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Search of human proteins with 116536087
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]
(683 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens] 1357 0.0
gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens] 1254 0.0
gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens] 1147 0.0
gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens] 981 0.0
gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens] 518 e-147
gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens] 518 e-147
gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens] 518 e-147
gi|170650674 phosphodiesterase 6A [Homo sapiens] 389 e-108
gi|157364939 phosphodiesterase 6C [Homo sapiens] 387 e-107
gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens] 380 e-105
gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens] 380 e-105
gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens] 360 3e-99
gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens] 360 3e-99
gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens] 349 5e-96
gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens] 349 5e-96
gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens] 349 5e-96
gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens] 326 4e-89
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 159 1e-38
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 159 1e-38
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 159 1e-38
gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens] 159 1e-38
gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens] 159 1e-38
gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens] 159 1e-38
gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens] 159 1e-38
gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens] 159 1e-38
gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens] 159 1e-38
gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens] 159 1e-38
gi|48762734 phosphodiesterase 9A isoform i [Homo sapiens] 159 1e-38
gi|48762732 phosphodiesterase 9A isoform h [Homo sapiens] 159 1e-38
gi|48762730 phosphodiesterase 9A isoform g [Homo sapiens] 159 1e-38
>gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]
Length = 683
Score = 1357 bits (3512), Expect = 0.0
Identities = 683/683 (100%), Positives = 683/683 (100%)
Query: 1 MLKQARRPLFRNVLSATQWKKVKITRLVQISGASLAEKQEKHQDFLIQRQTKTKDRRFND 60
MLKQARRPLFRNVLSATQWKKVKITRLVQISGASLAEKQEKHQDFLIQRQTKTKDRRFND
Sbjct: 1 MLKQARRPLFRNVLSATQWKKVKITRLVQISGASLAEKQEKHQDFLIQRQTKTKDRRFND 60
Query: 61 EIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAI 120
EIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAI
Sbjct: 61 EIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAI 120
Query: 121 SNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLED 180
SNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLED
Sbjct: 121 SNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLED 180
Query: 181 IESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISD 240
IESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISD
Sbjct: 181 IESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISD 240
Query: 241 AYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAF 300
AYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAF
Sbjct: 241 AYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAF 300
Query: 301 VIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDD 360
VIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDD
Sbjct: 301 VIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDD 360
Query: 361 IHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAF 420
IHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAF
Sbjct: 361 IHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAF 420
Query: 421 NVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTS 480
NVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTS
Sbjct: 421 NVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTS 480
Query: 481 ATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFEL 540
ATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFEL
Sbjct: 481 ATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFEL 540
Query: 541 VSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELK 600
VSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELK
Sbjct: 541 VSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELK 600
Query: 601 LTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQ 660
LTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQ
Sbjct: 601 LTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQ 660
Query: 661 KRLLASTASSSPASVMVAKEDRN 683
KRLLASTASSSPASVMVAKEDRN
Sbjct: 661 KRLLASTASSSPASVMVAKEDRN 683
>gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]
Length = 933
Score = 1254 bits (3246), Expect = 0.0
Identities = 629/630 (99%), Positives = 630/630 (100%)
Query: 54 KDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYL 113
+DRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYL
Sbjct: 304 QDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYL 363
Query: 114 PFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERC 173
PFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERC
Sbjct: 364 PFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERC 423
Query: 174 SVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTG 233
SVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTG
Sbjct: 424 SVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTG 483
Query: 234 LPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDAD 293
LPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDAD
Sbjct: 484 LPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDAD 543
Query: 294 QRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLV 353
QRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLV
Sbjct: 544 QRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLV 603
Query: 354 SELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLY 413
SELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLY
Sbjct: 604 SELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLY 663
Query: 414 HNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSAL 473
HNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSAL
Sbjct: 664 HNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSAL 723
Query: 474 AQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFER 533
AQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFER
Sbjct: 724 AQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFER 783
Query: 534 RTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGD 593
RTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGD
Sbjct: 784 RTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGD 843
Query: 594 RERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRS 653
RERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRS
Sbjct: 844 RERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRS 903
Query: 654 KWEELHQKRLLASTASSSPASVMVAKEDRN 683
KWEELHQKRLLASTASSSPASVMVAKEDRN
Sbjct: 904 KWEELHQKRLLASTASSSPASVMVAKEDRN 933
Score = 98.2 bits (243), Expect = 2e-20
Identities = 63/208 (30%), Positives = 116/208 (55%), Gaps = 16/208 (7%)
Query: 131 KEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIES-PVVKFT 189
K++ + LE+V D+ + DL + KI+ ++ +RCS+ L+E + +
Sbjct: 197 KKHNERQFFLELVKDISND-LDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVS 255
Query: 190 KSFELMSPK----CSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDP 245
K F++ + CS+ ENS + + W I V G VNI DAYQD
Sbjct: 256 KFFDVHAGTPLLPCSS-TENSNEVQVP------W--GKGIIGYVGEHGETVNIPDAYQDR 306
Query: 246 RFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL-DGKPFDDADQRLFEAFVIFC 304
