Guide to the Human Genome
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Search of human proteins with 116256333

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|116256333 membrane metallo-endopeptidase [Homo sapiens]
         (750 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|116256333 membrane metallo-endopeptidase [Homo sapiens]           1524   0.0  
gi|116256331 membrane metallo-endopeptidase [Homo sapiens]           1524   0.0  
gi|116256327 membrane metallo-endopeptidase [Homo sapiens]           1524   0.0  
gi|116256329 membrane metallo-endopeptidase [Homo sapiens]           1524   0.0  
gi|239049391 membrane metallo-endopeptidase-like 1 [Homo sapiens]     832   0.0  
gi|164519140 endothelin converting enzyme 1 isoform 2 [Homo sapi...   541   e-153
gi|164519138 endothelin converting enzyme 1 isoform 4 [Homo sapi...   541   e-153
gi|164519136 endothelin converting enzyme 1 isoform 3 [Homo sapi...   541   e-153
gi|4503443 endothelin converting enzyme 1 isoform 1 [Homo sapiens]    541   e-153
gi|153945836 endothelin converting enzyme 2 isoform E [Homo sapi...   487   e-137
gi|153945771 endothelin converting enzyme 2 isoform D [Homo sapi...   487   e-137
gi|82617560 endothelin converting enzyme 2 isoform B [Homo sapiens]   487   e-137
gi|153945761 endothelin converting enzyme 2 isoform A [Homo sapi...   487   e-137
gi|90403592 phosphate-regulating neutral endopeptidase [Homo sap...   480   e-135
gi|157426891 endothelin converting enzyme-like 1 [Homo sapiens]       443   e-124
gi|4557691 Kell blood group, metallo-endopeptidase [Homo sapiens]     216   6e-56
gi|111494235 GRINL1A combined protein isoform 8 [Homo sapiens]         34   0.44 
gi|157364974 sucrase-isomaltase [Homo sapiens]                         34   0.44 
gi|221316699 maltase-glucoamylase [Homo sapiens]                       34   0.57 
gi|16933542 fibronectin 1 isoform 3 preproprotein [Homo sapiens]       34   0.57 
gi|47132557 fibronectin 1 isoform 1 preproprotein [Homo sapiens]       34   0.57 
gi|47132555 fibronectin 1 isoform 4 preproprotein [Homo sapiens]       34   0.57 
gi|47132553 fibronectin 1 isoform 5 preproprotein [Homo sapiens]       34   0.57 
gi|47132551 fibronectin 1 isoform 2 preproprotein [Homo sapiens]       34   0.57 
gi|47132549 fibronectin 1 isoform 6 preproprotein [Homo sapiens]       34   0.57 
gi|4759264 COP9 constitutive photomorphogenic homolog subunit 2 ...    33   0.74 
gi|139948432 adlican [Homo sapiens]                                    33   0.74 
gi|4758104 cytochrome P450, family 7, subfamily B, polypeptide 1...    33   0.97 
gi|14043022 methionyl-tRNA synthetase [Homo sapiens]                   33   0.97 
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]    33   1.3  

>gi|116256333 membrane metallo-endopeptidase [Homo sapiens]
          Length = 750

 Score = 1524 bits (3946), Expect = 0.0
 Identities = 750/750 (100%), Positives = 750/750 (100%)

Query: 1   MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS 60
           MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
Sbjct: 1   MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS 60

Query: 61  DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD 120
           DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
Sbjct: 61  DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD 120

Query: 121 VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA 180
           VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
Sbjct: 121 VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA 180

Query: 181 SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE 240
           SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
Sbjct: 181 SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE 240

Query: 241 ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY 300
           ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
Sbjct: 241 ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY 300

Query: 301 NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT 360
           NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
Sbjct: 301 NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT 360

Query: 361 KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME 420
           KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
Sbjct: 361 KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME 420

Query: 421 NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI 480
           NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
Sbjct: 421 NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI 480

Query: 481 GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA 540
           GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
Sbjct: 481 GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA 540

Query: 541 VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD 600
           VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
Sbjct: 541 VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD 600

Query: 601 GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR 660
           GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
Sbjct: 601 GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR 660

Query: 661 AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII 720
           AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
Sbjct: 661 AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII 720

Query: 721 GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
           GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
Sbjct: 721 GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750


>gi|116256331 membrane metallo-endopeptidase [Homo sapiens]
          Length = 750

 Score = 1524 bits (3946), Expect = 0.0
 Identities = 750/750 (100%), Positives = 750/750 (100%)

Query: 1   MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS 60
           MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
Sbjct: 1   MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS 60

Query: 61  DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD 120
           DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
Sbjct: 61  DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD 120

Query: 121 VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA 180
           VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
Sbjct: 121 VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA 180

Query: 181 SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE 240
           SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
Sbjct: 181 SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE 240

Query: 241 ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY 300
           ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
Sbjct: 241 ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY 300

Query: 301 NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT 360
           NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
Sbjct: 301 NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT 360

Query: 361 KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME 420
           KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
Sbjct: 361 KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME 420

Query: 421 NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI 480
           NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
Sbjct: 421 NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI 480

Query: 481 GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA 540
           GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
Sbjct: 481 GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA 540

Query: 541 VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD 600
           VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
Sbjct: 541 VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD 600

Query: 601 GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR 660
           GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
Sbjct: 601 GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR 660

Query: 661 AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII 720
           AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
Sbjct: 661 AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII 720

Query: 721 GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
           GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
Sbjct: 721 GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750


>gi|116256327 membrane metallo-endopeptidase [Homo sapiens]
          Length = 750

 Score = 1524 bits (3946), Expect = 0.0
 Identities = 750/750 (100%), Positives = 750/750 (100%)

Query: 1   MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS 60
           MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
Sbjct: 1   MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS 60

Query: 61  DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD 120
           DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
Sbjct: 61  DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD 120

Query: 121 VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA 180
           VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
Sbjct: 121 VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA 180

Query: 181 SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE 240
           SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
Sbjct: 181 SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE 240

Query: 241 ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY 300
           ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
Sbjct: 241 ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY 300

Query: 301 NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT 360
           NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
Sbjct: 301 NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT 360

Query: 361 KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME 420
           KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
Sbjct: 361 KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME 420

Query: 421 NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI 480
           NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
Sbjct: 421 NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI 480

Query: 481 GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA 540
           GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
Sbjct: 481 GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA 540

Query: 541 VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD 600
           VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
Sbjct: 541 VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD 600

Query: 601 GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR 660
           GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
Sbjct: 601 GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR 660

Query: 661 AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII 720
           AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
Sbjct: 661 AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII 720

