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Search of human proteins with 27734909
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27734909 kelch domain containing 8B [Homo sapiens]
(354 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27734909 kelch domain containing 8B [Homo sapiens] 729 0.0
gi|8922640 kelch domain containing 8A [Homo sapiens] 338 6e-93
gi|34101268 kelch-like 8 [Homo sapiens] 100 2e-21
gi|11056006 kelch-like 12 [Homo sapiens] 98 1e-20
gi|55925604 kelch-like 18 [Homo sapiens] 95 1e-19
gi|166235129 kelch-like 3 [Homo sapiens] 90 3e-18
gi|38194229 kelch-like 17 [Homo sapiens] 89 8e-18
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 87 3e-17
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 87 3e-17
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 87 3e-17
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 86 4e-17
gi|223890235 intracisternal A particle-promoted polypeptide isof... 86 4e-17
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 86 5e-17
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 86 5e-17
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 86 5e-17
gi|24475847 influenza virus NS1A binding protein [Homo sapiens] 86 7e-17
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 84 1e-16
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 84 1e-16
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 84 2e-16
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 84 2e-16
gi|40807500 kelch-like 20 [Homo sapiens] 84 2e-16
gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Hom... 83 4e-16
gi|14780904 kelch-like 1 protein [Homo sapiens] 82 6e-16
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 82 6e-16
gi|148664209 kelch-like 10 [Homo sapiens] 81 1e-15
gi|156616301 kelch-like 32 [Homo sapiens] 75 7e-14
gi|55741643 kelch-like 14 [Homo sapiens] 74 2e-13
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 74 2e-13
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 74 2e-13
gi|31542246 kelch-like 36 [Homo sapiens] 73 3e-13
>gi|27734909 kelch domain containing 8B [Homo sapiens]
Length = 354
Score = 729 bits (1881), Expect = 0.0
Identities = 354/354 (100%), Positives = 354/354 (100%)
Query: 1 MSAGGGRAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWL 60
MSAGGGRAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWL
Sbjct: 1 MSAGGGRAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWL 60
Query: 61 ALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGV 120
ALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGV
Sbjct: 61 ALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGV 120
Query: 121 ATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVL 180
ATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVL
Sbjct: 121 ATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVL 180
Query: 181 GGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYS 240
GGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYS
Sbjct: 181 GGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYS 240
Query: 241 RPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVE 300
RPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVE
Sbjct: 241 RPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVE 300
Query: 301 SFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQGPSQAVEALCLRDGV 354
SFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQGPSQAVEALCLRDGV
Sbjct: 301 SFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQGPSQAVEALCLRDGV 354
>gi|8922640 kelch domain containing 8A [Homo sapiens]
Length = 350
Score = 338 bits (866), Expect = 6e-93
Identities = 160/344 (46%), Positives = 224/344 (65%), Gaps = 3/344 (0%)
Query: 9 FAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTA 68
F W+ P+P+ RVY ++ G + +GGC G+P+D E + W AL LPTA
Sbjct: 9 FQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWTALPRLPTA 68
Query: 69 RAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGM 128
RAG A LGK+++V+GGV Q P+ VE + +DEG+W++R+ L +AAMG++ +D
Sbjct: 69 RAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYR 128
Query: 129 VYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLP 188
VYA GGMG D P ++ Y+ +D W+SL MPTP Y A++FL G+KIYVLGGRQ K
Sbjct: 129 VYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYA 188
Query: 189 VTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTV 248
V AFE FD+E R+WT+ P++P +RAF+ + ++SLGGL+Q Y +P F+ T+
Sbjct: 189 VNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQ---GRLYRQPKFLRTM 245
Query: 249 EMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRR 308
++FD+E G W K+ RS ++ +RADFV GSL G ++ GGLGNQP L + E+F + +
Sbjct: 246 DVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFHPGKNK 305
Query: 309 WEALPAMPTARCSCSSLQAGPRLFVIGGVAQGPSQAVEALCLRD 352
WE LPAMPT RC+CSS+ L +GGV QG S AVEALC+ D
Sbjct: 306 WEILPAMPTPRCACSSIVVKNCLLAVGGVNQGLSDAVEALCVSD 349
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 100 bits (250), Expect = 2e-21
Identities = 79/328 (24%), Positives = 137/328 (41%), Gaps = 29/328 (8%)
Query: 28 HQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGV 87
H G L +GG G +G P + E + ++W + + R + + +V VGG
Sbjct: 315 HTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGH 374
Query: 88 DEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRV 147
D + + ++E F +W +A++ G+A G +YA+GG+ +T V
Sbjct: 375 DGNEH-LGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFN-DVER 432
Query: 148 YEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPS 207
Y+ D W ++ M TP G + N +Y +GG G +++ E +D W
Sbjct: 433 YDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKE 492
Query: 208 LPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRM 267
+ RRA G + G ++ +GG P +++VE +D W + +
Sbjct: 493 MGQRRAGNGVSKLHGCLYVVGGFDDNSP---------LSSVERYDPRSNKWDYV---AAL 540
Query: 268 RDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTAR-------C 320
R + ++ G I A+GG N L +VE+F RWE + ++ R C
Sbjct: 541 TTPRGGVGIATVMGKIFAVGG-HNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVC 599
Query: 321 SCSSLQAGPRLFVIGGVAQGPSQAVEAL 348
SC + Q I V G + V+ +
Sbjct: 600 SCLTSQ-------IRDVGHGSNNVVDCM 620
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 97.8 bits (242), Expect = 1e-20
Identities = 79/275 (28%), Positives = 114/275 (41%), Gaps = 20/275 (7%)
Query: 64 PLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATV 123
P AR GA V+L VVGG QSP+ VE + W ++ + VA+V
Sbjct: 271 PRTRARLGANEVLL-----VVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASV 325
Query: 124 ERDGMVYALGGM-GPDTAPQAQVRVYEPRRD-CWLSLPSMPTPCYGASTFLHGNKIYVLG 181
+Y +GG G + Y D W S+ M A G+ IYV G
Sbjct: 326 SLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSG 385
Query: 182 GRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSR 241
G G T+ E +D W+ + + R AG +A G ++ LGG Y
Sbjct: 386 GFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGG---------YDG 436
Query: 242 PHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVES 301
+ +N+VE +D G WT + M KR+ V L HI +GG L SVE+
Sbjct: 437 LNILNSVEKYDPHTGHWTNVTP---MATKRSGAGVALLNDHIYVVGGFDGT-AHLSSVEA 492
Query: 302 FSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGG 336
+++ W + +M T RC + RL+ I G
Sbjct: 493 YNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAG 527
Score = 95.5 bits (236), Expect = 6e-20
Identities = 84/292 (28%), Positives = 127/292 (43%), Gaps = 20/292 (6%)
Query: 33 LLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQS 92
LLV+GG G P+D E D + W L + R A+V L ++ V+GG D +S
Sbjct: 283 LLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDG-RS 341
Query: 93 PVAAVEA--FLMDE-GRWERRATL-PQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVY 148
+++VE + DE G W A + + + AT D M+Y GG + R Y
Sbjct: 342 RLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGD-MIYVSGGFDGSRRHTSMER-Y 399
Query: 149 EPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSL 208
+P D W L M T GA + IY LGG G + + E +D WT +
Sbjct: 400 DPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPM 459
Query: 209 PSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMR 268
++R+ AG A+ ++ +GG F H +++VE +++ SWT + M
Sbjct: 460 ATKRSGAGVALLNDHIYVVGG--------FDGTAH-LSSVEAYNIRTDSWTTV---TSMT 507
Query: 269 DKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTARC 320
R L G + AI G L S+E + WE + +M T RC
Sbjct: 508 TPRCYVGATVLRGRLYAIAGYDGNSL-LSSIECYDPIIDSWEVVTSMGTQRC 558
Score = 87.8 bits (216), Expect = 1e-17
Identities = 64/252 (25%), Positives = 109/252 (43%), Gaps = 17/252 (6%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGC-GRAGLPLDTAETLDMASH---TWLALAPLP 66
W P + R Y + V+GG GR+ L + E LD + W ++AP+
Sbjct: 309 WSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRL--SSVECLDYTADEDGVWYSVAPMN 366
Query: 67 TARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERD 126
R A A LG + V GG D + + +E + + +W + A G V
Sbjct: 367 VRRGLAGATTLGDMIYVSGGFDGSRRHTS-MERYDPNIDQWSMLGDMQTAREGAGLVVAS 425
Query: 127 GMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGK 186
G++Y LGG + V Y+P W ++ M T GA L + IYV+GG G
Sbjct: 426 GVIYCLGGYDGLNILNS-VEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGT 484
Query: 187 LPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVN 246
+++ EA+++ +WT S+ + R + G + G ++++ G Y ++
Sbjct: 485 AHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAG---------YDGNSLLS 535
Query: 247 TVEMFDLEHGSW 258
++E +D SW
Sbjct: 536 SIECYDPIIDSW 547
Score = 70.5 bits (171), Expect = 2e-12
Identities = 50/174 (28%), Positives = 77/174 (44%), Gaps = 5/174 (2%)
Query: 50 ETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWER 109
E D W L + TAR GA VV + +GG D + + +VE + G W
Sbjct: 397 ERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNI-LNSVEKYDPHTGHWTN 455
Query: 110 RATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTP-CYGA 168
+ G + +Y +GG TA + V Y R D W ++ SM TP CY
Sbjct: 456 VTPMATKRSGAGVALLNDHIYVVGGFD-GTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVG 514
Query: 169 STFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAG-CAMAE 221
+T L G ++Y + G G +++ E +D +W S+ ++R AG C + E
Sbjct: 515 ATVLRG-RLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLRE 567
Score = 41.2 bits (95), Expect = 0.001
Identities = 21/68 (30%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 283 IVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQGPS 342
++ +GG G+Q P+ VE + + W LP++ R +S+ R++VIGG G S
Sbjct: 283 LLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGY-DGRS 341
Query: 343 QAVEALCL 350
+ CL
Sbjct: 342 RLSSVECL 349
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 94.7 bits (234), Expect = 1e-19
Identities = 71/285 (24%), Positives = 118/285 (41%), Gaps = 15/285 (5%)
Query: 31 GHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEV 90
G + +GG AG L+ E D ++ W P+ TAR+ V+ + +GG D
Sbjct: 288 GLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDG- 346
Query: 91 QSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEP 150
Q ++ VEA+ + W R ++ + TV DG +Y GG +++ + V Y P
Sbjct: 347 QLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSS-LSSVETYSP 405
Query: 151 RRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPS 210
D W + SM + A + +IYV GG G ++ E ++ TW + +
Sbjct: 406 ETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLN 465
Query: 211 RRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDK 270
+R G A +F GG Y F++ EM+ W + + M +
Sbjct: 466 KRCRHGAASLGSKMFVCGG---------YDGSGFLSIAEMYSSVADQWCLI---VPMHTR 513
Query: 271 RADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAM 315
R+ + + G + A+GG Q L SVE + W + M
Sbjct: 514 RSRVSLVASCGRLYAVGGYDGQ-SNLSSVEMYDPETDCWTFMAPM 557
Score = 85.5 bits (210), Expect = 7e-17
Identities = 66/256 (25%), Positives = 105/256 (41%), Gaps = 14/256 (5%)
Query: 81 VLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTA 140
+ VGG++ + VE F WER + A V +G++YA+GG
Sbjct: 290 IYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLR 349
Query: 141 PQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEAR 200
+ V Y P D W + SM + T + +IYV GG G +++ E + E
Sbjct: 350 -LSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETD 408
Query: 201 TWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTK 260
WT S+ S R+ AG + EG ++ GG + ++VE ++ +W
Sbjct: 409 KWTVVTSMSSNRSAAGVTVFEGRIYVSGG---------HDGLQIFSSVEHYNHHTATWHP 459
Query: 261 LPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTARC 320
+ M +KR SLG + GG L E +S +W + M T R
Sbjct: 460 ---AAGMLNKRCRHGAASLGSKMFVCGGYDGSGF-LSIAEMYSSVADQWCLIVPMHTRRS 515
Query: 321 SCSSLQAGPRLFVIGG 336
S + + RL+ +GG
Sbjct: 516 RVSLVASCGRLYAVGG 531
Score = 82.4 bits (202), Expect = 6e-16
Identities = 59/225 (26%), Positives = 94/225 (41%), Gaps = 18/225 (8%)
Query: 112 TLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTF 171
T P+ +A G++YA+GG+ V V++P +CW M T
Sbjct: 278 TRPRCCTSIA-----GLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVA 332
Query: 172 LHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQ 231
+ +Y +GG G+L ++ EA++ E TWTR S+ S+R+ G + +G ++ GG
