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Search of human proteins with 11641261
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo
sapiens]
(960 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194306629 endoplasmic reticulum aminopeptidase 2 [Homo sapiens] 1950 0.0
gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo sapiens] 1950 0.0
gi|94818891 type 1 tumor necrosis factor receptor shedding amino... 967 0.0
gi|94818901 type 1 tumor necrosis factor receptor shedding amino... 967 0.0
gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo sapiens] 767 0.0
gi|61742775 leucyl/cystinyl aminopeptidase isoform 2 [Homo sapiens] 767 0.0
gi|132814467 glutamyl aminopeptidase [Homo sapiens] 538 e-153
gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo ... 495 e-140
gi|157266300 membrane alanine aminopeptidase precursor [Homo sap... 459 e-129
gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens] 450 e-126
gi|194239713 laeverin [Homo sapiens] 375 e-103
gi|40316915 arginyl aminopeptidase [Homo sapiens] 88 4e-17
gi|4505029 leukotriene A4 hydrolase [Homo sapiens] 82 3e-15
gi|54020718 arginyl aminopeptidase (aminopeptidase B)-like 1 [Ho... 72 2e-12
gi|4507347 TBP-associated factor 2 [Homo sapiens] 45 3e-04
gi|145309311 ubiquitin specific protease 9, X-linked isoform 4 [... 39 0.030
gi|145309309 ubiquitin specific protease 9, X-linked isoform 3 [... 39 0.030
gi|156105689 methylmalonyl Coenzyme A mutase precursor [Homo sap... 35 0.44
gi|224600454 MOCO sulphurase C-terminal domain containing 1 [Hom... 35 0.44
gi|187761317 tet oncogene family member 2 isoform a [Homo sapiens] 32 3.7
gi|5453758 nebulette sarcomeric isoform [Homo sapiens] 31 6.3
gi|8659555 aconitase 1 [Homo sapiens] 30 8.3
gi|145301598 hypothetical protein LOC23514 [Homo sapiens] 30 8.3
>gi|194306629 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]
Length = 960
Score = 1950 bits (5052), Expect = 0.0
Identities = 960/960 (100%), Positives = 960/960 (100%)
Query: 1 MFHSSAMVNSHRKPMFNIHRGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGE 60
MFHSSAMVNSHRKPMFNIHRGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGE
Sbjct: 1 MFHSSAMVNSHRKPMFNIHRGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGE 60
Query: 61 RFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNA 120
RFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNA
Sbjct: 61 RFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNA 120
Query: 121 TLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFY 180
TLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFY
Sbjct: 121 TLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFY 180
Query: 181 KSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVK 240
KSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVK
Sbjct: 181 KSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVK 240
Query: 241 TIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYAL 300
TIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYAL
Sbjct: 241 TIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYAL 300
Query: 301 QASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASD 360
QASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASD
Sbjct: 301 QASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASD 360
Query: 361 KLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNV 420
KLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNV
Sbjct: 361 KLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNV 420
Query: 421 CFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQ 480
CFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQ
Sbjct: 421 CFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQ 480
Query: 481 YLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTT 540
YLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTT
Sbjct: 481 YLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTT 540
Query: 541 WTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVI 600
WTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVI
Sbjct: 541 WTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVI 600
Query: 601 HRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRV 660
HRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRV
Sbjct: 601 HRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRV 660
Query: 661 GLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISE 720
GLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISE
Sbjct: 661 GLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISE 720
Query: 721 NLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMES 780
NLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMES
Sbjct: 721 NLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMES 780
Query: 781 SGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKL 840
SGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKL
Sbjct: 781 SGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKL 840
Query: 841 IELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISG 900
IELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISG
Sbjct: 841 IELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISG 900
Query: 901 TTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT 960
TTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT
Sbjct: 901 TTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT 960
>gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]
Length = 960
Score = 1950 bits (5052), Expect = 0.0
Identities = 960/960 (100%), Positives = 960/960 (100%)
Query: 1 MFHSSAMVNSHRKPMFNIHRGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGE 60
MFHSSAMVNSHRKPMFNIHRGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGE
Sbjct: 1 MFHSSAMVNSHRKPMFNIHRGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGE 60
Query: 61 RFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNA 120
RFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNA
Sbjct: 61 RFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNA 120
Query: 121 TLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFY 180
TLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFY
Sbjct: 121 TLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFY 180
