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Search of human proteins with 122937243
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|122937243 dual specificity phosphatase 27 [Homo sapiens]
(1158 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122937243 dual specificity phosphatase 27 [Homo sapiens] 2285 0.0
gi|51491914 dual specificity phosphatase and pro isomerase domai... 160 7e-39
gi|56117820 testis and skeletal muscle-specific dual specificity... 150 7e-36
gi|56237018 testis and skeletal muscle-specific dual specificity... 149 2e-35
gi|56117822 testis and skeletal muscle-specific dual specificity... 149 2e-35
gi|13128968 dual specificity phosphatase 26 [Homo sapiens] 147 4e-35
gi|56117818 muscle-restricted dual specificity phosphatase isofo... 144 5e-34
gi|4758208 dual specificity phosphatase 3 [Homo sapiens] 125 2e-28
gi|5902002 dual specificity phosphatase 14 [Homo sapiens] 76 2e-13
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 74 1e-12
gi|4503417 dual specificity phosphatase 4 isoform 1 [Homo sapiens] 73 1e-12
gi|16950652 dual specificity phosphatase 4 isoform 2 [Homo sapiens] 73 1e-12
gi|4503421 dual specificity phosphatase 9 [Homo sapiens] 72 2e-12
gi|4758204 dual specificity phosphatase 1 [Homo sapiens] 70 2e-11
gi|18254478 dual specificity phosphatase 19 isoform 1 [Homo sapi... 70 2e-11
gi|239750646 PREDICTED: hypothetical protein XP_002347464 [Homo ... 69 3e-11
gi|194733759 serine/threonine/tyrosine interacting protein [Homo... 69 3e-11
gi|21687043 serine/threonine/tyrosine interacting protein [Homo ... 69 3e-11
gi|9910432 dual specificity phosphatase 22 [Homo sapiens] 67 8e-11
gi|6005812 dual specificity phosphatase 10 isoform a [Homo sapiens] 67 1e-10
gi|29826315 dual specificity phosphatase 15 isoform a [Homo sapi... 67 1e-10
gi|239047498 slingshot 1 isoform 3 [Homo sapiens] 66 2e-10
gi|239047441 slingshot 1 isoform 2 [Homo sapiens] 66 2e-10
gi|239047414 slingshot 1 isoform 1 [Homo sapiens] 66 2e-10
gi|62865890 dual specificity phosphatase 5 [Homo sapiens] 66 2e-10
gi|239582767 slingshot homolog 3 [Homo sapiens] 65 5e-10
gi|4758206 dual specificity phosphatase 2 [Homo sapiens] 64 1e-09
gi|153281158 dual specificity phosphatase 8 [Homo sapiens] 64 1e-09
gi|38372911 dual specificity phosphatase 16 [Homo sapiens] 62 4e-09
gi|21536333 dual specificity phosphatase 10 isoform b [Homo sapi... 61 5e-09
>gi|122937243 dual specificity phosphatase 27 [Homo sapiens]
Length = 1158
Score = 2285 bits (5921), Expect = 0.0
Identities = 1158/1158 (100%), Positives = 1158/1158 (100%)
Query: 1 MATRKDTEEEQVVPSEEDEANVRAVQAHYLRSPSPSQYSMVSDAETESIFMEPIHLSSAI 60
MATRKDTEEEQVVPSEEDEANVRAVQAHYLRSPSPSQYSMVSDAETESIFMEPIHLSSAI
Sbjct: 1 MATRKDTEEEQVVPSEEDEANVRAVQAHYLRSPSPSQYSMVSDAETESIFMEPIHLSSAI 60
Query: 61 AAKQIINEELKPPGVRADAECPGMLESAEQLLVEDLYNRVREKMDDTSLYNTPCVLDLQR 120
AAKQIINEELKPPGVRADAECPGMLESAEQLLVEDLYNRVREKMDDTSLYNTPCVLDLQR
Sbjct: 61 AAKQIINEELKPPGVRADAECPGMLESAEQLLVEDLYNRVREKMDDTSLYNTPCVLDLQR 120
Query: 121 ALVQDRQEAPWNEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYT 180
ALVQDRQEAPWNEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYT
Sbjct: 121 ALVQDRQEAPWNEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYT 180
Query: 181 GLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYL 240
GLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYL
Sbjct: 181 GLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYL 240
Query: 241 MIFHNMAILEALMTVRKKRAIYPNEGFLKQLRELNEKLMEEREEDYGREGGSAEAEEGEG 300
MIFHNMAILEALMTVRKKRAIYPNEGFLKQLRELNEKLMEEREEDYGREGGSAEAEEGEG
Sbjct: 241 MIFHNMAILEALMTVRKKRAIYPNEGFLKQLRELNEKLMEEREEDYGREGGSAEAEEGEG 300
Query: 301 TGSMLGARVHALTVEEEDDSASHLSGSSLGKATQASKPLTLIDEEEEEKLYEQWKKGQGL 360
TGSMLGARVHALTVEEEDDSASHLSGSSLGKATQASKPLTLIDEEEEEKLYEQWKKGQGL
Sbjct: 301 TGSMLGARVHALTVEEEDDSASHLSGSSLGKATQASKPLTLIDEEEEEKLYEQWKKGQGL 360
Query: 361 LSDKVPQDGGGWRSASSGQGGEELEDEDVERIIQEWQSRNERYQAEGYRRWGREEEKEEE 420
LSDKVPQDGGGWRSASSGQGGEELEDEDVERIIQEWQSRNERYQAEGYRRWGREEEKEEE
Sbjct: 361 LSDKVPQDGGGWRSASSGQGGEELEDEDVERIIQEWQSRNERYQAEGYRRWGREEEKEEE 420
Query: 421 SDAGSSVGRRRRTLSESSAWESVSSHDIWVLKQQLELNRPDHGRRRRADSMSSESTWDAW 480
SDAGSSVGRRRRTLSESSAWESVSSHDIWVLKQQLELNRPDHGRRRRADSMSSESTWDAW
Sbjct: 421 SDAGSSVGRRRRTLSESSAWESVSSHDIWVLKQQLELNRPDHGRRRRADSMSSESTWDAW 480
Query: 481 NERLLEIEKEASRRYHAKSKREEAADRSSEAGSRVREDDEDSVGSEASSFYNFCSRNKDK 540
NERLLEIEKEASRRYHAKSKREEAADRSSEAGSRVREDDEDSVGSEASSFYNFCSRNKDK
Sbjct: 481 NERLLEIEKEASRRYHAKSKREEAADRSSEAGSRVREDDEDSVGSEASSFYNFCSRNKDK 540
Query: 541 LTALERWKIKRIQFGFHKKDLGAGDSSGEPGAEEAVGEKNPSDVSLTAYQAWKLKHQKKV 600
LTALERWKIKRIQFGFHKKDLGAGDSSGEPGAEEAVGEKNPSDVSLTAYQAWKLKHQKKV
Sbjct: 541 LTALERWKIKRIQFGFHKKDLGAGDSSGEPGAEEAVGEKNPSDVSLTAYQAWKLKHQKKV 600
Query: 601 GSENKEEVVELSKGEDSALAKKRQRRLELLERSRQTLEESQSMASWEADSSTASGSIPLS 660
GSENKEEVVELSKGEDSALAKKRQRRLELLERSRQTLEESQSMASWEADSSTASGSIPLS
Sbjct: 601 GSENKEEVVELSKGEDSALAKKRQRRLELLERSRQTLEESQSMASWEADSSTASGSIPLS 660
