Search of human proteins with 11545731

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11545731 gigaxonin [Homo sapiens]
         (597 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11545731 gigaxonin [Homo sapiens]                                 1221   0.0  
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]            241   1e-63
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]            241   1e-63
gi|166235129 kelch-like 3 [Homo sapiens]                              227   3e-59
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]                     223   5e-58
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]                     223   5e-58
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]              221   2e-57
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]                     218   1e-56
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]            216   5e-56
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]                     216   5e-56
gi|14780904 kelch-like 1 protein [Homo sapiens]                       214   1e-55
gi|38194229 kelch-like 17 [Homo sapiens]                              211   2e-54
gi|11056006 kelch-like 12 [Homo sapiens]                              208   1e-53
gi|40807500 kelch-like 20 [Homo sapiens]                              207   2e-53
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]                     206   4e-53
gi|55925604 kelch-like 18 [Homo sapiens]                              206   4e-53
gi|5174473 intracisternal A particle-promoted polypeptide isofor...   198   1e-50
gi|223890235 intracisternal A particle-promoted polypeptide isof...   198   1e-50
gi|148664209 kelch-like 10 [Homo sapiens]                             195   9e-50
gi|40018614 DRE1 protein [Homo sapiens]                               195   1e-49
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo...   187   2e-47
gi|24308181 kelch-like 9 [Homo sapiens]                               187   3e-47
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]        182   8e-46
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]        182   8e-46
gi|45643138 kelch-like 13 [Homo sapiens]                              182   1e-45
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]               176   7e-44
gi|8922854 kelch-like 26 [Homo sapiens]                               174   2e-43
gi|34101268 kelch-like 8 [Homo sapiens]                               174   3e-43
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]                    172   6e-43
gi|109150407 kelch-like 6 [Homo sapiens]                              171   2e-42

>gi|11545731 gigaxonin [Homo sapiens]
          Length = 597

 Score = 1221 bits (3160), Expect = 0.0
 Identities = 597/597 (100%), Positives = 597/597 (100%)

Query: 1   MAEGSAVSDPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLN 60
           MAEGSAVSDPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLN
Sbjct: 1   MAEGSAVSDPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLN 60

Query: 61  YNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTL 120
           YNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTL
Sbjct: 61  YNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTL 120

Query: 121 CCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKE 180
           CCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKE
Sbjct: 121 CCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKE 180

Query: 181 VISLEKLNVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPL 240
           VISLEKLNVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPL
Sbjct: 181 VISLEKLNVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPL 240

Query: 241 VREIVKECSNIPLSQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYD 300
           VREIVKECSNIPLSQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYD
Sbjct: 241 VREIVKECSNIPLSQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYD 300

Query: 301 PNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPM 360
           PNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPM
Sbjct: 301 PNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPM 360

Query: 361 NEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMK 420
           NEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMK
Sbjct: 361 NEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMK 420

Query: 421 KKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSRE 480
           KKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSRE
Sbjct: 421 KKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSRE 480

Query: 481 DAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTN 540
           DAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTN
Sbjct: 481 DAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTN 540

Query: 541 YDYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRIANCKLFRLQLQQGLFRIRVHSP 597
           YDYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRIANCKLFRLQLQQGLFRIRVHSP
Sbjct: 541 YDYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRIANCKLFRLQLQQGLFRIRVHSP 597


>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
          Length = 597

 Score =  241 bits (615), Expect = 1e-63
 Identities = 157/560 (28%), Positives = 268/560 (47%), Gaps = 38/560 (6%)

Query: 9   DPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDG 68
           +P H  +  + ++  R ++  CD  +V +  EI   + +LAA SPY      +     + 
Sbjct: 39  NPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAM--FTGEMSES 96

Query: 69  STYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGC 128
              ++ ++ +    +R ++DY+++ +I++ E+ +Q ++ AA LL L D+K  CCEFLE  
Sbjct: 97  RAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQ 156

Query: 129 IAAENCIGIRDFA-LHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKL 187
           +   NC+GIR FA +H C   ++  A  Y E HF DV  +EEFL L  +++  +IS +KL
Sbjct: 157 LHPVNCLGIRAFADMHACTDLLN-KANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKL 215

Query: 188 NVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKE 247
            + +E  VFEAVI W+ HD ++R+  M  +M  + +  L   YL +++  E LV+     
Sbjct: 216 TISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKN-SSA 274

Query: 248 CSNIPLSQ------PQQGEAMLANFK-----PRGYSECIVTVGGEERVSRKPTAAMRCMC 296
           C +  +        P +   ++ + +     P    + +V VGG+   + K   ++ C  
Sbjct: 275 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQ---APKAIRSVEC-- 329

Query: 297 PLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTA 356
             YD   + W ++A L   R   G++   G +F  GG + + + + + + YDP  + WT+
Sbjct: 330 --YDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLR-VRTVDSYDPVKDQWTS 386

Query: 357 LPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCY 416
           +  M + R   G   ++G+LY +GG DG   L S+E Y+I S  W     +   R     
Sbjct: 387 VANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGV 446

Query: 417 AAMKKKIYAMGG--GSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFG 474
             +   +YA+GG  G+  +   +VECY+  T +WT I  +  RR GA    +   LY  G
Sbjct: 447 GVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVG 506

Query: 475 GVRSREDAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGD 534
           G           +V    E Y      W  + D N+C   +     G   +   +YV+G 
Sbjct: 507 G-------HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNA-----GVCAVNGLLYVVGG 554

Query: 535 LDTGTNYDYVREFKRSTGTW 554
            D   N   V  +  +T  W
Sbjct: 555 DDGSCNLASVEYYNPTTDKW 574



 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 49/154 (31%), Positives = 77/154 (50%), Gaps = 1/154 (0%)

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQD-ENKQTLSSGEKYDPDANTWTAL 357
           Y+     W  +AP++  R + GV    G L+  GG D  ++Q LS+ E Y+   N WT +
Sbjct: 424 YNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYI 483

Query: 358 PPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYA 417
             M+  R   G+  ++ +LY +GG DG     S+E YD  +  W +  D+ M R+     
Sbjct: 484 AEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVC 543

Query: 418 AMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAI 451
           A+   +Y +GG        SVE Y+P T +WT +
Sbjct: 544 AVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVV 577


>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
          Length = 593

 Score =  241 bits (615), Expect = 1e-63
 Identities = 157/560 (28%), Positives = 268/560 (47%), Gaps = 38/560 (6%)

Query: 9   DPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDG 68
           +P H  +  + ++  R ++  CD  +V +  EI   + +LAA SPY      +     + 
Sbjct: 35  NPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAM--FTGEMSES 92

Query: 69  STYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGC 128
              ++ ++ +    +R ++DY+++ +I++ E+ +Q ++ AA LL L D+K  CCEFLE  
Sbjct: 93  RAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQ 152

Query: 129 IAAENCIGIRDFA-LHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKL 187
           +   NC+GIR FA +H C   ++  A  Y E HF DV  +EEFL L  +++  +IS +KL
Sbjct: 153 LHPVNCLGIRAFADMHACTDLLN-KANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKL 211

Query: 188 NVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKE 247
            + +E  VFEAVI W+ HD ++R+  M  +M  + +  L   YL +++  E LV+     
Sbjct: 212 TISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKN-SSA 270

Query: 248 CSNIPLSQ------PQQGEAMLANFK-----PRGYSECIVTVGGEERVSRKPTAAMRCMC 296
           C +  +        P +   ++ + +     P    + +V VGG+   + K   ++ C  
Sbjct: 271 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQ---APKAIRSVEC-- 325

Query: 297 PLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTA 356
             YD   + W ++A L   R   G++   G +F  GG + + + + + + YDP  + WT+
Sbjct: 326 --YDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLR-VRTVDSYDPVKDQWTS 382

Query: 357 LPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCY 416
           +  M + R   G   ++G+LY +GG DG   L S+E Y+I S  W     +   R     
Sbjct: 383 VANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGV 442

Query: 417 AAMKKKIYAMGG--GSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFG 474
             +   +YA+GG  G+  +   +VECY+  T +WT I  +  RR GA    +   LY  G
Sbjct: 443 GVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVG 502

Query: 475 GVRSREDAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGD 534
           G           +V    E Y      W  + D N+C   +     G   +   +YV+G 
Sbjct: 503 G-------HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNA-----GVCAVNGLLYVVGG 550

Query: 535 LDTGTNYDYVREFKRSTGTW 554
            D   N   V  +  +T  W
Sbjct: 551 DDGSCNLASVEYYNPTTDKW 570



 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 49/154 (31%), Positives = 77/154 (50%), Gaps = 1/154 (0%)

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQD-ENKQTLSSGEKYDPDANTWTAL 357
           Y+     W  +AP++  R + GV    G L+  GG D  ++Q LS+ E Y+   N WT +
Sbjct: 420 YNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYI 479

Query: 358 PPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYA 417
             M+  R   G+  ++ +LY +GG DG     S+E YD  +  W +  D+ M R+     
Sbjct: 480 AEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVC 539

Query: 418 AMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAI 451
           A+   +Y +GG        SVE Y+P T +WT +
Sbjct: 540 AVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVV 573


>gi|166235129 kelch-like 3 [Homo sapiens]
          Length = 587

 Score =  227 bits (578), Expect = 3e-59
 Identities = 159/571 (27%), Positives = 266/571 (46%), Gaps = 42/571 (7%)

Query: 9   DPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDG 68
           +P H  +  + ++  R +   CD  +V +  EI   + +LAA SPY      +     + 
Sbjct: 29  NPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAM--FTGDMSES 86

Query: 69  STYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGC 128
              KIE++ +    + +++DYI++ +I + E+ +Q ++ AA LL L D++  CC+FL+  
Sbjct: 87  KAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQ 146

Query: 129 IAAENCIGIRDFA-LHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKL 187
           +   NC+GIR FA +H C   +   A  Y E HF +V   EEFL LS  ++  +IS +KL
Sbjct: 147 LHPTNCLGIRAFADVHTCTDLLQQ-ANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKL 205

Query: 188 NVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKE 247
            V +E  VFEAVI WI ++ E R  HM  +M  + +  L   YL + +  E L++     
Sbjct: 206 TVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKN-NNT 264

Query: 248 CSNIPLSQ------PQQGEAMLAN--FKPR---GYSECIVTVGGEERVSRKPTAAMRCMC 296
           C +  +        P     ++ N   KPR      + ++ VGG+   + K   ++ C  
Sbjct: 265 CKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQ---APKAIRSVEC-- 319

Query: 297 PLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTA 356
             YD     W ++A L   R   GV+   G ++  GG + + + + + + YD   + WT+
Sbjct: 320 --YDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLR-VRTVDVYDGVKDQWTS 376

Query: 357 LPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCY 416
           +  M E R   G   ++ +LY +GG DG   L S+E Y   +  W     +   R     
Sbjct: 377 IASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGV 436

Query: 417 AAMKKKIYAMGG--GSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFG 474
             ++ K+YA+GG  G+  +   +VE Y+P T +W  +  +  RR GA    ++ +LY  G
Sbjct: 437 GVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATG 496

Query: 475 GVRSREDAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGD 534
           G           +V    E Y      W  + D N+C   +     G   +   +YV+G 
Sbjct: 497 G-------HDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNA-----GVCAVNGLLYVVGG 544

Query: 535 LDTGTNYDYVREFKRSTGTWHHTKPLLPSDL 565
            D   N   V  +   T  W     LLP+++
Sbjct: 545 DDGSCNLASVEYYNPVTDKW----TLLPTNM 571


>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
          Length = 709

 Score =  223 bits (567), Expect = 5e-58
 Identities = 149/574 (25%), Positives = 264/574 (45%), Gaps = 32/574 (5%)

Query: 12  HAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTY 71
           HA +  + + ++    + CD  LV     IP  + +L++ S Y      +     +    
Sbjct: 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAM--FTNDVREARQE 213

Query: 72  KIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAA 131
           +I++EG+    +  ++ Y ++G++ L ED I+ ++  A LL L+ +   CC+FL   +  
Sbjct: 214 EIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHP 273

Query: 132 ENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGN 191
            NC+GIR FA       +H +A  Y   HF +V   +EF+ L   ++ ++++ + +N+ N
Sbjct: 274 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPN 333

