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Search of human proteins with 116536085
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]
(933 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens] 1867 0.0
gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens] 1254 0.0
gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens] 1147 0.0
gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens] 981 0.0
gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens] 595 e-170
gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens] 595 e-170
gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens] 595 e-170
gi|170650674 phosphodiesterase 6A [Homo sapiens] 431 e-120
gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens] 429 e-120
gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens] 429 e-120
gi|157364939 phosphodiesterase 6C [Homo sapiens] 414 e-115
gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens] 368 e-101
gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens] 368 e-101
gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens] 362 1e-99
gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens] 362 1e-99
gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens] 362 1e-99
gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens] 326 5e-89
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 159 1e-38
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 159 1e-38
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 159 1e-38
gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens] 159 1e-38
gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens] 159 1e-38
gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens] 159 1e-38
gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens] 159 1e-38
gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens] 159 1e-38
gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens] 159 1e-38
gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens] 159 1e-38
gi|48762734 phosphodiesterase 9A isoform i [Homo sapiens] 159 1e-38
gi|48762732 phosphodiesterase 9A isoform h [Homo sapiens] 159 1e-38
gi|48762730 phosphodiesterase 9A isoform g [Homo sapiens] 159 1e-38
>gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]
Length = 933
Score = 1867 bits (4837), Expect = 0.0
Identities = 933/933 (100%), Positives = 933/933 (100%)
Query: 1 MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS 60
MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS
Sbjct: 1 MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS 60
Query: 61 LAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE 120
LAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE
Sbjct: 61 LAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE 120
Query: 121 LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV 180
LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV
Sbjct: 121 LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV 180
Query: 181 NLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL 240
NLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL
Sbjct: 181 NLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL 240
Query: 241 FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP 300
FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP
Sbjct: 241 FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP 300
Query: 301 DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ 360
DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ
Sbjct: 301 DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ 360
Query: 361 MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC 420
MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC
Sbjct: 361 MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC 420
Query: 421 ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA 480
ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA
Sbjct: 421 ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA 480
Query: 481 STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD 540
STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD
Sbjct: 481 STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD 540
Query: 541 DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI 600
DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI
Sbjct: 541 DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI 600
Query: 601 PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM 660
PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM
Sbjct: 601 PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM 660
Query: 661 VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSG 720
VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSG
Sbjct: 661 VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSG 720
Query: 721 SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY 780
SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY
Sbjct: 721 SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY 780
Query: 781 FERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE 840
FERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE
Sbjct: 781 FERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE 840
Query: 841 QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT 900
QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT
Sbjct: 841 QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT 900
Query: 901 NRSKWEELHQKRLLASTASSSPASVMVAKEDRN 933
NRSKWEELHQKRLLASTASSSPASVMVAKEDRN
Sbjct: 901 NRSKWEELHQKRLLASTASSSPASVMVAKEDRN 933
>gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]
Length = 683
Score = 1254 bits (3246), Expect = 0.0
Identities = 629/630 (99%), Positives = 630/630 (100%)
Query: 304 QDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYL 363
+DRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYL
Sbjct: 54 KDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYL 113
Query: 364 PFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERC 423
PFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERC
Sbjct: 114 PFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERC 173
Query: 424 SVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTG 483
SVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTG
Sbjct: 174 SVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTG 233
Query: 484 LPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDAD 543
LPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDAD
Sbjct: 234 LPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDAD 293
Query: 544 QRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLV 603
QRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLV
Sbjct: 294 QRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLV 353
Query: 604 SELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLY 663
SELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLY
Sbjct: 354 SELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLY 413
Query: 664 HNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSAL 723
HNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSAL
Sbjct: 414 HNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSAL 473
Query: 724 AQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFER 783
AQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFER
Sbjct: 474 AQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFER 533
Query: 784 RTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGD 843
RTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGD
Sbjct: 534 RTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGD 593
Query: 844 RERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRS 903
RERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRS
Sbjct: 594 RERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRS 653
Query: 904 KWEELHQKRLLASTASSSPASVMVAKEDRN 933
KWEELHQKRLLASTASSSPASVMVAKEDRN
Sbjct: 654 KWEELHQKRLLASTASSSPASVMVAKEDRN 683
Score = 98.2 bits (243), Expect = 3e-20
Identities = 63/208 (30%), Positives = 116/208 (55%), Gaps = 16/208 (7%)
