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Search of human proteins with 23238222
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23238222 COP9 constitutive photomorphogenic homolog subunit
3 [Homo sapiens]
(423 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23238222 COP9 constitutive photomorphogenic homolog subunit 3... 845 0.0
gi|25777612 proteasome 26S non-ATPase subunit 3 [Homo sapiens] 69 8e-12
gi|4506221 proteasome 26S non-ATPase subunit 12 isoform 1 [Homo ... 33 0.64
gi|28872765 proteasome 26S non-ATPase subunit 12 isoform 2 [Homo... 33 0.64
gi|38373690 COP9 signalosome subunit 4 [Homo sapiens] 32 1.4
gi|205277441 serine (or cysteine) proteinase inhibitor, clade A,... 31 1.9
gi|4503521 eukaryotic translation initiation factor 3, subunit 6... 31 2.4
gi|239751459 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s... 30 3.2
gi|239745966 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s... 30 3.2
gi|23957690 component of oligomeric golgi complex 7 [Homo sapiens] 30 5.4
gi|21361787 tetratricopeptide repeat domain 17 [Homo sapiens] 29 7.1
gi|239754279 PREDICTED: hypothetical protein XP_002345940 [Homo ... 29 9.2
gi|239748812 PREDICTED: hypothetical protein XP_002346807 [Homo ... 29 9.2
gi|239740912 PREDICTED: hypothetical protein XP_002344084 [Homo ... 29 9.2
gi|239740849 PREDICTED: hypothetical protein XP_002344051 [Homo ... 29 9.2
>gi|23238222 COP9 constitutive photomorphogenic homolog subunit 3
[Homo sapiens]
Length = 423
Score = 845 bits (2182), Expect = 0.0
Identities = 423/423 (100%), Positives = 423/423 (100%)
Query: 1 MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLA 60
MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLA
Sbjct: 1 MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLA 60
Query: 61 VLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRG 120
VLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRG
Sbjct: 61 VLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRG 120
Query: 121 IGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKH 180
IGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKH
Sbjct: 121 IGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKH 180
Query: 181 FLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQ 240
FLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQ
Sbjct: 181 FLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQ 240
Query: 241 LPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLS 300
LPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLS
Sbjct: 241 LPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLS 300
Query: 301 SLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSF 360
SLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSF
Sbjct: 301 SLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSF 360
Query: 361 HDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPS 420
HDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPS
Sbjct: 361 HDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPS 420
Query: 421 SYS 423
SYS
Sbjct: 421 SYS 423
>gi|25777612 proteasome 26S non-ATPase subunit 3 [Homo sapiens]
Length = 534
Score = 68.9 bits (167), Expect = 8e-12
Identities = 54/231 (23%), Positives = 103/231 (44%), Gaps = 9/231 (3%)
Query: 184 YYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPK 243
Y YY G I + A A+ + ++ K ++V +LLG++ +
Sbjct: 288 YLYYTGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQ 347
Query: 244 YTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLY 303
+ + R + P Y L Q T N ++ ++++ E F D L+ + ++
Sbjct: 348 FRQPSLKRSLMP----YFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVI 403
Query: 304 KKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDN 363
K ++ ++ ++ +SL D+A ++QL P++AE V I DG I ASIN + G V +
Sbjct: 404 KTGVRMISLSYSRISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEM 463