Query: 192 ERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVRE------IV 245
           E  +  A++ W+ HD E R+  +  +++ + +  L   +L + M N  L R+      ++
Sbjct: 334 EETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLI 392

Query: 246 KECSNIPLSQPQQGEAMLANFKPRGYSE-CIVTVGGEERVSRKPTAAMRCMCPLYDPNRQ 304
            E     L   ++        KPR  +   +  VGG +  S K   ++      YD    
Sbjct: 393 MEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMD--STKGATSIE----KYDLRTN 446

Query: 305 LWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEAR 364
           +W  +A ++  R+  GV   +  L+V GG+D  K TL++ E Y+P   TW+ +PPM+  R
Sbjct: 447 MWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK-TLNTVECYNPKTKTWSVMPPMSTHR 505

Query: 365 HNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIY 424
           H  G+  ++G +Y +GG DG   L ++E +D  ++ W     ++  R     A +  K+Y
Sbjct: 506 HGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLY 565

Query: 425 AMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDAQG 484
           A+GG       +SVEC+DP T +WT    + +RR G         LY  GG     DA  
Sbjct: 566 AVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG----HDAPA 621

Query: 485 SEMVTCKS---EFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNY 541
           S + +  S   E Y  +   W  +   ++     S    G   +G  +Y +G  D     
Sbjct: 622 SNLTSRLSDCVERYDPKTDMWTAVASMSI-----SRDAVGVCLLGDKLYAVGGYDGQAYL 676

Query: 542 DYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRI 575
           + V  +   T  W    PL    L R G   + +
Sbjct: 677 NTVEAYDPQTNEWTQVAPLC---LGRAGACVVTV 707



 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 58/178 (32%), Positives = 87/178 (48%), Gaps = 9/178 (5%)

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALP 358
           +DP  + W  +A +S PR   GV    G L+  GG+D     L S E +DP  N WT   
Sbjct: 535 WDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD-GSSCLKSVECFDPHTNKWTLCA 593

Query: 359 PMNEARHNFGIVEIDGMLYILGGEDGEKELIS------MECYDIYSKTWTKQPDLTMVRK 412
            M++ R   G+   +G+LY +GG D     ++      +E YD  +  WT    +++ R 
Sbjct: 594 QMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRD 653

Query: 413 IGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMEL 470
                 +  K+YA+GG        +VE YDP+T +WT + PL   R G  AC V ++L
Sbjct: 654 AVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAG--ACVVTVKL 709


>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
          Length = 755

 Score =  223 bits (567), Expect = 5e-58
 Identities = 149/574 (25%), Positives = 264/574 (45%), Gaps = 32/574 (5%)

Query: 12  HAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTY 71
           HA +  + + ++    + CD  LV     IP  + +L++ S Y      +     +    
Sbjct: 202 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAM--FTNDVREARQE 259

Query: 72  KIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAA 131
           +I++EG+    +  ++ Y ++G++ L ED I+ ++  A LL L+ +   CC+FL   +  
Sbjct: 260 EIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHP 319

Query: 132 ENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGN 191
            NC+GIR FA       +H +A  Y   HF +V   +EF+ L   ++ ++++ + +N+ N
Sbjct: 320 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPN 379

Query: 192 ERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVRE------IV 245
           E  +  A++ W+ HD E R+  +  +++ + +  L   +L + M N  L R+      ++
Sbjct: 380 EETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLI 438

Query: 246 KECSNIPLSQPQQGEAMLANFKPRGYSE-CIVTVGGEERVSRKPTAAMRCMCPLYDPNRQ 304
            E     L   ++        KPR  +   +  VGG +  S K   ++      YD    
Sbjct: 439 MEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMD--STKGATSIE----KYDLRTN 492

Query: 305 LWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEAR 364
           +W  +A ++  R+  GV   +  L+V GG+D  K TL++ E Y+P   TW+ +PPM+  R
Sbjct: 493 MWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK-TLNTVECYNPKTKTWSVMPPMSTHR 551

Query: 365 HNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIY 424
           H  G+  ++G +Y +GG DG   L ++E +D  ++ W     ++  R     A +  K+Y
Sbjct: 552 HGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLY 611

Query: 425 AMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDAQG 484
           A+GG       +SVEC+DP T +WT    + +RR G         LY  GG     DA  
Sbjct: 612 AVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG----HDAPA 667

Query: 485 SEMVTCKS---EFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNY 541
           S + +  S   E Y  +   W  +   ++     S    G   +G  +Y +G  D     
Sbjct: 668 SNLTSRLSDCVERYDPKTDMWTAVASMSI-----SRDAVGVCLLGDKLYAVGGYDGQAYL 722

Query: 542 DYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRI 575
           + V  +   T  W    PL    L R G   + +
Sbjct: 723 NTVEAYDPQTNEWTQVAPLC---LGRAGACVVTV 753



 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 58/178 (32%), Positives = 87/178 (48%), Gaps = 9/178 (5%)

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALP 358
           +DP  + W  +A +S PR   GV    G L+  GG+D     L S E +DP  N WT   
Sbjct: 581 WDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD-GSSCLKSVECFDPHTNKWTLCA 639

Query: 359 PMNEARHNFGIVEIDGMLYILGGEDGEKELIS------MECYDIYSKTWTKQPDLTMVRK 412
            M++ R   G+   +G+LY +GG D     ++      +E YD  +  WT    +++ R 
Sbjct: 640 QMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRD 699

Query: 413 IGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMEL 470
                 +  K+YA+GG        +VE YDP+T +WT + PL   R G  AC V ++L
Sbjct: 700 AVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAG--ACVVTVKL 755


>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
          Length = 571

 Score =  221 bits (562), Expect = 2e-57
 Identities = 163/564 (28%), Positives = 267/564 (47%), Gaps = 48/564 (8%)

Query: 12  HAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTY 71
           H+ +LL+ L+  R+    CD  L +   +I   K +LA+ SPY +     N  + + S  
Sbjct: 17  HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENS-- 74

Query: 72  KIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAA 131
           ++E + I    ++ I++Y ++G + +++DT++ ++ AA+LL +  +   CC FLE  +  
Sbjct: 75  EVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDP 134

Query: 132 ENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGN 191
            NCIGI  FA  Y    ++  AT+Y+  +F  V  TEEF EL+   L E++S + LNV  
Sbjct: 135 GNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVAT 194

Query: 192 ERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVRE--IVKECS 249
           E  VF A+  WI +D + R+ ++  +++++ +  L   +L        L+R+    K   
Sbjct: 195 EETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLL 254

Query: 250 NIPLSQPQQGEAMLAN-----FKPRGYSECIVTVGGEERVSRKPTAAMRCM--CPLYDPN 302
           N  L      E  L++      +PR   + +  VGG+       +    C+    +Y P 
Sbjct: 255 NEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGK-------SGLFACLDSVEMYFPQ 307

Query: 303 RQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDEN-------KQTLSSGEKYDPDANTWT 355
              WI LAPL++PR   G+   +  ++V GG   N       ++  +S E ++PD NTWT
Sbjct: 308 NDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWT 367

Query: 356 ALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGC 415
           +L  MNE+R   G+V + G LY LGG DG+  L S+E Y    + W     +T  R    
Sbjct: 368 SLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFA 427

Query: 416 YAAMKKKIYAMGGGSYGKL-FESVECYDPRTQQWTAICPLKERR--FGAVACGVAME-LY 471
            A +   IYA+GG  YG     SVE YDP    W  +  + ++R  FG    GV +  ++
Sbjct: 428 AAVLDGMIYAIGG--YGPAHMNSVERYDPSKDSWEMVASMADKRIHFGV---GVMLGFIF 482

Query: 472 VFGGVRSREDAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFV-YGAVPIGASIY 530
           V GG          E        Y     +W       +C P        GA  I   +Y
Sbjct: 483 VVGGHNGVSHLSSIER-------YDPHQNQW------TVCRPMKEPRTGVGAAVIDNYLY 529

Query: 531 VIGDLDTGTNYDYVREFKRSTGTW 554
           V+G     +  + V+++   + TW
Sbjct: 530 VVGGHSGSSYLNTVQKYDPISDTW 553



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 30/98 (30%), Positives = 45/98 (45%), Gaps = 7/98 (7%)

Query: 275 IVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQ 334
           I  VGG   VS   +         YDP++  W    P+  PR   G    + +L+V GG 
Sbjct: 481 IFVVGGHNGVSHLSSIER------YDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGH 534

Query: 335 DENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEI 372
             +   L++ +KYDP ++TW     M   R NFG+  +
Sbjct: 535 SGSSY-LNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571


>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
          Length = 718

 Score =  218 bits (556), Expect = 1e-56
 Identities = 147/570 (25%), Positives = 265/570 (46%), Gaps = 28/570 (4%)

Query: 12  HAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTY 71
           HA + LR + ++ +E + CD  L+     IP  + +L+A S Y       +    +    
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVL--EAKQE 221

Query: 72  KIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAA 131
           ++ +EG+    +  ++ Y ++G ++L EDTI+ ++ AA LL LT +  +C  FL   +  
Sbjct: 222 EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHP 281

Query: 132 ENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGN 191
            NC+GIR F        +  +A +Y   HF +V   +EFL L   ++ +++  + +NV +
Sbjct: 282 SNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341

Query: 192 ERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKECSNI 251
           E  +F A+++W+ HD + R+  +  ++S + +  L    L +   +     ++  EC  +
Sbjct: 342 EETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDL--ECQKL 399

Query: 252 PLSQ------PQQGEAMLA-NFKPRGYSE-CIVTVGGEERVSRKPTAAMRCMCPLYDPNR 303
            +        P++   M +   KPR  +   +  VGG + +    T         YD   
Sbjct: 400 LMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEK------YDLRT 453

Query: 304 QLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEA 363
             W+ +  ++  R+  GV   +  L+V GG+D  K TL++ E ++P    WT +PPM+  
Sbjct: 454 NSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK-TLNTVECFNPVGKIWTVMPPMSTH 512

Query: 364 RHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKI 423
           RH  G+  ++G +Y +GG DG   L ++E +D   + W     ++  R      A+  K+
Sbjct: 513 RHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKL 572

Query: 424 YAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDAQ 483
           YA+GG       +S+E +DP T +W+   P+ +RR G         LYV GG  +     
Sbjct: 573 YAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNH 632

Query: 484 GSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDY 543
            S +  C  E Y  +   W  +    L +P  +  V    P+G  +YV+G  D  T  + 
Sbjct: 633 CSRLSDC-VERYDPKGDSWSTV--APLSVPRDAVAV---CPLGDKLYVVGGYDGHTYLNT 686

Query: 544 VREFKRSTGTWHHTKPLLPSDLRRTGCAAL 573
           V  +      W   K  +P ++ R G   +
Sbjct: 687 VESYDAQRNEW---KEEVPVNIGRAGACVV 713



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 38/127 (29%), Positives = 61/127 (48%), Gaps = 5/127 (3%)

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSG-----EKYDPDANT 353
           +DP+   W   AP+S  R   GV +  GFL+V GG D       S      E+YDP  ++
Sbjct: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDS 649

Query: 354 WTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKI 413
           W+ + P++  R    +  +   LY++GG DG   L ++E YD     W ++  + + R  
Sbjct: 650 WSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAG 709

Query: 414 GCYAAMK 420
            C   +K
Sbjct: 710 ACVVVVK 716


>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
          Length = 505

 Score =  216 bits (550), Expect = 5e-56
 Identities = 143/497 (28%), Positives = 241/497 (48%), Gaps = 36/497 (7%)

Query: 72  KIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAA 131
           ++ ++ +    +R ++DY+++ +I++ E+ +Q ++ AA LL L D+K  CCEFLE  +  
Sbjct: 8   RVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 67

Query: 132 ENCIGIRDFA-LHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVG 190
            NC+GIR FA +H C   ++  A  Y E HF DV  +EEFL L  +++  +IS +KL + 
Sbjct: 68  VNCLGIRAFADMHACTDLLN-KANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTIS 126

Query: 191 NERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKECSN 250
           +E  VFEAVI W+ HD ++R+  M  +M  + +  L   YL +++  E LV+     C +
Sbjct: 127 SEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKN-SSACKD 185

Query: 251 IPLSQ------PQQGEAMLANFK-----PRGYSECIVTVGGEERVSRKPTAAMRCMCPLY 299
             +        P +   ++ + +     P    + +V VGG+   + K   ++ C    Y
Sbjct: 186 YLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQ---APKAIRSVEC----Y 238

