Search of human proteins with 119392086

Search of human proteins with 119392086

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|119392086 Indian hedgehog homolog [Homo sapiens]
         (411 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|119392086 Indian hedgehog homolog [Homo sapiens]                   842   0.0  
gi|4506939 sonic hedgehog preproprotein [Homo sapiens]                478   e-135
gi|19482158 desert hedgehog preproprotein [Homo sapiens]              452   e-127
gi|32698950 hypothetical protein LOC283870 [Homo sapiens]              35   0.12 
gi|4503375 dihydropyrimidinase [Homo sapiens]                          34   0.21 
gi|40255245 G protein-coupled receptor 51 [Homo sapiens]               31   1.8  
gi|149944548 neurobeachin-like 2 [Homo sapiens]                        30   3.0  
gi|59710113 Rho GTPase activating protein 28 isoform a [Homo sap...    30   5.2  
gi|33589824 cell growth regulator with EF-hand domain 1 [Homo sa...    30   5.2  
gi|59710111 Rho GTPase activating protein 28 isoform b [Homo sap...    30   5.2  
gi|211059433 coiled-coil domain containing 79 [Homo sapiens]           29   8.9  

>gi|119392086 Indian hedgehog homolog [Homo sapiens]
          Length = 411

 Score =  842 bits (2175), Expect = 0.0
 Identities = 411/411 (100%), Positives = 411/411 (100%)

Query: 1   MSPARLRPRLHFCLVLLLLLVVPAAWGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKT 60
           MSPARLRPRLHFCLVLLLLLVVPAAWGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKT
Sbjct: 1   MSPARLRPRLHFCLVLLLLLVVPAAWGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKT 60

Query: 61  LGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMN 120
           LGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMN
Sbjct: 61  LGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMN 120

Query: 121 QWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYY 180
           QWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYY
Sbjct: 121 QWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYY 180

Query: 181 ESKAHVHCSVKSEHSAAAKTGGCFPAGAQVRLESGARVALSAVRPGDRVLAMGEDGSPTF 240
           ESKAHVHCSVKSEHSAAAKTGGCFPAGAQVRLESGARVALSAVRPGDRVLAMGEDGSPTF
Sbjct: 181 ESKAHVHCSVKSEHSAAAKTGGCFPAGAQVRLESGARVALSAVRPGDRVLAMGEDGSPTF 240

Query: 241 SDVLIFLDREPHRLRAFQVIETQDPPRRLALTPAHLLFTADNHTEPAARFRATFASHVQP 300
           SDVLIFLDREPHRLRAFQVIETQDPPRRLALTPAHLLFTADNHTEPAARFRATFASHVQP
Sbjct: 241 SDVLIFLDREPHRLRAFQVIETQDPPRRLALTPAHLLFTADNHTEPAARFRATFASHVQP 300

Query: 301 GQYVLVAGVPGLQPARVAAVSTHVALGAYAPLTKHGTLVVEDVVASCFAAVADHHLAQLA 360
           GQYVLVAGVPGLQPARVAAVSTHVALGAYAPLTKHGTLVVEDVVASCFAAVADHHLAQLA
Sbjct: 301 GQYVLVAGVPGLQPARVAAVSTHVALGAYAPLTKHGTLVVEDVVASCFAAVADHHLAQLA 360

Query: 361 FWPLRLFHSLAWGSWTPGEGVHWYPQLLYRLGRLLLEEGSFHPLGMSGAGS 411
           FWPLRLFHSLAWGSWTPGEGVHWYPQLLYRLGRLLLEEGSFHPLGMSGAGS
Sbjct: 361 FWPLRLFHSLAWGSWTPGEGVHWYPQLLYRLGRLLLEEGSFHPLGMSGAGS 411


>gi|4506939 sonic hedgehog preproprotein [Homo sapiens]
          Length = 462

 Score =  478 bits (1231), Expect = e-135
 Identities = 262/453 (57%), Positives = 307/453 (67%), Gaps = 59/453 (13%)