RF+ E D+++G+ +S+LC+PI +S+ +IIGVAQ +N++ +G PF + D+++ + ++ FC
Sbjct: 307 RFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFC 366
Query: 305 GLGINNTIMYDQVKKSWAKQSVALDVLS 332
G+ I+N ++ +K + + L+V++
Sbjct: 367 GIAISNAQLFAASRKEYERSRALLEVVN 394
>gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]
Length = 575
Score = 1147 bits (2966), Expect = 0.0
Identities = 575/575 (100%), Positives = 575/575 (100%)
Query: 109 MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLL 168
MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLL
Sbjct: 1 MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLL 60
Query: 169 KCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL 228
KCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL
Sbjct: 61 KCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL 120
Query: 229 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 288
VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP
Sbjct: 121 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 180
Query: 289 FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA 348
FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA
Sbjct: 181 FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA 240
Query: 349 NIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY 408
NIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY
Sbjct: 241 NIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY 300
Query: 409 RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAK 468
RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAK
Sbjct: 301 RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAK 360
Query: 469 SGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLT 528
SGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLT
Sbjct: 361 SGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLT 420
Query: 529 LYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEF 588
LYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEF
Sbjct: 421 LYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEF 480
Query: 589 FEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSV 648
FEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSV
Sbjct: 481 FEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSV 540
Query: 649 ATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN 683
ATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN
Sbjct: 541 ATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN 575
Score = 74.3 bits (181), Expect = 3e-13
Identities = 31/91 (34%), Positives = 64/91 (70%), Gaps = 1/91 (1%)
Query: 54 KDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYL 113
+D RF+ E D+++G+ +S+LC+PI +S+ +IIGVAQ +N++ +G PF + D+++ + ++
Sbjct: 135 QDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL-DGKPFDDADQRLFEAFV 193
Query: 114 PFCGIAISNAQLFAASRKEYERSRALLEVVN 144
FCG+ I+N ++ +K + + L+V++
Sbjct: 194 IFCGLGINNTIMYDQVKKSWAKQSVALDVLS 224
>gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]
Length = 489
Score = 981 bits (2537), Expect = 0.0
Identities = 489/489 (100%), Positives = 489/489 (100%)
Query: 195 MSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI 254
MSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI
Sbjct: 1 MSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI 60
Query: 255 SGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMY 314
SGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMY
Sbjct: 61 SGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMY 120
Query: 315 DQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMI 374
DQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMI
Sbjct: 121 DQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMI 180
Query: 375 TAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAG 434
TAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAG
Sbjct: 181 TAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAG 240
Query: 435 FQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMI 494
FQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMI
Sbjct: 241 FQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMI 300
Query: 495 LQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHR 554
LQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHR
Sbjct: 301 LQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHR 360
Query: 555 DIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDE 614
DIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDE
Sbjct: 361 DIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDE 420
Query: 615 LPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPAS 674
LPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPAS
Sbjct: 421 LPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPAS 480
Query: 675 VMVAKEDRN 683
VMVAKEDRN
Sbjct: 481 VMVAKEDRN 489
Score = 74.3 bits (181), Expect = 3e-13
Identities = 31/91 (34%), Positives = 64/91 (70%), Gaps = 1/91 (1%)
Query: 54 KDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYL 113
+D RF+ E D+++G+ +S+LC+PI +S+ +IIGVAQ +N++ +G PF + D+++ + ++
Sbjct: 49 QDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL-DGKPFDDADQRLFEAFV 107
Query: 114 PFCGIAISNAQLFAASRKEYERSRALLEVVN 144
FCG+ I+N ++ +K + + L+V++
Sbjct: 108 IFCGLGINNTIMYDQVKKSWAKQSVALDVLS 138
>gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]
Length = 875
Score = 518 bits (1333), Expect = e-147
Identities = 272/623 (43%), Positives = 403/623 (64%), Gaps = 23/623 (3%)
Query: 54 KDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIP-EGAPFTEDDEKVMQMY 112
+D RFN E+D++TGYKT+S+LCMPI++ E++GVAQAINK G FTE DEK Y
Sbjct: 247 EDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAY 306
Query: 113 LPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCER 172
L FCGI + NAQL+ S E +R++ LL++ + +FEEQ LE I+KKI + ++ ++
Sbjct: 307 LAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQK 366
Query: 173 CSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVAST 232
C++ ++++ S F+ F + + ++ +E IN A+ V +T
Sbjct: 367 CTIFIVDEDCSD--SFSSVFHMECEELEKSSDTLTREHDANK------INYMYAQYVKNT 418
Query: 233 GLPVNISDAYQDPRFDAEADQISGFH---IRSVLCVPIWNSN-HQIIGVAQVLNRLDG-- 286
P+NI D +D RF + + IRS+LC PI N +++IGV Q++N+++
Sbjct: 419 MEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENT 478
Query: 287 ---KPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVD 343
KPF+ D++ EAFVIFCGLGI NT MY+ V+++ AKQ V L+VLSYHA+ ++ E
Sbjct: 479 GKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETR 538
Query: 344 KFK---AANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRW 400
+ + AA +P L I D F DF L +RMF +L +VQ F++ +E LCRW
Sbjct: 539 ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRW 598
Query: 401 LLTVRKNYRM-VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHR 459
+L+V+KNYR V YHNWRHAFN Q MFA L Q+ LT++EILA+++ L HDLDHR
Sbjct: 599 ILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHR 658
Query: 460 GTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLK 519
G NN++ +S LAQLY S +EHHHF+ +MIL S G+ I + LS +EY ++++K
Sbjct: 659 GVNNSYIQRSEHPLAQLYCHSI-MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIK 717
Query: 520 QSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQ 579
Q+ILATDL LY +RR EFFEL+ K +++ + +++F +MLMTACDL A+TKPW I ++
Sbjct: 718 QAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQR 777
Query: 580 VAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNV 639
+AELV +EFF+QGDRER EL + P+ + +R +K+++P +Q+ +ID+IC+ LY+AL V+
Sbjct: 778 IAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSE 837
Query: 640 KLKPMLDSVATNRSKWEELHQKR 662
P+LD NR KW+ L +++
Sbjct: 838 DCFPLLDGCRKNRQKWQALAEQQ 860
Score = 107 bits (268), Expect = 3e-23
Identities = 67/205 (32%), Positives = 111/205 (54%), Gaps = 15/205 (7%)