Query: 300 DPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPP 359
           D   + W ++A L   R   G++   G +F  GG + + + + + + YDP  + WT++  
Sbjct: 239 DFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLR-VRTVDSYDPVKDQWTSVAN 297

Query: 360 MNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAM 419
           M + R   G   ++G+LY +GG DG   L S+E Y+I S  W     +   R       +
Sbjct: 298 MRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVV 357

Query: 420 KKKIYAMGG--GSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVR 477
              +YA+GG  G+  +   +VECY+  T +WT I  +  RR GA    +   LY  GG  
Sbjct: 358 GGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG-- 415

Query: 478 SREDAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDT 537
                    +V    E Y      W  + D N+C   +     G   +   +YV+G  D 
Sbjct: 416 -----HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNA-----GVCAVNGLLYVVGGDDG 465

Query: 538 GTNYDYVREFKRSTGTW 554
             N   V  +  +T  W
Sbjct: 466 SCNLASVEYYNPTTDKW 482



 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 49/154 (31%), Positives = 77/154 (50%), Gaps = 1/154 (0%)

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQD-ENKQTLSSGEKYDPDANTWTAL 357
           Y+     W  +AP++  R + GV    G L+  GG D  ++Q LS+ E Y+   N WT +
Sbjct: 332 YNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYI 391

Query: 358 PPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYA 417
             M+  R   G+  ++ +LY +GG DG     S+E YD  +  W +  D+ M R+     
Sbjct: 392 AEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVC 451

Query: 418 AMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAI 451
           A+   +Y +GG        SVE Y+P T +WT +
Sbjct: 452 AVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVV 485


>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
          Length = 720

 Score =  216 bits (550), Expect = 5e-56
 Identities = 143/551 (25%), Positives = 257/551 (46%), Gaps = 25/551 (4%)

Query: 12  HAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTY 71
           HA + LR + ++ +E + CD  L+     IP  + +L+A S Y       +    +    
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVL--EAKQE 221

Query: 72  KIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAA 131
           ++ +EG+    +  ++ Y ++G ++L EDTI+ ++ AA LL LT +  +C  FL   +  
Sbjct: 222 EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHP 281

Query: 132 ENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGN 191
            NC+GIR F        +  +A +Y   HF +V   +EFL L   ++ +++  + +NV +
Sbjct: 282 SNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341

Query: 192 ERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKECSNI 251
           E  +F A+++W+ HD + R+  +  ++S + +  L    L +   +     ++  EC  +
Sbjct: 342 EETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDL--ECQKL 399

Query: 252 PLSQ------PQQGEAMLA-NFKPRGYSE-CIVTVGGEERVSRKPTAAMRCMCPLYDPNR 303
            +        P++   M +   KPR  +   +  VGG + +    T         YD   
Sbjct: 400 LMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEK------YDLRT 453

Query: 304 QLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEA 363
             W+ +  ++  R+  GV   +  L+V GG+D  K TL++ E ++P    WT +PPM+  
Sbjct: 454 NSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK-TLNTVECFNPVGKIWTVMPPMSTH 512

Query: 364 RHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKI 423
           RH  G+  ++G +Y +GG DG   L ++E +D   + W     ++  R      A+  K+
Sbjct: 513 RHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKL 572

Query: 424 YAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDAQ 483
           YA+GG       +S+E +DP T +W+   P+ +RR G         LYV GG  +     
Sbjct: 573 YAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNH 632

Query: 484 GSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDY 543
            S +  C  E Y  +   W  +    L +P  +  V    P+G  +YV+G  D  T  + 
Sbjct: 633 CSRLSDC-VERYDPKGDSWSTV--APLSVPRDAVAV---CPLGDKLYVVGGYDGHTYLNT 686

Query: 544 VREFKRSTGTW 554
           V  +      W
Sbjct: 687 VESYDAQRNEW 697


>gi|14780904 kelch-like 1 protein [Homo sapiens]
          Length = 748

 Score =  214 bits (546), Expect = 1e-55
 Identities = 144/549 (26%), Positives = 258/549 (46%), Gaps = 21/549 (3%)

Query: 12  HAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTY 71
           HA +  R + S+ ++ + CD  L++   +IP  + +L++ S Y      +     +    
Sbjct: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAM--FTSDVCEAKQE 251

Query: 72  KIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAA 131
           +I++EGI    + +++ + ++G + L EDTI++++ AA LL L  +  +CC FL   +  
Sbjct: 252 EIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHP 311

Query: 132 ENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGN 191
            NC+GIR FA       +  +A  Y   +  +V   +EFL L  ++L ++++ + +NV +
Sbjct: 312 SNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPD 371

Query: 192 ERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQ-----MLNEPLVREIVK 246
           E  +F A++ W+ +D + R   +  +++ + +  L    L +        N+   ++++ 
Sbjct: 372 EETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLIL 431

Query: 247 ECSNIPLSQPQQGEAMLANFKPRGYSE-CIVTVGGEERVSRKPTAAMRCMCPLYDPNRQL 305
           E     L   ++        KPR  +   +  VGG +      T         YD    L
Sbjct: 432 EAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEK------YDLRTNL 485

Query: 306 WIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEARH 365
           WI+   ++  R+  GV   +  LFV GG+D  K TL++ E Y+P   TWT LPPM+  RH
Sbjct: 486 WIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLK-TLNTVECYNPKTKTWTVLPPMSTHRH 544

Query: 366 NFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYA 425
             G+  ++G +Y +GG DG   L ++E +D  S+ WT    +++ R     AA+  K+Y+
Sbjct: 545 GLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYS 604

Query: 426 MGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDAQGS 485
           +GG        S+E YDP T +W    P+ +RR G         LY  GG  +      S
Sbjct: 605 VGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCS 664

Query: 486 EMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVR 545
            ++    E Y  +   W  +    L +P  +    G   +G  +Y +G  D  T  + + 
Sbjct: 665 RLLD-YVERYDPKTDTWTMV--APLSMPRDA---VGVCLLGDRLYAVGGYDGQTYLNTME 718

Query: 546 EFKRSTGTW 554
            +   T  W
Sbjct: 719 SYDPQTNEW 727



 Score =  100 bits (248), Expect = 5e-21
 Identities = 59/169 (34%), Positives = 82/169 (48%), Gaps = 7/169 (4%)

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALP 358
           +DP  Q W  +A +S+ R   GV +  G L+  GG+D     LSS E YDP  N W    
Sbjct: 573 WDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRD-GSSCLSSMEYYDPHTNKWNMCA 631

Query: 359 PMNEARHNFGIVEIDGMLYILGGEDG------EKELISMECYDIYSKTWTKQPDLTMVRK 412
           PM + R   G+   DG LY +GG D        + L  +E YD  + TWT    L+M R 
Sbjct: 632 PMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRD 691

Query: 413 IGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGA 461
                 +  ++YA+GG        ++E YDP+T +WT +  L   R GA
Sbjct: 692 AVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGA 740



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 43/128 (33%), Positives = 64/128 (50%), Gaps = 5/128 (3%)

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDEN-----KQTLSSGEKYDPDANT 353
           YDP+   W   AP+   R   GV + +GFL+  GG D        + L   E+YDP  +T
Sbjct: 620 YDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDT 679

Query: 354 WTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKI 413
           WT + P++  R   G+  +   LY +GG DG+  L +ME YD  +  WT+   L + R  
Sbjct: 680 WTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAG 739

Query: 414 GCYAAMKK 421
            C   +K+
Sbjct: 740 ACVVVIKQ 747


>gi|38194229 kelch-like 17 [Homo sapiens]
          Length = 642

 Score =  211 bits (537), Expect = 2e-54
 Identities = 153/565 (27%), Positives = 253/565 (44%), Gaps = 36/565 (6%)

Query: 3   EGSAVS--DPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLN 60
           EG +V+    +H      A+S  R+    CD  L +  +EI   K +LA+ SPY      
Sbjct: 63  EGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFT 122

Query: 61  YNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTL 120
            N   +   T+ + L  I    + +++ + ++ +I + E  +Q ++ AA LL L  ++  
Sbjct: 123 -NEMSESRQTH-VTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDA 180

Query: 121 CCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKE 180
           CC+FL   +   NC+GIR FA  +    +   A  Y+  HF DV+ TEEF+ L  +++ E
Sbjct: 181 CCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLE 240

Query: 181 VISLEKLNVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPL 240
           ++S + LNV +E  V+ AV+ W+ HD + R+ H+  +M  + +  L   +L   +  E L
Sbjct: 241 LVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESL 300

Query: 241 VR------EIVKECSNIPLSQPQQGEAMLANFKPR---GYSECIVTVGGEERVSRKPTAA 291
           VR      +++ E     L   Q+G    +  +PR   G    +  VGG          A
Sbjct: 301 VRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGS------LFA 354

Query: 292 MRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDA 351
           +   C  YD     W  +A +S  R   GV +    L+  GG D     L++ E YDP  
Sbjct: 355 IHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYD-GTSDLATVESYDPVT 413

Query: 352 NTWTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVR 411
           NTW     M   R   G+  + G+LY  GG DG   L S E YD  + TWT    ++  R
Sbjct: 414 NTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRR 473

Query: 412 KIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELY 471
           +    A +   +YA+GG        +VE Y+P+   W+ +  +  RR  A    +   LY
Sbjct: 474 RYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALY 533

Query: 472 VFGGVRSREDAQGSEMVTCKS--EFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASI 529
           V G         G++  +C +  E Y  +   W  +   N+         +  V +   +
Sbjct: 534 VAG---------GNDGTSCLNSVERYSPKAGAWESVAPMNI-----RRSTHDLVAMDGWL 579

Query: 530 YVIGDLDTGTNYDYVREFKRSTGTW 554
           Y +G  D  ++ + + ++   T  W
Sbjct: 580 YAVGGNDGSSSLNSIEKYNPRTNKW 604



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 1/160 (0%)

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALP 358
           YDP    W  +A +S  R    V + +G L+  GG D +   L++ EKY+P  N W+ + 
Sbjct: 456 YDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSH-LATVEKYEPQVNVWSPVA 514

Query: 359 PMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAA 418
            M   R + G+  ++G LY+ GG DG   L S+E Y   +  W     + + R      A
Sbjct: 515 SMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVA 574

Query: 419 MKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERR 458
           M   +YA+GG        S+E Y+PRT +W A   +  RR
Sbjct: 575 MDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRR 614



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 24/75 (32%), Positives = 41/75 (54%), Gaps = 1/75 (1%)

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALP 358
           Y P    W  +AP+++ R  H +++ +G+L+  GG D    +L+S EKY+P  N W A  
Sbjct: 550 YSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGND-GSSSLNSIEKYNPRTNKWVAAS 608

Query: 359 PMNEARHNFGIVEID 373
            M   R + G+  ++
Sbjct: 609 CMFTRRSSVGVAVLE 623


>gi|11056006 kelch-like 12 [Homo sapiens]
          Length = 568

 Score =  208 bits (529), Expect = 1e-53
 Identities = 138/475 (29%), Positives = 234/475 (49%), Gaps = 20/475 (4%)

Query: 12  HAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTY 71
           HA  +L +++S R+ +  CD  L ++ ++ P  + +LAA S Y       +   + G  Y
Sbjct: 15  HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFT-SELSEKGKPY 73

Query: 72  KIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAA 131
            ++++G++   M  +LD++++  + +  + +Q+++ AA LL L  +K  CCEFLE  +  
Sbjct: 74  -VDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDP 132

Query: 132 ENCIGIRDFA-LHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVG 190
            NC+GIRDFA  H C+  +   A  + + HF +V   EEF+ LS  +++++I  +++ V 
Sbjct: 133 SNCLGIRDFAETHNCVDLMQ-AAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVD 191

Query: 191 NERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLV------REI 244
           +E  VFEAVI W+ H  + R+  + +++  + +  L   Y+ + +  EP +      R++
Sbjct: 192 SEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDL 251

Query: 245 VKECSNIPLSQPQQGEAMLANFKPR-GYSECIVTVGGEERVSRKPTAAMRCMCPLYDPNR 303
           V E     L    + +      + R G +E ++ VGG     + P   +      YDP  
Sbjct: 252 VDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGS-QQSPIDVVE----KYDPKT 306