Query: 181 KSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVK 240
KSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVK
Sbjct: 181 KSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVK 240
Query: 241 TIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYAL 300
TIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYAL
Sbjct: 241 TIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYAL 300
Query: 301 QASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASD 360
QASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASD
Sbjct: 301 QASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASD 360
Query: 361 KLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNV 420
KLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNV
Sbjct: 361 KLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNV 420
Query: 421 CFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQ 480
CFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQ
Sbjct: 421 CFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQ 480
Query: 481 YLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTT 540
YLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTT
Sbjct: 481 YLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTT 540
Query: 541 WTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVI 600
WTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVI
Sbjct: 541 WTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVI 600
Query: 601 HRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRV 660
HRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRV
Sbjct: 601 HRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRV 660
Query: 661 GLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISE 720
GLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISE
Sbjct: 661 GLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISE 720
Query: 721 NLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMES 780
NLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMES
Sbjct: 721 NLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMES 780
Query: 781 SGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKL 840
SGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKL
Sbjct: 781 SGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKL 840
Query: 841 IELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISG 900
IELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISG
Sbjct: 841 IELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISG 900
Query: 901 TTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT 960
TTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT
Sbjct: 901 TTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT 960
>gi|94818891 type 1 tumor necrosis factor receptor shedding
aminopeptidase regulator isoform b [Homo sapiens]
Length = 941
Score = 967 bits (2501), Expect = 0.0
Identities = 477/934 (51%), Positives = 646/934 (69%), Gaps = 15/934 (1%)
Query: 25 LTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHP 84
++ +L + S PS TE A P ++G FPW ++RLP VIP+HYDL +H
Sbjct: 13 MSFLLSSLLALLTVSTPSWCQSTE---ASPKRSDGTPFPWNKIRLPEYVIPVHYDLLIHA 69
Query: 85 NLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATLQSEEDSRYMKPGKELKVLSYPA 144
NLT+L F + K+E+ S T IILHS L+I+ ATL+ R + + L+VL +P
Sbjct: 70 NLTTLTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGAGERLSE--EPLQVLEHPR 127
Query: 145 HEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQA 204
EQIALL PE L L Y V + + L + F GFYKSTYRT GE RILA T FEPT A
Sbjct: 128 QEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFEPTAA 187
Query: 205 RMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDHFETTVKMSTYLV 264
RMAFPCFDEP FKA+FSIKIRRE RH+A+SNMP VK++ + GL+EDHF+ TVKMSTYLV
Sbjct: 188 RMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTYLV 247
Query: 265 AYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLD 324
A+I+ DF S+S T SGVKVS+YA PDK NQ YAL A++ LL+FYE YF I YPL K D
Sbjct: 248 AFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQD 307
Query: 325 LIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTME 384
L AIPDF GAMENWGL TYRE++LLFD + SSAS KL +T +AHELAHQWFGNLVTME
Sbjct: 308 LAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTME 367
Query: 385 WWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNVCFEVITKDSLNSSRPISKPAETPT 444
WWND+WL EGFAK+ME ++V+ T+PEL+ DYF CF+ + D+LNSS P+S P E P
Sbjct: 368 WWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFDAMEVDALNSSHPVSTPVENPA 427
Query: 445 QIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCL 504
QI+EMFD+VSY+KGACILNML+++L + F+ GI+QYL+K SY+N KN+DLW S+++ C
Sbjct: 428 QIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASIC- 486
Query: 505 ESDFTSG--GVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQ 562
+D G G C S + +S+ + E +VK MM TWTLQKG PL+ + G ++ ++
Sbjct: 487 PTDGVKGMDGFC-SRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITITVRGRNVHMK 545
Query: 563 QERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVIHRHILKSKTDTLDLPEKTSWVK 622
QE +++G A YLWH+PLT+ TS S+++HR +LK+KTD L LPE+ W+K
Sbjct: 546 QEHYMKG------SDGAPDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLILPEEVEWIK 599
Query: 623 FNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALD 682
FNV NGYYIVHYE GWD L L HT + DR LI++ FQLV G+L+++KALD
Sbjct: 600 FNVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALD 659
Query: 683 MTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDK 742
++ YL+HET + +GL+ L Y +M++R+++++ K +L++ + +ID+Q+W+D+
Sbjct: 660 LSLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDE 719
Query: 743 GSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTT 802
GSV +RMLRS LL LAC N+ PC+Q+A F +W ES+G L++P DV V++VGAQ+T
Sbjct: 720 GSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQST 779
Query: 803 AGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAI 862
GW++L +Y+ S+SS E+++I +AL ++++EKL L++ +G IKTQ +L I
Sbjct: 780 EGWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLI 839
Query: 863 ARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLE 922
R P G LAW F+R+NW L++KF+LGS I ++ GTT FS++ +L+EVK FF SL+
Sbjct: 840 GRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLK 899