Query: 721 GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
           GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
Sbjct: 721 GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750


>gi|116256329 membrane metallo-endopeptidase [Homo sapiens]
          Length = 750

 Score = 1524 bits (3946), Expect = 0.0
 Identities = 750/750 (100%), Positives = 750/750 (100%)

Query: 1   MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS 60
           MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
Sbjct: 1   MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS 60

Query: 61  DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD 120
           DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
Sbjct: 61  DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD 120

Query: 121 VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA 180
           VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
Sbjct: 121 VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA 180

Query: 181 SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE 240
           SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
Sbjct: 181 SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE 240

Query: 241 ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY 300
           ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
Sbjct: 241 ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY 300

Query: 301 NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT 360
           NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
Sbjct: 301 NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT 360

Query: 361 KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME 420
           KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
Sbjct: 361 KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME 420

Query: 421 NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI 480
           NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
Sbjct: 421 NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI 480

Query: 481 GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA 540
           GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
Sbjct: 481 GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA 540

Query: 541 VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD 600
           VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
Sbjct: 541 VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD 600

Query: 601 GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR 660
           GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
Sbjct: 601 GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR 660

Query: 661 AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII 720
           AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
Sbjct: 661 AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII 720

Query: 721 GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
           GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
Sbjct: 721 GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750


>gi|239049391 membrane metallo-endopeptidase-like 1 [Homo sapiens]
          Length = 779

 Score =  832 bits (2149), Expect = 0.0
 Identities = 382/696 (54%), Positives = 529/696 (76%), Gaps = 5/696 (0%)

Query: 56  ICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELE 115
           +C +  C+ +AAR++QNMD TTEPC DF+++ACGGWL+R+VIPET+SRY  FD+LRDELE
Sbjct: 88  VCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRDELE 147

Query: 116 VVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWE 175
           V+LK VL+    +D  AV+KA+ LYRSC+N+S I+ RG +PLL +L  + GWPVA + W 
Sbjct: 148 VILKAVLENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVGGWPVAMDRWN 207

Query: 176 QKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECT 235
           +  G  W  E+ +A +NS++ ++VLI+LF+  DD+NS  H+I+IDQP LG+PSR+YY   
Sbjct: 208 ETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNG 267

Query: 236 GIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRND 295
           G  ++   AY+ FM+SVA L+R++  LP D   +  +M +V+ELE ++A AT   E+R+D
Sbjct: 268 GSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHD 327

Query: 296 PMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKL 355
            + LY++M L ++Q+ F L    K F+W  F   ++S+V I +  +E+VVVY   YL  L
Sbjct: 328 VIALYHRMGLEELQSQFGL----KGFNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNL 383

Query: 356 KPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYV 415
           + I+  YSAR +QN + WR ++D + SLS+ +K++R  +RKAL+GT  E   WR C  YV
Sbjct: 384 ENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYV 443

Query: 416 NGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALA 475
           N NMENAVG LYV  AF G+SK +V +LI ++R VF++TLD+L WMD E+KK+A+EKA++
Sbjct: 444 NSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEESKKKAQEKAMS 503

Query: 476 IKERIGYPDDIVSNDNK-LNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDE 534
           I+E+IG+PD I+   N+ L+ EY  LN+ ED YFEN +QNLK    + L+KLREKVD + 
Sbjct: 504 IREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSLRKLREKVDPNL 563

Query: 535 WISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNG 594
           WI GAAVVNAFYS  RNQIVFPAGILQPPFFS +Q  +LN+GGIGMVIGHEITHGFDDNG
Sbjct: 564 WIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNG 623

Query: 595 RNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGG 654
           RNF+K+G+++DWW+  S  +F+EQS+CM+YQYGN+SWDLA  Q++NG NTLGENIADNGG
Sbjct: 624 RNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDLADEQNVNGFNTLGENIADNGG 683

Query: 655 LGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSP 714
           + QAY+AY  ++ + G+++ LPGLDL H+QLFF+N+AQVWCG+YRPE+A+ SIKTDVHSP
Sbjct: 684 VRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHSP 743

Query: 715 GNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
             +R++G+LQN A F++ FHC + + M+P+++CRVW
Sbjct: 744 LKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW 779


>gi|164519140 endothelin converting enzyme 1 isoform 2 [Homo
           sapiens]
          Length = 767

 Score =  541 bits (1393), Expect = e-153
 Identities = 290/747 (38%), Positives = 429/747 (57%), Gaps = 32/747 (4%)

Query: 13  INTPKPKKKQR-W---TPLEISLSVLVLLLTIIAVTMIAL----YATYDDGICKSSDCIK 64
           +N   P+  QR W   T +E  L VLV+LL    V  +A     Y T    +C S  C+ 
Sbjct: 44  VNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS 103

Query: 65  SAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQE 124
             + ++ +MD T +PC DFF YACGGW+K N +P+  SR+G F  L +  + ++K +L+ 
Sbjct: 104 VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLEN 163

Query: 125 PKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA 184
                  A +KA+  YR+C+NE+ I+    +PL++L+  + GW + T  W     A    
Sbjct: 164 STASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI-TGPW-----AKDNF 217

Query: 185 EKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTA 244
           +  +  + + Y      +++V  D KNS ++VI +DQ  LGLPSRDYY      ++  T 
Sbjct: 218 QDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTG 277

Query: 245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMT 304
           Y+++M+ + +L+        DE  +  +M ++++ E  +AN T   E R D  L+Y+K+T
Sbjct: 278 YLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 332

Query: 305 LAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSA 364
            A++Q            +WL F N I   V I+    E +VVY  EYL ++  ++     
Sbjct: 333 AAELQTL------APAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDR 384

Query: 365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAV 423
             L N M W  +    S L + ++++   F + +YGT       W+ C +    N+  A+
Sbjct: 385 CLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFAL 444

Query: 424 GRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYP 483
           G ++V+A FA +SK +  ++I +I++ F ++L  L WMD ET+K A+EKA AI   IGYP
Sbjct: 445 GPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 504

Query: 484 DDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543
           + I+ +  +L+  + +     D YFEN ++   FS      +LR+  ++D+W     +VN
Sbjct: 505 NFIM-DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVN 563

Query: 544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603
           A+YS  +N+IVFPAGILQ PF++     +LN+GGIG+V+GHE+TH FDD GR ++KDG+L
Sbjct: 564 AYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 623

Query: 604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQ 663
             WW   S   FK Q++CMV QY N+S     G+ +NG +TLGENIADNGGL  AYRAYQ
Sbjct: 624 RPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRHTLGENIADNGGLKAAYRAYQ 680