Query: 304 QLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDAN---TWTALPPM 360
           Q W  L  ++  R     +S    ++V GG D  +  LSS E  D  A+    W ++ PM
Sbjct: 307 QEWSFLPSITRKRRYVASVSLHDRIYVIGGYD-GRSRLSSVECLDYTADEDGVWYSVAPM 365

Query: 361 NEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMK 420
           N  R   G   +  M+Y+ GG DG +   SME YD     W+   D+   R+        
Sbjct: 366 NVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVAS 425

Query: 421 KKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGG 475
             IY +GG     +  SVE YDP T  WT + P+  +R GA    +   +YV GG
Sbjct: 426 GVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGG 480



 Score =  106 bits (264), Expect = 7e-23
 Identities = 60/190 (31%), Positives = 91/190 (47%), Gaps = 6/190 (3%)

Query: 275 IVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQ 334
           ++ V G    SR+ T+  R     YDPN   W  L  +   R   G++ A G ++  GG 
Sbjct: 380 MIYVSGGFDGSRRHTSMER-----YDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGY 434

Query: 335 DENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECY 394
           D     L+S EKYDP    WT + PM   R   G+  ++  +Y++GG DG   L S+E Y
Sbjct: 435 D-GLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAY 493

Query: 395 DIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPL 454
           +I + +WT    +T  R       ++ ++YA+ G     L  S+ECYDP    W  +  +
Sbjct: 494 NIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSM 553

Query: 455 KERRFGAVAC 464
             +R  A  C
Sbjct: 554 GTQRCDAGVC 563



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 31/128 (24%), Positives = 52/128 (40%), Gaps = 9/128 (7%)

Query: 427 GGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDAQGSE 486
           G GS     + VE YDP+TQ+W+ +  +  +R    +  +   +YV GG   R      E
Sbjct: 288 GFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVE 347

Query: 487 MVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVRE 546
            +    ++  DE   W  +   N+        + GA  +G  IYV G  D    +  +  
Sbjct: 348 CL----DYTADEDGVWYSVAPMNV-----RRGLAGATTLGDMIYVSGGFDGSRRHTSMER 398

Query: 547 FKRSTGTW 554
           +  +   W
Sbjct: 399 YDPNIDQW 406


>gi|40807500 kelch-like 20 [Homo sapiens]
          Length = 609

 Score =  207 bits (528), Expect = 2e-53
 Identities = 150/559 (26%), Positives = 261/559 (46%), Gaps = 34/559 (6%)

Query: 7   VSDPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKD 66
           +SD +H  + L  ++  R+    CD  LV+  ++I   + IL+A SPY R    +     
Sbjct: 46  ISD-KHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAM--FTGELA 102

Query: 67  DGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 126
           +    ++ +  I    M  ++D+ ++ QI + E  +Q ++ AA LL L +++  CCEFL+
Sbjct: 103 ESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLK 162

Query: 127 GCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEK 186
             +   NC+GIR FA  +    +  +A ++ + +F++V  +EEF+ L   +L ++IS ++
Sbjct: 163 RQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDE 222

Query: 187 LNVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLV----- 241
           LNV +E  VF AV+ W+ +  + R+  +  V+  + +  L   +L   + ++PL+     
Sbjct: 223 LNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEE 282

Query: 242 -REIVKECSN---IPLSQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCP 297
            R++V E  N   +P  +P          KP    E +  VGG    S    +++     
Sbjct: 283 CRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGG--WCSGDAISSVE---- 336

Query: 298 LYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTA- 356
            YDP    W  +A +S  R   GV   +  L+  GG D     L+S E+YDP  N W++ 
Sbjct: 337 RYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHD-GSSYLNSVERYDPKTNQWSSD 395

Query: 357 LPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCY 416
           + P +  R + G+  + G LY +GG+DG   L  +E YD     WT+   ++  R     
Sbjct: 396 VAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAV 455

Query: 417 AAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAME-LYVFGG 475
           A +   +YA+GG        +VE Y+P+  +W  I P+  RR   + C V  + +Y  GG
Sbjct: 456 AVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRR-KHLGCAVYQDMIYAVGG 514

Query: 476 VRSREDAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDL 535
              R+D   +E+    +E Y+    +W       +    S     G   +   +  +G  
Sbjct: 515 ---RDDT--TEL--SSAERYNPRTNQW-----SPVVAMTSRRSGVGLAVVNGQLMAVGGF 562

Query: 536 DTGTNYDYVREFKRSTGTW 554
           D  T    +  F     TW
Sbjct: 563 DGTTYLKTIEVFDPDANTW 581



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 66/241 (27%), Positives = 101/241 (41%), Gaps = 20/241 (8%)

Query: 223 VSGLD-SSYLREQMLNEPLVREIVKECSNIPLSQPQQGEAMLANFKPRGYSECIVTVGGE 281
           V G D SSYL      +P   +   + +     +   G A+L  F        +  VGG+
Sbjct: 370 VGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGF--------LYAVGGQ 421

Query: 282 ERVSRKPTAAMRCM--CPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQ 339
           + VS        C+     YDP    W  +A +S  R+   V    GFL+  GG D    
Sbjct: 422 DGVS--------CLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSD-GTS 472

Query: 340 TLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSK 399
            L++ E+Y+P  N W  + PM   R + G      M+Y +GG D   EL S E Y+  + 
Sbjct: 473 PLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTN 532

Query: 400 TWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRF 459
            W+    +T  R     A +  ++ A+GG       +++E +DP    W     +  RR 
Sbjct: 533 QWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRL 592

Query: 460 G 460
           G
Sbjct: 593 G 593



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 7/99 (7%)

Query: 271 YSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFV 330
           Y + I  VGG +  +   +A        Y+P    W  +  ++  R   G+    G L  
Sbjct: 505 YQDMIYAVGGRDDTTELSSAER------YNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMA 558

Query: 331 FGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNFGI 369
            GG D     L + E +DPDANTW     MN  R   G+
Sbjct: 559 VGGFDGTTY-LKTIEVFDPDANTWRLYGGMNYRRLGGGV 596


>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
          Length = 694

 Score =  206 bits (525), Expect = 4e-53
 Identities = 138/514 (26%), Positives = 241/514 (46%), Gaps = 30/514 (5%)

Query: 72  KIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAA 131
           +I++EG+    +  ++ Y ++G++ L ED I+ ++  A LL L+ +   CC+FL   +  
Sbjct: 199 EIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHP 258

Query: 132 ENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGN 191
            NC+GIR FA       +H +A  Y   HF +V   +EF+ L   ++ ++++ + +N+ N
Sbjct: 259 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPN 318

Query: 192 ERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVRE------IV 245
           E  +  A++ W+ HD E R+  +  +++ + +  L   +L + M N  L R+      ++
Sbjct: 319 EETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLI 377

Query: 246 KECSNIPLSQPQQGEAMLANFKPRGYSE-CIVTVGGEERVSRKPTAAMRCMCPLYDPNRQ 304
            E     L   ++        KPR  +   +  VGG +  S K   ++      YD    
Sbjct: 378 MEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMD--STKGATSIE----KYDLRTN 431

Query: 305 LWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEAR 364
           +W  +A ++  R+  GV   +  L+V GG+D  K TL++ E Y+P   TW+ +PPM+  R
Sbjct: 432 MWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK-TLNTVECYNPKTKTWSVMPPMSTHR 490

Query: 365 HNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIY 424
           H  G+  ++G +Y +GG DG   L ++E +D  ++ W     ++  R     A +  K+Y
Sbjct: 491 HGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLY 550

Query: 425 AMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDAQG 484
           A+GG       +SVEC+DP T +WT    + +RR G         LY  GG     DA  
Sbjct: 551 AVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG----HDAPA 606

Query: 485 SEMVTCKS---EFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNY 541
           S + +  S   E Y  +   W  +   ++     S    G   +G  +Y +G  D     
Sbjct: 607 SNLTSRLSDCVERYDPKTDMWTAVASMSI-----SRDAVGVCLLGDKLYAVGGYDGQAYL 661

Query: 542 DYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRI 575
           + V  +   T  W    PL    L R G   + +
Sbjct: 662 NTVEAYDPQTNEWTQVAPLC---LGRAGACVVTV 692



 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 58/178 (32%), Positives = 87/178 (48%), Gaps = 9/178 (5%)

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALP 358
           +DP  + W  +A +S PR   GV    G L+  GG+D     L S E +DP  N WT   
Sbjct: 520 WDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD-GSSCLKSVECFDPHTNKWTLCA 578

Query: 359 PMNEARHNFGIVEIDGMLYILGGEDGEKELIS------MECYDIYSKTWTKQPDLTMVRK 412
            M++ R   G+   +G+LY +GG D     ++      +E YD  +  WT    +++ R 
Sbjct: 579 QMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRD 638

Query: 413 IGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMEL 470
                 +  K+YA+GG        +VE YDP+T +WT + PL   R G  AC V ++L
Sbjct: 639 AVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAG--ACVVTVKL 694


>gi|55925604 kelch-like 18 [Homo sapiens]
          Length = 574

 Score =  206 bits (525), Expect = 4e-53
 Identities = 139/555 (25%), Positives = 246/555 (44%), Gaps = 39/555 (7%)

Query: 20  LSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPP--KDDGSTYKIELEG 77
           +   R + + CD  L +   +    + +LAA+ PY       +    K D    +I ++G
Sbjct: 28  MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQD----EIVMQG 83

Query: 78  ISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGI 137
           +    +  ++++ ++G + +++  +Q ++  A  L L  +K  CC FL   +  +NC+G+
Sbjct: 84  MDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGV 143

Query: 138 RDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFE 197
           R FA       ++  A  ++  HF +VS +EEFL L  + + E++S ++LNV +E  VFE
Sbjct: 144 RQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFE 203

Query: 198 AVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLV------REIVKECSNI 251
           A + W+ +D E R  ++ +++S + +      +L +++  + LV      R++V E  + 
Sbjct: 204 AALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDY 263

Query: 252 PLSQPQQGEAMLANFKPR---GYSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIE 308
            L   ++        +PR     +  I  VGG              +  ++DP    W  
Sbjct: 264 HLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLN-----VVEVFDPIANCWER 318

Query: 309 LAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNFG 368
             P++  R   GV    G L+  GG D  +  LS+ E Y+P+ +TWT +  MN  R   G
Sbjct: 319 CRPMTTARSRVGVAVVNGLLYAIGGYD-GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMG 377

Query: 369 IVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGG 428
            V +DG +Y+ GG DG   L S+E Y   +  WT    ++  R        + +IY  GG
Sbjct: 378 TVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGG 437

Query: 429 GSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDAQGSEMV 488
               ++F SVE Y+  T  W     +  +R    A  +  +++V GG     D  G   +
Sbjct: 438 HDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY----DGSGFLSI 493

Query: 489 TCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGAS---IYVIGDLDTGTNYDYVR 545
              +E Y     +W        C+          V + AS   +Y +G  D  +N   V 
Sbjct: 494 ---AEMYSSVADQW--------CLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVE 542

Query: 546 EFKRSTGTWHHTKPL 560
            +   T  W    P+
Sbjct: 543 MYDPETDCWTFMAPM 557



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 48/203 (23%), Positives = 79/203 (38%), Gaps = 14/203 (6%)

Query: 372 IDGMLYILGGEDGEKELISM-ECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGS 430
           I G++Y +GG +   + +++ E +D  +  W +   +T  R     A +   +YA+GG  
Sbjct: 286 IAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYD 345

Query: 431 YGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDAQGSEMVTC 490
                 +VE Y+P T  WT +  +  +R       +  ++YV GG          E    
Sbjct: 346 GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVET--- 402

Query: 491 KSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVREFKRS 550
               Y  E  +W  +   +     S+    G       IYV G  D    +  V  +   
Sbjct: 403 ----YSPETDKWTVVTSMS-----SNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHH 453

Query: 551 TGTWHHTKPLLPSDLRRTGCAAL 573
           T TWH    +L    R  G A+L
Sbjct: 454 TATWHPAAGMLNKRCRH-GAASL 475


>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
           [Homo sapiens]
          Length = 584

 Score =  198 bits (503), Expect = 1e-50
 Identities = 145/544 (26%), Positives = 244/544 (44%), Gaps = 70/544 (12%)