Query: 132 EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLL-EDIESPVVKFTK 190
E ++ LLE+V D+ D+ + KI L+ +R S+ L+ ED + ++
Sbjct: 145 EGDQCSRLLELVKDI-SSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISR 203
Query: 191 SFELMSPKCSADAENSFKESMEKSSYS-DWLINNSIAELVASTGLPVNISDAYQDPRFDA 249
F++ AE S E + + +W N I VA+ G P+NI DAY+DPRF+A
Sbjct: 204 LFDV--------AEGSTLEEVSNNCIRLEW--NKGIVGHVAALGEPLNIKDAYEDPRFNA 253
Query: 250 EADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK--PFDDADQRLFEAFVIFCGLG 307
E DQI+G+ +S+LC+PI N +++GVAQ +N+ G F + D++ F A++ FCG+
Sbjct: 254 EVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIV 313
Query: 308 INNTIMYDQVKKSWAKQSVALDVLS 332
++N +Y+ + V LD+ S
Sbjct: 314 LHNAQLYETSLLENKRNQVLLDLAS 338
>gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]
Length = 823
Score = 518 bits (1333), Expect = e-147
Identities = 272/623 (43%), Positives = 403/623 (64%), Gaps = 23/623 (3%)
Query: 54 KDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIP-EGAPFTEDDEKVMQMY 112
+D RFN E+D++TGYKT+S+LCMPI++ E++GVAQAINK G FTE DEK Y
Sbjct: 195 EDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAY 254
Query: 113 LPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCER 172
L FCGI + NAQL+ S E +R++ LL++ + +FEEQ LE I+KKI + ++ ++
Sbjct: 255 LAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQK 314
Query: 173 CSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVAST 232
C++ ++++ S F+ F + + ++ +E IN A+ V +T
Sbjct: 315 CTIFIVDEDCSD--SFSSVFHMECEELEKSSDTLTREHDANK------INYMYAQYVKNT 366
Query: 233 GLPVNISDAYQDPRFDAEADQISGFH---IRSVLCVPIWNSN-HQIIGVAQVLNRLDG-- 286
P+NI D +D RF + + IRS+LC PI N +++IGV Q++N+++
Sbjct: 367 MEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENT 426
Query: 287 ---KPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVD 343
KPF+ D++ EAFVIFCGLGI NT MY+ V+++ AKQ V L+VLSYHA+ ++ E
Sbjct: 427 GKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETR 486
Query: 344 KFK---AANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRW 400
+ + AA +P L I D F DF L +RMF +L +VQ F++ +E LCRW
Sbjct: 487 ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRW 546
Query: 401 LLTVRKNYRM-VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHR 459
+L+V+KNYR V YHNWRHAFN Q MFA L Q+ LT++EILA+++ L HDLDHR
Sbjct: 547 ILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHR 606
Query: 460 GTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLK 519
G NN++ +S LAQLY S +EHHHF+ +MIL S G+ I + LS +EY ++++K
Sbjct: 607 GVNNSYIQRSEHPLAQLYCHSI-MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIK 665
Query: 520 QSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQ 579
Q+ILATDL LY +RR EFFEL+ K +++ + +++F +MLMTACDL A+TKPW I ++
Sbjct: 666 QAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQR 725
Query: 580 VAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNV 639
+AELV +EFF+QGDRER EL + P+ + +R +K+++P +Q+ +ID+IC+ LY+AL V+
Sbjct: 726 IAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSE 785
Query: 640 KLKPMLDSVATNRSKWEELHQKR 662
P+LD NR KW+ L +++
Sbjct: 786 DCFPLLDGCRKNRQKWQALAEQQ 808
Score = 107 bits (268), Expect = 3e-23
Identities = 67/205 (32%), Positives = 111/205 (54%), Gaps = 15/205 (7%)
Query: 132 EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLL-EDIESPVVKFTK 190
E ++ LLE+V D+ D+ + KI L+ +R S+ L+ ED + ++
Sbjct: 93 EGDQCSRLLELVKDI-SSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISR 151
Query: 191 SFELMSPKCSADAENSFKESMEKSSYS-DWLINNSIAELVASTGLPVNISDAYQDPRFDA 249
F++ AE S E + + +W N I VA+ G P+NI DAY+DPRF+A
Sbjct: 152 LFDV--------AEGSTLEEVSNNCIRLEW--NKGIVGHVAALGEPLNIKDAYEDPRFNA 201
Query: 250 EADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK--PFDDADQRLFEAFVIFCGLG 307
E DQI+G+ +S+LC+PI N +++GVAQ +N+ G F + D++ F A++ FCG+
Sbjct: 202 EVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIV 261
Query: 308 INNTIMYDQVKKSWAKQSVALDVLS 332
++N +Y+ + V LD+ S
Sbjct: 262 LHNAQLYETSLLENKRNQVLLDLAS 286
>gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]
Length = 833
Score = 518 bits (1333), Expect = e-147
Identities = 272/623 (43%), Positives = 403/623 (64%), Gaps = 23/623 (3%)
Query: 54 KDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIP-EGAPFTEDDEKVMQMY 112
+D RFN E+D++TGYKT+S+LCMPI++ E++GVAQAINK G FTE DEK Y
Sbjct: 205 EDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAY 264
Query: 113 LPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCER 172
L FCGI + NAQL+ S E +R++ LL++ + +FEEQ LE I+KKI + ++ ++
Sbjct: 265 LAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQK 324
Query: 173 CSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVAST 232
C++ ++++ S F+ F + + ++ +E IN A+ V +T
Sbjct: 325 CTIFIVDEDCSD--SFSSVFHMECEELEKSSDTLTREHDANK------INYMYAQYVKNT 376
Query: 233 GLPVNISDAYQDPRFDAEADQISGFH---IRSVLCVPIWNSN-HQIIGVAQVLNRLDG-- 286
P+NI D +D RF + + IRS+LC PI N +++IGV Q++N+++
Sbjct: 377 MEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENT 436
Query: 287 ---KPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVD 343
KPF+ D++ EAFVIFCGLGI NT MY+ V+++ AKQ V L+VLSYHA+ ++ E
Sbjct: 437 GKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETR 496
Query: 344 KFK---AANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRW 400
+ + AA +P L I D F DF L +RMF +L +VQ F++ +E LCRW
Sbjct: 497 ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRW 556
Query: 401 LLTVRKNYRM-VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHR 459
+L+V+KNYR V YHNWRHAFN Q MFA L Q+ LT++EILA+++ L HDLDHR
Sbjct: 557 ILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHR 616
Query: 460 GTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLK 519
G NN++ +S LAQLY S +EHHHF+ +MIL S G+ I + LS +EY ++++K
Sbjct: 617 GVNNSYIQRSEHPLAQLYCHSI-MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIK 675
Query: 520 QSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQ 579
Q+ILATDL LY +RR EFFEL+ K +++ + +++F +MLMTACDL A+TKPW I ++
Sbjct: 676 QAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQR 735
Query: 580 VAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNV 639
+AELV +EFF+QGDRER EL + P+ + +R +K+++P +Q+ +ID+IC+ LY+AL V+
Sbjct: 736 IAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSE 795
Query: 640 KLKPMLDSVATNRSKWEELHQKR 662
P+LD NR KW+ L +++
Sbjct: 796 DCFPLLDGCRKNRQKWQALAEQQ 818
Score = 107 bits (268), Expect = 3e-23
Identities = 67/205 (32%), Positives = 111/205 (54%), Gaps = 15/205 (7%)
Query: 132 EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLL-EDIESPVVKFTK 190
E ++ LLE+V D+ D+ + KI L+ +R S+ L+ ED + ++
Sbjct: 103 EGDQCSRLLELVKDI-SSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISR 161
Query: 191 SFELMSPKCSADAENSFKESMEKSSYS-DWLINNSIAELVASTGLPVNISDAYQDPRFDA 249
F++ AE S E + + +W N I VA+ G P+NI DAY+DPRF+A
Sbjct: 162 LFDV--------AEGSTLEEVSNNCIRLEW--NKGIVGHVAALGEPLNIKDAYEDPRFNA 211
Query: 250 EADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK--PFDDADQRLFEAFVIFCGLG 307
E DQI+G+ +S+LC+PI N +++GVAQ +N+ G F + D++ F A++ FCG+
Sbjct: 212 EVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIV 271
Query: 308 INNTIMYDQVKKSWAKQSVALDVLS 332
++N +Y+ + V LD+ S
Sbjct: 272 LHNAQLYETSLLENKRNQVLLDLAS 296
>gi|170650674 phosphodiesterase 6A [Homo sapiens]
Length = 860
Score = 389 bits (998), Expect = e-108
Identities = 222/663 (33%), Positives = 356/663 (53%), Gaps = 66/663 (9%)
Query: 54 KDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYL 113
+D F D +D LT YKTK++L PI + +++ + A+NK+ +G+ FT+ DE+++ YL
Sbjct: 158 EDEHFCDFVDILTEYKTKNILASPIMNGK-DVVAIIMAVNKV-DGSHFTKRDEEILLKYL 215
Query: 114 PFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERC 173
F + + L E R + LL + +FEE TD+E+ K ++ + L C+R
Sbjct: 216 NFANLIMKVYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRY 275
