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Search of human proteins with 239835720
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
(593 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 1202 0.0
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 1183 0.0
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 1016 0.0
gi|166235129 kelch-like 3 [Homo sapiens] 929 0.0
gi|38194229 kelch-like 17 [Homo sapiens] 528 e-150
gi|40807500 kelch-like 20 [Homo sapiens] 469 e-132
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 439 e-123
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 439 e-123
gi|11056006 kelch-like 12 [Homo sapiens] 437 e-122
gi|55925604 kelch-like 18 [Homo sapiens] 423 e-118
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 414 e-115
gi|14780904 kelch-like 1 protein [Homo sapiens] 412 e-115
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 401 e-112
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 399 e-111
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 380 e-105
gi|34101268 kelch-like 8 [Homo sapiens] 375 e-104
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 366 e-101
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 366 e-101
gi|148664209 kelch-like 10 [Homo sapiens] 358 6e-99
gi|40018614 DRE1 protein [Homo sapiens] 321 1e-87
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 319 4e-87
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 311 1e-84
gi|239753890 PREDICTED: similar to kelch-like 2, Mayven (Drosoph... 305 6e-83
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 301 9e-82
gi|223890235 intracisternal A particle-promoted polypeptide isof... 300 2e-81
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 275 9e-74
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 275 9e-74
gi|55925608 kelch-like 21 [Homo sapiens] 262 7e-70
gi|45643138 kelch-like 13 [Homo sapiens] 261 1e-69
gi|24308181 kelch-like 9 [Homo sapiens] 260 3e-69
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 1202 bits (3111), Expect = 0.0
Identities = 593/593 (100%), Positives = 593/593 (100%)
Query: 1 METPPLPPACTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTI 60
METPPLPPACTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTI
Sbjct: 1 METPPLPPACTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTI 60
Query: 61 VAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQ 120
VAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQ
Sbjct: 61 VAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQ 120
Query: 121 VTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTY 180
VTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTY
Sbjct: 121 VTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTY 180
Query: 181 AEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMAR 240
AEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMAR
Sbjct: 181 AEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMAR 240
Query: 241 LMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLR 300
LMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLR
Sbjct: 241 LMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLR 300
Query: 301 TPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGG 360
TPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGG
Sbjct: 301 TPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGG 360
Query: 361 FNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAY 420
FNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAY
Sbjct: 361 FNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAY 420
Query: 421 NIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIA 480
NIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIA
Sbjct: 421 NIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIA 480
Query: 481 EMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCA 540
EMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCA
Sbjct: 481 EMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCA 540
Query: 541 VNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 593
VNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL
Sbjct: 541 VNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 593
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 1183 bits (3061), Expect = 0.0
Identities = 585/590 (99%), Positives = 586/590 (99%)
Query: 4 PPLPPACTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAE 63
P + CTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAE
Sbjct: 8 PQILFVCTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAE 67
Query: 64 DMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTE 123
DMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTE
Sbjct: 68 DMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTE 127
Query: 124 ENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQ 183
ENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQ
Sbjct: 128 ENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQ 187
Query: 184 HFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLME 243
HFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLME
Sbjct: 188 HFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLME 247
Query: 244 HVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPM 303
HVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPM
Sbjct: 248 HVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPM 307
Query: 304 NLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNG 363
NLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNG
Sbjct: 308 NLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNG 367
Query: 364 SLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIK 423
SLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIK
Sbjct: 368 SLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIK 427
Query: 424 SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMS 483
SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMS
Sbjct: 428 SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMS 487
Query: 484 TRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNG 543
TRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNG
Sbjct: 488 TRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNG 547
Query: 544 LLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 593
LLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL
Sbjct: 548 LLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 597
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 1016 bits (2628), Expect = 0.0
Identities = 505/505 (100%), Positives = 505/505 (100%)
Query: 89 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 148
MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 149 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 208
LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 209 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 268
DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 269 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF 328
SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF 240
Query: 329 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD 388
KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD
Sbjct: 241 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD 300
Query: 389 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 448
RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL
Sbjct: 301 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 360
Query: 449 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL 508
LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL
Sbjct: 361 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL 420
Query: 509 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 568
VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD
Sbjct: 421 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 480
Query: 569 KWTVVSSCMSTGRSYAGVTVIDKPL 593
KWTVVSSCMSTGRSYAGVTVIDKPL
Sbjct: 481 KWTVVSSCMSTGRSYAGVTVIDKPL 505
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 929 bits (2401), Expect = 0.0
Identities = 449/570 (78%), Positives = 513/570 (90%)
Query: 24 DNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHA 83
D+ + +TVNP HM KAFKVMNELRS+ LLCDV IVAED+EI AHRVVLAACSPYF A
Sbjct: 18 DDEKNQRTITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCA 77
Query: 84 MFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKK 143
MFTG+MSES+AK++ IK+VDG TL LIDY+YTAEI+VTEENVQVLLPAA LLQL DV++
Sbjct: 78 MFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQ 137
Query: 144 TCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVC 203
CC+FL+SQLHP NCLGIRAFAD+H CTDLL +AN YAEQHF +V+L EEFL+L ++QVC
Sbjct: 138 NCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVC 197
Query: 204 SLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEA 263
SLISSDKLT+SSEEKVFEAVI+W+N++K+ R E MA+LMEHVRLPLLPR+YLVQ VEEEA
Sbjct: 198 SLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEA 257
Query: 264 LVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSV 323
L+KN++ CKD+LIEAMKYHLLP +QR+L+K+ RT+ RTP++LPK+M+VVGGQAPKAIRSV
Sbjct: 258 LIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSV 317
Query: 324 ECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSV 383
ECYDF+E+RW Q+AELPSRRCRAG+V+MAG V+AVGGFNGSLRVRTVD YD VKDQWTS+
