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Search of human proteins with 254028242
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
(808 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 1640 0.0
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 1556 0.0
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 1013 0.0
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 1005 0.0
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 962 0.0
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 962 0.0
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 957 0.0
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 952 0.0
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 949 0.0
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 926 0.0
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 926 0.0
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 923 0.0
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 922 0.0
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 885 0.0
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 885 0.0
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 857 0.0
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 852 0.0
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 786 0.0
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 681 0.0
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 640 0.0
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 328 2e-89
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 328 2e-89
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 324 2e-88
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 312 7e-85
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 287 3e-77
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 287 3e-77
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur... 277 3e-74
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur... 273 5e-73
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 249 6e-66
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 249 6e-66
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 1640 bits (4246), Expect = 0.0
Identities = 808/808 (100%), Positives = 808/808 (100%)
Query: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
Sbjct: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
Query: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
Sbjct: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
Query: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
Sbjct: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
Query: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
Sbjct: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
Query: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Sbjct: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Query: 301 DGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRA 360
DGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRA
Sbjct: 301 DGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRA 360
Query: 361 AEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFP 420
AEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFP
Sbjct: 361 AEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFP 420
Query: 421 LKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPL 480
LKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPL
Sbjct: 421 LKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPL 480
Query: 481 GEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI 540
GEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI
Sbjct: 481 GEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI 540
Query: 541 INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCA 600
INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCA
Sbjct: 541 INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCA 600
Query: 601 YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV 660
YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV
Sbjct: 601 YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV 660
Query: 661 KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN 720
KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN
Sbjct: 661 KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN 720
Query: 721 CTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTP 780
CTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTP
Sbjct: 721 CTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTP 780
Query: 781 SSSSSGDDSVFAHDLLPPAPPSSGGSRT 808
SSSSSGDDSVFAHDLLPPAPPSSGGSRT
Sbjct: 781 SSSSSGDDSVFAHDLLPPAPPSSGGSRT 808
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 1556 bits (4030), Expect = 0.0
Identities = 774/809 (95%), Positives = 783/809 (96%), Gaps = 4/809 (0%)
Query: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
Sbjct: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
Query: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
Sbjct: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
Query: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
Sbjct: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
Query: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
Sbjct: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
Query: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Sbjct: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Query: 301 DGTPYVTVLKSWISESVEADVR-LRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPR 359
DGTPYVTVLK+ + + + ++ L L NV+ D GEY C A N IG + + WL V
Sbjct: 301 DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVV---L 357
Query: 360 AAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRF 419
AEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRF
Sbjct: 358 PAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRF 417
Query: 420 PLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKP 479
PLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKP
Sbjct: 418 PLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKP 477
Query: 480 LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 539
LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN
Sbjct: 478 LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 537
Query: 540 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSC 599
IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSC
Sbjct: 538 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSC 597
Query: 600 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP 659
AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP
Sbjct: 598 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP 657
Query: 660 VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 719
VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA
Sbjct: 658 VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 717
Query: 720 NCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDT 779
NCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDT
Sbjct: 718 NCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDT 777
Query: 780 PSSSSSGDDSVFAHDLLPPAPPSSGGSRT 808
PSSSSSGDDSVFAHDLLPPAPPSSGGSRT
Sbjct: 778 PSSSSSGDDSVFAHDLLPPAPPSSGGSRT 806
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 1013 bits (2618), Expect = 0.0
Identities = 517/771 (67%), Positives = 605/771 (78%), Gaps = 23/771 (2%)
Query: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Query: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
Query: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
Query: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCR 339
DAQPHIQW+KHVE NGSK GPDG PY+ VLK S A+V L L NV+E D GEY+C+
Sbjct: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEV-LALFNVTEADAGEYICK 341
Query: 340 ATNFIGVAEKAFWLSVHGPRAA---EEELVEADEAGSVYAGILSYGVGFFLFILVVAAVT 396
+N+IG A ++ WL+V + A E+E+ + + Y I Y +G FL +V V
Sbjct: 342 VSNYIGQANQSAWLTVLPKQQAPGREKEITASPD----YLEIAIYCIGVFLIACMVVTVI 397
Query: 397 LCRLRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMSSNTPLVRIA-RLSS-GE 449
LCR+++ KK P VHK++ R PL+RQV S ES++SM+SNTPLVRI RLSS +
Sbjct: 398 LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTAD 457
Query: 450 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV 509
P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAV
Sbjct: 458 TPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAV 517
Query: 510 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 569
KMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+L
Sbjct: 518 KMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL 577
Query: 570 RARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE 629
RARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE
Sbjct: 578 RARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE 637
Query: 630 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 689
+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEI
Sbjct: 638 NNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI 697
Query: 690 FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVED 749
FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPTFKQLVED
Sbjct: 698 FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 757