Query: 13  CLVLLLL--LVVPAAWGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGK 70
           CL+L+L+  L+V +   CGPGR  G RR P +KL PLAYKQF PNV EKTLGASGRYEGK
Sbjct: 7   CLLLVLVSSLLVCSGLACGPGRGFGKRRHP-KKLTPLAYKQFIPNVAEKTLGASGRYEGK 65

Query: 71  IARSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVT 130
           I+R+SERFKELTPNYNPDIIFKDEENTGADRLMTQRCKD+LN+LAISVMNQWPGVKLRVT
Sbjct: 66  ISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVT 125

Query: 131 EGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSV 190
           EGWDEDGHHSEESLHYEGRAVDITTSDRDR+KYG+LARLAVEAGFDWVYYESKAH+HCSV
Sbjct: 126 EGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSV 185

Query: 191 KSEHSAAAKTGGCFPAGAQVRLESGARVALSAVRPGDRVLAMGEDGSPTFSDVLIFLDRE 250
           K+E+S AAK+GGCFP  A V LE G    +  + PGDRVLA  + G   +SD L FLDR+
Sbjct: 186 KAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRD 245

Query: 251 PHRLRAFQVIETQDPPRRLALTPAHLLFTADNHT----EPAARF------------RATF 294
               + F VIET++P  RL LT AHLLF A ++     EP A              RA F
Sbjct: 246 DGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGPPSGGALGPRALF 305

Query: 295 ASHVQPGQYVLVA----GVPGLQPARVAAVS-THVALGAYAPLTKHGTLVVEDVVASCFA 349
           AS V+PGQ V V     G   L PA V +V+ +  A GAYAPLT  GT+++  V+ASC+A
Sbjct: 306 ASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVLASCYA 365

Query: 350 AVADHHLAQLAFWPLRLFHSL-------------------------------AWGSWTPG 378
            + +H  A  AF P RL H+L                                  +  PG
Sbjct: 366 VIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTAPGAADAPG 425

Query: 379 ----EGVHWYPQLLYRLGRLLLEEGSFHPLGMS 407
                G+HWY QLLY++G  LL+  + HPLGM+
Sbjct: 426 AGATAGIHWYSQLLYQIGTWLLDSEALHPLGMA 458


>gi|19482158 desert hedgehog preproprotein [Homo sapiens]
          Length = 396

 Score =  452 bits (1163), Expect = e-127
 Identities = 233/389 (59%), Positives = 280/389 (71%), Gaps = 9/389 (2%)

Query: 14  LVLLLLLVVPAAWGCGPGR-VVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIA 72
           L  L LL +PA   CGPGR  VG RR   ++LVPL YKQF P VPE+TLGASG  EG++A
Sbjct: 10  LCCLALLALPAQ-SCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGASGPAEGRVA 68

Query: 73  RSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEG 132
           R SERF++L PNYNPDIIFKDEEN+GADRLMT+RCK+R+N+LAI+VMN WPGV+LRVTEG
Sbjct: 69  RGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEG 128

Query: 133 WDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKS 192
           WDEDGHH+++SLHYEGRA+DITTSDRDRNKYGLLARLAVEAGFDWVYYES+ HVH SVK+
Sbjct: 129 WDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKA 188

Query: 193 EHSAAAKTGGCFPAGAQVRLESGARVALSAVRPGDRVLAMGEDGSPTFSDVLIFLDREPH 252
           ++S A + GGCFP  A VRL SG R  L  +  GD VLA    G    + VL+FLDR+  
Sbjct: 189 DNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDRDLQ 248

Query: 253 RLRAFQVIETQDPPRRLALTPAHLLFTADNHTEPAARFRATFASHVQPGQYVLVAGVPGL 312
           R  +F  +ET+ PPR+L LTP HL+F A         F   FA  ++ G  VL  G   L
Sbjct: 249 RRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDAL 308