Query: 661 AFWSADPSVSADGDTTSVLSTQSHRSHLSQAASNIAGCSTSNPTTPLPNLPVGPGDTISI 720
AFWSADPSVSADGDTTSVLSTQSHRSHLSQAASNIAGCSTSNPTTPLPNLPVGPGDTISI
Sbjct: 661 AFWSADPSVSADGDTTSVLSTQSHRSHLSQAASNIAGCSTSNPTTPLPNLPVGPGDTISI 720
Query: 721 ASIQNWIANVVSETLAQKQNEMLLLSRSPSVASMKAVPAASCLGDDQVSMLSGHSSSSLG 780
ASIQNWIANVVSETLAQKQNEMLLLSRSPSVASMKAVPAASCLGDDQVSMLSGHSSSSLG
Sbjct: 721 ASIQNWIANVVSETLAQKQNEMLLLSRSPSVASMKAVPAASCLGDDQVSMLSGHSSSSLG 780
Query: 781 GCLLPQSQARPSSDMQSVLSCNTTLSSPAESCRSKVRGTSKPIFSLFADNVDLKELGRKE 840
GCLLPQSQARPSSDMQSVLSCNTTLSSPAESCRSKVRGTSKPIFSLFADNVDLKELGRKE
Sbjct: 781 GCLLPQSQARPSSDMQSVLSCNTTLSSPAESCRSKVRGTSKPIFSLFADNVDLKELGRKE 840
Query: 841 KEMQMELREKMSEYKMEKLASDNKRSSLFKKKKVKEDEDDGVGDGDEDTDSAIGSFRYSS 900
KEMQMELREKMSEYKMEKLASDNKRSSLFKKKKVKEDEDDGVGDGDEDTDSAIGSFRYSS
Sbjct: 841 KEMQMELREKMSEYKMEKLASDNKRSSLFKKKKVKEDEDDGVGDGDEDTDSAIGSFRYSS 900
Query: 901 RSNSQKPETDTCSSLAVCDHYASGSRVGKEMDSSINKWLSGLRTEEKPPFQSDWSGSSRG 960
RSNSQKPETDTCSSLAVCDHYASGSRVGKEMDSSINKWLSGLRTEEKPPFQSDWSGSSRG
Sbjct: 901 RSNSQKPETDTCSSLAVCDHYASGSRVGKEMDSSINKWLSGLRTEEKPPFQSDWSGSSRG 960
Query: 961 KYTRSSLLRETESKSSSYKFSKSQSEEQDTSSYHEANGNSVRSTSRFSSSSTREGREMHK 1020
KYTRSSLLRETESKSSSYKFSKSQSEEQDTSSYHEANGNSVRSTSRFSSSSTREGREMHK
Sbjct: 961 KYTRSSLLRETESKSSSYKFSKSQSEEQDTSSYHEANGNSVRSTSRFSSSSTREGREMHK 1020
Query: 1021 FSRSTYNETSSSREESPEPYFFRRTPESSEREESPEPQRPNWARSRDWEDVEESSKSDFS 1080
FSRSTYNETSSSREESPEPYFFRRTPESSEREESPEPQRPNWARSRDWEDVEESSKSDFS
Sbjct: 1021 FSRSTYNETSSSREESPEPYFFRRTPESSEREESPEPQRPNWARSRDWEDVEESSKSDFS 1080
Query: 1081 EFGAKRKFTQSFMRSEEEGEKERTENREEGRFASGRRSQYRRSTDREEEEEMDDEAIIAA 1140
EFGAKRKFTQSFMRSEEEGEKERTENREEGRFASGRRSQYRRSTDREEEEEMDDEAIIAA
Sbjct: 1081 EFGAKRKFTQSFMRSEEEGEKERTENREEGRFASGRRSQYRRSTDREEEEEMDDEAIIAA 1140
Query: 1141 WRRRQEETRTKLQKRRED 1158
WRRRQEETRTKLQKRRED
Sbjct: 1141 WRRRQEETRTKLQKRRED 1158
>gi|51491914 dual specificity phosphatase and pro isomerase domain
containing 1 [Homo sapiens]
Length = 220
Score = 160 bits (405), Expect = 7e-39
Identities = 81/189 (42%), Positives = 122/189 (64%), Gaps = 3/189 (1%)
Query: 110 YNTPCVLDLQRALVQDRQEAPWNEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHG 169
Y TP +L+R + + + V+EVWP ++I +++ A+++ RL++ G TH+LNAAHG
Sbjct: 33 YCTPGAFELERLFWKGSPQ--YTHVNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHG 90
Query: 170 T-GVYTGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMG 228
V TGP++Y ++IQY GVE DD P D+S F A+ F+D AL K+LV MG
Sbjct: 91 RWNVDTGPDYYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDHSKILVHCVMG 150
Query: 229 ISRSAVLVVAYLMIFHNMAILEALMTVRKKRAIYPNEGFLKQLRELNEKLMEEREEDYGR 288
SRSA LV+AYLMI +M +++A+ V K R + PN GFLKQLREL+++L+++R +
Sbjct: 151 RSRSATLVLAYLMIHKDMTLVDAIQQVAKNRCVLPNRGFLKQLRELDKQLVQQRRRSQRQ 210
Query: 289 EGGSAEAEE 297
+G + E
Sbjct: 211 DGEEEDGRE 219
>gi|56117820 testis and skeletal muscle-specific dual specificity
phosphatase isoform 2 [Homo sapiens]
Length = 248
Score = 150 bits (379), Expect = 7e-36
Identities = 86/209 (41%), Positives = 126/209 (60%), Gaps = 4/209 (1%)
Query: 76 RADAECPGML--ESAEQLLVEDLYNRVREKMDDTSLYNTPCVLDLQRALVQDRQEAPWNE 133
R D P + ++ + L +DL S Y P + LQR L+ RQ A N
Sbjct: 37 RVDEVWPNLFIGDAMDSLQKQDLRRPKIHGAVQASPYQPPTLASLQR-LLWVRQAATLNH 95
Query: 134 VDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGT-GVYTGPEFYTGLEIQYLGVEVD 192
+DEVWP++F+ + A +K +L +LGITH++NAA G V TG +FY G+ ++Y G+E D
Sbjct: 96 IDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAGKFQVDTGAKFYRGMSLEYYGIEAD 155
Query: 193 DFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEAL 252
D P D+S +F + ++ AL +G+VLV MG+SRSA LV+A+LMI NM ++EA+
Sbjct: 156 DNPFFDLSVYFLPVARYIRAALSVPQGRVLVHCAMGVSRSATLVLAFLMICENMTLVEAI 215
Query: 253 MTVRKKRAIYPNEGFLKQLRELNEKLMEE 281
TV+ R I PN GFL+QL+ L+ +L E
Sbjct: 216 QTVQAHRNICPNSGFLRQLQVLDNRLGRE 244
Score = 33.9 bits (76), Expect = 0.92
Identities = 18/48 (37%), Positives = 28/48 (58%), Gaps = 4/48 (8%)
Query: 112 TPC--VLDLQRALVQDRQEAPWNEVDEVWPNVFIAEKSVAVNKGRLKR 157
TPC +L+L+ L + + VDEVWPN+FI + ++ K L+R
Sbjct: 16 TPCPSILELEELLRAGKSSC--SRVDEVWPNLFIGDAMDSLQKQDLRR 61
>gi|56237018 testis and skeletal muscle-specific dual specificity
phosphatase isoform 6 [Homo sapiens]
Length = 198
Score = 149 bits (376), Expect = 2e-35
Identities = 80/175 (45%), Positives = 115/175 (65%), Gaps = 2/175 (1%)
Query: 108 SLYNTPCVLDLQRALVQDRQEAPWNEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAA 167
S Y P + LQR L+ RQ A N +DEVWP++F+ + A +K +L +LGITH++NAA
Sbjct: 21 SPYQPPTLASLQR-LLWVRQAATLNHIDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAA 79
Query: 168 HGT-GVYTGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSE 226
G V TG +FY G+ ++Y G+E DD P D+S +F + ++ AL +G+VLV
Sbjct: 80 AGKFQVDTGAKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVPQGRVLVHCA 139
Query: 227 MGISRSAVLVVAYLMIFHNMAILEALMTVRKKRAIYPNEGFLKQLRELNEKLMEE 281
MG+SRSA LV+A+LMI NM ++EA+ TV+ R I PN GFL+QL+ L+ +L E