Query: 923 AQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWL 956
GS L Q +ETI +NI W++KN +R WL
Sbjct: 900 ENGSQLRCVQQTIETIEENIGWMDKNFDKIRVWL 933
>gi|94818901 type 1 tumor necrosis factor receptor shedding
aminopeptidase regulator isoform a [Homo sapiens]
Length = 948
Score = 967 bits (2501), Expect = 0.0
Identities = 477/934 (51%), Positives = 646/934 (69%), Gaps = 15/934 (1%)
Query: 25 LTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHP 84
++ +L + S PS TE A P ++G FPW ++RLP VIP+HYDL +H
Sbjct: 13 MSFLLSSLLALLTVSTPSWCQSTE---ASPKRSDGTPFPWNKIRLPEYVIPVHYDLLIHA 69
Query: 85 NLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATLQSEEDSRYMKPGKELKVLSYPA 144
NLT+L F + K+E+ S T IILHS L+I+ ATL+ R + + L+VL +P
Sbjct: 70 NLTTLTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGAGERLSE--EPLQVLEHPR 127
Query: 145 HEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQA 204
EQIALL PE L L Y V + + L + F GFYKSTYRT GE RILA T FEPT A
Sbjct: 128 QEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFEPTAA 187
Query: 205 RMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDHFETTVKMSTYLV 264
RMAFPCFDEP FKA+FSIKIRRE RH+A+SNMP VK++ + GL+EDHF+ TVKMSTYLV
Sbjct: 188 RMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTYLV 247
Query: 265 AYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLD 324
A+I+ DF S+S T SGVKVS+YA PDK NQ YAL A++ LL+FYE YF I YPL K D
Sbjct: 248 AFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQD 307
Query: 325 LIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTME 384
L AIPDF GAMENWGL TYRE++LLFD + SSAS KL +T +AHELAHQWFGNLVTME
Sbjct: 308 LAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTME 367
Query: 385 WWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNVCFEVITKDSLNSSRPISKPAETPT 444
WWND+WL EGFAK+ME ++V+ T+PEL+ DYF CF+ + D+LNSS P+S P E P
Sbjct: 368 WWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFDAMEVDALNSSHPVSTPVENPA 427
Query: 445 QIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCL 504
QI+EMFD+VSY+KGACILNML+++L + F+ GI+QYL+K SY+N KN+DLW S+++ C
Sbjct: 428 QIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASIC- 486
Query: 505 ESDFTSG--GVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQ 562
+D G G C S + +S+ + E +VK MM TWTLQKG PL+ + G ++ ++
Sbjct: 487 PTDGVKGMDGFC-SRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITITVRGRNVHMK 545
Query: 563 QERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVIHRHILKSKTDTLDLPEKTSWVK 622
QE +++G A YLWH+PLT+ TS S+++HR +LK+KTD L LPE+ W+K
Sbjct: 546 QEHYMKG------SDGAPDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLILPEEVEWIK 599
Query: 623 FNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALD 682
FNV NGYYIVHYE GWD L L HT + DR LI++ FQLV G+L+++KALD
Sbjct: 600 FNVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALD 659
Query: 683 MTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDK 742
++ YL+HET + +GL+ L Y +M++R+++++ K +L++ + +ID+Q+W+D+
Sbjct: 660 LSLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDE 719
Query: 743 GSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTT 802
GSV +RMLRS LL LAC N+ PC+Q+A F +W ES+G L++P DV V++VGAQ+T
Sbjct: 720 GSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQST 779
Query: 803 AGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAI 862
GW++L +Y+ S+SS E+++I +AL ++++EKL L++ +G IKTQ +L I
Sbjct: 780 EGWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLI 839
Query: 863 ARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLE 922
R P G LAW F+R+NW L++KF+LGS I ++ GTT FS++ +L+EVK FF SL+
Sbjct: 840 GRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLK 899
Query: 923 AQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWL 956
GS L Q +ETI +NI W++KN +R WL
Sbjct: 900 ENGSQLRCVQQTIETIEENIGWMDKNFDKIRVWL 933
>gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo sapiens]
Length = 1025
Score = 767 bits (1980), Expect = 0.0
Identities = 401/906 (44%), Positives = 561/906 (61%), Gaps = 36/906 (3%)
Query: 54 PVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSK 113
P ATNG+ FPW ++RLP+ V+PL Y+L +HPNLTS+ F S I V T IILHS
Sbjct: 153 PFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHST 212
Query: 114 DLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLG 173
I+ T S S+ K+ ++L Y H QIA++ PE L Y + +++ A +
Sbjct: 213 GHNISRVTFMSAVSSQE----KQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANIS 268
Query: 174 DGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIAL 233
+ GFY +Y E + A T FEP AR AFPCFDEP FKA F IKI R+ ++ AL
Sbjct: 269 SSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTAL 328
Query: 234 SNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKR 293
SNMPK ++ L+ GL++D F +VKMSTYLVA+IV + +LS + G VSIYA P+K
Sbjct: 329 SNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVN-GTLVSIYAVPEKI 387
Query: 294 NQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDP 353
Q HYAL+ ++KLL+F++ YF+I YPL KLDL+AIPDF GAMENWGL+T+RE +LL+D
Sbjct: 388 GQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDS 447
Query: 354 KTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQF 413
TSS +D+ VT++IAHELAHQWFGNLVTM+WWND+WL EGFA +ME ++ + EL
Sbjct: 448 NTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSS 507
Query: 414 DDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEK 473
+ FL+ F+ + KDSLNSS PIS ++ QI+EMFD +SY KG+ +L MLK +L E+
Sbjct: 508 YEDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDV 567
Query: 474 FQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAE 533
FQ ++ YL SY + ++DDLW S + ++T+ L +
Sbjct: 568 FQHAVVLYLHNHSYASIQSDDLWDSFN------------------EVTNQTL-------D 602
Query: 534 VKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYS 593
VK MM TWTLQKG PL+ V++ G L +QQERF + PE + YLWHIPL+Y
Sbjct: 603 VKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNM---KPEIQPSDTSYLWHIPLSYV 659
Query: 594 TSSSNVIHRH---ILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQN 650
T N +L K+ ++L E+ WVK N++ NGYYIVHY W+ LI QL N
Sbjct: 660 TEGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKIN 719
Query: 651 HTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMM 710
+L KDR LI+++F+L G G++ L +A D+ YL +E + + E L + Y+++
Sbjct: 720 PYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLL 779
