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Search of human proteins with 116536089
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]
(575 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens] 1147 0.0
gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens] 1147 0.0
gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens] 1147 0.0
gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens] 981 0.0
gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens] 455 e-128
gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens] 455 e-128
gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens] 455 e-128
gi|157364939 phosphodiesterase 6C [Homo sapiens] 350 3e-96
gi|170650674 phosphodiesterase 6A [Homo sapiens] 349 3e-96
gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens] 347 2e-95
gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens] 347 2e-95
gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens] 341 9e-94
gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens] 341 9e-94
gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens] 326 3e-89
gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens] 320 3e-87
gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens] 320 3e-87
gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens] 320 3e-87
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 159 9e-39
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 159 9e-39
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 159 9e-39
gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens] 159 9e-39
gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens] 159 9e-39
gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens] 159 9e-39
gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens] 159 9e-39
gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens] 159 9e-39
gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens] 159 9e-39
gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens] 159 9e-39
gi|48762734 phosphodiesterase 9A isoform i [Homo sapiens] 159 9e-39
gi|48762732 phosphodiesterase 9A isoform h [Homo sapiens] 159 9e-39
gi|48762730 phosphodiesterase 9A isoform g [Homo sapiens] 159 9e-39
>gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]
Length = 575
Score = 1147 bits (2966), Expect = 0.0
Identities = 575/575 (100%), Positives = 575/575 (100%)
Query: 1 MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLL 60
MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLL
Sbjct: 1 MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLL 60
Query: 61 KCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL 120
KCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL
Sbjct: 61 KCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL 120
Query: 121 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 180
VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP
Sbjct: 121 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 180
Query: 181 FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA 240
FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA
Sbjct: 181 FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA 240
Query: 241 NIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY 300
NIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY
Sbjct: 241 NIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY 300
Query: 301 RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAK 360
RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAK
Sbjct: 301 RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAK 360
Query: 361 SGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLT 420
SGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLT
Sbjct: 361 SGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLT 420
Query: 421 LYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEF 480
LYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEF
Sbjct: 421 LYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEF 480
Query: 481 FEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSV 540
FEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSV
Sbjct: 481 FEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSV 540
Query: 541 ATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN 575
ATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN
Sbjct: 541 ATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN 575
>gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]
Length = 683
Score = 1147 bits (2966), Expect = 0.0
Identities = 575/575 (100%), Positives = 575/575 (100%)
Query: 1 MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLL 60
MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLL
Sbjct: 109 MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLL 168
Query: 61 KCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL 120
KCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL
Sbjct: 169 KCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL 228
Query: 121 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 180
VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP
Sbjct: 229 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 288
Query: 181 FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA 240
FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA
Sbjct: 289 FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA 348
Query: 241 NIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY 300
NIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY
Sbjct: 349 NIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY 408
Query: 301 RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAK 360
RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAK
Sbjct: 409 RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAK 468
Query: 361 SGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLT 420
SGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLT
Sbjct: 469 SGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLT 528
Query: 421 LYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEF 480
LYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEF
Sbjct: 529 LYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEF 588
Query: 481 FEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSV 540
FEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSV
Sbjct: 589 FEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSV 648
Query: 541 ATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN 575
ATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN
Sbjct: 649 ATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN 683
Score = 74.3 bits (181), Expect = 3e-13
Identities = 31/91 (34%), Positives = 64/91 (70%), Gaps = 1/91 (1%)
Query: 135 QDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL-DGKPFDDADQRLFEAFV 193
+D RF+ E D+++G+ +S+LC+PI +S+ +IIGVAQ +N++ +G PF + D+++ + ++
Sbjct: 54 KDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYL 113
Query: 194 IFCGLGINNTIMYDQVKKSWAKQSVALDVLS 224
FCG+ I+N ++ +K + + L+V++
Sbjct: 114 PFCGIAISNAQLFAASRKEYERSRALLEVVN 144
>gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]
Length = 933
Score = 1147 bits (2966), Expect = 0.0
Identities = 575/575 (100%), Positives = 575/575 (100%)
Query: 1 MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLL 60
MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLL
Sbjct: 359 MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLL 418
Query: 61 KCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL 120
KCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL
Sbjct: 419 KCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL 478
Query: 121 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 180
VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP
Sbjct: 479 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 538