Query: 197 KKHNERQFFLELVKDISND-LDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVS 255
K++ + LE+V D+ + DL + KI+ ++ +RCS+ L+E + +
Sbjct: 131 KEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIES-PVVKFT 189
Query: 256 KFFDVHAGTPLLPCSS-TENSNEVQVP------W--GKGIIGYVGEHGETVNIPDAYQDR 306
K F++ + CS+ ENS + + W I V G VNI DAYQD
Sbjct: 190 KSFELMSPK----CSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDP 245
Query: 307 RFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFC 366
RF+ E D+++G+ +S+LC+PI +S+ +IIGVAQ +N++ +G PF + D+++ + ++ FC
Sbjct: 246 RFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL-DGKPFDDADQRLFEAFVIFC 304
Query: 367 GIAISNAQLFAASRKEYERSRALLEVVN 394
G+ I+N ++ +K + + L+V++
Sbjct: 305 GLGINNTIMYDQVKKSWAKQSVALDVLS 332
>gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]
Length = 575
Score = 1147 bits (2966), Expect = 0.0
Identities = 575/575 (100%), Positives = 575/575 (100%)
Query: 359 MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLL 418
MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLL
Sbjct: 1 MQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLL 60
Query: 419 KCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL 478
KCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL
Sbjct: 61 KCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL 120
Query: 479 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 538
VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP
Sbjct: 121 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 180
Query: 539 FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA 598
FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA
Sbjct: 181 FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA 240
Query: 599 NIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY 658
NIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY
Sbjct: 241 NIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY 300
Query: 659 RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAK 718
RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAK
Sbjct: 301 RMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAK 360
Query: 719 SGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLT 778
SGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLT
Sbjct: 361 SGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLT 420
Query: 779 LYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEF 838
LYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEF
Sbjct: 421 LYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEF 480
Query: 839 FEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSV 898
FEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSV
Sbjct: 481 FEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSV 540
Query: 899 ATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN 933
ATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN
Sbjct: 541 ATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN 575
Score = 98.2 bits (243), Expect = 3e-20
Identities = 63/208 (30%), Positives = 116/208 (55%), Gaps = 16/208 (7%)
Query: 197 KKHNERQFFLELVKDISND-LDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVS 255
K++ + LE+V D+ + DL + KI+ ++ +RCS+ L+E + +
Sbjct: 23 KEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIES-PVVKFT 81
Query: 256 KFFDVHAGTPLLPCSS-TENSNEVQVP------W--GKGIIGYVGEHGETVNIPDAYQDR 306
K F++ + CS+ ENS + + W I V G VNI DAYQD
Sbjct: 82 KSFELMSPK----CSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDP 137
Query: 307 RFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFC 366
RF+ E D+++G+ +S+LC+PI +S+ +IIGVAQ +N++ +G PF + D+++ + ++ FC
Sbjct: 138 RFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL-DGKPFDDADQRLFEAFVIFC 196
Query: 367 GIAISNAQLFAASRKEYERSRALLEVVN 394
G+ I+N ++ +K + + L+V++
Sbjct: 197 GLGINNTIMYDQVKKSWAKQSVALDVLS 224
>gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]
Length = 489
Score = 981 bits (2537), Expect = 0.0
Identities = 489/489 (100%), Positives = 489/489 (100%)
Query: 445 MSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI 504
MSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI
Sbjct: 1 MSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI 60
Query: 505 SGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMY 564
SGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMY
Sbjct: 61 SGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMY 120
Query: 565 DQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMI 624
DQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMI
Sbjct: 121 DQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMI 180
Query: 625 TAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAG 684
TAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAG
Sbjct: 181 TAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAG 240
Query: 685 FQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMI 744
FQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMI
Sbjct: 241 FQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMI 300
Query: 745 LQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHR 804
LQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHR
Sbjct: 301 LQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHR 360
Query: 805 DIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDE 864
DIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDE
Sbjct: 361 DIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDE 420
Query: 865 LPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPAS 924
LPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPAS
Sbjct: 421 LPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPAS 480
Query: 925 VMVAKEDRN 933
VMVAKEDRN
Sbjct: 481 VMVAKEDRN 489
Score = 89.0 bits (219), Expect = 2e-17
Identities = 40/105 (38%), Positives = 72/105 (68%), Gaps = 1/105 (0%)
Query: 290 VGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGA 349
V G VNI DAYQD RF+ E D+++G+ +S+LC+PI +S+ +IIGVAQ +N++ +G
Sbjct: 35 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRL-DGK 93
Query: 350 PFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVN 394
PF + D+++ + ++ FCG+ I+N ++ +K + + L+V++
Sbjct: 94 PFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLS 138
>gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]
Length = 875
Score = 595 bits (1535), Expect = e-170
Identities = 317/721 (43%), Positives = 468/721 (64%), Gaps = 27/721 (3%)
Query: 206 LELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTP 265
LELVKDIS+ LD+T+L +KI + + ++ ADR SLFLV ++ K L+S+ FDV G+
Sbjct: 153 LELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGST 212
Query: 266 LLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLC 325
L S+ N +++ W KGI+G+V GE +NI DAY+D RFN E+D++TGYKT+S+LC
Sbjct: 213 LEEVSN----NCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILC 268
Query: 326 MPIRSSDGEIIGVAQAINKIP-EGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYE 384
MPI++ E++GVAQAINK G FTE DEK YL FCGI + NAQL+ S E +
Sbjct: 269 MPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENK 328
Query: 385 RSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFEL 444
R++ LL++ + +FEEQ LE I+KKI + ++ ++C++ ++++ S F+ F +
Sbjct: 329 RNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSD--SFSSVFHM 386
Query: 445 MSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI 504
+ ++ +E IN A+ V +T P+NI D +D RF +
Sbjct: 387 ECEELEKSSDTLTREHDANK------INYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENT 440
Query: 505 SGFH---IRSVLCVPIWNSN-HQIIGVAQVLNRLDG-----KPFDDADQRLFEAFVIFCG 555
+ IRS+LC PI N +++IGV Q++N+++ KPF+ D++ EAFVIFCG
Sbjct: 441 GNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCG 500
Query: 556 LGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFK---AANIPLVSELAIDDIH 612
LGI NT MY+ V+++ AKQ V L+VLSYHA+ ++ E + + AA +P L I D
Sbjct: 501 LGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFS 560
Query: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM-VLYHNWRHAFN 671
F DF L +RMF +L +VQ F++ +E LCRW+L+V+KNYR V YHNWRHAFN
