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Search of human proteins with 115430257
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115430257 solute carrier family 25, member 26 [Homo sapiens]
(274 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115430257 solute carrier family 25, member 26 [Homo sapiens] 546 e-156
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 100 1e-21
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 99 4e-21
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 99 4e-21
gi|13449279 solute carrier family 25 (mitochondrial oxodicarboxy... 97 1e-20
gi|82775373 solute carrier family 25, member 37 [Homo sapiens] 92 5e-19
gi|13899342 solute carrier [Homo sapiens] 91 1e-18
gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens] 91 1e-18
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 84 2e-16
gi|149274643 solute carrier family 25, member 28 [Homo sapiens] 84 2e-16
gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens] 83 3e-16
gi|157388925 solute carrier family 25, member 38 [Homo sapiens] 77 1e-14
gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens] 77 2e-14
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ... 77 2e-14
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s... 77 2e-14
gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 75 5e-14
gi|239755174 PREDICTED: similar to solute carrier family 25, mem... 75 5e-14
gi|13994341 solute carrier family 25 member 2 [Homo sapiens] 75 5e-14
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ... 75 5e-14
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ... 75 5e-14
gi|86198310 solute carrier family 25, member 29 [Homo sapiens] 75 5e-14
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ... 75 5e-14
gi|56699403 solute carrier family 25, member 25 isoform b [Homo ... 75 5e-14
gi|45237193 solute carrier family 25, member 44 isoform 1 [Homo ... 75 6e-14
gi|58197562 solute carrier family 25, member 30 [Homo sapiens] 74 1e-13
gi|11225256 uncoupling protein 1 [Homo sapiens] 74 1e-13
gi|21314739 solute carrier family 25, member 32 [Homo sapiens] 74 1e-13
gi|48476342 solute carrier family 25, member 23 [Homo sapiens] 72 7e-13
gi|7706306 solute carrier family 25, member 39 isoform b [Homo s... 71 9e-13
gi|219555665 solute carrier family 25, member 39 isoform a [Homo... 71 9e-13
>gi|115430257 solute carrier family 25, member 26 [Homo sapiens]
Length = 274
Score = 546 bits (1406), Expect = e-156
Identities = 274/274 (100%), Positives = 274/274 (100%)
Query: 1 MDRPGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKAGGFHGIYAGVPSAAIGS 60
MDRPGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKAGGFHGIYAGVPSAAIGS
Sbjct: 1 MDRPGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKAGGFHGIYAGVPSAAIGS 60
Query: 61 FPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRAQVSA 120
FPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRAQVSA
Sbjct: 61 FPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRAQVSA 120
Query: 121 STRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQDHVVDSW 180
STRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQDHVVDSW
Sbjct: 121 STRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQDHVVDSW 180
Query: 181 QSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGVWRSQGLAGLFAG 240
QSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGVWRSQGLAGLFAG
Sbjct: 181 QSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGVWRSQGLAGLFAG 240
Query: 241 VFPRMAAISLGGFIFLGAYDRTHSLLLEVGRKSP 274
VFPRMAAISLGGFIFLGAYDRTHSLLLEVGRKSP
Sbjct: 241 VFPRMAAISLGGFIFLGAYDRTHSLLLEVGRKSP 274
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 100 bits (250), Expect = 1e-21
Identities = 77/254 (30%), Positives = 112/254 (44%), Gaps = 23/254 (9%)
Query: 13 GGVAGVSVDLILFPLDTIKTRLQSPQG----------------FNKA---GGFHGIYAGV 53
G VAG ++P+D +KTR+Q+ +G F K GF G+Y G+
Sbjct: 333 GSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGL 392
Query: 54 PSAAIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVK 113
IG P A ++V+ S P + + AG P E+VK
Sbjct: 393 IPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTN-PLEIVK 451
Query: 114 QRAQVSASTRTFQIFS--NILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSW 171