Sbjct: 333 VVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGG-- 390
Query: 232 QPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGN 291
Y +++VE + E WT + M R+ V G I GG
Sbjct: 391 -------YDGNSSLSSVETYSPETDKWTVV---TSMSSNRSAAGVTVFEGRIYVSGGHDG 440
Query: 292 QPCPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGG 336
SVE ++ W M RC + G ++FV GG
Sbjct: 441 LQI-FSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGG 484
Score = 70.1 bits (170), Expect = 3e-12
Identities = 64/254 (25%), Positives = 106/254 (41%), Gaps = 16/254 (6%)
Query: 8 AFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPT 67
A W+ PM T R VA +G L +GG L L T E + + TW + + +
Sbjct: 313 ANCWERCRPMTTARSRVGVAVVNGLLYAIGGYD-GQLRLSTVEAYNPETDTWTRVGSMNS 371
Query: 68 ARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDG 127
R+ VVL Q+ V GG D S +++VE + + +W ++ +G
Sbjct: 372 KRSAMGTVVLDGQIYVCGGYDG-NSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEG 430
Query: 128 MVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTP-C-YGASTFLHGNKIYVLGGRQG 185
+Y GG + V Y W M C +GA++ G+K++V GG G
Sbjct: 431 RIYVSGG-HDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASL--GSKMFVCGGYDG 487
Query: 186 KLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFV 245
++ E + A W + +RR+ + G ++++GG Y +
Sbjct: 488 SGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGG---------YDGQSNL 538
Query: 246 NTVEMFDLEHGSWT 259
++VEM+D E WT
Sbjct: 539 SSVEMYDPETDCWT 552
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 89.7 bits (221), Expect = 3e-18
Identities = 70/262 (26%), Positives = 117/262 (44%), Gaps = 14/262 (5%)
Query: 75 VVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGG 134
V L K ++VVGG + + +VE + +E RW++ A LP V G VYA+GG
Sbjct: 297 VSLPKVMIVVGG--QAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGG 354
Query: 135 MGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEA 194
+ V VY+ +D W S+ SM + + +Y +GG G + + EA
Sbjct: 355 FNGSLRVRT-VDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEA 413
Query: 195 FDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLE 254
+ + W + +RR+ G + EG ++++GG ++ SR ++TVE ++
Sbjct: 414 YSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGG------YDGASR-QCLSTVEQYNPA 466
Query: 255 HGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPA 314
W + M +R+ VG L G + A GG + P SVE + W+ +
Sbjct: 467 TNEWIYV---ADMSTRRSGAGVGVLSGQLYATGG-HDGPLVRKSVEVYDPGTNTWKQVAD 522
Query: 315 MPTARCSCSSLQAGPRLFVIGG 336
M R + L+V+GG
Sbjct: 523 MNMCRRNAGVCAVNGLLYVVGG 544
Score = 85.5 bits (210), Expect = 7e-17
Identities = 69/258 (26%), Positives = 109/258 (42%), Gaps = 16/258 (6%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W +P+ R V GH+ +GG L + T + D W ++A + R+
Sbjct: 327 WDQIAELPSRRCRAGVVFMAGHVYAVGGFN-GSLRVRTVDVYDGVKDQWTSIASMQERRS 385
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLP--QAAMGVATVERDGM 128
A VL + VGG D + +A+VEA+ W A + ++++GV VE G
Sbjct: 386 TLGAAVLNDLLYAVGGFDG-STGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVE--GK 442
Query: 129 VYALGGM-GPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKL 187
+YA+GG G + V Y P + W+ + M T GA + ++Y GG G L
Sbjct: 443 LYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL 502
Query: 188 PVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNT 247
+ E +D TW + + R AG G ++ +GG G N S
Sbjct: 503 VRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGG--DDGSCNLAS------- 553
Query: 248 VEMFDLEHGSWTKLPRSL 265
VE ++ WT LP ++
Sbjct: 554 VEYYNPVTDKWTLLPTNM 571
Score = 76.6 bits (187), Expect = 3e-14
Identities = 68/290 (23%), Positives = 124/290 (42%), Gaps = 20/290 (6%)
Query: 33 LLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQS 92
++V+GG +A + + E D W +A LP+ R A V + V VGG +
Sbjct: 303 MIVVGG--QAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNG-SL 359
Query: 93 PVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRR 152
V V+ + + +W A++ + + + ++YA+GG T A V Y +
Sbjct: 360 RVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTG-LASVEAYSYKT 418
Query: 153 DCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQG--KLPVTAFEAFDLEARTWTRHPSLPS 210
+ W + M T + K+Y +GG G + ++ E ++ W + +
Sbjct: 419 NEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMST 478
Query: 211 RRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDK 270
RR+ AG + G +++ GG + P +VE++D +W ++ M
Sbjct: 479 RRSGAGVGVLSGQLYATGG---------HDGPLVRKSVEVYDPGTNTWKQV---ADMNMC 526
Query: 271 RADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPA-MPTAR 319
R + V ++ G + +GG + C L SVE ++ +W LP M T R
Sbjct: 527 RRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPVTDKWTLLPTNMSTGR 575
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 88.6 bits (218), Expect = 8e-18
Identities = 71/275 (25%), Positives = 126/275 (45%), Gaps = 21/275 (7%)
Query: 50 ETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWER 109
E D + W +A + T RA +G ++ VGG D S +A VE++ W+
Sbjct: 360 EAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGT-SDLATVESYDPVTNTWQP 418
Query: 110 RATLP--QAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPC-Y 166
++ ++ +GVA + G++Y+ GG + + R Y+P W S+ +M T Y
Sbjct: 419 EVSMGTRRSCLGVAALH--GLLYSAGGYDGASCLNSAER-YDPLTGTWTSVAAMSTRRRY 475
Query: 167 GASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFS 226
L GN +Y +GG + E ++ + W+ S+ SRR+ AG A+ EG+++
Sbjct: 476 VRVATLDGN-LYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYV 534
Query: 227 LGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAI 286
GG +N+VE + + G+W + M +R+ + ++ G + A+
Sbjct: 535 AGGNDGTS---------CLNSVERYSPKAGAWESVAP---MNIRRSTHDLVAMDGWLYAV 582
Query: 287 GGLGNQPCPLGSVESFSLARRRWEALPAMPTARCS 321
GG + L S+E ++ +W A M T R S
Sbjct: 583 GG-NDGSSSLNSIEKYNPRTNKWVAASCMFTRRSS 616
Score = 77.8 bits (190), Expect = 1e-14
Identities = 57/209 (27%), Positives = 91/209 (43%), Gaps = 14/209 (6%)
Query: 128 MVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKL 187
+++A+GG G A Y+ R D W + SM T GN++Y +GG G
Sbjct: 343 VLFAVGG-GSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTS 401
Query: 188 PVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNT 247
+ E++D TW S+ +RR+ G A G ++S GG Y +N+
Sbjct: 402 DLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGG---------YDGASCLNS 452
Query: 248 VEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARR 307
E +D G+WT + M +R V +L G++ A+GG + L +VE +
Sbjct: 453 AERYDPLTGTWTSV---AAMSTRRRYVRVATLDGNLYAVGGY-DSSSHLATVEKYEPQVN 508
Query: 308 RWEALPAMPTARCSCSSLQAGPRLFVIGG 336
W + +M + R S L+V GG
Sbjct: 509 VWSPVASMLSRRSSAGVAVLEGALYVAGG 537
Score = 75.5 bits (184), Expect = 7e-14
Identities = 68/243 (27%), Positives = 109/243 (44%), Gaps = 22/243 (9%)
Query: 98 EAFLMDEGRWERRATLP--QAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCW 155
EA+ RW A++ +A +GVA V +YA+GG T+ A V Y+P + W
Sbjct: 360 EAYDTRTDRWHVVASMSTRRARVGVAAV--GNRLYAVGGYD-GTSDLATVESYDPVTNTW 416
Query: 156 LSLPSMPT--PCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRA 213
SM T C G + LHG +Y GG G + + E +D TWT ++ +RR
Sbjct: 417 QPEVSMGTRRSCLGVAA-LHG-LLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRR 474
Query: 214 FAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRAD 273
+ A +G+++++GG Y + TVE ++ + W+ + L +R+
Sbjct: 475 YVRVATLDGNLYAVGG---------YDSSSHLATVEKYEPQVNVWSPVASML---SRRSS 522
Query: 274 FVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFV 333
V L G + GG C L SVE +S WE++ M R + + L+
Sbjct: 523 AGVAVLEGALYVAGGNDGTSC-LNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYA 581
Query: 334 IGG 336
+GG
Sbjct: 582 VGG 584
Score = 67.4 bits (163), Expect = 2e-11
Identities = 61/242 (25%), Positives = 94/242 (38%), Gaps = 17/242 (7%)
Query: 2 SAGGGRAFA--------------WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLD 47
+ GGG FA W V M T R VA L +GG L
Sbjct: 346 AVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTS-DLA 404
Query: 48 TAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRW 107
T E+ D ++TW + T R+ L + GG D S + + E + G W
Sbjct: 405 TVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGA-SCLNSAERYDPLTGTW 463
Query: 108 ERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYG 167
A + V DG +YA+GG ++ A V YEP+ + W + SM +
Sbjct: 464 TSVAAMSTRRRYVRVATLDGNLYAVGGYD-SSSHLATVEKYEPQVNVWSPVASMLSRRSS 522
Query: 168 ASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSL 227
A + +YV GG G + + E + +A W + RR+ +G ++++
Sbjct: 523 AGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAV 582
Query: 228 GG 229
GG
Sbjct: 583 GG 584
Score = 63.5 bits (153), Expect = 3e-10
Identities = 58/213 (27%), Positives = 87/213 (40%), Gaps = 7/213 (3%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
WQ M T R VA G L GG A L++AE D + TW ++A + T R
Sbjct: 416 WQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASC-LNSAERYDPLTGTWTSVAAMSTRRR 474
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATL--PQAAMGVATVERDGM 128
L + VGG D S +A VE + W A++ +++ GVA +E G
Sbjct: 475 YVRVATLDGNLYAVGGYDS-SSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLE--GA 531
Query: 129 VYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLP 188
+Y GG T+ V Y P+ W S+ M +Y +GG G
Sbjct: 532 LYVAGG-NDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSS 590
Query: 189 VTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAE 221
+ + E ++ W + +RR+ G A+ E
Sbjct: 591 LNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLE 623
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 86.7 bits (213), Expect = 3e-17
Identities = 66/260 (25%), Positives = 117/260 (45%), Gaps = 14/260 (5%)
Query: 77 LGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMG 136
L K ++VVGG + + +VE + E RW + A LP V G+V+A+GG
Sbjct: 217 LPKLMVVVGG--QAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFN 274
Query: 137 PDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFD 196
+ V Y+P +D W S+ +M + +Y +GG G +++ EA++
Sbjct: 275 GSLRVRT-VDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYN 333
Query: 197 LEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHG 256
+++ W + +RR+ G + G ++++GG ++ SR ++TVE ++
Sbjct: 334 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGG------YDGASR-QCLSTVECYNATTN 386
Query: 257 SWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMP 316
WT + M +R+ VG L + A+GG + P SVE + W + M
Sbjct: 387 EWTYI---AEMSTRRSGAGVGVLNNLLYAVGG-HDGPLVRKSVEVYDPTTNAWRQVADMN 442
Query: 317 TARCSCSSLQAGPRLFVIGG 336
R + L+V+GG
Sbjct: 443 MCRRNAGVCAVNGLLYVVGG 462
Score = 75.9 bits (185), Expect = 5e-14
Identities = 67/290 (23%), Positives = 125/290 (43%), Gaps = 19/290 (6%)
Query: 33 LLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQS 92
L+V+ G G+A + + E D W +A LP+ R A V + V VGG +
Sbjct: 220 LMVVVG-GQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNG-SL 277
Query: 93 PVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRR 152
V V+++ + +W A + + +G++YA+GG T + V Y +
Sbjct: 278 RVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTG-LSSVEAYNIKS 336
Query: 153 DCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQG--KLPVTAFEAFDLEARTWTRHPSLPS 210
+ W + M T + G +Y +GG G + ++ E ++ WT + +
Sbjct: 337 NEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMST 396
Query: 211 RRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDK 270
RR+ AG + ++++GG + P +VE++D +W ++ M
Sbjct: 397 RRSGAGVGVLNNLLYAVGG---------HDGPLVRKSVEVYDPTTNAWRQV---ADMNMC 444
Query: 271 RADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPA-MPTAR 319
R + V ++ G + +GG + C L SVE ++ +W + + M T R
Sbjct: 445 RRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPTTDKWTVVSSCMSTGR 493
Score = 73.6 bits (179), Expect = 3e-13
Identities = 53/220 (24%), Positives = 90/220 (40%), Gaps = 3/220 (1%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W +P+ R + + G + +GG L + T ++ D W ++A + R+
Sbjct: 245 WHQVAELPSRRCRAGMVYMAGLVFAVGGFN-GSLRVRTVDSYDPVKDQWTSVANMRDRRS 303
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVY 130
A VL + VGG D + +++VEA+ + W A + V G++Y
Sbjct: 304 TLGAAVLNGLLYAVGGFDG-STGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 362
Query: 131 ALGGM-GPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPV 189
A+GG G + V Y + W + M T GA + N +Y +GG G L
Sbjct: 363 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVR 422
Query: 190 TAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGG 229
+ E +D W + + R AG G ++ +GG
Sbjct: 423 KSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG 462
Score = 63.2 bits (152), Expect = 3e-10
Identities = 50/196 (25%), Positives = 85/196 (43%), Gaps = 8/196 (4%)
Query: 30 DGHLLVLGGC-GRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVD 88
+G L +GG G GL + E ++ S+ W +AP+ T R+ V+G + VGG D
Sbjct: 311 NGLLYAVGGFDGSTGL--SSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYD 368
Query: 89 EVQSP-VAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGM-GPDTAPQAQVR 146
++ VE + W A + G + ++YA+GG GP + V
Sbjct: 369 GASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGP--LVRKSVE 426