Query: 181 FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA 240
FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA
Sbjct: 539 FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA 598
Query: 241 NIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY 300
NIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY
Sbjct: 599 NIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY 658
Query: 301 RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAK 360
RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAK
Sbjct: 659 RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAK 718
Query: 361 SGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLT 420
SGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLT
Sbjct: 719 SGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLT 778
Query: 421 LYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEF 480
LYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEF
Sbjct: 779 LYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEF 838
Query: 481 FEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSV 540
FEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSV
Sbjct: 839 FEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSV 898
Query: 541 ATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN 575
ATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN
Sbjct: 899 ATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN 933
Score = 98.2 bits (243), Expect = 2e-20
Identities = 63/208 (30%), Positives = 116/208 (55%), Gaps = 16/208 (7%)
Query: 23 KEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIES-PVVKFT 81
K++ + LE+V D+ + DL + KI+ ++ +RCS+ L+E + +
Sbjct: 197 KKHNERQFFLELVKDISND-LDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVS 255
Query: 82 KSFELMSPK----CSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDP 137
K F++ + CS+ ENS + + W I V G VNI DAYQD
Sbjct: 256 KFFDVHAGTPLLPCSS-TENSNEVQVP------W--GKGIIGYVGEHGETVNIPDAYQDR 306
Query: 138 RFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL-DGKPFDDADQRLFEAFVIFC 196
RF+ E D+++G+ +S+LC+PI +S+ +IIGVAQ +N++ +G PF + D+++ + ++ FC
Sbjct: 307 RFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFC 366
Query: 197 GLGINNTIMYDQVKKSWAKQSVALDVLS 224
G+ I+N ++ +K + + L+V++
Sbjct: 367 GIAISNAQLFAASRKEYERSRALLEVVN 394
>gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]
Length = 489
Score = 981 bits (2537), Expect = 0.0
Identities = 489/489 (100%), Positives = 489/489 (100%)
Query: 87 MSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI 146
MSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI
Sbjct: 1 MSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI 60
Query: 147 SGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMY 206
SGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMY
Sbjct: 61 SGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMY 120
Query: 207 DQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMI 266
DQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMI
Sbjct: 121 DQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMI 180
Query: 267 TAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAG 326
TAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAG
Sbjct: 181 TAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAG 240
Query: 327 FQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMI 386
FQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMI
Sbjct: 241 FQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMI 300
Query: 387 LQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHR 446
LQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHR
Sbjct: 301 LQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHR 360
Query: 447 DIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDE 506
DIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDE
Sbjct: 361 DIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDE 420
Query: 507 LPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPAS 566
LPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPAS
Sbjct: 421 LPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPAS 480
Query: 567 VMVAKEDRN 575
VMVAKEDRN
Sbjct: 481 VMVAKEDRN 489
>gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]
Length = 875
Score = 455 bits (1170), Expect = e-128
Identities = 239/564 (42%), Positives = 360/564 (63%), Gaps = 22/564 (3%)
Query: 4 YLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCE 63
YL FCGI + NAQL+ S E +R++ LL++ + +FEEQ LE I+KKI + ++ +
Sbjct: 306 YLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQ 365
Query: 64 RCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVAS 123
+C++ ++++ S F+ F + + ++ +E IN A+ V +
Sbjct: 366 KCTIFIVDEDCSD--SFSSVFHMECEELEKSSDTLTREHDANK------INYMYAQYVKN 417
Query: 124 TGLPVNISDAYQDPRFDAEADQISGFH---IRSVLCVPIWNSN-HQIIGVAQVLNRLDG- 178
T P+NI D +D RF + + IRS+LC PI N +++IGV Q++N+++
Sbjct: 418 TMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEN 477
Query: 179 ----KPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEV 234
KPF+ D++ EAFVIFCGLGI NT MY+ V+++ AKQ V L+VLSYHA+ ++ E
Sbjct: 478 TGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEET 537
Query: 235 DKFK---AANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCR 291
+ + AA +P L I D F DF L +RMF +L +VQ F++ +E LCR
Sbjct: 538 RELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCR 597
Query: 292 WLLTVRKNYRM-VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDH 350
W+L+V+KNYR V YHNWRHAFN Q MFA L Q+ LT++EILA+++ L HDLDH
Sbjct: 598 WILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDH 657
Query: 351 RGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLL 410
RG NN++ +S LAQLY S +EHHHF+ +MIL S G+ I + LS +EY ++++
Sbjct: 658 RGVNNSYIQRSEHPLAQLYCHSI-MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKII 716
Query: 411 KQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISR 470
KQ+ILATDL LY +RR EFFEL+ K +++ + +++F +MLMTACDL A+TKPW I +
Sbjct: 717 KQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQ 776
Query: 471 QVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVN 530
++AELV +EFF+QGDRER EL + P+ + +R +K+++P +Q+ +ID+IC+ LY+AL V+
Sbjct: 777 RIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVS 836
Query: 531 VKLKPMLDSVATNRSKWEELHQKR 554
P+LD NR KW+ L +++
Sbjct: 837 EDCFPLLDGCRKNRQKWQALAEQQ 860
Score = 107 bits (268), Expect = 2e-23
Identities = 67/205 (32%), Positives = 111/205 (54%), Gaps = 15/205 (7%)
Query: 24 EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLL-EDIESPVVKFTK 82
E ++ LLE+V D+ D+ + KI L+ +R S+ L+ ED + ++
Sbjct: 145 EGDQCSRLLELVKDI-SSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISR 203
Query: 83 SFELMSPKCSADAENSFKESMEKSSYS-DWLINNSIAELVASTGLPVNISDAYQDPRFDA 141
F++ AE S E + + +W N I VA+ G P+NI DAY+DPRF+A
Sbjct: 204 LFDV--------AEGSTLEEVSNNCIRLEW--NKGIVGHVAALGEPLNIKDAYEDPRFNA 253
Query: 142 EADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK--PFDDADQRLFEAFVIFCGLG 199
E DQI+G+ +S+LC+PI N +++GVAQ +N+ G F + D++ F A++ FCG+
Sbjct: 254 EVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIV 313
Query: 200 INNTIMYDQVKKSWAKQSVALDVLS 224
++N +Y+ + V LD+ S
Sbjct: 314 LHNAQLYETSLLENKRNQVLLDLAS 338
Score = 34.3 bits (77), Expect = 0.32
Identities = 18/63 (28%), Positives = 35/63 (55%), Gaps = 4/63 (6%)
Query: 1 MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVN---DLFEEQT-DLEKIVKKIMHRA 56
++ ++ FCG+ I N Q++ A + + LEV++ EE+T +L+ + ++ A
Sbjct: 492 LEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSA 551
Query: 57 QTL 59
QTL
Sbjct: 552 QTL 554
>gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]
Length = 823
Score = 455 bits (1170), Expect = e-128
Identities = 239/564 (42%), Positives = 360/564 (63%), Gaps = 22/564 (3%)
Query: 4 YLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCE 63
YL FCGI + NAQL+ S E +R++ LL++ + +FEEQ LE I+KKI + ++ +
