query: 1322 FEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGM 1364
            FEW  GY+ +FGL+HVDF +  RPR    SA+ Y ++I NNG+
Sbjct: 423  FEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGL 465



 Score =  446 bits (1148), Expect = e-125
 Identities = 222/466 (47%), Positives = 302/466 (64%), Gaps = 7/466 (1%)

Query: 1377 FPEGFIWSAASAAYQIEGAWRADGKGLSIWDTFSHTP-LRVENDAIGDVACDSYHKIAED 1435
            FP GF W+AA+AAYQ+EG W ADGKG  +WDTF+H    RV  +  GDVAC SY    ED
Sbjct: 3    FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEED 62

Query: 1436 LVTLQNLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHWD 1495
            L  ++ LG++HYRFS+SWSR+LPDGTT +IN+ G++YY ++ID LL   + P VT+YH+D
Sbjct: 63   LKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYHFD 122

Query: 1496 LPQTLQDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAPG 1555
            LPQTL+D GGW +E I++ F +YA   F   GD+VK WIT+NE  V++   Y  G   PG
Sbjct: 123  LPQTLEDQGGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINEANVLSVMSYDLGMFPPG 182

Query: 1556 VSNRPGTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDVE 1615
            + +  GT  Y   HNLIKAHA +WH Y+ ++R  Q G++S+++ + W EP DP++  D E
Sbjct: 183  IPHF-GTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAVWLEPADPNSVSDQE 241

Query: 1616 AARRYVQFMGGWFAHPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTY 1675
            AA+R + F    FA PIF +GDY EV+K++I   S   G   SRLPEFTE EK+ I GT 
Sbjct: 242  AAKRAITFHLDLFAKPIFIDGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGTA 301

Query: 1676 DFFGFNHYTT-VLAYNLNYATAISSFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILN 1734
            DFF   +YTT ++ Y  N    +     D  +    D SW +    W+ + P+G  ++L 
Sbjct: 302  DFFAVQYYTTRLIKYQENKKGELGILQ-DAEIEFFPDPSWKNVD--WIYVVPWGVCKLLK 358

Query: 1735 WLKEEYNDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQ-DKVDLRGYTVWS 1793
            ++K+ YN+P IY+TENG  Q +   L+DT R  Y R    E  KA+Q DKV+L+ Y  WS
Sbjct: 359  YIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAWS 418

Query: 1794 AMDNFEWATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNG 1839
             +DNFEW  G+S RFGL  V++ DP+ PR+P  SAK YA ++R NG
Sbjct: 419  LLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNG 464



 Score =  373 bits (957), Expect = e-102
 Identities = 197/474 (41%), Positives = 277/474 (58%), Gaps = 21/474 (4%)

Query: 382 FPEGFLWGASTGAFNVEGGWAEGGRGVSIWDPRRPLNTTEG------QATLEVASDSYHK 435
           FP GF W A+T A+ VEGGW   G+G  +WD      T +G        T +VA  SY  
Sbjct: 3   FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTF----THQGGERVFKNQTGDVACGSYTL 58

Query: 436 VASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKLIDRLQDAGIEPMATL 495
              D+  +  L    Y+FS+SWSR+ P G     +  G+ YYNK+ID L   G+ P+ TL
Sbjct: 59  WEEDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTL 118

Query: 496 FHWDLPQALQDHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTFHEPWVMSYAGYGTGQ 555
           +H+DLPQ L+D GGW +E+++++F  YA FCFSTFGDRVK W+T +E  V+S   Y  G 
Sbjct: 119 YHFDLPQTLEDQGGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINEANVLSVMSYDLGM 178

Query: 556 HPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIVLNSDWAEPLSPERPE 615
            PPGI   G   ++ AH ++KAHAR+WH Y+S  R +Q+G V + L + W EP  P    
Sbjct: 179 FPPGIPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAVWLEPADPNSVS 238

Query: 616 DLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQMNRQCSHPVAQLPEFTEAEKQLLK 675
           D  A++R + F L  FA P+F+DGDYP  +++QI  M+++  +P ++LPEFTE EK+++K
Sbjct: 239 DQEAAKRAITFHLDLFAKPIFIDGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIK 298