Query: 711 DRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKA 770
++ D++ L + + + I +Q+W+D+G+ R LRSALL+ AC N C A
Sbjct: 780 EKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTA 839
Query: 771 AELFSQWMESSGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALST 830
+LF WM S+G ++PTDV+ V+ VGA+T GW++LL +Y S AE+NKIL AL++
Sbjct: 840 MKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALAS 899
Query: 831 SKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLG 890
S+ KL L++ + G +TQ L+ ++ + R G LAWDFV+ENW L++KF LG
Sbjct: 900 SEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLG 959
Query: 891 SYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLP 950
SY I+ I++G+T FS+K L EV+ FFE+ L Q LE I NI+W+EKNL
Sbjct: 960 SYTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLK 1019
Query: 951 TLRTWL 956
+L WL
Sbjct: 1020 SLTWWL 1025
>gi|61742775 leucyl/cystinyl aminopeptidase isoform 2 [Homo sapiens]
Length = 1011
Score = 767 bits (1980), Expect = 0.0
Identities = 401/906 (44%), Positives = 561/906 (61%), Gaps = 36/906 (3%)
Query: 54 PVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSK 113
P ATNG+ FPW ++RLP+ V+PL Y+L +HPNLTS+ F S I V T IILHS
Sbjct: 139 PFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHST 198
Query: 114 DLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLG 173
I+ T S S+ K+ ++L Y H QIA++ PE L Y + +++ A +
Sbjct: 199 GHNISRVTFMSAVSSQE----KQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANIS 254
Query: 174 DGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIAL 233
+ GFY +Y E + A T FEP AR AFPCFDEP FKA F IKI R+ ++ AL
Sbjct: 255 SSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTAL 314
Query: 234 SNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKR 293
SNMPK ++ L+ GL++D F +VKMSTYLVA+IV + +LS + G VSIYA P+K
Sbjct: 315 SNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVN-GTLVSIYAVPEKI 373
Query: 294 NQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDP 353
Q HYAL+ ++KLL+F++ YF+I YPL KLDL+AIPDF GAMENWGL+T+RE +LL+D
Sbjct: 374 GQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDS 433
Query: 354 KTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQF 413
TSS +D+ VT++IAHELAHQWFGNLVTM+WWND+WL EGFA +ME ++ + EL
Sbjct: 434 NTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSS 493
Query: 414 DDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEK 473
+ FL+ F+ + KDSLNSS PIS ++ QI+EMFD +SY KG+ +L MLK +L E+
Sbjct: 494 YEDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDV 553
Query: 474 FQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAE 533
FQ ++ YL SY + ++DDLW S + ++T+ L +
Sbjct: 554 FQHAVVLYLHNHSYASIQSDDLWDSFN------------------EVTNQTL-------D 588
Query: 534 VKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYS 593
VK MM TWTLQKG PL+ V++ G L +QQERF + PE + YLWHIPL+Y
Sbjct: 589 VKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNM---KPEIQPSDTSYLWHIPLSYV 645
Query: 594 TSSSNVIHRH---ILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQN 650
T N +L K+ ++L E+ WVK N++ NGYYIVHY W+ LI QL N
Sbjct: 646 TEGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKIN 705
Query: 651 HTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMM 710
+L KDR LI+++F+L G G++ L +A D+ YL +E + + E L + Y+++
Sbjct: 706 PYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLL 765
Query: 711 DRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKA 770
++ D++ L + + + I +Q+W+D+G+ R LRSALL+ AC N C A
Sbjct: 766 EKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTA 825
Query: 771 AELFSQWMESSGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALST 830
+LF WM S+G ++PTDV+ V+ VGA+T GW++LL +Y S AE+NKIL AL++
Sbjct: 826 MKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALAS 885
Query: 831 SKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLG 890
S+ KL L++ + G +TQ L+ ++ + R G LAWDFV+ENW L++KF LG
Sbjct: 886 SEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLG 945
Query: 891 SYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLP 950
SY I+ I++G+T FS+K L EV+ FFE+ L Q LE I NI+W+EKNL
Sbjct: 946 SYTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLK 1005
Query: 951 TLRTWL 956
+L WL
Sbjct: 1006 SLTWWL 1011
>gi|132814467 glutamyl aminopeptidase [Homo sapiens]
Length = 957
Score = 538 bits (1387), Expect = e-153
Identities = 311/913 (34%), Positives = 490/913 (53%), Gaps = 56/913 (6%)
Query: 56 ATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDL 115
A+ E W+ RLP V P+HYDL V P L + + I + +S T+++ LH ++
Sbjct: 80 ASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRET 139
Query: 116 EITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLK---YYVAMDFQAKL 172
IT ++ + Y E + + E+LTP Y + M+F L
Sbjct: 140 RITRLPELKRPSGDQVQVRR---CFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWL 196
Query: 173 GDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIA 232
GFY++TY T G+ + + TD EPT AR +FPCFDEP KA ++I I + A
Sbjct: 197 NGSLVGFYRTTY-TENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGA 255
Query: 233 LSNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDK 292
LSNMP K ++ FE +V MSTYLV + V F S+ ++SG ++IY P++
Sbjct: 256 LSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQ 315
Query: 293 RNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFD 352
++ YA + + D++E+YF + Y L KLD IAIPDF GAMENWGLITYRET+LL+D
Sbjct: 316 KHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYD 375
Query: 353 PKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQ 412
PK S++S++ V V+AHEL HQWFGN+VTM+WW D+WL EGFA + E + VN + Q
Sbjct: 376 PKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQ 435
Query: 413 F-DDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGE 471
D L V DSL SS PI TP +I +FD +SY+KG+ IL ML+D++
Sbjct: 436 MRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKP 495
Query: 472 EKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGEN 531
E FQKG YL+K+ ++NAK D W++L +
Sbjct: 496 ENFQKGCQMYLEKYQFKNAKTSDFWAALEEA---------------------------SR 528
Query: 532 AEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLT 591
VKE+M TWT Q G P+L V +G + Q+RFL + +P Y W+IP+
Sbjct: 529 LPVKEVMDTWTRQMGYPVLNV--NGVK-NITQKRFLLDP-RANPSQPPSDLGYTWNIPVK 584