Query: 147 VYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHP 206
VY+P + W + M A +YV+GG G + + E ++ WT
Sbjct: 427 VYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVS 486
Query: 207 S-LPSRRAFAGCAMAE 221
S + + R++AG + +
Sbjct: 487 SCMSTGRSYAGVTVID 502
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 86.7 bits (213), Expect = 3e-17
Identities = 66/260 (25%), Positives = 117/260 (45%), Gaps = 14/260 (5%)
Query: 77 LGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMG 136
L K ++VVGG + + +VE + E RW + A LP V G+V+A+GG
Sbjct: 309 LPKLMVVVGG--QAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFN 366
Query: 137 PDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFD 196
+ V Y+P +D W S+ +M + +Y +GG G +++ EA++
Sbjct: 367 GSLRVRT-VDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYN 425
Query: 197 LEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHG 256
+++ W + +RR+ G + G ++++GG ++ SR ++TVE ++
Sbjct: 426 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGG------YDGASR-QCLSTVECYNATTN 478
Query: 257 SWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMP 316
WT + M +R+ VG L + A+GG + P SVE + W + M
Sbjct: 479 EWTYI---AEMSTRRSGAGVGVLNNLLYAVGG-HDGPLVRKSVEVYDPTTNAWRQVADMN 534
Query: 317 TARCSCSSLQAGPRLFVIGG 336
R + L+V+GG
Sbjct: 535 MCRRNAGVCAVNGLLYVVGG 554
Score = 75.9 bits (185), Expect = 5e-14
Identities = 67/290 (23%), Positives = 125/290 (43%), Gaps = 19/290 (6%)
Query: 33 LLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQS 92
L+V+ G G+A + + E D W +A LP+ R A V + V VGG +
Sbjct: 312 LMVVVG-GQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNG-SL 369
Query: 93 PVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRR 152
V V+++ + +W A + + +G++YA+GG T + V Y +
Sbjct: 370 RVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTG-LSSVEAYNIKS 428
Query: 153 DCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQG--KLPVTAFEAFDLEARTWTRHPSLPS 210
+ W + M T + G +Y +GG G + ++ E ++ WT + +
Sbjct: 429 NEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMST 488
Query: 211 RRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDK 270
RR+ AG + ++++GG + P +VE++D +W ++ M
Sbjct: 489 RRSGAGVGVLNNLLYAVGG---------HDGPLVRKSVEVYDPTTNAWRQV---ADMNMC 536
Query: 271 RADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPA-MPTAR 319
R + V ++ G + +GG + C L SVE ++ +W + + M T R
Sbjct: 537 RRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPTTDKWTVVSSCMSTGR 585
Score = 73.6 bits (179), Expect = 3e-13
Identities = 53/220 (24%), Positives = 90/220 (40%), Gaps = 3/220 (1%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W +P+ R + + G + +GG L + T ++ D W ++A + R+
Sbjct: 337 WHQVAELPSRRCRAGMVYMAGLVFAVGGFN-GSLRVRTVDSYDPVKDQWTSVANMRDRRS 395
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVY 130
A VL + VGG D + +++VEA+ + W A + V G++Y
Sbjct: 396 TLGAAVLNGLLYAVGGFDG-STGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 454
Query: 131 ALGGM-GPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPV 189
A+GG G + V Y + W + M T GA + N +Y +GG G L
Sbjct: 455 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVR 514
Query: 190 TAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGG 229
+ E +D W + + R AG G ++ +GG
Sbjct: 515 KSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG 554
Score = 63.2 bits (152), Expect = 3e-10
Identities = 50/196 (25%), Positives = 85/196 (43%), Gaps = 8/196 (4%)
Query: 30 DGHLLVLGGC-GRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVD 88
+G L +GG G GL + E ++ S+ W +AP+ T R+ V+G + VGG D
Sbjct: 403 NGLLYAVGGFDGSTGL--SSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYD 460
Query: 89 EVQSP-VAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGM-GPDTAPQAQVR 146
++ VE + W A + G + ++YA+GG GP + V
Sbjct: 461 GASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGP--LVRKSVE 518
Query: 147 VYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHP 206
VY+P + W + M A +YV+GG G + + E ++ WT
Sbjct: 519 VYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVS 578
Query: 207 S-LPSRRAFAGCAMAE 221
S + + R++AG + +
Sbjct: 579 SCMSTGRSYAGVTVID 594
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 86.7 bits (213), Expect = 3e-17
Identities = 66/260 (25%), Positives = 117/260 (45%), Gaps = 14/260 (5%)
Query: 77 LGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMG 136
L K ++VVGG + + +VE + E RW + A LP V G+V+A+GG
Sbjct: 305 LPKLMVVVGG--QAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFN 362
Query: 137 PDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFD 196
+ V Y+P +D W S+ +M + +Y +GG G +++ EA++
Sbjct: 363 GSLRVRT-VDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYN 421
Query: 197 LEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHG 256
+++ W + +RR+ G + G ++++GG ++ SR ++TVE ++
Sbjct: 422 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGG------YDGASR-QCLSTVECYNATTN 474
Query: 257 SWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMP 316
WT + M +R+ VG L + A+GG + P SVE + W + M
Sbjct: 475 EWTYI---AEMSTRRSGAGVGVLNNLLYAVGG-HDGPLVRKSVEVYDPTTNAWRQVADMN 530
Query: 317 TARCSCSSLQAGPRLFVIGG 336
R + L+V+GG
Sbjct: 531 MCRRNAGVCAVNGLLYVVGG 550
Score = 75.9 bits (185), Expect = 5e-14
Identities = 67/290 (23%), Positives = 125/290 (43%), Gaps = 19/290 (6%)
Query: 33 LLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQS 92
L+V+ G G+A + + E D W +A LP+ R A V + V VGG +
Sbjct: 308 LMVVVG-GQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNG-SL 365
Query: 93 PVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRR 152
V V+++ + +W A + + +G++YA+GG T + V Y +
Sbjct: 366 RVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTG-LSSVEAYNIKS 424
Query: 153 DCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQG--KLPVTAFEAFDLEARTWTRHPSLPS 210
+ W + M T + G +Y +GG G + ++ E ++ WT + +
Sbjct: 425 NEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMST 484
Query: 211 RRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDK 270
RR+ AG + ++++GG + P +VE++D +W ++ M
Sbjct: 485 RRSGAGVGVLNNLLYAVGG---------HDGPLVRKSVEVYDPTTNAWRQV---ADMNMC 532
Query: 271 RADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPA-MPTAR 319
R + V ++ G + +GG + C L SVE ++ +W + + M T R
Sbjct: 533 RRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPTTDKWTVVSSCMSTGR 581
Score = 73.6 bits (179), Expect = 3e-13
Identities = 53/220 (24%), Positives = 90/220 (40%), Gaps = 3/220 (1%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W +P+ R + + G + +GG L + T ++ D W ++A + R+
Sbjct: 333 WHQVAELPSRRCRAGMVYMAGLVFAVGGFN-GSLRVRTVDSYDPVKDQWTSVANMRDRRS 391
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVY 130
A VL + VGG D + +++VEA+ + W A + V G++Y
Sbjct: 392 TLGAAVLNGLLYAVGGFDG-STGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 450
Query: 131 ALGGM-GPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPV 189
A+GG G + V Y + W + M T GA + N +Y +GG G L
Sbjct: 451 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVR 510
Query: 190 TAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGG 229
+ E +D W + + R AG G ++ +GG
Sbjct: 511 KSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG 550
Score = 63.2 bits (152), Expect = 3e-10
Identities = 50/196 (25%), Positives = 85/196 (43%), Gaps = 8/196 (4%)
Query: 30 DGHLLVLGGC-GRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVD 88
+G L +GG G GL + E ++ S+ W +AP+ T R+ V+G + VGG D
Sbjct: 399 NGLLYAVGGFDGSTGL--SSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYD 456
Query: 89 EVQSP-VAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGM-GPDTAPQAQVR 146
++ VE + W A + G + ++YA+GG GP + V
Sbjct: 457 GASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGP--LVRKSVE 514
Query: 147 VYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHP 206
VY+P + W + M A +YV+GG G + + E ++ WT
Sbjct: 515 VYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVS 574
Query: 207 S-LPSRRAFAGCAMAE 221
S + + R++AG + +
Sbjct: 575 SCMSTGRSYAGVTVID 590
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 86.3 bits (212), Expect = 4e-17
Identities = 69/265 (26%), Positives = 107/265 (40%), Gaps = 19/265 (7%)
Query: 79 KQVLVVGGVDEVQS-------PVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYA 131
K + VGG +Q ++ VE F W ++L QA G+ GMVYA
Sbjct: 288 KYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYA 347
Query: 132 LGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTA 191
+GG D+ Y+P W ++ SM P G + IY LGG G
Sbjct: 348 IGG-EKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNT 406
Query: 192 FEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMF 251
E FD + W ++ R + GC +G ++ +GG+ G + + E++
Sbjct: 407 IERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIE--------LRSFEVY 458
Query: 252 DLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEA 311
D W+ LP M +RA V +L I ++GG L +VE +S +W
Sbjct: 459 DPLSKRWSPLP---PMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVE 515
Query: 312 LPAMPTARCSCSSLQAGPRLFVIGG 336
+ +M R + L+V GG
Sbjct: 516 VASMKVPRAGMCVVAVNGLLYVSGG 540
Score = 86.3 bits (212), Expect = 4e-17
Identities = 73/297 (24%), Positives = 125/297 (42%), Gaps = 21/297 (7%)
Query: 31 GHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEV 90
G+ + GG L E D S W ++ L AR+G VLG V +GG ++
Sbjct: 295 GYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGG-EKD 353
Query: 91 QSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGG-MGPDTAPQAQVRVYE 149
E + +W A++ G+ G +YALGG +G + + ++
Sbjct: 354 SMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIG--NTIERFD 411
Query: 150 PRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGK-LPVTAFEAFDLEARTWTRHPSL 208
P + W + +M Y IYV+GG + + + +FE +D ++ W+ P +
Sbjct: 412 PDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPM 471
Query: 209 PSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMR 268
+RRA+ G A ++S+GG + ++TVE + E W ++ M+
Sbjct: 472 GTRRAYLGVAALNDCIYSVGGWNE--------TQDALHTVEKYSFEEEKWVEV---ASMK 520
Query: 269 DKRADFVVGSLGGHIVAIGGLGNQ-----PCPLGSVESFSLARRRWEALPAMPTARC 320
RA V ++ G + GG + P L SVE ++ W + M T+RC
Sbjct: 521 VPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRC 577
Score = 77.0 bits (188), Expect = 2e-14
Identities = 50/170 (29%), Positives = 71/170 (41%), Gaps = 10/170 (5%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W+V M R Y G + V+GG G+ L + E D S W L P+ T RA
Sbjct: 417 WEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRA 476
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVY 130
L + VGG +E Q + VE + +E +W A++ G+ V +G++Y
Sbjct: 477 YLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLY 536
Query: 131 ALGG-------MGPDTAPQAQVRVYEPRRDCWLSLPSMPTP-CYGASTFL 172
GG + P T V VY P D W + +M T C G L
Sbjct: 537 VSGGRSSSHDFLAPGTLD--SVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
Score = 41.2 bits (95), Expect = 0.001
Identities = 40/164 (24%), Positives = 65/164 (39%), Gaps = 24/164 (14%)
Query: 181 GGR-QGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFY 239
GGR ++ E FD ++ WT SL R+ G + G V+++GG +
Sbjct: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDS------ 354
Query: 240 SRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGG-----LGNQPC 294
+ E +D WT + M R V G I A+GG +GN
Sbjct: 355 ---MIFDCTECYDPVTKQWTTVAS---MNHPRCGLGVCVCYGAIYALGGWVGAEIGN--- 405
Query: 295 PLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVA 338
++E F +WE + M +R + ++VIGG++
Sbjct: 406 ---TIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGIS 446
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 86.3 bits (212), Expect = 4e-17
Identities = 69/265 (26%), Positives = 107/265 (40%), Gaps = 19/265 (7%)
Query: 79 KQVLVVGGVDEVQS-------PVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYA 131
K + VGG +Q ++ VE F W ++L QA G+ GMVYA
Sbjct: 288 KYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYA 347
Query: 132 LGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTA 191
+GG D+ Y+P W ++ SM P G + IY LGG G
Sbjct: 348 IGG-EKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNT 406
Query: 192 FEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMF 251
E FD + W ++ R + GC +G ++ +GG+ G + + E++
Sbjct: 407 IERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIE--------LRSFEVY 458
Query: 252 DLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEA 311
D W+ LP M +RA V +L I ++GG L +VE +S +W
Sbjct: 459 DPLSKRWSPLP---PMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVE 515
Query: 312 LPAMPTARCSCSSLQAGPRLFVIGG 336
+ +M R + L+V GG
Sbjct: 516 VASMKVPRAGMCVVAVNGLLYVSGG 540
Score = 78.6 bits (192), Expect = 8e-15
Identities = 67/283 (23%), Positives = 118/283 (41%), Gaps = 17/283 (6%)
Query: 31 GHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEV 90
G+ + GG L E D S W ++ L AR+G VLG V +GG ++
Sbjct: 295 GYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGG-EKD 353
Query: 91 QSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGG-MGPDTAPQAQVRVYE 149
E + +W A++ G+ G +YALGG +G + + ++
Sbjct: 354 SMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIG--NTIERFD 411