Sbjct: 318 ECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSI 377
Query: 384 ANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVG 443
A+M++RRSTLGAAVLN LLYAVGGFDGSTGL+SVEAY+ K+NEWF VAPMNTRRSSVGVG
Sbjct: 378 ASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVG 437
Query: 444 VVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG 503
VV G LYAVGGYDGASRQCLSTVE YN TNEW Y+A+MSTRRSGAGVGVL+ LYA GG
Sbjct: 438 VVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGG 497
Query: 504 HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYY 563
HDGPLVRKSVEVYDP TN W+QVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYY
Sbjct: 498 HDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYY 557
Query: 564 NPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 593
NP TDKWT++ + MSTGRSYAGV VI K L
Sbjct: 558 NPVTDKWTLLPTNMSTGRSYAGVAVIHKSL 587
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 528 bits (1359), Expect = e-150
Identities = 285/597 (47%), Positives = 378/597 (63%), Gaps = 14/597 (2%)
Query: 4 PPLPPAC----TKQGHQKPLDSKDD-----NTEKHCPVTVNPWHMKKAFKVMNELRSQNL 54
PP PPA T+ +P + + E H + H AF M+ +R + L
Sbjct: 31 PPQPPAPEAERTRPRQARPAAPMEGAVQLLSREGHSVAHNSKRHYHDAFVAMSRMRQRGL 90
Query: 55 LCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYV 114
LCD+ + EI AH+VVLA+CSPYFHAMFT EMSESR V + ++D L L+ +
Sbjct: 91 LCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFA 150
Query: 115 YTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLL 174
YTAEI V E NVQ LLPAA LLQL V+ CC+FL SQL P NCLGIR FAD H+C+DLL
Sbjct: 151 YTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADAHSCSDLL 210
Query: 175 NKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVR 234
A+ Y QHF DV +EEF+ L ++QV L+SSD L + SEE+V+ AV++WV HD D R
Sbjct: 211 KAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLSWVKHDVDAR 270
Query: 235 QEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKS 294
++ + RLM+ VRLPLL R++L+ V+ E+LV++ CKD LIEA+K+HLLP EQR ++ +
Sbjct: 271 RQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLP-EQRGVLGT 329
Query: 295 VRTRLRTPMNLPKLMVVVGGQAPKAIR-SVECYDFKEERWHQVAELPSRRCRAGMVYMAG 353
RTR R ++ VGG + AI E YD + +RWH VA + +RR R G+ +
Sbjct: 330 SRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGN 389
Query: 354 LVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTG 413
++AVGG++G+ + TV+SYDPV + W +M RRS LG A L+GLLY+ GG+DG++
Sbjct: 390 RLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASC 449
Query: 414 LSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATT 473
L+S E Y+ + W VA M+TRR V V + G LYAVGGYD +S L+TVE Y
Sbjct: 450 LNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSH--LATVEKYEPQV 507
Query: 474 NEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCR 533
N W+ +A M +RRS AGV VL LY GG+DG SVE Y P AW VA MN+ R
Sbjct: 508 NVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRR 567
Query: 534 RNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVID 590
+ A++G LY VGG+DGS +L S+E YNP T+KW V +SCM T RS GV V++
Sbjct: 568 STHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKW-VAASCMFTRRSSVGVAVLE 623
Score = 144 bits (363), Expect = 2e-34
Identities = 80/185 (43%), Positives = 110/185 (59%), Gaps = 2/185 (1%)
Query: 313 GGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDS 372
G + S E YD W VA + +RR + + G ++AVGG++ S + TV+
Sbjct: 443 GYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEK 502
Query: 373 YDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAP 432
Y+P + W+ VA+M RRS+ G AVL G LY GG DG++ L+SVE Y+ K+ W VAP
Sbjct: 503 YEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAP 562
Query: 433 MNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVG 492
MN RRS+ + + G LYAVGG DG+S L+++E YN TN+W + M TRRS GV
Sbjct: 563 MNIRRSTHDLVAMDGWLYAVGGNDGSSS--LNSIEKYNPRTNKWVAASCMFTRRSSVGVA 620
Query: 493 VLNNL 497
VL L
Sbjct: 621 VLELL 625
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 469 bits (1208), Expect = e-132
Identities = 255/554 (46%), Positives = 350/554 (63%), Gaps = 6/554 (1%)
Query: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
H ++ +V+N LR LCDV +V +I AHRV+L+ACSPYF AMFTGE++ESR V
Sbjct: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109
Query: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
I+++D + +LID+ YT++I V E NVQ LLPAA LLQL ++++ CCEFL+ QL P N
Sbjct: 110 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
Query: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
CLGIRAFAD H+C +LL A+ + + +F +V+ SEEF+ L Q+ +ISSD+L + SEE
Sbjct: 170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEE 229
Query: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
+VF AV+AWV + R+ + ++++HVRLPLL ++LV V + L+K+ C+D + E
Sbjct: 230 QVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDE 289
Query: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQ-APKAIRSVECYDFKEERWHQV 336
A Y LLP ++R LM+ RTR R P+ +++ VGG + AI SVE YD + W V
Sbjct: 290 AKNYLLLP-QERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMV 348
Query: 337 AELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTS-VANMRDRRSTLGA 395
A + RRC G+ + L++AVGG +GS + +V+ YDP +QW+S VA R+++G
Sbjct: 349 ASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGV 408
Query: 396 AVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGY 455
AVL G LYAVGG DG + L+ VE Y+ K N+W VA M+TRR V V V+GG LYAVGG
Sbjct: 409 AVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGS 468
Query: 456 DGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEV 515
DG S L+TVE YN N W IA M TRR G V +++YAVGG D S E
Sbjct: 469 DGTSP--LNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAER 526
Query: 516 YDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSS 575
Y+P TN W V M R G+ VNG L VGG DG+ L ++E ++P + W +
Sbjct: 527 YNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGG 586
Query: 576 CMSTGRSYAGVTVI 589
M+ R GV VI
Sbjct: 587 -MNYRRLGGGVGVI 599
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 439 bits (1128), Expect = e-123
Identities = 232/558 (41%), Positives = 343/558 (61%), Gaps = 12/558 (2%)
Query: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
H ++ FK M LCDV +VA D I AHR+VL++ S YF AMFT ++ E+R + +
Sbjct: 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 215
Query: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
+++ V+ +L LI Y YT +++ E+N++ LL A LLQL V + CC+FL QLHP N
Sbjct: 216 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 275
Query: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
CLGIR+FAD CTDL A+ Y +HF +V+ ++EF+ L ++ L++SD + I +EE
Sbjct: 276 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 335
Query: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
+ A++ WV HD + R++ +++L+ ++RLPLL ++L +E L ++ C+ ++E
Sbjct: 336 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIME 394
Query: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVA 337
AMKYHLLP E+R +++S RT+ R + L V G + K S+E YD + W VA
Sbjct: 395 AMKYHLLP-ERRPMLQSPRTKPR-KSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVA 452
Query: 338 ELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAV 397
+ RR + G+ + ++ VGG +G + TV+ Y+P W+ + M R LG AV
Sbjct: 453 NMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAV 512
Query: 398 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG 457
L G +YAVGG DG + L++VE ++ ++ +W VA M+T RS+VGV V+ G LYAVGG DG
Sbjct: 513 LEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDG 572
Query: 458 ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL------VRK 511
+S CL +VEC++ TN+WT A+MS RR G GV N LLYA+GGHD P +
Sbjct: 573 SS--CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSD 630
Query: 512 SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWT 571
VE YDP T+ W VA M++ R GVC + LY VGG DG L +VE Y+P T++WT
Sbjct: 631 CVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWT 690
Query: 572 VVSSCMSTGRSYAGVTVI 589
V+ + GR+ A V +
Sbjct: 691 QVAP-LCLGRAGACVVTV 707
Score = 35.8 bits (81), Expect = 0.11
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 543 GLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 593
G L+ VGG D + S+E Y+ T+ WT V++ M+ R GV V+D L
Sbjct: 421 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVAN-MNGRRLQFGVAVLDDKL 470
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 439 bits (1128), Expect = e-123
Identities = 232/558 (41%), Positives = 343/558 (61%), Gaps = 12/558 (2%)
Query: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
H ++ FK M LCDV +VA D I AHR+VL++ S YF AMFT ++ E+R + +
Sbjct: 202 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 261
Query: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
+++ V+ +L LI Y YT +++ E+N++ LL A LLQL V + CC+FL QLHP N
Sbjct: 262 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 321
Query: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
CLGIR+FAD CTDL A+ Y +HF +V+ ++EF+ L ++ L++SD + I +EE
Sbjct: 322 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 381
Query: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
+ A++ WV HD + R++ +++L+ ++RLPLL ++L +E L ++ C+ ++E
Sbjct: 382 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIME 440
Query: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVA 337
AMKYHLLP E+R +++S RT+ R + L V G + K S+E YD + W VA