Query: 174 SVLLLEDIESPVVKFTKSFELM-----------SPKCSADAENSFKESMEKSSYSD---- 218
SV LL+ + K + F++ P+ E +F + ++ +
Sbjct: 276 SVGLLD-----MTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKEDIK 330
Query: 219 ---------WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPI 267
W + + + VA GL NI +A + F + + + SG+ I++VL +PI
Sbjct: 331 VIPNPPPDHWALVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPI 390
Query: 268 WNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVA 327
N +I+GVA NR DGKPFD+ D+ L E+ F G + N Y+ + K ++ +
Sbjct: 391 VNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIF 450
Query: 328 LDVLSYHATCSKAEVDKFKA----------------------ANIPLVSELAIDDIHFDD 365
D++ YH C E+ K A +P + I+ HF D
Sbjct: 451 QDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSD 510
Query: 366 FSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQL 425
L ++ ++M+ EL +V KF I E L R++ ++ K YR + YHNWRH FNV Q
Sbjct: 511 LPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQT 570
Query: 426 MFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEH 485
MF++L T + T++E LA++ CHD+DHRGTNN +Q KS + LA+L+G S+ LE
Sbjct: 571 MFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILER 629
Query: 486 HHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS--- 542
HH +L+ E NIF NL+ +++ + ++ +I+ATDL LYF++RT F ++V
Sbjct: 630 HHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSK 689
Query: 543 --KGEYDWN-----IKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRE 595
+ E +W + ++I +M+MTACDL A+TKPWE+ QVA LV +EF+EQGD E
Sbjct: 690 TYESEQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLE 749
Query: 596 RLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKW 655
R L+ P + DRN+ DELP+LQ+ +ID +C +Y+ + + ++ PMLD + NR +W
Sbjct: 750 RTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEW 809
Query: 656 EEL 658
+ L
Sbjct: 810 KAL 812
>gi|157364939 phosphodiesterase 6C [Homo sapiens]
Length = 858
Score = 387 bits (994), Expect = e-107
Identities = 226/659 (34%), Positives = 351/659 (53%), Gaps = 57/659 (8%)
Query: 54 KDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYL 113
K+ F+D +DK TGY TK+LL PI E++ V A+NK+ + F++ DE+V YL
Sbjct: 160 KNSHFSDFMDKQTGYVTKNLLATPIVVGK-EVLAVIMAVNKV-NASEFSKQDEEVFSKYL 217
Query: 114 PFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERC 173
F I + E RS+ L+ N +FEE TD+E+ K ++ ++ L CER
Sbjct: 218 NFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERY 277
Query: 174 SVLLL------EDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSD--------- 218
S+ LL E + +K + PK E +F + ++ +
Sbjct: 278 SIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTP 337
Query: 219 ----WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNH 272
W + + + VA G N+ +A D F + + +G+ I++VL +PI N
Sbjct: 338 PADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKE 397
Query: 273 QIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLS 332
I+GVA NR DGKPFD+ D+ + E F G + NT YD++ K ++ +A ++L
Sbjct: 398 DIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLM 457
Query: 333 YHATCSKAEVDKF----KAANIPLVSELA-------------------IDDIHFDDFSLD 369
+ E+ + N+ ++ + + + F DF L
Sbjct: 458 NQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLT 517
Query: 370 VDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAM 429
+I +R+F E+ +V+KFK+ E L RW+ TVRK YR V YHNWRH FNV Q MF +
Sbjct: 518 EHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTL 577
Query: 430 LTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFN 489
L T + T++E A++ CHD+DHRGTNN +Q KS S LA+L+G S+ LE HH
Sbjct: 578 LMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHG-SSILERHHLE 636
Query: 490 HAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGE---- 545
++ +LQ E NIF NL+ +++ ++ L + +I+ATDL LYF++RT F ++V E
Sbjct: 637 YSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQT 696
Query: 546 ------YDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLEL 599
Y ++I +M+MTACDL A+TKPWE+ QVA +V +EF+EQGD ER L
Sbjct: 697 EEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVL 756
Query: 600 KLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 658
+ P + DRN++DELP+LQ+ +ID +C +Y+ + + ++ PML + NR +W+ L
Sbjct: 757 QQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSL 815
>gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]
Length = 853
Score = 380 bits (977), Expect = e-105
Identities = 227/656 (34%), Positives = 347/656 (52%), Gaps = 60/656 (9%)
Query: 58 FNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCG 117
F+ D+LT YKTK++L PI + +++ V A+NK+ G FT +DE V YL F
Sbjct: 160 FSSFADELTDYKTKNMLATPIMNGK-DVVAVIMAVNKL-NGPFFTSEDEDVFLKYLNFAT 217
Query: 118 IAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLL 177
+ + L E R + LL N +FEE TD+E+ K + + L CER SV L
Sbjct: 218 LYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGL 277
Query: 178 LE--------DIESPVVKFTKSFELMSPKCSADAENSF----------KESME---KSSY 216
L+ D+ S ++ ++ + P+ E F KE ++ S
Sbjct: 278 LDMTKEKEFFDVWSVLMGESQPYS--GPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSA 335
Query: 217 SDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNHQI 274
W + + + VA +G NI +A D F + + SG+ I++VL +PI N +I
Sbjct: 336 DHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEI 395
Query: 275 IGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYH 334
+GVA NR DGKPFD+ D+ L E+ F G + NT YD++ K ++ +A D++ YH
Sbjct: 396 VGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYH 455
Query: 335 ATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDFSLDVDA 372
C + E+ L E A I + HF D
Sbjct: 456 VKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELD 515
Query: 373 MITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTT 432
++ ++M+ ELG+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q MF +L T
Sbjct: 516 LVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMT 575
Query: 433 AGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAV 492
+ T++E A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH
Sbjct: 576 GKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGK 634
Query: 493 MILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG-------- 544
+L E NI+ NL+ +++ ++ L+ +I+ATDL LYF++R F ++V +
Sbjct: 635 FLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKS 694
Query: 545 --EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602
EY ++I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER L
Sbjct: 695 WVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQ 754
Query: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 658
P + DRN+ ELP+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+ L
Sbjct: 755 PIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 810
Score = 72.0 bits (175), Expect = 2e-12
Identities = 46/175 (26%), Positives = 86/175 (49%), Gaps = 8/175 (4%)
Query: 132 EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKS 191
+ E S ALLE+V D+ +E ++E++V K++ R TLL+ +RCS+ + T+
Sbjct: 52 QVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRL 110
Query: 192 FELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEA 251
F + D + S + ++ + VA T VN+ D + P F + A
Sbjct: 111 FSVQPDSVLEDC------LVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFA 164
Query: 252 DQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGL 306
D+++ + +++L PI N ++ V +N+L+G F D+ +F ++ F L
Sbjct: 165 DELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATL 218
>gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]
Length = 854
Score = 380 bits (977), Expect = e-105
Identities = 227/656 (34%), Positives = 347/656 (52%), Gaps = 60/656 (9%)
Query: 58 FNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCG 117
F+ D+LT YKTK++L PI + +++ V A+NK+ G FT +DE V YL F
Sbjct: 160 FSSFADELTDYKTKNMLATPIMNGK-DVVAVIMAVNKL-NGPFFTSEDEDVFLKYLNFAT 217
Query: 118 IAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLL 177