Query: 2   AEGSAVSDPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNY 61
           A  S  S  +HA  +L  ++  R    FCD  L +  E     + +LAA+SPY      +
Sbjct: 9   AADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAAL--F 66

Query: 62  NPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLC 121
                + S   + + GI   + + +LD+I++G + +  + +Q+++ AAD+L LT++  LC
Sbjct: 67  TGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLC 126

Query: 122 CEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEV 181
           CEFL+G I   NCIGI  F+     H +   +  Y+  HF +V S EEFL L+  +L ++
Sbjct: 127 CEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKI 186

Query: 182 ISLEKLNVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSAL------------WVSGLDSS 229
           +  E+L++ +E  VF A ++WI  D   R+ H+ +V+  +            ++ G+   
Sbjct: 187 LRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDF 246

Query: 230 YLREQMLNEPLVREIVKECSNIPLSQPQQGEAMLANFKPRGYS-ECIVTVGGEERVSR-- 286
            LR  +  + L++E  + C + P           +  +PR  + + +  VGG  R+    
Sbjct: 247 NLRVAL--QTLLKEYCEVCKS-PKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGR 303

Query: 287 -KPTAAMRCM----------------------------------------------CPLY 299
              + A+ C+                                                 Y
Sbjct: 304 WSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECY 363

Query: 300 DPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPP 359
           DP  + W  +A ++ PR   GV    G ++  GG     +  ++ E++DPD N W  +  
Sbjct: 364 DPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGW-VGAEIGNTIERFDPDENKWEVVGN 422

Query: 360 MNEARHNFGIVEIDGMLYILGGEDGEK-ELISMECYDIYSKTWTKQPDLTMVRKIGCYAA 418
           M  +R+ FG  E+ G++Y++GG   E  EL S E YD  SK W+  P +   R     AA
Sbjct: 423 MAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAA 482

Query: 419 MKKKIYAMGGGSYGK-LFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVR 477
           +   IY++GG +  +    +VE Y    ++W  +  +K  R G     V   LYV GG  
Sbjct: 483 LNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRS 542

Query: 478 SRED 481
           S  D
Sbjct: 543 SSHD 546



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 45/160 (28%), Positives = 74/160 (46%), Gaps = 7/160 (4%)

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALP 358
           +DP+   W  +  +++ R   G    +G ++V GG       L S E YDP +  W+ LP
Sbjct: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLP 469

Query: 359 PMNEARHNFGIVEIDGMLYILGG-EDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYA 417
           PM   R   G+  ++  +Y +GG  + +  L ++E Y    + W +   + + R   C  
Sbjct: 470 PMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVV 529

Query: 418 AMKKKIYAMGGGSYGKLF------ESVECYDPRTQQWTAI 451
           A+   +Y  GG S    F      +SVE Y+P +  WT I
Sbjct: 530 AVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEI 569



 Score = 63.2 bits (152), Expect = 7e-10
 Identities = 35/128 (27%), Positives = 60/128 (46%), Gaps = 6/128 (4%)

Query: 298 LYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTAL 357
           +YDP  + W  L P+   R   GV +    ++  GG +E +  L + EKY  +   W  +
Sbjct: 457 VYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEV 516

Query: 358 PPMNEARHNFGIVEIDGMLYILGGEDGEKELI------SMECYDIYSKTWTKQPDLTMVR 411
             M   R    +V ++G+LY+ GG     + +      S+E Y+ +S TWT+  ++   R
Sbjct: 517 ASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSR 576

Query: 412 KIGCYAAM 419
             G  A +
Sbjct: 577 CEGGVAVL 584



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 29/103 (28%), Positives = 49/103 (47%), Gaps = 10/103 (9%)

Query: 272 SECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVF 331
           ++CI +VGG            +     Y    + W+E+A + +PR    V++  G L+V 
Sbjct: 484 NDCIYSVGGWNETQDALHTVEK-----YSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVS 538

Query: 332 GGQDENKQ-----TLSSGEKYDPDANTWTALPPMNEARHNFGI 369
           GG+  +       TL S E Y+P ++TWT +  M  +R   G+
Sbjct: 539 GGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGV 581


>gi|223890235 intracisternal A particle-promoted polypeptide isoform
           2 [Homo sapiens]
          Length = 582

 Score =  198 bits (503), Expect = 1e-50
 Identities = 145/544 (26%), Positives = 244/544 (44%), Gaps = 70/544 (12%)

Query: 2   AEGSAVSDPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNY 61
           A  S  S  +HA  +L  ++  R    FCD  L +  E     + +LAA+SPY      +
Sbjct: 9   AADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAAL--F 66

Query: 62  NPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLC 121
                + S   + + GI   + + +LD+I++G + +  + +Q+++ AAD+L LT++  LC
Sbjct: 67  TGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLC 126

Query: 122 CEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEV 181
           CEFL+G I   NCIGI  F+     H +   +  Y+  HF +V S EEFL L+  +L ++
Sbjct: 127 CEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKI 186

Query: 182 ISLEKLNVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSAL------------WVSGLDSS 229
           +  E+L++ +E  VF A ++WI  D   R+ H+ +V+  +            ++ G+   
Sbjct: 187 LRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDF 246

Query: 230 YLREQMLNEPLVREIVKECSNIPLSQPQQGEAMLANFKPRGYS-ECIVTVGGEERVSR-- 286
            LR  +  + L++E  + C + P           +  +PR  + + +  VGG  R+    
Sbjct: 247 NLRVAL--QTLLKEYCEVCKS-PKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGR 303

Query: 287 -KPTAAMRCM----------------------------------------------CPLY 299
              + A+ C+                                                 Y
Sbjct: 304 WSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECY 363

Query: 300 DPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPP 359
           DP  + W  +A ++ PR   GV    G ++  GG     +  ++ E++DPD N W  +  
Sbjct: 364 DPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGW-VGAEIGNTIERFDPDENKWEVVGN 422

Query: 360 MNEARHNFGIVEIDGMLYILGGEDGEK-ELISMECYDIYSKTWTKQPDLTMVRKIGCYAA 418
           M  +R+ FG  E+ G++Y++GG   E  EL S E YD  SK W+  P +   R     AA
Sbjct: 423 MAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAA 482

Query: 419 MKKKIYAMGGGSYGK-LFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVR 477
           +   IY++GG +  +    +VE Y    ++W  +  +K  R G     V   LYV GG  
Sbjct: 483 LNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRS 542

Query: 478 SRED 481
           S  D
Sbjct: 543 SSHD 546



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 27/106 (25%), Positives = 50/106 (47%), Gaps = 2/106 (1%)

Query: 298 LYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTAL 357
           +YDP  + W  L P+   R   GV +    ++  GG +E +  L + EKY  +   W  +
Sbjct: 457 VYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEV 516

Query: 358 PPMNEARHNFGIVEIDGMLYILGGEDGEKELISMEC--YDIYSKTW 401
             M   R    +V ++G+LY+ GG     + ++ +   Y+++   W
Sbjct: 517 ASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPDTHRYEVFRLKW 562


>gi|148664209 kelch-like 10 [Homo sapiens]
          Length = 608

 Score =  195 bits (496), Expect = 9e-50
 Identities = 130/493 (26%), Positives = 229/493 (46%), Gaps = 29/493 (5%)

Query: 3   EGSAVSDPQHAARLLRALSSF--------REESRFCDAHLVLDGEEIPVQKNILAAASPY 54
           E +A S   H   + R +S+         R E + CD  + ++G E    KNIL + S Y
Sbjct: 4   ESAAASTRFHQPHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSY 63

Query: 55  IRTKLNYNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLL 114
            R          +   Y I   GIS  +M+ I++Y ++  + +  D ++ ++ AAD   +
Sbjct: 64  FRALFTSGWNNTEKKVYNIP--GISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNI 121

Query: 115 TDLKTLCCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRD-VSSTEEFLEL 173
             +   CCEFL+  +  +NCIGI  F  +Y    +   A  ++  +F + V  + EFLEL
Sbjct: 122 MGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLEL 181

Query: 174 SPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLRE 233
           S  +LK++I  ++LNV  E  VFEA+++WI+HD + RK H+  ++  + ++ + + Y   
Sbjct: 182 SVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMN 241

Query: 234 QM-LNE---------PLVREIVKECSNIPLSQPQQGEAMLANFKPRGYSECIVTVGGEER 283
            + +N+         P++   +K   ++ ++ P   +      +PR     +  +GG   
Sbjct: 242 NVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSG 301

Query: 284 VSRKPTAAMRCMCPLYDPNRQLWIELA-PLSMPRINHGVLSAEGFLFVFGGQDENKQTLS 342
            S  PT A+      YD     W+ +      PR  HG    +G++++ GG D +    +
Sbjct: 302 GS--PTNAIEA----YDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFD-SVDYFN 354

Query: 343 SGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWT 402
           S +++DP   TW  + PM+  R    +  +   +Y +GG DG   L + E Y+  +  WT
Sbjct: 355 SVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWT 414

Query: 403 KQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAV 462
               +   R       +  K+Y  GG +  +   + E Y+  + QWT I P++ RR G  
Sbjct: 415 LIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIG 474

Query: 463 ACGVAMELYVFGG 475
                  +Y  GG
Sbjct: 475 VIAYGEHVYAVGG 487



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 48/174 (27%), Positives = 79/174 (45%), Gaps = 7/174 (4%)

Query: 275 IVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQ 334
           I  +GG +   R  TA        Y+P    W  +AP+   R +    +  G +++ GG 
Sbjct: 388 IYAMGGFDGYVRLNTAER------YEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGF 441

Query: 335 DENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECY 394
           + N + L + E Y+ ++N WT + PM   R   G++     +Y +GG DG   L S E Y
Sbjct: 442 NGN-ECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAY 500

Query: 395 DIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQW 448
              + TW   P +   R       +   ++ +GG +      +VECYD +T +W
Sbjct: 501 SPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEW 554



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 38/114 (33%), Positives = 59/114 (51%), Gaps = 1/114 (0%)

Query: 298 LYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTAL 357
           +Y+     W  +AP+   R   GV++    ++  GG D     L S E Y P ANTW  +
Sbjct: 452 VYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFD-GANRLRSAEAYSPVANTWRTI 510

Query: 358 PPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVR 411
           P M   R NFGI  +D +L+++GG +G     ++ECYD  +  W    D+++ R
Sbjct: 511 PTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYR 564



 Score = 34.7 bits (78), Expect = 0.26
 Identities = 18/68 (26%), Positives = 29/68 (42%), Gaps = 4/68 (5%)

Query: 493 EFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVREFKRSTG 552
           E Y     RW+ +     C   S    +GA  +   +Y+IG  D+   ++ V+ F     
Sbjct: 309 EAYDARADRWVNVT----CEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKK 364

Query: 553 TWHHTKPL 560
           TWH   P+
Sbjct: 365 TWHQVAPM 372


>gi|40018614 DRE1 protein [Homo sapiens]
          Length = 600

 Score =  195 bits (495), Expect = 1e-49
 Identities = 134/481 (27%), Positives = 230/481 (47%), Gaps = 26/481 (5%)

Query: 8   SDPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDD 67
           S   HA  +L+  + FR+   F D  + ++G+E P  + +L+A S Y R    +     +
Sbjct: 44  SGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAM--FCNDHRE 101

Query: 68  GSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEG 127
                +E+ GI    M   L Y+++G++++  + +Q + + + L  ++ L+  C +FLE 
Sbjct: 102 SREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEE 161

Query: 128 CIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKL 187
            +   NC+GI+ FA  + L  +      +    F DVS  EEFLEL   +L + I  ++L
Sbjct: 162 QLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDEL 221

Query: 188 NVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKE 247
            +G E  VFEAV+RW+    ++R+  + ++++ + +  L  +Y  + +  + L++    E
Sbjct: 222 VIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQN-SPE 280

Query: 248 CSNIPLSQPQQ-----GEAMLANFKPR---GYSECIVTVGGEERVSRKPTAAMRCMCPLY 299
           C  + L + ++      E M    +PR   GYSE IV VGG ERV         C    Y
Sbjct: 281 CYQL-LHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTEC----Y 335

Query: 300 DPNRQLWIELAPL-SMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALP 358
           DP    W  LA L    +  + V +    + V GG+  ++        Y+   N W  + 
Sbjct: 336 DPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWI----YNSQLNIWIRVA 391