R QV+ T S N+L + GI GLY+G K+ LR+IPFS + FP++ K L +
Sbjct: 452 IRLQVAGEITTGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLAD 511
Query: 172 RQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGVWRS 231
H V GA AG AA++ TP DV KTR+ +A T V+ + R
Sbjct: 512 ENGH-VGGLNLLAAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILRE 570
Query: 232 QGLAGLFAGVFPRM 245
+G + + G R+
Sbjct: 571 EGPSAFWKGTAARV 584
Score = 61.2 bits (147), Expect = 9e-10
Identities = 49/176 (27%), Positives = 78/176 (44%), Gaps = 18/176 (10%)
Query: 8 AALVAGGVAGVSVDLILFPLDTIKTRLQ-----------SPQGFNKAGGFHGIYAGVPSA 56
A ++AGG AG S + PL+ +K RLQ S + G G+Y G +
Sbjct: 428 AEVLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLRDLGIFGLYKGAKAC 487
Query: 57 AIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRA 116
+ P +A +F Y + K L AD + ++ + + A + V A + P++V+K R
Sbjct: 488 FLRDIPFSAIYFPVYAHCKLLL-ADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRL 546
Query: 117 QVSAS------TRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLK 166
QV+A + F IL EEG ++G + V R P V +E L+
Sbjct: 547 QVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQ 602
Score = 35.4 bits (80), Expect = 0.054
Identities = 24/84 (28%), Positives = 38/84 (45%), Gaps = 8/84 (9%)
Query: 171 WRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADG-----NVLSVL 225
W Q + +S G+ AG A P+D+ KTR M + GS + G N
Sbjct: 320 WLQ--IAESAYRFTLGSVAGAVGATAVYPIDLVKTR-MQNQRGSGSVVGELMYKNSFDCF 376
Query: 226 HGVWRSQGLAGLFAGVFPRMAAIS 249
V R +G GL+ G+ P++ ++
Sbjct: 377 KKVLRYEGFFGLYRGLIPQLIGVA 400
Score = 31.2 bits (69), Expect = 1.0
Identities = 24/89 (26%), Positives = 35/89 (39%), Gaps = 16/89 (17%)
Query: 5 GFVAALVAGGVAGVSVDLILFPLDTIKTRLQSP---------------QGFNKAGGFHGI 49
G + L AG +AGV ++ P D IKTRLQ + + G
Sbjct: 517 GGLNLLAAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAF 576
Query: 50 YAGVPSAAIGSFPNAAAFFITYEYV-KWF 77
+ G + S P +TYE + +WF
Sbjct: 577 WKGTAARVFRSSPQFGVTLVTYELLQRWF 605
>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
sapiens]
Length = 675
Score = 99.0 bits (245), Expect = 4e-21
Identities = 75/255 (29%), Positives = 117/255 (45%), Gaps = 25/255 (9%)
Query: 13 GGVAGVSVDLILFPLDTIKTRLQSPQG----------------FNKA---GGFHGIYAGV 53
G VAG ++P+D +KTR+Q+ + F K GF G+Y G+
Sbjct: 335 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGL 394
Query: 54 PSAAIGSFPNAAAFFITYEYVK-WFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVV 112
+G P A ++V+ F+H D S L +LA + P E+V
Sbjct: 395 LPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAA--EILAGGCAGGSQVIFTNPLEIV 452
Query: 113 KQRAQVSASTRTFQIFS--NILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWS 170
K R QV+ T S +++ + G G+Y+G K+ LR+IPFS + FP + +KA ++
Sbjct: 453 KIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFA 512
Query: 171 WRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGVWR 230
+D V + GA AG AA++ TP DV KTR+ +A T V+ + R
Sbjct: 513 -NEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILR 571
Query: 231 SQGLAGLFAGVFPRM 245
+G L+ G R+
Sbjct: 572 EEGPKALWKGAGARV 586
Score = 64.7 bits (156), Expect = 8e-11
Identities = 49/163 (30%), Positives = 76/163 (46%), Gaps = 18/163 (11%)
Query: 8 AALVAGGVAGVSVDLILFPLDTIKTRLQ-----------SPQGFNKAGGFHGIYAGVPSA 56
A ++AGG AG S + PL+ +K RLQ S + GF GIY G +
Sbjct: 430 AEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKAC 489
Query: 57 AIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRA 116
+ P +A +F Y +VK A+ ++P +LA + + A + P++V+K R
Sbjct: 490 FLRDIPFSAIYFPCYAHVK-ASFANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRL 548
Query: 117 QVSAS------TRTFQIFSNILYEEGIQGLYRGYKSTVLREIP 153
QV+A + F IL EEG + L++G + V R P
Sbjct: 549 QVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSP 591
Score = 30.8 bits (68), Expect = 1.3
Identities = 22/84 (26%), Positives = 35/84 (41%), Gaps = 16/84 (19%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSP---------------QGFNKAGGFHGIYAGVP 54
L+AG +AG+ ++ P D IKTRLQ + + G ++ G
Sbjct: 524 LLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPKALWKGAG 583
Query: 55 SAAIGSFPNAAAFFITYEYV-KWF 77
+ S P +TYE + +WF
Sbjct: 584 ARVFRSSPQFGVTLLTYELLQRWF 607
>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
sapiens]
Length = 676
Score = 99.0 bits (245), Expect = 4e-21