Query: 150 PRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGK-LPVTAFEAFDLEARTWTRHPSL 208
P + W + +M Y IYV+GG + + + +FE +D ++ W+ P +
Sbjct: 412 PDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPM 471
Query: 209 PSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMR 268
+RRA+ G A ++S+GG + ++TVE + E W ++ M+
Sbjct: 472 GTRRAYLGVAALNDCIYSVGGWNE--------TQDALHTVEKYSFEEEKWVEV---ASMK 520
Query: 269 DKRADFVVGSLGGHIVAIGGLGNQPCPLG-SVESFSLARRRWE 310
RA V ++ G + GG + L + + R +WE
Sbjct: 521 VPRAGMCVVAVNGLLYVSGGRSSSHDFLAPDTHRYEVFRLKWE 563
Score = 68.2 bits (165), Expect = 1e-11
Identities = 40/136 (29%), Positives = 59/136 (43%), Gaps = 7/136 (5%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W+V M R Y G + V+GG G+ L + E D S W L P+ T RA
Sbjct: 417 WEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRA 476
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVY 130
L + VGG +E Q + VE + +E +W A++ G+ V +G++Y
Sbjct: 477 YLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLY 536
Query: 131 ALGG-------MGPDT 139
GG + PDT
Sbjct: 537 VSGGRSSSHDFLAPDT 552
Score = 41.2 bits (95), Expect = 0.001
Identities = 40/164 (24%), Positives = 65/164 (39%), Gaps = 24/164 (14%)
Query: 181 GGR-QGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFY 239
GGR ++ E FD ++ WT SL R+ G + G V+++GG +
Sbjct: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDS------ 354
Query: 240 SRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGG-----LGNQPC 294
+ E +D WT + M R V G I A+GG +GN
Sbjct: 355 ---MIFDCTECYDPVTKQWTTVAS---MNHPRCGLGVCVCYGAIYALGGWVGAEIGN--- 405
Query: 295 PLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVA 338
++E F +WE + M +R + ++VIGG++
Sbjct: 406 ---TIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGIS 446
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 85.9 bits (211), Expect = 5e-17
Identities = 62/210 (29%), Positives = 94/210 (44%), Gaps = 7/210 (3%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W V PPM T R VA +G + +GG L+T E D + W +A + T R+
Sbjct: 495 WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSY-LNTVERWDPQARQWNFVATMSTPRS 553
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVY 130
VL ++ VGG D S + +VE F +W A + + GV +G++Y
Sbjct: 554 TVGVAVLSGKLYAVGGRDG-SSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLY 612
Query: 131 ALGGMGPDTAPQAQ-----VRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQG 185
A+GG + V Y+P+ D W ++ SM L G+K+Y +GG G
Sbjct: 613 AIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDG 672
Query: 186 KLPVTAFEAFDLEARTWTRHPSLPSRRAFA 215
+ + EA+D + WT+ L RA A
Sbjct: 673 QAYLNTVEAYDPQTNEWTQVAPLCLGRAGA 702
Score = 79.3 bits (194), Expect = 5e-15
Identities = 66/260 (25%), Positives = 108/260 (41%), Gaps = 9/260 (3%)
Query: 50 ETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWER 109
E D+ ++ W +A + R VL ++ VVGG D +++ + VE + W
Sbjct: 439 EKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKT-LNTVECYNPKTKTWSV 497
Query: 110 RATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGAS 169
+ G+ +G +YA+GG + V ++P+ W + +M TP
Sbjct: 498 MPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERWDPQARQWNFVATMSTPRSTVG 556
Query: 170 TFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGG 229
+ K+Y +GGR G + + E FD WT + RR G G ++++GG
Sbjct: 557 VAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG 616
Query: 230 LQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGL 289
P N SR + VE +D + WT + RD V LG + A+GG
Sbjct: 617 HDAPA-SNLTSR--LSDCVERYDPKTDMWTAVASMSISRDAVG---VCLLGDKLYAVGGY 670
Query: 290 GNQPCPLGSVESFSLARRRW 309
Q L +VE++ W
Sbjct: 671 DGQ-AYLNTVEAYDPQTNEW 689
Score = 74.3 bits (181), Expect = 2e-13
Identities = 69/264 (26%), Positives = 109/264 (41%), Gaps = 24/264 (9%)
Query: 7 RAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLP-LDTAETLDMASHTWLALAPL 65
R W M R+ VA D L V+GG R GL L+T E + + TW + P+
Sbjct: 444 RTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG--RDGLKTLNTVECYNPKTKTWSVMPPM 501
Query: 66 PTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATL--PQAAMGVATV 123
T R G VL + VGG D S + VE + +W AT+ P++ +GVA +
Sbjct: 502 STHRHGLGVAVLEGPMYAVGGHDG-WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVL 560
Query: 124 ERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGR 183
G +YA+GG + ++ V ++P + W M G +Y +GG
Sbjct: 561 --SGKLYAVGGRDGSSCLKS-VECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGH 617
Query: 184 QGKLP------VTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHN 237
E +D + WT S+ R G + ++++GG
Sbjct: 618 DAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG-------- 669
Query: 238 FYSRPHFVNTVEMFDLEHGSWTKL 261
Y ++NTVE +D + WT++
Sbjct: 670 -YDGQAYLNTVEAYDPQTNEWTQV 692
Score = 73.6 bits (179), Expect = 3e-13
Identities = 60/261 (22%), Positives = 103/261 (39%), Gaps = 19/261 (7%)
Query: 81 VLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTA 140
+ VGG+D + ++E + + W A + + D +Y +GG
Sbjct: 423 LFAVGGMDSTKG-ATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-GLK 480
Query: 141 PQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEAR 200
V Y P+ W +P M T +G + +Y +GG G + E +D +AR
Sbjct: 481 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 540
Query: 201 TWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTK 260
W ++ + R+ G A+ G ++++GG + +VE FD WT
Sbjct: 541 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS---------CLKSVECFDPHTNKWT- 590
Query: 261 LPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGS-----VESFSLARRRWEALPAM 315
+M +R V + G + AIGG L S VE + W A+ +M
Sbjct: 591 --LCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASM 648
Query: 316 PTARCSCSSLQAGPRLFVIGG 336
+R + G +L+ +GG
Sbjct: 649 SISRDAVGVCLLGDKLYAVGG 669
Score = 28.9 bits (63), Expect = 7.3
Identities = 13/32 (40%), Positives = 18/32 (56%)
Query: 46 LDTAETLDMASHTWLALAPLPTARAGAAAVVL 77
L+T E D ++ W +APL RAGA V +
Sbjct: 676 LNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 707
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 85.9 bits (211), Expect = 5e-17
Identities = 62/210 (29%), Positives = 94/210 (44%), Gaps = 7/210 (3%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W V PPM T R VA +G + +GG L+T E D + W +A + T R+
Sbjct: 480 WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSY-LNTVERWDPQARQWNFVATMSTPRS 538
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVY 130
VL ++ VGG D S + +VE F +W A + + GV +G++Y
Sbjct: 539 TVGVAVLSGKLYAVGGRDG-SSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLY 597
Query: 131 ALGGMGPDTAPQAQ-----VRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQG 185
A+GG + V Y+P+ D W ++ SM L G+K+Y +GG G
Sbjct: 598 AIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDG 657
Query: 186 KLPVTAFEAFDLEARTWTRHPSLPSRRAFA 215
+ + EA+D + WT+ L RA A
Sbjct: 658 QAYLNTVEAYDPQTNEWTQVAPLCLGRAGA 687
Score = 79.3 bits (194), Expect = 5e-15
Identities = 66/260 (25%), Positives = 108/260 (41%), Gaps = 9/260 (3%)
Query: 50 ETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWER 109
E D+ ++ W +A + R VL ++ VVGG D +++ + VE + W
Sbjct: 424 EKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKT-LNTVECYNPKTKTWSV 482
Query: 110 RATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGAS 169
+ G+ +G +YA+GG + V ++P+ W + +M TP
Sbjct: 483 MPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERWDPQARQWNFVATMSTPRSTVG 541
Query: 170 TFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGG 229
+ K+Y +GGR G + + E FD WT + RR G G ++++GG
Sbjct: 542 VAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG 601
Query: 230 LQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGL 289
P N SR + VE +D + WT + RD V LG + A+GG
Sbjct: 602 HDAPA-SNLTSR--LSDCVERYDPKTDMWTAVASMSISRDAVG---VCLLGDKLYAVGGY 655
Query: 290 GNQPCPLGSVESFSLARRRW 309
Q L +VE++ W
Sbjct: 656 DGQ-AYLNTVEAYDPQTNEW 674
Score = 74.3 bits (181), Expect = 2e-13
Identities = 69/264 (26%), Positives = 109/264 (41%), Gaps = 24/264 (9%)
Query: 7 RAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLP-LDTAETLDMASHTWLALAPL 65
R W M R+ VA D L V+GG R GL L+T E + + TW + P+
Sbjct: 429 RTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG--RDGLKTLNTVECYNPKTKTWSVMPPM 486
Query: 66 PTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATL--PQAAMGVATV 123
T R G VL + VGG D S + VE + +W AT+ P++ +GVA +
Sbjct: 487 STHRHGLGVAVLEGPMYAVGGHDG-WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVL 545
Query: 124 ERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGR 183
G +YA+GG + ++ V ++P + W M G +Y +GG
Sbjct: 546 --SGKLYAVGGRDGSSCLKS-VECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGH 602
Query: 184 QGKLP------VTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHN 237
E +D + WT S+ R G + ++++GG
Sbjct: 603 DAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG-------- 654
Query: 238 FYSRPHFVNTVEMFDLEHGSWTKL 261
Y ++NTVE +D + WT++
Sbjct: 655 -YDGQAYLNTVEAYDPQTNEWTQV 677
Score = 73.6 bits (179), Expect = 3e-13
Identities = 60/261 (22%), Positives = 103/261 (39%), Gaps = 19/261 (7%)
Query: 81 VLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTA 140
+ VGG+D + ++E + + W A + + D +Y +GG
Sbjct: 408 LFAVGGMDSTKG-ATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-GLK 465
Query: 141 PQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEAR 200
V Y P+ W +P M T +G + +Y +GG G + E +D +AR
Sbjct: 466 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 525
Query: 201 TWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTK 260
W ++ + R+ G A+ G ++++GG + +VE FD WT
Sbjct: 526 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS---------CLKSVECFDPHTNKWT- 575
Query: 261 LPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGS-----VESFSLARRRWEALPAM 315
+M +R V + G + AIGG L S VE + W A+ +M
Sbjct: 576 --LCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASM 633
Query: 316 PTARCSCSSLQAGPRLFVIGG 336
+R + G +L+ +GG
Sbjct: 634 SISRDAVGVCLLGDKLYAVGG 654
Score = 28.9 bits (63), Expect = 7.3
Identities = 13/32 (40%), Positives = 18/32 (56%)
Query: 46 LDTAETLDMASHTWLALAPLPTARAGAAAVVL 77
L+T E D ++ W +APL RAGA V +
Sbjct: 661 LNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 692
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 85.9 bits (211), Expect = 5e-17
Identities = 62/210 (29%), Positives = 94/210 (44%), Gaps = 7/210 (3%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W V PPM T R VA +G + +GG L+T E D + W +A + T R+
Sbjct: 541 WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSY-LNTVERWDPQARQWNFVATMSTPRS 599
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVY 130
VL ++ VGG D S + +VE F +W A + + GV +G++Y
Sbjct: 600 TVGVAVLSGKLYAVGGRDG-SSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLY 658
Query: 131 ALGGMGPDTAPQAQ-----VRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQG 185
A+GG + V Y+P+ D W ++ SM L G+K+Y +GG G
Sbjct: 659 AIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDG 718
Query: 186 KLPVTAFEAFDLEARTWTRHPSLPSRRAFA 215
+ + EA+D + WT+ L RA A
Sbjct: 719 QAYLNTVEAYDPQTNEWTQVAPLCLGRAGA 748
Score = 79.3 bits (194), Expect = 5e-15
Identities = 66/260 (25%), Positives = 108/260 (41%), Gaps = 9/260 (3%)
Query: 50 ETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWER 109
E D+ ++ W +A + R VL ++ VVGG D +++ + VE + W
Sbjct: 485 EKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKT-LNTVECYNPKTKTWSV 543
Query: 110 RATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGAS 169
+ G+ +G +YA+GG + V ++P+ W + +M TP
Sbjct: 544 MPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERWDPQARQWNFVATMSTPRSTVG 602
Query: 170 TFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGG 229
+ K+Y +GGR G + + E FD WT + RR G G ++++GG
Sbjct: 603 VAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG 662
Query: 230 LQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGL 289
P N SR + VE +D + WT + RD V LG + A+GG
Sbjct: 663 HDAPA-SNLTSR--LSDCVERYDPKTDMWTAVASMSISRDAVG---VCLLGDKLYAVGGY 716
Query: 290 GNQPCPLGSVESFSLARRRW 309
Q L +VE++ W
Sbjct: 717 DGQ-AYLNTVEAYDPQTNEW 735
Score = 74.3 bits (181), Expect = 2e-13
Identities = 69/264 (26%), Positives = 109/264 (41%), Gaps = 24/264 (9%)
Query: 7 RAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLP-LDTAETLDMASHTWLALAPL 65
R W M R+ VA D L V+GG R GL L+T E + + TW + P+
Sbjct: 490 RTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG--RDGLKTLNTVECYNPKTKTWSVMPPM 547
Query: 66 PTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATL--PQAAMGVATV 123
T R G VL + VGG D S + VE + +W AT+ P++ +GVA +
Sbjct: 548 STHRHGLGVAVLEGPMYAVGGHDG-WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVL 606
Query: 124 ERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGR 183
G +YA+GG + ++ V ++P + W M G +Y +GG
Sbjct: 607 --SGKLYAVGGRDGSSCLKS-VECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGH 663
Query: 184 QGKLP------VTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHN 237
E +D + WT S+ R G + ++++GG
Sbjct: 664 DAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG-------- 715
Query: 238 FYSRPHFVNTVEMFDLEHGSWTKL 261