Sbjct: 254 YLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQ 313
Query: 64 RCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVAS 123
+C++ ++++ S F+ F + + ++ +E IN A+ V +
Sbjct: 314 KCTIFIVDEDCSD--SFSSVFHMECEELEKSSDTLTREHDANK------INYMYAQYVKN 365
Query: 124 TGLPVNISDAYQDPRFDAEADQISGFH---IRSVLCVPIWNSN-HQIIGVAQVLNRLDG- 178
T P+NI D +D RF + + IRS+LC PI N +++IGV Q++N+++
Sbjct: 366 TMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEN 425
Query: 179 ----KPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEV 234
KPF+ D++ EAFVIFCGLGI NT MY+ V+++ AKQ V L+VLSYHA+ ++ E
Sbjct: 426 TGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEET 485
Query: 235 DKFK---AANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCR 291
+ + AA +P L I D F DF L +RMF +L +VQ F++ +E LCR
Sbjct: 486 RELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCR 545
Query: 292 WLLTVRKNYRM-VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDH 350
W+L+V+KNYR V YHNWRHAFN Q MFA L Q+ LT++EILA+++ L HDLDH
Sbjct: 546 WILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDH 605
Query: 351 RGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLL 410
RG NN++ +S LAQLY S +EHHHF+ +MIL S G+ I + LS +EY ++++
Sbjct: 606 RGVNNSYIQRSEHPLAQLYCHSI-MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKII 664
Query: 411 KQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISR 470
KQ+ILATDL LY +RR EFFEL+ K +++ + +++F +MLMTACDL A+TKPW I +
Sbjct: 665 KQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQ 724
Query: 471 QVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVN 530
++AELV +EFF+QGDRER EL + P+ + +R +K+++P +Q+ +ID+IC+ LY+AL V+
Sbjct: 725 RIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVS 784
Query: 531 VKLKPMLDSVATNRSKWEELHQKR 554
P+LD NR KW+ L +++
Sbjct: 785 EDCFPLLDGCRKNRQKWQALAEQQ 808
Score = 107 bits (268), Expect = 2e-23
Identities = 67/205 (32%), Positives = 111/205 (54%), Gaps = 15/205 (7%)
Query: 24 EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLL-EDIESPVVKFTK 82
E ++ LLE+V D+ D+ + KI L+ +R S+ L+ ED + ++
Sbjct: 93 EGDQCSRLLELVKDI-SSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISR 151
Query: 83 SFELMSPKCSADAENSFKESMEKSSYS-DWLINNSIAELVASTGLPVNISDAYQDPRFDA 141
F++ AE S E + + +W N I VA+ G P+NI DAY+DPRF+A
Sbjct: 152 LFDV--------AEGSTLEEVSNNCIRLEW--NKGIVGHVAALGEPLNIKDAYEDPRFNA 201
Query: 142 EADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK--PFDDADQRLFEAFVIFCGLG 199
E DQI+G+ +S+LC+PI N +++GVAQ +N+ G F + D++ F A++ FCG+
Sbjct: 202 EVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIV 261
Query: 200 INNTIMYDQVKKSWAKQSVALDVLS 224
++N +Y+ + V LD+ S
Sbjct: 262 LHNAQLYETSLLENKRNQVLLDLAS 286
Score = 34.3 bits (77), Expect = 0.32
Identities = 18/63 (28%), Positives = 35/63 (55%), Gaps = 4/63 (6%)
Query: 1 MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVN---DLFEEQT-DLEKIVKKIMHRA 56
++ ++ FCG+ I N Q++ A + + LEV++ EE+T +L+ + ++ A
Sbjct: 440 LEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSA 499
Query: 57 QTL 59
QTL
Sbjct: 500 QTL 502
>gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]
Length = 833
Score = 455 bits (1170), Expect = e-128
Identities = 239/564 (42%), Positives = 360/564 (63%), Gaps = 22/564 (3%)
Query: 4 YLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCE 63
YL FCGI + NAQL+ S E +R++ LL++ + +FEEQ LE I+KKI + ++ +
Sbjct: 264 YLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQ 323
Query: 64 RCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVAS 123
+C++ ++++ S F+ F + + ++ +E IN A+ V +
Sbjct: 324 KCTIFIVDEDCSD--SFSSVFHMECEELEKSSDTLTREHDANK------INYMYAQYVKN 375
Query: 124 TGLPVNISDAYQDPRFDAEADQISGFH---IRSVLCVPIWNSN-HQIIGVAQVLNRLDG- 178
T P+NI D +D RF + + IRS+LC PI N +++IGV Q++N+++
Sbjct: 376 TMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEN 435
Query: 179 ----KPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEV 234
KPF+ D++ EAFVIFCGLGI NT MY+ V+++ AKQ V L+VLSYHA+ ++ E
Sbjct: 436 TGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEET 495
Query: 235 DKFK---AANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCR 291
+ + AA +P L I D F DF L +RMF +L +VQ F++ +E LCR
Sbjct: 496 RELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCR 555
Query: 292 WLLTVRKNYRM-VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDH 350
W+L+V+KNYR V YHNWRHAFN Q MFA L Q+ LT++EILA+++ L HDLDH
Sbjct: 556 WILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDH 615
Query: 351 RGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLL 410
RG NN++ +S LAQLY S +EHHHF+ +MIL S G+ I + LS +EY ++++
Sbjct: 616 RGVNNSYIQRSEHPLAQLYCHSI-MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKII 674
Query: 411 KQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISR 470
KQ+ILATDL LY +RR EFFEL+ K +++ + +++F +MLMTACDL A+TKPW I +
Sbjct: 675 KQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQ 734
Query: 471 QVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVN 530
++AELV +EFF+QGDRER EL + P+ + +R +K+++P +Q+ +ID+IC+ LY+AL V+
Sbjct: 735 RIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVS 794
Query: 531 VKLKPMLDSVATNRSKWEELHQKR 554
P+LD NR KW+ L +++
Sbjct: 795 EDCFPLLDGCRKNRQKWQALAEQQ 818
Score = 107 bits (268), Expect = 2e-23
Identities = 67/205 (32%), Positives = 111/205 (54%), Gaps = 15/205 (7%)
Query: 24 EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLL-EDIESPVVKFTK 82
E ++ LLE+V D+ D+ + KI L+ +R S+ L+ ED + ++
Sbjct: 103 EGDQCSRLLELVKDI-SSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISR 161
Query: 83 SFELMSPKCSADAENSFKESMEKSSYS-DWLINNSIAELVASTGLPVNISDAYQDPRFDA 141
F++ AE S E + + +W N I VA+ G P+NI DAY+DPRF+A
Sbjct: 162 LFDV--------AEGSTLEEVSNNCIRLEW--NKGIVGHVAALGEPLNIKDAYEDPRFNA 211
Query: 142 EADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK--PFDDADQRLFEAFVIFCGLG 199
E DQI+G+ +S+LC+PI N +++GVAQ +N+ G F + D++ F A++ FCG+
Sbjct: 212 EVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIV 271
Query: 200 INNTIMYDQVKKSWAKQSVALDVLS 224
++N +Y+ + V LD+ S
Sbjct: 272 LHNAQLYETSLLENKRNQVLLDLAS 296
Score = 34.3 bits (77), Expect = 0.32
Identities = 18/63 (28%), Positives = 35/63 (55%), Gaps = 4/63 (6%)
Query: 1 MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVN---DLFEEQT-DLEKIVKKIMHRA 56
++ ++ FCG+ I N Q++ A + + LEV++ EE+T +L+ + ++ A
Sbjct: 450 LEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSA 509
Query: 57 QTL 59
QTL
Sbjct: 510 QTL 512
>gi|157364939 phosphodiesterase 6C [Homo sapiens]
Length = 858
Score = 350 bits (897), Expect = 3e-96
Identities = 203/601 (33%), Positives = 316/601 (52%), Gaps = 55/601 (9%)
Query: 4 YLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCE 63
YL F I + E RS+ L+ N +FEE TD+E+ K ++ ++ L CE
Sbjct: 216 YLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCE 275
Query: 64 RCSVLLL------EDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSD------- 110
R S+ LL E + +K + PK E +F + ++ +
Sbjct: 276 RYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIP 335
Query: 111 ------WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNS 162
W + + + VA G N+ +A D F + + +G+ I++VL +PI N
Sbjct: 336 TPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNK 395
Query: 163 NHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDV 222
I+GVA NR DGKPFD+ D+ + E F G + NT YD++ K ++ +A ++
Sbjct: 396 KEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEM 455
Query: 223 LSYHATCSKAEVDKF----KAANIPLVSELA-------------------IDDIHFDDFS 259
L + E+ + N+ ++ + + + F DF
Sbjct: 456 LMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFP 515
Query: 260 LDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMF 319
L +I +R+F E+ +V+KFK+ E L RW+ TVRK YR V YHNWRH FNV Q MF
Sbjct: 516 LTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMF 575
Query: 320 AMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHH 379
+L T + T++E A++ CHD+DHRGTNN +Q KS S LA+L+G S+ LE HH