Sbjct: 140 MGVSRSATLVLAFLMICENMTLVEAIQTVQAHRNICPNSGFLRQLQVLDNRLGRE 194
>gi|56117822 testis and skeletal muscle-specific dual specificity
phosphatase isoform 3 [Homo sapiens]
Length = 291
Score = 149 bits (376), Expect = 2e-35
Identities = 80/175 (45%), Positives = 115/175 (65%), Gaps = 2/175 (1%)
Query: 108 SLYNTPCVLDLQRALVQDRQEAPWNEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAA 167
S Y P + LQR L+ RQ A N +DEVWP++F+ + A +K +L +LGITH++NAA
Sbjct: 114 SPYQPPTLASLQR-LLWVRQAATLNHIDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAA 172
Query: 168 HGT-GVYTGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSE 226
G V TG +FY G+ ++Y G+E DD P D+S +F + ++ AL +G+VLV
Sbjct: 173 AGKFQVDTGAKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVPQGRVLVHCA 232
Query: 227 MGISRSAVLVVAYLMIFHNMAILEALMTVRKKRAIYPNEGFLKQLRELNEKLMEE 281
MG+SRSA LV+A+LMI NM ++EA+ TV+ R I PN GFL+QL+ L+ +L E
Sbjct: 233 MGVSRSATLVLAFLMICENMTLVEAIQTVQAHRNICPNSGFLRQLQVLDNRLGRE 287
>gi|13128968 dual specificity phosphatase 26 [Homo sapiens]
Length = 211
Score = 147 bits (372), Expect = 4e-35
Identities = 76/169 (44%), Positives = 111/169 (65%), Gaps = 3/169 (1%)
Query: 115 VLDLQRALVQDRQEAPWNEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYT 174
V +L+R L + N DEVWP +++ ++ +A N+ L+RLGITH+LNA+H T
Sbjct: 45 VFELERLLYTGKTAC--NHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGT 102
Query: 175 GPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAV 234
PE Y GL I+YLGVE D P D+S HF+ A++F+ AL GK+LV +G+SRSA
Sbjct: 103 -PEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSAT 161
Query: 235 LVVAYLMIFHNMAILEALMTVRKKRAIYPNEGFLKQLRELNEKLMEERE 283
LV+AYLM++H++ ++EA+ V+ R I PN GFL+QL L+ +L + E
Sbjct: 162 LVLAYLMLYHHLTLVEAIKKVKDHRGIIPNRGFLRQLLALDRRLRQGLE 210
>gi|56117818 muscle-restricted dual specificity phosphatase isoform
1 [Homo sapiens]
Length = 188
Score = 144 bits (363), Expect = 5e-34
Identities = 79/171 (46%), Positives = 114/171 (66%), Gaps = 8/171 (4%)
Query: 112 TPC--VLDLQRALVQDRQEAPWNEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHG 169
TPC +L+L+ L + + VDEVWPN+FI + + A N+ L +LGITH+LNAAH
Sbjct: 16 TPCPSILELEELLRAGKSSC--SRVDEVWPNLFIGDAATANNRFELWKLGITHVLNAAH- 72
Query: 170 TGVYT--GPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEM 227
G+Y GP+FY G + YLGV D P+ DIS +F A++F+ AL T KVLV +
Sbjct: 73 KGLYCQGGPDFY-GSSVSYLGVPAHDLPDFDISAYFSSAADFIHRALNTPGAKVLVHCVV 131
Query: 228 GISRSAVLVVAYLMIFHNMAILEALMTVRKKRAIYPNEGFLKQLRELNEKL 278
G+SRSA LV+AYLM+ +++ +A++TVR+ R ++PN GFL QL L+++L
Sbjct: 132 GVSRSATLVLAYLMLHQRLSLRQAVITVRQHRWVFPNRGFLHQLCRLDQQL 182
>gi|4758208 dual specificity phosphatase 3 [Homo sapiens]
Length = 185
Score = 125 bits (315), Expect = 2e-28
Identities = 67/155 (43%), Positives = 97/155 (62%), Gaps = 3/155 (1%)
Query: 130 PWNEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTG---VYTGPEFYTGLEIQY 186
P +EV P +++ SVA + +L++LGITH+LNAA G V T FY I Y
Sbjct: 26 PSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITY 85
Query: 187 LGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNM 246
LG++ +D E ++S +F +A++F+D+AL G+VLV G SRS LV+AYLM+ M
Sbjct: 86 LGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKM 145
Query: 247 AILEALMTVRKKRAIYPNEGFLKQLRELNEKLMEE 281
+ AL VR+ R I PN+GFL QL +LN++L +E
Sbjct: 146 DVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKE 180
>gi|5902002 dual specificity phosphatase 14 [Homo sapiens]
Length = 198
Score = 76.3 bits (186), Expect = 2e-13
Identities = 54/164 (32%), Positives = 84/164 (51%), Gaps = 10/164 (6%)
Query: 118 LQRALVQDRQ--EAPWNEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTG 175
L R L+ R E + ++ ++F+ SVA N+ L+ GIT I+NA +
Sbjct: 9 LPRTLMAPRMISEGDIGGIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNW 68
Query: 176 PEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVL 235
P+F +Y+ V + D P I +F ++ + ++ G LV G+SRSA L
Sbjct: 69 PQF------EYVKVPLADMPHAPIGLYFDTVADKI-HSVSRKHGATLVHCAAGVSRSATL 121
Query: 236 VVAYLMIFHNMAILEALMTVRKKR-AIYPNEGFLKQLRELNEKL 278
+AYLM FHN+ +LEA V+ +R I PN GF +QL + +L
Sbjct: 122 CIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL 165
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 73.6 bits (179), Expect = 1e-12
Identities = 170/872 (19%), Positives = 282/872 (32%), Gaps = 91/872 (10%)
Query: 281 EREEDYGREG-----------GSAEAEEGEGTGSMLGARVHALTVEEEDDSASHLSGSSL 329
E +ED G+ G G EG G S G +V + +S + S
Sbjct: 397 EGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFD 456
Query: 330 GKATQASKPLTLI-----DEEEEEKLYEQWKKGQGLLSDKVPQDGGGWRSASSGQGGEEL 384
K+ Q P + D+ E +G + +D G + S +G E+
Sbjct: 457 DKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNG---NGSDSKGAEDD 513
Query: 385 EDEDVERIIQEWQSRNERYQAEGYRRWGREEEKEEESDAGSSVGRRRRTLSESSAWESVS 444
+ + + N + + + K + SD+ SS S+SS +S
Sbjct: 514 DSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSD 573
Query: 445 SHDIWVLKQQLELNRPDHGRRRRADSMSSESTWDAWNERLLEIEKEASRRYHAKSKREEA 504
S+ + + D +DS SS+S+ + + + + + SK + +