Query: 359 PMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAA 418
            +N+ R    +  + G +Y++GG DG+  L S+ECYD +S  WT+   L          +
Sbjct: 392 SLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTS 451

Query: 419 MKKKIYAMGGG-SYGKLFESVECYDPRTQQW--TAICPLKERRFGAVACGVAMELYVFGG 475
              K++ +GGG       + V+ YDP T  W   A  P+ +R   AV+      +YV GG
Sbjct: 452 CVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNL--IYVAGG 509

Query: 476 V 476
           +
Sbjct: 510 L 510



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 49/182 (26%), Positives = 81/182 (44%), Gaps = 14/182 (7%)

Query: 275 IVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQ 334
           +  VGG +  +R   +++ C    YD     W E+APL     +  V S  G LFV GG 
Sbjct: 409 VYVVGGYDGQNR--LSSVEC----YDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGG 462

Query: 335 DENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECY 394
            ++       + YDP+ N+W     +  A+     V ++ ++Y+ GG        ++ CY
Sbjct: 463 PDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTK-----AIYCY 517

Query: 395 DIYSKTWTKQPDLTMVRKIGC-YAAMKKKIYAMGGG-SYGKLFESVECYDPRTQQWTAIC 452
           D     W    + T  R+  C  +    KIY +GG    G+  +++ CYDP T   T + 
Sbjct: 518 DPVEDYWMHVQN-TFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVA 576

Query: 453 PL 454
            +
Sbjct: 577 AM 578



 Score = 33.1 bits (74), Expect = 0.75
 Identities = 22/84 (26%), Positives = 35/84 (41%), Gaps = 4/84 (4%)

Query: 289 TAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYD 348
           T A+ C    YDP    W+ +      + N G+    G +++ GG+ EN +   +   YD
Sbjct: 511 TKAIYC----YDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYD 566

Query: 349 PDANTWTALPPMNEARHNFGIVEI 372
           P  +  T +  M       G V I
Sbjct: 567 PATSIITGVAAMPRPVSYHGCVTI 590


>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
           sapiens]
          Length = 634

 Score =  187 bits (475), Expect = 2e-47
 Identities = 129/512 (25%), Positives = 239/512 (46%), Gaps = 24/512 (4%)

Query: 5   SAVSDPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPP 64
           S ++D  +   LL  LS  R+E+  CD  +    +   V K+++A+ S Y      YN  
Sbjct: 48  SELTDASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYF-----YNIL 102

Query: 65  KDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEF 124
           K D S  +++L  IS + +  ++ Y ++G++ L+  TI  ++ AA  L +  L  +C +F
Sbjct: 103 KKDPSIQRVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDF 162

Query: 125 LEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISL 184
           L   ++ ENC+ + + A  Y L +    A +++  +F + + +++F++L+ +++ E++  
Sbjct: 163 LIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLID 222

Query: 185 EKLNVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDS----SYLRE--QMLNE 238
           + L + +E   F+  ++W+  D + R  +  D++S +    + +    +Y++   +M+ +
Sbjct: 223 DDLQLPSEIVAFQIAMKWLEFDQK-RVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQD 281

Query: 239 PLVREIVKECSNIPLSQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPL 298
                ++ +  N  L    Q        + RG    +VTVGG   ++ K  +       L
Sbjct: 282 ADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDI----L 337

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDEN------KQTLSSGEKYDPDAN 352
           Y      W +L  +     N  V   +GFL+V GG+D+N      K  +S+  +YDP  N
Sbjct: 338 YRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFN 397

Query: 353 TWTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRK 412
           TW  L  MN+ R +F +   +G++Y  GG + E  L S+ECY   +  W  +  L + R 
Sbjct: 398 TWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARC 457

Query: 413 IGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYV 472
               A    ++   GG        SV  YDP +  W  +  L   R    A  ++  +YV
Sbjct: 458 CHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYV 517

Query: 473 FGGVRSREDAQGSEMVTCKSEFYHDEFKRWIY 504
            GG  S+   +G  +     E Y     +W Y
Sbjct: 518 MGG--SQLGPRGERVDVLTVECYSPATGQWSY 547



 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 52/205 (25%), Positives = 93/205 (45%), Gaps = 14/205 (6%)

Query: 271 YSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFV 330
           ++  +   GG  R +    A++ C    Y P+   W    PL + R  H    A+G + V
Sbjct: 417 FNGLVYAAGG--RNAEGSLASLEC----YVPSTNQWQPKTPLEVARCCHASAVADGRVLV 470

Query: 331 FGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGED----GEK 386
            GG   N  + S    YDP +++W  LP ++  R     V +   +Y++GG      GE+
Sbjct: 471 TGGYIANAYSRSVCA-YDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGER 529

Query: 387 -ELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYG--KLFESVECYDP 443
            +++++ECY   +  W+    L +       +A+  + Y +GG + G  K  + ++C+ P
Sbjct: 530 VDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSP 589

Query: 444 RTQQWTAICPLKERRFGAVACGVAM 468
              +WT    L E   G   C ++M
Sbjct: 590 ELNEWTEDDELPEATVGVSCCTLSM 614


>gi|24308181 kelch-like 9 [Homo sapiens]
          Length = 617

 Score =  187 bits (474), Expect = 3e-47
 Identities = 143/562 (25%), Positives = 250/562 (44%), Gaps = 36/562 (6%)

Query: 12  HAARLLRALSSFREESRFCDAHLVL-DGEEI-PVQKNILAAASPYIRTKLNYNPPKDDGS 69
           H++ +L+     R E   CD  LV  DG+EI PV + ++A+AS Y +        + D  
Sbjct: 32  HSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQD-- 89

Query: 70  TYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCI 129
              I+L G++ + +++I+D+I++ ++ LN D +QD ++AA  L +  +   C  FL   +
Sbjct: 90  LMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGV 149

Query: 130 AAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNV 189
           + +NC+ +   A  Y L  V      ++  +F  + ST EFL+L  ++L  V+S   L  
Sbjct: 150 SLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKH 209

Query: 190 GNERYVFEAVIRWIAHD---TEIRKVHMKDVMSALWVSGLDSSYLR--EQMLNEPLVREI 244
             E  +F+A  RW+  +    +     MK++   L       +Y++  + M  +     +
Sbjct: 210 CTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNL 269

Query: 245 VKECSNIPLSQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQ 304
           + E SN  +    Q          R  S  +VT+GG  R     +  +R    +YD   Q
Sbjct: 270 LLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELR----MYDERAQ 325

Query: 305 LWIELAPLSMPRINHGVLSAEGFLFVFGGQD----ENKQTLSSGEKYDPDANTWTALPPM 360
            W  LAP+  PR  HG+     FL+V GGQ     + K  + +  ++DP  N W  +  +
Sbjct: 326 EWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASL 385

Query: 361 NEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMK 420
           NE R  F +  + G LY +GG     EL ++ECY+     W+    ++            
Sbjct: 386 NEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYG 445

Query: 421 KKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSRE 480
             +Y  GG ++      + C+DP T +W    P+   R     C V  +LYV GG   R 
Sbjct: 446 GLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRG 505

Query: 481 DAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGAS-----IYVIGDL 535
            +   ++++C  E+Y     +W  +          ++ + G   +G +     IYV+G  
Sbjct: 506 TSDYDDVLSC--EYYSPTLDQWTPI----------AAMLRGQSDVGVAVFENKIYVVGGY 553

Query: 536 DTGTN--YDYVREFKRSTGTWH 555
                   + V+++      WH
Sbjct: 554 SWNNRCMVEIVQKYDPEKDEWH 575



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 60/269 (22%), Positives = 102/269 (37%), Gaps = 66/269 (24%)

Query: 252 PLSQP--QQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIEL 309
           P+  P  Q G A++ NF        +  VGG+     K   A+  +   +DP    W+++
Sbjct: 332 PMDAPRYQHGIAVIGNF--------LYVVGGQSNYDTKGKTAVDTVFR-FDPRYNKWMQV 382

Query: 310 APLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNFGI 369
           A L+  R    + + +G L+  GG+    + L++ E Y+P  N W+ +  M+E  +    
Sbjct: 383 ASLNEKRTFFHLSALKGHLYAVGGRSAAGE-LATVECYNPRMNEWSYVAKMSEPHYGHAG 441

Query: 370 VEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCY------------- 416
               G++YI GG   +     + C+D  +  W ++  +T VR + C              
Sbjct: 442 TVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGN 501

Query: 417 ---------------------------------------AAMKKKIYAMGGGSYGK--LF 435
                                                  A  + KIY +GG S+    + 
Sbjct: 502 HFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 561

Query: 436 ESVECYDPRTQQWTAICPLKERRFGAVAC 464
           E V+ YDP   +W  +  L E   G  AC
Sbjct: 562 EIVQKYDPEKDEWHKVFDLPESLGGIRAC 590


>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score =  182 bits (462), Expect = 8e-46
 Identities = 144/559 (25%), Positives = 239/559 (42%), Gaps = 42/559 (7%)

Query: 12  HAARLLRALSSFREESRFCDAHLVLDGEEIPV-----QKNILAAASPYIRTKLNYNPPKD 66
           H  +    ++  R   + CD  L +  ++ P       K +LA++SP  +     N  ++
Sbjct: 59  HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFT-NGLRE 117

Query: 67  DGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 126
            G    + +EGI   VM  ++++ ++  I + E  +  V+  A +  +  +   C +FL 
Sbjct: 118 QGMEV-VSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLV 176

Query: 127 GCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEK 186
             +   N IGI +FA       +H  A EY+  HF +V+  EEF  LS  +L  +IS + 
Sbjct: 177 QQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDD 236

Query: 187 LNVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVRE--- 243
           LNV  E  VF A I W+ +D E R+ +++ ++ A+    L  ++L+ Q+    +++    
Sbjct: 237 LNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSR 296

Query: 244 ----IVKECSNIPLSQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLY 299
               +VK    + L +P Q    +   +       I T GG  R S     A       Y
Sbjct: 297 CKDYLVKIFEELTLHKPTQ----VMPCRAPKVGRLIYTAGGYFRQSLSYLEA-------Y 345

Query: 300 DPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQD---ENKQTLSSGEKYDPDANTWTA 356
           +P+   W+ LA L +PR         G L+  GG++   +     S+ + Y+P  N W+ 
Sbjct: 346 NPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSP 405

Query: 357 LPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGC- 415
             PM+  R+  G+  IDG +Y +GG  G     S+E Y+     W     + + R+IG  
Sbjct: 406 CAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPM-LTRRIGVG 464

Query: 416 YAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGG 475
            A + + +YA+GG        S ECY P   +W  I  +   R GA  C +   +Y  GG
Sbjct: 465 VAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGG 524

Query: 476 VRSREDAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDL 535
              ++     E        Y  E + W ++               G       IYV+G  
Sbjct: 525 YDGQDQLNSVER-------YDVETETWTFVAPMK-----HRRSALGITVHQGRIYVLGGY 572

Query: 536 DTGTNYDYVREFKRSTGTW 554
           D  T  D V  +   T TW
Sbjct: 573 DGHTFLDSVECYDPDTDTW 591



 Score =  101 bits (251), Expect = 2e-21
 Identities = 58/171 (33%), Positives = 83/171 (48%), Gaps = 2/171 (1%)

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALP 358
           Y+P R  W  +AP+   RI  GV      L+  GG D   + L+S E Y P+ N W  + 
Sbjct: 443 YEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR-LNSAECYYPERNEWRMIT 501

Query: 359 PMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAA 418
            MN  R   G+  +   +Y  GG DG+ +L S+E YD+ ++TWT    +   R       
Sbjct: 502 AMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITV 561

Query: 419 MKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAME 469
            + +IY +GG       +SVECYDP T  W+ +  +   R G V   V ME
Sbjct: 562 HQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSG-VGVAVTME 611



 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 46/137 (33%), Positives = 66/137 (48%), Gaps = 7/137 (5%)

Query: 275 IVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQ 334
           +  VGG +  +R  +A        Y P R  W  +  ++  R   GV      ++  GG 
Sbjct: 472 LYAVGGFDGTNRLNSAEC------YYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY 525

Query: 335 DENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECY 394
           D   Q L+S E+YD +  TWT + PM   R   GI    G +Y+LGG DG   L S+ECY
Sbjct: 526 DGQDQ-LNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECY 584