Sbjct: 561 FSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFN 620
Query: 672 VCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSA 731
Q MFA L Q+ LT++EILA+++ L HDLDHRG NN++ +S LAQLY S
Sbjct: 621 TAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSI 680
Query: 732 TLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELV 791
+EHHHF+ +MIL S G+ I + LS +EY ++++KQ+ILATDL LY +RR EFFEL+
Sbjct: 681 -MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELI 739
Query: 792 SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKL 851
K +++ + +++F +MLMTACDL A+TKPW I +++AELV +EFF+QGDRER EL +
Sbjct: 740 RKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNI 799
Query: 852 TPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQK 911
P+ + +R +K+++P +Q+ +ID+IC+ LY+AL V+ P+LD NR KW+ L ++
Sbjct: 800 EPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
Query: 912 R 912
+
Sbjct: 860 Q 860
>gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]
Length = 823
Score = 595 bits (1535), Expect = e-170
Identities = 317/721 (43%), Positives = 468/721 (64%), Gaps = 27/721 (3%)
Query: 206 LELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTP 265
LELVKDIS+ LD+T+L +KI + + ++ ADR SLFLV ++ K L+S+ FDV G+
Sbjct: 101 LELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGST 160
Query: 266 LLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLC 325
L S+ N +++ W KGI+G+V GE +NI DAY+D RFN E+D++TGYKT+S+LC
Sbjct: 161 LEEVSN----NCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILC 216
Query: 326 MPIRSSDGEIIGVAQAINKIP-EGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYE 384
MPI++ E++GVAQAINK G FTE DEK YL FCGI + NAQL+ S E +
Sbjct: 217 MPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENK 276
Query: 385 RSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFEL 444
R++ LL++ + +FEEQ LE I+KKI + ++ ++C++ ++++ S F+ F +
Sbjct: 277 RNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSD--SFSSVFHM 334
Query: 445 MSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI 504
+ ++ +E IN A+ V +T P+NI D +D RF +
Sbjct: 335 ECEELEKSSDTLTREHDANK------INYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENT 388
Query: 505 SGFH---IRSVLCVPIWNSN-HQIIGVAQVLNRLDG-----KPFDDADQRLFEAFVIFCG 555
+ IRS+LC PI N +++IGV Q++N+++ KPF+ D++ EAFVIFCG
Sbjct: 389 GNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCG 448
Query: 556 LGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFK---AANIPLVSELAIDDIH 612
LGI NT MY+ V+++ AKQ V L+VLSYHA+ ++ E + + AA +P L I D
Sbjct: 449 LGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFS 508
Query: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM-VLYHNWRHAFN 671
F DF L +RMF +L +VQ F++ +E LCRW+L+V+KNYR V YHNWRHAFN
Sbjct: 509 FSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFN 568
Query: 672 VCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSA 731
Q MFA L Q+ LT++EILA+++ L HDLDHRG NN++ +S LAQLY S
Sbjct: 569 TAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSI 628
Query: 732 TLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELV 791
+EHHHF+ +MIL S G+ I + LS +EY ++++KQ+ILATDL LY +RR EFFEL+
Sbjct: 629 -MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELI 687
Query: 792 SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKL 851
K +++ + +++F +MLMTACDL A+TKPW I +++AELV +EFF+QGDRER EL +
Sbjct: 688 RKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNI 747
Query: 852 TPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQK 911
P+ + +R +K+++P +Q+ +ID+IC+ LY+AL V+ P+LD NR KW+ L ++
Sbjct: 748 EPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 807
Query: 912 R 912
+
Sbjct: 808 Q 808
>gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]
Length = 833
Score = 595 bits (1535), Expect = e-170
Identities = 317/721 (43%), Positives = 468/721 (64%), Gaps = 27/721 (3%)
Query: 206 LELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTP 265
LELVKDIS+ LD+T+L +KI + + ++ ADR SLFLV ++ K L+S+ FDV G+
Sbjct: 111 LELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGST 170
Query: 266 LLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLC 325
L S+ N +++ W KGI+G+V GE +NI DAY+D RFN E+D++TGYKT+S+LC
Sbjct: 171 LEEVSN----NCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILC 226
Query: 326 MPIRSSDGEIIGVAQAINKIP-EGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYE 384
MPI++ E++GVAQAINK G FTE DEK YL FCGI + NAQL+ S E +
Sbjct: 227 MPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENK 286
Query: 385 RSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFEL 444
R++ LL++ + +FEEQ LE I+KKI + ++ ++C++ ++++ S F+ F +
Sbjct: 287 RNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSD--SFSSVFHM 344
Query: 445 MSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI 504
+ ++ +E IN A+ V +T P+NI D +D RF +
Sbjct: 345 ECEELEKSSDTLTREHDANK------INYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENT 398
Query: 505 SGFH---IRSVLCVPIWNSN-HQIIGVAQVLNRLDG-----KPFDDADQRLFEAFVIFCG 555
+ IRS+LC PI N +++IGV Q++N+++ KPF+ D++ EAFVIFCG
Sbjct: 399 GNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCG 458
Query: 556 LGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFK---AANIPLVSELAIDDIH 612
LGI NT MY+ V+++ AKQ V L+VLSYHA+ ++ E + + AA +P L I D
Sbjct: 459 LGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFS 518
Query: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM-VLYHNWRHAFN 671
F DF L +RMF +L +VQ F++ +E LCRW+L+V+KNYR V YHNWRHAFN
Sbjct: 519 FSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFN 578
Query: 672 VCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSA 731
Q MFA L Q+ LT++EILA+++ L HDLDHRG NN++ +S LAQLY S
Sbjct: 579 TAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSI 638
Query: 732 TLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELV 791
+EHHHF+ +MIL S G+ I + LS +EY ++++KQ+ILATDL LY +RR EFFEL+
Sbjct: 639 -MEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELI 697
Query: 792 SKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKL 851
K +++ + +++F +MLMTACDL A+TKPW I +++AELV +EFF+QGDRER EL +
Sbjct: 698 RKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNI 757
Query: 852 TPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQK 911
P+ + +R +K+++P +Q+ +ID+IC+ LY+AL V+ P+LD NR KW+ L ++
Sbjct: 758 EPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 817
Query: 912 R 912
+
Sbjct: 818 Q 818
>gi|170650674 phosphodiesterase 6A [Homo sapiens]
Length = 860
Score = 431 bits (1109), Expect = e-120
Identities = 248/766 (32%), Positives = 404/766 (52%), Gaps = 68/766 (8%)
Query: 201 ERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDV 260
E + +L++D +L + ++ +C ++ ADR SLF+ G L ++ F+V
Sbjct: 57 ESEIIFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYR-TRNGIAELATRLFNV 115
Query: 261 HAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKT 320
H L C + E+ P GI+G+V + N+P+ +D F D +D LT YKT
Sbjct: 116 HKDAVLEDCLVMPDQ-EIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKT 174
Query: 321 KSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASR 380
K++L PI + +++ + A+NK+ +G+ FT+ DE+++ YL F + + L
Sbjct: 175 KNILASPIMNGK-DVVAIIMAVNKV-DGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHN 232
Query: 381 KEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTK 440
E R + LL + +FEE TD+E+ K ++ + L C+R SV LL+ + K +
Sbjct: 233 CETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLD-----MTKQKE 287
Query: 441 SFELM-----------SPKCSADAENSFKESMEKSSYSD-------------WLINNSIA 476
F++ P+ E +F + ++ + W + + +
Sbjct: 288 FFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLP 347
Query: 477 ELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNHQIIGVAQVLNRL 534
VA GL NI +A + F + + + SG+ I++VL +PI N +I+GVA NR
Sbjct: 348 AYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRK 407
Query: 535 DGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDK 594
DGKPFD+ D+ L E+ F G + N Y+ + K ++ + D++ YH C E+ K
Sbjct: 408 DGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQK 467
Query: 595 FKA----------------------ANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFM 632