Identities = 75/255 (29%), Positives = 117/255 (45%), Gaps = 25/255 (9%)
Query: 13 GGVAGVSVDLILFPLDTIKTRLQSPQG----------------FNKA---GGFHGIYAGV 53
G VAG ++P+D +KTR+Q+ + F K GF G+Y G+
Sbjct: 336 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGL 395
Query: 54 PSAAIGSFPNAAAFFITYEYVK-WFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVV 112
+G P A ++V+ F+H D S L +LA + P E+V
Sbjct: 396 LPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAA--EILAGGCAGGSQVIFTNPLEIV 453
Query: 113 KQRAQVSASTRTFQIFS--NILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWS 170
K R QV+ T S +++ + G G+Y+G K+ LR+IPFS + FP + +KA ++
Sbjct: 454 KIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFA 513
Query: 171 WRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGVWR 230
+D V + GA AG AA++ TP DV KTR+ +A T V+ + R
Sbjct: 514 -NEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILR 572
Query: 231 SQGLAGLFAGVFPRM 245
+G L+ G R+
Sbjct: 573 EEGPKALWKGAGARV 587
Score = 64.7 bits (156), Expect = 8e-11
Identities = 49/163 (30%), Positives = 76/163 (46%), Gaps = 18/163 (11%)
Query: 8 AALVAGGVAGVSVDLILFPLDTIKTRLQ-----------SPQGFNKAGGFHGIYAGVPSA 56
A ++AGG AG S + PL+ +K RLQ S + GF GIY G +
Sbjct: 431 AEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKAC 490
Query: 57 AIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRA 116
+ P +A +F Y +VK A+ ++P +LA + + A + P++V+K R
Sbjct: 491 FLRDIPFSAIYFPCYAHVK-ASFANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRL 549
Query: 117 QVSAS------TRTFQIFSNILYEEGIQGLYRGYKSTVLREIP 153
QV+A + F IL EEG + L++G + V R P
Sbjct: 550 QVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSP 592
Score = 30.8 bits (68), Expect = 1.3
Identities = 22/84 (26%), Positives = 35/84 (41%), Gaps = 16/84 (19%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSP---------------QGFNKAGGFHGIYAGVP 54
L+AG +AG+ ++ P D IKTRLQ + + G ++ G
Sbjct: 525 LLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPKALWKGAG 584
Query: 55 SAAIGSFPNAAAFFITYEYV-KWF 77
+ S P +TYE + +WF
Sbjct: 585 ARVFRSSPQFGVTLLTYELLQRWF 608
>gi|13449279 solute carrier family 25 (mitochondrial
oxodicarboxylate carrier), member 21 [Homo sapiens]
Length = 299
Score = 97.4 bits (241), Expect = 1e-20
Identities = 76/287 (26%), Positives = 128/287 (44%), Gaps = 34/287 (11%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQ------SPQGFN----------KAGGFHGIYAGV 53
+VAGG AG+ ++ PLD +KTR Q P + + G G Y G+
Sbjct: 17 IVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGI 76
Query: 54 PSAAIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVK 113
+ P A F T+E K L S S + +A + ++ P EVVK
Sbjct: 77 LPPILAETPKRAVKFFTFEQYKKLLGYVSLS--PALTFAIAGLGSGLTEAIVVNPFEVVK 134
Query: 114 QRAQVSAST-----RTFQIFSNILYEEG--IQGLYRGYKSTVLREIPFSLVQFPLWESLK 166
Q + +T T I+ +EG +QGL +G +T+ R F++V F + ++K
Sbjct: 135 VGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVK 194
Query: 167 ALWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNV----- 221
+ +D +++ W+ G +G A+ + P DVAK+RI G G +
Sbjct: 195 NMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQ----GPQPVPGEIKYRTC 250
Query: 222 LSVLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAYDRTHSLLLE 268
+ V++ +G+ L+ G+ P++ + GG + L Y+ T+S L E
Sbjct: 251 FKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQE 297
Score = 32.3 bits (72), Expect = 0.46
Identities = 19/73 (26%), Positives = 36/73 (49%), Gaps = 1/73 (1%)
Query: 176 VVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAK-AGSSTADGNVLSVLHGVWRSQGL 234
V ++ + V G AG + PLDV KTR + + A + +++ +++ +GL
Sbjct: 10 VREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGL 69
Query: 235 AGLFAGVFPRMAA 247
G + G+ P + A
Sbjct: 70 FGFYKGILPPILA 82
>gi|82775373 solute carrier family 25, member 37 [Homo sapiens]
Length = 338
Score = 92.0 bits (227), Expect = 5e-19
Identities = 76/263 (28%), Positives = 118/263 (44%), Gaps = 32/263 (12%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKA---------------GGFHGIYAGVP 54
+ AG +AG+ +++P+D++KTR+QS KA GF GV
Sbjct: 49 MTAGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWRPLRGVN 108
Query: 55 SAAIGSFPNAAAFFITYEYVKWFL----HADSSSYLTPMKHMLAASAGEVVACLIRVPSE 110
+G+ P A +F YE +K L H +S+L + +A S ++ + P+E