Query: 313 QPARVAAVSTHVALGAYAPLTKHGTLVVEDVVASCFAAVADHHLAQLAFWPLRLFHSLAW 372
           +PARVA V+   A+G +APLT HGTL+V DV+ASC+A +  H  A  AF PLRL H+L  
Sbjct: 309 RPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHAL-- 366

Query: 373 GSWTPG-----EGVHWYPQLLYRLGRLLL 396
           G+  PG      G+HWY +LLYRL   LL
Sbjct: 367 GALLPGGAVQPTGMHWYSRLLYRLAEELL 395


>gi|32698950 hypothetical protein LOC283870 [Homo sapiens]
          Length = 228

 Score = 35.0 bits (79), Expect = 0.12
 Identities = 42/146 (28%), Positives = 67/146 (45%), Gaps = 20/146 (13%)

Query: 14  LVLLLLLVVPAAWGCGPGRVVGSRRRPPR-KLVPLAYKQFSPNVP---EKTLGASGRYEG 69
           L+LLLLL+V AA G   G ++GS + PP+ +L  L     SP++P   +  L    R   
Sbjct: 32  LLLLLLLLVLAAVGIVAGGLLGSAQGPPKPRLQTLRMTLPSPHMPRPNQTILVDVARNAA 91

Query: 70  KIA----RSSERFKELTPNYNPDIIFKDEENTGAD-RLMTQRCKDRLNSLAISVMNQWPG 124
            I     +S+  +  L    +  I ++ EE+     RLM    ++ L  L  +       
Sbjct: 92  TITVTPPQSNHSWAVLFDGQSGCICYRPEEHQVCFLRLMEDSDRETLRLLVDT------- 144

Query: 125 VKLRVTEGW--DEDGHHSEESLHYEG 148
              +V E W   +D HH++E L  +G
Sbjct: 145 --SKVQEAWVPSQDTHHTQELLAVQG 168


>gi|4503375 dihydropyrimidinase [Homo sapiens]
          Length = 519

 Score = 34.3 bits (77), Expect = 0.21
 Identities = 30/119 (25%), Positives = 55/119 (46%), Gaps = 7/119 (5%)

Query: 82  TPNYNPDIIFKDE-ENTGADRLMTQRCKDRLNSLAIS-VMNQWPGVKLRVTEGWDEDGHH 139
           TP++  +++  D+   TG D      C+  L     + + N   GV+ R++  W++  H 
Sbjct: 307 TPDFLMNLLANDDLTTTGTDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIWEKGVHS 366

Query: 140 SEESLHYEGRAVDITTSDRDR--NKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSA 196
            +     E R V +T+++  +  N Y    R+AV +  D V ++ K     S K+ H A
Sbjct: 367 GKMD---ENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDPKGTRTISAKTHHQA 422


>gi|40255245 G protein-coupled receptor 51 [Homo sapiens]
          Length = 941

 Score = 31.2 bits (69), Expect = 1.8
 Identities = 24/64 (37%), Positives = 28/64 (43%), Gaps = 8/64 (12%)

Query: 3  PARLRPRLHFCLVLLLLLVVPAAWGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLG 62
          PARL   L   L+ LLL + P AWG   G       RPP    PL+     P   E   G
Sbjct: 20 PARL---LLLLLLPLLLPLAPGAWGWARG-----APRPPPSSPPLSIMGLMPLTKEVAKG 71

Query: 63 ASGR 66
          + GR
Sbjct: 72 SIGR 75


>gi|149944548 neurobeachin-like 2 [Homo sapiens]
          Length = 2754

 Score = 30.4 bits (67), Expect = 3.0
 Identities = 36/149 (24%), Positives = 56/149 (37%), Gaps = 13/149 (8%)

Query: 258  QVIETQDPPRRLALTPAHLLFTADNHT----EPAARFRATFASHVQPGQYVLVAGVPGLQ 313
            Q+++   P R  A   AH L   D ++    +     +A FA  V  G  +++A VP  Q
Sbjct: 2336 QLLKEPHPTRLSAEEAAHRLARLDTNSPSIFQHLDELKAFFAEVVSDGVPLVLALVPHRQ 2395