Y ++NTVE +D + WT++
Sbjct: 716 -YDGQAYLNTVEAYDPQTNEWTQV 738
Score = 73.6 bits (179), Expect = 3e-13
Identities = 60/261 (22%), Positives = 103/261 (39%), Gaps = 19/261 (7%)
Query: 81 VLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTA 140
+ VGG+D + ++E + + W A + + D +Y +GG
Sbjct: 469 LFAVGGMDSTKG-ATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-GLK 526
Query: 141 PQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEAR 200
V Y P+ W +P M T +G + +Y +GG G + E +D +AR
Sbjct: 527 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 586
Query: 201 TWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTK 260
W ++ + R+ G A+ G ++++GG + +VE FD WT
Sbjct: 587 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS---------CLKSVECFDPHTNKWT- 636
Query: 261 LPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGS-----VESFSLARRRWEALPAM 315
+M +R V + G + AIGG L S VE + W A+ +M
Sbjct: 637 --LCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASM 694
Query: 316 PTARCSCSSLQAGPRLFVIGG 336
+R + G +L+ +GG
Sbjct: 695 SISRDAVGVCLLGDKLYAVGG 715
Score = 28.9 bits (63), Expect = 7.3
Identities = 13/32 (40%), Positives = 18/32 (56%)
Query: 46 LDTAETLDMASHTWLALAPLPTARAGAAAVVL 77
L+T E D ++ W +APL RAGA V +
Sbjct: 722 LNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 753
>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
Length = 642
Score = 85.5 bits (210), Expect = 7e-17
Identities = 65/250 (26%), Positives = 98/250 (39%), Gaps = 11/250 (4%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W PM T R +A G L V+GG L E D W+ + L T R
Sbjct: 395 WSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRC 454
Query: 71 GAAAVVLGKQVLVVGGVDEV-QSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMV 129
A L ++ +VGG D Q + + F W A L A E G +
Sbjct: 455 NAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYL 514
Query: 130 YALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPV 189
Y +GG R Y P + W + M GA + K++V GG G +
Sbjct: 515 YIIGGAESWNCLNTVER-YNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAI 573
Query: 190 TAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVE 249
+ E +D W ++ S R+ AG A +++++GG + F+NTVE
Sbjct: 574 SCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGG---------FDGNEFLNTVE 624
Query: 250 MFDLEHGSWT 259
+++LE W+
Sbjct: 625 VYNLESNEWS 634
Score = 85.1 bits (209), Expect = 9e-17
Identities = 75/296 (25%), Positives = 120/296 (40%), Gaps = 17/296 (5%)
Query: 16 PMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAV 75
PM R A +G L+ GG R L T E + + W LAP+ T RA
Sbjct: 353 PMQYARSGLGTAEMNGKLIAAGGYNREEC-LRTVECYNPHTDHWSFLAPMRTPRARFQMA 411
Query: 76 VLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGM 135
VL Q+ VVGG + ++ E + + W L +G +Y +GG
Sbjct: 412 VLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGS 471
Query: 136 GP-DTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEA 194
P V++P W S + + ++ G +Y++GG + + E
Sbjct: 472 DPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVER 531
Query: 195 FDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLE 254
++ E TWT + R AG A+ G +F GG + H ++ VEM+D
Sbjct: 532 YNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGG---------FDGSHAISCVEMYDPT 582
Query: 255 HGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGL-GNQPCPLGSVESFSLARRRW 309
W + M R++ + ++G I A+GG GN+ L +VE ++L W
Sbjct: 583 RNEWKMMG---NMTSPRSNAGIATVGNTIYAVGGFDGNE--FLNTVEVYNLESNEW 633
Score = 75.9 bits (185), Expect = 5e-14
Identities = 52/199 (26%), Positives = 85/199 (42%), Gaps = 3/199 (1%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLP-LDTAETLDMASHTWLALAPLPTAR 69
W P + T R V +G L ++GG G L + D + W + APL R
Sbjct: 443 WIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRR 502
Query: 70 AGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMV 129
+A LG + ++GG E + + VE + + W A + A G +G +
Sbjct: 503 HQSAVCELGGYLYIIGGA-ESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKL 561
Query: 130 YALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPV 189
+ GG A V +Y+P R+ W + +M +P A GN IY +GG G +
Sbjct: 562 FVCGGFDGSHAISC-VEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFL 620
Query: 190 TAFEAFDLEARTWTRHPSL 208
E ++LE+ W+ + +
Sbjct: 621 NTVEVYNLESNEWSPYTKI 639
Score = 74.7 bits (182), Expect = 1e-13
Identities = 61/279 (21%), Positives = 115/279 (41%), Gaps = 20/279 (7%)
Query: 62 LAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATL--PQAAMG 119
++P+ AR+G + +++ GG + + + VE + W A + P+A
Sbjct: 351 MSPMQYARSGLGTAEMNGKLIAAGGYNREEC-LRTVECYNPHTDHWSFLAPMRTPRARFQ 409
Query: 120 VATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYV 179
+A + G +Y +GG + + +Y+ D W+ +P + T A K+Y+
Sbjct: 410 MAVLM--GQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYI 467
Query: 180 LGGRQ--GKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHN 237
+GG G+ + + FD + WT L RR + G ++ +GG +
Sbjct: 468 VGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESW---- 523
Query: 238 FYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLG 297
+ +NTVE ++ E+ +WT + M R V L G + GG +
Sbjct: 524 -----NCLNTVERYNPENNTWTLIAP---MNVARRGAGVAVLNGKLFVCGGFDGSHA-IS 574
Query: 298 SVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGG 336
VE + R W+ + M + R + G ++ +GG
Sbjct: 575 CVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGG 613
Score = 48.5 bits (114), Expect = 9e-06
Identities = 36/145 (24%), Positives = 60/145 (41%), Gaps = 14/145 (9%)
Query: 194 AFDLEARTWTRHPSLPSRRAFAGCAMAE--GSVFSLGGLQQPGPHNFYSRPHFVNTVEMF 251
+F+++ P P + A +G AE G + + GG Y+R + TVE +
Sbjct: 338 SFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGG---------YNREECLRTVECY 388
Query: 252 DLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEA 311
+ W+ L MR RA F + L G + +GG L E + W
Sbjct: 389 NPHTDHWSFLAP---MRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIP 445
Query: 312 LPAMPTARCSCSSLQAGPRLFVIGG 336
+P + T RC+ +L+++GG
Sbjct: 446 VPELRTNRCNAGVCALNGKLYIVGG 470
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 84.3 bits (207), Expect = 1e-16
Identities = 75/280 (26%), Positives = 117/280 (41%), Gaps = 10/280 (3%)
Query: 31 GHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEV 90
G L +GG A T E D+ +++WL + + R V+ ++ VVGG D +
Sbjct: 429 GALYAVGGMD-AMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGL 487
Query: 91 QSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEP 150
++ + VE F W + G+ +G +YA+GG + R ++P
Sbjct: 488 KT-LNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVER-WDP 545
Query: 151 RRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPS 210
W + SM TP NK+Y +GGR G + + E FD W+ +
Sbjct: 546 EGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSK 605
Query: 211 RRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDK 270
RR G A G ++ +GG P N SR + VE +D + SW+ + RD
Sbjct: 606 RRGGVGVATYNGFLYVVGGHDAPA-SNHCSR--LSDCVERYDPKGDSWSTVAPLSVPRDA 662
Query: 271 RADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWE 310
A V LG + +GG L +VES+ R W+
Sbjct: 663 VA---VCPLGDKLYVVGGYDGHTY-LNTVESYDAQRNEWK 698
Score = 77.0 bits (188), Expect = 2e-14
Identities = 52/197 (26%), Positives = 85/197 (43%), Gaps = 7/197 (3%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W V PPM T R VA +G + +GG L+T E D W +A + T R+
Sbjct: 503 WTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSY-LNTVERWDPEGRQWNYVASMSTPRS 561
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVY 130
V L ++ +GG D S + ++E F +W A + + GV +G +Y
Sbjct: 562 TVGVVALNNKLYAIGGRDG-SSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLY 620
Query: 131 ALGGMGPDTAPQAQ-----VRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQG 185
+GG + V Y+P+ D W ++ + P + G+K+YV+GG G
Sbjct: 621 VVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDG 680
Query: 186 KLPVTAFEAFDLEARTW 202
+ E++D + W
Sbjct: 681 HTYLNTVESYDAQRNEW 697
Score = 63.9 bits (154), Expect = 2e-10
Identities = 68/284 (23%), Positives = 111/284 (39%), Gaps = 72/284 (25%)
Query: 108 ERRATL--PQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPC 165
ERR+ + P+ +TV G +YA+GGM + Y+ R + WL + +M
Sbjct: 411 ERRSMMQSPRTKPRKSTV---GALYAVGGMDAMKGTTT-IEKYDLRTNSWLHIGTMNGRR 466
Query: 166 YGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVF 225
+ NK+YV+GGR G + E F+ + WT P + + R G A EG ++
Sbjct: 467 LQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMY 526
Query: 226 SLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVA 285
++GG H+ +S ++NTVE +D E W + M R+ V +L + A
Sbjct: 527 AVGG------HDGWS---YLNTVERWDPEGRQWNYVAS---MSTPRSTVGVVALNNKLYA 574
Query: 286 IGGLGNQPCPLGSVESFS-----------LARRR-------------------------- 308
IGG C L S+E F +++RR
Sbjct: 575 IGGRDGSSC-LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHC 633
Query: 309 ----------------WEALPAMPTARCSCSSLQAGPRLFVIGG 336
W + + R + + G +L+V+GG
Sbjct: 634 SRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG 677
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 84.3 bits (207), Expect = 1e-16
Identities = 75/280 (26%), Positives = 117/280 (41%), Gaps = 10/280 (3%)
Query: 31 GHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEV 90
G L +GG A T E D+ +++WL + + R V+ ++ VVGG D +
Sbjct: 429 GALYAVGGMD-AMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGL 487
Query: 91 QSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEP 150
++ + VE F W + G+ +G +YA+GG + R ++P
Sbjct: 488 KT-LNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVER-WDP 545
Query: 151 RRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPS 210
W + SM TP NK+Y +GGR G + + E FD W+ +
Sbjct: 546 EGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSK 605
Query: 211 RRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDK 270
RR G A G ++ +GG P N SR + VE +D + SW+ + RD
Sbjct: 606 RRGGVGVATYNGFLYVVGGHDAPA-SNHCSR--LSDCVERYDPKGDSWSTVAPLSVPRDA 662
Query: 271 RADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWE 310
A V LG + +GG L +VES+ R W+
Sbjct: 663 VA---VCPLGDKLYVVGGYDGHTY-LNTVESYDAQRNEWK 698
Score = 77.4 bits (189), Expect = 2e-14
Identities = 55/210 (26%), Positives = 89/210 (42%), Gaps = 7/210 (3%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W V PPM T R VA +G + +GG L+T E D W +A + T R+
Sbjct: 503 WTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSY-LNTVERWDPEGRQWNYVASMSTPRS 561
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVY 130
V L ++ +GG D S + ++E F +W A + + GV +G +Y
Sbjct: 562 TVGVVALNNKLYAIGGRDG-SSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLY 620
Query: 131 ALGGMGPDTAPQAQ-----VRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQG 185
+GG + V Y+P+ D W ++ + P + G+K+YV+GG G
Sbjct: 621 VVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDG 680
Query: 186 KLPVTAFEAFDLEARTWTRHPSLPSRRAFA 215
+ E++D + W + RA A
Sbjct: 681 HTYLNTVESYDAQRNEWKEEVPVNIGRAGA 710
Score = 63.9 bits (154), Expect = 2e-10
Identities = 68/284 (23%), Positives = 111/284 (39%), Gaps = 72/284 (25%)
Query: 108 ERRATL--PQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPC 165
ERR+ + P+ +TV G +YA+GGM + Y+ R + WL + +M
Sbjct: 411 ERRSMMQSPRTKPRKSTV---GALYAVGGMDAMKGTTT-IEKYDLRTNSWLHIGTMNGRR 466
Query: 166 YGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVF 225
+ NK+YV+GGR G + E F+ + WT P + + R G A EG ++
Sbjct: 467 LQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMY 526
Query: 226 SLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVA 285
++GG H+ +S ++NTVE +D E W + M R+ V +L + A
Sbjct: 527 AVGG------HDGWS---YLNTVERWDPEGRQWNYVAS---MSTPRSTVGVVALNNKLYA 574
Query: 286 IGGLGNQPCPLGSVESFS-----------LARRR-------------------------- 308
IGG C L S+E F +++RR
Sbjct: 575 IGGRDGSSC-LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHC 633
Query: 309 ----------------WEALPAMPTARCSCSSLQAGPRLFVIGG 336
W + + R + + G +L+V+GG
Sbjct: 634 SRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG 677
Score = 29.3 bits (64), Expect = 5.6
Identities = 20/68 (29%), Positives = 28/68 (41%), Gaps = 1/68 (1%)
Query: 10 AWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTAR 69
+W P+ R V L V+GG L+T E+ D + W P+ R
Sbjct: 649 SWSTVAPLSVPRDAVAVCPLGDKLYVVGGYD-GHTYLNTVESYDAQRNEWKEEVPVNIGR 707
Query: 70 AGAAAVVL 77
AGA VV+
Sbjct: 708 AGACVVVV 715
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 84.0 bits (206), Expect = 2e-16
Identities = 75/294 (25%), Positives = 125/294 (42%), Gaps = 22/294 (7%)
Query: 31 GHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVD-- 88
G L+ G G L E + + TWL LA L R+G A V+G + VGG +
Sbjct: 325 GRLIYTAG-GYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNS 383
Query: 89 -EVQSPVAAVEAFLMDEGRWERRA--TLPQAAMGVATVERDGMVYALGGMGPDTAPQAQV 145
+ + +A++ + +W A ++P+ +GV + DG +YA+GG V
Sbjct: 384 PDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVI--DGHIYAVGG-SHGCIHHNSV 440
Query: 146 RVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRH 205
YEP RD W + M T G + +Y +GG G + + E + E W
Sbjct: 441 ERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMI 500
Query: 206 PSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSL 265