Query: 664 NYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL 723
           N++KKNG E  LP L L + QLFFL FAQVWC    PE +   + TD HSP  FR+IG+L
Sbjct: 681 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 740

Query: 724 QNSAEFSEAFHCRKNSYMNPEKKCRVW 750
            NS EFSE F C   S MNP  KC VW
Sbjct: 741 SNSKEFSEHFRCPPGSPMNPPHKCEVW 767


>gi|164519138 endothelin converting enzyme 1 isoform 4 [Homo
           sapiens]
          Length = 754

 Score =  541 bits (1393), Expect = e-153
 Identities = 290/747 (38%), Positives = 429/747 (57%), Gaps = 32/747 (4%)

Query: 13  INTPKPKKKQR-W---TPLEISLSVLVLLLTIIAVTMIAL----YATYDDGICKSSDCIK 64
           +N   P+  QR W   T +E  L VLV+LL    V  +A     Y T    +C S  C+ 
Sbjct: 31  VNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS 90

Query: 65  SAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQE 124
             + ++ +MD T +PC DFF YACGGW+K N +P+  SR+G F  L +  + ++K +L+ 
Sbjct: 91  VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLEN 150

Query: 125 PKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA 184
                  A +KA+  YR+C+NE+ I+    +PL++L+  + GW + T  W     A    
Sbjct: 151 STASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI-TGPW-----AKDNF 204

Query: 185 EKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTA 244
           +  +  + + Y      +++V  D KNS ++VI +DQ  LGLPSRDYY      ++  T 
Sbjct: 205 QDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTG 264

Query: 245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMT 304
           Y+++M+ + +L+        DE  +  +M ++++ E  +AN T   E R D  L+Y+K+T
Sbjct: 265 YLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 319

Query: 305 LAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSA 364
            A++Q            +WL F N I   V I+    E +VVY  EYL ++  ++     
Sbjct: 320 AAELQTL------APAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDR 371

Query: 365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAV 423
             L N M W  +    S L + ++++   F + +YGT       W+ C +    N+  A+
Sbjct: 372 CLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFAL 431

Query: 424 GRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYP 483
           G ++V+A FA +SK +  ++I +I++ F ++L  L WMD ET+K A+EKA AI   IGYP
Sbjct: 432 GPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 491

Query: 484 DDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543
           + I+ +  +L+  + +     D YFEN ++   FS      +LR+  ++D+W     +VN
Sbjct: 492 NFIM-DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVN 550

Query: 544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603
           A+YS  +N+IVFPAGILQ PF++     +LN+GGIG+V+GHE+TH FDD GR ++KDG+L
Sbjct: 551 AYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 610

Query: 604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQ 663
             WW   S   FK Q++CMV QY N+S     G+ +NG +TLGENIADNGGL  AYRAYQ
Sbjct: 611 RPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRHTLGENIADNGGLKAAYRAYQ 667

Query: 664 NYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL 723
           N++KKNG E  LP L L + QLFFL FAQVWC    PE +   + TD HSP  FR+IG+L
Sbjct: 668 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 727

Query: 724 QNSAEFSEAFHCRKNSYMNPEKKCRVW 750
            NS EFSE F C   S MNP  KC VW
Sbjct: 728 SNSKEFSEHFRCPPGSPMNPPHKCEVW 754


>gi|164519136 endothelin converting enzyme 1 isoform 3 [Homo
           sapiens]
          Length = 758

 Score =  541 bits (1393), Expect = e-153
 Identities = 290/747 (38%), Positives = 429/747 (57%), Gaps = 32/747 (4%)

Query: 13  INTPKPKKKQR-W---TPLEISLSVLVLLLTIIAVTMIAL----YATYDDGICKSSDCIK 64
           +N   P+  QR W   T +E  L VLV+LL    V  +A     Y T    +C S  C+ 
Sbjct: 35  VNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS 94

Query: 65  SAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQE 124
             + ++ +MD T +PC DFF YACGGW+K N +P+  SR+G F  L +  + ++K +L+ 
Sbjct: 95  VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLEN 154

Query: 125 PKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA 184
                  A +KA+  YR+C+NE+ I+    +PL++L+  + GW + T  W     A    
Sbjct: 155 STASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI-TGPW-----AKDNF 208

Query: 185 EKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTA 244
           +  +  + + Y      +++V  D KNS ++VI +DQ  LGLPSRDYY      ++  T 
Sbjct: 209 QDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTG 268

Query: 245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMT 304
           Y+++M+ + +L+        DE  +  +M ++++ E  +AN T   E R D  L+Y+K+T
Sbjct: 269 YLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 323

Query: 305 LAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSA 364
            A++Q            +WL F N I   V I+    E +VVY  EYL ++  ++     
Sbjct: 324 AAELQTL------APAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDR 375

Query: 365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAV 423
             L N M W  +    S L + ++++   F + +YGT       W+ C +    N+  A+
Sbjct: 376 CLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFAL 435

Query: 424 GRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYP 483
           G ++V+A FA +SK +  ++I +I++ F ++L  L WMD ET+K A+EKA AI   IGYP
Sbjct: 436 GPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 495

Query: 484 DDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543
           + I+ +  +L+  + +     D YFEN ++   FS      +LR+  ++D+W     +VN
Sbjct: 496 NFIM-DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVN 554

Query: 544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603
           A+YS  +N+IVFPAGILQ PF++     +LN+GGIG+V+GHE+TH FDD GR ++KDG+L
Sbjct: 555 AYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 614

Query: 604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQ 663
             WW   S   FK Q++CMV QY N+S     G+ +NG +TLGENIADNGGL  AYRAYQ
Sbjct: 615 RPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRHTLGENIADNGGLKAAYRAYQ 671

Query: 664 NYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL 723
           N++KKNG E  LP L L + QLFFL FAQVWC    PE +   + TD HSP  FR+IG+L
Sbjct: 672 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 731

Query: 724 QNSAEFSEAFHCRKNSYMNPEKKCRVW 750
            NS EFSE F C   S MNP  KC VW
Sbjct: 732 SNSKEFSEHFRCPPGSPMNPPHKCEVW 758


>gi|4503443 endothelin converting enzyme 1 isoform 1 [Homo sapiens]
          Length = 770

 Score =  541 bits (1393), Expect = e-153
 Identities = 290/747 (38%), Positives = 429/747 (57%), Gaps = 32/747 (4%)

Query: 13  INTPKPKKKQR-W---TPLEISLSVLVLLLTIIAVTMIAL----YATYDDGICKSSDCIK 64
           +N   P+  QR W   T +E  L VLV+LL    V  +A     Y T    +C S  C+ 
Sbjct: 47  VNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS 106