Sbjct: 576 TLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHG-SSILERHH 634
Query: 380 FNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGE-- 437
++ +LQ E NIF NL+ +++ ++ L + +I+ATDL LYF++RT F ++V E
Sbjct: 635 LEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQM 694
Query: 438 --------YDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERL 489
Y ++I +M+MTACDL A+TKPWE+ QVA +V +EF+EQGD ER
Sbjct: 695 QTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERT 754
Query: 490 ELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEE 549
L+ P + DRN++DELP+LQ+ +ID +C +Y+ + + ++ PML + NR +W+
Sbjct: 755 VLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKS 814
Query: 550 L 550
L
Sbjct: 815 L 815
>gi|170650674 phosphodiesterase 6A [Homo sapiens]
Length = 860
Score = 349 bits (896), Expect = 3e-96
Identities = 201/605 (33%), Positives = 318/605 (52%), Gaps = 64/605 (10%)
Query: 4 YLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCE 63
YL F + + L E R + LL + +FEE TD+E+ K ++ + L C+
Sbjct: 214 YLNFANLIMKVYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCD 273
Query: 64 RCSVLLLEDIESPVVKFTKSFELM-----------SPKCSADAENSFKESMEKSSYSD-- 110
R SV LL+ + K + F++ P+ E +F + ++ +
Sbjct: 274 RYSVGLLD-----MTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKED 328
Query: 111 -----------WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCV 157
W + + + VA GL NI +A + F + + + SG+ I++VL +
Sbjct: 329 IKVIPNPPPDHWALVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSM 388
Query: 158 PIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQS 217
PI N +I+GVA NR DGKPFD+ D+ L E+ F G + N Y+ + K ++
Sbjct: 389 PIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKD 448
Query: 218 VALDVLSYHATCSKAEVDKFKA----------------------ANIPLVSELAIDDIHF 255
+ D++ YH C E+ K A +P + I+ HF
Sbjct: 449 IFQDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHF 508
Query: 256 DDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVC 315
D L ++ ++M+ EL +V KF I E L R++ ++ K YR + YHNWRH FNV
Sbjct: 509 SDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVG 568
Query: 316 QLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATL 375
Q MF++L T + T++E LA++ CHD+DHRGTNN +Q KS + LA+L+G S+ L
Sbjct: 569 QTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHG-SSIL 627
Query: 376 EHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS- 434
E HH +L+ E NIF NL+ +++ + ++ +I+ATDL LYF++RT F ++V
Sbjct: 628 ERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQ 687
Query: 435 ----KGEYDWN-----IKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGD 485
+ E +W + ++I +M+MTACDL A+TKPWE+ QVA LV +EF+EQGD
Sbjct: 688 SKTYESEQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGD 747
Query: 486 RERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRS 545
ER L+ P + DRN+ DELP+LQ+ +ID +C +Y+ + + ++ PMLD + NR
Sbjct: 748 LERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRK 807
Query: 546 KWEEL 550
+W+ L
Sbjct: 808 EWKAL 812
>gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]
Length = 853
Score = 347 bits (889), Expect = 2e-95
Identities = 206/602 (34%), Positives = 315/602 (52%), Gaps = 58/602 (9%)
Query: 4 YLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCE 63
YL F + + L E R + LL N +FEE TD+E+ K + + L CE
Sbjct: 212 YLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCE 271
Query: 64 RCSVLLLE--------DIESPVVKFTKSFELMSPKCSADAENSF----------KESME- 104
R SV LL+ D+ S ++ ++ + P+ E F KE ++
Sbjct: 272 RYSVGLLDMTKEKEFFDVWSVLMGESQPYS--GPRTPDGREIVFYKVIDYILHGKEEIKV 329
Query: 105 --KSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIW 160
S W + + + VA +G NI +A D F + + SG+ I++VL +PI
Sbjct: 330 IPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIV 389
Query: 161 NSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVAL 220
N +I+GVA NR DGKPFD+ D+ L E+ F G + NT YD++ K ++ +A
Sbjct: 390 NKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQ 449
Query: 221 DVLSYHATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDF 258
D++ YH C + E+ L E A I + HF D
Sbjct: 450 DMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDL 509
Query: 259 SLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLM 318
++ ++M+ ELG+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q M
Sbjct: 510 ECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTM 569
Query: 319 FAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHH 378
F +L T + T++E A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE H
Sbjct: 570 FTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERH 628
Query: 379 HFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG-- 436
H +L E NI+ NL+ +++ ++ L+ +I+ATDL LYF++R F ++V +
Sbjct: 629 HLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKN 688
Query: 437 --------EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRER 488
EY ++I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER
Sbjct: 689 YQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLER 748
Query: 489 LELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWE 548
L P + DRN+ ELP+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+
Sbjct: 749 TVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWK 808
Query: 549 EL 550
L
Sbjct: 809 AL 810
Score = 72.0 bits (175), Expect = 1e-12
Identities = 46/175 (26%), Positives = 86/175 (49%), Gaps = 8/175 (4%)
Query: 24 EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKS 83
+ E S ALLE+V D+ +E ++E++V K++ R TLL+ +RCS+ + T+
Sbjct: 52 QVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRL 110
Query: 84 FELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEA 143
F + D + S + ++ + VA T VN+ D + P F + A
Sbjct: 111 FSVQPDSVLEDC------LVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFA 164
Query: 144 DQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGL 198
D+++ + +++L PI N ++ V +N+L+G F D+ +F ++ F L
Sbjct: 165 DELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATL 218
>gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]
Length = 854
Score = 347 bits (889), Expect = 2e-95
Identities = 206/602 (34%), Positives = 315/602 (52%), Gaps = 58/602 (9%)
Query: 4 YLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCE 63
YL F + + L E R + LL N +FEE TD+E+ K + + L CE
Sbjct: 212 YLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCE 271
Query: 64 RCSVLLLE--------DIESPVVKFTKSFELMSPKCSADAENSF----------KESME- 104
R SV LL+ D+ S ++ ++ + P+ E F KE ++
Sbjct: 272 RYSVGLLDMTKEKEFFDVWSVLMGESQPYS--GPRTPDGREIVFYKVIDYILHGKEEIKV 329
Query: 105 --KSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIW 160
S W + + + VA +G NI +A D F + + SG+ I++VL +PI
Sbjct: 330 IPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIV 389
Query: 161 NSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVAL 220
N +I+GVA NR DGKPFD+ D+ L E+ F G + NT YD++ K ++ +A
Sbjct: 390 NKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQ 449
Query: 221 DVLSYHATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDF 258
D++ YH C + E+ L E A I + HF D
Sbjct: 450 DMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDL 509
Query: 259 SLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLM 318
++ ++M+ ELG+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q M
Sbjct: 510 ECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTM 569
Query: 319 FAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHH 378
F +L T + T++E A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE H
Sbjct: 570 FTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERH 628
Query: 379 HFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG-- 436
H +L E NI+ NL+ +++ ++ L+ +I+ATDL LYF++R F ++V +
Sbjct: 629 HLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKN 688
Query: 437 --------EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRER 488
EY ++I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER
Sbjct: 689 YQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLER 748
Query: 489 LELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWE 548
L P + DRN+ ELP+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+
Sbjct: 749 TVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWK 808
Query: 549 EL 550
L
Sbjct: 809 AL 810
Score = 72.0 bits (175), Expect = 1e-12
Identities = 46/175 (26%), Positives = 86/175 (49%), Gaps = 8/175 (4%)
Query: 24 EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKS 83
+ E S ALLE+V D+ +E ++E++V K++ R TLL+ +RCS+ + T+
Sbjct: 52 QVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRL 110
Query: 84 FELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEA 143
F + D + S + ++ + VA T VN+ D + P F + A
Sbjct: 111 FSVQPDSVLEDC------LVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFA 164
Query: 144 DQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGL 198
D+++ + +++L PI N ++ V +N+L+G F D+ +F ++ F L
Sbjct: 165 DELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATL 218
>gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]
Length = 779
Score = 341 bits (875), Expect = 9e-94
Identities = 195/570 (34%), Positives = 317/570 (55%), Gaps = 18/570 (3%)
Query: 5 LPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCER 64
L + +AI Q+ K+ E + LL+V F+ ++ +++ IM A+ L+ +R
Sbjct: 227 LAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADR 286
Query: 65 CSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVAST 124
C++ ++ K+ EL S E K +K+ + I IA VA T
Sbjct: 287 CALFQVDH---------KNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVART 337
Query: 125 GLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDA 184
G +NI DAY DPRF+ E D +G+ R++LC+PI S +IGV Q++N++ G F
Sbjct: 338 GEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV-SRGSVIGVVQMVNKISGSAFSKT 396
Query: 185 DQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPL 244
D+ F+ F +FC L ++ MY +++ S V ++ LSYH+ C+ E +P+
Sbjct: 397 DENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPV 456
Query: 245 VSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVL 304
I+ HFD + + + ++M + E LCR++++V+KNYR V
Sbjct: 457 RLCKEIELFHFDIGPFE---NMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVP 513
Query: 305 YHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSA 364
YHNW+HA V M+A+L + T++E +++ CLCHDLDHRG +N++ K
Sbjct: 514 YHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHP 571
Query: 365 LAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFE 424
LA LY TS T+E HHF+ V ILQ EGHNIF+ LSS EY ++++++++I+ATDL LYF
Sbjct: 572 LAALYSTS-TMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFG 630
Query: 425 RRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQG 484
R + E+ G + N ++HRD ++MTACDL +VTK W +++ A + +EF+ +G
Sbjct: 631 NRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEG 690
Query: 485 DRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNR 544
D E +L + P + DR++KDE+P+ QL + +++ +P Y L ++ +P+L + N
Sbjct: 691 D-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNL 749
Query: 545 SKWEELHQKRLLASTASS-SPASVMVAKED 573
S+WE++ + A+ SS S A A ED
Sbjct: 750 SQWEKVIRGEETATWISSPSVAQKAAASED 779
Score = 37.4 bits (85), Expect = 0.038
Identities = 28/108 (25%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 116 SIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNR 175
+++ VA + + + D D RF SG I+SVLC+PI + +IG+ ++
Sbjct: 150 TVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRH 209
Query: 176 LDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVL 223
+ F + Q + A + + + I+ QV + AKQ+ D L
Sbjct: 210 WGKEAFCLSHQEVATANLAWASVAIHQV----QVCRGLAKQTELNDFL 253
>gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]
Length = 789
Score = 341 bits (875), Expect = 9e-94
Identities = 195/570 (34%), Positives = 317/570 (55%), Gaps = 18/570 (3%)
Query: 5 LPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCER 64
L + +AI Q+ K+ E + LL+V F+ ++ +++ IM A+ L+ +R
Sbjct: 237 LAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADR 296
Query: 65 CSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVAST 124
C++ ++ K+ EL S E K +K+ + I IA VA T
Sbjct: 297 CALFQVDH---------KNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVART 347
Query: 125 GLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDA 184
G +NI DAY DPRF+ E D +G+ R++LC+PI S +IGV Q++N++ G F
Sbjct: 348 GEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV-SRGSVIGVVQMVNKISGSAFSKT 406
Query: 185 DQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPL 244
D+ F+ F +FC L ++ MY +++ S V ++ LSYH+ C+ E +P+
Sbjct: 407 DENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPV 466
Query: 245 VSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVL 304
I+ HFD + + + ++M + E LCR++++V+KNYR V
Sbjct: 467 RLCKEIELFHFDIGPFE---NMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVP 523
Query: 305 YHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSA 364
YHNW+HA V M+A+L + T++E +++ CLCHDLDHRG +N++ K
Sbjct: 524 YHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHP 581
Query: 365 LAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFE 424
LA LY TS T+E HHF+ V ILQ EGHNIF+ LSS EY ++++++++I+ATDL LYF
Sbjct: 582 LAALYSTS-TMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFG 640
Query: 425 RRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQG 484
R + E+ G + N ++HRD ++MTACDL +VTK W +++ A + +EF+ +G
Sbjct: 641 NRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEG 700
Query: 485 DRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNR 544
D E +L + P + DR++KDE+P+ QL + +++ +P Y L ++ +P+L + N
Sbjct: 701 D-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNL 759
Query: 545 SKWEELHQKRLLASTASS-SPASVMVAKED 573
S+WE++ + A+ SS S A A ED
Sbjct: 760 SQWEKVIRGEETATWISSPSVAQKAAASED 789
Score = 37.4 bits (85), Expect = 0.038
Identities = 28/108 (25%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 116 SIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNR 175
+++ VA + + + D D RF SG I+SVLC+PI + +IG+ ++
Sbjct: 160 TVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRH 219
Query: 176 LDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVL 223
+ F + Q + A + + + I+ QV + AKQ+ D L
Sbjct: 220 WGKEAFCLSHQEVATANLAWASVAIHQV----QVCRGLAKQTELNDFL 263
>gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]
Length = 575
Score = 326 bits (836), Expect = 3e-89
Identities = 175/478 (36%), Positives = 266/478 (55%), Gaps = 35/478 (7%)
Query: 107 SYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNH 164
S W + + + VA +G NI +A D F + + SG+ I++VL +PI N
Sbjct: 55 SADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKE 114
Query: 165 QIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLS 224
+I+GVA NR DGKPFD+ D+ L E+ F G + NT YD++ K ++ +A D++
Sbjct: 115 EIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVL 174
Query: 225 YHATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDFSLDV 262
YH C + E+ L E A I + HF D
Sbjct: 175 YHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTE 234
Query: 263 DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAML 322
++ ++M+ ELG+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q MF +L
Sbjct: 235 LDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLL 294
Query: 323 TTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNH 382
T + T++E A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH
Sbjct: 295 MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEF 353
Query: 383 AVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG------ 436
+L E NI+ NL+ +++ ++ L+ +I+ATDL LYF++R F ++V +
Sbjct: 354 GKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDK 413
Query: 437 ----EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELK 492
EY ++I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER L