Sbjct: 109 VMIMGAGPAHAMYFACYENMKRTLNDVFHHQGNSHLA---NGIAGSMATLLHDAVMNPAE 165
Query: 111 VVKQRAQV--SASTRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKAL 168
VVKQR Q+ S + EG+ YR Y + + IPF + F +E L+
Sbjct: 166 VVKQRLQMYNSQHRSAISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQ 225
Query: 169 WSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKT------RIMLAKAGSSTADGNVL 222
+ + + S + G AG AAA TTPLDV KT + L+ A S +
Sbjct: 226 VNPHRTYNPQS--HIISGGLAGALAAAATTPLDVCKTLLNTQENVALSLANISGRLSGMA 283
Query: 223 SVLHGVWRSQGLAGLFAGVFPRM 245
+ V++ GLAG F G+ R+
Sbjct: 284 NAFRTVYQLNGLAGYFKGIQARV 306
Score = 33.5 bits (75), Expect = 0.21
Identities = 23/90 (25%), Positives = 37/90 (41%), Gaps = 21/90 (23%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQGF-----NKAG----------------GFHG 48
+++GG+AG PLD KT L + + N +G G G
Sbjct: 238 IISGGLAGALAAAATTPLDVCKTLLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAG 297
Query: 49 IYAGVPSAAIGSFPNAAAFFITYEYVKWFL 78
+ G+ + I P+ A + YE+ K+FL
Sbjct: 298 YFKGIQARVIYQMPSTAISWSVYEFFKYFL 327
>gi|13899342 solute carrier [Homo sapiens]
Length = 315
Score = 90.9 bits (224), Expect = 1e-18
Identities = 83/301 (27%), Positives = 119/301 (39%), Gaps = 48/301 (15%)
Query: 8 AALVAGGVAGVSVDLILFPLDTIKTRLQSPQG-------------FNKAGGFHGIYAGVP 54
A L+ GGVAG+ +FP+D KTRLQ+ G +A GF G+Y G
Sbjct: 10 AKLINGGVAGLVGVTCVFPIDLAKTRLQNQHGKAMYKGMIDCLMKTARAEGFFGMYRGAA 69
Query: 55 SAAIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVK- 113
P A ++ + L D M+ MLA + ++ P E++K
Sbjct: 70 VNLTLVTPEKAIKLAANDFFRRLLMEDGMQRNLKME-MLAGCGAGMCQVVVTCPMEMLKI 128
Query: 114 ---------------------QRAQVSASTRTFQ------IFSNILYEEGIQGLYRGYKS 146
R+ + S T + I +L +G+ GLYRG +
Sbjct: 129 QLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSATLIAWELLRTQGLAGLYRGLGA 188
Query: 147 TVLREIPFSLVQFPLWESLKALWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTR 206
T+LR+IPFS++ FPL+ +L L S V G AG AA TPLDV KTR
Sbjct: 189 TLLRDIPFSIIYFPLFANLNNLGFNELAGKASFAHSFVSGCVAGSIAAVAVTPLDVLKTR 248
Query: 207 IMLAKAG-SSTADGNVLSVLHGVWRSQGLAGLFAGVFPRMAAIS-----LGGFIFLGAYD 260
I K G + +W +G + G R I+ G F+G +
Sbjct: 249 IQTLKKGLGEDMYSGITDCARKLWIQEGPSAFMKGAGCRALVIAPLFGIAQGVYFIGIGE 308
Query: 261 R 261
R
Sbjct: 309 R 309
Score = 32.0 bits (71), Expect = 0.60
Identities = 20/52 (38%), Positives = 29/52 (55%), Gaps = 8/52 (15%)
Query: 6 FVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKAGGFHGIYAGVPSAA 57
FV+ VAG +A V+V PLD +KTR+Q+ K G +Y+G+ A
Sbjct: 225 FVSGCVAGSIAAVAVT----PLDVLKTRIQT----LKKGLGEDMYSGITDCA 268
Score = 31.6 bits (70), Expect = 0.78
Identities = 24/85 (28%), Positives = 39/85 (45%), Gaps = 2/85 (2%)
Query: 186 GAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGVWRSQGLAGLFAGVFPRM 245
G AG P+D+AKTR+ + G + G ++ L R++G G++ G +
Sbjct: 15 GGVAGLVGVTCVFPIDLAKTRLQ-NQHGKAMYKG-MIDCLMKTARAEGFFGMYRGAAVNL 72
Query: 246 AAISLGGFIFLGAYDRTHSLLLEVG 270
++ I L A D LL+E G
Sbjct: 73 TLVTPEKAIKLAANDFFRRLLMEDG 97
>gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens]
Length = 323
Score = 90.5 bits (223), Expect = 1e-18
Identities = 73/288 (25%), Positives = 118/288 (40%), Gaps = 47/288 (16%)
Query: 8 AALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNK--------------AGGFHGIYAGV 53
A L+ GG+AG+ +FP+D KTRLQ+ Q + + G+ G+Y G
Sbjct: 10 AKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGA 69
Query: 54 PSAAIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVK 113
P A ++ + L D LT +K MLA ++ P E++K
Sbjct: 70 AVNLTLVTPEKAIKLAANDFFRHQLSKDGQK-LTLLKEMLAGCGAGTCQVIVTTPMEMLK 128
Query: 114 QRAQ----VSASTRTF---------------------------QIFSNILYEEGIQGLYR 142
+ Q ++A + Q+ ++L GI GLY+
Sbjct: 129 IQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYK 188
Query: 143 GYKSTVLREIPFSLVQFPLWESLKALWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDV 202
G +T+LR++PFS+V FPL+ +L L + + S + G AG AA P DV
Sbjct: 189 GLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDV 248
Query: 203 AKTRIMLAKAG-SSTADGNVLSVLHGVWRSQGLAGLFAGVFPRMAAIS 249
KTR+ + G + +L + R +G + G + R I+
Sbjct: 249 VKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIA 296
Score = 31.2 bits (69), Expect = 1.0
Identities = 15/37 (40%), Positives = 23/37 (62%)
Query: 2 DRPGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQ 38