Query: 65  SAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQE 124
             + ++ +MD T +PC DFF YACGGW+K N +P+  SR+G F  L +  + ++K +L+ 
Sbjct: 107 VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLEN 166

Query: 125 PKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA 184
                  A +KA+  YR+C+NE+ I+    +PL++L+  + GW + T  W     A    
Sbjct: 167 STASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI-TGPW-----AKDNF 220

Query: 185 EKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTA 244
           +  +  + + Y      +++V  D KNS ++VI +DQ  LGLPSRDYY      ++  T 
Sbjct: 221 QDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTG 280

Query: 245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMT 304
           Y+++M+ + +L+        DE  +  +M ++++ E  +AN T   E R D  L+Y+K+T
Sbjct: 281 YLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 335

Query: 305 LAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSA 364
            A++Q            +WL F N I   V I+    E +VVY  EYL ++  ++     
Sbjct: 336 AAELQTL------APAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDR 387

Query: 365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAV 423
             L N M W  +    S L + ++++   F + +YGT       W+ C +    N+  A+
Sbjct: 388 CLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFAL 447

Query: 424 GRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYP 483
           G ++V+A FA +SK +  ++I +I++ F ++L  L WMD ET+K A+EKA AI   IGYP
Sbjct: 448 GPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 507

Query: 484 DDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543
           + I+ +  +L+  + +     D YFEN ++   FS      +LR+  ++D+W     +VN
Sbjct: 508 NFIM-DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVN 566

Query: 544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603
           A+YS  +N+IVFPAGILQ PF++     +LN+GGIG+V+GHE+TH FDD GR ++KDG+L
Sbjct: 567 AYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 626

Query: 604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQ 663
             WW   S   FK Q++CMV QY N+S     G+ +NG +TLGENIADNGGL  AYRAYQ
Sbjct: 627 RPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRHTLGENIADNGGLKAAYRAYQ 683

Query: 664 NYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL 723
           N++KKNG E  LP L L + QLFFL FAQVWC    PE +   + TD HSP  FR+IG+L
Sbjct: 684 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 743

Query: 724 QNSAEFSEAFHCRKNSYMNPEKKCRVW 750
            NS EFSE F C   S MNP  KC VW
Sbjct: 744 SNSKEFSEHFRCPPGSPMNPPHKCEVW 770


>gi|153945836 endothelin converting enzyme 2 isoform E [Homo
           sapiens]
          Length = 765

 Score =  487 bits (1254), Expect = e-137
 Identities = 263/733 (35%), Positives = 412/733 (56%), Gaps = 31/733 (4%)

Query: 25  TPLEISLSVLVLLLTIIAV-TMIALYATY----DDGICKSSDCIKSAARLIQNMDATTEP 79
           T LE+ L+   LLL  + +  ++AL   Y        C +  CI+ A ++++++D    P
Sbjct: 57  TQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSP 116

Query: 80  CTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPK-TEDIVAVQKAKA 138
           C DF++++CGGW++RN +P+  SR+  F+ L D+ + +LK +L+         A QK + 
Sbjct: 117 CEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQR 176

Query: 139 LYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKK 198
            Y SC+    I+  G +PL  L+  I GW + T  W+Q         KA+A     Y   
Sbjct: 177 FYLSCLQVERIEELGAQPLRDLIEKIGGWNI-TGPWDQDNFME--VLKAVA---GTYRAT 230

Query: 199 VLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQ 258
               +++  D K+S ++VI +DQ  L LPSRDYY      ++  TAY+D+M  +  L+  
Sbjct: 231 PFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGG 290

Query: 259 EERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEING 318
               P    +   +M +V+ELE ++AN T   + R D   +Y+KM+++++Q         
Sbjct: 291 R---PTSTRE---QMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ------ALA 338

Query: 319 KPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMD 378
               WL F + ++S + +S  + E VVVY  +YL ++  ++ +     L N + W  +  
Sbjct: 339 PSMDWLEFLSFLLSPLELS--DSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQK 396

Query: 379 LVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAVGRLYVEAAFAGESK 437
             SSL R ++ ++    + LYGT       W+ C +  +  +  A+G L+V+A F  +SK
Sbjct: 397 TTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSK 456

Query: 438 HVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEY 497
            + E +I++IR  F + L  L WMD +T++ A+EKA AI + IG+PD I+    +L++ Y
Sbjct: 457 EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILE-PKELDDVY 515

Query: 498 LELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPA 557
                 ED +F+N++    FS      +LR+   +D+W      VNA+Y   +N+IVFPA
Sbjct: 516 DGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPA 575

Query: 558 GILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKE 617
           GILQ PF++     +LN+GGIG+V+GHE+TH FDD GR ++K+G+L  WW  +S + F+ 
Sbjct: 576 GILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRN 635

Query: 618 QSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPG 677
            + CM  QY  +      G+ LNG  TLGENIADNGGL  AY AY+ +++K+GEE+ LP 
Sbjct: 636 HTACMEEQYNQYQ---VNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPA 692

Query: 678 LDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRK 737
           + L + QLFF+ FAQVWC    PE +   + TD HSP  FR++GTL NS +F   F C  
Sbjct: 693 VGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPV 752

Query: 738 NSYMNPEKKCRVW 750
            S MNP + C VW
Sbjct: 753 GSPMNPGQLCEVW 765


>gi|153945771 endothelin converting enzyme 2 isoform D [Homo
           sapiens]
          Length = 811

 Score =  487 bits (1254), Expect = e-137
 Identities = 263/733 (35%), Positives = 412/733 (56%), Gaps = 31/733 (4%)

Query: 25  TPLEISLSVLVLLLTIIAV-TMIALYATY----DDGICKSSDCIKSAARLIQNMDATTEP 79
           T LE+ L+   LLL  + +  ++AL   Y        C +  CI+ A ++++++D    P
Sbjct: 103 TQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSP 162

Query: 80  CTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPK-TEDIVAVQKAKA 138
           C DF++++CGGW++RN +P+  SR+  F+ L D+ + +LK +L+         A QK + 
Sbjct: 163 CEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQR 222

Query: 139 LYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKK 198
            Y SC+    I+  G +PL  L+  I GW + T  W+Q         KA+A     Y   
Sbjct: 223 FYLSCLQVERIEELGAQPLRDLIEKIGGWNI-TGPWDQDNFME--VLKAVA---GTYRAT 276

Query: 199 VLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQ 258
               +++  D K+S ++VI +DQ  L LPSRDYY      ++  TAY+D+M  +  L+  
Sbjct: 277 PFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGG 336