Query: 750 LDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 800
LDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 758 LDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 808
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 1005 bits (2599), Expect = 0.0
Identities = 511/769 (66%), Positives = 600/769 (78%), Gaps = 20/769 (2%)
Query: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Query: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
Query: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
Query: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVR-LRLANVSERDGGEYLC 338
DAQPHIQW+KHVE NGSK GPDG PY+ VLK+ + + ++ L + NV+ D GEY C
Sbjct: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTC 342
Query: 339 RATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLC 398
A N IG++ + WL+V E+E+ + + Y I Y +G FL +V V LC
Sbjct: 343 LAGNSIGISFHSAWLTVLPAPGREKEITASPD----YLEIAIYCIGVFLIACMVVTVILC 398
Query: 399 RLRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMSSNTPLVRIA-RLSS-GEGP 451
R+++ KK P VHK++ R PL+RQV S ES++SM+SNTPLVRI RLSS + P
Sbjct: 399 RMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTP 458
Query: 452 TLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKM 511
LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAVKM
Sbjct: 459 MLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKM 518
Query: 512 LKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRA 571
LKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+LRA
Sbjct: 519 LKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRA 578
Query: 572 RRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDN 631
RRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE+N
Sbjct: 579 RRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN 638
Query: 632 VMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFT 691
VMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEIFT
Sbjct: 639 VMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 698
Query: 692 LGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLD 751
LGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPTFKQLVEDLD
Sbjct: 699 LGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 758
Query: 752 RVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 800
R+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 759 RILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 807
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 962 bits (2488), Expect = 0.0
Identities = 490/731 (67%), Positives = 576/731 (78%), Gaps = 23/731 (3%)
Query: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Query: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
Query: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
Query: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCR 339
DAQPHIQW+KHVE NGSK GPDG PY+ VLK S A+V L L NV+E D GEY+C+
Sbjct: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEV-LALFNVTEADAGEYICK 341
Query: 340 ATNFIGVAEKAFWLSVHGPRAA---EEELVEADEAGSVYAGILSYGVGFFLFILVVAAVT 396
+N+IG A ++ WL+V + A E+E+ + + Y I Y +G FL +V V
Sbjct: 342 VSNYIGQANQSAWLTVLPKQQAPGREKEITASPD----YLEIAIYCIGVFLIACMVVTVI 397
Query: 397 LCRLRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMSSNTPLVRIA-RLSS-GE 449
LCR+++ KK P VHK++ R PL+RQV S ES++SM+SNTPLVRI RLSS +
Sbjct: 398 LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTAD 457
Query: 450 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV 509
P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAV
Sbjct: 458 TPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAV 517
Query: 510 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 569
KMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+L
Sbjct: 518 KMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL 577
Query: 570 RARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE 629
RARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE
Sbjct: 578 RARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE 637
Query: 630 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 689
+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEI
Sbjct: 638 NNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI 697
Query: 690 FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVED 749
FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPTFKQLVED
Sbjct: 698 FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 757
Query: 750 LDRVLTVTSTD 760
LDR+LT+T+ +
Sbjct: 758 LDRILTLTTNE 768
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 962 bits (2487), Expect = 0.0
Identities = 476/666 (71%), Positives = 553/666 (83%), Gaps = 11/666 (1%)
Query: 142 EDTGVDT-GAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHR 200
EDT ++ GAPYWT E+M+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHR
Sbjct: 29 EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
Query: 201 IGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLP 260
IGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLP
Sbjct: 89 IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLP 148
Query: 261 ANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEAD 320
AN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG PY+ VLK+ + + +
Sbjct: 149 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKE 208
Query: 321 VR-LRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGIL 379
+ L + NV+ D GEY C A N IG++ + WL+V E+E+ + + Y I
Sbjct: 209 IEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPD----YLEIA 264
Query: 380 SYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-RFPLKRQVSLESNASMSSN 436
Y +G FL +V V LCR+++ KK P VHK++ R PL+RQVS ES++SM+SN
Sbjct: 265 IYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSN 324
Query: 437 TPLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAI 494
TPLVRI RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+
Sbjct: 325 TPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAV 384
Query: 495 GIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLY 554
GIDKD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLY
Sbjct: 385 GIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLY 444
Query: 555 VLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQK 614
V+VEYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQK
Sbjct: 445 VIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQK 504
Query: 615 CIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYT 674
CIHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYT
Sbjct: 505 CIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYT 564
Query: 675 HQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWH 734
HQSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWH
Sbjct: 565 HQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWH 624
Query: 735 AAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHD 794
A PSQRPTFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D
Sbjct: 625 AVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPD 684
Query: 795 LLPPAP 800
+P P
Sbjct: 685 PMPYEP 690
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 957 bits (2474), Expect = 0.0
Identities = 476/668 (71%), Positives = 553/668 (82%), Gaps = 13/668 (1%)
Query: 142 EDTGVDT-GAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHR 200
EDT ++ GAPYWT E+M+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHR
Sbjct: 29 EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
Query: 201 IGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLP 260
IGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLP
Sbjct: 89 IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLP 148
Query: 261 ANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEAD 320
AN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG PY+ VLK+ + + +
Sbjct: 149 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKE 208
Query: 321 VR-LRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGIL 379
+ L + NV+ D GEY C A N IG++ + WL+V E+E+ + + Y I
Sbjct: 209 IEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPD----YLEIA 264
Query: 380 SYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMS 434
Y +G FL +V V LCR+++ KK P VHK++ R PL+RQV S ES++SM+
Sbjct: 265 IYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMN 324
Query: 435 SNTPLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAE 492
SNTPLVRI RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAE
Sbjct: 325 SNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAE 384
Query: 493 AIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGP 552
A+GIDKD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GP
Sbjct: 385 AVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGP 444
Query: 553 LYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLAS 612
LYV+VEYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLAS
Sbjct: 445 LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS 504
Query: 613 QKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRV 672
QKCIHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRV
Sbjct: 505 QKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRV 564
Query: 673 YTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMREC 732
YTHQSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+C
Sbjct: 565 YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDC 624
Query: 733 WHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFA 792
WHA PSQRPTFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+
Sbjct: 625 WHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFS 684
Query: 793 HDLLPPAP 800
D +P P
Sbjct: 685 PDPMPYEP 692
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 952 bits (2462), Expect = 0.0
Identities = 485/777 (62%), Positives = 592/777 (76%), Gaps = 21/777 (2%)
Query: 39 PGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLN 98
P P + E + GD ++L C + W++DG L S R + + ++V +
Sbjct: 33 PWGAPVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESNRTRITGEEVEVQD 90
Query: 99 ASHEDSGAYSC-RQRLTQRVLCHFSVRVTDA-PSSGDDEDGED------EAEDTGVDTGA 150
+ DSG Y+C + +FSV V+DA PSS DD+D +D E ++T + A
Sbjct: 91 SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVA 150
Query: 151 PYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQ 210
PYWT PE+M+KKL AVPAA TV+F+CP++G P P++ WLKNG+EF+ +HRIGG K+R+
Sbjct: 151 PYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT 210
Query: 211 WSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSD 270
WS++M+SVVPSD+GNYTC+VEN++GSI TY LDV+ERSPHRPILQAGLPAN+T LGS+
Sbjct: 211 WSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSN 270
Query: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVR-LRLANVS 329
VEF CKVYSD QPHIQWLKH+EVNGSK+GPD PYV +LK+ + + ++ L L NVS
Sbjct: 271 VEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVS 330
Query: 330 ERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFI 389
D GEY C A N IG++ + WL+V A EE A +Y I+ Y G FL
Sbjct: 331 FEDAGEYTCLAGNSIGLSHHSAWLTVL--EALEER--PAVMTSPLYLEIIIYCTGAFLIS 386
Query: 390 LVVAAVTLCRLRSPPKKG--LGSPTVHKISR-FPLKRQV--SLESNASMSSNTPLVRIAR 444
+V +V + +++S KK VHK+++ PL+RQV S +S+ASM+S LVR +R
Sbjct: 387 CMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSR 446
Query: 445 LSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKP 504
LSS P LA VSE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAIG+DKD+ +
Sbjct: 447 LSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 506
Query: 505 VTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGN 564
VAVKMLK DAT+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGN
Sbjct: 507 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 566
Query: 565 LREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARN 624
LRE+L+ARRPPGL+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+KCIHRDLAARN
Sbjct: 567 LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARN 626
Query: 625 VLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 684
VLVTEDNVMKIADFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGV
Sbjct: 627 VLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGV 686
Query: 685 LLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFK 744
LLWEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCT++LYM+MR+CWHA PSQRPTFK
Sbjct: 687 LLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFK 746
Query: 745 QLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAHDLLPPAP 800
QLVEDLDR++ +TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H+ LP P
Sbjct: 747 QLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP 803
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 949 bits (2452), Expect = 0.0
Identities = 481/779 (61%), Positives = 589/779 (75%), Gaps = 23/779 (2%)
Query: 39 PGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLN 98
P P + E + GD ++L C + W++DG L S R + + ++V +
Sbjct: 33 PWGAPVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESNRTRITGEEVEVQD 90
Query: 99 ASHEDSGAYSC-RQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG-------- 149
+ DSG Y+C + +FSV V+DA S +D+D +D++ +T
Sbjct: 91 SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMP 150
Query: 150 -APYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRH 208
APYWT PE+M+KKL AVPAA TV+F+CP++G P P++ WLKNG+EF+ +HRIGG K+R+
Sbjct: 151 VAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY 210
Query: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLG 268
WS++M+SVVPSD+GNYTC+VEN++GSI TY LDV+ERSPHRPILQAGLPAN+T LG
Sbjct: 211 ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG 270
Query: 269 SDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVR-LRLAN 327
S+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD PYV +LK+ + + ++ L L N
Sbjct: 271 SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 330
Query: 328 VSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFL 387
VS D GEY C A N IG++ + WL+V A EE A +Y I+ Y G FL
Sbjct: 331 VSFEDAGEYTCLAGNSIGLSHHSAWLTVL--EALEER--PAVMTSPLYLEIIIYCTGAFL 386
Query: 388 FILVVAAVTLCRLRSPPKKG--LGSPTVHKISR-FPLKRQV--SLESNASMSSNTPLVRI 442
+V +V + +++S KK VHK+++ PL+RQV S +S+ASM+S LVR
Sbjct: 387 ISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRP 446
Query: 443 ARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAA 502
+RLSS P LA VSE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAIG+DKD+
Sbjct: 447 SRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPN 506
Query: 503 KPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK 562
+ VAVKMLK DAT+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+K
Sbjct: 507 RVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 566
Query: 563 GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAA 622
GNLRE+L+ARRPPGL+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+KCIHRDLAA
Sbjct: 567 GNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAA 626
Query: 623 RNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 682
RNVLVTEDNVMKIADFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSF
Sbjct: 627 RNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSF 686
Query: 683 GVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT 742
GVLLWEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCT++LYM+MR+CWHA PSQRPT
Sbjct: 687 GVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPT 746
Query: 743 FKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAHDLLPPAP 800
FKQLVEDLDR++ +TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H+ LP P
Sbjct: 747 FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP 805
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 926 bits (2394), Expect = 0.0
Identities = 464/648 (71%), Positives = 537/648 (82%), Gaps = 19/648 (2%)
Query: 127 DAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
DA SSGDDED D AED + APYWT E+M+K+L AVPAANTV+FRCPA GNP
Sbjct: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
Query: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY
Sbjct: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
Query: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG
Sbjct: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
Query: 303 TPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAA- 361
PY+ VLK S A+V L L NV+E D GEY+C+ +N+IG A ++ WL+V + A
Sbjct: 217 LPYLKVLKHSGINSSNAEV-LALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAP 275
Query: 362 --EEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS 417
E+E+ + + Y I Y +G FL +V V LCR+++ KK P VHK++
Sbjct: 276 GREKEITASPD----YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT 331
Query: 418 -RFPLKRQV--SLESNASMSSNTPLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRA 472
R PL+RQV S ES++SM+SNTPLVRI RLSS + P LA VSE ELP DPKWE R
Sbjct: 332 KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 391
Query: 473 RLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMK 532
+LTLGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMK
Sbjct: 392 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 451
Query: 533 MIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLT 592
MIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+LRARRPPG++YS+D + PEEQ+T
Sbjct: 452 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 511
Query: 593 FKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK 652
FKDLVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKK
Sbjct: 512 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 571
Query: 653 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEG 712
TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEG
Sbjct: 572 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 631
Query: 713 HRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTD 760
HRMDKPANCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR+LT+T+ +
Sbjct: 632 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 679
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 926 bits (2392), Expect = 0.0
Identities = 460/685 (67%), Positives = 550/685 (80%), Gaps = 17/685 (2%)
Query: 129 PSSGDDEDGED------EAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
PSS DD+D +D E ++T + APYWT PE+M+KKL AVPAA TV+F+CP++G P
Sbjct: 34 PSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 93
Query: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI TY
Sbjct: 94 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 153
Query: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD
Sbjct: 154 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 213
Query: 303 TPYVTVLKSWISESVEADVR-LRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAA 361
PYV +LK+ + + ++ L L NVS D GEY C A N IG++ + WL+V A
Sbjct: 214 LPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL--EAL 271
Query: 362 EEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKISR- 418
EE A +Y I+ Y G FL +V +V + +++S KK VHK+++
Sbjct: 272 EER--PAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS 329
Query: 419 FPLKRQV--SLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTL 476
PL+RQV S +S+ASM+S LVR +RLSS P LA VSE ELP DP+WEL R RL L
Sbjct: 330 IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL 389
Query: 477 GKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGK 536
GKPLGEGCFGQVV+AEAIG+DKD+ + VAVKMLK DAT+KDLSDL+SEMEMMKMIGK
Sbjct: 390 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 449
Query: 537 HKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDL 596
HKNIINLLGACTQ GPLYV+VEYA+KGNLRE+L+ARRPPGL+Y ++ PEEQL+ KDL
Sbjct: 450 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 509
Query: 597 VSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNG 656
VSCAYQVARGMEYLAS+KCIHRDLAARNVLVTEDNVMKIADFGLARD+H++DYYKKTTNG
Sbjct: 510 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 569
Query: 657 RLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMD 716
RLPVKWMAPEALFDR+YTHQSDVWSFGVLLWEIFTLGGSPYPG+PVEELFKLLKEGHRMD
Sbjct: 570 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD 629
Query: 717 KPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGG 776
KP+NCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR++ +TS EYLDLS P +QYSP
Sbjct: 630 KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF 689
Query: 777 QDTPSSS-SSGDDSVFAHDLLPPAP 800
DT SS+ SSG+DSVF+H+ LP P
Sbjct: 690 PDTRSSTCSSGEDSVFSHEPLPEEP 714
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 923 bits (2386), Expect = 0.0
Identities = 461/660 (69%), Positives = 538/660 (81%), Gaps = 16/660 (2%)
Query: 127 DAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
DA SSGDDED D AED + APYWT E+M+K+L AVPAANTV+FRCPA GNP
Sbjct: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
Query: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY
Sbjct: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
Query: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG
Sbjct: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
Query: 303 TPYVTVLKSWISESVEADVR-LRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAA 361
PY+ VLK+ + + ++ L + NV+ D GEY C A N IG++ + WL+V
Sbjct: 217 LPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGR 276
Query: 362 EEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-R 418
E+E+ + + Y I Y +G FL +V V LCR+++ KK P VHK++ R
Sbjct: 277 EKEITASPD----YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKR 332
Query: 419 FPLKRQV--SLESNASMSSNTPLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARL 474
PL+RQV S ES++SM+SNTPLVRI RLSS + P LA VSE ELP DPKWE R +L
Sbjct: 333 IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL 392
Query: 475 TLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMI 534
TLGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMI
Sbjct: 393 TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI 452
Query: 535 GKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFK 594
GKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFK
Sbjct: 453 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK 512
Query: 595 DLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTT 654
DLVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTT
Sbjct: 513 DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT 572
Query: 655 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHR 714
NGRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHR
Sbjct: 573 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR 632
Query: 715 MDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSP 774
MDKPANCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR+LT+T+ +E +S + + P
Sbjct: 633 MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEEKKVSGAVDCHKP 692
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 922 bits (2382), Expect = 0.0
Identities = 460/687 (66%), Positives = 549/687 (79%), Gaps = 19/687 (2%)
Query: 129 PSSGDDEDGEDEA-EDTGVDTG-------APYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
PSS DD+D +D + E+ D APYWT PE+M+KKL AVPAA TV+F+CP++G
Sbjct: 34 PSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG 93
Query: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
P P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI T
Sbjct: 94 TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHT 153
Query: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Y LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GP
Sbjct: 154 YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 213
Query: 301 DGTPYVTVLKSWISESVEADVR-LRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPR 359
D PYV +LK+ + + ++ L L NVS D GEY C A N IG++ + WL+V
Sbjct: 214 DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL--E 271
Query: 360 AAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS 417
A EE A +Y I+ Y G FL +V +V + +++S KK VHK++
Sbjct: 272 ALEER--PAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLA 329
Query: 418 R-FPLKRQV--SLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARL 474
+ PL+RQV S +S+ASM+S LVR +RLSS P LA VSE ELP DP+WEL R RL
Sbjct: 330 KSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRL 389
Query: 475 TLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMI 534
LGKPLGEGCFGQVV+AEAIG+DKD+ + VAVKMLK DAT+KDLSDL+SEMEMMKMI
Sbjct: 390 VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMI 449
Query: 535 GKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFK 594
GKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+L+ARRPPGL+Y ++ PEEQL+ K
Sbjct: 450 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSK 509
Query: 595 DLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTT 654
DLVSCAYQVARGMEYLAS+KCIHRDLAARNVLVTEDNVMKIADFGLARD+H++DYYKKTT
Sbjct: 510 DLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTT 569
Query: 655 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHR 714
NGRLPVKWMAPEALFDR+YTHQSDVWSFGVLLWEIFTLGGSPYPG+PVEELFKLLKEGHR
Sbjct: 570 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHR 629
Query: 715 MDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSP 774
MDKP+NCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR++ +TS EYLDLS P +QYSP
Sbjct: 630 MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSP 689
Query: 775 GGQDTPSSS-SSGDDSVFAHDLLPPAP 800
DT SS+ SSG+DSVF+H+ LP P
Sbjct: 690 SFPDTRSSTCSSGEDSVFSHEPLPEEP 716
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 885 bits (2287), Expect = 0.0
Identities = 484/795 (60%), Positives = 561/795 (70%), Gaps = 16/795 (2%)
Query: 8 LALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGG 67
LAL + V G SL + V P E Q+++L G V L C G
Sbjct: 5 LALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQ-QEQELTVALGQPVRLCCGRAERG 63
Query: 68 PMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTD 127
W K+G+ L P+ RV RL++ + ED+G Y C R + VL + ++ D
Sbjct: 64 GH----WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGD 119
Query: 128 A-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPT 183
+ SS DDED + D + APYWT P+RM+KKL AVPA NTV+FRCPAAGNPT
Sbjct: 120 SLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPT 179
Query: 184 PSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 243
P+I WLK+G+ F GE+RIGGI+LRHQ WSLVMESVVPSDRG YTC+VEN GSIR Y L
Sbjct: 180 PTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLL 239
Query: 244 DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 303
DVLERSPHRPILQAGLPAN TAV+GSDVE CKVYSDAQPHIQWLKH+ +NGS G DG
Sbjct: 240 DVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299
Query: 304 PYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEE 363
PYV VLK+ S E +V L L NVS D GEY C A N IG++ ++ WL+V P
Sbjct: 300 PYVQVLKTADINSSEVEV-LYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVL-PEEDPT 357
Query: 364 ELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSP-TVHKISRFPLK 422
A EA Y I+ Y G +++ L R ++ + P TV K+SRFPL
Sbjct: 358 WTAAAPEAR--YTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLA 415
Query: 423 RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE 482
RQ SLES +S S++ LVR RLSS LA + L+LP DP WE R RL LGKPLGE
Sbjct: 416 RQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGE 475
Query: 483 GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN 542
GCFGQVV AEA G+D R + TVAVKMLKD+A+DKDL+DLVSEME+MK+IG+HKNIIN
Sbjct: 476 GCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIIN 535
Query: 543 LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ 602
LLG CTQ GPLYV+VE AAKGNLREFLRARRPPG D S D + E L+F LVSCAYQ
Sbjct: 536 LLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQ 595
Query: 603 VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW 662
VARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR VH++DYYKKT+NGRLPVKW