+ + L E R + LL N +FEE TD+E+ K + + L CER SV L
Sbjct: 218 LYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGL 277
Query: 178 LE--------DIESPVVKFTKSFELMSPKCSADAENSF----------KESME---KSSY 216
L+ D+ S ++ ++ + P+ E F KE ++ S
Sbjct: 278 LDMTKEKEFFDVWSVLMGESQPYS--GPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSA 335
Query: 217 SDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNHQI 274
W + + + VA +G NI +A D F + + SG+ I++VL +PI N +I
Sbjct: 336 DHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEI 395
Query: 275 IGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYH 334
+GVA NR DGKPFD+ D+ L E+ F G + NT YD++ K ++ +A D++ YH
Sbjct: 396 VGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYH 455
Query: 335 ATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDFSLDVDA 372
C + E+ L E A I + HF D
Sbjct: 456 VKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELD 515
Query: 373 MITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTT 432
++ ++M+ ELG+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q MF +L T
Sbjct: 516 LVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMT 575
Query: 433 AGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAV 492
+ T++E A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH
Sbjct: 576 GKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGK 634
Query: 493 MILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG-------- 544
+L E NI+ NL+ +++ ++ L+ +I+ATDL LYF++R F ++V +
Sbjct: 635 FLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKS 694
Query: 545 --EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602
EY ++I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER L
Sbjct: 695 WVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQ 754
Query: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 658
P + DRN+ ELP+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+ L
Sbjct: 755 PIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 810
Score = 72.0 bits (175), Expect = 2e-12
Identities = 46/175 (26%), Positives = 86/175 (49%), Gaps = 8/175 (4%)
Query: 132 EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKS 191
+ E S ALLE+V D+ +E ++E++V K++ R TLL+ +RCS+ + T+
Sbjct: 52 QVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRL 110
Query: 192 FELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEA 251
F + D + S + ++ + VA T VN+ D + P F + A
Sbjct: 111 FSVQPDSVLEDC------LVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFA 164
Query: 252 DQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGL 306
D+++ + +++L PI N ++ V +N+L+G F D+ +F ++ F L
Sbjct: 165 DELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATL 218
>gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]
Length = 779
Score = 360 bits (923), Expect = 3e-99
Identities = 210/628 (33%), Positives = 346/628 (55%), Gaps = 19/628 (3%)
Query: 55 DRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLP 114
D RF +G + +S+LC+PI ++ G++IG+ + + A F ++V L
Sbjct: 170 DERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEA-FCLSHQEVATANLA 228
Query: 115 FCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCS 174
+ +AI Q+ K+ E + LL+V F+ ++ +++ IM A+ L+ +RC+
Sbjct: 229 WASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCA 288
Query: 175 VLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGL 234
+ ++ K+ EL S E K +K+ + I IA VA TG
Sbjct: 289 LFQVDH---------KNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGE 339
Query: 235 PVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQ 294
+NI DAY DPRF+ E D +G+ R++LC+PI S +IGV Q++N++ G F D+
Sbjct: 340 VLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV-SRGSVIGVVQMVNKISGSAFSKTDE 398
Query: 295 RLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVS 354
F+ F +FC L ++ MY +++ S V ++ LSYH+ C+ E +P+
Sbjct: 399 NNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRL 458
Query: 355 ELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYH 414
I+ HFD + + + ++M + E LCR++++V+KNYR V YH
Sbjct: 459 CKEIELFHFDIGPFE---NMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYH 515
Query: 415 NWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALA 474
NW+HA V M+A+L + T++E +++ CLCHDLDHRG +N++ K LA
Sbjct: 516 NWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLA 573
Query: 475 QLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERR 534
LY TS T+E HHF+ V ILQ EGHNIF+ LSS EY ++++++++I+ATDL LYF R
Sbjct: 574 ALYSTS-TMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNR 632
Query: 535 TEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDR 594
+ E+ G + N ++HRD ++MTACDL +VTK W +++ A + +EF+ +GD
Sbjct: 633 KQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD- 691
Query: 595 ERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSK 654
E +L + P + DR++KDE+P+ QL + +++ +P Y L ++ +P+L + N S+
Sbjct: 692 EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQ 751
Query: 655 WEELHQKRLLASTASS-SPASVMVAKED 681
WE++ + A+ SS S A A ED
Sbjct: 752 WEKVIRGEETATWISSPSVAQKAAASED 779
Score = 37.4 bits (85), Expect = 0.046
Identities = 28/108 (25%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 224 SIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNR 283
+++ VA + + + D D RF SG I+SVLC+PI + +IG+ ++
Sbjct: 150 TVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRH 209
Query: 284 LDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVL 331
+ F + Q + A + + + I+ QV + AKQ+ D L
Sbjct: 210 WGKEAFCLSHQEVATANLAWASVAIHQV----QVCRGLAKQTELNDFL 253
>gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]
Length = 789
Score = 360 bits (923), Expect = 3e-99
Identities = 210/628 (33%), Positives = 346/628 (55%), Gaps = 19/628 (3%)
Query: 55 DRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLP 114
D RF +G + +S+LC+PI ++ G++IG+ + + A F ++V L
Sbjct: 180 DERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEA-FCLSHQEVATANLA 238
Query: 115 FCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCS 174
+ +AI Q+ K+ E + LL+V F+ ++ +++ IM A+ L+ +RC+
Sbjct: 239 WASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCA 298
Query: 175 VLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGL 234
+ ++ K+ EL S E K +K+ + I IA VA TG
Sbjct: 299 LFQVDH---------KNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGE 349
Query: 235 PVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQ 294
+NI DAY DPRF+ E D +G+ R++LC+PI S +IGV Q++N++ G F D+
Sbjct: 350 VLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV-SRGSVIGVVQMVNKISGSAFSKTDE 408
Query: 295 RLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVS 354
F+ F +FC L ++ MY +++ S V ++ LSYH+ C+ E +P+
Sbjct: 409 NNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRL 468
Query: 355 ELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYH 414
I+ HFD + + + ++M + E LCR++++V+KNYR V YH
Sbjct: 469 CKEIELFHFDIGPFE---NMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYH 525
Query: 415 NWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALA 474
NW+HA V M+A+L + T++E +++ CLCHDLDHRG +N++ K LA
Sbjct: 526 NWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLA 583
Query: 475 QLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERR 534
LY TS T+E HHF+ V ILQ EGHNIF+ LSS EY ++++++++I+ATDL LYF R
Sbjct: 584 ALYSTS-TMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNR 642
Query: 535 TEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDR 594
+ E+ G + N ++HRD ++MTACDL +VTK W +++ A + +EF+ +GD
Sbjct: 643 KQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD- 701
Query: 595 ERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSK 654
E +L + P + DR++KDE+P+ QL + +++ +P Y L ++ +P+L + N S+
Sbjct: 702 EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQ 761
Query: 655 WEELHQKRLLASTASS-SPASVMVAKED 681