Sbjct: 441 AMKYHLLP-ERRPMLQSPRTKPR-KSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVA 498
Query: 338 ELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAV 397
+ RR + G+ + ++ VGG +G + TV+ Y+P W+ + M R LG AV
Sbjct: 499 NMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAV 558
Query: 398 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG 457
L G +YAVGG DG + L++VE ++ ++ +W VA M+T RS+VGV V+ G LYAVGG DG
Sbjct: 559 LEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDG 618
Query: 458 ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL------VRK 511
+S CL +VEC++ TN+WT A+MS RR G GV N LLYA+GGHD P +
Sbjct: 619 SS--CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSD 676
Query: 512 SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWT 571
VE YDP T+ W VA M++ R GVC + LY VGG DG L +VE Y+P T++WT
Sbjct: 677 CVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWT 736
Query: 572 VVSSCMSTGRSYAGVTVI 589
V+ + GR+ A V +
Sbjct: 737 QVAP-LCLGRAGACVVTV 753
Score = 35.8 bits (81), Expect = 0.11
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 543 GLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 593
G L+ VGG D + S+E Y+ T+ WT V++ M+ R GV V+D L
Sbjct: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVAN-MNGRRLQFGVAVLDDKL 516
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 437 bits (1125), Expect = e-122
Identities = 242/559 (43%), Positives = 334/559 (59%), Gaps = 15/559 (2%)
Query: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
H K MN LR N LCDVT+ E + AHR+VLAACS YF AMFT E+SE V
Sbjct: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
Query: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
I+ + T+ +L+D+VYT + VT ENVQ LLPAA LLQL+ VK+ CCEFLESQL P N
Sbjct: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
Query: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
CLGIR FA+ H C DL+ A ++++HF +VV EEF+ L +V LI D++ + SEE
Sbjct: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
Query: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
VFEAVI WV H K R+E + L+++VR+PLL Y+ ++ E ++ S C+D + E
Sbjct: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
Query: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG----QAPKAIRSVECYDFKEERW 333
A K+HL P E R M+ RTR R N ++++VVGG Q+P I VE YD K + W
Sbjct: 255 AKKFHLRP-ELRSQMQGPRTRARLGAN--EVLLVVGGFGSQQSP--IDVVEKYDPKTQEW 309
Query: 334 HQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQ---WTSVANMRDRR 390
+ + +R V + ++ +GG++G R+ +V+ D D+ W SVA M RR
Sbjct: 310 SFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRR 369
Query: 391 STLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 450
GA L ++Y GGFDGS +S+E Y+ ++W + M T R G+ V G++Y
Sbjct: 370 GLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIY 429
Query: 451 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVR 510
+GGYDG + L++VE Y+ T WT + M+T+RSGAGV +LN+ +Y VGG DG
Sbjct: 430 CLGGYDGLN--ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHL 487
Query: 511 KSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKW 570
SVE Y+ T++W V M R G + G LY + G DG+ L+S+E Y+P D W
Sbjct: 488 SSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSW 547
Query: 571 TVVSSCMSTGRSYAGVTVI 589
VV+S M T R AGV V+
Sbjct: 548 EVVTS-MGTQRCDAGVCVL 565
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 423 bits (1088), Expect = e-118
Identities = 217/536 (40%), Positives = 323/536 (60%), Gaps = 5/536 (0%)
Query: 41 KAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIK 100
+ + VM E+R Q LCDVT+ D + SAHR+VLAA PYFHAMFT +M E + + ++
Sbjct: 23 RGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQ 82
Query: 101 EVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLG 160
+D L LI++ Y + + ++NVQ LL A LQLQ +K CC FL +LHP NCLG
Sbjct: 83 GMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
Query: 161 IRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVF 220
+R FA+ C L + AN++ QHF +V +SEEFL L +E V L+S D+L + SEE+VF
Sbjct: 143 VRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVF 202
Query: 221 EAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMK 280
EA +AWV +D++ R ++ L+ ++RLPL ++L RV+++ LV+ C+D + EA
Sbjct: 203 EAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKD 262
Query: 281 YHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG--QAPKAIRSVECYDFKEERWHQVAE 338
YHL+P E+R + + RTR R ++ L+ VGG A ++ VE +D W +
Sbjct: 263 YHLMP-ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRP 321
Query: 339 LPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVL 398
+ + R R G+ + GL++A+GG++G LR+ TV++Y+P D WT V +M +RS +G VL
Sbjct: 322 MTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVL 381
Query: 399 NGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGA 458
+G +Y GG+DG++ LSSVE Y+ ++++W V M++ RS+ GV V G +Y GG+DG
Sbjct: 382 DGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGL 441
Query: 459 SRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDP 518
Q S+VE YN T W A M +R G L + ++ GG+DG E+Y
Sbjct: 442 --QIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSS 499
Query: 519 TTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVS 574
+ W + M+ R + A G LY VGG DG NL+SVE Y+P TD WT ++
Sbjct: 500 VADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMA 555
Score = 136 bits (342), Expect = 6e-32
Identities = 71/146 (48%), Positives = 95/146 (65%), Gaps = 2/146 (1%)
Query: 445 VGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH 504
+ GL+YAVGG + A L+ VE ++ N W M+T RS GV V+N LLYA+GG+
Sbjct: 286 IAGLIYAVGGLNSAG-DSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGY 344
Query: 505 DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 564
DG L +VE Y+P T+ W +V MN R G ++G +YV GG DG+ +L+SVE Y+
Sbjct: 345 DGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYS 404
Query: 565 PTTDKWTVVSSCMSTGRSYAGVTVID 590
P TDKWTVV+S MS+ RS AGVTV +
Sbjct: 405 PETDKWTVVTS-MSSNRSAAGVTVFE 429
Score = 127 bits (318), Expect = 4e-29
Identities = 72/203 (35%), Positives = 109/203 (53%), Gaps = 2/203 (0%)
Query: 292 MKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYM 351
M S R+ + T + ++ V G ++ SVE Y + ++W V + S R AG+
Sbjct: 369 MNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVF 428
Query: 352 AGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGS 411
G ++ GG +G +V+ Y+ W A M ++R GAA L ++ GG+DGS
Sbjct: 429 EGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGS 488
Query: 412 TGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNA 471
LS E Y+ +++W + PM+TRRS V + G LYAVGGYDG S LS+VE Y+
Sbjct: 489 GFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSN--LSSVEMYDP 546
Query: 472 TTNEWTYIAEMSTRRSGAGVGVL 494
T+ WT++A M+ G GVG +
Sbjct: 547 ETDCWTFMAPMACHEGGVGVGCI 569
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 414 bits (1064), Expect = e-115
Identities = 219/532 (41%), Positives = 330/532 (62%), Gaps = 12/532 (2%)
Query: 64 DMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTE 123
+ + S+ R+VL++ S YF AMFT ++ E+R + ++++ V+ +L LI Y YT +++ E
Sbjct: 167 ESDSSSCRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKE 226
Query: 124 ENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQ 183
+N++ LL A LLQL V + CC+FL QLHP NCLGIR+FAD CTDL A+ Y +
Sbjct: 227 DNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTME 286
Query: 184 HFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLME 243
HF +V+ ++EF+ L ++ L++SD + I +EE + A++ WV HD + R++ +++L+
Sbjct: 287 HFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLA 346
Query: 244 HVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPM 303
++RLPLL ++L +E L ++ C+ ++EAMKYHLLP E+R +++S RT+ R
Sbjct: 347 YIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLP-ERRPMLQSPRTKPR-KS 403
Query: 304 NLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNG 363
+ L V G + K S+E YD + W VA + RR + G+ + ++ VGG +G
Sbjct: 404 TVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDG 463
Query: 364 SLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIK 423
+ TV+ Y+P W+ + M R LG AVL G +YAVGG DG + L++VE ++ +
Sbjct: 464 LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQ 523
Query: 424 SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMS 483
+ +W VA M+T RS+VGV V+ G LYAVGG DG+S CL +VEC++ TN+WT A+MS
Sbjct: 524 ARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS--CLKSVECFDPHTNKWTLCAQMS 581
Query: 484 TRRSGAGVGVLNNLLYAVGGHDGPL------VRKSVEVYDPTTNAWRQVADMNMCRRNAG 537
RR G GV N LLYA+GGHD P + VE YDP T+ W VA M++ R G
Sbjct: 582 KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG 641
Query: 538 VCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVI 589
VC + LY VGG DG L +VE Y+P T++WT V+ + GR+ A V +
Sbjct: 642 VCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAP-LCLGRAGACVVTV 692
Score = 35.8 bits (81), Expect = 0.11
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 543 GLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 593
G L+ VGG D + S+E Y+ T+ WT V++ M+ R GV V+D L
Sbjct: 406 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVAN-MNGRRLQFGVAVLDDKL 455
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 412 bits (1058), Expect = e-115
Identities = 224/561 (39%), Positives = 334/561 (59%), Gaps = 12/561 (2%)
Query: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