Query: 364 PEKYNNPAMLHNIDQEMLKCIEL-DERLKAMDQEITVNPQFVQKSMGSQED 413
+ Y+ Q + C+++ + +KAM P+ K + S E+
Sbjct: 464 IDIYSTREPQLAFHQRISFCLDIHNMSVKAM----RFPPKSYNKDLESAEE 510
>gi|4506221 proteasome 26S non-ATPase subunit 12 isoform 1 [Homo
sapiens]
Length = 456
Score = 32.7 bits (73), Expect = 0.64
Identities = 21/91 (23%), Positives = 52/91 (57%), Gaps = 4/91 (4%)
Query: 296 KQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKD 355
K + + + NI+ + K + ++++ MA + LS E+E ++ +++ + IFA +++
Sbjct: 352 KDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLS-VDESEAFLSNLVVNKTIFAKVDRLA 410
Query: 356 GMVSFHDNPEKYNNPAMLHNIDQEMLKCIEL 386
G+++F P+ NN +L++ Q++ + L
Sbjct: 411 GIINF-QRPKDPNN--LLNDWSQKLNSLMSL 438
>gi|28872765 proteasome 26S non-ATPase subunit 12 isoform 2 [Homo
sapiens]
Length = 436
Score = 32.7 bits (73), Expect = 0.64
Identities = 21/91 (23%), Positives = 52/91 (57%), Gaps = 4/91 (4%)
Query: 296 KQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKD 355
K + + + NI+ + K + ++++ MA + LS E+E ++ +++ + IFA +++
Sbjct: 332 KDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLS-VDESEAFLSNLVVNKTIFAKVDRLA 390
Query: 356 GMVSFHDNPEKYNNPAMLHNIDQEMLKCIEL 386
G+++F P+ NN +L++ Q++ + L
Sbjct: 391 GIINF-QRPKDPNN--LLNDWSQKLNSLMSL 418
>gi|38373690 COP9 signalosome subunit 4 [Homo sapiens]
Length = 406
Score = 31.6 bits (70), Expect = 1.4
Identities = 21/98 (21%), Positives = 48/98 (48%), Gaps = 5/98 (5%)
Query: 263 LAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDM 322
L ++ N E ++ H + T D + L + ++ + N+ +K + ++ +++
Sbjct: 269 LDRIIRGNQLQEFAAMLMPHQKATTADGSSILDR----AVIEHNLLSASKLYNNITFEEL 324
Query: 323 ASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSF 360
+ +++ + AEK MI +G + I+Q DG+V F
Sbjct: 325 GALLEIPAAK-AEKIASQMITEGRMNGFIDQIDGIVHF 361
>gi|205277441 serine (or cysteine) proteinase inhibitor, clade A,
member 7 [Homo sapiens]
Length = 415
Score = 31.2 bits (69), Expect = 1.9
Identities = 21/93 (22%), Positives = 44/93 (47%), Gaps = 12/93 (12%)
Query: 211 TPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYST- 269
TP + + H ++++ SL K +L + +G+ +KPL+ +++ +Y T
Sbjct: 103 TPMVEIQHGF-----QHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETE 157
Query: 270 ------NNPSELRNLVNKHSETFTRDNNMGLVK 296
+N S + +N H E T+ +GL++
Sbjct: 158 VFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQ 190
>gi|4503521 eukaryotic translation initiation factor 3, subunit 6
48kDa [Homo sapiens]
Length = 445
Score = 30.8 bits (68), Expect = 2.4
Identities = 23/100 (23%), Positives = 48/100 (48%), Gaps = 7/100 (7%)
Query: 317 LSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNI 376
+S+ +A ++ ++ P+EAE++++++I + + A I+ K G V NN +
Sbjct: 351 ISINMLADKLNMT-PEEAERWIVNLIRNARLDAKIDSKLGHVVMG------NNAVSPYQQ 403
Query: 377 DQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSG 416
E K + ++ AM+ E +N ++ DSG
Sbjct: 404 VIEKTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQDSG 443
>gi|239751459 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
sapiens]
Length = 4485
Score = 30.4 bits (67), Expect = 3.2
Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 6/122 (4%)
Query: 2 ASALEQFVNSVRQLSAQGQ--MTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVL 59
+ AL + V+ L+ Q Q + E + E K + +L+ ++G + + + +
Sbjct: 675 SKALVAVLREVKYLNFQQQKEIPDSAESLFSENETFRKFVGNLELIVGWYNEIKTIVKAV 734
Query: 60 AVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLR 119
L +K + ++ D + L ++ LF NGE + + H L N + + KQ +
Sbjct: 735 EFLLIKSELEAI-DVKLLSAETTLF---WNGEGVFQYIQEVREILHNLQNRMQKAKQNIE 790
Query: 120 GI 121
GI
Sbjct: 791 GI 792
>gi|239745966 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
sapiens]
Length = 4485
Score = 30.4 bits (67), Expect = 3.2
Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 6/122 (4%)