Query: 592 Y---STSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLN 648
+ + +SS + +R + T P +++K N D G+Y V+YE WD + T L+
Sbjct: 585 WTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALS 644
Query: 649 QNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSS---PALLEGLSYLES 705
NH DR LI D F L A L AL++T YL+ E + ++ ++Y+ S
Sbjct: 645 LNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIIS 704
Query: 706 FYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAP 765
+ + ++ ++ Y KP+ D W+D G ++LRS++L AC +
Sbjct: 705 MF-----EDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDRE 759
Query: 766 CIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTTA---GWNYLLEQYELSMSSAEQN 822
+ A+ LF QW+ +G +++P ++ +VY G Q + WNY LEQY+ + + E+
Sbjct: 760 ALNNASSLFEQWL--NGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKE 817
Query: 823 KILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTH 882
K+LY L++ K+ L + ++L + +IKTQ++ ++ I+ G+ +AW++++ NW +
Sbjct: 818 KLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDY 877
Query: 883 LLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNI 942
L+ ++ L + ++ I++ F+++ +L +++ FF G+ + VLET+ NI
Sbjct: 878 LVNRYTLNNRNLGRIVT-IAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNI 936
Query: 943 KWLEKNLPTLRTW 955
+WL+++ T+R W
Sbjct: 937 EWLKQHRNTIREW 949
>gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo
sapiens]
Length = 1024
Score = 495 bits (1274), Expect = e-140
Identities = 299/914 (32%), Positives = 467/914 (51%), Gaps = 50/914 (5%)
Query: 63 PWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATL 122
PW +LRL + PLHY+L + + + F +E+ NAT++++LH+ + + L
Sbjct: 135 PWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQL 194
Query: 123 QSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKS 182
+ R YP + + +++ L Y + + + A + + GF++S
Sbjct: 195 AED---RAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRS 251
Query: 183 TYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTI 242
+Y L GE R L VT F PT AR AFPCFDEP++KA F I I+ ++ +++LSNMP ++
Sbjct: 252 SY-VLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSV 310
Query: 243 ELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPD--KRNQTHYAL 300
E G + DHF T MSTY +A+ +C+F T SGV V +YA PD +R YAL
Sbjct: 311 FEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYAL 370
Query: 301 QASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASD 360
+ +L++FYE YF + Y L KLDL+A+P AMENWGL + E +L DP SS S
Sbjct: 371 HITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISY 430
Query: 361 KLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYP--ELQFDDYFL 418
L VT VI HE+ HQWFG+LVT WW D+WLKEGFA Y E + + YP ++ +
Sbjct: 431 LLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLT 490
Query: 419 NVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGI 478
+V EV+ D L SS P+S+ T I +FD ++Y KGA ++ ML +F+G FQ+G+
Sbjct: 491 DVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGL 550
Query: 479 IQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMM 538
YL Y NA +DLW++LS + + G+ ++E+M
Sbjct: 551 QDYLTIHKYGNAARNDLWNTLSEALKRN----------------------GKYVNIQEVM 588
Query: 539 TTWTLQKGIPLLVVKQDGCS---LRLQQERFLQGVFQEDPEWRALQERYLWHIPLTY--- 592
WTLQ G P++ + + + + + Q+ F+ + + + YLW IPLT
Sbjct: 589 DQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVG 648
Query: 593 --STSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQN 650
S SS I KS+ + +K SW+ N++ GY+ V+Y+ W LI QL +N
Sbjct: 649 NRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRN 708
Query: 651 HTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSS---PALLEGLSYLESFY 707
H +L +R GLI D F L AG L + L++ YL E A L L+
Sbjct: 709 HEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLL 768
Query: 708 HMMDRRNISDISENLKRYLLQYFKPVIDRQSWSD---KGSVWDRMLRSALLKLACDLNHA 764
M+ NI + LK+ Y K + +++ + S LR ++ LAC +
Sbjct: 769 DRMENYNIFN-EYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNK 827
Query: 765 PCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTTAG--WNYLLEQYELSMSSAEQN 822
C Q+A+ L S W+ SS + IP +V IVY G W ++ ++ + + +E+
Sbjct: 828 HCHQQASTLISDWI-SSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKK 886
Query: 823 KILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTH 882
+L AL+ S + L +L+ L + +V+ Q+ ++ +AR P G+ LAW F R+ W
Sbjct: 887 ILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKI 946
Query: 883 LLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNI 942
L ++ + +ISG T +++ +L+E+K F ++ + G F +ET+ N+
Sbjct: 947 LNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNYD--GVAAASFSRAVETVEANV 1004
Query: 943 KWLEKNLPTLRTWL 956
+W L WL
Sbjct: 1005 RWKMLYQDELFQWL 1018
>gi|157266300 membrane alanine aminopeptidase precursor [Homo
sapiens]
Length = 967
Score = 459 bits (1182), Expect = e-129
Identities = 308/930 (33%), Positives = 459/930 (49%), Gaps = 67/930 (7%)
Query: 64 WQELRLPSVVIPLHYDLFVHPNLTSLD-----FVASEKIEVLVSNATQFIILHSKDLEIT 118
W RLP+ + P Y + + P LT D F S + AT II+HSK L T
Sbjct: 71 WNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYT 130
Query: 119 -----NATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLG 173
L+ S+ P + L P E + + + L +Y + +F+ +L
Sbjct: 131 LSQGHRVVLRGVGGSQ--PPDIDKTELVEPT-EYLVVHLKGSLVKDSQYEMDSEFEGELA 187
Query: 174 DGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIAL 233
D GFY+S Y G +++A T + AR +FPCFDEP KA F+I + AL
Sbjct: 188 DDLAGFYRSEYME-GNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTAL 246
Query: 234 SNM-PKVKTIEL--EGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASP 290
SNM PK + L + F TT KMSTYL+A+IV +F + S+GV + I+A P
Sbjct: 247 SNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARP 306
Query: 291 DKRNQTH--YALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETS 348
H YAL + +L+F+ ++D YPL K D I +PDF GAMENWGL+TYRE S
Sbjct: 307 SAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENS 366
Query: 349 LLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATY 408
LLFDP +SS+S+K V VIAHELAHQWFGNLVT+EWWND+WL EGFA Y+E + +
Sbjct: 367 LLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAE 426
Query: 409 PELQFDDYF-LNVCFEVITKDSLNSSRPISKPAE---TPTQIQEMFDEVSYNKGACILNM 464
P D LN + V+ D+L SS P+S PA TP QI E+FD +SY+KGA +L M
Sbjct: 427 PTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRM 486