H ++ F+ M Q LCDV ++ + +I AHR+VL++ S YF AMFT ++ E++ + +
Sbjct: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEI 253
Query: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
+++ +D L L+ + YT +++ E+ ++ LL AA LLQL V + CC FL LHP N
Sbjct: 254 KMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSN 313
Query: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
CLGIRAFAD C +L+ A++Y ++ +V+ ++EFL L E++ L++SD + + EE
Sbjct: 314 CLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEE 373
Query: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
+F A++ WV +D R ++ L+ +RLPLLP + L +E AL KN C+ ++E
Sbjct: 374 TIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILE 432
Query: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVA 337
AMKYHLLP E+R LM+S RT+ R + L V G K ++E YD + W Q
Sbjct: 433 AMKYHLLP-ERRTLMQSPRTKPR-KSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAG 490
Query: 338 ELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAV 397
+ RR + G+ + +F +GG +G + TV+ Y+P WT + M R LG V
Sbjct: 491 MMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTV 550
Query: 398 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG 457
L G +YAVGG DG + L++VE ++ +S +W VA M+ RS+VGV + G LY+VGG DG
Sbjct: 551 LEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDG 610
Query: 458 ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL------VRK 511
+S CLS++E Y+ TN+W A M RR G GV + LYAVGGHD P +
Sbjct: 611 SS--CLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLD 668
Query: 512 SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWT 571
VE YDP T+ W VA ++M R GVC + LY VGG DG L ++E Y+P T++WT
Sbjct: 669 YVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWT 728
Query: 572 VVSSCMSTGRSYAGVTVIDKP 592
++S ++ GR+ A V VI +P
Sbjct: 729 QMAS-LNIGRAGACVVVIKQP 748
Score = 78.2 bits (191), Expect = 2e-14
Identities = 44/96 (45%), Positives = 55/96 (57%), Gaps = 1/96 (1%)
Query: 498 LYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNL 557
LYAVGG D ++E YD TN W Q MN R GV ++ L+V+GG DG L
Sbjct: 461 LYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTL 520
Query: 558 ASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 593
+VE YNP T WTV+ MST R GVTV++ P+
Sbjct: 521 NTVECYNPKTKTWTVLPP-MSTHRHGLGVTVLEGPI 555
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 401 bits (1031), Expect = e-112
Identities = 221/561 (39%), Positives = 325/561 (57%), Gaps = 12/561 (2%)
Query: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
H ++ + M + LCDV ++A + I AHR+VL+A S YF AMFT ++ E++ + V
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
Query: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
R++ VD L L+ Y YT +Q+ E+ ++ LL AA LLQL V C FL QLHP N
Sbjct: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
Query: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
CLGIR+F D CT+LLN A+ Y +HF +V+ ++EFL L ++ L+ SD + + EE
Sbjct: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
Query: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
+F A++ WV HD RQ + L+ ++RLPLLP + L +E ++ C+ L+E
Sbjct: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLME 402
Query: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVA 337
AMKYHLLP E+R +M+S RT+ R + L V G A K ++E YD + W +
Sbjct: 403 AMKYHLLP-ERRSMMQSPRTKPR-KSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIG 460
Query: 338 ELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAV 397
+ RR + G+ + ++ VGG +G + TV+ ++PV WT + M R LG A
Sbjct: 461 TMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVAT 520
Query: 398 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG 457
L G +YAVGG DG + L++VE ++ + +W +VA M+T RS+VGV + LYA+GG DG
Sbjct: 521 LEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDG 580
Query: 458 ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL------VRK 511
+S CL ++E ++ TN+W+ A MS RR G GV N LY VGGHD P +
Sbjct: 581 SS--CLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSD 638
Query: 512 SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWT 571
VE YDP ++W VA +++ R VC + LYVVGG DG L +VE Y+ ++W
Sbjct: 639 CVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698
Query: 572 VVSSCMSTGRSYAGVTVIDKP 592
++ GR+ A V V+ P
Sbjct: 699 -EEVPVNIGRAGACVVVVKLP 718
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 399 bits (1025), Expect = e-111
Identities = 215/539 (39%), Positives = 315/539 (58%), Gaps = 11/539 (2%)
Query: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
H ++ + M + LCDV ++A + I AHR+VL+A S YF AMFT ++ E++ + V
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
Query: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
R++ VD L L+ Y YT +Q+ E+ ++ LL AA LLQL V C FL QLHP N
Sbjct: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
Query: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
CLGIR+F D CT+LLN A+ Y +HF +V+ ++EFL L ++ L+ SD + + EE
Sbjct: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
Query: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
+F A++ WV HD RQ + L+ ++RLPLLP + L +E ++ C+ L+E
Sbjct: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLME 402
Query: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVA 337
AMKYHLLP E+R +M+S RT+ R + L V G A K ++E YD + W +
Sbjct: 403 AMKYHLLP-ERRSMMQSPRTKPR-KSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIG 460
Query: 338 ELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAV 397
+ RR + G+ + ++ VGG +G + TV+ ++PV WT + M R LG A
Sbjct: 461 TMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVAT 520
Query: 398 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG 457
L G +YAVGG DG + L++VE ++ + +W +VA M+T RS+VGV + LYA+GG DG
Sbjct: 521 LEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDG 580
Query: 458 ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL------VRK 511
+S CL ++E ++ TN+W+ A MS RR G GV N LY VGGHD P +
Sbjct: 581 SS--CLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSD 638
Query: 512 SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKW 570
VE YDP ++W VA +++ R VC + LYVVGG DG L +VE Y+ ++W
Sbjct: 639 CVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
Score = 168 bits (426), Expect = 1e-41
Identities = 89/200 (44%), Positives = 118/200 (59%), Gaps = 9/200 (4%)
Query: 387 RDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 446
+ R+ST+GA LYAVGG D G +++E Y++++N W H+ MN RR GV V+
Sbjct: 422 KPRKSTVGA------LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVID 475
Query: 447 GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDG 506
LY VGG DG + L+TVEC+N WT + MST R G GV L +YAVGGHDG
Sbjct: 476 NKLYVVGGRDGL--KTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDG 533
Query: 507 PLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPT 566
+VE +DP W VA M+ R GV A+N LY +GG DGS L S+EY++P
Sbjct: 534 WSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPH 593
Query: 567 TDKWTVVSSCMSTGRSYAGV 586
T+KW++ + MS R GV
Sbjct: 594 TNKWSLCAP-MSKRRGGVGV 612
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 380 bits (976), Expect = e-105
Identities = 207/543 (38%), Positives = 315/543 (58%), Gaps = 16/543 (2%)
Query: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
H ++ + +N LR + LCD+ + D++I AH+VVLA+ SPYF AMFTG +SE V
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
+ +D L+ +++Y YT + ++++ V+ LLPAA LLQ++ V K CC FLESQL P N
Sbjct: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
Query: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
C+GI FA+ + C DL A Y Q+F V +EEF L + ++S+D L +++EE
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
Query: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
VF A+ +W+ +D RQ+++A+L+ VRLPLL ++L + E L+++ CK L E
Sbjct: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
Query: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAP--KAIRSVECYDFKEERWHQ 335
A+KYH +P E R+ ++V + P PK++ VGG++ + SVE Y + + W
Sbjct: 257 ALKYHFMP-EHRLSHQTV--LMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWIG 313
Query: 336 VAELPSRRCRAGMVYMAGLVFAVGGFNGSLR--------VRTVDSYDPVKDQWTSVANMR 387
+A L R G+ + V+ +GG ++R +V+ ++P + WTS+ M
Sbjct: 314 LAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMN 373
Query: 388 DRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG 447
+ RSTLG VL G LYA+GG+DG + L SVE Y K +W VAPM T RS V+ G
Sbjct: 374 ESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDG 433
Query: 448 LLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGP 507
++YA+GGY A +++VE Y+ + + W +A M+ +R GVGV+ ++ VGGH+G
Sbjct: 434 MIYAIGGYGPAH---MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGV 490
Query: 508 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTT 567
S+E YDP N W M R G ++ LYVVGG GS L +V+ Y+P +
Sbjct: 491 SHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPIS 550
Query: 568 DKW 570
D W
Sbjct: 551 DTW 553
Score = 101 bits (252), Expect = 2e-21
Identities = 50/138 (36%), Positives = 80/138 (57%)
Query: 305 LPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGS 364
L ++ +GG P + SVE YD ++ W VA + +R G+ M G +F VGG NG
Sbjct: 431 LDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGV 490
Query: 365 LRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKS 424
+ +++ YDP ++QWT M++ R+ +GAAV++ LY VGG GS+ L++V+ Y+ S
Sbjct: 491 SHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPIS 550