Sbjct: 574 SNS------SSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSS 627
Query: 505 ADRSSEAGSRVREDDEDSVGSEASSFYNFCSRNKDKLTALERWKIKRIQFGFHKKDLGAG 564
S + S + D DS S++S N D +
Sbjct: 628 KSESDSSDSDSKSDSSDSNSSDSSD-------NSD-----------------------SS 657
Query: 565 DSSGEPGAEEAVGEKNPSDVSLTAYQAWKLKHQKKVGSENKEEVVELSKGEDSALAKKRQ 624
DSS + ++ + SD S ++ + S N E + S DS +
Sbjct: 658 DSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSD 717
Query: 625 RRLELLERSRQTLEESQSMASWEADSSTASGSIPLSAFWSADPSVSADGDTTSVLSTQSH 684
S + S +S +DSS +S S S+D S S+D +S S S
Sbjct: 718 SSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSN-----SSDSSDSSDSSNSSDSSDSSD 772
Query: 685 RSHLSQAASNIAGCSTSNPTTPLPNLPVGPGDTISIASIQNWIANVVSETLAQKQNEMLL 744
S S ++++ +SN + + S +S + ++ S + N
Sbjct: 773 SSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNS--- 829
Query: 745 LSRSPSVASMKAVPAASCLGDDQVSMLSGHSSSSLGGCLLPQSQARPSSDMQSVLSCNTT 804
S S ++ +S D S S S SS S + SSD N +
Sbjct: 830 -SDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNES 888
Query: 805 LSSPAESCRSKVRGTSKPIFSLFADNVDLKELGRKEKEMQMELREKMSEYKMEKLASDNK 864
+S S S + S +D+ D S+ +SDN
Sbjct: 889 SNSSDSSDSSNSSDSDSSDSSNSSDSSD---------------SSNSSDSSESSNSSDNS 933
Query: 865 RSSLFKKKKVKEDEDDGVGDGDEDTDSAIGSFRYSSRSNSQKPETDTCSSLAVCDHYASG 924
SS D D D S + SS SNS + SS
Sbjct: 934 NSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSS--------DS 985
Query: 925 SRVGKEMDSSINKWLSGLRTEEKPPFQSDWSGSSRGKYTRSSLLRETESKSSSYKFSKSQ 984
S DSS + S SD S SS + S S SS S
Sbjct: 986 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDS 1045
Query: 985 SEEQDTSSYHEANGNSVRSTSRFSSSSTREGREMHKFSRSTYNETSSSREESPEPYFFRR 1044
S+ D+S ++ +S S S SS S+ S +++S+S + S
Sbjct: 1046 SDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDS 1105
Query: 1045 TPESSEREESPEPQRPNWARSRDWEDVEESSKSDFSEFGAKRKFTQSFMRSEEEGEKERT 1104
+ S + S N + S D D +SS S S + + S + + +
Sbjct: 1106 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDS 1165
Query: 1105 ENREEGRFASGRRSQYRRSTDREEEEEMDDEA 1136
+ + S S S+D + + D +
Sbjct: 1166 SDSSD----SSDSSDSSNSSDSSDSSDSSDSS 1193
Score = 68.6 bits (166), Expect = 3e-11
Identities = 155/801 (19%), Positives = 270/801 (33%), Gaps = 53/801 (6%)
Query: 364 KVPQDGGGWRSASSGQGGEELEDEDVERIIQEWQSRNERYQAEGYRRWGREEEKEEESDA 423
K P G + G+G E ED+ +I N + Q E G ++ E +
Sbjct: 379 KGPSSGNRNITKEVGKGNEGKEDKGQHGMILG--KGNVKTQGEVVNIEGPGQKSEPGNKV 436
Query: 424 GSSVGRRRRTLSESSAWESVSSHDIWVLKQQLELNRPDHGRRRRADSMSSESTWDAWNER 483
G S T S+S++ + S+D + + D +S + ++
Sbjct: 437 GHS-----NTGSDSNS-DGYDSYDF-------------DDKSMQGDDPNSSDESNGNDDA 477
Query: 484 LLEIEKEASRRYHAKSKREEAADRSSEAGSRVREDDE-DSVGSEASSFYNFCSRN-KDKL 541
E + +S R A +E+ D + + S+ EDD+ DS +S N N D
Sbjct: 478 NSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDN 537
Query: 542 TALERWKIKRIQFGFHKKDLGAGDSSGEPGAEEAVGEKNPSDVSLTAYQAWKLKHQKKVG 601
+ K K D S + ++ + SD + +
Sbjct: 538 DKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSD 597
Query: 602 SENKEEVVELSKGEDSALAKKRQRRLELLERSRQTLEESQSMA-------------SWEA 648
S N + + S DS+ + +S +S S + S +
Sbjct: 598 SSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSS 657
Query: 649 DSSTASGSIPLS-AFWSADPSVSADGDTTSVLSTQSHRSHLSQAA----------SNIAG 697
DSS +S S S + S+D S S+D +S S S S+ S+++ S+ +
Sbjct: 658 DSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSD 717
Query: 698 CSTSNPTTPLPNLPVGPGDTISIASIQNWIANVVSETLAQKQNEMLLLSRSPSVASMKAV 757
S SN + + D+ + + + + S + + S S S +
Sbjct: 718 SSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSS 777
Query: 758 PAASCLGDDQVSMLSGHSSSSLGGCLLPQSQARPSSDMQSVLSCNTTLSSPAESCRSKVR 817
+++ + S S S SS S + SSD S N++ SS +
Sbjct: 778 DSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSN 837
Query: 818 GTSKPIFSLFADNVDLKELGRKEKEMQMELREKMSEYKMEKLASDNKRSSLFKKKKVKED 877
+ S +D D R + + S+ +SD+ SS + D
Sbjct: 838 SSDSSDSSDSSDGSDSDSSNRSDSSNSSD----SSDSSDSSNSSDSSDSSDSNESSNSSD 893
Query: 878 EDDGVGDGDEDTDSAIGSFRYSSRSNSQKPETDTCSSLAVCDHYASGSRVGKEMDSSINK 937
D D D+ + S S SNS + SS +S S + S N
Sbjct: 894 SSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNS 953
Query: 938 WLSGLRTEEKPPFQSDWSGSSRGKYTRSSLLRETESKSSSYKFSKSQSEEQDTSSYHEAN 997
S ++ S S SS + +S S SS S S D+S +++
Sbjct: 954 SDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1013
Query: 998 GNSVRSTSRFSSSSTREGREMHKFSRSTYNETSSSREESPEPYFFRRTPESSEREESPEP 1057
+S S S SS S+ S +++S S + S + S + S
Sbjct: 1014 DSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1073
Query: 1058 QRPNWARSRDWEDVEESSKSDFSEFGAKRKFTQSFMRSEEEGEKERTENREEGRFA--SG 1115
+ + S + D +SS S S + + S + + + N + + S
Sbjct: 1074 DSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1133
Query: 1116 RRSQYRRSTDREEEEEMDDEA 1136
S S+D + E D +
Sbjct: 1134 DSSDSSNSSDSSDSSESSDSS 1154
Score = 62.4 bits (150), Expect = 2e-09
Identities = 126/611 (20%), Positives = 217/611 (35%), Gaps = 44/611 (7%)
Query: 468 ADSMSSESTWDAWNERLLEIEKEASRRYHAKSKREEAADRSSEAGSRVREDDEDSVGSEA 527