Sbjct: 596 VARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKW 655
Query: 663 MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT 722
MAPEALFDRVYTHQSDVWSFG+LLWEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C
Sbjct: 656 MAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCP 715
Query: 723 HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS 782
+LY +MRECWHAAPSQRPTFKQLVE LD+VL S +EYLDL F YSP G D SS
Sbjct: 716 PELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS-EEYLDLRLTFGPYSPSGGDA-SS 773
Query: 783 SSSGDDSVFAHDLLP 797
+ S DSVF+HD LP
Sbjct: 774 TCSSSDSVFSHDPLP 788
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 885 bits (2287), Expect = 0.0
Identities = 484/795 (60%), Positives = 561/795 (70%), Gaps = 16/795 (2%)
Query: 8 LALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGG 67
LAL + V G SL + V P E Q+++L G V L C G
Sbjct: 5 LALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQ-QEQELTVALGQPVRLCCGRAERG 63
Query: 68 PMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTD 127
W K+G+ L P+ RV RL++ + ED+G Y C R + VL + ++ D
Sbjct: 64 GH----WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGD 119
Query: 128 A-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPT 183
+ SS DDED + D + APYWT P+RM+KKL AVPA NTV+FRCPAAGNPT
Sbjct: 120 SLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPT 179
Query: 184 PSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 243
P+I WLK+G+ F GE+RIGGI+LRHQ WSLVMESVVPSDRG YTC+VEN GSIR Y L
Sbjct: 180 PTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLL 239
Query: 244 DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 303
DVLERSPHRPILQAGLPAN TAV+GSDVE CKVYSDAQPHIQWLKH+ +NGS G DG
Sbjct: 240 DVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299
Query: 304 PYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEE 363
PYV VLK+ S E +V L L NVS D GEY C A N IG++ ++ WL+V P
Sbjct: 300 PYVQVLKTADINSSEVEV-LYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVL-PEEDPT 357
Query: 364 ELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSP-TVHKISRFPLK 422
A EA Y I+ Y G +++ L R ++ + P TV K+SRFPL
Sbjct: 358 WTAAAPEAR--YTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLA 415
Query: 423 RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE 482
RQ SLES +S S++ LVR RLSS LA + L+LP DP WE R RL LGKPLGE
Sbjct: 416 RQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGE 475
Query: 483 GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN 542
GCFGQVV AEA G+D R + TVAVKMLKD+A+DKDL+DLVSEME+MK+IG+HKNIIN
Sbjct: 476 GCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIIN 535
Query: 543 LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ 602
LLG CTQ GPLYV+VE AAKGNLREFLRARRPPG D S D + E L+F LVSCAYQ
Sbjct: 536 LLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQ 595
Query: 603 VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW 662
VARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR VH++DYYKKT+NGRLPVKW
Sbjct: 596 VARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKW 655
Query: 663 MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT 722
MAPEALFDRVYTHQSDVWSFG+LLWEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C
Sbjct: 656 MAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCP 715
Query: 723 HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS 782
+LY +MRECWHAAPSQRPTFKQLVE LD+VL S +EYLDL F YSP G D SS
Sbjct: 716 PELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS-EEYLDLRLTFGPYSPSGGDA-SS 773
Query: 783 SSSGDDSVFAHDLLP 797
+ S DSVF+HD LP
Sbjct: 774 TCSSSDSVFSHDPLP 788
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 857 bits (2215), Expect = 0.0
Identities = 450/779 (57%), Positives = 553/779 (70%), Gaps = 60/779 (7%)
Query: 39 PGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLN 98
P P + E + GD ++L C + W++DG L S R + + ++V +
Sbjct: 33 PWGAPVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESNRTRITGEEVEVQD 90
Query: 99 ASHEDSGAYSC-RQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG-------- 149
+ DSG Y+C + +FSV V+DA S +D+D +D++ +T
Sbjct: 91 SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMP 150
Query: 150 -APYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRH 208
APYWT PE+M+KKL AVPAA TV+F+CP++G P P++ WLKNG+EF+ +HRIGG K+R+
Sbjct: 151 VAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY 210
Query: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLG 268
WS++M+SVVPSD+GNYTC+VEN++GSI TY LDV+ERSPHRPILQAGLPAN+T LG
Sbjct: 211 ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG 270
Query: 269 SDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVR-LRLAN 327
S+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD PYV +LK+ + + ++ L L N
Sbjct: 271 SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 330
Query: 328 VSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFL 387
VS D GEY C A N IG++ + WL+V A EE A +Y I+ Y G FL
Sbjct: 331 VSFEDAGEYTCLAGNSIGLSHHSAWLTVL--EALEER--PAVMTSPLYLEIIIYCTGAFL 386
Query: 388 FILVVAAVTLCRLRSPPKKG--LGSPTVHKISR-FPLKRQV--SLESNASMSSNTPLVRI 442
+V +V + +++S KK VHK+++ PL+RQV S +S+ASM+S LVR
Sbjct: 387 ISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRP 446
Query: 443 ARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAA 502
+RLSS P LA VSE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAIG+DKD+
Sbjct: 447 SRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPN 506
Query: 503 KPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK 562
+ VAVKMLK DAT+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+K
Sbjct: 507 RVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 566
Query: 563 GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAA 622
GNLRE+L+ARRPPGL+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+KCIHRDLAA
Sbjct: 567 GNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAA 626
Query: 623 RNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 682
RNVLVTEDNVMKIADFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSF
Sbjct: 627 RNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSF 686
Query: 683 GVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT 742
GVLLWEIFTLGGSPYPG+PVEEL
Sbjct: 687 GVLLWEIFTLGGSPYPGVPVEEL------------------------------------- 709
Query: 743 FKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAHDLLPPAP 800
FKQLVEDLDR++ +TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H+ LP P
Sbjct: 710 FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP 768
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 852 bits (2201), Expect = 0.0
Identities = 469/794 (59%), Positives = 541/794 (68%), Gaps = 54/794 (6%)
Query: 8 LALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGG 67
LAL + V G SL + V P E Q+++L G V L C G
Sbjct: 5 LALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQ-QEQELTVALGQPVRLCCGRAERG 63
Query: 68 PMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTD 127
W K+G+ L P+ RV RL++ + ED+G Y C R + VL + ++ D
Sbjct: 64 GH----WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGD 119
Query: 128 A-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPT 183
+ SS DDED + D + APYWT P+RM+KKL AVPA NTV+FRCPAAGNPT
Sbjct: 120 SLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPT 179
Query: 184 PSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 243
P+I WLK+G+ F GE+RIGGI+LRHQ WSLVMESVVPSDRG YTC+VEN GSIR Y L
Sbjct: 180 PTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLL 239
Query: 244 DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 303
DVLERSPHRPILQAGLPAN TAV+GSDVE CKVYSDAQPHIQWLKH+ +NGS G DG
Sbjct: 240 DVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299
Query: 304 PYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEE 363
PYV VLK+ S E +V L L NVS D GEY C A N IG++ ++ WL+V
Sbjct: 300 PYVQVLKTADINSSEVEV-LYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP------ 352
Query: 364 ELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKR 423
G G + + R +SP
Sbjct: 353 ------------------GTGRIPHLTCDSLTPAGRTKSPTL------------------ 376
Query: 424 QVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEG 483
Q SLES +S S++ LVR RLSS LA + L+LP DP WE R RL LGKPLGEG
Sbjct: 377 QFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEG 436
Query: 484 CFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINL 543
CFGQVV AEA G+D R + TVAVKMLKD+A+DKDL+DLVSEME+MK+IG+HKNIINL
Sbjct: 437 CFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINL 496
Query: 544 LGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQV 603
LG CTQ GPLYV+VE AAKGNLREFLRARRPPG D S D + E L+F LVSCAYQV
Sbjct: 497 LGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQV 556
Query: 604 ARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWM 663
ARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR VH++DYYKKT+NGRLPVKWM
Sbjct: 557 ARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWM 616
Query: 664 APEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTH 723
APEALFDRVYTHQSDVWSFG+LLWEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C
Sbjct: 617 APEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPP 676