Query: 425 NEWFHVAPMNTRRSSVGV 442
+ W A M R + G+
Sbjct: 551 DTWLDSAGMIYCRCNFGL 568
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 375 bits (962), Expect = e-104
Identities = 201/536 (37%), Positives = 315/536 (58%), Gaps = 5/536 (0%)
Query: 55 LCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYV 114
LCDVT+ IS H++VLA PYF AMF EM+E++ + I++ DG + L+ +V
Sbjct: 66 LCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFV 125
Query: 115 YTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLL 174
Y++ + +T +NVQ LL AA +LQ++ V + CCE+++ HP NCL +RAFA+ H DL+
Sbjct: 126 YSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLM 185
Query: 175 NKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVR 234
+ A+ YA HF +VV E+F+++ + + L+SS L I +E++V+ A I W+ +
Sbjct: 186 DMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 245
Query: 235 QEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKS 294
+++ + VRLPLLP ++L+ V +E +VK + C+D L EA YHL + + +
Sbjct: 246 SKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFE 305
Query: 295 VRTRLRTPMNLPKLMVVVGGQAPKA--IRSVECYDFKEERWHQVAELPSRRCRAGMVYMA 352
R + ++ VGG+ RS+ECY + W E+ SRR G++ +
Sbjct: 306 YSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVE 365
Query: 353 GLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGST 412
G V+AVGG +G+ + +++ +DP+ ++W A+M +R + A L G +YA+GG D +T
Sbjct: 366 GKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNT 425
Query: 413 GLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNAT 472
+ VE Y+I+S++W VAPMNT R VG + +YAVGG DG + LS+VE Y+
Sbjct: 426 CFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMA--SLSSVERYDPH 483
Query: 473 TNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMC 532
++W + EM RR+G GV L+ LY VGG D SVE YDP +N W VA +
Sbjct: 484 LDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTP 543
Query: 533 RRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTV 588
R G+ V G ++ VGG +G+ L +VE ++P ++W +V S +S R+ AGV V
Sbjct: 544 RGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGS-VSHCRAGAGVAV 598
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 366 bits (939), Expect = e-101
Identities = 217/564 (38%), Positives = 313/564 (55%), Gaps = 19/564 (3%)
Query: 38 HMKKAFKVMNELRSQNLLCDVTIV-----AEDMEISAHRVVLAACSPYFHAMFTGEMSES 92
H K+AF +MNELR LCDVT+ A + AH+VVLA+ SP F AMFT + E
Sbjct: 59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
Query: 93 RAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQ 152
+ V I+ + + LI++ YTA I + E+ V ++ A + Q+ V + C +FL Q
Sbjct: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
Query: 153 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLT 212
L P N +GI FA+ C +L +A Y HF +V EEF NL Q+ +LIS D L
Sbjct: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
Query: 213 ISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACK 272
+ E +VF A I WV +D + R+ ++ L+ VR L +L ++++ ++++ S CK
Sbjct: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
Query: 273 DYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEER 332
DYL++ E+ L K + + +L+ GG +++ +E Y+ +
Sbjct: 299 DYLVKIF-------EELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGT 351
Query: 333 WHQVAELPSRRCRAGMVYMAGLVFAVGGFN----GSLRVRTVDSYDPVKDQWTSVANMRD 388
W ++A+L R + GL++AVGG N G+ +D Y+P+ +QW+ A M
Sbjct: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSV 411
Query: 389 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 448
R+ +G V++G +YAVGG G +SVE Y + +EW VAPM TRR VGV V+ L
Sbjct: 412 PRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
Query: 449 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL 508
LYAVGG+DG +R L++ ECY NEW I M+T RSGAGV VL+N +YA GG+DG
Sbjct: 472 LYAVGGFDGTNR--LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
Query: 509 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 568
SVE YD T W VA M R G+ G +YV+GG DG L SVE Y+P TD
Sbjct: 530 QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
Query: 569 KWTVVSSCMSTGRSYAGVTVIDKP 592
W+ V+ M++GRS GV V +P
Sbjct: 590 TWSEVTR-MTSGRSGVGVAVTMEP 612
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 366 bits (939), Expect = e-101
Identities = 217/564 (38%), Positives = 313/564 (55%), Gaps = 19/564 (3%)
Query: 38 HMKKAFKVMNELRSQNLLCDVTIV-----AEDMEISAHRVVLAACSPYFHAMFTGEMSES 92
H K+AF +MNELR LCDVT+ A + AH+VVLA+ SP F AMFT + E
Sbjct: 59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
Query: 93 RAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQ 152
+ V I+ + + LI++ YTA I + E+ V ++ A + Q+ V + C +FL Q
Sbjct: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
Query: 153 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLT 212
L P N +GI FA+ C +L +A Y HF +V EEF NL Q+ +LIS D L
Sbjct: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
Query: 213 ISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACK 272
+ E +VF A I WV +D + R+ ++ L+ VR L +L ++++ ++++ S CK
Sbjct: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
Query: 273 DYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEER 332
DYL++ E+ L K + + +L+ GG +++ +E Y+ +
Sbjct: 299 DYLVKIF-------EELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGT 351
Query: 333 WHQVAELPSRRCRAGMVYMAGLVFAVGGFN----GSLRVRTVDSYDPVKDQWTSVANMRD 388
W ++A+L R + GL++AVGG N G+ +D Y+P+ +QW+ A M
Sbjct: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSV 411
Query: 389 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 448
R+ +G V++G +YAVGG G +SVE Y + +EW VAPM TRR VGV V+ L
Sbjct: 412 PRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
Query: 449 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL 508
LYAVGG+DG +R L++ ECY NEW I M+T RSGAGV VL+N +YA GG+DG
Sbjct: 472 LYAVGGFDGTNR--LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
Query: 509 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 568
SVE YD T W VA M R G+ G +YV+GG DG L SVE Y+P TD
Sbjct: 530 QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
Query: 569 KWTVVSSCMSTGRSYAGVTVIDKP 592
W+ V+ M++GRS GV V +P
Sbjct: 590 TWSEVTR-MTSGRSGVGVAVTMEP 612
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 358 bits (920), Expect = 6e-99
Identities = 202/562 (35%), Positives = 304/562 (54%), Gaps = 20/562 (3%)
Query: 19 LDSKDDNTEKHCPVTVNPWHMKK-----AFKVMNELRSQNLLCDVTIVAEDMEISAHRVV 73
++S +T H P HM++ A ++ NELR + LCDV I E SAH+ +
Sbjct: 3 MESAAASTRFHQP------HMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNI 56
Query: 74 LAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAA 133
L +CS YF A+FT + + K I + ++++I+Y YT + +T +NV+ LL AA
Sbjct: 57 LCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAA 116
Query: 134 GLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVV-LSE 192
+ + + CCEFL+S+L NC+GI F D + C +L KA + +F ++V +S
Sbjct: 117 DQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSA 176
Query: 193 EFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPR 252
EFL L + ++ +I D+L + E+ VFEA++ W++HD R++ ++ L+ VRL L+
Sbjct: 177 EFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHA 236
Query: 253 EYLVQRVEEEALVKNSSACKDYLIEAMK--YHL-LPTEQRILMKSVRTRLRTPMNLPKLM 309
EY + V+ VK+S CK +I A+K Y L + + TR R P + L
Sbjct: 237 EYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAI--LF 294
Query: 310 VVVGGQAPKAIRSVECYDFKEERWHQV-AELPSRRCRAGMVYMAGLVFAVGGFNGSLRVR 368
+ G ++E YD + +RW V E S R G Y+ G V+ +GGF+
Sbjct: 295 AIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFN 354
Query: 369 TVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWF 428
+V +DPVK W VA M RR + VL +YA+GGFDG L++ E Y ++N+W
Sbjct: 355 SVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWT 414
Query: 429 HVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSG 488
+APM+ +RS + G +Y GG++G +CL T E YN +N+WT IA M +RRSG
Sbjct: 415 LIAPMHEQRSDASATTLYGKVYICGGFNG--NECLFTAEVYNTESNQWTVIAPMRSRRSG 472
Query: 489 AGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVV 548
GV +YAVGG DG +S E Y P N WR + M R N G+ V+ LL+VV
Sbjct: 473 IGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVV 532
Query: 549 GGDDGSCNLASVEYYNPTTDKW 570
GG +G +VE Y+ TD+W
Sbjct: 533 GGFNGFTTTFNVECYDEKTDEW 554
Score = 114 bits (284), Expect = 3e-25
Identities = 61/187 (32%), Positives = 107/187 (57%), Gaps = 4/187 (2%)
Query: 401 LLYAVGGFDGSTGLSSVEAYNIKSNEWFHVA-PMNTRRSSVGVGVVGGLLYAVGGYDGAS 459
+L+A+GG+ G + +++EAY+ +++ W +V + R+ G + G +Y +GG+D S
Sbjct: 292 ILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFD--S 349
Query: 460 RQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPT 519
++V+ ++ W +A M +RR V VL N +YA+GG DG + + E Y+P
Sbjct: 350 VDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPE 409
Query: 520 TNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMST 579
TN W +A M+ R +A + G +Y+ GG +G+ L + E YN +++WTV++ M +
Sbjct: 410 TNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAP-MRS 468
Query: 580 GRSYAGV 586
RS GV
Sbjct: 469 RRSGIGV 475
Score = 99.4 bits (246), Expect = 8e-21
Identities = 49/142 (34%), Positives = 84/142 (59%)
Query: 307 KLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLR 366
K+ + G + + + E Y+ + +W +A + SRR G++ V+AVGGF+G+ R
Sbjct: 434 KVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANR 493
Query: 367 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNE 426