A +P + I+ HF D L ++ ++M+
Sbjct: 468 ILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYY 527
Query: 633 ELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEV 692
EL +V KF I E L R++ ++ K YR + YHNWRH FNV Q MF++L T + T++
Sbjct: 528 ELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDL 587
Query: 693 EILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNI 752
E LA++ CHD+DHRGTNN +Q KS + LA+L+G S+ LE HH +L+ E NI
Sbjct: 588 EALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKTLLRDESLNI 646
Query: 753 FANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS-----KGEYDWN-----IKN 802
F NL+ +++ + ++ +I+ATDL LYF++RT F ++V + E +W +
Sbjct: 647 FQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQT 706
Query: 803 HRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRK 862
++I +M+MTACDL A+TKPWE+ QVA LV +EF+EQGD ER L+ P + DRN+
Sbjct: 707 RKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKA 766
Query: 863 DELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 908
DELP+LQ+ +ID +C +Y+ + + ++ PMLD + NR +W+ L
Sbjct: 767 DELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKAL 812
>gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]
Length = 853
Score = 429 bits (1102), Expect = e-120
Identities = 258/763 (33%), Positives = 402/763 (52%), Gaps = 62/763 (8%)
Query: 201 ERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDV 260
E LELV+D+ +++ + +K+L +C ++ ADRCSLF+ G L ++ F V
Sbjct: 55 ESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYR-QRNGVAELATRLFSV 113
Query: 261 HAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKT 320
+ L C +S E+ P G++G+V + + VN+ D + F+ D+LT YKT
Sbjct: 114 QPDSVLEDCLVPPDS-EIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKT 172
Query: 321 KSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASR 380
K++L PI + +++ V A+NK+ G FT +DE V YL F + + L
Sbjct: 173 KNMLATPIMNGK-DVVAVIMAVNKL-NGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHN 230
Query: 381 KEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLE--------DIE 432
E R + LL N +FEE TD+E+ K + + L CER SV LL+ D+
Sbjct: 231 CETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVW 290
Query: 433 SPVVKFTKSFELMSPKCSADAENSF----------KESME---KSSYSDWLINNSIAELV 479
S ++ ++ + P+ E F KE ++ S W + + + V
Sbjct: 291 SVLMGESQPYS--GPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYV 348
Query: 480 ASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK 537
A +G NI +A D F + + SG+ I++VL +PI N +I+GVA NR DGK
Sbjct: 349 AESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGK 408
Query: 538 PFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKA 597
PFD+ D+ L E+ F G + NT YD++ K ++ +A D++ YH C + E+
Sbjct: 409 PFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILP 468
Query: 598 ANIPLVSELA----------------------IDDIHFDDFSLDVDAMITAALRMFMELG 635
L E A I + HF D ++ ++M+ ELG
Sbjct: 469 TRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELG 528
Query: 636 MVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEIL 695
+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q MF +L T + T++E
Sbjct: 529 VVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAF 588
Query: 696 AVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFAN 755
A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH +L E NI+ N
Sbjct: 589 AMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQN 647
Query: 756 LSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG----------EYDWNIKNHRD 805
L+ +++ ++ L+ +I+ATDL LYF++R F ++V + EY ++
Sbjct: 648 LNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKE 707
Query: 806 IFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDEL 865
I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER L P + DRN+ EL
Sbjct: 708 IVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAEL 767
Query: 866 PRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 908
P+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+ L
Sbjct: 768 PKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 810
>gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]
Length = 854
Score = 429 bits (1102), Expect = e-120
Identities = 258/763 (33%), Positives = 402/763 (52%), Gaps = 62/763 (8%)
Query: 201 ERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDV 260
E LELV+D+ +++ + +K+L +C ++ ADRCSLF+ G L ++ F V
Sbjct: 55 ESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYR-QRNGVAELATRLFSV 113
Query: 261 HAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKT 320
+ L C +S E+ P G++G+V + + VN+ D + F+ D+LT YKT
Sbjct: 114 QPDSVLEDCLVPPDS-EIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKT 172
Query: 321 KSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASR 380
K++L PI + +++ V A+NK+ G FT +DE V YL F + + L
Sbjct: 173 KNMLATPIMNGK-DVVAVIMAVNKL-NGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHN 230
Query: 381 KEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLE--------DIE 432
E R + LL N +FEE TD+E+ K + + L CER SV LL+ D+
Sbjct: 231 CETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVW 290
Query: 433 SPVVKFTKSFELMSPKCSADAENSF----------KESME---KSSYSDWLINNSIAELV 479
S ++ ++ + P+ E F KE ++ S W + + + V
Sbjct: 291 SVLMGESQPYS--GPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYV 348
Query: 480 ASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK 537
A +G NI +A D F + + SG+ I++VL +PI N +I+GVA NR DGK
Sbjct: 349 AESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGK 408
Query: 538 PFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKA 597
PFD+ D+ L E+ F G + NT YD++ K ++ +A D++ YH C + E+
Sbjct: 409 PFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILP 468
Query: 598 ANIPLVSELA----------------------IDDIHFDDFSLDVDAMITAALRMFMELG 635
L E A I + HF D ++ ++M+ ELG
Sbjct: 469 TRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELG 528
Query: 636 MVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEIL 695
+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q MF +L T + T++E
Sbjct: 529 VVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAF 588
Query: 696 AVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFAN 755
A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH +L E NI+ N
Sbjct: 589 AMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQN 647
Query: 756 LSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG----------EYDWNIKNHRD 805
L+ +++ ++ L+ +I+ATDL LYF++R F ++V + EY ++
Sbjct: 648 LNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKE 707
Query: 806 IFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDEL 865
I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER L P + DRN+ EL
Sbjct: 708 IVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAEL 767
Query: 866 PRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 908
P+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+ L
Sbjct: 768 PKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 810
>gi|157364939 phosphodiesterase 6C [Homo sapiens]
Length = 858
Score = 414 bits (1064), Expect = e-115
Identities = 249/736 (33%), Positives = 387/736 (52%), Gaps = 69/736 (9%)
Query: 232 MVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENS-----NEVQVPWGKGI 286
++ ADRCS+FL + G + S+ DV P S E++ EV P GI
Sbjct: 90 LLQADRCSMFLCR-SRNGIPEVASRLLDV------TPTSKFEDNLVGPDKEVVFPLDIGI 142
Query: 287 IGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIP 346
+G+ +T N+PD ++ F+D +DK TGY TK+LL PI E++ V A+NK+
Sbjct: 143 VGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGK-EVLAVIMAVNKV- 200
Query: 347 EGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKI 406
+ F++ DE+V YL F I + E RS+ L+ N +FEE TD+E+
Sbjct: 201 NASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQ 260
Query: 407 VKKIMHRAQTLLKCERCSVLLL------EDIESPVVKFTKSFELMSPKCSADAENSFKES 460
K ++ ++ L CER S+ LL E + +K + PK E +F +
Sbjct: 261 FHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKI 320
Query: 461 MEKSSYSD-------------WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--S 505
++ + W + + + VA G N+ +A D F + + +