+DS SS+S+ D+ N + + S S +++D S + S D DS S
Sbjct: 708 SDSDSSDSS-DSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSD 766
Query: 528 SSFYNFCSRNKDKLTALERWKIKRIQFGFHKKDLGAGDSSGEPGAEEAVGEKNPSDVSLT 587
SS + S + D + + + DSS + ++ + SD S +
Sbjct: 767 SSDSSDSSDSSDSSNSSDS-----------NDSSNSSDSSDSSNSSDSSNSSDSSDSSDS 815
Query: 588 AYQAWKLKHQKKVGSENKEEVVELSKGEDSALAKKRQRRLELLERSRQTLEESQSMASWE 647
+ S N + + S DS+ S + + S S +S
Sbjct: 816 SDS----DSSNSSDSSNSSDSSDSSNSSDSS-------------DSSDSSDGSDSDSSNR 858
Query: 648 ADSSTASGSIPLSAFWSADPSVSADGDTTSVLSTQSHRSHLSQAASNIAGCSTSNPTTPL 707
+DSS +S S S+D S S+D +S S +S S S +SN + +S+ +
Sbjct: 859 SDSSNSSDSSD-----SSDSSNSSDSSDSSD-SNESSNSSDSSDSSNSSDSDSSDSSNSS 912
Query: 708 PNLPVGPGDTISIASIQNWIANVVSETLAQKQNEMLLLSRSPSVASMKAVPAASCLGDDQ 767
+ S +S + +N + + ++ S S ++ +S D
Sbjct: 913 DSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSN 972
Query: 768 VSMLSGHSSSSLGGCLLPQSQARPSSDMQ-SVLSCNTTLSSPAESCRSKVRGTSKPIFSL 826
S S S+SS S + SSD S S +++ SS + + + S
Sbjct: 973 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSD 1032
Query: 827 FADNVDLKELGRKEKEMQMELREKMSEYKMEKLASDNKRSSLFKKKKVKEDEDDGVGDGD 886
+D+ D + S+ +SD+ SS + D D
Sbjct: 1033 SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDS-SDSS 1091
Query: 887 EDTDSAIGSFRYSSRSNSQKPETDTCSSLAVCDHYASGSRVGKEMDSSINKWLSGLRTEE 946
+DS+ S S +S ++ S + + S DSS + S
Sbjct: 1092 NSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESS 1151
Query: 947 KPPFQSDWSGSSRGKYTRSSLLRETESKSSSYKFSKSQSEEQDTSSYHEANGNSVRSTSR 1006
SD S SS + S S SS S S+ D+S +++ +S S S
Sbjct: 1152 DSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1211
Query: 1007 FSSSSTREGREMHKFSRSTYNETSSSREESPEPYFFRRTPESSEREESPEPQRPNWARSR 1066
SS S+ S NE+S S + S + +SS +S + + + S
Sbjct: 1212 DSSDSSDSSDSSDSSDSSDSNESSDSSDSSD-------SSDSSNSSDSSDSSDSSDSTSD 1264
Query: 1067 DWEDVEESSKS 1077
++ + SKS
Sbjct: 1265 SNDESDSQSKS 1275
>gi|4503417 dual specificity phosphatase 4 isoform 1 [Homo sapiens]
Length = 394
Score = 73.2 bits (178), Expect = 1e-12
Identities = 49/145 (33%), Positives = 80/145 (55%), Gaps = 8/145 (5%)
Query: 136 EVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEVDDFP 195
E+ P +++ A + L LGIT +LN + P + G QY + V+D
Sbjct: 198 EILPFLYLGSAYHAARRDMLDALGITALLNVSSDC-----PNHFEG-HYQYKCIPVEDNH 251
Query: 196 EVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTV 255
+ DIS F +A E++D A+ RG+VLV + GISRSA + +AYLM+ + + EA V
Sbjct: 252 KADISSWFMEAIEYID-AVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFV 310
Query: 256 RKKRAIY-PNEGFLKQLRELNEKLM 279
+++R+I PN F+ QL + +++
Sbjct: 311 KQRRSIISPNFSFMGQLLQFESQVL 335
>gi|16950652 dual specificity phosphatase 4 isoform 2 [Homo sapiens]
Length = 303
Score = 73.2 bits (178), Expect = 1e-12
Identities = 49/145 (33%), Positives = 80/145 (55%), Gaps = 8/145 (5%)
Query: 136 EVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEVDDFP 195
E+ P +++ A + L LGIT +LN + P + G QY + V+D
Sbjct: 107 EILPFLYLGSAYHAARRDMLDALGITALLNVSSDC-----PNHFEG-HYQYKCIPVEDNH 160
Query: 196 EVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTV 255
+ DIS F +A E++D A+ RG+VLV + GISRSA + +AYLM+ + + EA V
Sbjct: 161 KADISSWFMEAIEYID-AVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFV 219
Query: 256 RKKRAIY-PNEGFLKQLRELNEKLM 279
+++R+I PN F+ QL + +++
Sbjct: 220 KQRRSIISPNFSFMGQLLQFESQVL 244
>gi|4503421 dual specificity phosphatase 9 [Homo sapiens]
Length = 384
Score = 72.4 bits (176), Expect = 2e-12
Identities = 54/163 (33%), Positives = 82/163 (50%), Gaps = 9/163 (5%)
Query: 136 EVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYT-GLEIQYLGVEVDDF 194
++ PN+++ + N L +LGI +ILN P F+ + Y + + D
Sbjct: 206 QILPNLYLGSARDSANLESLAKLGIRYILNVTPNL-----PNFFEKNGDFHYKQIPISDH 260
Query: 195 PEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEAL-M 253
++S+ F +A EF+DEAL G VLV G+SRS + VAYLM ++++ +A +
Sbjct: 261 WSQNLSRFFPEAIEFIDEALSQNCG-VLVHCLAGVSRSVTVTVAYLMQKLHLSLNDAYDL 319
Query: 254 TVRKKRAIYPNEGFLKQLRELNEKL-MEEREEDYGREGGSAEA 295
RKK I PN F+ QL + L +EER GG A A
Sbjct: 320 VKRKKSNISPNFNFMGQLLDFERSLRLEERHSQEQGSGGQASA 362
>gi|4758204 dual specificity phosphatase 1 [Homo sapiens]
Length = 367
Score = 69.7 bits (169), Expect = 2e-11
Identities = 53/190 (27%), Positives = 93/190 (48%), Gaps = 9/190 (4%)
Query: 136 EVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEVDDFP 195
E+ P +++ A K L LGIT ++N + P + G QY + V+D
Sbjct: 176 EILPFLYLGSAYHASRKDMLDALGITALINVSANC-----PNHFEG-HYQYKSIPVEDNH 229
Query: 196 EVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTV 255
+ DIS F +A +F+D ++ G+V V + GISRSA + +AYLM + + + EA V
Sbjct: 230 KADISSWFNEAIDFID-SIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFV 288
Query: 256 RKKRAIY-PNEGFLKQLRELNEKLMEEREEDYGREGGSAEAEEGEGTGSMLGARVHALTV 314
+++R+I PN F+ QL + +++ A + G T ++ V ++ V
Sbjct: 289 KQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPV-SIPV 347
Query: 315 EEEDDSASHL 324
+ + S+L
Sbjct: 348 HSTNSALSYL 357