Sbjct: 414 KSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLD 473
Query: 493 LTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 550
P + DRN+ ELP+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+ L
Sbjct: 474 QQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 531
>gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]
Length = 932
Score = 320 bits (819), Expect = 3e-87
Identities = 190/569 (33%), Positives = 299/569 (52%), Gaps = 41/569 (7%)
Query: 7 FCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCS 66
+ +++ F +K +ALL+V +LF D+ ++++I+ A+ L E CS
Sbjct: 363 YTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICS 422
Query: 67 VLLLEDIESPVVKFT------KSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL 120
V LL+ E F +S+E+ P + IA
Sbjct: 423 VFLLDQNELVAKVFDGGVVDDESYEIRIPA-----------------------DQGIAGH 459
Query: 121 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 180
VA+TG +NI DAY P F D +GF R++LC PI N N ++IGVA+++N+++G
Sbjct: 460 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 519
Query: 181 FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA 240
F D+ L AF I+CG+ I ++++Y +V ++ + +A +++ YH S E K
Sbjct: 520 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 579
Query: 241 NIPLVSELAIDDIHFDDF-----SLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLT 295
I V+ + D +F F SL D A L M ++ + +KID TL R+ L
Sbjct: 580 GIQPVAAI---DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLM 636
Query: 296 VRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNN 355
V+K YR YHNW HAF+V + + + L ++EI A+ + C+CHDLDHRGTNN
Sbjct: 637 VKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNN 696
Query: 356 AFQAKSGSALAQLYGT-SATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSI 414
+FQ S S LA LY + + +E HHF A+ IL + G NIF + S K+Y ++ L++ I
Sbjct: 697 SFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDII 756
Query: 415 LATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAE 474
LATDL + + ++ G YD N K H + +LMT+CDL TK W+ +R++AE
Sbjct: 757 LATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE 815
Query: 475 LVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLK 534
L+ EFF QGD E+ + P + DR K +P LQ+ +++ I MP+Y+ L + K
Sbjct: 816 LIYKEFFSQGDLEK-AMGNRPMEMMDR-EKAYIPELQISFMEHIAMPIYKLLQDLFPKAA 873
Query: 535 PMLDSVATNRSKWEELHQKRLLASTASSS 563
+ + VA+NR W ++ K + S++
Sbjct: 874 ELYERVASNREHWTKVSHKFTIRGLPSNN 902
Score = 37.0 bits (84), Expect = 0.049
Identities = 34/187 (18%), Positives = 79/187 (42%), Gaps = 24/187 (12%)
Query: 26 ERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFE 85
+R R +L++ +L++ D + K++ Q + RC +LL+ + +
Sbjct: 216 DRDRKILQLCGELYD--LDASSLQLKVLQYLQQETRASRCCLLLVSE------------D 261
Query: 86 LMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQ 145
+ C + E + S+ + E S L S+ Q +
Sbjct: 262 NLQLSCKVIGDKVLGEEV---SFPLTGCLGQVVEDKKSIQLKDLTSEDVQ------QLQS 312
Query: 146 ISGFHIRSVLCVPIWN-SNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTI 204
+ G ++++LCVP+ + + Q++ +A N+L+G F D D+ + + + + +T+
Sbjct: 313 MLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTL 372
Query: 205 MYDQVKK 211
+ + +K
Sbjct: 373 AFQKEQK 379
>gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]
Length = 934
Score = 320 bits (819), Expect = 3e-87
Identities = 190/569 (33%), Positives = 299/569 (52%), Gaps = 41/569 (7%)
Query: 7 FCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCS 66
+ +++ F +K +ALL+V +LF D+ ++++I+ A+ L E CS
Sbjct: 365 YTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICS 424
Query: 67 VLLLEDIESPVVKFT------KSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL 120
V LL+ E F +S+E+ P + IA
Sbjct: 425 VFLLDQNELVAKVFDGGVVDDESYEIRIPA-----------------------DQGIAGH 461
Query: 121 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 180
VA+TG +NI DAY P F D +GF R++LC PI N N ++IGVA+++N+++G
Sbjct: 462 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 521
Query: 181 FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA 240
F D+ L AF I+CG+ I ++++Y +V ++ + +A +++ YH S E K
Sbjct: 522 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 581
Query: 241 NIPLVSELAIDDIHFDDF-----SLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLT 295
I V+ + D +F F SL D A L M ++ + +KID TL R+ L
Sbjct: 582 GIQPVAAI---DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLM 638
Query: 296 VRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNN 355
V+K YR YHNW HAF+V + + + L ++EI A+ + C+CHDLDHRGTNN
Sbjct: 639 VKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNN 698
Query: 356 AFQAKSGSALAQLYGT-SATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSI 414
+FQ S S LA LY + + +E HHF A+ IL + G NIF + S K+Y ++ L++ I
Sbjct: 699 SFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDII 758
Query: 415 LATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAE 474
LATDL + + ++ G YD N K H + +LMT+CDL TK W+ +R++AE
Sbjct: 759 LATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE 817
Query: 475 LVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLK 534
L+ EFF QGD E+ + P + DR K +P LQ+ +++ I MP+Y+ L + K
Sbjct: 818 LIYKEFFSQGDLEK-AMGNRPMEMMDR-EKAYIPELQISFMEHIAMPIYKLLQDLFPKAA 875
Query: 535 PMLDSVATNRSKWEELHQKRLLASTASSS 563
+ + VA+NR W ++ K + S++
Sbjct: 876 ELYERVASNREHWTKVSHKFTIRGLPSNN 904
Score = 37.0 bits (84), Expect = 0.049
Identities = 34/187 (18%), Positives = 79/187 (42%), Gaps = 24/187 (12%)
Query: 26 ERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFE 85
+R R +L++ +L++ D + K++ Q + RC +LL+ + +
Sbjct: 218 DRDRKILQLCGELYD--LDASSLQLKVLQYLQQETRASRCCLLLVSE------------D 263
Query: 86 LMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQ 145
+ C + E + S+ + E S L S+ Q +
Sbjct: 264 NLQLSCKVIGDKVLGEEV---SFPLTGCLGQVVEDKKSIQLKDLTSEDVQ------QLQS 314
Query: 146 ISGFHIRSVLCVPIWN-SNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTI 204
+ G ++++LCVP+ + + Q++ +A N+L+G F D D+ + + + + +T+
Sbjct: 315 MLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTL 374
Query: 205 MYDQVKK 211
+ + +K
Sbjct: 375 AFQKEQK 381
>gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]
Length = 941
Score = 320 bits (819), Expect = 3e-87
Identities = 190/569 (33%), Positives = 299/569 (52%), Gaps = 41/569 (7%)
Query: 7 FCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCS 66
+ +++ F +K +ALL+V +LF D+ ++++I+ A+ L E CS
Sbjct: 372 YTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICS 431
Query: 67 VLLLEDIESPVVKFT------KSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL 120
V LL+ E F +S+E+ P + IA
Sbjct: 432 VFLLDQNELVAKVFDGGVVDDESYEIRIPA-----------------------DQGIAGH 468
Query: 121 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 180
VA+TG +NI DAY P F D +GF R++LC PI N N ++IGVA+++N+++G
Sbjct: 469 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 528
Query: 181 FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA 240
F D+ L AF I+CG+ I ++++Y +V ++ + +A +++ YH S E K
Sbjct: 529 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 588
Query: 241 NIPLVSELAIDDIHFDDF-----SLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLT 295
I V+ + D +F F SL D A L M ++ + +KID TL R+ L
Sbjct: 589 GIQPVAAI---DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLM 645
Query: 296 VRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNN 355
V+K YR YHNW HAF+V + + + L ++EI A+ + C+CHDLDHRGTNN
Sbjct: 646 VKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNN 705
Query: 356 AFQAKSGSALAQLYGT-SATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSI 414
+FQ S S LA LY + + +E HHF A+ IL + G NIF + S K+Y ++ L++ I
Sbjct: 706 SFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDII 765
Query: 415 LATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAE 474
LATDL + + ++ G YD N K H + +LMT+CDL TK W+ +R++AE
Sbjct: 766 LATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE 824
Query: 475 LVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLK 534