Query: 465 LKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNM 524
L FL E+ F++G+ YL F+Y+N +LW L + +N
Sbjct: 487 LSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEA------------------VNNR 528
Query: 525 LAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPE---WRALQ 581
L V+++M WTLQ G P++ V D + L QE FL DP+ R +
Sbjct: 529 SIQLPTT--VRDIMNRWTLQMGFPVITV--DTSTGTLSQEHFLL-----DPDSNVTRPSE 579
Query: 582 ERYLWHIPLTYSTSSSNVIHRHILKSKTDT-LDLPEKTSWVKFNVDSNGYYIVHYEGHGW 640
Y+W +P+T ++ + L WV N++ GYY V+Y+ W
Sbjct: 580 FNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENW 639
Query: 641 DQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGL 700
++ TQL ++H+ + +R +I+D F L A ++ + AL+ T +L E L
Sbjct: 640 RKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAAL 699
Query: 701 SYLESFYHMMDRRNISDISENLKRYLLQYFKPVI-----DRQSWSD-KGSVWDRMLRSAL 754
S L F M DR S++ +K YL + P+ + +W + ++ D+
Sbjct: 700 SSLSYFKLMFDR---SEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNA 756
Query: 755 LKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVY--SVGAQTTAGWNYLLEQY 812
+ AC C + + LF QWME+ I ++ VY ++ W++ EQ+
Sbjct: 757 ISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQF 816
Query: 813 ELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLA 872
+ E +K+ AL+ SK L + + + +I+ Q+ + + +I GQ L
Sbjct: 817 RNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLV 876
Query: 873 WDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQ--GSHLDI 930
WDFV+ NW L + GS+ +I T FS++ +LQ+++ F + E GS
Sbjct: 877 WDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRA 936
Query: 931 FQTVLETITKNIKWLEKNLPTLRTWLMVNT 960
+ LE NIKW+++N + W N+
Sbjct: 937 LEQALEKTKANIKWVKENKEVVLQWFTENS 966
>gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens]
Length = 919
Score = 450 bits (1158), Expect = e-126
Identities = 305/929 (32%), Positives = 470/929 (50%), Gaps = 86/929 (9%)
Query: 55 VATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVL--VSNATQFIILHS 112
+A E+ P++ RLP+ V P++Y L + P+L LDF K+E V AT I+++
Sbjct: 42 LAAMPEKRPFE--RLPADVSPINYSLCLKPDL--LDFTFEGKLEAAAQVRQATNQIVMNC 97
Query: 113 KDLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKL---TPHLKYYVAMDFQ 169
D++I A+ E D G + E++ L P L T LK +DF
Sbjct: 98 ADIDIITASYAPEGDEEIHATGFNYQ----NEDEKVTLSFPSTLQTGTGTLK----IDFV 149
Query: 170 AKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESR 229
+L D +GFY+S Y T GE R AVT FE T AR AFPC+DEP KA F I +
Sbjct: 150 GELNDKMKGFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKD 209
Query: 230 HIALSNMPKV--KTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIY 287
+ALSNM + K + L+E F T MSTYLVA++V ++ + + GV V +Y
Sbjct: 210 RVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVY 269
Query: 288 ASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRET 347
K Q +AL+ + K L FY+ YF++ YPL K+DLIAI DFA GAMENWGL+TYRET
Sbjct: 270 TPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRET 329
Query: 348 SLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNAT 407
+LL DPK S +S + WV V+ HELAHQWFGNLVTMEWW +WL EGFA ++E + V+
Sbjct: 330 ALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHC 389
Query: 408 YPELQFDDYFLNVCFEVITK-DSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLK 466
+PE F++ + + D+L++S PI P+++ E+FD +SY+KGA ++ ML
Sbjct: 390 FPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLH 449
Query: 467 DFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLA 526
D++G++ F+KG+ YL KF +NA +DLW SL N+
Sbjct: 450 DYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENA------------------------ 485
Query: 527 FLGENAEVKEMMTTWTLQKGIPLLVVK----QDGCSLRLQQERFLQG---VFQEDPEWRA 579
+ +M TWT Q G PL+ V+ +D LRL Q++F G V ++ P+W
Sbjct: 486 ---SGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWM- 541
Query: 580 LQERYLWHIPLTYSTSSS-NVIHRHILKSKTD---TLDLPEKTSWVKFNVDSNGYYIVHY 635
+P+T STS N IL K + L + WVK N+ + G+Y Y
Sbjct: 542 --------VPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQY 593
Query: 636 EGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPA 695
+ L+ + L P DR+GL +D+F L AG ++ + L + +E +
Sbjct: 594 SSAMLESLLPGIRD--LSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTV 651
Query: 696 LLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSV--WDRMLRSA 753
+ L ++ +D E ++ ++ F P+ +R W K D +LR
Sbjct: 652 WSDLSCNLGILSTLLSH---TDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGL 708
Query: 754 LLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVYSV----GAQTTAGWNYLL 809
+L H +++A F +E GK + D+ VY G TT + +L
Sbjct: 709 VLGKLGKAGHKATLEEARRRFKDHVE--GKQILSADLRSPVYLTVLKHGDGTTL--DIML 764
Query: 810 EQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPK-G 868
+ ++ + E+N+I L + + + K++ + +V + Q+ +++ +A K G
Sbjct: 765 KLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFALSEEV-RPQDTVSVIGGVAGGSKHG 823
Query: 869 QQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHL 928
++ AW F+++NW L ++ G + I +I + F+ EVK FFES A +
Sbjct: 824 RKAAWKFIKDNWEELYNRYQ-GGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAER 882
Query: 929 DIFQTVLETITKNIKWLEKNLPTLRTWLM 957
I Q E I N WL+++ ++ +L+
Sbjct: 883 TI-QQCCENILLNAAWLKRDAESIHQYLL 910
>gi|194239713 laeverin [Homo sapiens]
Length = 990
Score = 375 bits (963), Expect = e-103
Identities = 277/935 (29%), Positives = 442/935 (47%), Gaps = 73/935 (7%)
Query: 63 PWQELRLPSVVIPLHYDLFVHPNLT-------SLDFVASEKIEVLVSNATQFIILHSKDL 115
PW +LRLP ++PLHYDL + P L SL F I V + AT ++LHS
Sbjct: 92 PWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQ 151
Query: 116 EITNATLQSEEDSRYMKPGK-ELKVLSYPAH--------EQIALLVPEKLTPHLKYYVAM 166
+ A ++ + PG V P E + L + E L P Y + +
Sbjct: 152 DCERAEVRGP-----LSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGSSYELQL 206
Query: 167 DFQAKLGDGF-EGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIR 225
F + + EG + + Y T GE R L + EPT AR FPCFDEP KA F+I +
Sbjct: 207 SFSGLVKEDLREGLFLNVY-TDQGERRALLASQLEPTFARYVFPCFDEPALKATFNITMI 265
Query: 226 RESRHIALSNMPKVKTIELE----GGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSG 281
++ALSNMPK+ E E F TT M TYLVA+++CD+ ++ T G
Sbjct: 266 HHPSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNR-TERG 324
Query: 282 VKVSIYASPDK--RNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENW 339