WE++ + A+ SS S A A ED
Sbjct: 762 WEKVIRGEETATWISSPSVAQKAAASED 789
Score = 37.4 bits (85), Expect = 0.046
Identities = 28/108 (25%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 224 SIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNR 283
+++ VA + + + D D RF SG I+SVLC+PI + +IG+ ++
Sbjct: 160 TVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRH 219
Query: 284 LDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVL 331
+ F + Q + A + + + I+ QV + AKQ+ D L
Sbjct: 220 WGKEAFCLSHQEVATANLAWASVAIHQV----QVCRGLAKQTELNDFL 263
>gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]
Length = 932
Score = 349 bits (895), Expect = 5e-96
Identities = 210/639 (32%), Positives = 340/639 (53%), Gaps = 45/639 (7%)
Query: 48 QRQTKTKDRRFND--EIDKLTGYKTKSLLCMPIRS-SDGEIIGVAQAINKIPEGAPFTED 104
++ + KD D ++ + G + +++LC+P+ S + +++ +A A NK+ EG FT++
Sbjct: 294 KKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKL-EGDLFTDE 352
Query: 105 DEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRA 164
DE V+Q + +++ F +K +ALL+V +LF D+ ++++I+ A
Sbjct: 353 DEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEA 412
Query: 165 QTLLKCERCSVLLLEDIESPVVKFT------KSFELMSPKCSADAENSFKESMEKSSYSD 218
+ L E CSV LL+ E F +S+E+ P
Sbjct: 413 RNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPA-------------------- 452
Query: 219 WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVA 278
+ IA VA+TG +NI DAY P F D +GF R++LC PI N N ++IGVA
Sbjct: 453 ---DQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVA 509
Query: 279 QVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCS 338
+++N+++G F D+ L AF I+CG+ I ++++Y +V ++ + +A +++ YH S
Sbjct: 510 ELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVS 569
Query: 339 KAEVDKFKAANIPLVSELAIDDIHFDDF-----SLDVDAMITAALRMFMELGMVQKFKID 393
E K I V+ + D +F F SL D A L M ++ + +KID
Sbjct: 570 DDEYTKLLHDGIQPVAAI---DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKID 626
Query: 394 YETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLC 453
TL R+ L V+K YR YHNW HAF+V + + + L ++EI A+ + C+C
Sbjct: 627 CPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMC 686
Query: 454 HDLDHRGTNNAFQAKSGSALAQLYGT-SATLEHHHFNHAVMILQSEGHNIFANLSSKEYS 512
HDLDHRGTNN+FQ S S LA LY + + +E HHF A+ IL + G NIF + S K+Y
Sbjct: 687 HDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQ 746
Query: 513 DLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTK 572
++ L++ ILATDL + + ++ G YD N K H + +LMT+CDL TK
Sbjct: 747 RMLDLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTK 805
Query: 573 PWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQ 632
W+ +R++AEL+ EFF QGD E+ + P + DR K +P LQ+ +++ I MP+Y+
Sbjct: 806 GWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDR-EKAYIPELQISFMEHIAMPIYK 863
Query: 633 ALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSS 671
L + K + + VA+NR W ++ K + S++
Sbjct: 864 LLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNN 902
>gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]
Length = 934
Score = 349 bits (895), Expect = 5e-96
Identities = 210/639 (32%), Positives = 340/639 (53%), Gaps = 45/639 (7%)
Query: 48 QRQTKTKDRRFND--EIDKLTGYKTKSLLCMPIRS-SDGEIIGVAQAINKIPEGAPFTED 104
++ + KD D ++ + G + +++LC+P+ S + +++ +A A NK+ EG FT++
Sbjct: 296 KKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKL-EGDLFTDE 354
Query: 105 DEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRA 164
DE V+Q + +++ F +K +ALL+V +LF D+ ++++I+ A
Sbjct: 355 DEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEA 414
Query: 165 QTLLKCERCSVLLLEDIESPVVKFT------KSFELMSPKCSADAENSFKESMEKSSYSD 218
+ L E CSV LL+ E F +S+E+ P
Sbjct: 415 RNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPA-------------------- 454
Query: 219 WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVA 278
+ IA VA+TG +NI DAY P F D +GF R++LC PI N N ++IGVA
Sbjct: 455 ---DQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVA 511
Query: 279 QVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCS 338
+++N+++G F D+ L AF I+CG+ I ++++Y +V ++ + +A +++ YH S
Sbjct: 512 ELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVS 571
Query: 339 KAEVDKFKAANIPLVSELAIDDIHFDDF-----SLDVDAMITAALRMFMELGMVQKFKID 393
E K I V+ + D +F F SL D A L M ++ + +KID
Sbjct: 572 DDEYTKLLHDGIQPVAAI---DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKID 628
Query: 394 YETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLC 453
TL R+ L V+K YR YHNW HAF+V + + + L ++EI A+ + C+C
Sbjct: 629 CPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMC 688
Query: 454 HDLDHRGTNNAFQAKSGSALAQLYGT-SATLEHHHFNHAVMILQSEGHNIFANLSSKEYS 512
HDLDHRGTNN+FQ S S LA LY + + +E HHF A+ IL + G NIF + S K+Y
Sbjct: 689 HDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQ 748
Query: 513 DLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTK 572
++ L++ ILATDL + + ++ G YD N K H + +LMT+CDL TK
Sbjct: 749 RMLDLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTK 807
Query: 573 PWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQ 632
W+ +R++AEL+ EFF QGD E+ + P + DR K +P LQ+ +++ I MP+Y+
Sbjct: 808 GWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDR-EKAYIPELQISFMEHIAMPIYK 865
Query: 633 ALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSS 671
L + K + + VA+NR W ++ K + S++
Sbjct: 866 LLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNN 904
>gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]
Length = 941
Score = 349 bits (895), Expect = 5e-96
Identities = 210/639 (32%), Positives = 340/639 (53%), Gaps = 45/639 (7%)
Query: 48 QRQTKTKDRRFND--EIDKLTGYKTKSLLCMPIRS-SDGEIIGVAQAINKIPEGAPFTED 104
++ + KD D ++ + G + +++LC+P+ S + +++ +A A NK+ EG FT++
Sbjct: 303 KKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKL-EGDLFTDE 361
Query: 105 DEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRA 164
DE V+Q + +++ F +K +ALL+V +LF D+ ++++I+ A
Sbjct: 362 DEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEA 421
Query: 165 QTLLKCERCSVLLLEDIESPVVKFT------KSFELMSPKCSADAENSFKESMEKSSYSD 218
+ L E CSV LL+ E F +S+E+ P
Sbjct: 422 RNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPA-------------------- 461
Query: 219 WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVA 278
+ IA VA+TG +NI DAY P F D +GF R++LC PI N N ++IGVA
Sbjct: 462 ---DQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVA 518
Query: 279 QVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCS 338
+++N+++G F D+ L AF I+CG+ I ++++Y +V ++ + +A +++ YH S
Sbjct: 519 ELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVS 578
Query: 339 KAEVDKFKAANIPLVSELAIDDIHFDDF-----SLDVDAMITAALRMFMELGMVQKFKID 393
E K I V+ + D +F F SL D A L M ++ + +KID
Sbjct: 579 DDEYTKLLHDGIQPVAAI---DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKID 635
Query: 394 YETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLC 453
TL R+ L V+K YR YHNW HAF+V + + + L ++EI A+ + C+C
Sbjct: 636 CPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMC 695
Query: 454 HDLDHRGTNNAFQAKSGSALAQLYGT-SATLEHHHFNHAVMILQSEGHNIFANLSSKEYS 512
HDLDHRGTNN+FQ S S LA LY + + +E HHF A+ IL + G NIF + S K+Y
Sbjct: 696 HDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQ 755
Query: 513 DLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTK 572
++ L++ ILATDL + + ++ G YD N K H + +LMT+CDL TK
Sbjct: 756 RMLDLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTK 814
Query: 573 PWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQ 632
W+ +R++AEL+ EFF QGD E+ + P + DR K +P LQ+ +++ I MP+Y+
Sbjct: 815 GWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDR-EKAYIPELQISFMEHIAMPIYK 872
Query: 633 ALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSS 671
L + K + + VA+NR W ++ K + S++
Sbjct: 873 LLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNN 911
>gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]
Length = 575
Score = 326 bits (836), Expect = 4e-89
Identities = 175/478 (36%), Positives = 266/478 (55%), Gaps = 35/478 (7%)
Query: 215 SYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNH 272
S W + + + VA +G NI +A D F + + SG+ I++VL +PI N
Sbjct: 55 SADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKE 114
Query: 273 QIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLS 332
+I+GVA NR DGKPFD+ D+ L E+ F G + NT YD++ K ++ +A D++
Sbjct: 115 EIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVL 174
Query: 333 YHATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDFSLDV 370
YH C + E+ L E A I + HF D
Sbjct: 175 YHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTE 234
Query: 371 DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAML 430
++ ++M+ ELG+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q MF +L
Sbjct: 235 LDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLL 294
Query: 431 TTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNH 490
T + T++E A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH
Sbjct: 295 MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEF 353
Query: 491 AVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG------ 544
+L E NI+ NL+ +++ ++ L+ +I+ATDL LYF++R F ++V +
Sbjct: 354 GKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDK 413
Query: 545 ----EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELK 600
EY ++I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER L
Sbjct: 414 KSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLD 473
Query: 601 LTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 658
P + DRN+ ELP+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+ L
Sbjct: 474 QQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 531
Score = 46.2 bits (108), Expect = 1e-04
Identities = 36/140 (25%), Positives = 63/140 (45%), Gaps = 8/140 (5%)
Query: 66 TGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQL 125
+G+ K++L MPI + EI+GVA N+ +G PF E DE +M+ F G ++ N
Sbjct: 97 SGWLIKNVLSMPIVNKKEEIVGVATFYNR-KDGKPFDEQDEVLMESLTQFLGWSVMNTDT 155
Query: 126 FAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERC-----SVLLLED 180
+ K R ++V L+ + D ++I + RA+ + C +L E+
Sbjct: 156 YDKMNKLENRKDIAQDMV--LYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEE 213
Query: 181 IESPVVKFTKSFELMSPKCS 200
+ P F +C+
Sbjct: 214 LPGPTTFDIYEFHFSDLECT 233
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 363 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 422
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 54 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 113
Query: 423 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 482
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 114 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 173
Query: 483 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 542
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 174 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 233
Query: 543 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 234 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 290
Query: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 658
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 291 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 346
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 363 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 422
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 54 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 113
Query: 423 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 482
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 114 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 173
Query: 483 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 542
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 174 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 233
Query: 543 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 234 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 290
Query: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 658
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 291 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 346
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 363 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 422
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 235 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 294
Query: 423 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 482
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 295 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 354
Query: 483 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 542
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 355 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 414
Query: 543 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 415 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 471
Query: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 658
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 472 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 527
>gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]
Length = 552
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 363 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 422
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 220 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 279
Query: 423 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 482
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 280 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 339
Query: 483 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 542
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 340 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 399
Query: 543 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 400 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 456
Query: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 658
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 457 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 512
>gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens]
Length = 526
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 363 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 422
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 194 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 253
Query: 423 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 482
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 254 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 313
Query: 483 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 542
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 314 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 373
Query: 543 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 374 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 430
Query: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 658
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 431 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 486
>gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 363 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 422
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 44 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 103
Query: 423 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 482
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 104 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 163
Query: 483 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 542