L+ EFF QGD E+ + P + DR K +P LQ+ +++ I MP+Y+ L + K
Sbjct: 825 LIYKEFFSQGDLEK-AMGNRPMEMMDR-EKAYIPELQISFMEHIAMPIYKLLQDLFPKAA 882
Query: 535 PMLDSVATNRSKWEELHQKRLLASTASSS 563
+ + VA+NR W ++ K + S++
Sbjct: 883 ELYERVASNREHWTKVSHKFTIRGLPSNN 911
Score = 37.0 bits (84), Expect = 0.049
Identities = 34/187 (18%), Positives = 79/187 (42%), Gaps = 24/187 (12%)
Query: 26 ERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFE 85
+R R +L++ +L++ D + K++ Q + RC +LL+ + +
Sbjct: 225 DRDRKILQLCGELYD--LDASSLQLKVLQYLQQETRASRCCLLLVSE------------D 270
Query: 86 LMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQ 145
+ C + E + S+ + E S L S+ Q +
Sbjct: 271 NLQLSCKVIGDKVLGEEV---SFPLTGCLGQVVEDKKSIQLKDLTSEDVQ------QLQS 321
Query: 146 ISGFHIRSVLCVPIWN-SNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTI 204
+ G ++++LCVP+ + + Q++ +A N+L+G F D D+ + + + + +T+
Sbjct: 322 MLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTL 381
Query: 205 MYDQVKK 211
+ + +K
Sbjct: 382 AFQKEQK 388
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 159 bits (401), Expect = 9e-39
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 255 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 314
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 54 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 113
Query: 315 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 374
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 114 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 173
Query: 375 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 434
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 174 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 233
Query: 435 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 494
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 234 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 290
Query: 495 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 550
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 291 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 346
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 159 bits (401), Expect = 9e-39
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 255 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 314
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 54 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 113
Query: 315 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 374
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 114 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 173
Query: 375 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 434
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 174 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 233
Query: 435 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 494
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 234 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 290
Query: 495 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 550
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 291 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 346
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 159 bits (401), Expect = 9e-39
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 255 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 314
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 235 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 294
Query: 315 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 374
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 295 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 354
Query: 375 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 434
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 355 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 414
Query: 435 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 494
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 415 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 471
Query: 495 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 550
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 472 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 527
>gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]
Length = 552
Score = 159 bits (401), Expect = 9e-39
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 255 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 314
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 220 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 279
Query: 315 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 374
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 280 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 339
Query: 375 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 434
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 340 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 399
Query: 435 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 494
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 400 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 456
Query: 495 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 550
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 457 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 512
>gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens]
Length = 526
Score = 159 bits (401), Expect = 9e-39
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 255 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 314
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 194 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 253
Query: 315 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 374
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 254 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 313
Query: 375 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 434
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 314 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 373
Query: 435 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 494
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 374 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 430
Query: 495 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 550
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 431 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 486
>gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 159 bits (401), Expect = 9e-39
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 255 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 314
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 44 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 103
Query: 315 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 374
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 104 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 163
Query: 375 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 434
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 164 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 223
Query: 435 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 494
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 224 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 280
Query: 495 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 550
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 281 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 336
>gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 159 bits (401), Expect = 9e-39
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 255 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 314
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 54 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 113
Query: 315 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 374