++ I+A D +AL + + F E F+I Y L K D+IA+P F AMENW
Sbjct: 325 KEIRIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENW 384
Query: 340 GLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYM 399
GL+ + E+ LL +PK K ++ V++HE+ HQWFGNLVTM WWN+IWL EGFA Y
Sbjct: 385 GLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYF 444
Query: 400 ELIAVNATYPELQFDD-YFLNVCFEVITKDSLNSSRPISKPAET--PTQIQEMFDEVSYN 456
E +N P+L ++ +F N+ ++ +D +R ++ E ++IQE+FD +Y+
Sbjct: 445 EFEVINYFNPKLPRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYS 504
Query: 457 KGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHS 516
KGA + ML FL E F + YLK FSY NA+ DDLW H
Sbjct: 505 KGASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWR-----------------HF 547
Query: 517 DPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPE 576
+ L A +K +M +WT Q G P++ + + Q+ +L+ +
Sbjct: 548 QMAIDDQSTVIL--PATIKNIMDSWTHQSGFPVITLNV-STGVMKQEPFYLENIKNR--- 601
Query: 577 WRALQERYLWHIPLTYSTSSSNVIHRHILKSKTDTLDLPEKTS---WVKFNVDSNGYYIV 633
L W +P+ + + + + +S ++ S WV N++ GYY V
Sbjct: 602 -TLLTSNDTWIVPILWIKNGTTQPLVWLDQSSKVFPEMQVSDSDHDWVILNLNMTGYYRV 660
Query: 634 HYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSS 693
+Y+ GW +L QL ++ + R+ LI D F L + ++ AL++T YL E
Sbjct: 661 NYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEI 720
Query: 694 PALLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVW----DRM 749
L L + ++ NI DI LKRYLL+ + + S + +V D +
Sbjct: 721 IVWHTVLVNLVT-RDLVSEVNIYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQDDYL 779
Query: 750 LRSALLKL---ACDLNHAPCIQKAAELFSQWME-SSGKLNIPTDVLKIVYSVGAQTTAGW 805
+L KL AC L C+Q + ELF++W++ ++ P + + Y + + W
Sbjct: 780 ALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDKEW 839
Query: 806 NYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARR 865
+ LL Y + + E+ ++ YA+S SK L + +E + T N ++ +A
Sbjct: 840 DILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPF-TSNETNIIEVVASS 898
Query: 866 PKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQG 925
G+ +A DF+ NW + K++ G+ + +I ++ ++ E++ FF ++ +
Sbjct: 899 EVGRYVAKDFLVNNWQAVSKRY--GTQSLINLIYTIGRTVTTDLQIVELQQFFSNMLEEH 956
Query: 926 SHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT 960
+ + + +N+K +K + WL NT
Sbjct: 957 QRIRVHANLQTIKNENLK-NKKLSARIAAWLRRNT 990
>gi|40316915 arginyl aminopeptidase [Homo sapiens]
Length = 650
Score = 87.8 bits (216), Expect = 4e-17
Identities = 99/393 (25%), Positives = 165/393 (41%), Gaps = 37/393 (9%)
Query: 115 LEITNATLQSEEDSRYMKPGKELKVLSYP-AHEQIALLV--PEKLTPHLKYYVAMDFQAK 171
LE+T A L+ E P + + + P +H AL V P+ + V + + +
Sbjct: 86 LEVTAAALRRERPGSEEPPAEPVSFYTQPFSHYGQALCVSFPQPCRAAERLQVLLTY--R 143
Query: 172 LGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHI 231
+G+G + + +T G+ + T + R FPCFD P K +S I
Sbjct: 144 VGEGPGVCWLAPEQT-AGKKKPFVYTQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFT 202
Query: 232 ALSNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPD 291
A+ + T E G + F+ + +YL+A + D S G + ++A P
Sbjct: 203 AVMS---ASTWEKRGPN-KFFFQMCQPIPSYLIALAIGDLVS----AEVGPRSRVWAEPC 254
Query: 292 KRNQTHYALQASLK-LLDFYEKYFDIYYPLSKLDLIAIPDFAP-GAMENWGLITYRETSL 349
+ ++ L EK F Y + DL+ +P P G MEN +T+ L
Sbjct: 255 LIDAAKEEYNGVIEEFLATGEKLFGPYV-WGRYDLLFMPPSFPFGGMEN-PCLTFVTPCL 312
Query: 350 LFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYME------LIA 403
L ++ + VI HE++H WFGNLVT W + WL EGF Y + L
Sbjct: 313 LAGDRS--------LADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFG 364
Query: 404 VNATYPELQFDDYFLNVCFEVITKDS-LNSSRPISKPAETPTQIQEMFDEVSYNKGACIL 462
T E L ++ +++ LN R +P P + ++E Y KG C +
Sbjct: 365 AAYTCLEAATGRALLRQHMDITGEENPLNKLRVKIEPGVDP---DDTYNETPYEKGFCFV 421
Query: 463 NMLKDFLG-EEKFQKGIIQYLKKFSYRNAKNDD 494
+ L +G +++F + Y+ +F +R+ DD
Sbjct: 422 SYLAHLVGDQDQFDSFLKAYVHEFKFRSILADD 454
>gi|4505029 leukotriene A4 hydrolase [Homo sapiens]
Length = 611
Score = 81.6 bits (200), Expect = 3e-15
Identities = 91/394 (23%), Positives = 158/394 (40%), Gaps = 29/394 (7%)
Query: 108 IILHSKDLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMD 167
++L +KDL I + +E + + K + + +P L+ + + + +
Sbjct: 53 LVLDTKDLTIEKVVINGQEVKYALGERQSYK------GSPMEISLPIALSKNQEIVIEIS 106
Query: 168 FQAKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRE 227
F+ T G+ + + R PC D P K ++ ++
Sbjct: 107 FETSPKSS--ALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVP 164
Query: 228 SRHIAL-SNMPKVKTIELEGGLLEDH-FETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVS 285
+AL S + +T + E + + F V + YL+A +V S G +
Sbjct: 165 KELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALES----RQIGPRTL 220
Query: 286 IYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAP-GAMENWGLITY 344
+++ ++ ++ Y + +L E Y + DL+ +P P G MEN
Sbjct: 221 VWSEKEQVEKSAYEFSETESMLKIAEDLGGPYV-WGQYDLLVLPPSFPYGGMEN------ 273
Query: 345 RETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAV 404
L F T A DK ++ VIAHE++H W GNLVT + W+ WL EG Y+E
Sbjct: 274 --PCLTFVTPTLLAGDKS-LSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHIC 330
Query: 405 NATYPELQFDDYFLNVCFEVITK-DSLNSSRPISKPAETPTQIQE--MFDEVSYNKGACI 461
+ E L E+ + + P +K T I + V Y KG +
Sbjct: 331 GRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFAL 390
Query: 462 LNMLKDFLGEEKFQKGIIQ-YLKKFSYRNAKNDD 494
L L+ LG + G ++ Y++KFSY++ DD
Sbjct: 391 LFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDD 424
>gi|54020718 arginyl aminopeptidase (aminopeptidase B)-like 1 [Homo
sapiens]
Length = 494
Score = 72.4 bits (176), Expect = 2e-12
Identities = 69/257 (26%), Positives = 113/257 (43%), Gaps = 27/257 (10%)
Query: 252 HFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYALQASLKL-LDFY 310
HF + YLVA + D G + ++A P L +++ L
Sbjct: 16 HFHMEHPVPAYLVALVAGDLKP----ADIGPRSRVWAEPCLLPTATSKLSGAVEQWLSAA 71
Query: 311 EKYFDIYYPLSKLDLIAIPDFAP-GAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIA 369
E+ + Y + D++ +P P AMEN +T+ +S+L SD+ V VI
Sbjct: 72 ERLYGPYM-WGRYDIVFLPPSFPIVAMEN-PCLTFIISSIL-------ESDEFLVIDVI- 121
Query: 370 HELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYP------ELQFDDYFLNVCFE 423
HE+AH WFGN VT W ++WL EG A Y + TY E F L+ +
Sbjct: 122 HEVAHSWFGNAVTNATWEEMWLSEGLATYAQRRITTETYGAAFTCLETAFRLDALHRQMK 181