Query: 676 GSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQHVNHVWPQTS---SSWIRVVPWGI 732
           G+ADF  + +YT+RLI              +G         +P  S     WI VVPWG+
Sbjct: 299 GTADFFAVQYYTTRLIKYQENKK-----GELGILQDAEIEFFPDPSWKNVDWIYVVPWGV 353

Query: 733 RRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYINEVLKAIKEDSVD 792
            +LL+++   Y      IY+  NG P  +   L DD+ R +YF Q   E+ KAI+ D V+
Sbjct: 354 CKLLKYIKDTY--NNPVIYITENGFPQSDPAPL-DDTQRWEYFRQTFQELFKAIQLDKVN 410

Query: 793 VRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTSIIEKNG 846
           ++ Y A SL+D FE   GYS RFGL HV+F D ++ R P  SA  +  II  NG
Sbjct: 411 LQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNG 464



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 33/95 (34%), Positives = 54/95 (56%), Gaps = 4/95 (4%)

Query: 84  ITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKALKTARLQPMVILHHQTLPASTLRR 143
           +THY+  LSW++LLP G+T   ++K +  Y +++  L    + P+V L+H  LP +   +
Sbjct: 71  LTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYHFDLPQTLEDQ 130

Query: 144 ----TEAFADLFADYATFAFHSFGDLVGIWFTFSD 174
               +EA  + F  YA F F +FGD V  W T ++
Sbjct: 131 GGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINE 165


>gi|190360571 cytosolic beta-glucosidase isoform b [Homo sapiens]
          Length = 162

 Score =  119 bits (297), Expect = 4e-26
 Identities = 55/95 (57%), Positives = 70/95 (73%), Gaps = 1/95 (1%)

Query: 1377 FPEGFIWSAASAAYQIEGAWRADGKGLSIWDTFSHTP-LRVENDAIGDVACDSYHKIAED 1435
            FP GF W+AA+AAYQ+EG W ADGKG  +WDTF+H    RV  +  GDVAC SY    ED
Sbjct: 3    FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEED 62

Query: 1436 LVTLQNLGVSHYRFSISWSRILPDGTTRYINEAGL 1470
            L  ++ LG++HYRFS+SWSR+LPDGTT +IN+  +
Sbjct: 63   LKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKAI 97



 Score =  106 bits (265), Expect = 2e-22
 Identities = 46/95 (48%), Positives = 59/95 (62%)

Query: 903 FRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLDAD 962
           F   F W  +++AYQ+EG WDADGKGP +WD FTH  G  V  N TGD+AC SY   + D
Sbjct: 3   FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEED 62

Query: 963 LNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGV 997
           L  ++ L +  YRFS+SWSR+ P G    IN   +
Sbjct: 63  LKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKAI 97



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 36/70 (51%), Positives = 51/70 (72%), Gaps = 2/70 (2%)

Query: 1295 YINEALKAYRLDGIDLRGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARY 1354
            +IN+  KA +LD ++L+ Y AWSL+DNFEW  GY+ +FGL+HVDF +  RPR    SA+ 
Sbjct: 91   FINQ--KAIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKE 148

Query: 1355 YTEVITNNGM 1364
            Y ++I NNG+
Sbjct: 149  YAKIIRNNGL 158



 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 37/69 (53%), Positives = 50/69 (72%), Gaps = 3/69 (4%)

Query: 1772 YINEALKAVQ-DKVDLRGYTVWSAMDNFEWATGFSERFGLHFVNYSDPSLPRIPKASAKF 1830
            +IN+  KA+Q DKV+L+ Y  WS +DNFEW  G+S RFGL  V++ DP+ PR+P  SAK 
Sbjct: 91   FINQ--KAIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKE 148

Query: 1831 YASVVRCNG 1839
            YA ++R NG
Sbjct: 149  YAKIIRNNG 157



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 33/69 (47%), Positives = 44/69 (63%), Gaps = 2/69 (2%)

Query: 778 YINEVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYF 837
           +IN+  KAI+ D V+++ Y A SL+D FE   GYS RFGL HV+F D ++ R P  SA  
Sbjct: 91  FINQ--KAIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKE 148

Query: 838 FTSIIEKNG 846
           +  II  NG
Sbjct: 149 YAKIIRNNG 157



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 33/85 (38%), Positives = 44/85 (51%), Gaps = 2/85 (2%)