>gi|18254478 dual specificity phosphatase 19 isoform 1 [Homo
sapiens]
Length = 217
Score = 69.7 bits (169), Expect = 2e-11
Identities = 46/145 (31%), Positives = 73/145 (50%), Gaps = 8/145 (5%)
Query: 133 EVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEVD 192
+V + P + + + A + LK+ +THILN A+G +F Y + +
Sbjct: 65 QVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDF------TYKSISIL 118
Query: 193 DFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEAL 252
D PE +I +F + EF++EA G VLV G+SR+A +V+ +LM + A
Sbjct: 119 DLPETNILSYFPECFEFIEEAKRK-DGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAF 177
Query: 253 MTVRKKR-AIYPNEGFLKQLRELNE 276
V+ R +I PN GF++QLR E
Sbjct: 178 SLVKNARPSICPNSGFMEQLRTYQE 202
>gi|239750646 PREDICTED: hypothetical protein XP_002347464 [Homo
sapiens]
Length = 223
Score = 68.9 bits (167), Expect = 3e-11
Identities = 51/145 (35%), Positives = 76/145 (52%), Gaps = 7/145 (4%)
Query: 133 EVDEVWPNVFIAEKSVAVNKGR--LKRLGITHILNAAHGTGV-YTGPEFYTGLEIQYLGV 189
E+ E+ P +F+ S A+ L++ GITHI+ + P F +YL +
Sbjct: 28 EMQEILPGLFLGPYSSAMKSKLPVLQKHGITHIICIRQNIEANFIKPNFQQ--LFRYLVL 85
Query: 190 EVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAIL 249
++ D P +I + F EF+D +L GKVLV GISRSA V+AY+M M
Sbjct: 86 DIADNPVENIIRFFPMTKEFIDGSL-QMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYR 144
Query: 250 EALMTVRKKR-AIYPNEGFLKQLRE 273
+A V+++R I PN GF+ QL+E
Sbjct: 145 DAFAYVQERRFCINPNAGFVHQLQE 169
>gi|194733759 serine/threonine/tyrosine interacting protein [Homo
sapiens]
Length = 223
Score = 68.9 bits (167), Expect = 3e-11
Identities = 51/145 (35%), Positives = 76/145 (52%), Gaps = 7/145 (4%)
Query: 133 EVDEVWPNVFIAEKSVAVNKGR--LKRLGITHILNAAHGTGV-YTGPEFYTGLEIQYLGV 189
E+ E+ P +F+ S A+ L++ GITHI+ + P F +YL +
Sbjct: 28 EMQEILPGLFLGPYSSAMKSKLPVLQKHGITHIICIRQNIEANFIKPNFQQ--LFRYLVL 85
Query: 190 EVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAIL 249
++ D P +I + F EF+D +L GKVLV GISRSA V+AY+M M
Sbjct: 86 DIADNPVENIIRFFPMTKEFIDGSL-QMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYR 144
Query: 250 EALMTVRKKR-AIYPNEGFLKQLRE 273
+A V+++R I PN GF+ QL+E
Sbjct: 145 DAFAYVQERRFCINPNAGFVHQLQE 169
>gi|21687043 serine/threonine/tyrosine interacting protein [Homo
sapiens]
Length = 223
Score = 68.9 bits (167), Expect = 3e-11
Identities = 51/145 (35%), Positives = 76/145 (52%), Gaps = 7/145 (4%)
Query: 133 EVDEVWPNVFIAEKSVAVNKGR--LKRLGITHILNAAHGTGV-YTGPEFYTGLEIQYLGV 189
E+ E+ P +F+ S A+ L++ GITHI+ + P F +YL +
Sbjct: 28 EMQEILPGLFLGPYSSAMKSKLPVLQKHGITHIICIRQNIEANFIKPNFQQ--LFRYLVL 85
Query: 190 EVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAIL 249
++ D P +I + F EF+D +L GKVLV GISRSA V+AY+M M
Sbjct: 86 DIADNPVENIIRFFPMTKEFIDGSL-QMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYR 144
Query: 250 EALMTVRKKR-AIYPNEGFLKQLRE 273
+A V+++R I PN GF+ QL+E
Sbjct: 145 DAFAYVQERRFCINPNAGFVHQLQE 169
>gi|9910432 dual specificity phosphatase 22 [Homo sapiens]
Length = 184
Score = 67.4 bits (163), Expect = 8e-11
Identities = 51/179 (28%), Positives = 92/179 (51%), Gaps = 13/179 (7%)
Query: 132 NEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLE-IQYLGVE 190
N ++++ P ++I A + +L + +THIL+ LE ++YL +
Sbjct: 3 NGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPM--------LEGVKYLCIP 54
Query: 191 VDDFPEVDISQHFRKASEFLDEALLTYRGK-VLVSSEMGISRSAVLVVAYLMIFHNMAIL 249
D P ++++HF+++ +F+ E L RG+ LV G+SRS LV+AY+M +
Sbjct: 55 AADSPSQNLTRHFKESIKFIHECRL--RGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWE 112
Query: 250 EALMTVRKKRA-IYPNEGFLKQLRELNEKLMEEREEDYGREGGSAEAEEGEGTGSMLGA 307
+AL TVR R+ PN GF +QL+E + + + + E G + ++ E ++L A
Sbjct: 113 DALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQWLKEEYGESPLQDAEEAKNILAA 171
>gi|6005812 dual specificity phosphatase 10 isoform a [Homo sapiens]
Length = 482
Score = 67.0 bits (162), Expect = 1e-10
Identities = 46/147 (31%), Positives = 78/147 (53%), Gaps = 6/147 (4%)
Query: 133 EVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEVD 192
E+ + P +F+ + A + ++RL I +++N +Y + GL Y +
Sbjct: 321 ELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLY---HYEKGL-FNYKRLPAT 376
Query: 193 DFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEAL 252
D + ++ Q+F +A EF++EA +G +L+ + G+SRSA +V+AYLM M + +A
Sbjct: 377 DSNKQNLRQYFEEAFEFIEEAHQCGKG-LLIHCQAGVSRSATIVIAYLMKHTRMTMTDAY 435
Query: 253 MTVRKKRAIY-PNEGFLKQLRELNEKL 278
V+ KR I PN F+ QL E E L
Sbjct: 436 KFVKGKRPIISPNLNFMGQLLEFEEDL 462
>gi|29826315 dual specificity phosphatase 15 isoform a [Homo
sapiens]
Length = 235
Score = 66.6 bits (161), Expect = 1e-10
Identities = 53/170 (31%), Positives = 82/170 (48%), Gaps = 13/170 (7%)
Query: 132 NEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEV 191
N + +V P +++ A + +L R ITHI++ ++ P+ +I YL + V
Sbjct: 3 NGMTKVLPGLYLGNFIDAKDLDQLGRNKITHIIS------IHESPQPLLQ-DITYLRIPV 55
Query: 192 DDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEA 251
D PEV I +HF++ F+ L G LV GISRS +V AY+M + +