++ F + +AG VAG + + + P D +KTRLQS Q
Sbjct: 221 EKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQ 257
Score = 30.0 bits (66), Expect = 2.3
Identities = 25/91 (27%), Positives = 41/91 (45%), Gaps = 9/91 (9%)
Query: 186 GAFAGGFAAAVTTPLDVAKTRIMLAKAG----SSTADGNVLSVLHGVWRSQGLAGLFAGV 241
G AG P+D+AKTR+ + G +S +D + +V RS+G G++ G
Sbjct: 15 GGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTV-----RSEGYFGMYRGA 69
Query: 242 FPRMAAISLGGFIFLGAYDRTHSLLLEVGRK 272
+ ++ I L A D L + G+K
Sbjct: 70 AVNLTLVTPEKAIKLAANDFFRHQLSKDGQK 100
>gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
Length = 311
Score = 83.6 bits (205), Expect = 2e-16
Identities = 81/286 (28%), Positives = 130/286 (45%), Gaps = 31/286 (10%)
Query: 9 ALVAGGVAGVSVDLILFPLDTIKTRLQ-----SPQGFNKAG----------GFHGIYAGV 53
A++AGG+AG I FP + +KT+LQ P + G G G+Y G+
Sbjct: 28 AILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGL 87
Query: 54 PSAAIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAA-SAGEVVACLIRVPSEVV 112
S GS P AA F +E++ + D+ L + +L AG A ++ P E +
Sbjct: 88 SSLLYGSIPKAAVRFGMFEFLSNHMR-DAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETI 146
Query: 113 KQR---AQVSASTR---TFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLK 166
K + Q S + + F I+ E+G++G Y+G +TVL++ ++F + SL+
Sbjct: 147 KVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLR 206
Query: 167 ALWSWRQDH---VVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLS 223
W +R D+ ++ + V GA AG + TPLDV KTR+ +A N
Sbjct: 207 N-W-YRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYR---NTWD 261
Query: 224 VLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAYDRTHSLLLEV 269
+ + +GL + G PR+ + L I YD LL +V
Sbjct: 262 CGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNKV 307
Score = 47.0 bits (110), Expect = 2e-05
Identities = 40/161 (24%), Positives = 67/161 (41%), Gaps = 8/161 (4%)
Query: 88 PMKHMLAASAGEVVACLIRVPSEVVKQRAQVSASTRTFQI------FSNILYEEGIQGLY 141
P K +LA + I P+E VK + Q+ + + + G+ GLY
Sbjct: 25 PGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLY 84
Query: 142 RGYKSTVLREIPFSLVQFPLWESLKALWSWRQDHVVDSWQSAVCGAFAG-GFAAAVTTPL 200
RG S + IP + V+F ++E L Q +DS + +CG AG A V P+
Sbjct: 85 RGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGR-LDSTRGLLCGLGAGVAEAVVVVCPM 143
Query: 201 DVAKTRIMLAKAGSSTADGNVLSVLHGVWRSQGLAGLFAGV 241
+ K + + + + + + R QGL G + G+
Sbjct: 144 ETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGL 184
>gi|149274643 solute carrier family 25, member 28 [Homo sapiens]
Length = 364
Score = 83.6 bits (205), Expect = 2e-16
Identities = 78/263 (29%), Positives = 118/263 (44%), Gaps = 33/263 (12%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQ---------------GFNKAGGFHGIYAGVP 54
+VAG VAG+ +++P+D +KTR+QS Q + G G+
Sbjct: 76 MVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMRGLN 135
Query: 55 SAAIGSFPNAAAFFITYEYVKWFLHADSSSYLTP--MKHMLAASAGEVVACL---IRVPS 109
A G+ P A +F YE +K L S + P H+ +AG V L P+
Sbjct: 136 VTATGAGPAHALYFACYEKLKKTL----SDVIHPGGNSHIANGAAGCVATLLHDAAMNPA 191
Query: 110 EVVKQRAQV--SASTRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKA 167
EVVKQR Q+ S R + EG YR Y + + +PF + F +E L+
Sbjct: 192 EVVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQE 251
Query: 168 LWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAK--AGSSTADGNV---L 222
++ ++ + S + GA AG AAA TTPLDV KT + + A +S G++
Sbjct: 252 HFNPQRRYNPSS--HVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMA 309
Query: 223 SVLHGVWRSQGLAGLFAGVFPRM 245
S V++ G+ F GV R+
Sbjct: 310 SAFRTVYQVGGVTAYFRGVQARV 332
Score = 45.8 bits (107), Expect = 4e-05
Identities = 43/190 (22%), Positives = 76/190 (40%), Gaps = 24/190 (12%)
Query: 7 VAALVAGGVAGVSVDLILFPLDTIKTRLQ---SP--------QGFNKAGGFHGIYAGVPS 55
+A AG VA + D + P + +K R+Q SP + + G Y +
Sbjct: 171 IANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTT 230
Query: 56 AAIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQR 115
+ P A F+TYE+++ H + P H+L+ + VA P +V K
Sbjct: 231 QLTMNVPFQAIHFMTYEFLQE--HFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTL 288
Query: 116 AQVSAS-----------TRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWES 164
S T F + G+ +RG ++ V+ +IP + + + ++E
Sbjct: 289 LNTQESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEF 348