Query: 259 EERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEING 318
               P    +   +M +V+ELE ++AN T   + R D   +Y+KM+++++Q         
Sbjct: 337 R---PTSTRE---QMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ------ALA 384

Query: 319 KPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMD 378
               WL F + ++S + +S  + E VVVY  +YL ++  ++ +     L N + W  +  
Sbjct: 385 PSMDWLEFLSFLLSPLELS--DSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQK 442

Query: 379 LVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAVGRLYVEAAFAGESK 437
             SSL R ++ ++    + LYGT       W+ C +  +  +  A+G L+V+A F  +SK
Sbjct: 443 TTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSK 502

Query: 438 HVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEY 497
            + E +I++IR  F + L  L WMD +T++ A+EKA AI + IG+PD I+    +L++ Y
Sbjct: 503 EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILE-PKELDDVY 561

Query: 498 LELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPA 557
                 ED +F+N++    FS      +LR+   +D+W      VNA+Y   +N+IVFPA
Sbjct: 562 DGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPA 621

Query: 558 GILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKE 617
           GILQ PF++     +LN+GGIG+V+GHE+TH FDD GR ++K+G+L  WW  +S + F+ 
Sbjct: 622 GILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRN 681

Query: 618 QSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPG 677
            + CM  QY  +      G+ LNG  TLGENIADNGGL  AY AY+ +++K+GEE+ LP 
Sbjct: 682 HTACMEEQYNQYQ---VNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPA 738

Query: 678 LDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRK 737
           + L + QLFF+ FAQVWC    PE +   + TD HSP  FR++GTL NS +F   F C  
Sbjct: 739 VGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPV 798

Query: 738 NSYMNPEKKCRVW 750
            S MNP + C VW
Sbjct: 799 GSPMNPGQLCEVW 811


>gi|82617560 endothelin converting enzyme 2 isoform B [Homo sapiens]
          Length = 736

 Score =  487 bits (1254), Expect = e-137
 Identities = 263/733 (35%), Positives = 412/733 (56%), Gaps = 31/733 (4%)

Query: 25  TPLEISLSVLVLLLTIIAV-TMIALYATY----DDGICKSSDCIKSAARLIQNMDATTEP 79
           T LE+ L+   LLL  + +  ++AL   Y        C +  CI+ A ++++++D    P
Sbjct: 28  TQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSP 87

Query: 80  CTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPK-TEDIVAVQKAKA 138
           C DF++++CGGW++RN +P+  SR+  F+ L D+ + +LK +L+         A QK + 
Sbjct: 88  CEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQR 147

Query: 139 LYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKK 198
            Y SC+    I+  G +PL  L+  I GW + T  W+Q         KA+A     Y   
Sbjct: 148 FYLSCLQVERIEELGAQPLRDLIEKIGGWNI-TGPWDQDNFME--VLKAVA---GTYRAT 201

Query: 199 VLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQ 258
               +++  D K+S ++VI +DQ  L LPSRDYY      ++  TAY+D+M  +  L+  
Sbjct: 202 PFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGG 261

Query: 259 EERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEING 318
               P    +   +M +V+ELE ++AN T   + R D   +Y+KM+++++Q         
Sbjct: 262 R---PTSTRE---QMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ------ALA 309

Query: 319 KPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMD 378
               WL F + ++S + +S  + E VVVY  +YL ++  ++ +     L N + W  +  
Sbjct: 310 PSMDWLEFLSFLLSPLELS--DSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQK 367

Query: 379 LVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAVGRLYVEAAFAGESK 437
             SSL R ++ ++    + LYGT       W+ C +  +  +  A+G L+V+A F  +SK
Sbjct: 368 TTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSK 427

Query: 438 HVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEY 497
            + E +I++IR  F + L  L WMD +T++ A+EKA AI + IG+PD I+    +L++ Y
Sbjct: 428 EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILE-PKELDDVY 486

Query: 498 LELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPA 557
                 ED +F+N++    FS      +LR+   +D+W      VNA+Y   +N+IVFPA
Sbjct: 487 DGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPA 546

Query: 558 GILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKE 617
           GILQ PF++     +LN+GGIG+V+GHE+TH FDD GR ++K+G+L  WW  +S + F+ 
Sbjct: 547 GILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRN 606

Query: 618 QSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPG 677
            + CM  QY  +      G+ LNG  TLGENIADNGGL  AY AY+ +++K+GEE+ LP 
Sbjct: 607 HTACMEEQYNQYQ---VNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPA 663

Query: 678 LDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRK 737
           + L + QLFF+ FAQVWC    PE +   + TD HSP  FR++GTL NS +F   F C  
Sbjct: 664 VGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPV 723

Query: 738 NSYMNPEKKCRVW 750
            S MNP + C VW
Sbjct: 724 GSPMNPGQLCEVW 736


>gi|153945761 endothelin converting enzyme 2 isoform A [Homo
           sapiens]
          Length = 883

 Score =  487 bits (1254), Expect = e-137
 Identities = 263/733 (35%), Positives = 412/733 (56%), Gaps = 31/733 (4%)

Query: 25  TPLEISLSVLVLLLTIIAV-TMIALYATY----DDGICKSSDCIKSAARLIQNMDATTEP 79
           T LE+ L+   LLL  + +  ++AL   Y        C +  CI+ A ++++++D    P
Sbjct: 175 TQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSP 234

Query: 80  CTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPK-TEDIVAVQKAKA 138
           C DF++++CGGW++RN +P+  SR+  F+ L D+ + +LK +L+         A QK + 
Sbjct: 235 CEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQR 294

Query: 139 LYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKK 198
            Y SC+    I+  G +PL  L+  I GW + T  W+Q         KA+A     Y   
Sbjct: 295 FYLSCLQVERIEELGAQPLRDLIEKIGGWNI-TGPWDQDNFME--VLKAVA---GTYRAT 348

Query: 199 VLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQ 258
               +++  D K+S ++VI +DQ  L LPSRDYY      ++  TAY+D+M  +  L+  
Sbjct: 349 PFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGG 408

Query: 259 EERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEING 318
               P    +   +M +V+ELE ++AN T   + R D   +Y+KM+++++Q         
Sbjct: 409 R---PTSTRE---QMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ------ALA 456

Query: 319 KPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMD 378
               WL F + ++S + +S  + E VVVY  +YL ++  ++ +     L N + W  +  
Sbjct: 457 PSMDWLEFLSFLLSPLELS--DSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQK 514