Query: 314  PARVAAVSTH---VALGAYAPLTKHGTLVVEDVVASCFAAVADHHLAQLAFWPLRLFHSL 370
            P       +    V + A   L  H  L  +  +++ F+   D  +             L
Sbjct: 2396 PHSFITQGSPDLLVTVSASGLLGTHSWLPYDRNISNYFSFSKDPTMGS------HKTQRL 2449

Query: 371  AWGSWTPGEGVHWYPQLLYRLGRLLLEEG 399
              G W PG GV      +   G+LL   G
Sbjct: 2450 LSGPWVPGSGVSGQALAVAPDGKLLFSGG 2478


>gi|59710113 Rho GTPase activating protein 28 isoform a [Homo
           sapiens]
          Length = 570

 Score = 29.6 bits (65), Expect = 5.2
 Identities = 18/56 (32%), Positives = 27/56 (48%), Gaps = 2/56 (3%)

Query: 35  GSRRRPPRKLVPLAYKQFSPNVPEKTLGASG--RYEGKIARSSERFKELTPNYNPD 88
           G R++ P   VPL  ++F   V E  L + G  R  G  A+  +  +EL   +N D
Sbjct: 229 GDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNAD 284


>gi|33589824 cell growth regulator with EF-hand domain 1 [Homo
           sapiens]
          Length = 301

 Score = 29.6 bits (65), Expect = 5.2
 Identities = 25/90 (27%), Positives = 37/90 (41%), Gaps = 20/90 (22%)

Query: 213 ESGARVALSAVRPGDRVLAMGEDGSPTFSDVLIFLDREPHRLRAFQVIETQDPPRRLALT 272
           +SG    L  +      LA G   SPT + V++ +D+         V+ETQD      +T
Sbjct: 85  QSGQLDGLELLSMLTAALAPGAANSPTTNPVILIVDK---------VLETQDLNGDGLMT 135

Query: 273 PAHLLFTADNHTEPAARFRATFASHVQPGQ 302
           PA L+            F      HV+PG+
Sbjct: 136 PAELI-----------NFPGVALRHVEPGE 154


>gi|59710111 Rho GTPase activating protein 28 isoform b [Homo
           sapiens]
          Length = 563

 Score = 29.6 bits (65), Expect = 5.2
 Identities = 18/56 (32%), Positives = 27/56 (48%), Gaps = 2/56 (3%)

Query: 35  GSRRRPPRKLVPLAYKQFSPNVPEKTLGASG--RYEGKIARSSERFKELTPNYNPD 88
           G R++ P   VPL  ++F   V E  L + G  R  G  A+  +  +EL   +N D
Sbjct: 229 GDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNAD 284


>gi|211059433 coiled-coil domain containing 79 [Homo sapiens]
          Length = 727

 Score = 28.9 bits (63), Expect = 8.9
 Identities = 15/62 (24%), Positives = 28/62 (45%), Gaps = 4/62 (6%)

Query: 94  EENTGADRLMTQRCKDRLNSLAISVMNQWPGVKL----RVTEGWDEDGHHSEESLHYEGR 149
           E     + +  +  +D ++S+ IS+ N W  +      R ++  DED  HS +   Y+  
Sbjct: 419 EREGNEEEIQRENYQDNISSMNISIQNTWKHLHADRIGRGSKAEDEDKSHSRQLQSYKSH 478

Query: 150 AV 151
            V
Sbjct: 479 GV 480


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,180,065
Number of Sequences: 37866
Number of extensions: 805939
Number of successful extensions: 1760
Number of sequences better than 10.0: 11
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1749
Number of HSP's gapped (non-prelim): 12
length of query: 411
length of database: 18,247,518
effective HSP length: 105
effective length of query: 306
effective length of database: 14,271,588
effective search space: 4367105928
effective search space used: 4367105928
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.