++ + R+ AG + +++ GG Y +N+VE +D+E +WT +
Sbjct: 501 TAMNTIRSGAGVCVLHNCIYAAGG---------YDGQDQLNSVERYDVETETWTFV---A 548
Query: 266 RMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTAR 319
M+ +R+ + G I +GG L SVE + W + M + R
Sbjct: 549 PMKHRRSALGITVHQGRIYVLGGYDGHTF-LDSVECYDPDTDTWSEVTRMTSGR 601
Score = 68.9 bits (167), Expect = 6e-12
Identities = 65/274 (23%), Positives = 108/274 (39%), Gaps = 18/274 (6%)
Query: 66 PTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVER 125
PT A +G+ + GG + ++ +EA+ +G W R A L G+A
Sbjct: 313 PTQVMPCRAPKVGRLIYTAGGY--FRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVV 370
Query: 126 DGMVYALGGMG--PD-TAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGG 182
G++YA+GG PD + + Y P + W M P + IY +GG
Sbjct: 371 GGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGG 430
Query: 183 RQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRP 242
G + + E ++ E W + +RR G A+ ++++GG +
Sbjct: 431 SHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGG---------FDGT 481
Query: 243 HFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESF 302
+ +N+ E + E W + M R+ V L I A GG Q L SVE +
Sbjct: 482 NRLNSAECYYPERNEWRMI---TAMNTIRSGAGVCVLHNCIYAAGGYDGQD-QLNSVERY 537
Query: 303 SLARRRWEALPAMPTARCSCSSLQAGPRLFVIGG 336
+ W + M R + R++V+GG
Sbjct: 538 DVETETWTFVAPMKHRRSALGITVHQGRIYVLGG 571
Score = 68.9 bits (167), Expect = 6e-12
Identities = 52/210 (24%), Positives = 81/210 (38%), Gaps = 5/210 (2%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W PM R V DGH+ +GG + ++ E + W +AP+ T R
Sbjct: 403 WSPCAPMSVPRNRIGVGVIDGHIYAVGG-SHGCIHHNSVERYEPERDEWHLVAPMLTRRI 461
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVY 130
G VL + + VGG D + + E + + W + G +Y
Sbjct: 462 GVGVAVLNRLLYAVGGFDGTNR-LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIY 520
Query: 131 ALGGM-GPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPV 189
A GG G D V Y+ + W + M +H +IYVLGG G +
Sbjct: 521 AAGGYDGQDQLNS--VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL 578
Query: 190 TAFEAFDLEARTWTRHPSLPSRRAFAGCAM 219
+ E +D + TW+ + S R+ G A+
Sbjct: 579 DSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 84.0 bits (206), Expect = 2e-16
Identities = 75/294 (25%), Positives = 125/294 (42%), Gaps = 22/294 (7%)
Query: 31 GHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVD-- 88
G L+ G G L E + + TWL LA L R+G A V+G + VGG +
Sbjct: 325 GRLIYTAG-GYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNS 383
Query: 89 -EVQSPVAAVEAFLMDEGRWERRA--TLPQAAMGVATVERDGMVYALGGMGPDTAPQAQV 145
+ + +A++ + +W A ++P+ +GV + DG +YA+GG V
Sbjct: 384 PDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVI--DGHIYAVGG-SHGCIHHNSV 440
Query: 146 RVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRH 205
YEP RD W + M T G + +Y +GG G + + E + E W
Sbjct: 441 ERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMI 500
Query: 206 PSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSL 265
++ + R+ AG + +++ GG Y +N+VE +D+E +WT +
Sbjct: 501 TAMNTIRSGAGVCVLHNCIYAAGG---------YDGQDQLNSVERYDVETETWTFV---A 548
Query: 266 RMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTAR 319
M+ +R+ + G I +GG L SVE + W + M + R
Sbjct: 549 PMKHRRSALGITVHQGRIYVLGGYDGHTF-LDSVECYDPDTDTWSEVTRMTSGR 601
Score = 68.9 bits (167), Expect = 6e-12
Identities = 65/274 (23%), Positives = 108/274 (39%), Gaps = 18/274 (6%)
Query: 66 PTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVER 125
PT A +G+ + GG + ++ +EA+ +G W R A L G+A
Sbjct: 313 PTQVMPCRAPKVGRLIYTAGGY--FRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVV 370
Query: 126 DGMVYALGGMG--PD-TAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGG 182
G++YA+GG PD + + Y P + W M P + IY +GG
Sbjct: 371 GGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGG 430
Query: 183 RQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRP 242
G + + E ++ E W + +RR G A+ ++++GG +
Sbjct: 431 SHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGG---------FDGT 481
Query: 243 HFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESF 302
+ +N+ E + E W + M R+ V L I A GG Q L SVE +
Sbjct: 482 NRLNSAECYYPERNEWRMI---TAMNTIRSGAGVCVLHNCIYAAGGYDGQD-QLNSVERY 537
Query: 303 SLARRRWEALPAMPTARCSCSSLQAGPRLFVIGG 336
+ W + M R + R++V+GG
Sbjct: 538 DVETETWTFVAPMKHRRSALGITVHQGRIYVLGG 571
Score = 68.9 bits (167), Expect = 6e-12
Identities = 52/210 (24%), Positives = 81/210 (38%), Gaps = 5/210 (2%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W PM R V DGH+ +GG + ++ E + W +AP+ T R
Sbjct: 403 WSPCAPMSVPRNRIGVGVIDGHIYAVGG-SHGCIHHNSVERYEPERDEWHLVAPMLTRRI 461
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVY 130
G VL + + VGG D + + E + + W + G +Y
Sbjct: 462 GVGVAVLNRLLYAVGGFDGTNR-LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIY 520
Query: 131 ALGGM-GPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPV 189
A GG G D V Y+ + W + M +H +IYVLGG G +
Sbjct: 521 AAGGYDGQDQLNS--VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL 578
Query: 190 TAFEAFDLEARTWTRHPSLPSRRAFAGCAM 219
+ E +D + TW+ + S R+ G A+
Sbjct: 579 DSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 84.0 bits (206), Expect = 2e-16
Identities = 59/201 (29%), Positives = 84/201 (41%), Gaps = 3/201 (1%)
Query: 16 PMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAV 75
P TCR VA G L +GG L+ E D + W +A + T R G A
Sbjct: 398 PTSTCRTSVGVAVLGGFLYAVGGQDGVSC-LNIVERYDPKENKWTRVASMSTRRLGVAVA 456
Query: 76 VLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGM 135
VLG + VGG D SP+ VE + E RW A + + M+YA+GG
Sbjct: 457 VLGGFLYAVGGSDGT-SPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGR 515
Query: 136 GPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAF 195
DT + Y PR + W + +M + G + ++ +GG G + E F
Sbjct: 516 D-DTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVF 574
Query: 196 DLEARTWTRHPSLPSRRAFAG 216
D +A TW + + RR G
Sbjct: 575 DPDANTWRLYGGMNYRRLGGG 595
Score = 79.7 bits (195), Expect = 4e-15
Identities = 64/288 (22%), Positives = 122/288 (42%), Gaps = 20/288 (6%)
Query: 31 GHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEV 90
G +L G +G + + E D ++ W +A + R G VL + VGG D
Sbjct: 317 GEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDG- 375
Query: 91 QSPVAAVEAFLMDEGRWERRA---TLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRV 147
S + +VE + +W + + ++GVA + G +YA+GG + R
Sbjct: 376 SSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVL--GGFLYAVGGQDGVSCLNIVER- 432
Query: 148 YEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPS 207
Y+P+ + W + SM T G + + G +Y +GG G P+ E ++ + W
Sbjct: 433 YDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAP 492
Query: 208 LPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRM 267
+ +RR GCA+ + ++++GG +++ E ++ W+ + + M
Sbjct: 493 MGTRRKHLGCAVYQDMIYAVGGRDDTTE---------LSSAERYNPRTNQWSPV---VAM 540
Query: 268 RDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAM 315
+R+ + + G ++A+GG L ++E F W M
Sbjct: 541 TSRRSGVGLAVVNGQLMAVGGFDGTTY-LKTIEVFDPDANTWRLYGGM 587
Score = 73.2 bits (178), Expect = 3e-13
Identities = 60/260 (23%), Positives = 109/260 (41%), Gaps = 16/260 (6%)
Query: 78 GKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGP 137
G+ + VGG + +++VE + W A++ + GV D ++YA+GG
Sbjct: 317 GEVLFAVGGWCSGDA-ISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDG 375
Query: 138 DTAPQAQVRVYEPRRDCWLSLPSMPTPCY-GASTFLHGNKIYVLGGRQGKLPVTAFEAFD 196
+ + R Y+P+ + W S + + C + G +Y +GG+ G + E +D
Sbjct: 376 SSYLNSVER-YDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYD 434
Query: 197 LEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHG 256
+ WTR S+ +RR A+ G ++++GG P +NTVE ++ +
Sbjct: 435 PKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSP---------LNTVERYNPQEN 485
Query: 257 SWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMP 316
W + M +R I A+GG + L S E ++ +W + AM
Sbjct: 486 RWHTIAP---MGTRRKHLGCAVYQDMIYAVGGR-DDTTELSSAERYNPRTNQWSPVVAMT 541
Query: 317 TARCSCSSLQAGPRLFVIGG 336
+ R +L +GG
Sbjct: 542 SRRSGVGLAVVNGQLMAVGG 561
>gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Homo
sapiens]
Length = 606
Score = 82.8 bits (203), Expect = 4e-16
Identities = 60/252 (23%), Positives = 102/252 (40%), Gaps = 6/252 (2%)
Query: 21 RVYGTVAHQDGHLLVLGGC----GRAGLPLDTAE-TLDMASHTWLALAPLPTARAGAAAV 75
R + ++ Q + V+GG PL + LD + W+ L PLP+AR
Sbjct: 335 RNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLG 394
Query: 76 VLGKQVLVVGGVD-EVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGG 134
+ ++ VV G D + ++ + +V + +W LP G + GM+Y LGG
Sbjct: 395 EVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGG 454
Query: 135 MGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEA 194
D +V ++ P++ W L M P +H KI + GG + EA
Sbjct: 455 KTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEA 514
Query: 195 FDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLE 254
FDL W P R+ GS++++GG + P VN + ++ +
Sbjct: 515 FDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDD 574
Query: 255 HGSWTKLPRSLR 266
W + + +R
Sbjct: 575 KKEWAGMLKEIR 586
Score = 58.9 bits (141), Expect = 7e-09
Identities = 57/223 (25%), Positives = 91/223 (40%), Gaps = 19/223 (8%)
Query: 123 VERDGMVYALGGMGPDTAPQAQ-VRVYEPRRDC----WLSLPSMPTPCYGASTFLHGNKI 177
V + +Y +GG+ D + Q ++ Y + D W+ LP +P+ +KI
Sbjct: 341 VTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKI 400
Query: 178 YVLGGR--QGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGP 235
YV+ G+ Q + + + +D A W LP + +G ++ LGG
Sbjct: 401 YVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDD-- 458
Query: 236 HNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCP 295
N V +F+ + G W L M+ R+ F V G IV GG+
Sbjct: 459 ------KKCTNRVFIFNPKKGDWKDLAP---MKIPRSMFGVAVHKGKIVIAGGVTEDGLS 509
Query: 296 LGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVA 338
SVE+F L +W+ + P R S S + L+ IGG A
Sbjct: 510 -ASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFA 551
Score = 37.0 bits (84), Expect = 0.027
Identities = 21/81 (25%), Positives = 35/81 (43%), Gaps = 1/81 (1%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W+ PM R VA G +++ GG GL + E D+ ++ W + P R+
Sbjct: 475 WKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSA-SVEAFDLTTNKWDVMTEFPQERS 533
Query: 71 GAAAVVLGKQVLVVGGVDEVQ 91
+ V L + +GG +Q
Sbjct: 534 SISLVSLAGSLYAIGGFAMIQ 554
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 82.4 bits (202), Expect = 6e-16
Identities = 58/210 (27%), Positives = 92/210 (43%), Gaps = 7/210 (3%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W V PPM T R V +G + +GG L+T E D S W +A + AR+
Sbjct: 533 WTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSY-LNTVERWDPQSQQWTFVASMSIARS 591
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVY 130
L ++ VGG D S ++++E + +W A + + GV DG +Y
Sbjct: 592 TVGVAALNGKLYSVGGRDG-SSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLY 650
Query: 131 ALGGMGPDTAPQAQ-----VRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQG 185
A+GG + V Y+P+ D W + + P L G+++Y +GG G
Sbjct: 651 AVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDG 710
Query: 186 KLPVTAFEAFDLEARTWTRHPSLPSRRAFA 215
+ + E++D + WT+ SL RA A
Sbjct: 711 QTYLNTMESYDPQTNEWTQMASLNIGRAGA 740
Score = 77.0 bits (188), Expect = 2e-14
Identities = 63/272 (23%), Positives = 113/272 (41%), Gaps = 9/272 (3%)
Query: 48 TAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRW 107
T E D+ ++ W+ + R V+ ++ V+GG D +++ + VE + W
Sbjct: 475 TIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKT-LNTVECYNPKTKTW 533
Query: 108 ERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYG 167
+ G+ +G +YA+GG + V ++P+ W + SM
Sbjct: 534 TVLPPMSTHRHGLGVTVLEGPIYAVGG-HDGWSYLNTVERWDPQSQQWTFVASMSIARST 592
Query: 168 ASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSL 227
K+Y +GGR G +++ E +D W + RR G A +G ++++
Sbjct: 593 VGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAV 652
Query: 228 GGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIG 287
GG P N SR ++ VE +D + +WT + RD V LG + A+G
Sbjct: 653 GGHDAPA-SNHCSR--LLDYVERYDPKTDTWTMVAPLSMPRDAVG---VCLLGDRLYAVG 706
Query: 288 GLGNQPCPLGSVESFSLARRRWEALPAMPTAR 319
G Q L ++ES+ W + ++ R
Sbjct: 707 GYDGQTY-LNTMESYDPQTNEWTQMASLNIGR 737
Score = 70.5 bits (171), Expect = 2e-12
Identities = 67/268 (25%), Positives = 106/268 (39%), Gaps = 30/268 (11%)
Query: 26 VAHQDGHLLVLGGCGRAGLP-LDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVV 84
VA D L V+GG R GL L+T E + + TW L P+ T R G VL + V
Sbjct: 501 VAVIDDKLFVIGG--RDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAV 558
Query: 85 GGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQ 144
GG D S + VE + +W A++ A V +G +Y++GG + +
Sbjct: 559 GGHDG-WSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSC-LSS 616
Query: 145 VRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLP------VTAFEAFDLE 198
+ Y+P + W M G +Y +GG + E +D +
Sbjct: 617 MEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPK 676
Query: 199 ARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSW 258
TWT L R G + ++++GG Y ++NT+E +D + W