Query: 165 LKALWSWRQD 174
K L + RQ+
Sbjct: 349 FKYLITKRQE 358
>gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]
Length = 301
Score = 82.8 bits (203), Expect = 3e-16
Identities = 79/275 (28%), Positives = 113/275 (41%), Gaps = 35/275 (12%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSP---------------QGFNKA---GGFHGIYA 51
L+AGG GV + + PLDT+K RLQ+ F K G G+Y
Sbjct: 14 LLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLYR 73
Query: 52 GVPSAAIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEV 111
G+ + IG P A F + K L+ + A V I P E
Sbjct: 74 GMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPGER 133
Query: 112 VKQRAQVSAS------TRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESL 165
+K Q+ AS T T + E GI+G+Y+G T++R++P S + F +E L
Sbjct: 134 IKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYEWL 193
Query: 166 KALWSWRQDHV--VDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLS 223
K +++ V + + + V G AG F AV P DV K+R A G
Sbjct: 194 KNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGK--YPNGFRD 251
Query: 224 VLHGVWRSQGLAGLFAG-------VFPRMAAISLG 251
VL + R +G+ L+ G FP AA LG
Sbjct: 252 VLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLG 286
Score = 61.2 bits (147), Expect = 9e-10
Identities = 48/203 (23%), Positives = 83/203 (40%), Gaps = 11/203 (5%)
Query: 80 ADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRAQVSASTR---------TFQIFSN 130
AD ++P+K++LA G V + P + VK R Q + TF F
Sbjct: 2 ADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRK 61
Query: 131 ILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQDHVVDSWQSAVCGAFAG 190
L+ EGI GLYRG + ++ P V F + K L + V+ Q G +G
Sbjct: 62 TLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSG 121
Query: 191 GFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGVWRSQGLAGLFAG-VFPRMAAIS 249
F + TP + K + + + + L +++ G+ G++ G V M +
Sbjct: 122 VFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVP 181
Query: 250 LGGFIFLGAYDRTHSLLLEVGRK 272
G F+ Y+ ++ G++
Sbjct: 182 ASGMYFM-TYEWLKNIFTPEGKR 203
Score = 53.5 bits (127), Expect = 2e-07
Identities = 43/181 (23%), Positives = 80/181 (44%), Gaps = 21/181 (11%)
Query: 12 AGGVAGVSVDLILFPLDTIKT--RLQSPQGFNKAGG-------------FHGIYAGVPSA 56
AG ++GV I+ P + IK ++Q+ G +K G GIY G
Sbjct: 116 AGMLSGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLT 175
Query: 57 AIGSFPNAAAFFITYEYVKWFLHADSS--SYLTPMKHMLAASAGEVVACLIRVPSEVVKQ 114
+ P + +F+TYE++K + S L+ + ++A + + +P +V+K
Sbjct: 176 LMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKS 235
Query: 115 RAQVSASTRTFQIFSNILYE----EGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWS 170
R Q + + F ++L E EG+ LY+G+ + ++R P + F +E +
Sbjct: 236 RFQTAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFLN 295
Query: 171 W 171
W
Sbjct: 296 W 296
>gi|157388925 solute carrier family 25, member 38 [Homo sapiens]
Length = 304
Score = 77.4 bits (189), Expect = 1e-14
Identities = 72/287 (25%), Positives = 123/287 (42%), Gaps = 30/287 (10%)
Query: 7 VAALVAGGVAGVSVDLILFPLDTIKTRLQSPQ----GFNKAG------------GFHGIY 50
+ A + G ++G L+ PLD +KTRLQ+ Q G + G G++
Sbjct: 28 IKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLW 87
Query: 51 AGVPSAAIGSFPNAAAFFIT-YEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPS 109
G+ + + P +F T Y ++FL T ++ ++ VA + P
Sbjct: 88 KGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPP---TALESVMLGVGSRSVAGVCMSPI 144
Query: 110 EVVKQRAQVS--ASTRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKA 167
V+K R + + +I + EG +GL+ G +T+LR+ PFS + + K
Sbjct: 145 TVIKTRYESGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKN 204
Query: 168 LWSWRQ-DHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLH 226
+ Q D + + CG FAG A+ VT P DV KT + L G +++
Sbjct: 205 IVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQLYPLKFQWI-GQAVTL-- 261
Query: 227 GVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAYDRTHSLLLEVGRKS 273
+++ GL G F G PR +L + Y+ ++ ++G KS
Sbjct: 262 -IFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYE---EMMAKMGLKS 304
>gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens]
Length = 301
Score = 77.0 bits (188), Expect = 2e-14
Identities = 70/286 (24%), Positives = 118/286 (41%), Gaps = 31/286 (10%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKA-----------GGFHGIYAGVPSAAI 58