Sbjct: 56 ADTPEVPIKKHFKECINFIHCCRLN-GGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDV 114
Query: 252 LMTVRKKRAI-YPNEGFLKQLREL----NEKLMEEREEDYGREGGSAEAE 296
L ++ R I PN GF +QL E ++KL + EE +G E E
Sbjct: 115 LEAIKATRPIANPNPGFRQQLEEFGWASSQKLRRQLEERFGESPFRDEEE 164
>gi|239047498 slingshot 1 isoform 3 [Homo sapiens]
Length = 703
Score = 66.2 bits (160), Expect = 2e-10
Identities = 94/406 (23%), Positives = 163/406 (40%), Gaps = 58/406 (14%)
Query: 84 MLESAEQLLVEDLYNRVREKMDDTSLYNTPCVLDLQRALVQDRQEAPWNEVDEVWPNVFI 143
M + E + +++ N + ++M+ +L +D + L+ + + P ++ ++++
Sbjct: 275 MSQDLENVTSKEIRNELEKQMN-CNLKELKEFIDNEMLLILGQMDKP----SLIFDHLYL 329
Query: 144 AEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEVDDFPEVDISQHF 203
+ A N L+ G+ +ILN F+ GL Y + V D D+ H+
Sbjct: 330 GSEWNASNLEELQGSGVDYILNVTREID-----NFFPGL-FAYHNIRVYDEETTDLLAHW 383
Query: 204 RKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTVRKKRAI-Y 262
+A F+++A + K LV +MG+SRSA V+AY M + +A V++KR+I
Sbjct: 384 NEAYHFINKAKRNH-SKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAYNYVKQKRSITR 442
Query: 263 PNEGFLKQLRELNEKL--MEEREEDYGREGGSAE----AEEGEGTGSMLGARVHALTVEE 316
PN GF++QL E L ++R R+ + ++ G G L T E
Sbjct: 443 PNAGFMRQLSEYEGILDASKQRHNKLWRQQTDSSLQQPVDDPAGPGDFLPETPDG-TPES 501
Query: 317 E----DDSASHLSGSSLGKA-TQASKPLTLIDEEEEEKLYEQWKKGQGLLSDKVPQDGGG 371
+ DD+A G L + S PL E+E L + L ++
Sbjct: 502 QLPFLDDAAQPGLGPPLPCCFRRLSDPLLPSPEDETGSLVHLEDPEREALLEEAAPPAEV 561
Query: 372 WRSASSGQGGEELEDEDVERIIQEWQSR-----------NERYQAEGYRRWGR------- 413
R A Q G L ++DV++ ++ + ER + G RWG+
Sbjct: 562 HRPARQPQQGSGLCEKDVKKKLEFGSPKGRSGSLLQVEETEREEGLGAGRWGQLPTQLDQ 621
Query: 414 --------EEEKEEESDAGSSVGRRRRTLSESSAWE--SVSSHDIW 449
+ G VGR R + W S+ SH W
Sbjct: 622 NLLNSENLNNNSKRSCPNGMEVGRAR-----PAGWHTPSLPSHSNW 662
>gi|239047441 slingshot 1 isoform 2 [Homo sapiens]
Length = 692
Score = 66.2 bits (160), Expect = 2e-10
Identities = 94/406 (23%), Positives = 163/406 (40%), Gaps = 58/406 (14%)
Query: 84 MLESAEQLLVEDLYNRVREKMDDTSLYNTPCVLDLQRALVQDRQEAPWNEVDEVWPNVFI 143
M + E + +++ N + ++M+ +L +D + L+ + + P ++ ++++
Sbjct: 264 MSQDLENVTSKEIRNELEKQMN-CNLKELKEFIDNEMLLILGQMDKP----SLIFDHLYL 318
Query: 144 AEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEVDDFPEVDISQHF 203
+ A N L+ G+ +ILN F+ GL Y + V D D+ H+
Sbjct: 319 GSEWNASNLEELQGSGVDYILNVTREID-----NFFPGL-FAYHNIRVYDEETTDLLAHW 372
Query: 204 RKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTVRKKRAI-Y 262
+A F+++A + K LV +MG+SRSA V+AY M + +A V++KR+I
Sbjct: 373 NEAYHFINKAKRNH-SKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAYNYVKQKRSITR 431
Query: 263 PNEGFLKQLRELNEKL--MEEREEDYGREGGSAE----AEEGEGTGSMLGARVHALTVEE 316
PN GF++QL E L ++R R+ + ++ G G L T E
Sbjct: 432 PNAGFMRQLSEYEGILDASKQRHNKLWRQQTDSSLQQPVDDPAGPGDFLPETPDG-TPES 490
Query: 317 E----DDSASHLSGSSLGKA-TQASKPLTLIDEEEEEKLYEQWKKGQGLLSDKVPQDGGG 371
+ DD+A G L + S PL E+E L + L ++
Sbjct: 491 QLPFLDDAAQPGLGPPLPCCFRRLSDPLLPSPEDETGSLVHLEDPEREALLEEAAPPAEV 550
Query: 372 WRSASSGQGGEELEDEDVERIIQEWQSR-----------NERYQAEGYRRWGR------- 413
R A Q G L ++DV++ ++ + ER + G RWG+
Sbjct: 551 HRPARQPQQGSGLCEKDVKKKLEFGSPKGRSGSLLQVEETEREEGLGAGRWGQLPTQLDQ 610
Query: 414 --------EEEKEEESDAGSSVGRRRRTLSESSAWE--SVSSHDIW 449
+ G VGR R + W S+ SH W
Sbjct: 611 NLLNSENLNNNSKRSCPNGMEVGRAR-----PAGWHTPSLPSHSNW 651
>gi|239047414 slingshot 1 isoform 1 [Homo sapiens]
Length = 1049
Score = 65.9 bits (159), Expect = 2e-10
Identities = 84/353 (23%), Positives = 150/353 (42%), Gaps = 36/353 (10%)
Query: 84 MLESAEQLLVEDLYNRVREKMDDTSLYNTPCVLDLQRALVQDRQEAPWNEVDEVWPNVFI 143
M + E + +++ N + ++M+ +L +D + L+ + + P ++ ++++
Sbjct: 264 MSQDLENVTSKEIRNELEKQMN-CNLKELKEFIDNEMLLILGQMDKP----SLIFDHLYL 318
Query: 144 AEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEVDDFPEVDISQHF 203
+ A N L+ G+ +ILN F+ GL Y + V D D+ H+
Sbjct: 319 GSEWNASNLEELQGSGVDYILNVTREID-----NFFPGL-FAYHNIRVYDEETTDLLAHW 372
Query: 204 RKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTVRKKRAI-Y 262
+A F+++A + K LV +MG+SRSA V+AY M + +A V++KR+I
Sbjct: 373 NEAYHFINKAKRNH-SKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAYNYVKQKRSITR 431
Query: 263 PNEGFLKQLRELNEKL--MEEREEDYGREGGSAE----AEEGEGTGSMLGARVHALTVEE 316
PN GF++QL E L ++R R+ + ++ G G L T E
Sbjct: 432 PNAGFMRQLSEYEGILDASKQRHNKLWRQQTDSSLQQPVDDPAGPGDFLPETPDG-TPES 490
Query: 317 E----DDSASHLSGSSLGKA-TQASKPLTLIDEEEEEKLYEQWKKGQGLLSDKVPQDGGG 371
+ DD+A G L + S PL E+E L + L ++
Sbjct: 491 QLPFLDDAAQPGLGPPLPCCFRRLSDPLLPSPEDETGSLVHLEDPEREALLEEAAPPAEV 550
Query: 372 WRSASSGQGGEELEDEDVERIIQEWQSR-----------NERYQAEGYRRWGR 413
R A Q G L ++DV++ ++ + ER + G RWG+
Sbjct: 551 HRPARQPQQGSGLCEKDVKKKLEFGSPKGRSGSLLQVEETEREEGLGAGRWGQ 603
>gi|62865890 dual specificity phosphatase 5 [Homo sapiens]
Length = 384
Score = 65.9 bits (159), Expect = 2e-10
Identities = 51/179 (28%), Positives = 83/179 (46%), Gaps = 14/179 (7%)
Query: 136 EVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEVDDFP 195