Query: 424 VITKDSLNSSRPIS-KPAETPTQIQEMFDEVSYNKGACILNMLKDFLGE-EKFQKGIIQY 481
++ +DS S + +P P+ + +F +Y KG C + L G+ ++F + Y
Sbjct: 182 LLGEDSPVSKLQVKLEPGVNPSHLMNLF---TYEKGYCFVYYLSQLCGDPQRFDDFLRAY 238
Query: 482 LKKFSYRNAKNDDLWSS 498
++K+ + + DL S
Sbjct: 239 VEKYKFTSVVAQDLLDS 255
>gi|4507347 TBP-associated factor 2 [Homo sapiens]
Length = 1199
Score = 45.1 bits (105), Expect = 3e-04
Identities = 49/216 (22%), Positives = 91/216 (42%), Gaps = 28/216 (12%)
Query: 205 RMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDHFETTVKMSTYLV 264
R FPC D + ++ ++ +A+SN G L+E + ++ T+
Sbjct: 187 RFWFPCVDSYSELCTWKLEFTVDAAMVAVSN----------GDLVETVYTHDMRKKTF-- 234
Query: 265 AYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYALQASLKLL-----------DFYEKY 313
Y++ + S + + I P TH+ L L LL +FYE+
Sbjct: 235 HYMLTIPTAASNISLAIGPFEILVDPYMHEVTHFCLPQLLPLLKHTTSYLHEVFEFYEEI 294
Query: 314 FDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTR-VIAHEL 372
YP S + I D A + + ++ T+LL ++ D+ +TR +A L
Sbjct: 295 LTCRYPYSCFKTVFI-DEAYVEVAAYASMSIFSTNLLH---SAMIIDETPLTRRCLAQSL 350
Query: 373 AHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATY 408
A Q+FG ++ W+D W+ +G + Y+ + + T+
Sbjct: 351 AQQFFGCFISRMSWSDEWVLKGISGYIYGLWMKKTF 386
>gi|145309311 ubiquitin specific protease 9, X-linked isoform 4
[Homo sapiens]
Length = 2554
Score = 38.5 bits (88), Expect = 0.030
Identities = 44/151 (29%), Positives = 65/151 (43%), Gaps = 26/151 (17%)
Query: 781 SGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAE---QNKIL-YALSTSKHQ-- 834
+GK+N +V K++ SV T N E++ + AE QN IL L S HQ
Sbjct: 349 NGKMNALNEVNKVISSVSYYTHRHGNPEEEEWLTAERMAEWIQQNNILSIVLRDSLHQPQ 408
Query: 835 --EKLLKLIELGMEGKVIKTQNLAALLHAIARRPKG---------QQLAWDFVRENWTHL 883
EKL K++ ++ K + Q+L + A A + + +LAWDF E HL
Sbjct: 409 YVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPEQLDHL 468
Query: 884 LKKFDLGSYDIRMIISGTTAHFSSKDKLQEV 914
F S T A ++KL E+
Sbjct: 469 FDCFK---------ASWTNASKKQREKLLEL 490
>gi|145309309 ubiquitin specific protease 9, X-linked isoform 3
[Homo sapiens]
Length = 2570
Score = 38.5 bits (88), Expect = 0.030
Identities = 44/151 (29%), Positives = 65/151 (43%), Gaps = 26/151 (17%)
Query: 781 SGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAE---QNKIL-YALSTSKHQ-- 834
+GK+N +V K++ SV T N E++ + AE QN IL L S HQ
Sbjct: 349 NGKMNALNEVNKVISSVSYYTHRHGNPEEEEWLTAERMAEWIQQNNILSIVLRDSLHQPQ 408
Query: 835 --EKLLKLIELGMEGKVIKTQNLAALLHAIARRPKG---------QQLAWDFVRENWTHL 883
EKL K++ ++ K + Q+L + A A + + +LAWDF E HL
Sbjct: 409 YVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPEQLDHL 468
Query: 884 LKKFDLGSYDIRMIISGTTAHFSSKDKLQEV 914
F S T A ++KL E+
Sbjct: 469 FDCFK---------ASWTNASKKQREKLLEL 490
>gi|156105689 methylmalonyl Coenzyme A mutase precursor [Homo
sapiens]
Length = 750
Score = 34.7 bits (78), Expect = 0.44
Identities = 26/72 (36%), Positives = 31/72 (43%), Gaps = 17/72 (23%)
Query: 560 RLQQERFLQGVFQEDPEWRALQERYL---------WHIPLTYSTSSSNVIHRHILKSKTD 610
RL Q+R L PEW AL ++ L WH P S L SK D
Sbjct: 26 RLIQQRLLHQQQPLHPEWAALAKKQLKGKNPEDLIWHTPEGISIKP--------LYSKRD 77
Query: 611 TLDLPEKTSWVK 622
T+DLPE+ VK
Sbjct: 78 TMDLPEELPGVK 89
>gi|224600454 MOCO sulphurase C-terminal domain containing 1 [Homo
sapiens]
Length = 337
Score = 34.7 bits (78), Expect = 0.44
Identities = 30/114 (26%), Positives = 53/114 (46%), Gaps = 6/114 (5%)
Query: 550 LVVKQDGCSLRLQQE-RFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVIHR-HILKS 607
LV+ Q+G + +QE R + D + L Y + L T ++N +H+ +
Sbjct: 95 LVINQEGNMVTARQEPRLVLISLTCDGDTLTLSAAYTKDLLLPIKTPTTNAVHKCRVHGL 154
Query: 608 KTDTLDLPEKTS-WVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRV 660
+ + D E T+ W+ + S Y +VH+E H + +Q L RPKD++
Sbjct: 155 EIEGRDCGEATAQWITSFLKSQPYRLVHFEPH---MRPRRPHQIADLFRPKDQI 205
>gi|187761317 tet oncogene family member 2 isoform a [Homo sapiens]
Length = 2002
Score = 31.6 bits (70), Expect = 3.7
Identities = 21/77 (27%), Positives = 39/77 (50%), Gaps = 8/77 (10%)
Query: 440 AETPTQIQEMFDEVSYNKGACI---LNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLW 496
+ T + +M +++++ AC+ L+ L D G+EK ++Q + + ND++W
Sbjct: 1791 SHTANGLSKMLPALNHDRTACVQGGLHKLSDANGQEKQPLALVQGVASGA---EDNDEVW 1847
Query: 497 SSLSNSCLESDFTSGGV 513
S S L+ D GGV
Sbjct: 1848 SDSEQSFLDPDI--GGV 1862
>gi|5453758 nebulette sarcomeric isoform [Homo sapiens]
Length = 1014
Score = 30.8 bits (68), Expect = 6.3
Identities = 21/102 (20%), Positives = 43/102 (42%), Gaps = 9/102 (8%)
Query: 393 EGFAKYMELIAVNATYPELQFDDYFLNVCFEVITKDSLNSSRPISKP-AETPTQIQEMFD 451
+GF+ Y + ++ + + N+ + +D+ S + +P + TQI ++
Sbjct: 134 KGFSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQDTHTYSAELDRPDIKMATQISKIIS 193
Query: 452 EVSYNKGACILNMLKDFLGEEKFQKGI--------IQYLKKF 485
Y KG I+N +G F+ + I+Y +KF
Sbjct: 194 NAEYKKGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKF 235
>gi|8659555 aconitase 1 [Homo sapiens]
Length = 889
Score = 30.4 bits (67), Expect = 8.3
Identities = 19/61 (31%), Positives = 29/61 (47%), Gaps = 6/61 (9%)
Query: 133 PGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMD----FQAKLGDGFEGFYKSTYRTLG 188
PG+ L E+ +++PE L P +K V +D FQA + F+ + TY G
Sbjct: 820 PGENADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVM--RFDTDVELTYFLNG 877
Query: 189 G 189
G
Sbjct: 878 G 878
>gi|145301598 hypothetical protein LOC23514 [Homo sapiens]
Length = 915
Score = 30.4 bits (67), Expect = 8.3
Identities = 16/48 (33%), Positives = 23/48 (47%)
Query: 50 PGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKI 97
P A P+ T G P +E++ L Y L HPNL +D + + I
Sbjct: 575 PPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHPNLGQIDIIDEDPI 622
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,122,965
Number of Sequences: 37866
Number of extensions: 1522272
Number of successful extensions: 3198
Number of sequences better than 10.0: 23
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 3106
Number of HSP's gapped (non-prelim): 30
length of query: 960
length of database: 18,247,518
effective HSP length: 112
effective length of query: 848
effective length of database: 14,006,526
effective search space: 11877534048
effective search space used: 11877534048
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.