Sbjct: 321 IDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDET 380
Query: 506 GFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYD 565
G+ I++VL +PI N I+GVA NR DGKPFD+ D+ + E F G + NT YD
Sbjct: 381 GWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYD 440
Query: 566 QVKKSWAKQSVALDVLSYHATCSKAEVDKF----KAANIPLVSELA-------------- 607
++ K ++ +A ++L + E+ + N+ ++ +
Sbjct: 441 KMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPD 500
Query: 608 -----IDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVL 662
+ + F DF L +I +R+F E+ +V+KFK+ E L RW+ TVRK YR V
Sbjct: 501 PRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVT 560
Query: 663 YHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSA 722
YHNWRH FNV Q MF +L T + T++E A++ CHD+DHRGTNN +Q KS S
Sbjct: 561 YHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSP 620
Query: 723 LAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFE 782
LA+L+G S+ LE HH ++ +LQ E NIF NL+ +++ ++ L + +I+ATDL LYF+
Sbjct: 621 LARLHG-SSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFK 679
Query: 783 RRTEFFELVSKGE----------YDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAE 832
+RT F ++V E Y ++I +M+MTACDL A+TKPWE+ QVA
Sbjct: 680 KRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVAL 739
Query: 833 LVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLK 892
+V +EF+EQGD ER L+ P + DRN++DELP+LQ+ +ID +C +Y+ + + ++
Sbjct: 740 MVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEIT 799
Query: 893 PMLDSVATNRSKWEEL 908
PML + NR +W+ L
Sbjct: 800 PMLSGLQNNRVEWKSL 815
>gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]
Length = 779
Score = 368 bits (944), Expect = e-101
Identities = 215/650 (33%), Positives = 356/650 (54%), Gaps = 19/650 (2%)
Query: 283 GKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAI 342
G + YV + +T+ + D D RF +G + +S+LC+PI ++ G++IG+ +
Sbjct: 148 GTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY 207
Query: 343 NKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTD 402
+ A F ++V L + +AI Q+ K+ E + LL+V F+
Sbjct: 208 RHWGKEA-FCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVA 266
Query: 403 LEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESME 462
++ +++ IM A+ L+ +RC++ ++ K+ EL S E K +
Sbjct: 267 IDSLLEHIMIYAKNLVNADRCALFQVDH---------KNKELYSDLFDIGEEKEGKPVFK 317
Query: 463 KSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNH 522
K+ + I IA VA TG +NI DAY DPRF+ E D +G+ R++LC+PI S
Sbjct: 318 KTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV-SRG 376
Query: 523 QIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLS 582
+IGV Q++N++ G F D+ F+ F +FC L ++ MY +++ S V ++ LS
Sbjct: 377 SVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLS 436
Query: 583 YHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKI 642
YH+ C+ E +P+ I+ HFD + + + ++M
Sbjct: 437 YHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFE---NMWPGIFVYMVHRSCGTSCF 493
Query: 643 DYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCL 702
+ E LCR++++V+KNYR V YHNW+HA V M+A+L + T++E +++ CL
Sbjct: 494 ELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACL 551
Query: 703 CHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYS 762
CHDLDHRG +N++ K LA LY TS T+E HHF+ V ILQ EGHNIF+ LSS EY
Sbjct: 552 CHDLDHRGFSNSYLQKFDHPLAALYSTS-TMEQHHFSQTVSILQLEGHNIFSTLSSSEYE 610
Query: 763 DLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTK 822
++++++++I+ATDL LYF R + E+ G + N ++HRD ++MTACDL +VTK
Sbjct: 611 QVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTK 670
Query: 823 PWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQ 882
W +++ A + +EF+ +GD E +L + P + DR++KDE+P+ QL + +++ +P Y
Sbjct: 671 LWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYT 729
Query: 883 ALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASS-SPASVMVAKED 931
L ++ +P+L + N S+WE++ + A+ SS S A A ED
Sbjct: 730 TLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED 779
Score = 114 bits (284), Expect = 6e-25
Identities = 71/184 (38%), Positives = 104/184 (56%), Gaps = 14/184 (7%)
Query: 197 KKHNERQFFLELVKD-ISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVS 255
K+ F L++ K N + + SL I+I+ +V+ADRC+LF V+ K L S
Sbjct: 245 KQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHK---NKELYS 301
Query: 256 KFFDV---HAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEI 312
FD+ G P+ + + E++ KGI G V GE +NIPDAY D RFN E+
Sbjct: 302 DLFDIGEEKEGKPVF-----KKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREV 356
Query: 313 DKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISN 372
D TGY T+++LCMPI S G +IGV Q +NKI G+ F++ DE +M+ FC +A+
Sbjct: 357 DLYTGYTTRNILCMPI-VSRGSVIGVVQMVNKI-SGSAFSKTDENNFKMFAVFCALALHC 414
Query: 373 AQLF 376
A ++
Sbjct: 415 ANMY 418
Score = 32.0 bits (71), Expect = 2.8
Identities = 11/32 (34%), Positives = 21/32 (65%)
Query: 10 EVETFLDRHPELFEDYLMRKGKQEMVEKWLQR 41
+V+ +L HP++ ++++ E VEKWL+R
Sbjct: 18 KVKAYLSLHPQVLDEFVSESVSAETVEKWLKR 49
>gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]
Length = 789
Score = 368 bits (944), Expect = e-101
Identities = 215/650 (33%), Positives = 356/650 (54%), Gaps = 19/650 (2%)
Query: 283 GKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAI 342
G + YV + +T+ + D D RF +G + +S+LC+PI ++ G++IG+ +
Sbjct: 158 GTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELY 217
Query: 343 NKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTD 402
+ A F ++V L + +AI Q+ K+ E + LL+V F+
Sbjct: 218 RHWGKEA-FCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVA 276
Query: 403 LEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESME 462
++ +++ IM A+ L+ +RC++ ++ K+ EL S E K +
Sbjct: 277 IDSLLEHIMIYAKNLVNADRCALFQVDH---------KNKELYSDLFDIGEEKEGKPVFK 327
Query: 463 KSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNH 522
K+ + I IA VA TG +NI DAY DPRF+ E D +G+ R++LC+PI S
Sbjct: 328 KTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIV-SRG 386
Query: 523 QIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLS 582
+IGV Q++N++ G F D+ F+ F +FC L ++ MY +++ S V ++ LS
Sbjct: 387 SVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLS 446
Query: 583 YHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKI 642
YH+ C+ E +P+ I+ HFD + + + ++M
Sbjct: 447 YHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFE---NMWPGIFVYMVHRSCGTSCF 503
Query: 643 DYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCL 702
+ E LCR++++V+KNYR V YHNW+HA V M+A+L + T++E +++ CL
Sbjct: 504 ELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACL 561
Query: 703 CHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYS 762
CHDLDHRG +N++ K LA LY TS T+E HHF+ V ILQ EGHNIF+ LSS EY
Sbjct: 562 CHDLDHRGFSNSYLQKFDHPLAALYSTS-TMEQHHFSQTVSILQLEGHNIFSTLSSSEYE 620
Query: 763 DLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTK 822
++++++++I+ATDL LYF R + E+ G + N ++HRD ++MTACDL +VTK
Sbjct: 621 QVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTK 680
Query: 823 PWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQ 882
W +++ A + +EF+ +GD E +L + P + DR++KDE+P+ QL + +++ +P Y
Sbjct: 681 LWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYT 739
Query: 883 ALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASS-SPASVMVAKED 931
L ++ +P+L + N S+WE++ + A+ SS S A A ED
Sbjct: 740 TLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED 789
Score = 114 bits (284), Expect = 6e-25
Identities = 71/184 (38%), Positives = 104/184 (56%), Gaps = 14/184 (7%)
Query: 197 KKHNERQFFLELVKD-ISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVS 255
K+ F L++ K N + + SL I+I+ +V+ADRC+LF V+ K L S
Sbjct: 255 KQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHK---NKELYS 311
Query: 256 KFFDV---HAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEI 312
FD+ G P+ + + E++ KGI G V GE +NIPDAY D RFN E+
Sbjct: 312 DLFDIGEEKEGKPVF-----KKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREV 366
Query: 313 DKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISN 372
D TGY T+++LCMPI S G +IGV Q +NKI G+ F++ DE +M+ FC +A+