Sbjct: 677 TDTWTMVAPLSMPRDAVGVCLLGDRLYAVGG---------YDGQTYLNTMESYDPQTNEW 727
Query: 259 TKLPRSLRMRDKRADFVVGSLGGHIVAI 286
T++ A +G G +V I
Sbjct: 728 TQM----------ASLNIGRAGACVVVI 745
Score = 63.2 bits (152), Expect = 3e-10
Identities = 56/258 (21%), Positives = 97/258 (37%), Gaps = 19/258 (7%)
Query: 84 VGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQA 143
VGG+D + +E + + W + + + D ++ +GG
Sbjct: 464 VGGMDNNKG-ATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRD-GLKTLN 521
Query: 144 QVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWT 203
V Y P+ W LP M T +G + IY +GG G + E +D +++ WT
Sbjct: 522 TVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWT 581
Query: 204 RHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPR 263
S+ R+ G A G ++S+GG ++++E +D W
Sbjct: 582 FVASMSIARSTVGVAALNGKLYSVGGRDGSS---------CLSSMEYYDPHTNKWN---M 629
Query: 264 SLRMRDKRADFVVGSLGGHIVAIGG---LGNQPCP--LGSVESFSLARRRWEALPAMPTA 318
M +R V + G + A+GG + C L VE + W + +
Sbjct: 630 CAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMP 689
Query: 319 RCSCSSLQAGPRLFVIGG 336
R + G RL+ +GG
Sbjct: 690 RDAVGVCLLGDRLYAVGG 707
Score = 54.7 bits (130), Expect = 1e-07
Identities = 43/160 (26%), Positives = 69/160 (43%), Gaps = 13/160 (8%)
Query: 177 IYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPH 236
+Y +GG T E +DL W + + RR G A+ + +F +GG + G
Sbjct: 461 LYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGG--RDGLK 518
Query: 237 NFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPL 296
+NTVE ++ + +WT LP M R V L G I A+GG L
Sbjct: 519 T-------LNTVECYNPKTKTWTVLP---PMSTHRHGLGVTVLEGPIYAVGGHDGWSY-L 567
Query: 297 GSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGG 336
+VE + ++W + +M AR + +L+ +GG
Sbjct: 568 NTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGG 607
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 82.4 bits (202), Expect = 6e-16
Identities = 66/267 (24%), Positives = 111/267 (41%), Gaps = 25/267 (9%)
Query: 79 KQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATL--PQAAMGVATVERDGMVYALGGMG 136
K + VGG + + + +VE + W A L P+ G+ + D VY +GG+
Sbjct: 283 KVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVL--DQKVYVIGGIA 340
Query: 137 PDTAPQAQVRVYEPRRDCW-------LSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPV 189
+ P +R +E +CW SL M + ++Y LGG G+ +
Sbjct: 341 TNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYL 400
Query: 190 TAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVE 249
+ E + + R W + + R+ A+ +G ++++GG P +N+VE
Sbjct: 401 QSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY----------GPAHMNSVE 450
Query: 250 MFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRW 309
+D SW + M DKR F VG + G I +GG N L S+E + + +W
Sbjct: 451 RYDPSKDSWEMV---ASMADKRIHFGVGVMLGFIFVVGG-HNGVSHLSSIERYDPHQNQW 506
Query: 310 EALPAMPTARCSCSSLQAGPRLFVIGG 336
M R + L+V+GG
Sbjct: 507 TVCRPMKEPRTGVGAAVIDNYLYVVGG 533
Score = 72.8 bits (177), Expect = 4e-13
Identities = 70/293 (23%), Positives = 120/293 (40%), Gaps = 28/293 (9%)
Query: 40 GRAGL--PLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVD-------EV 90
G++GL LD+ E + +W+ LAPL R VL ++V V+GG+ +
Sbjct: 290 GKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTI 349
Query: 91 QSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEP 150
+ +VE + D W + ++ + V G +YALGG + Q+ V Y P
Sbjct: 350 RKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQS-VEKYIP 408
Query: 151 RRDCWLSLPSMPT--PCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSL 208
+ W + M T C+ A+ IY +GG G + + E +D +W S+
Sbjct: 409 KIRKWQPVAPMTTTRSCFAAAVL--DGMIYAIGG-YGPAHMNSVERYDPSKDSWEMVASM 465
Query: 209 PSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMR 268
+R G + G +F +GG HN S ++++E +D WT M+
Sbjct: 466 ADKRIHFGVGVMLGFIFVVGG------HNGVSH---LSSIERYDPHQNQWTV---CRPMK 513
Query: 269 DKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTARCS 321
+ R + ++ +GG L +V+ + W M RC+
Sbjct: 514 EPRTGVGAAVIDNYLYVVGGHSGSSY-LNTVQKYDPISDTWLDSAGMIYCRCN 565
Score = 58.5 bits (140), Expect = 9e-09
Identities = 54/245 (22%), Positives = 93/245 (37%), Gaps = 53/245 (21%)
Query: 10 AWQVFPPMPTCRVYGTVAHQDGHLLVLGGCG---RAGLPL----DTAETLDMASHTWLAL 62
+W P+ R + D + V+GG R G+ + ++ E + ++TW +L
Sbjct: 310 SWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSL 369
Query: 63 APLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVAT 122
+ +R+ VVL ++ +GG D QS + +VE ++ +W+ A + A
Sbjct: 370 ERMNESRSTLGVVVLAGELYALGGYDG-QSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAA 428
Query: 123 VERDGMVYALGGMGPD-----------------TAPQAQVRV------------------ 147
DGM+YA+GG GP A A R+
Sbjct: 429 AVLDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHN 488
Query: 148 ----------YEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDL 197
Y+P ++ W M P G + N +YV+GG G + + +D
Sbjct: 489 GVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDP 548
Query: 198 EARTW 202
+ TW
Sbjct: 549 ISDTW 553
Score = 53.9 bits (128), Expect = 2e-07
Identities = 40/151 (26%), Positives = 66/151 (43%), Gaps = 4/151 (2%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
WQ PM T R A DG + +GG G A +++ E D + +W +A + R
Sbjct: 413 WQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPA--HMNSVERYDPSKDSWEMVASMADKRI 470
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVY 130
V+ + VVGG + V S ++++E + + +W + + GV D +Y
Sbjct: 471 HFGVGVMLGFIFVVGGHNGV-SHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLY 529
Query: 131 ALGGMGPDTAPQAQVRVYEPRRDCWLSLPSM 161
+GG + V+ Y+P D WL M
Sbjct: 530 VVGGHSGSSYLNT-VQKYDPISDTWLDSAGM 559
Score = 50.8 bits (120), Expect = 2e-06
Identities = 43/168 (25%), Positives = 73/168 (43%), Gaps = 6/168 (3%)
Query: 180 LGGRQGKLP-VTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNF 238
+GG+ G + + E + + +W L R G + + V+ +GG+
Sbjct: 288 VGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGV 347
Query: 239 YSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGS 298
R H N+VE ++ + +WT L R M + R+ V L G + A+GG Q L S
Sbjct: 348 TIRKH-ENSVECWNPDTNTWTSLER---MNESRSTLGVVVLAGELYALGGYDGQSY-LQS 402
Query: 299 VESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQGPSQAVE 346
VE + R+W+ + M T R ++ ++ IGG +VE
Sbjct: 403 VEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAHMNSVE 450
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 81.3 bits (199), Expect = 1e-15
Identities = 69/250 (27%), Positives = 109/250 (43%), Gaps = 23/250 (9%)
Query: 92 SPVAAVEAFLMDEGRWER---RATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQ-VRV 147
SP A+EA+ RW P+A G A ++ G VY +GG D+ V+
Sbjct: 303 SPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLK--GYVYIIGGF--DSVDYFNSVKR 358
Query: 148 YEPRRDCWLSLPSMPTP-CYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHP 206
++P + W + M + CY + T L GN IY +GG G + + E ++ E WT
Sbjct: 359 FDPVKKTWHQVAPMHSRRCYVSVTVL-GNFIYAMGGFDGYVRLNTAERYEPETNQWTLIA 417
Query: 207 SLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLR 266
+ +R+ A G V+ GG ++ + T E+++ E WT +
Sbjct: 418 PMHEQRSDASATTLYGKVYICGG---------FNGNECLFTAEVYNTESNQWTVIAP--- 465
Query: 267 MRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTARCSCSSLQ 326
MR +R+ V + G H+ A+GG L S E++S W +P M R +
Sbjct: 466 MRSRRSGIGVIAYGEHVYAVGGFDGAN-RLRSAEAYSPVANTWRTIPTMFNPRSNFGIEV 524
Query: 327 AGPRLFVIGG 336
LFV+GG
Sbjct: 525 VDDLLFVVGG 534
Score = 68.6 bits (166), Expect = 8e-12
Identities = 47/209 (22%), Positives = 86/209 (41%), Gaps = 3/209 (1%)
Query: 21 RVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQ 80
R Y A+ G++ ++GG ++ + D TW +AP+ + R + VLG
Sbjct: 329 RAYHGAAYLKGYVYIIGGFDSVDY-FNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNF 387
Query: 81 VLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTA 140
+ +GG D + E + + +W A + + + G VY GG +
Sbjct: 388 IYAMGGFDGYVR-LNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNEC 446
Query: 141 PQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEAR 200
VY + W + M + G +G +Y +GG G + + EA+ A
Sbjct: 447 -LFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVAN 505
Query: 201 TWTRHPSLPSRRAFAGCAMAEGSVFSLGG 229
TW P++ + R+ G + + +F +GG
Sbjct: 506 TWRTIPTMFNPRSNFGIEVVDDLLFVVGG 534
Score = 66.2 bits (160), Expect = 4e-11
Identities = 50/213 (23%), Positives = 90/213 (42%), Gaps = 5/213 (2%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 70
W PM + R Y +V + +GG + L+TAE + ++ W +AP+ R+
Sbjct: 366 WHQVAPMHSRRCYVSVTVLGNFIYAMGGFD-GYVRLNTAERYEPETNQWTLIAPMHEQRS 424
Query: 71 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVY 130
A+A L +V + GG + + A E + + +W A + G+ + VY
Sbjct: 425 DASATTLYGKVYICGGFNGNECLFTA-EVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVY 483
Query: 131 ALGGM-GPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPV 189
A+GG G + A+ Y P + W ++P+M P + + ++V+GG G
Sbjct: 484 AVGGFDGANRLRSAEA--YSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTT 541
Query: 190 TAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEG 222
E +D + W + R+ C + G
Sbjct: 542 FNVECYDEKTDEWYDAHDMSIYRSALSCCVVPG 574
Score = 54.7 bits (130), Expect = 1e-07
Identities = 41/161 (25%), Positives = 67/161 (41%), Gaps = 14/161 (8%)
Query: 177 IYVLGGRQGKLPVTAFEAFDLEARTWTRHP-SLPSRRAFAGCAMAEGSVFSLGGLQQPGP 235
++ +GG G P A EA+D A W S RA+ G A +G V+ +GG
Sbjct: 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGG------ 346
Query: 236 HNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCP 295
+ + N+V+ FD +W ++ M +R V LG I A+GG
Sbjct: 347 ---FDSVDYFNSVKRFDPVKKTWHQV---APMHSRRCYVSVTVLGNFIYAMGGFDGY-VR 399
Query: 296 LGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGG 336
L + E + +W + M R S+ ++++ GG
Sbjct: 400 LNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGG 440
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 75.5 bits (184), Expect = 7e-14
Identities = 58/230 (25%), Positives = 104/230 (45%), Gaps = 12/230 (5%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGG-----CGRAGLPLDTAETLDMASHTWLALAPL 65
W PMP R + VA L V GG GR + TA D S++W +AP+
Sbjct: 326 WSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRT-CAVRTACRYDPRSNSWAEIAPM 384
Query: 66 PTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVER 125
R + + + VGG +E++ + VE + + +W + ++ A
Sbjct: 385 KNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVA 444
Query: 126 DGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGG--- 182
DG+++ GG+ Q ++ VYEP ++ W+S M S K+YVLGG
Sbjct: 445 DGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDL 504
Query: 183 --RQGKLPVTAFEAFDLEARTWTR-HPSLPSRRAFAGCAMAEGSVFSLGG 229
++ V ++++++ WTR + +L + + +G A+ G ++ +GG
Sbjct: 505 DYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGG 554
Score = 52.4 bits (124), Expect = 6e-07
Identities = 59/290 (20%), Positives = 109/290 (37%), Gaps = 29/290 (10%)
Query: 45 PLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGG-VDEVQSPVAAVEAFLMD 103
P+D L A W LAP+P R+ V+G + V GG V+ AV
Sbjct: 312 PVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRY 371
Query: 104 EGR---WERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPS 160
+ R W A + + +YA+GG V Y P+++ W + S
Sbjct: 372 DPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQS 431
Query: 161 MPTPCYGASTFLHGNKIYVLGG------RQGKLPVTAFEAFDLEARTWTRHPSLPSRRAF 214
+ ++ +++ GG Q +L V ++ W + RR +
Sbjct: 432 FDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMV-----YEPNQNKWISRSPMLQRRVY 486
Query: 215 AGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADF 274
A + ++ LGG ++ + V ++ ++++ WT+ +L +
Sbjct: 487 HSMAAVQRKLYVLGG----NDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGV 542
Query: 275 VVGSLGGHIVAIGGLG---NQPCPLGSVESFSLARRRWEAL---PAMPTA 318
V + G I +GG N+ PL ++ ++R E + P +P A
Sbjct: 543 AVHN--GRIYLVGGYSIWTNE--PLACIQVLDVSREGKEEVFYGPTLPFA 588
Score = 40.4 bits (93), Expect = 0.002
Identities = 36/171 (21%), Positives = 70/171 (40%), Gaps = 17/171 (9%)
Query: 177 IYVLGGRQGKL----------PVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFS 226
+Y++GG++ ++ PV A W+ +P R+ A+ +F
Sbjct: 291 LYIIGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFV 350
Query: 227 LGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAI 286
GG + R V T +D SW ++ M++ R FV+G++ ++ A+
Sbjct: 351 AGGEVEHAS----GRTCAVRTACRYDPRSNSWAEIAP---MKNCREHFVLGAMEEYLYAV 403
Query: 287 GGLGNQPCPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGV 337
GG L +VE + + +W + + + + A L++ GGV
Sbjct: 404 GGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGV 454
Score = 39.3 bits (90), Expect = 0.005
Identities = 38/183 (20%), Positives = 70/183 (38%), Gaps = 9/183 (4%)
Query: 7 RAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLP 66
R+ +W PM CR + + + +L +GG L T E + W +
Sbjct: 374 RSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFD 433
Query: 67 TARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAM--GVATVE 124
+ + A V + + GGV + + ++ +W R+ + Q + +A V+
Sbjct: 434 RSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQ 493
Query: 125 RDGMVYALGG----MGPDTAPQAQVRVYEPRRDCWLSLP-SMPTPCYGASTFLHGNKIYV 179