+R+ ++Y PV + W ++ M + RS G V++ LL+ VGGF+G T +VE Y+ K++E
Sbjct: 494 LRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDE 553
Query: 427 WFHVAPMNTRRSSVGVGVVGGL 448
W+ M+ RS++ VV GL
Sbjct: 554 WYDAHDMSIYRSALSCCVVPGL 575
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 321 bits (822), Expect = 1e-87
Identities = 204/559 (36%), Positives = 278/559 (49%), Gaps = 19/559 (3%)
Query: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
H + ++ NE R L DV I E E HR VL+ACS YF AMF + ESR V
Sbjct: 48 HAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLV 107
Query: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
I + + + YVYT ++++T ENVQ L + L Q+ ++ C +FLE QL P N
Sbjct: 108 EINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCN 167
Query: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
CLGI+ FAD H+ L K +A Q F DV EEFL L +++ I SD+L I EE
Sbjct: 168 CLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEE 227
Query: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
VFEAV+ WV D+R+ + L+ HVRLPLL Y VQ VE + L++NS C L E
Sbjct: 228 MVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHE 287
Query: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKA---IRSVECYDFKEERWH 334
A +YH+L E M S RTR R +++VVVGG + ECYD W
Sbjct: 288 ARRYHILGNE----MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWK 343
Query: 335 QVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLG 394
+A+LP V V G G + R V Y+ + W VA++ R
Sbjct: 344 SLAKLPEFTKSEYAVCALRNDILVSG--GRINSRDVWIYNSQLNIWIRVASLNKGRWRHK 401
Query: 395 AAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGG 454
AVL G +Y VGG+DG LSSVE Y+ SN W VAP+ SS V G L+ +GG
Sbjct: 402 MAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGG 461
Query: 455 YDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVE 514
C V+ Y+ TN W A + + LNNL+Y GG + K++
Sbjct: 462 -GPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG-----LTKAIY 515
Query: 515 VYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG--DDGSCNLASVEYYNPTTDKWTV 572
YDP + W V + + N G+ NG +Y++GG ++G ++ Y+P T T
Sbjct: 516 CYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEAT-DTILCYDPATSIITG 574
Query: 573 VSSCMSTGRSYAGVTVIDK 591
V++ M SY G I +
Sbjct: 575 VAA-MPRPVSYHGCVTIHR 592
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 319 bits (818), Expect = 4e-87
Identities = 193/568 (33%), Positives = 297/568 (52%), Gaps = 18/568 (3%)
Query: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
H + +N++R+ CDV + AHR+VLAA SPYF A+FTG M ES V
Sbjct: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
Query: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
I ++ ++L+D++YT + + NVQ L+ AA +LQL +V CCEFL+ Q+ P+N
Sbjct: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
Query: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
C+GI F++ AC DLL + Y HF +V EEFL L +Q+ ++ S++L+I E
Sbjct: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEY 198
Query: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
+VF A + W+ D R++ + +++ +R PLLP + L++ +E + A + L E
Sbjct: 199 QVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKE 258
Query: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQA---------PKAIRSVECYDF 328
+ P E + +++R K + VGG +A+ VE +D
Sbjct: 259 YCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDT 318
Query: 329 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD 388
+ W V+ L R G+ + G+V+A+GG S+ + YDPV QWT+VA+M
Sbjct: 319 FSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNH 378
Query: 389 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 448
R LG V G +YA+GG+ G+ +++E ++ N+W V M R G + GL
Sbjct: 379 PRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGL 438
Query: 449 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG-HDGP 507
+Y +GG + L + E Y+ + W+ + M TRR+ GV LN+ +Y+VGG ++
Sbjct: 439 IYVIGGISNEGIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ 497
Query: 508 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN------LASVE 561
+VE Y W +VA M + R V AVNGLLYV GG S + L SVE
Sbjct: 498 DALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVE 557
Query: 562 YYNPTTDKWTVVSSCMSTGRSYAGVTVI 589
YNP +D WT + + M T R GV V+
Sbjct: 558 VYNPHSDTWTEIGN-MITSRCEGGVAVL 584
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 311 bits (797), Expect = 1e-84
Identities = 180/550 (32%), Positives = 292/550 (53%), Gaps = 11/550 (2%)
Query: 45 VMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDG 104
VMN +R Q LCDV ++ ++ +I AHRVVLAA S +F+ MFT M ES++ V +K+ +
Sbjct: 33 VMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEP 92
Query: 105 WTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAF 164
+ L+++ YTA I V NVQ LL AA Q++ VKK C +FL+ Q+ NCLGI
Sbjct: 93 DIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVL 152
Query: 165 ADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVI 224
A+ C +L A+ + QHF +V ++EFL L +++V L++ D LT+ +E++V++A +
Sbjct: 153 AECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAV 212
Query: 225 AWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLL 284
W+ +D+ RQ FM ++ VR PL+ + +L + V+ E L++++ C +I M+YHLL
Sbjct: 213 RWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLL 272
Query: 285 -PTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRR 343
P ++ L+ R R + + + GG P++ R ++ K+ W + +R
Sbjct: 273 SPEDREELVDGTRPRRK---KHDYRIALFGGSQPQSCR---YFNPKDYSWTDIRCPFEKR 326
Query: 344 CRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLY 403
A V+ +V+ +GG + ++ +D Y+ VKD W S R +L A G +Y
Sbjct: 327 RDAACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIY 385
Query: 404 AVGGFD-GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG--ASR 460
GG + G++ L E Y+ ++ W M T+R S G+ GL+Y GG G S
Sbjct: 386 TSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSG 445
Query: 461 QCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTT 520
+ L++ E Y+ T WT + M R G+ + + ++AVGG +G +VE YD
Sbjct: 446 RVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKL 505
Query: 521 NAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTG 580
N W+ V+ M AV ++YV+ G G L + YN TDKW S +
Sbjct: 506 NEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFP 565
Query: 581 RSYAGVTVID 590
+ + V+D
Sbjct: 566 VTSCLICVVD 575
Score = 63.5 bits (153), Expect = 5e-10
Identities = 53/195 (27%), Positives = 79/195 (40%), Gaps = 11/195 (5%)
Query: 403 YAVGGFDGSTGLSSVEAYNIKSNEWFHV-APMNTRRSSVGVGVVGGLLYAVGGYDGASRQ 461
Y + F GS S +N K W + P RR + V ++Y +GG +
Sbjct: 293 YRIALFGGSQP-QSCRYFNPKDYSWTDIRCPFEKRRDAACV-FWDNVVYILGG---SQLF 347
Query: 462 CLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-GPLVRKSVEVYDPTT 520
+ ++CYN + W T R +Y GG + G E YD T
Sbjct: 348 PIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRT 407
Query: 521 NAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN----LASVEYYNPTTDKWTVVSSC 576
+W M R + G+ NGL+YV GG G+ L S E Y+P T+ WT +
Sbjct: 408 ESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPM 467
Query: 577 MSTGRSYAGVTVIDK 591
+ +++ V V DK
Sbjct: 468 IEARKNHGLVFVKDK 482
>gi|239753890 PREDICTED: similar to kelch-like 2, Mayven
(Drosophila) [Homo sapiens]
Length = 211
Score = 305 bits (782), Expect = 6e-83
Identities = 153/181 (84%), Positives = 154/181 (85%), Gaps = 19/181 (10%)
Query: 1 METPPLPPACTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTI 60
M P + CTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTI
Sbjct: 1 MAVPLVTLLCTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTI 60
Query: 61 VAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQ 120
VAEDMEISAHRVVLAACSPYFHAMFTG MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQ
Sbjct: 61 VAEDMEISAHRVVLAACSPYFHAMFTGGMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQ 120
Query: 121 VTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTY 180
VTEEN CEFLESQLHPVNCLGIRAFADMHACTDLLNKANTY
Sbjct: 121 VTEENT-------------------CEFLESQLHPVNCLGIRAFADMHACTDLLNKANTY 161
Query: 181 A 181
A
Sbjct: 162 A 162
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 301 bits (772), Expect = 9e-82
Identities = 175/548 (31%), Positives = 289/548 (52%), Gaps = 11/548 (2%)
Query: 47 NELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWT 106
+ + + LCDV ++ ++ +I AHRVVLAA S +F+ MFT M ES++ V +K+ +
Sbjct: 13 SHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDI 72
Query: 107 LRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFAD 166
+ L+++ YTA I V NVQ LL AA Q++ VKK C +FL+ Q+ NCLGI A+
Sbjct: 73 IEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAE 132
Query: 167 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAW 226
C +L A+ + QHF +V ++EFL L +++V L++ D LT+ +E++V++A + W
Sbjct: 133 CLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 192
Query: 227 VNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLL-P 285
+ +D+ RQ FM ++ VR PL+ + +L + V+ E L++++ C +I M+YHLL P
Sbjct: 193 LKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSP 252
Query: 286 TEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCR 345
++ L+ R R + + + GG P++ R ++ K+ W + +R
Sbjct: 253 EDREELVDGTRPRRK---KHDYRIALFGGSQPQSCR---YFNPKDYSWTDIRCPFEKRRD 306
Query: 346 AGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAV 405
A V+ +V+ +GG + ++ +D Y+ VKD W S R +L A G +Y
Sbjct: 307 AACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTS 365