E+ P +++ A L L IT +LN + T + Y + V+D
Sbjct: 181 EILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLH------YKWIPVEDSH 234
Query: 196 EVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTV 255
DIS HF++A +F+D + GKVLV E GISRS + +AYLM + EA +
Sbjct: 235 TADISSHFQEAIDFID-CVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYI 293
Query: 256 RKKRA-IYPNEGFLKQLRELNEKLMEEREEDYGREGGSAEAEEGEGTGSMLGARVHALT 313
+++R+ + PN GF+ QL + +++ + +GE GS L + L+
Sbjct: 294 KQRRSMVSPNFGFMGQLLQYESEILPSTPNP------QPPSCQGEAAGSSLIGHLQTLS 346
>gi|239582767 slingshot homolog 3 [Homo sapiens]
Length = 659
Score = 64.7 bits (156), Expect = 5e-10
Identities = 51/168 (30%), Positives = 84/168 (50%), Gaps = 9/168 (5%)
Query: 132 NEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEV 191
+ ++P++++ + A N L+R +THILN A + PE +T Y V +
Sbjct: 327 DRASRIFPHLYLGSEWNAANLEELQRNRVTHILNMAREIDNFY-PERFT-----YHNVRL 380
Query: 192 DDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEA 251
D + H+++ F+ EA VLV +MG+SRSA V+AY M + ++ +A
Sbjct: 381 WDEESAQLLPHWKETHRFI-EAARAQGTHVLVHCKMGVSRSAATVLAYAMKQYECSLEQA 439
Query: 252 LMTVRKKRAI-YPNEGFLKQLRELNEKLMEEREED-YGREGGSAEAEE 297
L V++ R I PN GFL+QL+ L R+ + ++ G EE
Sbjct: 440 LRHVQELRPIARPNPGFLRQLQIYQGILTASRQSHVWEQKVGGVSPEE 487
>gi|4758206 dual specificity phosphatase 2 [Homo sapiens]
Length = 314
Score = 63.5 bits (153), Expect = 1e-09
Identities = 47/145 (32%), Positives = 78/145 (53%), Gaps = 8/145 (5%)
Query: 136 EVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEVDDFP 195
E+ P +F+ S + + L+ GIT +LN + P + GL +Y + V+D
Sbjct: 175 EILPYLFLGSCSHSSDLQGLQACGITAVLNVSASC-----PNHFEGL-FRYKSIPVEDNQ 228
Query: 196 EVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTV 255
V+IS F++A F+D + G+VLV + GISRSA + +AYLM + + EA V
Sbjct: 229 MVEISAWFQEAIGFIDW-VKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFV 287
Query: 256 RKKR-AIYPNEGFLKQLRELNEKLM 279
+++R I PN F+ QL + +++
Sbjct: 288 KQRRGVISPNFSFMGQLLQFETQVL 312
>gi|153281158 dual specificity phosphatase 8 [Homo sapiens]
Length = 625
Score = 63.5 bits (153), Expect = 1e-09
Identities = 54/191 (28%), Positives = 95/191 (49%), Gaps = 9/191 (4%)
Query: 118 LQRALVQDRQEAPWNEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPE 177
L +L Q P + + P++++ + +NK + + GI+++LNA++ P+
Sbjct: 145 LPMSLSQPCLPVPSVGLTRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSC---PKPD 201
Query: 178 FYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVV 237
F E +++ V ++D + K+ EF+D+A L+ +V+V GISRSA + +
Sbjct: 202 FIC--ESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLS-SCQVIVHCLAGISRSATIAI 258
Query: 238 AYLMIFHNMAILEALMTVRKKR-AIYPNEGFLKQLRELNE--KLMEEREEDYGREGGSAE 294
AY+M M+ +A V+ +R +I PN FL QL E KL+ + D G G+ E
Sbjct: 259 AYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSLKLLAALQGDPGTPSGTPE 318
Query: 295 AEEGEGTGSML 305
G+ L
Sbjct: 319 PPPSPAAGAPL 329
>gi|38372911 dual specificity phosphatase 16 [Homo sapiens]
Length = 665
Score = 61.6 bits (148), Expect = 4e-09
Identities = 47/146 (32%), Positives = 81/146 (55%), Gaps = 7/146 (4%)
Query: 137 VWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEVDDFPE 196
+ PN+++ + +NK +++ GI ++LNA++ P+F E +L V V+D
Sbjct: 162 ILPNLYLGCQRDVLNKELMQQNGIGYVLNASN---TCPKPDFIP--ESHFLRVPVNDSFC 216
Query: 197 VDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTVR 256
I K+ +F+++A + G VLV GISRSA + +AY+M +M++ EA V+
Sbjct: 217 EKILPWLDKSVDFIEKAKAS-NGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVK 275
Query: 257 KKR-AIYPNEGFLKQLRELNEKLMEE 281
+KR I PN FL QL + +K+ +
Sbjct: 276 EKRPTISPNFNFLGQLLDYEKKIKNQ 301
>gi|21536333 dual specificity phosphatase 10 isoform b [Homo
sapiens]
Length = 140
Score = 61.2 bits (147), Expect = 5e-09
Identities = 42/125 (33%), Positives = 68/125 (54%), Gaps = 6/125 (4%)
Query: 155 LKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEAL 214
++RL I +++N +Y + GL Y + D + ++ Q+F +A EF++EA
Sbjct: 1 MQRLNIGYVINVTTHLPLY---HYEKGL-FNYKRLPATDSNKQNLRQYFEEAFEFIEEAH 56
Query: 215 LTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTVRKKRAIY-PNEGFLKQLRE 273
+G +L+ + G+SRSA +V+AYLM M + +A V+ KR I PN F+ QL E
Sbjct: 57 QCGKG-LLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLE 115
Query: 274 LNEKL 278
E L
Sbjct: 116 FEEDL 120
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.124 0.344
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,434,852
Number of Sequences: 37866
Number of extensions: 2225847
Number of successful extensions: 17618
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 146
Number of HSP's successfully gapped in prelim test: 556
Number of HSP's that attempted gapping in prelim test: 11815
Number of HSP's gapped (non-prelim): 4344
length of query: 1158
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1045
effective length of database: 13,968,660
effective search space: 14597249700
effective search space used: 14597249700
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.