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 164 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 223
Query: 543 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 224 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 280
Query: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 658
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 281 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 336
>gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 363 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 422
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 54 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 113
Query: 423 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 482
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 114 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 173
Query: 483 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 542
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 174 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 233
Query: 543 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 234 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 290
Query: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 658
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 291 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 346
>gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens]
Length = 491
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 363 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 422
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 159 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 218
Query: 423 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 482
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 219 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 278
Query: 483 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 542
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 279 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 338
Query: 543 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 339 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 395
Query: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 658
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 396 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 451
>gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens]
Length = 459
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 363 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 422
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 127 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 186
Query: 423 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 482
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 187 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 246
Query: 483 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 542
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 247 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 306
Query: 543 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 307 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 363
Query: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 658
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 364 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 419
>gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 363 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 422
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 44 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 103
Query: 423 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 482
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 104 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 163
Query: 483 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 542
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 164 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 223
Query: 543 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 224 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 280
Query: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 658
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 281 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 336
>gi|48762734 phosphodiesterase 9A isoform i [Homo sapiens]
Length = 433
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 363 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 422
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 101 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 160
Query: 423 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 482
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 161 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 220
Query: 483 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 542
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 221 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 280
Query: 543 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 281 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 337
Query: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 658
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 338 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 393
>gi|48762732 phosphodiesterase 9A isoform h [Homo sapiens]
Length = 507
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 363 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 422
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 175 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 234
Query: 423 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 482
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 235 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 294
Query: 483 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 542
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 295 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 354
Query: 543 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 355 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 411
Query: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 658
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 412 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 467
>gi|48762730 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 363 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 422
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 54 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 113
Query: 423 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 482
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 114 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 173
Query: 483 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 542
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 174 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 233
Query: 543 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 234 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 290
Query: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 658
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 291 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 346
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.133 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,182,000
Number of Sequences: 37866
Number of extensions: 869192
Number of successful extensions: 2937
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2647
Number of HSP's gapped (non-prelim): 115
length of query: 683
length of database: 18,247,518
effective HSP length: 109
effective length of query: 574
effective length of database: 14,120,124
effective search space: 8104951176
effective search space used: 8104951176
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.