Query: 724 DLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSS 783
+LY +MRECWHAAPSQRPTFKQLVE LD+VL S +EYLDL F YSP G D SS+
Sbjct: 677 ELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS-EEYLDLRLTFGPYSPSGGDA-SST 734
Query: 784 SSGDDSVFAHDLLP 797
S DSVF+HD LP
Sbjct: 735 CSSSDSVFSHDPLP 748
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 786 bits (2029), Expect = 0.0
Identities = 418/550 (76%), Positives = 439/550 (79%), Gaps = 39/550 (7%)
Query: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLR------ 324
V F C + P I WLK NG + + E ++LR
Sbjct: 172 VRFRCPAAGNPTPSISWLK----NG--------------REFRGEHRIGGIKLRHQQWSL 213
Query: 325 -LANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGV 383
+ +V D G Y C N G + + L V R+ +++A + A +L V
Sbjct: 214 VMESVVPSDRGNYTCVVENKFGSIRQTYTLDVL-ERSPHRPILQAGLPANQTA-VLGSDV 271
Query: 384 GFFLFILVVAAVTLCRLRSPPKKGL-----GSPTVHKISRFPLKRQVSLESNASMSSNTP 438
F + A + L+ G G+P V + +VSLESNASMSSNTP
Sbjct: 272 EFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVL-------KVSLESNASMSSNTP 324
Query: 439 LVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDK 498
LVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDK
Sbjct: 325 LVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDK 384
Query: 499 DRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVE 558
DRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVE
Sbjct: 385 DRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVE 444
Query: 559 YAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHR 618
YAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHR
Sbjct: 445 YAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHR 504
Query: 619 DLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSD 678
DLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSD
Sbjct: 505 DLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSD 564
Query: 679 VWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPS 738
VWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPS
Sbjct: 565 VWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPS 624
Query: 739 QRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPP 798
QRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPP
Sbjct: 625 QRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPP 684
Query: 799 APPSSGGSRT 808
APPSSGGSRT
Sbjct: 685 APPSSGGSRT 694
Score = 643 bits (1658), Expect = 0.0
Identities = 313/335 (93%), Positives = 317/335 (94%)
Query: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
Sbjct: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
Query: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
Sbjct: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
Query: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
Sbjct: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
Query: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
Sbjct: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
Query: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Sbjct: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Query: 301 DGTPYVTVLKSWISESVEADVRLRLANVSERDGGE 335
DGTPYVTVLK + + L ++ GE
Sbjct: 301 DGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGE 335
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 681 bits (1758), Expect = 0.0
Identities = 357/539 (66%), Positives = 409/539 (75%), Gaps = 27/539 (5%)
Query: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT--PYVTVLKSWISESVEADVRLRLANV 328
V+F C + P ++WLK NG + + Y + W L + +V
Sbjct: 175 VKFRCPAGGNPMPTMRWLK----NGKEFKQEHRIGGYKVRNQHW---------SLIMESV 221
Query: 329 SERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLF 388
D G Y C N G + L V P +E D Y I Y +G FL
Sbjct: 222 VPSDKGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPD-----YLEIAIYCIGVFLI 276
Query: 389 ILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMSSNTPLVRIA 443
+V V LCR+++ KK P VHK++ R PL+RQV S ES++SM+SNTPLVRI
Sbjct: 277 ACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 336
Query: 444 -RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRA 501
RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+
Sbjct: 337 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 396
Query: 502 AKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAA 561
+ VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+
Sbjct: 397 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 456
Query: 562 KGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 621
KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLA
Sbjct: 457 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 516
Query: 622 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 681
ARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS
Sbjct: 517 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 576
Query: 682 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP 741
FGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRP
Sbjct: 577 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 636
Query: 742 TFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 800
TFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 637 TFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 695
Score = 212 bits (540), Expect = 1e-54
Identities = 109/207 (52%), Positives = 138/207 (66%), Gaps = 8/207 (3%)
Query: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Query: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
Query: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVL 246
PSD+GNYTCVVEN++GSI TY LDV+
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVV 249
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 640 bits (1650), Expect = 0.0
Identities = 341/539 (63%), Positives = 399/539 (74%), Gaps = 31/539 (5%)
Query: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT--PYVTVLKSWISESVEADVRLRLANV 328
V+F C + P ++WLK NG + + Y + W L + +V
Sbjct: 175 VKFRCPAGGNPMPTMRWLK----NGKEFKQEHRIGGYKVRNQHW---------SLIMESV 221
Query: 329 SERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLF 388
D G Y C N G + L V R+ +++A + + ++ V F
Sbjct: 222 VPSDKGNYTCVVENEYGSINHTYHLDVV-ERSPHRPILQAGLPANA-STVVGGDVEFVCK 279
Query: 389 ILVVAAVTLCRLRSPPKKGL-----GSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIA 443
+ A + ++ K G G P + + +VS ES++SM+SNTPLVRI
Sbjct: 280 VYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVL-------KVSAESSSSMNSNTPLVRIT 332
Query: 444 -RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRA 501
RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+
Sbjct: 333 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 392
Query: 502 AKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAA 561
+ VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+
Sbjct: 393 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 452
Query: 562 KGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 621
KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLA
Sbjct: 453 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 512
Query: 622 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 681
ARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS
Sbjct: 513 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 572
Query: 682 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP 741
FGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRP
Sbjct: 573 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 632
Query: 742 TFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 800
TFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 633 TFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 691
Score = 323 bits (829), Expect = 3e-88
Identities = 164/292 (56%), Positives = 200/292 (68%), Gaps = 8/292 (2%)
Query: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Query: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
Query: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
Query: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSER 331
DAQPHIQW+KHVE NGSK GPDG PY+ VLK S + L ++ R
Sbjct: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESSSSMNSNTPLVRITTR 334
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 328 bits (840), Expect = 2e-89
Identities = 174/344 (50%), Positives = 226/344 (65%), Gaps = 23/344 (6%)
Query: 455 NVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKD 514
+V ++ DPKWE R L LGK LGEG FG+VV A A + K RA TVAVKMLK+
Sbjct: 705 SVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-KGRAGY-TTVAVKMLKE 762
Query: 515 DATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRP 574
+A+ +L DL+SE ++K + H ++I L GAC+Q GPL ++VEYA G+LR FLR R
Sbjct: 763 NASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK 821
Query: 575 PGLDY--------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVL 626
G Y S P E LT DL+S A+Q+++GM+YLA K +HRDLAARN+L
Sbjct: 822 VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL 881
Query: 627 VTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLL 686
V E MKI+DFGL+RDV+ D Y K + GR+PVKWMA E+LFD +YT QSDVWSFGVLL
Sbjct: 882 VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL 941
Query: 687 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQL 746
WEI TLGG+PYPGIP E LF LLK GHRM++P NC+ ++Y +M +CW P +RP F +