R +Y LGG D + Y D W ++ T + +H +IY+
Sbjct: 494 R--KLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYL 551
Query: 180 LGG 182
+GG
Sbjct: 552 VGG 554
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 74.3 bits (181), Expect = 2e-13
Identities = 64/262 (24%), Positives = 112/262 (42%), Gaps = 22/262 (8%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGR----AGLPLDTAETLDMASHTWLALAPLP 66
W++ MP + V + L VLGG + + D ++W+ L P+
Sbjct: 352 WKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQ 411
Query: 67 TARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERD 126
RA A L K + V+GG +E +++VE + ++ W ++LPQ A +
Sbjct: 412 ERRASFYACRLDKHLYVIGGRNET-GYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHN 470
Query: 127 GMVYALGGM-GPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQG 185
G +Y GG+ + P + Y+P D W M T + + +++Y +GG
Sbjct: 471 GKIYISGGVHNGEYVP--WLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHL 528
Query: 186 K----LPVTAFEAFDLEARTWT--RHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFY 239
K L V E +D + W + P L R GCA+ + S++ +GG +
Sbjct: 529 KGFSHLDVMLVECYDPKGDQWNILQTPILEGRSG-PGCAVLDDSIYLVGGYS-------W 580
Query: 240 SRPHFVNTVEMFDLEHGSWTKL 261
S + ++ + E G+WT+L
Sbjct: 581 SMGAYKSSTICYCPEKGTWTEL 602
Score = 65.9 bits (159), Expect = 5e-11
Identities = 44/155 (28%), Positives = 69/155 (44%), Gaps = 8/155 (5%)
Query: 186 KLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFV 245
+LP + +D E +TW +P A E +F LGG Q P+ H
Sbjct: 336 RLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNG----KHST 391
Query: 246 NTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLA 305
N V +D SW +LP M+++RA F L H+ IGG N+ L SVE ++L
Sbjct: 392 NFVSRYDPRFNSWIQLPP---MQERRASFYACRLDKHLYVIGGR-NETGYLSSVECYNLE 447
Query: 306 RRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQG 340
W + ++P + + ++++ GGV G
Sbjct: 448 TNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNG 482
Score = 55.5 bits (132), Expect = 7e-08
Identities = 53/235 (22%), Positives = 89/235 (37%), Gaps = 12/235 (5%)
Query: 33 LLVLGGC--GRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEV 90
LL++GG G LP + + D TW L +P A V + + V+GG D+
Sbjct: 324 LLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQW 383
Query: 91 ----QSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVR 146
+ V + W + + + D +Y +GG +T + V
Sbjct: 384 NPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRN-ETGYLSSVE 442
Query: 147 VYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHP 206
Y + W + S+P P + +H KIY+ GG V +D W R
Sbjct: 443 CYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQ 502
Query: 207 SLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKL 261
+ ++RA A+ ++++GG G + V VE +D + W L
Sbjct: 503 DMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHL-----DVMLVECYDPKGDQWNIL 552
Score = 45.4 bits (106), Expect = 8e-05
Identities = 48/180 (26%), Positives = 75/180 (41%), Gaps = 12/180 (6%)
Query: 10 AWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTAR 69
+W PPM R D HL V+GG G L + E ++ ++ W ++ LP
Sbjct: 403 SWIQLPPMQERRASFYACRLDKHLYVIGGRNETGY-LSSVECYNLETNEWRYVSSLPQPL 461
Query: 70 AGAAAVVLGKQVLVVGGVDEVQ-SPVAAVEAFLMDEGRWERRATL-PQAAMGVATVERDG 127
A A V ++ + GGV + P +MD W R+ + + A+ V D
Sbjct: 462 AAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDV--WARKQDMNTKRAIHTLAVMND- 518
Query: 128 MVYALGG---MGPDTAPQAQVRVYEPRRDCW--LSLPSMPTPCYGASTFLHGNKIYVLGG 182
+YA+GG G V Y+P+ D W L P + G + + IY++GG
Sbjct: 519 RLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRS-GPGCAVLDDSIYLVGG 577
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 73.9 bits (180), Expect = 2e-13
Identities = 60/206 (29%), Positives = 89/206 (43%), Gaps = 12/206 (5%)
Query: 17 MPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVV 76
+P CR V DG + LGG G AG +D E D ++ W A+APLP A AAA V
Sbjct: 671 VPRCRHNSLV--YDGKIYTLGGLGVAG-NVDHVERYDTITNQWEAVAPLPKAVHSAAATV 727
Query: 77 LGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMG 136
G ++ V GGV+E +++++ W + V +G V+ LGG
Sbjct: 728 CGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG-- 785
Query: 137 PDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGG---RQGKLPVTAFE 193
A +Y+P + + P+M S + KIY GG +G + E
Sbjct: 786 ---AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGP-ALGNME 841
Query: 194 AFDLEARTWTRHPSLPSRRAFAGCAM 219
A++ TWT P +P GC +
Sbjct: 842 AYEPTTNTWTLLPHMPCPVFRHGCVV 867
Score = 65.9 bits (159), Expect = 5e-11
Identities = 67/268 (25%), Positives = 109/268 (40%), Gaps = 29/268 (10%)
Query: 56 SHTWLALAPLPTA-RAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAF----LMDEGRWERR 110
++ W LA LP R + V G + + GG++ S V + + L+D R
Sbjct: 612 NNKWYPLASLPFYDREFFSVVSAGDNIYLSGGME---SGVTLADVWCYMSLLDNWNLVSR 668
Query: 111 ATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGAST 170
T+P+ ++ DG +Y LGG+G V Y+ + W ++ +P + A+
Sbjct: 669 MTVPRCRHN--SLVYDGKIYTLGGLGV-AGNVDHVERYDTITNQWEAVAPLPKAVHSAAA 725
Query: 171 FLHGNKIYVLGG-RQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGG 229
+ G KIYV GG + +++ + TW+ S +A G VF LGG
Sbjct: 726 TVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG 785
Query: 230 LQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGL 289
+ ++D E G+ P R + V L G I A GG+
Sbjct: 786 A-------------YARATTIYDPEKGNIKAGPNMNHSRQFCSAVV---LDGKIYATGGI 829
Query: 290 GNQPCP-LGSVESFSLARRRWEALPAMP 316
+ P LG++E++ W LP MP
Sbjct: 830 VSSEGPALGNMEAYEPTTNTWTLLPHMP 857
Score = 54.7 bits (130), Expect = 1e-07
Identities = 66/283 (23%), Positives = 113/283 (39%), Gaps = 28/283 (9%)
Query: 66 PTARAGAAAVVLGKQVLVVGG---VDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVAT 122
P AG A V++ +VGG V Q + AV + +W A+LP +
Sbjct: 576 PRLSAGVAEVIV-----LVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFS 630
Query: 123 VERDG-MVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLG 181
V G +Y GGM A V Y D W + M P ++ ++ KIY LG
Sbjct: 631 VVSAGDNIYLSGGMESGVT-LADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLG 689
Query: 182 GRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSR 241
G V E +D W LP A + G ++ GG+ + G
Sbjct: 690 GLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAG------- 742
Query: 242 PHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVES 301
++ + + +W+ + S + +K A V +L G + +GG + + E
Sbjct: 743 -RAAGVLQSYVPQTNTWSFI-ESPMIDNKYAPAV--TLNGFVFILGGAYARATTIYDPEK 798
Query: 302 FSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGV--AQGPS 342
++ +A P M +R CS++ +++ GG+ ++GP+
Sbjct: 799 GNI-----KAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPA 836
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 73.9 bits (180), Expect = 2e-13
Identities = 60/206 (29%), Positives = 89/206 (43%), Gaps = 12/206 (5%)
Query: 17 MPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVV 76
+P CR V DG + LGG G AG +D E D ++ W A+APLP A AAA V
Sbjct: 671 VPRCRHNSLV--YDGKIYTLGGLGVAG-NVDHVERYDTITNQWEAVAPLPKAVHSAAATV 727
Query: 77 LGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMG 136
G ++ V GGV+E +++++ W + V +G V+ LGG
Sbjct: 728 CGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG-- 785
Query: 137 PDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGG---RQGKLPVTAFE 193
A +Y+P + + P+M S + KIY GG +G + E
Sbjct: 786 ---AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGP-ALGNME 841
Query: 194 AFDLEARTWTRHPSLPSRRAFAGCAM 219
A++ TWT P +P GC +
Sbjct: 842 AYEPTTNTWTLLPHMPCPVFRHGCVV 867
Score = 65.9 bits (159), Expect = 5e-11
Identities = 67/268 (25%), Positives = 109/268 (40%), Gaps = 29/268 (10%)
Query: 56 SHTWLALAPLPTA-RAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAF----LMDEGRWERR 110
++ W LA LP R + V G + + GG++ S V + + L+D R
Sbjct: 612 NNKWYPLASLPFYDREFFSVVSAGDNIYLSGGME---SGVTLADVWCYMSLLDNWNLVSR 668
Query: 111 ATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGAST 170
T+P+ ++ DG +Y LGG+G V Y+ + W ++ +P + A+
Sbjct: 669 MTVPRCRHN--SLVYDGKIYTLGGLGV-AGNVDHVERYDTITNQWEAVAPLPKAVHSAAA 725
Query: 171 FLHGNKIYVLGG-RQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGG 229
+ G KIYV GG + +++ + TW+ S +A G VF LGG
Sbjct: 726 TVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG 785
Query: 230 LQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGL 289
+ ++D E G+ P R + V L G I A GG+
Sbjct: 786 A-------------YARATTIYDPEKGNIKAGPNMNHSRQFCSAVV---LDGKIYATGGI 829
Query: 290 GNQPCP-LGSVESFSLARRRWEALPAMP 316
+ P LG++E++ W LP MP
Sbjct: 830 VSSEGPALGNMEAYEPTTNTWTLLPHMP 857
Score = 54.7 bits (130), Expect = 1e-07
Identities = 66/283 (23%), Positives = 113/283 (39%), Gaps = 28/283 (9%)
Query: 66 PTARAGAAAVVLGKQVLVVGG---VDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVAT 122
P AG A V++ +VGG V Q + AV + +W A+LP +
Sbjct: 576 PRLSAGVAEVIV-----LVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFS 630
Query: 123 VERDG-MVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLG 181
V G +Y GGM A V Y D W + M P ++ ++ KIY LG
Sbjct: 631 VVSAGDNIYLSGGMESGVT-LADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLG 689
Query: 182 GRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSR 241
G V E +D W LP A + G ++ GG+ + G
Sbjct: 690 GLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAG------- 742
Query: 242 PHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVES 301
++ + + +W+ + S + +K A V +L G + +GG + + E
Sbjct: 743 -RAAGVLQSYVPQTNTWSFI-ESPMIDNKYAPAV--TLNGFVFILGGAYARATTIYDPEK 798
Query: 302 FSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGV--AQGPS 342
++ +A P M +R CS++ +++ GG+ ++GP+
Sbjct: 799 GNI-----KAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPA 836
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 73.2 bits (178), Expect = 3e-13
Identities = 66/269 (24%), Positives = 105/269 (39%), Gaps = 22/269 (8%)
Query: 11 WQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETL----DMASHTWLALAPLP 66
W P+P R + VA G + + GG D A L D W+ +A +
Sbjct: 325 WVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMN 384
Query: 67 TARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERD 126
R + ++ +GG +E +++VE + W A LP+ G A
Sbjct: 385 QRRVDFYLASIEDMLVAIGGRNE-NGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYK 443
Query: 127 GMVYALGGMGPDTAP-QAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQG 185
VY GG P + + Y+ R D W M T S G+ IY +GG
Sbjct: 444 DFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDD 503
Query: 186 ------KLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFY 239
+ V EA+ + WTR L + +G A+ EG ++ LGG +
Sbjct: 504 NIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYS-------W 556
Query: 240 SRPHFVNTVEMFDLEHGSWTK---LPRSL 265
F TV+++D E W++ LP+++
Sbjct: 557 ENTAFSKTVQVYDREADKWSRGVDLPKAI 585
Score = 62.8 bits (151), Expect = 5e-10
Identities = 59/245 (24%), Positives = 100/245 (40%), Gaps = 17/245 (6%)
Query: 52 LDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEG----RW 107
LD S W+ PLP R+ VLG + + GG + A L +W
Sbjct: 318 LDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQW 377
Query: 108 ERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYG 167
+ A++ Q + + M+ A+GG + A + V Y P+ D W + +P YG
Sbjct: 378 IKVASMNQRRVDFYLASIEDMLVAIGGRNENGA-LSSVETYSPKTDSWSYVAGLPRFTYG 436
Query: 168 ASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEART--W-TRHPSLPSRRAFAGCAMAEGSV 224
+ ++ + +Y+ GG ++ + RT W R P +R + C++ + S+
Sbjct: 437 HAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGD-SI 495
Query: 225 FSLGGLQQPGPHNFYSRPHF-VNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHI 283
+S+GG N S F V VE + + WT++ L + V G I
Sbjct: 496 YSIGG----SDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESG---VAVWEGRI 548
Query: 284 VAIGG 288
+GG
Sbjct: 549 YILGG 553
Score = 31.6 bits (70), Expect = 1.1
Identities = 43/198 (21%), Positives = 71/198 (35%), Gaps = 26/198 (13%)
Query: 149 EPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGG-----RQGKLPVTAFEAFDLEARTWT 203
+ + + W+ +P + G I++ GG G +D + W
Sbjct: 319 DAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWI 378
Query: 204 RHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPR 263
+ S+ RR A E + ++GG + G +++VE + + SW+ +
Sbjct: 379 KVASMNQRRVDFYLASIEDMLVAIGGRNENGA---------LSSVETYSPKTDSWSYVAG 429
Query: 264 SLRMRDKRA-----DFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTA 318
R A DFV S GGH IG ++ + WE M TA
Sbjct: 430 LPRFTYGHAGTIYKDFVYIS-GGHDYQIGPYRK------NLLCYDHRTDVWEERRPMTTA 482
Query: 319 RCSCSSLQAGPRLFVIGG 336
R S G ++ IGG
Sbjct: 483 RGWHSMCSLGDSIYSIGG 500
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,349,050
Number of Sequences: 37866
Number of extensions: 728884
Number of successful extensions: 2480
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 1553
Number of HSP's gapped (non-prelim): 337
length of query: 354
length of database: 18,247,518
effective HSP length: 103
effective length of query: 251
effective length of database: 14,347,320
effective search space: 3601177320
effective search space used: 3601177320
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.