Sbjct: 367 DLYTGYTTRNILCMPI-VSRGSVIGVVQMVNKI-SGSAFSKTDENNFKMFAVFCALALHC 424
Query: 373 AQLF 376
A ++
Sbjct: 425 ANMY 428
Score = 32.0 bits (71), Expect = 2.8
Identities = 11/32 (34%), Positives = 21/32 (65%)
Query: 10 EVETFLDRHPELFEDYLMRKGKQEMVEKWLQR 41
+V+ +L HP++ ++++ E VEKWL+R
Sbjct: 28 KVKAYLSLHPQVLDEFVSESVSAETVEKWLKR 59
>gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]
Length = 932
Score = 362 bits (928), Expect = 1e-99
Identities = 229/722 (31%), Positives = 368/722 (50%), Gaps = 64/722 (8%)
Query: 215 DLDLTSLSYKILIFVCLMVDADRCSLFLV--EGAAAGKKTLVSKFFDVHAGTPLLPCSST 272
DLD +SL K+L ++ A RC L LV + K + K PL C
Sbjct: 230 DLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGC--- 286
Query: 273 ENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRS-S 331
+G V E +++ + D + ++ + G + +++LC+P+ S +
Sbjct: 287 --------------LGQVVEDKKSIQLKDLTSEDV--QQLQSMLGCELQAMLCVPVISRA 330
Query: 332 DGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLE 391
+++ +A A NK+ EG FT++DE V+Q + +++ F +K +ALL+
Sbjct: 331 TDQVVALACAFNKL-EGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQ 389
Query: 392 VVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFT------KSFELM 445
V +LF D+ ++++I+ A+ L E CSV LL+ E F +S+E+
Sbjct: 390 VAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIR 449
Query: 446 SPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQIS 505
P + IA VA+TG +NI DAY P F D +
Sbjct: 450 IPA-----------------------DQGIAGHVATTGQILNIPDAYAHPLFYRGVDDST 486
Query: 506 GFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYD 565
GF R++LC PI N N ++IGVA+++N+++G F D+ L AF I+CG+ I ++++Y
Sbjct: 487 GFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYK 546
Query: 566 QVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDF-----SLDV 620
+V ++ + +A +++ YH S E K I V+ + D +F F SL
Sbjct: 547 KVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAI---DSNFASFTYTPRSLPE 603
Query: 621 DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAML 680
D A L M ++ + +KID TL R+ L V+K YR YHNW HAF+V + +
Sbjct: 604 DDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLY 663
Query: 681 TTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGT-SATLEHHHFN 739
+ L ++EI A+ + C+CHDLDHRGTNN+FQ S S LA LY + + +E HHF
Sbjct: 664 KNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFA 723
Query: 740 HAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWN 799
A+ IL + G NIF + S K+Y ++ L++ ILATDL + + ++ G YD N
Sbjct: 724 QAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRN 782
Query: 800 IKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDR 859
K H + +LMT+CDL TK W+ +R++AEL+ EFF QGD E+ + P + DR
Sbjct: 783 NKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDR 841
Query: 860 NRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTAS 919
K +P LQ+ +++ I MP+Y+ L + K + + VA+NR W ++ K + S
Sbjct: 842 -EKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPS 900
Query: 920 SS 921
++
Sbjct: 901 NN 902
>gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]
Length = 934
Score = 362 bits (928), Expect = 1e-99
Identities = 229/722 (31%), Positives = 368/722 (50%), Gaps = 64/722 (8%)
Query: 215 DLDLTSLSYKILIFVCLMVDADRCSLFLV--EGAAAGKKTLVSKFFDVHAGTPLLPCSST 272
DLD +SL K+L ++ A RC L LV + K + K PL C
Sbjct: 232 DLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGC--- 288
Query: 273 ENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRS-S 331
+G V E +++ + D + ++ + G + +++LC+P+ S +
Sbjct: 289 --------------LGQVVEDKKSIQLKDLTSEDV--QQLQSMLGCELQAMLCVPVISRA 332
Query: 332 DGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLE 391
+++ +A A NK+ EG FT++DE V+Q + +++ F +K +ALL+
Sbjct: 333 TDQVVALACAFNKL-EGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQ 391
Query: 392 VVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFT------KSFELM 445
V +LF D+ ++++I+ A+ L E CSV LL+ E F +S+E+
Sbjct: 392 VAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIR 451
Query: 446 SPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQIS 505
P + IA VA+TG +NI DAY P F D +
Sbjct: 452 IPA-----------------------DQGIAGHVATTGQILNIPDAYAHPLFYRGVDDST 488
Query: 506 GFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYD 565
GF R++LC PI N N ++IGVA+++N+++G F D+ L AF I+CG+ I ++++Y
Sbjct: 489 GFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYK 548
Query: 566 QVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDF-----SLDV 620
+V ++ + +A +++ YH S E K I V+ + D +F F SL
Sbjct: 549 KVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAI---DSNFASFTYTPRSLPE 605
Query: 621 DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAML 680
D A L M ++ + +KID TL R+ L V+K YR YHNW HAF+V + +
Sbjct: 606 DDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLY 665
Query: 681 TTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGT-SATLEHHHFN 739
+ L ++EI A+ + C+CHDLDHRGTNN+FQ S S LA LY + + +E HHF
Sbjct: 666 KNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFA 725
Query: 740 HAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWN 799
A+ IL + G NIF + S K+Y ++ L++ ILATDL + + ++ G YD N
Sbjct: 726 QAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRN 784
Query: 800 IKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDR 859
K H + +LMT+CDL TK W+ +R++AEL+ EFF QGD E+ + P + DR
Sbjct: 785 NKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDR 843
Query: 860 NRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTAS 919
K +P LQ+ +++ I MP+Y+ L + K + + VA+NR W ++ K + S
Sbjct: 844 -EKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPS 902
Query: 920 SS 921
++
Sbjct: 903 NN 904
>gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]
Length = 941
Score = 362 bits (928), Expect = 1e-99
Identities = 229/722 (31%), Positives = 368/722 (50%), Gaps = 64/722 (8%)
Query: 215 DLDLTSLSYKILIFVCLMVDADRCSLFLV--EGAAAGKKTLVSKFFDVHAGTPLLPCSST 272
DLD +SL K+L ++ A RC L LV + K + K PL C
Sbjct: 239 DLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGC--- 295
Query: 273 ENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRS-S 331
+G V E +++ + D + ++ + G + +++LC+P+ S +
Sbjct: 296 --------------LGQVVEDKKSIQLKDLTSEDV--QQLQSMLGCELQAMLCVPVISRA 339
Query: 332 DGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLE 391
+++ +A A NK+ EG FT++DE V+Q + +++ F +K +ALL+
Sbjct: 340 TDQVVALACAFNKL-EGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQ 398
Query: 392 VVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFT------KSFELM 445
V +LF D+ ++++I+ A+ L E CSV LL+ E F +S+E+
Sbjct: 399 VAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIR 458
Query: 446 SPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQIS 505
P + IA VA+TG +NI DAY P F D +
Sbjct: 459 IPA-----------------------DQGIAGHVATTGQILNIPDAYAHPLFYRGVDDST 495
Query: 506 GFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYD 565
GF R++LC PI N N ++IGVA+++N+++G F D+ L AF I+CG+ I ++++Y
Sbjct: 496 GFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYK 555
Query: 566 QVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDF-----SLDV 620
+V ++ + +A +++ YH S E K I V+ + D +F F SL
Sbjct: 556 KVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAI---DSNFASFTYTPRSLPE 612
Query: 621 DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAML 680
D A L M ++ + +KID TL R+ L V+K YR YHNW HAF+V + +
Sbjct: 613 DDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLY 672
Query: 681 TTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGT-SATLEHHHFN 739
+ L ++EI A+ + C+CHDLDHRGTNN+FQ S S LA LY + + +E HHF
Sbjct: 673 KNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFA 732
Query: 740 HAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWN 799
A+ IL + G NIF + S K+Y ++ L++ ILATDL + + ++ G YD N
Sbjct: 733 QAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRN 791
Query: 800 IKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDR 859
K H + +LMT+CDL TK W+ +R++AEL+ EFF QGD E+ + P + DR
Sbjct: 792 NKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDR 850
Query: 860 NRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTAS 919