Sbjct: 942 WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 1001
Query: 747 VEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSV 790
+DL++++ +YLDL+A TPS S DD +
Sbjct: 1002 SKDLEKMM--VKRRDYLDLAA----------STPSDSLIYDDGL 1033
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 328 bits (840), Expect = 2e-89
Identities = 174/344 (50%), Positives = 226/344 (65%), Gaps = 23/344 (6%)
Query: 455 NVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKD 514
+V ++ DPKWE R L LGK LGEG FG+VV A A + K RA TVAVKMLK+
Sbjct: 705 SVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-KGRAGY-TTVAVKMLKE 762
Query: 515 DATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRP 574
+A+ +L DL+SE ++K + H ++I L GAC+Q GPL ++VEYA G+LR FLR R
Sbjct: 763 NASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK 821
Query: 575 PGLDY--------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVL 626
G Y S P E LT DL+S A+Q+++GM+YLA K +HRDLAARN+L
Sbjct: 822 VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL 881
Query: 627 VTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLL 686
V E MKI+DFGL+RDV+ D Y K + GR+PVKWMA E+LFD +YT QSDVWSFGVLL
Sbjct: 882 VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL 941
Query: 687 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQL 746
WEI TLGG+PYPGIP E LF LLK GHRM++P NC+ ++Y +M +CW P +RP F +
Sbjct: 942 WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 1001
Query: 747 VEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSV 790
+DL++++ +YLDL+A TPS S DD +
Sbjct: 1002 SKDLEKMM--VKRRDYLDLAA----------STPSDSLIYDDGL 1033
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 324 bits (831), Expect = 2e-88
Identities = 223/624 (35%), Positives = 311/624 (49%), Gaps = 119/624 (19%)
Query: 222 DRGNYTCVVENKFGSIRQTYT--LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
D+G+Y C+ +++ R L VLER P + L NQT +G +E C
Sbjct: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIGESIEVSCTASG 692
Query: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCR 339
+ P I W K E G VLK + + L + V + D G Y C+
Sbjct: 693 NPPPQIMWFKDNETLVEDSG-------IVLK-------DGNRNLTIRRVRKEDEGLYTCQ 738
Query: 340 ATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCR 399
A + +G A+ + + G A E+ +E + G + F+L ++++
Sbjct: 739 ACSVLGCAKVEAFFIIEG--AQEKTNLEI----IILVGTAVIAMFFWLLLVII------- 785
Query: 400 LRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSEL 459
LR+ + G +S ++ L+ +
Sbjct: 786 LRTVKRANGGELKTGYLSIVMDPDELPLDEHCE--------------------------- 818
Query: 460 ELPADP-KWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATD 518
LP D KWE R RL LGKPLG G FGQV+ A+A GIDK + TVAVKMLK+ AT
Sbjct: 819 RLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCR--TVAVKMLKEGATH 876
Query: 519 KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ-GGPLYVLVEYAAKGNLREFLRARRPP-- 575
+ L+SE++++ IG H N++NLLGACT+ GGPL V+VE+ GNL +LR++R
Sbjct: 877 SEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFV 936
Query: 576 -----------GLDY---------------------------------SFDTCKPPEEQ- 590
G DY + + PE+
Sbjct: 937 PYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLY 996
Query: 591 ---LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNL 647
LT + L+ ++QVA+GME+LAS+KCIHRDLAARN+L++E NV+KI DFGLARD++
Sbjct: 997 KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKD 1056
Query: 648 DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELF- 706
Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVLLWEIF+LG SPYPG+ ++E F
Sbjct: 1057 PDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFC 1116
Query: 707 KLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDE----- 761
+ LKEG RM P T ++Y M +CWH PSQRPTF +LVE L +L + +
Sbjct: 1117 RRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYI 1176
Query: 762 YLDLSAPFEQYSPGGQDTPSSSSS 785
L +S G P+S S
Sbjct: 1177 VLPISETLSMEEDSGLSLPTSPVS 1200
Score = 45.8 bits (107), Expect = 2e-04
Identities = 34/133 (25%), Positives = 53/133 (39%), Gaps = 7/133 (5%)
Query: 161 KKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVP 220
+ L+ VR G P P I W KNG H IK H L + V
Sbjct: 337 ESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHT---IKAGH---VLTIMEVSE 390
Query: 221 SDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSD 280
D GNYT ++ N +Q++ + ++ P + ++ + + G+ C VY+
Sbjct: 391 RDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAI 450
Query: 281 AQP-HIQWLKHVE 292
P HI W +E
Sbjct: 451 PPPHHIHWYWQLE 463
Score = 37.7 bits (86), Expect = 0.043
Identities = 33/135 (24%), Positives = 55/135 (40%), Gaps = 24/135 (17%)
Query: 94 LQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW 153
+++ NAS +D G Y C + + H VR + T ++ AP
Sbjct: 627 MELKNASLQDQGDYVCLAQDRKTKKRHCVVR-----------------QLTVLERVAP-- 667
Query: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSL 213
T ++ + ++ ++ C A+GNP P I W K+ + GI L+ +L
Sbjct: 668 TITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNL 722
Query: 214 VMESVVPSDRGNYTC 228
+ V D G YTC
Sbjct: 723 TIRRVRKEDEGLYTC 737
Score = 37.4 bits (85), Expect = 0.056
Identities = 38/160 (23%), Positives = 69/160 (43%), Gaps = 26/160 (16%)
Query: 212 SLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQ--AGLPANQTAVLGS 269
+L ++ V SD+G YTC + + + + + V E+ P + +G+ + A +G
Sbjct: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
Query: 270 DVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVS 329
V K P I+W K+ G P + + +++A L + VS
Sbjct: 347 RVRIPAKYLGYPPPEIKWYKN-----------GIPLES------NHTIKAGHVLTIMEVS 389
Query: 330 ERDGGEYLCRATNFIGVAEKAFWLSV---HGPRAAEEELV 366
ERD G Y TN I +++ +S+ P+ E+ L+
Sbjct: 390 ERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLI 429
Score = 37.0 bits (84), Expect = 0.073
Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 44 GQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLV--GPQRLQVLNASH 101
G E G+++E+SC G P +W KD LV +++ G + L +
Sbjct: 671 GNLENQTTSIGESIEVSCTA-SGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRK 729
Query: 102 EDSGAYSCR 110
ED G Y+C+
Sbjct: 730 EDEGLYTCQ 738
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 312 bits (800), Expect = 7e-85
Identities = 216/632 (34%), Positives = 307/632 (48%), Gaps = 121/632 (19%)
Query: 212 SLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDV 271
+L + +V D G Y C N + ++ R P L L ++ T + S
Sbjct: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISSST 678
Query: 272 EFHCKVYSDAQPHIQWLKH----VEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLAN 327
C +P I W K+ + G +GP + L +
Sbjct: 679 TLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSST------------------LFIER 720
Query: 328 VSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFL 387
V+E D G Y C+ATN G E + +L+V G +D++ + V L
Sbjct: 721 VTEEDEGVYHCKATNQKGSVESSAYLTVQGT---------SDKSNLELITLTCTCVAATL 771
Query: 388 FILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSS 447
F L++ + K+ R +S T + I +
Sbjct: 772 FWLLLTLF-----------------IRKMKR------------SSSEIKTDYLSII-MDP 801
Query: 448 GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTV 507
E P L A KWE +R RL LGK LG G FG+VV A A GI K + TV
Sbjct: 802 DEVPLDEQCERLPYDAS-KWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR--TV 858
Query: 508 AVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QGGPLYVLVEYAAKGNLR 566
AVKMLK+ AT + L++E++++ IG H N++NLLGACT QGGPL V+VEY GNL
Sbjct: 859 AVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLS 918
Query: 567 EFLRARRP--------------------PGL------------------------DYSFD 582
+L+++R PGL D S
Sbjct: 919 NYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLS 978
Query: 583 TCKPPE-------EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKI 635
+ E E +T +DL+S ++QVARGME+L+S+KCIHRDLAARN+L++E+NV+KI
Sbjct: 979 DVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKI 1038
Query: 636 ADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGS 695
DFGLARD++ Y + + RLP+KWMAPE++FD++Y+ +SDVWS+GVLLWEIF+LGGS
Sbjct: 1039 CDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGS 1098
Query: 696 PYPGIPVEELF-KLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVL 754
PYPG+ ++E F L+EG RM P T ++Y IM +CWH P +RP F +LVE L +L
Sbjct: 1099 PYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLL 1158
Query: 755 TVT---STDEYLDLSAPFEQYSPGGQDTPSSS 783
+Y+ ++A S TP+ S
Sbjct: 1159 QANVQQDGKDYIPINAILTGNSGFTYSTPAFS 1190
Score = 54.7 bits (130), Expect = 3e-07
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 24/152 (15%)
Query: 94 LQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW 153
L ++N S +DSG Y+CR R + E+ + E T D APY
Sbjct: 621 LTIMNVSLQDSGTYACRAR-----------------NVYTGEEILQKKEITIRDQEAPYL 663
Query: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSL 213
R + +A+ ++ T+ C A G P P I+W KN + + E GI L +L
Sbjct: 664 LR--NLSDHTVAISSSTTL--DCHANGVPEPQITWFKNNHKIQQE---PGIILGPGSSTL 716
Query: 214 VMESVVPSDRGNYTCVVENKFGSIRQTYTLDV 245
+E V D G Y C N+ GS+ + L V
Sbjct: 717 FIERVTEEDEGVYHCKATNQKGSVESSAYLTV 748
Score = 43.5 bits (101), Expect = 8e-04
Identities = 34/141 (24%), Positives = 57/141 (40%), Gaps = 10/141 (7%)
Query: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSL 213