Query: 379 LVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAVGRLYVEAAFAGESK 437
             SSL R ++ ++    + LYGT       W+ C +  +  +  A+G L+V+A F  +SK
Sbjct: 515 TTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSK 574

Query: 438 HVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEY 497
            + E +I++IR  F + L  L WMD +T++ A+EKA AI + IG+PD I+    +L++ Y
Sbjct: 575 EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILE-PKELDDVY 633

Query: 498 LELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPA 557
                 ED +F+N++    FS      +LR+   +D+W      VNA+Y   +N+IVFPA
Sbjct: 634 DGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPA 693

Query: 558 GILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKE 617
           GILQ PF++     +LN+GGIG+V+GHE+TH FDD GR ++K+G+L  WW  +S + F+ 
Sbjct: 694 GILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRN 753

Query: 618 QSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPG 677
            + CM  QY  +      G+ LNG  TLGENIADNGGL  AY AY+ +++K+GEE+ LP 
Sbjct: 754 HTACMEEQYNQYQ---VNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPA 810

Query: 678 LDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRK 737
           + L + QLFF+ FAQVWC    PE +   + TD HSP  FR++GTL NS +F   F C  
Sbjct: 811 VGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPV 870

Query: 738 NSYMNPEKKCRVW 750
            S MNP + C VW
Sbjct: 871 GSPMNPGQLCEVW 883


>gi|90403592 phosphate-regulating neutral endopeptidase [Homo
           sapiens]
          Length = 749

 Score =  480 bits (1236), Expect = e-135
 Identities = 265/738 (35%), Positives = 417/738 (56%), Gaps = 40/738 (5%)

Query: 33  VLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWL 92
           VL  +L +++  +++L A  +   C   +CI++AA ++  ++ + +PC +FF++AC GW+
Sbjct: 32  VLGTILFLVSQGLLSLQAKQE--YCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWI 89

Query: 93  KRNVIPETSSRYGNFDILRDELEVVLKDVLQEP--KTEDIVAVQKAKALYRSCINESAID 150
             N IPE    YG +  LR  +++ LK++L++   +  D  A+QKAK LY SC+NE AI+
Sbjct: 90  SNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIE 149

Query: 151 SRGGEPLLKLLPDI-YGWPVATEN------WEQKYGASWTAEKAIAQLNSKYGKKVLINL 203
               +PLL +L    + WPV   N      W ++    ++  + +A    +Y   V I L
Sbjct: 150 KADAKPLLHILRHSPFRWPVLESNIGPEGVWSER---KFSLLQTLATFRGQYSNSVFIRL 206

Query: 204 FVGTDDKNSVNHVIHIDQPRLGLPSR-DYYECTGIYKEACTAYVDFMISVARLIRQEERL 262
           +V  DDK S  H++ +DQ  L L  R DY + +   K    A   FM+  A L      L
Sbjct: 207 YVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVL------L 260

Query: 263 PIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFS 322
             + ++   +M  V+ LE +IA      E+R    + YNKM ++++            F 
Sbjct: 261 GANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAM-YNKMNISELSAMIP------QFD 313

Query: 323 WLNFTNEIMSTVNI----SITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMD 378
           WL +  +++ T        I+  E+VVV  P+Y   L  IL     + + N + WR +  
Sbjct: 314 WLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYS 373

Query: 379 LVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKH 438
            + +LSR ++     F + + GTT+    W +C N++   +   VG+++V+  F  + K 
Sbjct: 374 RIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKE 433

Query: 439 VVEDLIAQIREVFIQTLD-DLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEY 497
           ++E+L+  +R  FI  L+ +  WMDA TK++A+EKA A+  ++GYP+ I+ ND  +N + 
Sbjct: 434 MMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIM-NDTHVNEDL 492

Query: 498 LELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPA 557
             + + E +YF N++Q  K+        LR+ V K EW +    VNAFYS+  NQI FPA
Sbjct: 493 KAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPA 552

Query: 558 GILQPPFF-SAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFK 616
           G LQ PFF   +   SL+YG IG+++GHE THGFD+NGR ++K+G+L  WW+ +S   FK
Sbjct: 553 GELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFK 612

Query: 617 EQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYI---KKNGEEK 673
           E+++CM+ QY N+ W  A G ++ G  TLGENIADNGGL +A+RAY+ +I   ++  EE 
Sbjct: 613 EKTKCMINQYSNYYWKKA-GLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEP 671

Query: 674 LLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAF 733
           LLPG+   + QLFFL++A V C +YRPE A   ++   HSP  FR+ G + N  EF +AF
Sbjct: 672 LLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAF 731

Query: 734 HCRKNSYMN-PEKKCRVW 750
           +C  NS MN     CR+W
Sbjct: 732 NCPPNSTMNRGMDSCRLW 749


>gi|157426891 endothelin converting enzyme-like 1 [Homo sapiens]
          Length = 775

 Score =  443 bits (1140), Expect = e-124
 Identities = 257/744 (34%), Positives = 390/744 (52%), Gaps = 38/744 (5%)

Query: 23  RWTPLEISL-SVLVLLLTIIAVTMIALYATYDDGI----------CKSSDCIKSAAR-LI 70
           RW   E+ L S LV    + A+    L   Y   +          C        AAR L 
Sbjct: 54  RWNRREVCLLSGLVFAAGLCAILAAMLALKYLGPVAAGGGACPEGCPERKAFARAARFLA 113

Query: 71  QNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDI 130
            N+DA+ +PC DF+ +ACGGWL+R+ IP+    YG    + ++ E  L+ +L  P     
Sbjct: 114 ANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPGGGPG 173

Query: 131 VAVQ-KAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIA 189
            A Q K +A +RSC++   I+  G  P+L+++ D  GW +          A W   + + 
Sbjct: 174 GAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAEERPGVAARWDLNRLLY 233

Query: 190 QLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEAC-TAYVDF 248
           +    Y    L +L V  DD+NS  +VI IDQ  L LP R  Y       E    AY  F
Sbjct: 234 KAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEDSEKILAAYRVF 293

Query: 249 MISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPED--RNDPMLLYNKMTLA 306
           M  V  L+  +         +  +  +++++E+++AN T    D  R D   +YNK+TL 
Sbjct: 294 MERVLSLLGADA--------VEQKAQEILQVEQQLANITVSEHDDLRRDVSSMYNKVTLG 345

Query: 307 QIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARD 366
           Q+Q             W    ++I        + EE+VV+ A +Y+ ++  ++     R 
Sbjct: 346 QLQKITP------HLRWKWLLDQIFQE---DFSEEEEVVLLATDYMQQVSQLIRSTPHRV 396