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 114 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 173
Query: 375 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 434
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 174 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 233
Query: 435 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 494
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 234 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 290
Query: 495 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 550
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 291 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 346
>gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens]
Length = 491
Score = 159 bits (401), Expect = 9e-39
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 255 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 314
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 159 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 218
Query: 315 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 374
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 219 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 278
Query: 375 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 434
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 279 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 338
Query: 435 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 494
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 339 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 395
Query: 495 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 550
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 396 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 451
>gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens]
Length = 459
Score = 159 bits (401), Expect = 9e-39
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 255 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 314
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 127 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 186
Query: 315 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 374
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 187 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 246
Query: 375 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 434
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 247 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 306
Query: 435 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 494
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 307 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 363
Query: 495 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 550
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 364 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 419
>gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 159 bits (401), Expect = 9e-39
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 255 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 314
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 44 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 103
Query: 315 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 374
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 104 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 163
Query: 375 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 434
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 164 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 223
Query: 435 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 494
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 224 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 280
Query: 495 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 550
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 281 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 336
>gi|48762734 phosphodiesterase 9A isoform i [Homo sapiens]
Length = 433
Score = 159 bits (401), Expect = 9e-39
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 255 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 314
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 101 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 160
Query: 315 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 374
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 161 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 220
Query: 375 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 434
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 221 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 280
Query: 435 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 494
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 281 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 337
Query: 495 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 550
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 338 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 393
>gi|48762732 phosphodiesterase 9A isoform h [Homo sapiens]
Length = 507
Score = 159 bits (401), Expect = 9e-39
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 255 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 314
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 175 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 234
Query: 315 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 374
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 235 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 294
Query: 375 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 434
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 295 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 354
Query: 435 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 494
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 355 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 411
Query: 495 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 550
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 412 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 467
>gi|48762730 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 159 bits (401), Expect = 9e-39
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 255 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 314
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 54 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 113
Query: 315 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 374
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 114 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 173
Query: 375 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 434
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 174 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 233
Query: 435 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 494
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 234 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 290
Query: 495 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 550
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 291 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 346
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.134 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,628,618
Number of Sequences: 37866
Number of extensions: 724859
Number of successful extensions: 2509
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 2255
Number of HSP's gapped (non-prelim): 112
length of query: 575
length of database: 18,247,518
effective HSP length: 108
effective length of query: 467
effective length of database: 14,157,990
effective search space: 6611781330
effective search space used: 6611781330
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.