Query: 406 GGFD-GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG--ASRQC 462
GG + G++ L E Y+ ++ W M T+R S G+ GL+Y GG G S +
Sbjct: 366 GGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRV 425
Query: 463 LSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNA 522
L++ E Y+ T WT + M R G+ + + ++AVGG +G +VE YD N
Sbjct: 426 LNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNE 485
Query: 523 WRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRS 582
W+ V+ M AV ++YV+ G G L + YN TDKW S + +
Sbjct: 486 WKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVT 545
Query: 583 YAGVTVID 590
+ V+D
Sbjct: 546 SCLICVVD 553
Score = 63.5 bits (153), Expect = 5e-10
Identities = 53/195 (27%), Positives = 79/195 (40%), Gaps = 11/195 (5%)
Query: 403 YAVGGFDGSTGLSSVEAYNIKSNEWFHV-APMNTRRSSVGVGVVGGLLYAVGGYDGASRQ 461
Y + F GS S +N K W + P RR + V ++Y +GG +
Sbjct: 271 YRIALFGGSQP-QSCRYFNPKDYSWTDIRCPFEKRRDAACV-FWDNVVYILGG---SQLF 325
Query: 462 CLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-GPLVRKSVEVYDPTT 520
+ ++CYN + W T R +Y GG + G E YD T
Sbjct: 326 PIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRT 385
Query: 521 NAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN----LASVEYYNPTTDKWTVVSSC 576
+W M R + G+ NGL+YV GG G+ L S E Y+P T+ WT +
Sbjct: 386 ESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPM 445
Query: 577 MSTGRSYAGVTVIDK 591
+ +++ V V DK
Sbjct: 446 IEARKNHGLVFVKDK 460
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 300 bits (768), Expect = 2e-81
Identities = 180/545 (33%), Positives = 284/545 (52%), Gaps = 16/545 (2%)
Query: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
H + +N++R+ CDV + AHR+VLAA SPYF A+FTG M ES V
Sbjct: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
Query: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
I ++ ++L+D++YT + + NVQ L+ AA +LQL +V CCEFL+ Q+ P+N
Sbjct: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
Query: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
C+GI F++ AC DLL + Y HF +V EEFL L +Q+ ++ S++L+I E
Sbjct: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEY 198
Query: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
+VF A + W+ D R++ + +++ +R PLLP + L++ +E + A + L E
Sbjct: 199 QVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKE 258
Query: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQA---------PKAIRSVECYDF 328
+ P E + +++R K + VGG +A+ VE +D
Sbjct: 259 YCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDT 318
Query: 329 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD 388
+ W V+ L R G+ + G+V+A+GG S+ + YDPV QWT+VA+M
Sbjct: 319 FSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNH 378
Query: 389 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 448
R LG V G +YA+GG+ G+ +++E ++ N+W V M R G + GL
Sbjct: 379 PRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGL 438
Query: 449 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG-HDGP 507
+Y +GG + L + E Y+ + W+ + M TRR+ GV LN+ +Y+VGG ++
Sbjct: 439 IYVIGGISNEGIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ 497
Query: 508 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTT 567
+VE Y W +VA M + R V AVNGLLYV GG +S ++ P T
Sbjct: 498 DALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG-----RSSSHDFLAPDT 552
Query: 568 DKWTV 572
++ V
Sbjct: 553 HRYEV 557
Score = 95.9 bits (237), Expect = 9e-20
Identities = 53/143 (37%), Positives = 76/143 (53%), Gaps = 7/143 (4%)
Query: 449 LYAVGGYDG------ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVG 502
LYAVGGY + + LS VE ++ + WT ++ + RSG GV VL ++YA+G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 503 GHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEY 562
G ++ E YDP T W VA MN R GVC G +Y +GG G+ ++E
Sbjct: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
Query: 563 YNPTTDKWTVVSSCMSTGRSYAG 585
++P +KW VV + M+ R Y G
Sbjct: 410 FDPDENKWEVVGN-MAVSRYYFG 431
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 275 bits (703), Expect = 9e-74
Identities = 168/553 (30%), Positives = 275/553 (49%), Gaps = 21/553 (3%)
Query: 35 NPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSES-- 92
+P H ++ K +N+ R D+ IV E E H+ VLA+CS YF + + +S
Sbjct: 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQ 367
Query: 93 --RAK-RVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFL 149
R K + + + L +L+++VYT + + N + LL AA Q K C FL
Sbjct: 368 GGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Query: 150 ESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSD 209
E QL NCLG+ A A+ C++L + A +A Q F +V EE L++ + + +S+D
Sbjct: 428 EKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSND 487
Query: 210 KLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSS 269
L +EE V+E VI W+ D R ++ A L+ VRLP + YL+ V+ E L+K+S
Sbjct: 488 SLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSE 547
Query: 270 ACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQ-----APKAIRSVE 324
AC+D + EA +YH+LP R M++ RTR R + +++V+VGG+ +++ +V
Sbjct: 548 ACRDLVNEAKRYHMLP-HARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVT 606
Query: 325 CYDFKEERWHQVAELPSRRCRAGMVYMAG-LVFAVGGFNGSLRVRTVDSYDPVKDQWTSV 383
C++ + +W+ +A LP V AG ++ GG + + V Y + D W V
Sbjct: 607 CWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
Query: 384 ANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVG 443
+ M R + V +G +Y +GG + + VE Y+ +N+W VAP+ S
Sbjct: 667 SRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAAT 726
Query: 444 VVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG 503
V GG +Y GG + A R ++ Y TN W++I A LN ++ +GG
Sbjct: 727 VCGGKIYVFGGVNEAGR-AAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG 785
Query: 504 HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG---DDGSCNLASV 560
++ +YDP + +MN R+ ++G +Y GG +G L ++
Sbjct: 786 ----AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPA-LGNM 840
Query: 561 EYYNPTTDKWTVV 573
E Y PTT+ WT++
Sbjct: 841 EAYEPTTNTWTLL 853
Score = 50.1 bits (118), Expect = 6e-06
Identities = 42/148 (28%), Positives = 67/148 (45%), Gaps = 10/148 (6%)
Query: 432 PMNTRRSSVGVGVVGGLLYAVGGYD--GASRQCLSTVECYNATTNEWTYIAEMSTR-RSG 488
P R S GV V + VGG G +++ L V C+N N+W +A + R
Sbjct: 572 PRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREF 628
Query: 489 AGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNM--CRRNAGVCAVNGLLY 546
V + +Y GG + + V Y + W V+ M + CR N+ V +G +Y
Sbjct: 629 FSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV--YDGKIY 686
Query: 547 VVGGDDGSCNLASVEYYNPTTDKWTVVS 574
+GG + N+ VE Y+ T++W V+
Sbjct: 687 TLGGLGVAGNVDHVERYDTITNQWEAVA 714
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 275 bits (703), Expect = 9e-74
Identities = 168/553 (30%), Positives = 275/553 (49%), Gaps = 21/553 (3%)
Query: 35 NPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSES-- 92
+P H ++ K +N+ R D+ IV E E H+ VLA+CS YF + + +S
Sbjct: 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQ 367
Query: 93 --RAK-RVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFL 149
R K + + + L +L+++VYT + + N + LL AA Q K C FL
Sbjct: 368 GGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Query: 150 ESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSD 209
E QL NCLG+ A A+ C++L + A +A Q F +V EE L++ + + +S+D
Sbjct: 428 EKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSND 487
Query: 210 KLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSS 269
L +EE V+E VI W+ D R ++ A L+ VRLP + YL+ V+ E L+K+S
Sbjct: 488 SLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSE 547
Query: 270 ACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQ-----APKAIRSVE 324
AC+D + EA +YH+LP R M++ RTR R + +++V+VGG+ +++ +V
Sbjct: 548 ACRDLVNEAKRYHMLP-HARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVT 606
Query: 325 CYDFKEERWHQVAELPSRRCRAGMVYMAG-LVFAVGGFNGSLRVRTVDSYDPVKDQWTSV 383
C++ + +W+ +A LP V AG ++ GG + + V Y + D W V
Sbjct: 607 CWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
Query: 384 ANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVG 443
+ M R + V +G +Y +GG + + VE Y+ +N+W VAP+ S
Sbjct: 667 SRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAAT 726
Query: 444 VVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG 503
V GG +Y GG + A R ++ Y TN W++I A LN ++ +GG
Sbjct: 727 VCGGKIYVFGGVNEAGR-AAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG 785
Query: 504 HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG---DDGSCNLASV 560
++ +YDP + +MN R+ ++G +Y GG +G L ++
Sbjct: 786 ----AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPA-LGNM 840
Query: 561 EYYNPTTDKWTVV 573
E Y PTT+ WT++
Sbjct: 841 EAYEPTTNTWTLL 853
Score = 50.1 bits (118), Expect = 6e-06
Identities = 42/148 (28%), Positives = 67/148 (45%), Gaps = 10/148 (6%)
Query: 432 PMNTRRSSVGVGVVGGLLYAVGGYD--GASRQCLSTVECYNATTNEWTYIAEMSTR-RSG 488
P R S GV V + VGG G +++ L V C+N N+W +A + R
Sbjct: 572 PRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREF 628
Query: 489 AGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNM--CRRNAGVCAVNGLLY 546
V + +Y GG + + V Y + W V+ M + CR N+ V +G +Y
Sbjct: 629 FSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV--YDGKIY 686
Query: 547 VVGGDDGSCNLASVEYYNPTTDKWTVVS 574
+GG + N+ VE Y+ T++W V+