Query: 367 LQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRL 426
           L N + WR ++ L   LS  ++E+ +   + + G+       R C    N +   A+G L
Sbjct: 397 LHNYLVWRVVVVLSEHLSPPFREALHELAQEMEGSDKPQELARVCLGQANRHFGMALGAL 456

Query: 427 YVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDI 486
           +V   F+  SK  V+ L+  I+ +  Q L++L WMDAET+  A  K   +   +GYPD +
Sbjct: 457 FVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAKLQYMMVMVGYPDFL 516

Query: 487 VSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFY 546
           +  D  ++ EY E    E  YF+NI+ +++FS    +KK+R++VDK  W+     +NA+Y
Sbjct: 517 LKPD-AVDKEY-EFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTWLLPPQALNAYY 574

Query: 547 SSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDW 606
              +NQ+VFPAGILQP  +      SLNYGGIG +IGHE+THG+DD G  +++ G+L+ W
Sbjct: 575 LPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHW 634

Query: 607 WTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYI 666
           WT+ S S F  +++C+V  Y NF+      Q +NG +TLGENIAD GGL  AY AYQ ++
Sbjct: 635 WTEASYSRFLRKAECIVRLYDNFT---VYNQRVNGKHTLGENIADMGGLKLAYHAYQKWV 691

Query: 667 KKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNS 726
           +++G E  LP L   H QLFF+ FAQ WC   R +     + TD H+P ++R++G++   
Sbjct: 692 REHGPEHPLPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQF 751

Query: 727 AEFSEAFHCRKNSYMNPEKKCRVW 750
            EF  AFHC K+S MNP  KC VW
Sbjct: 752 EEFGRAFHCPKDSPMNPAHKCSVW 775


>gi|4557691 Kell blood group, metallo-endopeptidase [Homo sapiens]
          Length = 732

 Score =  216 bits (550), Expect = 6e-56
 Identities = 173/749 (23%), Positives = 332/749 (44%), Gaps = 80/749 (10%)

Query: 24  WTPLEISLSVLVLLLTIIAVTMIALYATYDDGI--CKSSDCIKSAARLIQNMDATTEPCT 81
           W      L+ +++L  ++  +++  Y   + G   C++S C+      + + + +  PCT
Sbjct: 42  WAVARRVLTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCT 101

Query: 82  DFFKYACGGWLK-RNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALY 140
           DFF +ACG   +  N   E +++  N + LR  LEV       +         +KA   Y
Sbjct: 102 DFFSFACGRAKETNNSFQELATK--NKNRLRRILEV-------QNSWHPGSGEEKAFQFY 152

Query: 141 RSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA---EKAIAQLNSKYGK 197
            SC++  AI++ G  PL +++ ++ GW ++           WT+    + +  L S+YG 
Sbjct: 153 NSCMDTLAIEAAGTGPLRQVIEELGGWRIS---------GKWTSLNFNRTLRLLMSQYGH 203

Query: 198 KVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIR 257
                 ++G    +    VI IDQP   +P +   E   IY +    Y+ ++  +  L+ 
Sbjct: 204 FPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQE-QKIYAQIFREYLTYLNQLGTLLG 262

Query: 258 QEERLPIDENQLALEM-NKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEI 316
            +     + + L++ + +++ +  + +       E R     L+  +T+ Q++       
Sbjct: 263 GDPSKVQEHSSLSISITSRLFQFLRPL-------EQRRAQGKLFQMVTIDQLKEM----- 310

Query: 317 NGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARD---LQNLMSW 373
                 WL+      + +++S +  + +VV+  EYL  +  ++ +   +    LQ+ M  
Sbjct: 311 -APAIDWLSCLQATFTPMSLSPS--QSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMIL 367

Query: 374 RFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-----WRRCANYVNGNMENAVGRLYV 428
             ++ L  +L   ++E+R    + L   T +        W +C        E  +  L+V
Sbjct: 368 GLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFV 427

Query: 429 EAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVS 488
             AF   ++     L   IR+  I  L +L WM+ ET+  A++K   ++  +G      +
Sbjct: 428 REAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMG------A 481

Query: 489 NDNKLNNEYLELNYKE----DEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNA 544
           ++  L  E     Y +      + ++++  ++  +++ ++   +   +  W      VNA
Sbjct: 482 SEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVNA 541

Query: 545 FYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDD---NGRNFNKDG 601
           +YS   + +VFPAG+LQPPFF      ++N+G  G ++ HE+ H F      G     D 
Sbjct: 542 YYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACDN 601

Query: 602 DLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRA 661
             +           +E   C+   Y  F   L      N   T  EN AD GGL  A +A
Sbjct: 602 HAL-----------QEAHLCLKRHYAAF--PLPSRTSFNDSLTFLENAADVGGLAIALQA 648

Query: 662 YQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIG 721
           Y   + ++  E +LP LDL+ +Q+FF ++AQV C    P+ +      D HSP + R+ G
Sbjct: 649 YSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDS-----HDTHSPPHLRVHG 703

Query: 722 TLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
            L ++  F+  F C + + +NP  +C++W
Sbjct: 704 PLSSTPAFARYFRCARGALLNPSSRCQLW 732


>gi|111494235 GRINL1A combined protein isoform 8 [Homo sapiens]
          Length = 438

 Score = 34.3 bits (77), Expect = 0.44
 Identities = 31/132 (23%), Positives = 62/132 (46%), Gaps = 11/132 (8%)

Query: 404 ETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLD------- 456
           ET ++ +     N  M+ A   L  +    GE   ++E +  +  ++ +Q L+       
Sbjct: 270 ETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSG 329

Query: 457 DLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLK 516
           +LT  D E  ++ EE + +++ERI + DD+V    K   + +E    E+   ++ +  L 
Sbjct: 330 ELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVE----ENNELQSRLDYLT 385

Query: 517 FSQSKQLKKLRE 528
            +Q+K   + RE
Sbjct: 386 ETQAKTEVETRE 397


>gi|157364974 sucrase-isomaltase [Homo sapiens]
          Length = 1827

 Score = 34.3 bits (77), Expect = 0.44
 Identities = 17/47 (36%), Positives = 31/47 (65%)

Query: 21 KQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAA 67
          +++++ LEISL VL +++TIIA+ +I + AT    + + SD   + A
Sbjct: 3  RKKFSGLEISLIVLFVIVTIIAIALIVVLATKTPAVDEISDSTSTPA 49


>gi|221316699 maltase-glucoamylase [Homo sapiens]
          Length = 1857

 Score = 33.9 bits (76), Expect = 0.57
 Identities = 17/32 (53%), Positives = 25/32 (78%)