L AG G + L P DT+K ++Q+ + GF G Y G A I
Sbjct: 13 LTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGFRGFYKGTSPALI 72
Query: 59 GSFPNAAAFFITYEY----VKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQ 114
+ + F+ Y + V+ D + L+ +++ A S A L+ P+E+VK
Sbjct: 73 ANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCPTELVKC 132
Query: 115 RAQVSASTRT-----------FQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWE 163
R Q T + + +IL ++G G Y G ST+LRE+P F +E
Sbjct: 133 RLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFFFFGGYE 192
Query: 164 SLKALW-SWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVL 222
++ + S R + + G G P+D K+RI + A +
Sbjct: 193 LSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQA--GFI 250
Query: 223 SVLHGVWRSQGLAGLFAGVFPRM-AAISLGGFIFLGAYDRTHSLLL 267
V +++G+ L++G+ P M A G +FL AY+ + L++
Sbjct: 251 RTFINVVKNEGITALYSGLKPTMIRAFPANGALFL-AYEYSRKLMM 295
Score = 47.8 bits (112), Expect = 1e-05
Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 13/97 (13%)
Query: 2 DRPGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKAGGF-------------HG 48
D G V +++GGV G+ + L ++P+D IK+R+Q K GF
Sbjct: 205 DELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITA 264
Query: 49 IYAGVPSAAIGSFPNAAAFFITYEYVKWFLHADSSSY 85
+Y+G+ I +FP A F+ YEY + + +Y
Sbjct: 265 LYSGLKPTMIRAFPANGALFLAYEYSRKLMMNQLEAY 301
>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
sapiens]
Length = 477
Score = 76.6 bits (187), Expect = 2e-14
Identities = 66/260 (25%), Positives = 106/260 (40%), Gaps = 24/260 (9%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQ----------GFN---KAGGFHGIYAGVPSA 56
L+AGG+AG PLD +K +Q GF K GG ++ G +
Sbjct: 198 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTN 257
Query: 57 AIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRA 116
I P A F YE K L + T + + + AG I P EV+K R
Sbjct: 258 VIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFI-YPMEVMKTRL 316
Query: 117 QVSASTRTFQIFS---NILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQ 173
V + + I+ IL EG+ Y+GY +L IP++ + ++E LK+ W
Sbjct: 317 AVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSY--WLD 374
Query: 174 DHVVDSWQSAV-----CGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGV 228
+ DS V CGA + + PL + +TR+ + N++ + +
Sbjct: 375 NFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRI 434
Query: 229 WRSQGLAGLFAGVFPRMAAI 248
+G+ GL+ G+ P +
Sbjct: 435 ISKEGIPGLYRGITPNFMKV 454
Score = 52.4 bits (124), Expect = 4e-07
Identities = 44/187 (23%), Positives = 75/187 (40%), Gaps = 29/187 (15%)
Query: 5 GFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKAGGFHGIY-------------- 50
G ++G +AG + ++P++ +KTRL K G + GIY
Sbjct: 287 GTFERFISGSMAGATAQTFIYPMEVMKTRL----AVGKTGQYSGIYDCAKKILKHEGLGA 342
Query: 51 --AGVPSAAIGSFPNAAAFFITYEYVK-WFLHADSSSYLTPMKHMLAASAGEVVAC--LI 105
G +G P A YE +K ++L + + P +L C L
Sbjct: 343 FYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLA 402
Query: 106 RVPSEVVKQRAQVSA------STRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQF 159
P +V+ R Q A +F I+ +EGI GLYRG ++ +P + +
Sbjct: 403 SYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISY 462
Query: 160 PLWESLK 166
++E++K
Sbjct: 463 VVYENMK 469
Score = 37.7 bits (86), Expect = 0.011
Identities = 24/93 (25%), Positives = 42/93 (45%), Gaps = 2/93 (2%)
Query: 180 WQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGVWRSQGLAGLFA 239
W+ + G AG + T PLD + +IM+ GS + N+ + + G+ L+
Sbjct: 195 WRQLLAGGIAGAVSRTSTAPLD--RLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWR 252
Query: 240 GVFPRMAAISLGGFIFLGAYDRTHSLLLEVGRK 272
G + I+ + AY++ LL E G+K
Sbjct: 253 GNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQK 285
Score = 31.6 bits (70), Expect = 0.78
Identities = 23/88 (26%), Positives = 36/88 (40%), Gaps = 17/88 (19%)
Query: 4 PGFVAALVAGGVAGVSVDLILFPLDTIKTRLQ-------SPQGFNKAG---------GFH 47
PG + L G ++ L +PL ++TR+Q SPQ N G G
Sbjct: 383 PGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQ-LNMVGLFRRIISKEGIP 441
Query: 48 GIYAGVPSAAIGSFPNAAAFFITYEYVK 75
G+Y G+ + P ++ YE +K
Sbjct: 442 GLYRGITPNFMKVLPAVGISYVVYENMK 469
>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
Length = 458
Score = 76.6 bits (187), Expect = 2e-14