T R + L V + R P+P + WLK+G + + + +SL
Sbjct: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEK----SARYLTRGYSL 390
Query: 214 VMESVVPSDRGNYTCVV----ENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269
+++ V D GNYT ++ N F ++ T ++V + + + + P LGS
Sbjct: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
Query: 270 DVEFHCKVYSDAQPHIQWLKH 290
C Y QP I+W H
Sbjct: 449 RQILTCTAYGIPQPTIKWFWH 469
Score = 38.1 bits (87), Expect = 0.033
Identities = 29/121 (23%), Positives = 50/121 (41%), Gaps = 13/121 (10%)
Query: 224 GNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQP 283
G Y C+ NK G++ + + + + + +P G D++ C V
Sbjct: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTE-----GEDLKLSCTVNKFLYR 585
Query: 284 HIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLA--NVSERDGGEYLCRAT 341
+ W+ VN T + ++ K ++ + E + L L NVS +D G Y CRA
Sbjct: 586 DVTWILLRTVNNR------TMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRAR 639
Query: 342 N 342
N
Sbjct: 640 N 640
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 287 bits (734), Expect = 3e-77
Identities = 158/378 (41%), Positives = 217/378 (57%), Gaps = 63/378 (16%)
Query: 450 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV 509
G + +LP D KWE R RL+ GK LG G FG+VV A A G+ K AA +TVAV
Sbjct: 561 GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAA--MTVAV 618
Query: 510 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 569
KMLK A + L+SE++++ +G H NI+NLLGACT GGP V+ EY G+L FL
Sbjct: 619 KMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFL 678
Query: 570 RARRP--------------------------------------PGLDYSFDT-------- 583
R +R PG+ Y T
Sbjct: 679 RRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSV 738
Query: 584 --------------CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE 629
+ E L +DL+S +YQVA+GM +LAS+ CIHRDLAARN+L+T
Sbjct: 739 RIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH 798
Query: 630 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 689
+ KI DFGLARD+ N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ LWE+
Sbjct: 799 GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWEL 858
Query: 690 FTLGGSPYPGIPVE-ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE 748
F+LG SPYPG+PV+ + +K++KEG RM P + ++Y IM+ CW A P +RPTFKQ+V+
Sbjct: 859 FSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 918
Query: 749 DLDRVLTVTSTDEYLDLS 766
+++ ++ ++ Y +L+
Sbjct: 919 LIEKQISESTNHIYSNLA 936
Score = 30.8 bits (68), Expect = 5.3
Identities = 14/40 (35%), Positives = 23/40 (57%)
Query: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLER 248
+Q +L + S +D G + C N FGS T TL+V+++
Sbjct: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDK 310
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 287 bits (734), Expect = 3e-77
Identities = 158/378 (41%), Positives = 217/378 (57%), Gaps = 63/378 (16%)
Query: 450 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV 509
G + +LP D KWE R RL+ GK LG G FG+VV A A G+ K AA +TVAV
Sbjct: 565 GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAA--MTVAV 622
Query: 510 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 569
KMLK A + L+SE++++ +G H NI+NLLGACT GGP V+ EY G+L FL
Sbjct: 623 KMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFL 682
Query: 570 RARRP--------------------------------------PGLDYSFDT-------- 583
R +R PG+ Y T
Sbjct: 683 RRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSV 742
Query: 584 --------------CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE 629
+ E L +DL+S +YQVA+GM +LAS+ CIHRDLAARN+L+T
Sbjct: 743 RIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH 802
Query: 630 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 689
+ KI DFGLARD+ N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ LWE+
Sbjct: 803 GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWEL 862
Query: 690 FTLGGSPYPGIPVE-ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE 748
F+LG SPYPG+PV+ + +K++KEG RM P + ++Y IM+ CW A P +RPTFKQ+V+
Sbjct: 863 FSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 922
Query: 749 DLDRVLTVTSTDEYLDLS 766
+++ ++ ++ Y +L+
Sbjct: 923 LIEKQISESTNHIYSNLA 940
Score = 30.8 bits (68), Expect = 5.3
Identities = 14/40 (35%), Positives = 23/40 (57%)
Query: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLER 248
+Q +L + S +D G + C N FGS T TL+V+++
Sbjct: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDK 310
>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
[Homo sapiens]
Length = 300
Score = 277 bits (708), Expect = 3e-74
Identities = 124/188 (65%), Positives = 155/188 (82%), Gaps = 6/188 (3%)
Query: 129 PSSGDDEDGED------EAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
PSS DD+D +D E ++T + APYWT PE+M+KKL AVPAA TV+F+CP++G P
Sbjct: 34 PSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 93
Query: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI TY
Sbjct: 94 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 153
Query: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD
Sbjct: 154 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 213
Query: 303 TPYVTVLK 310
PYV +LK
Sbjct: 214 LPYVQILK 221
>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
[Homo sapiens]
Length = 302
Score = 273 bits (698), Expect = 5e-73
Identities = 124/190 (65%), Positives = 154/190 (81%), Gaps = 8/190 (4%)
Query: 129 PSSGDDEDGEDEA-EDTGVDTG-------APYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
PSS DD+D +D + E+ D APYWT PE+M+KKL AVPAA TV+F+CP++G
Sbjct: 34 PSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG 93
Query: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
P P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI T
Sbjct: 94 TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHT 153
Query: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Y LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GP
Sbjct: 154 YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 213
Query: 301 DGTPYVTVLK 310
D PYV +LK
Sbjct: 214 DNLPYVQILK 223
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 249 bits (637), Expect = 6e-66
Identities = 137/306 (44%), Positives = 195/306 (63%), Gaps = 11/306 (3%)
Query: 480 LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 539
+GEG FGQV+ A I KD + A+K +K+ A+ D D E+E++ +G H N
Sbjct: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
Query: 540 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSC 599
IINLLGAC G LY+ +EYA GNL +FLR R D +F L+ + L+
Sbjct: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
Query: 600 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP 659
A VARGM+YL+ ++ IHRDLAARN+LV E+ V KIADFGL+R + Y K T GRLP
Sbjct: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
Query: 660 VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 719
V+WMA E+L VYT SDVWS+GVLLWEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
Query: 720 NCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDT 779
NC ++Y +MR+CW P +RP+F Q++ L+R+L T Y++ + +E+++ G D
Sbjct: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKT--YVNTTL-YEKFTYAGIDC 1118
Query: 780 PSSSSS 785
+ ++
Sbjct: 1119 SAEEAA 1124
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 249 bits (637), Expect = 6e-66
Identities = 150/349 (42%), Positives = 206/349 (59%), Gaps = 24/349 (6%)
Query: 442 IARLSSGEGPTLANVSELELPADP------KWELSRARLTLGKPLGEGCFGQVVMAEAIG 495
I + SSG TL +L +P +WE +T +GEG FGQV+ A
Sbjct: 808 ILQFSSG---TLTLTRRPKLQPEPLSYPVLEWE----DITFEDLIGEGNFGQVIRAM--- 857
Query: 496 IDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYV 555
I KD + A+KMLK+ A++ D D E+E++ +G H NIINLLGAC G LY+
Sbjct: 858 IKKD--GLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYI 915
Query: 556 LVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKC 615
+EYA GNL +FLR R D +F L+ + L+ A A GM+YL+ ++
Sbjct: 916 AIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQF 975
Query: 616 IHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTH 675
IHRDLAARNVLV E+ KIADFGL+R + Y K T GRLPV+WMA E+L VYT
Sbjct: 976 IHRDLAARNVLVGENLASKIADFGLSRGE---EVYVKKTMGRLPVRWMAIESLNYSVYTT 1032
Query: 676 QSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHA 735
+SDVWSFGVLLWEI +LGG+PY G+ EL++ L +G+RM++P NC ++Y +MR+CW
Sbjct: 1033 KSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRD 1092
Query: 736 APSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSS 784
P +RP F Q+ L R+L Y+++S FE ++ G D + +
Sbjct: 1093 RPYERPPFAQIALQLGRMLEARKA--YVNMSL-FENFTYAGIDATAEEA 1138
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,562,291
Number of Sequences: 37866
Number of extensions: 1835562
Number of successful extensions: 11813
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 697
Number of HSP's successfully gapped in prelim test: 370
Number of HSP's that attempted gapping in prelim test: 5800
Number of HSP's gapped (non-prelim): 3120
length of query: 808
length of database: 18,247,518
effective HSP length: 110
effective length of query: 698
effective length of database: 14,082,258
effective search space: 9829416084
effective search space used: 9829416084
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.