K +P LQ+ +++ I MP+Y+ L + K + + VA+NR W ++ K + S
Sbjct: 851 -EKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPS 909
Query: 920 SS 921
++
Sbjct: 910 NN 911
>gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]
Length = 575
Score = 326 bits (836), Expect = 5e-89
Identities = 175/478 (36%), Positives = 266/478 (55%), Gaps = 35/478 (7%)
Query: 465 SYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNH 522
S W + + + VA +G NI +A D F + + SG+ I++VL +PI N
Sbjct: 55 SADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKE 114
Query: 523 QIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLS 582
+I+GVA NR DGKPFD+ D+ L E+ F G + NT YD++ K ++ +A D++
Sbjct: 115 EIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVL 174
Query: 583 YHATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDFSLDV 620
YH C + E+ L E A I + HF D
Sbjct: 175 YHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTE 234
Query: 621 DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAML 680
++ ++M+ ELG+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q MF +L
Sbjct: 235 LDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLL 294
Query: 681 TTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNH 740
T + T++E A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH
Sbjct: 295 MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEF 353
Query: 741 AVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG------ 794
+L E NI+ NL+ +++ ++ L+ +I+ATDL LYF++R F ++V +
Sbjct: 354 GKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDK 413
Query: 795 ----EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELK 850
EY ++I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER L
Sbjct: 414 KSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLD 473
Query: 851 LTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 908
P + DRN+ ELP+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+ L
Sbjct: 474 QQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 531
Score = 56.6 bits (135), Expect = 1e-07
Identities = 47/173 (27%), Positives = 77/173 (44%), Gaps = 10/173 (5%)
Query: 285 GIIGYVGEHGETVNIPDAYQDRRFNDEIDKL--TGYKTKSLLCMPIRSSDGEIIGVAQAI 342
G+ YV E G NI +A D F + L +G+ K++L MPI + EI+GVA
Sbjct: 64 GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 123
Query: 343 NKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTD 402
N+ +G PF E DE +M+ F G ++ N + K R ++V L+ + D
Sbjct: 124 NR-KDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMV--LYHVKCD 180
Query: 403 LEKIVKKIMHRAQTLLKCERC-----SVLLLEDIESPVVKFTKSFELMSPKCS 450
++I + RA+ + C +L E++ P F +C+
Sbjct: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECT 233
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 672
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 54 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 113
Query: 673 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 732
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 114 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 173
Query: 733 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 792
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 174 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 233
Query: 793 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 852
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 234 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 290
Query: 853 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 908
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 291 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 346
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 672
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 54 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 113
Query: 673 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 732
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 114 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 173
Query: 733 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 792
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 174 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 233
Query: 793 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 852
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 234 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 290
Query: 853 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 908
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 291 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 346
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 672
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 235 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 294
Query: 673 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 732
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 295 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 354
Query: 733 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 792
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 355 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 414
Query: 793 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 852
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 415 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 471
Query: 853 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 908
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 472 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 527
>gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]
Length = 552
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 672
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 220 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 279
Query: 673 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 732
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 280 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 339
Query: 733 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 792
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 340 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 399
Query: 793 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 852
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 400 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 456
Query: 853 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 908
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 457 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 512
>gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens]
Length = 526
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 672
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 194 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 253
Query: 673 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 732
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 254 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 313
Query: 733 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 792
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 314 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 373
Query: 793 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 852
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 374 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 430
Query: 853 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 908
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 431 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 486
>gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 672
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 44 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 103
Query: 673 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 732
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 104 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 163
Query: 733 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 792
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 164 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 223