Query: 395 DIYSKTWTKQPDLTMVR 411
           D  + TW++   +T  R
Sbjct: 585 DPDTDTWSEVTRMTSGR 601



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 35/149 (23%), Positives = 55/149 (36%), Gaps = 12/149 (8%)

Query: 415 CYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFG 474
           C A    ++    GG + +    +E Y+P    W  +  L+  R G   C V   LY  G
Sbjct: 319 CRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVG 378

Query: 475 GVRSREDAQ-GSEMVTCKSEFYHDEFKRWIYLNDQNLCIPAS-SSFVYGAVPIGASIYVI 532
           G  +  D    S  + C    Y+    +W      + C P S      G   I   IY +
Sbjct: 379 GRNNSPDGNTDSSALDC----YNPMTNQW------SPCAPMSVPRNRIGVGVIDGHIYAV 428

Query: 533 GDLDTGTNYDYVREFKRSTGTWHHTKPLL 561
           G      +++ V  ++     WH   P+L
Sbjct: 429 GGSHGCIHHNSVERYEPERDEWHLVAPML 457


>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score =  182 bits (462), Expect = 8e-46
 Identities = 144/559 (25%), Positives = 239/559 (42%), Gaps = 42/559 (7%)

Query: 12  HAARLLRALSSFREESRFCDAHLVLDGEEIPV-----QKNILAAASPYIRTKLNYNPPKD 66
           H  +    ++  R   + CD  L +  ++ P       K +LA++SP  +     N  ++
Sbjct: 59  HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFT-NGLRE 117

Query: 67  DGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 126
            G    + +EGI   VM  ++++ ++  I + E  +  V+  A +  +  +   C +FL 
Sbjct: 118 QGMEV-VSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLV 176

Query: 127 GCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEK 186
             +   N IGI +FA       +H  A EY+  HF +V+  EEF  LS  +L  +IS + 
Sbjct: 177 QQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDD 236

Query: 187 LNVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVRE--- 243
           LNV  E  VF A I W+ +D E R+ +++ ++ A+    L  ++L+ Q+    +++    
Sbjct: 237 LNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSR 296

Query: 244 ----IVKECSNIPLSQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLY 299
               +VK    + L +P Q    +   +       I T GG  R S     A       Y
Sbjct: 297 CKDYLVKIFEELTLHKPTQ----VMPCRAPKVGRLIYTAGGYFRQSLSYLEA-------Y 345

Query: 300 DPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQD---ENKQTLSSGEKYDPDANTWTA 356
           +P+   W+ LA L +PR         G L+  GG++   +     S+ + Y+P  N W+ 
Sbjct: 346 NPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSP 405

Query: 357 LPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGC- 415
             PM+  R+  G+  IDG +Y +GG  G     S+E Y+     W     + + R+IG  
Sbjct: 406 CAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPM-LTRRIGVG 464

Query: 416 YAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGG 475
            A + + +YA+GG        S ECY P   +W  I  +   R GA  C +   +Y  GG
Sbjct: 465 VAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGG 524

Query: 476 VRSREDAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDL 535
              ++     E        Y  E + W ++               G       IYV+G  
Sbjct: 525 YDGQDQLNSVER-------YDVETETWTFVAPMK-----HRRSALGITVHQGRIYVLGGY 572

Query: 536 DTGTNYDYVREFKRSTGTW 554
           D  T  D V  +   T TW
Sbjct: 573 DGHTFLDSVECYDPDTDTW 591



 Score =  101 bits (251), Expect = 2e-21
 Identities = 58/171 (33%), Positives = 83/171 (48%), Gaps = 2/171 (1%)

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALP 358
           Y+P R  W  +AP+   RI  GV      L+  GG D   + L+S E Y P+ N W  + 
Sbjct: 443 YEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR-LNSAECYYPERNEWRMIT 501

Query: 359 PMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAA 418
            MN  R   G+  +   +Y  GG DG+ +L S+E YD+ ++TWT    +   R       
Sbjct: 502 AMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITV 561

Query: 419 MKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAME 469
            + +IY +GG       +SVECYDP T  W+ +  +   R G V   V ME
Sbjct: 562 HQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSG-VGVAVTME 611



 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 46/137 (33%), Positives = 66/137 (48%), Gaps = 7/137 (5%)

Query: 275 IVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQ 334
           +  VGG +  +R  +A        Y P R  W  +  ++  R   GV      ++  GG 
Sbjct: 472 LYAVGGFDGTNRLNSAEC------YYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY 525

Query: 335 DENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECY 394
           D   Q L+S E+YD +  TWT + PM   R   GI    G +Y+LGG DG   L S+ECY
Sbjct: 526 DGQDQ-LNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECY 584

Query: 395 DIYSKTWTKQPDLTMVR 411
           D  + TW++   +T  R
Sbjct: 585 DPDTDTWSEVTRMTSGR 601



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 35/149 (23%), Positives = 55/149 (36%), Gaps = 12/149 (8%)

Query: 415 CYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFG 474
           C A    ++    GG + +    +E Y+P    W  +  L+  R G   C V   LY  G
Sbjct: 319 CRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVG 378

Query: 475 GVRSREDAQ-GSEMVTCKSEFYHDEFKRWIYLNDQNLCIPAS-SSFVYGAVPIGASIYVI 532
           G  +  D    S  + C    Y+    +W      + C P S      G   I   IY +
Sbjct: 379 GRNNSPDGNTDSSALDC----YNPMTNQW------SPCAPMSVPRNRIGVGVIDGHIYAV 428

Query: 533 GDLDTGTNYDYVREFKRSTGTWHHTKPLL 561
           G      +++ V  ++     WH   P+L
Sbjct: 429 GGSHGCIHHNSVERYEPERDEWHLVAPML 457


>gi|45643138 kelch-like 13 [Homo sapiens]
          Length = 655

 Score =  182 bits (461), Expect = 1e-45
 Identities = 139/562 (24%), Positives = 246/562 (43%), Gaps = 36/562 (6%)

Query: 12  HAARLLRALSSFREESRFCDAHLVLDGEE--IPVQKNILAAASPYIRTKLNYNPPKDDGS 69
           H++ +L+     R E   CD  L+    +   PV + ++A+AS Y +        + D  
Sbjct: 74  HSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQD-- 131

Query: 70  TYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCI 129
              I+L G+S + +R+I+D+I++ ++ LN D +QD ++AA  L +  +   C  FL   +
Sbjct: 132 LMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGV 191

Query: 130 AAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNV 189
             +NC+ +   A  Y L  V      ++  +F  + ST EFL+L  ++L  V+S   L  
Sbjct: 192 TLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKH 251

Query: 190 GNERYVFEAVIRWIAHD---TEIRKVHMKDVMSALWVSGLDSSYLR--EQMLNEPLVREI 244
             E  +F+A  RW+  +    +     MK++   L       +Y++  + M  +     +
Sbjct: 252 CTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNL 311

Query: 245 VKECSNIPLSQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQ 304
           + E SN  +    Q          R  +  +VT+GG  R     +  +R    +YD    
Sbjct: 312 LLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELR----MYDEKAH 367

Query: 305 LWIELAPLSMPRINHGVLSAEGFLFVFGGQD----ENKQTLSSGEKYDPDANTWTALPPM 360
            W  LAP+  PR  HG+     FL+V GGQ     + K  + +  ++DP  N W  +  +
Sbjct: 368 EWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASL 427

Query: 361 NEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMK 420
           NE R  F +  + G LY +GG +   EL ++ECY+  +  WT    ++            
Sbjct: 428 NEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYG 487

Query: 421 KKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSRE 480
             +Y  GG ++    + + C+DP T +W    P+   R     C V   LYV GG   R 
Sbjct: 488 GVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRG 547

Query: 481 DAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGAS-----IYVIGDL 535
            +   ++++C  E+Y     +W  +          ++ + G   +G +     IYV+G  
Sbjct: 548 TSDYDDVLSC--EYYSPILDQWTPI----------AAMLRGQSDVGVAVFENKIYVVGGY 595

Query: 536 DTGTN--YDYVREFKRSTGTWH 555
                   + V+++      WH
Sbjct: 596 SWNNRCMVEIVQKYDPDKDEWH 617



 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 61/269 (22%), Positives = 103/269 (38%), Gaps = 66/269 (24%)

Query: 252 PLSQP--QQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIEL 309
           P+  P  Q G A++ NF        +  VGG+     K   A+  +   +DP    W+++
Sbjct: 374 PMDAPRYQHGIAVIGNF--------LYVVGGQSNYDTKGKTAVDTVFR-FDPRYNKWMQV 424

Query: 310 APLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNFGI 369
           A L+  R    + + +G+L+  GG++   + L + E Y+P  N WT +  M+E  +    
Sbjct: 425 ASLNEKRTFFHLSALKGYLYAVGGRNAAGE-LPTVECYNPRTNEWTYVAKMSEPHYGHAG 483

Query: 370 VEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCY------------- 416
               G++YI GG   +     + C+D  +  W ++  +T VR + C              
Sbjct: 484 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN 543

Query: 417 ---------------------------------------AAMKKKIYAMGGGSYGK--LF 435
                                                  A  + KIY +GG S+    + 
Sbjct: 544 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 603

Query: 436 ESVECYDPRTQQWTAICPLKERRFGAVAC 464
           E V+ YDP   +W  +  L E   G  AC
Sbjct: 604 EIVQKYDPDKDEWHKVFDLPESLGGIRAC 632


>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
          Length = 589

 Score =  176 bits (445), Expect = 7e-44
 Identities = 126/522 (24%), Positives = 232/522 (44%), Gaps = 62/522 (11%)

Query: 12  HAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTY 71
           H   +L  L++ R+   F D  L       P  + +LAA+S Y     ++   +    T 
Sbjct: 28  HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTV 87

Query: 72  KIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAA 131
             + + +   V+  +LD+ +S +I +NE+  + +++A D+L   D++    EFLE  +  
Sbjct: 88  NFQ-DNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFP 146

Query: 132 ENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGN 191
            NC+G+   +  +    ++  +      HF  V  +E+F  LS   L ++IS ++L   +
Sbjct: 147 SNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETED 206

Query: 192 ERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLV-----REIVK 246
           ER VFEA+++W+ HD E RKVH+ +++ ++ ++ L S  L+E + +E L+      +++ 
Sbjct: 207 ERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIM 266

Query: 247 ECSNIPLSQPQQGEAMLAN--FKPRGYSECIVTVGGEERV-------------------- 284
           + +    ++  Q + ++ +   +PR     ++ +GG+  +                    
Sbjct: 267 DEALRCKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADL 326

Query: 285 --SRKPTAAMRCMCP------------------LYDPNRQLWIELAPLSMPRINHGVLSA 324
              RK  +A    C                   +YD   + W + AP+ + R  HG    
Sbjct: 327 PSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAEL 386

Query: 325 EGFLFVFGGQD--------ENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGML 376
           E  L+V GG              +L   EKYDP AN W  + P+ +   N  +V     L
Sbjct: 387 ENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKL 446

Query: 377 YILGGEDGEKELIS-MECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLF 435
           ++ GG    ++++S ++CYD     WT + +     +    A +  +I+ MGG +    F
Sbjct: 447 FVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTE---F 503

Query: 436 ESVECY--DPRTQQWTAICPLKERRFGAVACGVAMELYVFGG 475
            +   Y  D  T QWT I  +  +R    A     +LYV GG
Sbjct: 504 TAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGG 545



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 53/183 (28%), Positives = 89/183 (48%), Gaps = 8/183 (4%)

Query: 274 CIVTVGGEERVS----RKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLF 329
           C+  VGG   ++      P+ +++     YDP    W+ +APL     N  V+SA+  LF
Sbjct: 389 CLYVVGGHTSLAGVFPASPSVSLK-QVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLF 447

Query: 330 VFGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELI 389
           VFGG   ++  +S  + YDP  N WT      +         +   ++I+GG D E    
Sbjct: 448 VFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFTAA 506

Query: 390 SMECYDIYSKTWTKQPDLTMVRKIGCYA-AMKKKIYAMGGGSYGKLFESVECYDPRTQQW 448
           S   +D  +  WT+  D+T  +++ C+A A   K+Y +GG    +  ++++CYDP +  W
Sbjct: 507 SAYRFDCETNQWTRIGDMT-AKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTW 565