Query: 19 KKKQRWTPLEISLSVLVLLLTIIAVTMIALYA 50
          KK +++T LEI LSVL+L+L II++ +I L A
Sbjct: 4  KKLKKFTTLEIVLSVLLLVLFIISIVLIVLLA 35


>gi|16933542 fibronectin 1 isoform 3 preproprotein [Homo sapiens]
          Length = 2355

 Score = 33.9 bits (76), Expect = 0.57
 Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 1/54 (1%)

Query: 605  DWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGIN-TLGENIADNGGLGQ 657
            D W + S S FK   QC+ +  G+F  D +   H NG+N  +GE     G  GQ
Sbjct: 2188 DEWERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQ 2241


>gi|47132557 fibronectin 1 isoform 1 preproprotein [Homo sapiens]
          Length = 2477

 Score = 33.9 bits (76), Expect = 0.57
 Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 1/54 (1%)

Query: 605  DWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGIN-TLGENIADNGGLGQ 657
            D W + S S FK   QC+ +  G+F  D +   H NG+N  +GE     G  GQ
Sbjct: 2310 DEWERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQ 2363


>gi|47132555 fibronectin 1 isoform 4 preproprotein [Homo sapiens]
          Length = 2330

 Score = 33.9 bits (76), Expect = 0.57
 Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 1/54 (1%)

Query: 605  DWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGIN-TLGENIADNGGLGQ 657
            D W + S S FK   QC+ +  G+F  D +   H NG+N  +GE     G  GQ
Sbjct: 2163 DEWERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQ 2216


>gi|47132553 fibronectin 1 isoform 5 preproprotein [Homo sapiens]
          Length = 2296

 Score = 33.9 bits (76), Expect = 0.57
 Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 1/54 (1%)

Query: 605  DWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGIN-TLGENIADNGGLGQ 657
            D W + S S FK   QC+ +  G+F  D +   H NG+N  +GE     G  GQ
Sbjct: 2129 DEWERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQ 2182


>gi|47132551 fibronectin 1 isoform 2 preproprotein [Homo sapiens]
          Length = 2421

 Score = 33.9 bits (76), Expect = 0.57
 Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 1/54 (1%)

Query: 605  DWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGIN-TLGENIADNGGLGQ 657
            D W + S S FK   QC+ +  G+F  D +   H NG+N  +GE     G  GQ
Sbjct: 2254 DEWERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQ 2307


>gi|47132549 fibronectin 1 isoform 6 preproprotein [Homo sapiens]
          Length = 2176

 Score = 33.9 bits (76), Expect = 0.57
 Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 1/54 (1%)

Query: 605  DWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGIN-TLGENIADNGGLGQ 657
            D W + S S FK   QC+ +  G+F  D +   H NG+N  +GE     G  GQ
Sbjct: 2009 DEWERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQ 2062


>gi|4759264 COP9 constitutive photomorphogenic homolog subunit 2
           isoform 1 [Homo sapiens]
          Length = 443

 Score = 33.5 bits (75), Expect = 0.74
 Identities = 46/224 (20%), Positives = 90/224 (40%), Gaps = 39/224 (17%)

Query: 277 MELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNI 336
           ++LE +  N+ A  ED  DP     K  L+  Q    LE+ G+   W     + M  +N 
Sbjct: 30  VDLENQYYNSKALKED--DP-----KAALSSFQK--VLELEGEKGEWGFKALKQMIKINF 80

Query: 337 SITNEEDVVVYAPEYLTKLKPILTK-YSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFR 395
            +TN  +++    + LT ++  +T+ YS + + +++ +      +  L   Y+ +  A +
Sbjct: 81  KLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYISTSKQMDLLQEFYETTLEALK 140

Query: 396 KALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLI----------- 444
            A          W +            +G+LY+E    G+ + ++  L            
Sbjct: 141 DA-----KNDRLWFK--------TNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDGEDD 187

Query: 445 ----AQIREVFIQTLDDLTWMDAETKKRA-EEKALAIKERIGYP 483
                Q+ E++   +   T      K +A  E++L IK  I +P
Sbjct: 188 LKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHP 231


>gi|139948432 adlican [Homo sapiens]
          Length = 2828

 Score = 33.5 bits (75), Expect = 0.74
 Identities = 16/30 (53%), Positives = 18/30 (60%), Gaps = 1/30 (3%)

Query: 627  GNFSWDLAGGQHLNGINTLGE-NIADNGGL 655
            G FSW L  G HL G  TLG  ++ DNG L
Sbjct: 2667 GRFSWTLPNGMHLEGPQTLGRVSLLDNGTL 2696


>gi|4758104 cytochrome P450, family 7, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 506

 Score = 33.1 bits (74), Expect = 0.97
 Identities = 24/95 (25%), Positives = 43/95 (45%), Gaps = 1/95 (1%)

Query: 439 VVEDLIAQIREVFI-QTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEY 497
           ++E ++  +++VF  Q L   +W  AE           I     Y   IV ++NK  +E 
Sbjct: 153 LLESMMQNLKQVFEPQLLKTTSWDTAELYPFCSSIIFEITFTTIYGKVIVCDNNKFISEL 212

Query: 498 LELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDK 532
            +   K D+ F  ++ N+       +K +REK+ K
Sbjct: 213 RDDFLKFDDKFAYLVSNIPIELLGNVKSIREKIIK 247


>gi|14043022 methionyl-tRNA synthetase [Homo sapiens]
          Length = 900

 Score = 33.1 bits (74), Expect = 0.97
 Identities = 14/49 (28%), Positives = 31/49 (63%)

Query: 244 AYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPED 292
           A +D +     ++R+ +    D+N++A E+ K+++L+K++A A  KP +
Sbjct: 844 ALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPE 892


>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
          Length = 971

 Score = 32.7 bits (73), Expect = 1.3
 Identities = 21/102 (20%), Positives = 52/102 (50%), Gaps = 1/102 (0%)

Query: 440 VEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLE 499
           +E+ + Q+ E   +TL++L W      +     A+  K+++    +   N +KLN E  +
Sbjct: 348 LEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDK 407

Query: 500 LNYKED-EYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA 540
              +++ E  + ++++   + ++++  L++ V K E   G+A
Sbjct: 408 NQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSA 449


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,470,328
Number of Sequences: 37866
Number of extensions: 1197793
Number of successful extensions: 3094
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 2986
Number of HSP's gapped (non-prelim): 60
length of query: 750
length of database: 18,247,518
effective HSP length: 110
effective length of query: 640
effective length of database: 14,082,258
effective search space: 9012645120
effective search space used: 9012645120
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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