Query: 2 ASALEQFVNSVRQLSAQGQ--MTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVL 59
+ AL + V+ L+ Q Q + E + E K + +L+ ++G + + + +
Sbjct: 675 SKALVAVLREVKYLNFQQQKEIPDSAESLFSENETFRKFVGNLELIVGWYNEIKTIVKAV 734
Query: 60 AVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLR 119
L +K + ++ D + L ++ LF NGE + + H L N + + KQ +
Sbjct: 735 EFLLIKSELEAI-DVKLLSAETTLF---WNGEGVFQYIQEVREILHNLQNRMQKAKQNIE 790
Query: 120 GI 121
GI
Sbjct: 791 GI 792
>gi|23957690 component of oligomeric golgi complex 7 [Homo sapiens]
Length = 770
Score = 29.6 bits (65), Expect = 5.4
Identities = 38/166 (22%), Positives = 66/166 (39%), Gaps = 10/166 (6%)
Query: 252 FIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLT 311
FI+ +++A E + N P LR++ E M LVK+ + + Q +
Sbjct: 47 FIQEVNHAVEETSHQALQNMPKVLRDVEALKQEASFLKEQMILVKEDIKKFEQDTSQSMQ 106
Query: 312 KTFLTLSLQDMASRVQLSGP--QEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNN 369
+ + + + SR+QL+ QEA+K+ + E F + +D V N+
Sbjct: 107 ---VLVEIDQVKSRMQLAAESLQEADKWSTLSADIEETFKT---QDIAVISAKLTGMQNS 160
Query: 370 PAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDS 415
ML + KC+ L+ + E +PQ V D S
Sbjct: 161 LMMLVDTPDYSEKCVHLEALKNRL--EALASPQIVAAFTSQAVDQS 204
>gi|21361787 tetratricopeptide repeat domain 17 [Homo sapiens]
Length = 1141
Score = 29.3 bits (64), Expect = 7.1
Identities = 11/32 (34%), Positives = 19/32 (59%)
Query: 178 AKHFLCYYYYGGMIYTGLKNFERALYFYEQAI 209
A HF ++ G +Y ++ FE+AL +YE +
Sbjct: 1081 APHFAVNHFTLGNVYVAMEEFEKALVWYESTL 1112
>gi|239754279 PREDICTED: hypothetical protein XP_002345940 [Homo
sapiens]
Length = 240
Score = 28.9 bits (63), Expect = 9.2
Identities = 25/74 (33%), Positives = 38/74 (51%), Gaps = 9/74 (12%)
Query: 256 LSNAYHELAQVY--STNNP-SELRNLVNKH---SETFTRDNNMGLVKQCLSSLYKKNIQR 309
+S Y+EL Q+Y TNNP ++ +N+H + +T +M K+C SSL +Q
Sbjct: 15 ISRIYNELKQIYKKKTNNPINKWAKDMNRHFSKEDIYTAKRHM---KKCSSSLAIGEMQI 71
Query: 310 LTKTFLTLSLQDMA 323
T L+L MA
Sbjct: 72 KTTMRFHLTLVRMA 85
>gi|239748812 PREDICTED: hypothetical protein XP_002346807 [Homo
sapiens]
Length = 240
Score = 28.9 bits (63), Expect = 9.2
Identities = 25/74 (33%), Positives = 38/74 (51%), Gaps = 9/74 (12%)
Query: 256 LSNAYHELAQVY--STNNP-SELRNLVNKH---SETFTRDNNMGLVKQCLSSLYKKNIQR 309
+S Y+EL Q+Y TNNP ++ +N+H + +T +M K+C SSL +Q
Sbjct: 15 ISRIYNELKQIYKKKTNNPINKWAKDMNRHFSKEDIYTAKRHM---KKCSSSLAIGEMQI 71
Query: 310 LTKTFLTLSLQDMA 323
T L+L MA
Sbjct: 72 KTTMRFHLTLVRMA 85
>gi|239740912 PREDICTED: hypothetical protein XP_002344084 [Homo
sapiens]
Length = 240
Score = 28.9 bits (63), Expect = 9.2
Identities = 25/74 (33%), Positives = 38/74 (51%), Gaps = 9/74 (12%)
Query: 256 LSNAYHELAQVY--STNNP-SELRNLVNKH---SETFTRDNNMGLVKQCLSSLYKKNIQR 309
+S Y+EL Q+Y TNNP ++ +N+H + +T +M K+C SSL +Q
Sbjct: 15 ISRIYNELKQIYKKKTNNPINKWAKDMNRHFSKEDIYTAKRHM---KKCSSSLAIGEMQI 71
Query: 310 LTKTFLTLSLQDMA 323
T L+L MA
Sbjct: 72 KTTMRFHLTLVRMA 85
>gi|239740849 PREDICTED: hypothetical protein XP_002344051 [Homo
sapiens]
Length = 240
Score = 28.9 bits (63), Expect = 9.2
Identities = 25/74 (33%), Positives = 38/74 (51%), Gaps = 9/74 (12%)
Query: 256 LSNAYHELAQVY--STNNP-SELRNLVNKH---SETFTRDNNMGLVKQCLSSLYKKNIQR 309
+S Y+EL Q+Y TNNP ++ +N+H + +T +M K+C SSL +Q
Sbjct: 15 ISRIYNELKQIYKKKTNNPINKWAKDMNRHFSKEDIYTAKRHM---KKCSSSLAIGEMQI 71
Query: 310 LTKTFLTLSLQDMA 323
T L+L MA
Sbjct: 72 KTTMRFHLTLVRMA 85
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,731,019
Number of Sequences: 37866
Number of extensions: 611050
Number of successful extensions: 1446
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1438
Number of HSP's gapped (non-prelim): 20
length of query: 423
length of database: 18,247,518
effective HSP length: 105
effective length of query: 318
effective length of database: 14,271,588
effective search space: 4538364984
effective search space used: 4538364984
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.