Query: 449 TAI 451
             I
Sbjct: 566 NCI 568


>gi|8922854 kelch-like 26 [Homo sapiens]
          Length = 615

 Score =  174 bits (441), Expect = 2e-43
 Identities = 143/562 (25%), Positives = 237/562 (42%), Gaps = 29/562 (5%)

Query: 8   SDPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDD 67
           S P H+  LL+ L++ R + +  D  L ++ E  P  K +LAA S Y R    +     +
Sbjct: 41  SAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAM--FTGGMRE 98

Query: 68  GSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEG 127
            S   IEL+G+S   +R I+D+ +S ++ L+ D +QDV+ AA  L +  +  LC EFL+ 
Sbjct: 99  ASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKA 158

Query: 128 CIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKL 187
            ++ E C+ I   A  + L  +      +   HF  ++  E+FL L  ++L   +   +L
Sbjct: 159 AMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRL 218

Query: 188 NVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQ------MLNEPLV 241
               E  +F A +RW+ HD   R+     V+  +    + SS L +       M+ + L 
Sbjct: 219 QSCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLC 277

Query: 242 REIVKECSNIPLSQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYDP 301
           R+ + E  N  +   +Q E        R     +VT GG        + + + +  L +P
Sbjct: 278 RQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSK-VYQLPEP 336

Query: 302 NRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQD----ENKQTLSSGEKYDPDANTWTAL 357
             + + EL  + +   +  V   + F++V GGQ       +  + +  +YDP  N W  L
Sbjct: 337 GARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRL 396

Query: 358 PPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYA 417
             M E+R  F +  + GM+Y  GG +    L S+E Y      W     L         A
Sbjct: 397 QAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGA 456

Query: 418 AMKKKIYAMGGGSYGKLFE---SVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFG 474
           A   ++Y  GG  YG   E   ++ CYDP   QW    P+ E R      G    +Y  G
Sbjct: 457 ASGGRLYISGG--YGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALG 514

Query: 475 GVRSREDAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGD 534
           G     D     +     E+Y  E  +W  ++        +     G   +   IY++G 
Sbjct: 515 GRMDHVDRCFDVLAV---EYYVPETDQWTSVSPMR-----AGQSEAGCCLLERKIYIVGG 566

Query: 535 LDTGTN--YDYVREFKRSTGTW 554
            +   N     V+ +   T  W
Sbjct: 567 YNWRLNNVTGIVQVYNTDTDEW 588


>gi|34101268 kelch-like 8 [Homo sapiens]
          Length = 620

 Score =  174 bits (440), Expect = 3e-43
 Identities = 133/545 (24%), Positives = 230/545 (42%), Gaps = 28/545 (5%)

Query: 19  ALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELEGI 78
           +L  F E    CD  L +  + I   K +LA   PY R    +     +     IE+   
Sbjct: 56  SLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAM--FLSEMAEAKQTLIEIRDF 113

Query: 79  SVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGIR 138
               + +++ +++S ++ L  D +Q ++ AA +L +  +   CCE+++      NC+ +R
Sbjct: 114 DGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVR 173

Query: 139 DFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEA 198
            FA  +    +  +A +Y   HF +V   E+F+ +SPQ L +++S   LN+ NE+ V+ A
Sbjct: 174 AFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNA 233

Query: 199 VIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYL-----REQMLNEPL-VREIVKECSNIP 252
            I+W+  + +     + + ++ + +  L   +L     +EQ++ + L  R+++ E  N  
Sbjct: 234 AIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYH 293

Query: 253 L---SQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIEL 309
           L   S+            PR ++  ++   G    S  P  ++ C    Y  N+  W   
Sbjct: 294 LHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIEC----YSINKNSWFFG 349

Query: 310 APLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNFGI 369
             ++  R + GV+S EG ++  GG D N+  L S E +DP  N W     MN  R    +
Sbjct: 350 PEMNSRRRHVGVISVEGKVYAVGGHDGNEH-LGSMEMFDPLTNKWMMKASMNTKRRGIAL 408

Query: 370 VEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGG 429
             + G +Y +GG D       +E YDI S  W+    +   R      A+   +YA+GG 
Sbjct: 409 ASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGN 468

Query: 430 SYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDAQGSEMVT 489
                  SVE YDP   +W  +  + +RR G     +   LYV GG          E   
Sbjct: 469 DGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVER-- 526

Query: 490 CKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVREFKR 549
                Y     +W Y+    L  P       G   +   I+ +G  +     + V  F  
Sbjct: 527 -----YDPRSNKWDYV--AALTTPRGG---VGIATVMGKIFAVGGHNGNAYLNTVEAFDP 576

Query: 550 STGTW 554
               W
Sbjct: 577 VLNRW 581



 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 55/170 (32%), Positives = 83/170 (48%), Gaps = 4/170 (2%)

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALP 358
           YD     W  +AP++ PR   G ++    ++  GG D    +LSS E+YDP  + W  + 
Sbjct: 433 YDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGND-GMASLSSVERYDPHLDKWIEVK 491

Query: 359 PMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAA 418
            M + R   G+ ++ G LY++GG D    L S+E YD  S  W     LT  R     A 
Sbjct: 492 EMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIAT 551

Query: 419 MKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAM 468
           +  KI+A+GG +      +VE +DP   +W  +  +   R GA   GVA+
Sbjct: 552 VMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGA---GVAV 598


>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
          Length = 586

 Score =  172 bits (437), Expect = 6e-43
 Identities = 130/564 (23%), Positives = 251/564 (44%), Gaps = 60/564 (10%)

Query: 14  ARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKI 73
           A  +  +++ R++   CD  L++   +IP  + +LAAAS +       N    +  ++++
Sbjct: 28  AGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNML--ESKSFEV 85

Query: 74  ELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAEN 133
           EL+     ++ +++++ ++ +I +N + +Q ++ AA+   +  +K +C +FL+  + A N
Sbjct: 86  ELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASN 145

Query: 134 CIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNER 193
           C+GI   A       +   A +++  HF +V  T+EFL+L  +++  +++ + L V  E 
Sbjct: 146 CLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAED 205

Query: 194 YVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKECSNIPL 253
            V++A +RW+ +D   R+  M D+++ +    +  ++L + +  EPL+++   EC  + +
Sbjct: 206 QVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQD-NPECLKMVI 264

Query: 254 S-------QPQQGEAMLANFKPR--GYSECIVTVGGEERVS-----RKPTAAMRCMCPL- 298
           S        P+  E ++   +PR   +   I   GG +  S      K  +     CP  
Sbjct: 265 SGMRYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFE 324

Query: 299 ------------------------------YDPNRQLWIELAPLSMPRINHGVLSAEGFL 328
                                         Y+  +  W        PR +    +AEG +
Sbjct: 325 KRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKI 384

Query: 329 FVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGEDGE--- 385
           +  GG +     L   E YD    +W   P M   R + G+VE +G++Y+ GG  G    
Sbjct: 385 YTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVS 444

Query: 386 -KELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPR 444
            + L S E YD  ++TWT+   +   RK      +K KI+A+GG +     ++VE YD +
Sbjct: 445 GRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIK 504

Query: 445 TQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDAQGSEMVTCKSEFYHDEFKRWIY 504
             +W  + P+  +        V   +YV  G       QG   +    E Y+ E  +W+ 
Sbjct: 505 LNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGF------QGVGRLGHILE-YNTETDKWV- 556

Query: 505 LNDQNLCIPASSSFVYGAVPIGAS 528
            N +    P +S  +      GA+
Sbjct: 557 ANSKVRAFPVTSCLICVVDTCGAN 580


>gi|109150407 kelch-like 6 [Homo sapiens]
          Length = 621

 Score =  171 bits (432), Expect = 2e-42
 Identities = 131/483 (27%), Positives = 225/483 (46%), Gaps = 40/483 (8%)

Query: 16  LLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIEL 75
           L   L + R E+   D  L +D +E    + +LAAAS Y R     N  K+     +I +
Sbjct: 58  LQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMF-CNDLKEKYEK-RIII 115

Query: 76  EGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCI 135
           +G+    M  +LDY ++ +  + +  +Q V++AA+L     +   C  FL   +  ENC+
Sbjct: 116 KGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCV 175

Query: 136 GIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYV 195
           GI   A  + L  +      Y+  +F  + ++EEFL+L    L  ++  + L V  E  V
Sbjct: 176 GILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQV 235

Query: 196 FEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKECSNI-PLS 254
           FE V+ W+ H    R   +  V+  + +  LD  Y  E +  +PL+R    +C  + PL 
Sbjct: 236 FETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIR----QCPEVFPLL 291

Query: 255 QPQQ------GEAMLANFKPRGY---SECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQL 305
           Q  +       E +    KPR +   SE  + +GG  +  R   A + C+    DP R+ 
Sbjct: 292 QEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERF-VAEVTCL----DPLRRS 346

Query: 306 WIELAPLSMPR----------INHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWT 355
            +E+A L +            +    ++ +  +++ GG    K+T     KY+   N W 
Sbjct: 347 RLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGG----KETQHDVWKYNSSINKWI 402

Query: 356 ALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGC 415
            +  +N  R    +V + G +Y++GG DG + + ++E YD +   W++   L +      
Sbjct: 403 QIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFA 462

Query: 416 YAAMKKKIYAMGGGSYGKL-FESVECYDPRTQQWT--AICPLKERRFGAVACGVAMELYV 472
             + KKK+Y +GGG  GKL  +  +CYDP T +W+  A  P++ +   AV+      +YV
Sbjct: 463 ATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVS--FRDRIYV 520

Query: 473 FGG 475
            GG
Sbjct: 521 VGG 523



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 40/157 (25%), Positives = 61/157 (38%), Gaps = 6/157 (3%)

Query: 299 YDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALP 358
           YDP    W E APL +   +    S +  L+V GG    K      + YDP  N W+   
Sbjct: 441 YDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKA 500

Query: 359 PMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAA 418
            M         V     +Y++GG      + ++  Y     +W     L+  R     A 
Sbjct: 501 AMPVEAKCINAVSFRDRIYVVGGA-----MRALYAYSPLEDSWCLVTQLSHERASCGIAP 555

Query: 419 MKKKIYAMGG-GSYGKLFESVECYDPRTQQWTAICPL 454
              ++Y  GG     ++  +V C+DP  Q+ T  C L
Sbjct: 556 CNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVL 592



 Score = 36.6 bits (83), Expect = 0.067
 Identities = 23/84 (27%), Positives = 40/84 (47%), Gaps = 2/84 (2%)

Query: 272 SECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVF 331
           ++CI  V   +R+      AMR +   Y P    W  +  LS  R + G+      L++ 
Sbjct: 506 AKCINAVSFRDRIY-VVGGAMRALYA-YSPLEDSWCLVTQLSHERASCGIAPCNNRLYIT 563

Query: 332 GGQDENKQTLSSGEKYDPDANTWT 355
           GG+DE  + +++   +DP+A   T
Sbjct: 564 GGRDEKNEVIATVLCWDPEAQKLT 587



 Score = 33.5 bits (75), Expect = 0.57
 Identities = 32/134 (23%), Positives = 52/134 (38%), Gaps = 25/134 (18%)

Query: 438 VECYDP--RTQQWTAICPLKE-------RRFGAVAC-GVAMELYVFGGVRSREDAQGSEM 487
           V C DP  R++   A  PL E       +++   AC  +  E+Y+ GG  ++ D      
Sbjct: 337 VTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWK--- 393

Query: 488 VTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVREF 547
                  Y+    +WI +   N+       + +  V +G  +YVIG  D     + V  +
Sbjct: 394 -------YNSSINKWIQIEYLNI-----GRWRHKMVVLGGKVYVIGGFDGLQRINNVETY 441

Query: 548 KRSTGTWHHTKPLL 561
                 W    PLL
Sbjct: 442 DPFHNCWSEAAPLL 455


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,904,577
Number of Sequences: 37866
Number of extensions: 1022577
Number of successful extensions: 3303
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 164
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 2155
Number of HSP's gapped (non-prelim): 378
length of query: 597
length of database: 18,247,518
effective HSP length: 108
effective length of query: 489
effective length of database: 14,157,990
effective search space: 6923257110
effective search space used: 6923257110
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.