Sbjct: 687 TLGGLGVAGNVDHVERYDTITNQWEAVA 714
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 262 bits (669), Expect = 7e-70
Identities = 173/558 (31%), Positives = 272/558 (48%), Gaps = 27/558 (4%)
Query: 27 EKHCPVTVNPW----HMKKAFKVMNELRSQNLLCDVTI-VAEDMEISAHRVVLAACSPYF 81
E+ P+ V P+ H + +++LR++ DVT+ A + AHR VLAA SPYF
Sbjct: 2 ERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYF 61
Query: 82 HAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDV 141
AMF G++ ESRA+RVR+ V L++L+D+ YT + V+ +N + LL AA LLQ V
Sbjct: 62 RAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAV 121
Query: 142 KKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQ 201
K+ C FL+ QL NCL ++ FA+ +C+ L + A + +H ++ +E+ L + +
Sbjct: 122 KEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELG-AEQLERLPLAR 180
Query: 202 VCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEE 261
+ + D L + EE ++ + WV D R +L+E VRLP + R YL+ VE
Sbjct: 181 LLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEA 240
Query: 262 EALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG--QAPKA 319
E LV C L EA + ++ R R R L +++V+VGG Q
Sbjct: 241 EPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDE 300
Query: 320 IRSVECYDFKEERWHQVAELPSRRCRA-GMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKD 378
+ +V+CY+ + +W +AE P +V + ++ GG +GS V Y+ +
Sbjct: 301 LVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVN 360
Query: 379 QWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRS 438
+W VA M R ++VL+GLLY V S E Y+ ++ W + PM
Sbjct: 361 EWAEVAPMLKAREYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMD 413
Query: 439 SVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYI--AEMSTRRSGAGVGVLNN 496
+ G LYA+G G ++CY+ T+ W+ + ++ LN
Sbjct: 414 NCSTTACRGRLYAIGSLAGKETM---VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNG 470
Query: 497 LLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN 556
L+Y V V+VY+PT N W ++ MN + + G LYV GG D +
Sbjct: 471 LMYFVRDDSA-----EVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFE 525
Query: 557 LAS-VEYYNPTTDKWTVV 573
L+ VE Y+P T W+VV
Sbjct: 526 LSDVVEAYDPETRAWSVV 543
Score = 43.9 bits (102), Expect = 4e-04
Identities = 31/99 (31%), Positives = 47/99 (47%), Gaps = 3/99 (3%)
Query: 494 LNNLLYAVGGHDGPLVRK-SVEVYDPTTNAWRQVADM-NMCRRNAGVCAVNGLLYVVGGD 551
L +L VGG D +V+ Y+P T WR +A+ + + A+ +YV GG
Sbjct: 284 LAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGS 343
Query: 552 DGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVID 590
DGS V YN + ++W V+ M R Y +V+D
Sbjct: 344 DGSRLYDCVWRYNSSVNEWAEVAP-MLKAREYHSSSVLD 381
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 261 bits (668), Expect = 1e-69
Identities = 167/553 (30%), Positives = 286/553 (51%), Gaps = 30/553 (5%)
Query: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDME--ISAHRVVLAACSPYFHAMFTGEMSESRAK 95
H + ++LR + LLCDVT++ D + HRV++A+ S YF AMFTG M E
Sbjct: 74 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM 133
Query: 96 RVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 155
+++ V LR +ID++YTA++ + +N+Q L AA LQ+ V C FL S +
Sbjct: 134 CIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTL 193
Query: 156 VNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISS 215
NC+ + A+ + T++ N++ ++F ++ + EFL L E++ ++SS+ L +
Sbjct: 194 DNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 253
Query: 216 EEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYL 275
E ++F+A W+ + + R +F A+LM+++R PL+ + L+ V+ ++ + C + L
Sbjct: 254 ELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 312
Query: 276 IEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG---QAPKAIRSVECYDFKEER 332
+EA Y ++P Q + M+S RT +R+ +V +GG Q + + YD K
Sbjct: 313 LEASNYQMMPYMQPV-MQSDRTAIRSDTT---HLVTLGGVLRQQLVVSKELRMYDEKAHE 368
Query: 333 WHQVAELPSRRCRAGMVYMAGLVFAVGG-----FNGSLRVRTVDSYDPVKDQWTSVANMR 387
W +A + + R + G+ + ++ VGG G V TV +DP ++W VA++
Sbjct: 369 WKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLN 428
Query: 388 DRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG 447
++R+ + L G LYAVGG + + L +VE YN ++NEW +VA M+ V GG
Sbjct: 429 EKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGG 488
Query: 448 LLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG---- 503
++Y GG + Q + C++ T++W A M+T R + + LY +GG
Sbjct: 489 VMYISGGITHDTFQ--KELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFR 546
Query: 504 ----HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD--DGSCNL 557
+D L S E Y P + W +A M + + GV +YVVGG + C +
Sbjct: 547 GTSDYDDVL---SCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 603
Query: 558 ASVEYYNPTTDKW 570
V+ Y+P D+W
Sbjct: 604 EIVQKYDPDKDEW 616
Score = 79.7 bits (195), Expect = 7e-15
Identities = 44/122 (36%), Positives = 61/122 (50%), Gaps = 5/122 (4%)
Query: 469 YNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-----GPLVRKSVEVYDPTTNAW 523
Y+ +EW +A M R G+ V+ N LY VGG G +V +DP N W
Sbjct: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421
Query: 524 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSY 583
QVA +N R + A+ G LY VGG + + L +VE YNP T++WT V+ +
Sbjct: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481
Query: 584 AG 585
AG
Sbjct: 482 AG 483
Score = 38.1 bits (87), Expect = 0.023
Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 2/81 (2%)
Query: 320 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGF--NGSLRVRTVDSYDPVK 377
+ S E Y ++W +A + + G+ ++ VGG+ N V V YDP K
Sbjct: 554 VLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDK 613
Query: 378 DQWTSVANMRDRRSTLGAAVL 398
D+W V ++ + + A L
Sbjct: 614 DEWHKVFDLPESLGGIRACTL 634
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 260 bits (664), Expect = 3e-69
Identities = 166/553 (30%), Positives = 287/553 (51%), Gaps = 30/553 (5%)
Query: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDME--ISAHRVVLAACSPYFHAMFTGEMSESRAK 95
H + ++LR + LLCDVT+V D + HR ++A+ S YF AMFTG M E
Sbjct: 32 HSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLM 91
Query: 96 RVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 155
+++ V+ L+ +ID++YTA++ + +N+Q L AA LQ+ V C FL S +
Sbjct: 92 CIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSL 151
Query: 156 VNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISS 215
NC+ + A+ + ++ N + ++F ++ + EFL L E++ ++SS+ L +
Sbjct: 152 DNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 211
Query: 216 EEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYL 275
E ++F+A W+ + D R ++ A+LM+++R PL+ + L+ V+ ++ + C + L
Sbjct: 212 ELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL 270
Query: 276 IEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG---QAPKAIRSVECYDFKEER 332
+EA Y ++P Q + M+S RT +R+ +V +GG Q + + YD + +
Sbjct: 271 LEASNYQMMPYMQPV-MQSDRTAIRSDST---HLVTLGGVLRQQLVVSKELRMYDERAQE 326
Query: 333 WHQVAELPSRRCRAGMVYMAGLVFAVGG-----FNGSLRVRTVDSYDPVKDQWTSVANMR 387
W +A + + R + G+ + ++ VGG G V TV +DP ++W VA++
Sbjct: 327 WRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLN 386
Query: 388 DRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG 447
++R+ + L G LYAVGG + L++VE YN + NEW +VA M+ V GG
Sbjct: 387 EKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGG 446
Query: 448 LLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG---- 503
L+Y GG + Q + + C++ T++W A M+T R + + + LY +GG
Sbjct: 447 LMYISGGITHDTFQ--NELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFR 504
Query: 504 ----HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD--DGSCNL 557
+D L S E Y PT + W +A M + + GV +YVVGG + C +
Sbjct: 505 GTSDYDDVL---SCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 561
Query: 558 ASVEYYNPTTDKW 570
V+ Y+P D+W
Sbjct: 562 EIVQKYDPEKDEW 574
Score = 76.3 bits (186), Expect = 8e-14
Identities = 43/122 (35%), Positives = 59/122 (48%), Gaps = 5/122 (4%)
Query: 469 YNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-----GPLVRKSVEVYDPTTNAW 523
Y+ EW +A M R G+ V+ N LY VGG G +V +DP N W
Sbjct: 320 YDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 379
Query: 524 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSY 583
QVA +N R + A+ G LY VGG + LA+VE YNP ++W+ V+ +
Sbjct: 380 MQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGH 439
Query: 584 AG 585
AG
Sbjct: 440 AG 441
Score = 39.3 bits (90), Expect = 0.010
Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 2/81 (2%)
Query: 320 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGF--NGSLRVRTVDSYDPVK 377
+ S E Y ++W +A + + G+ ++ VGG+ N V V YDP K
Sbjct: 512 VLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEK 571
Query: 378 DQWTSVANMRDRRSTLGAAVL 398
D+W V ++ + + A L
Sbjct: 572 DEWHKVFDLPESLGGIRACTL 592
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,533,916
Number of Sequences: 37866
Number of extensions: 910005
Number of successful extensions: 3494
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 171
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 1984
Number of HSP's gapped (non-prelim): 411
length of query: 593
length of database: 18,247,518
effective HSP length: 108
effective length of query: 485
effective length of database: 14,157,990
effective search space: 6866625150
effective search space used: 6866625150
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.