Query: 793 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 852
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 224 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 280
Query: 853 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 908
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 281 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 336
>gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 672
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 54 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 113
Query: 673 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 732
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 114 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 173
Query: 733 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 792
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 174 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 233
Query: 793 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 852
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 234 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 290
Query: 853 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 908
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 291 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 346
>gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens]
Length = 491
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 672
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 159 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 218
Query: 673 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 732
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 219 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 278
Query: 733 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 792
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 279 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 338
Query: 793 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 852
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 339 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 395
Query: 853 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 908
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 396 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 451
>gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens]
Length = 459
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 672
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 127 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 186
Query: 673 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 732
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 187 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 246
Query: 733 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 792
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 247 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 306
Query: 793 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 852
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 307 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 363
Query: 853 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 908
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 364 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 419
>gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 672
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 44 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 103
Query: 673 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 732
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 104 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 163
Query: 733 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 792
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 164 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 223
Query: 793 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 852
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 224 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 280
Query: 853 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 908
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 281 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 336
>gi|48762734 phosphodiesterase 9A isoform i [Homo sapiens]
Length = 433
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 672
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 101 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 160
Query: 673 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 732
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 161 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 220
Query: 733 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 792
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 221 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 280
Query: 793 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 852
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 281 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 337
Query: 853 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 908
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 338 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 393
>gi|48762732 phosphodiesterase 9A isoform h [Homo sapiens]
Length = 507
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 672
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 175 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 234
Query: 673 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 732
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 235 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 294
Query: 733 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 792
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 295 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 354
Query: 793 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 852
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 355 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 411
Query: 853 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 908
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 412 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 467
>gi|48762730 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 159 bits (401), Expect = 1e-38
Identities = 90/297 (30%), Positives = 161/297 (54%), Gaps = 5/297 (1%)
Query: 613 FDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNV 672
FD + + + M++ M+ +LG+V+ F I+ TL RWL V NYR +HN+RH F V
Sbjct: 54 FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV 113
Query: 673 CQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSAT 732
Q+M++M+ Q+ ++ +IL ++ +CHDLDH G NN +Q + + LA Y +
Sbjct: 114 AQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISP 173
Query: 733 LEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS 792
LE+HH A IL NIF+N+ + + Q + ILATD+ + E F E +
Sbjct: 174 LENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME 233
Query: 793 KGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 852
+D++ + H + + +L+ CD+ +P E++ + + E+F Q DRE+ E L
Sbjct: 234 --NFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE-GLP 290
Query: 853 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP-MLDSVATNRSKWEEL 908
+ DR++ + Q+ +I + +P+++ + K+ ++ ML + +R ++EEL
Sbjct: 291 VAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL 346
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,805,278
Number of Sequences: 37866
Number of extensions: 1559646
Number of successful extensions: 7291
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 86
Number of HSP's successfully gapped in prelim test: 100
Number of HSP's that attempted gapping in prelim test: 6493
Number of HSP's gapped (non-prelim): 530
length of query: 933
length of database: 18,247,518
effective HSP length: 112
effective length of query: 821
effective length of database: 14,006,526
effective search space: 11499357846
effective search space used: 11499357846
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.