Query: 382 FPEGFLWGASTGAFNVEGGWAEGGRGVSIWD--PRRPLNTTEGQATLEVASDSYHKVASD 439
           FP GF W A+T A+ VEGGW   G+G  +WD    +         T +VA  SY     D
Sbjct: 3   FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEED 62

Query: 440 VALLCGLRAQVYKFSISWSRIFPMG 464
           +  +  L    Y+FS+SWSR+ P G
Sbjct: 63  LKCIKQLGLTHYRFSLSWSRLLPDG 87



 Score = 33.5 bits (75), Expect = 2.1
 Identities = 13/28 (46%), Positives = 21/28 (75%)

Query: 84  ITHYKVFLSWAQLLPAGSTQNPDEKTVQ 111
           +THY+  LSW++LLP G+T   ++K +Q
Sbjct: 71  LTHYRFSLSWSRLLPDGTTGFINQKAIQ 98


>gi|148886707 hephaestin-like 1 [Homo sapiens]
          Length = 1159

 Score = 40.4 bits (93), Expect = 0.017
 Identities = 28/89 (31%), Positives = 39/89 (43%), Gaps = 1/89 (1%)

Query: 1838 NGFPDPATGPHACLHQPDAGPTISPVRQEEVQFLGLMLGTTEAQTALYVLFSLVLLGVCG 1897
            N  P   T P    H P   P+     +E++ F G  LG T A+ AL +LF + LL +  
Sbjct: 1071 NRIPYSTTSPGVASH-PATVPSNERPGKEQLYFFGKNLGPTGAKAALVILFIIGLLLLIT 1129

Query: 1898 LAFLSYKYCKRSKQGKTQRSQQELSPVSS 1926
               LS + C   KQ   Q+ Q    P  +
Sbjct: 1130 TVILSLRLCSAMKQTDYQQVQSCALPTDA 1158


>gi|33350932 cytoplasmic dynein 1 heavy chain 1 [Homo sapiens]
          Length = 4646

 Score = 33.9 bits (76), Expect = 1.6
 Identities = 34/113 (30%), Positives = 47/113 (41%), Gaps = 22/113 (19%)

Query: 1712 RSWPDSGSFWLKMTPFGFRRILNWLK---EEYNDPPIYVTENGVS------QREETDLND 1762
            R+   + S WL + P    + L+ LK   E   DP     E  V       Q    DL D
Sbjct: 4378 RTLHTTASNWLHLIP----QTLSHLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLAD 4433

Query: 1763 TARIY--------YLRTYINEALKAVQDKVDLRGYTVWSAMDNFEWATGFSER 1807
              ++         YLRT INE +K +  +     YTV + M   +W + FSER
Sbjct: 4434 VVQVCEGKKKQTNYLRTLINELVKGILPR-SWSHYTVPAGMTVIQWVSDFSER 4485


>gi|16905507 progressive ankylosis protein [Homo sapiens]
          Length = 492

 Score = 33.9 bits (76), Expect = 1.6
 Identities = 23/64 (35%), Positives = 37/64 (57%), Gaps = 5/64 (7%)

Query: 769 SLRVDYFNQYINEVLKAIKEDSVD-VRSY-IARSLIDGFEGPSGYSQRFGLHHVNFSDSS 826
           ++ +D+  Q +N  + A+KED+V+ + SY +A SL+  F GP    +  GL  VN   S 
Sbjct: 24  NIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVN---SK 80

Query: 827 KSRT 830
           + RT
Sbjct: 81  RDRT 84


>gi|169658367 BAH domain and coiled-coil containing 1 [Homo sapiens]
          Length = 2608

 Score = 31.6 bits (70), Expect = 7.8
 Identities = 17/52 (32%), Positives = 24/52 (46%), Gaps = 3/52 (5%)

Query: 1813 VNYSDPSLPRIPKASAKFYASVVRCNGFPDPATGP---HACLHQPDAGPTIS 1861
            ++  +P+  + PK++ K  A      G P PA GP     C H PD  P  S
Sbjct: 953  LDLEEPAQEKAPKSTHKPVALTPTAPGAPSPAAGPTKLPPCCHPPDPKPPAS 1004


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,532,985
Number of Sequences: 37866
Number of extensions: 3601688
Number of successful extensions: 8247
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 8053
Number of HSP's gapped (non-prelim): 35
length of query: 1927
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1810
effective length of database: 13,817,196
effective search space: 25009124760
effective search space used: 25009124760
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.