Identities = 66/260 (25%), Positives = 106/260 (40%), Gaps = 24/260 (9%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQ----------GFN---KAGGFHGIYAGVPSA 56
L+AGG+AG PLD +K +Q GF K GG ++ G +
Sbjct: 179 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTN 238
Query: 57 AIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRA 116
I P A F YE K L + T + + + AG I P EV+K R
Sbjct: 239 VIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFI-YPMEVMKTRL 297
Query: 117 QVSASTRTFQIFS---NILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQ 173
V + + I+ IL EG+ Y+GY +L IP++ + ++E LK+ W
Sbjct: 298 AVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSY--WLD 355
Query: 174 DHVVDSWQSAV-----CGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGV 228
+ DS V CGA + + PL + +TR+ + N++ + +
Sbjct: 356 NFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRI 415
Query: 229 WRSQGLAGLFAGVFPRMAAI 248
+G+ GL+ G+ P +
Sbjct: 416 ISKEGIPGLYRGITPNFMKV 435
Score = 52.4 bits (124), Expect = 4e-07
Identities = 44/187 (23%), Positives = 75/187 (40%), Gaps = 29/187 (15%)
Query: 5 GFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKAGGFHGIY-------------- 50
G ++G +AG + ++P++ +KTRL K G + GIY
Sbjct: 268 GTFERFISGSMAGATAQTFIYPMEVMKTRL----AVGKTGQYSGIYDCAKKILKHEGLGA 323
Query: 51 --AGVPSAAIGSFPNAAAFFITYEYVK-WFLHADSSSYLTPMKHMLAASAGEVVAC--LI 105
G +G P A YE +K ++L + + P +L C L
Sbjct: 324 FYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLA 383
Query: 106 RVPSEVVKQRAQVSA------STRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQF 159
P +V+ R Q A +F I+ +EGI GLYRG ++ +P + +
Sbjct: 384 SYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISY 443
Query: 160 PLWESLK 166
++E++K
Sbjct: 444 VVYENMK 450
Score = 37.7 bits (86), Expect = 0.011
Identities = 24/93 (25%), Positives = 42/93 (45%), Gaps = 2/93 (2%)
Query: 180 WQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGVWRSQGLAGLFA 239
W+ + G AG + T PLD + +IM+ GS + N+ + + G+ L+
Sbjct: 176 WRQLLAGGIAGAVSRTSTAPLD--RLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWR 233
Query: 240 GVFPRMAAISLGGFIFLGAYDRTHSLLLEVGRK 272
G + I+ + AY++ LL E G+K
Sbjct: 234 GNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQK 266
Score = 31.6 bits (70), Expect = 0.78
Identities = 23/88 (26%), Positives = 36/88 (40%), Gaps = 17/88 (19%)
Query: 4 PGFVAALVAGGVAGVSVDLILFPLDTIKTRLQ-------SPQGFNKAG---------GFH 47
PG + L G ++ L +PL ++TR+Q SPQ N G G
Sbjct: 364 PGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQ-LNMVGLFRRIISKEGIP 422
Query: 48 GIYAGVPSAAIGSFPNAAAFFITYEYVK 75
G+Y G+ + P ++ YE +K
Sbjct: 423 GLYRGITPNFMKVLPAVGISYVVYENMK 450
>gi|239755176 PREDICTED: similar to solute carrier family 25, member
25 isoform 2 [Homo sapiens]
Length = 469
Score = 75.5 bits (184), Expect = 5e-14
Identities = 64/260 (24%), Positives = 112/260 (43%), Gaps = 24/260 (9%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQ----------GFN---KAGGFHGIYAGVPSA 56
LVAGG AG PLD +K +Q GF + GG ++ G
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 249
Query: 57 AIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRA 116
+ P +A F+ YE +K + +D + L + ++A S +A P EV+K R
Sbjct: 250 VLKIAPESAIKFMAYEQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 308
Query: 117 QVSASTRTFQIFS---NILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQ 173
+ + + + IL EG+ Y+GY +L IP++ + ++E+LK +W Q
Sbjct: 309 ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKN--AWLQ 366
Query: 174 DHVVDSWQSAV-----CGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGV 228
+ V+S V CG + + PL + +TR+ + + + S+ +
Sbjct: 367 HYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHI 426
Query: 229 WRSQGLAGLFAGVFPRMAAI 248
R++G GL+ G+ P +
Sbjct: 427 LRTEGAFGLYRGLAPNFMKV 446
Score = 29.3 bits (64), Expect = 3.9
Identities = 20/94 (21%), Positives = 35/94 (37%), Gaps = 15/94 (15%)
Query: 4 PGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFN---------------KAGGFHG 48
PG L G ++ L +PL ++TR+Q+ + G G
Sbjct: 375 PGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFG 434
Query: 49 IYAGVPSAAIGSFPNAAAFFITYEYVKWFLHADS 82
+Y G+ + P + ++ YE +K L S
Sbjct: 435 LYRGLAPNFMKVIPAVSISYVVYENLKITLGVQS 468
>gi|239755174 PREDICTED: similar to solute carrier family 25, member
25 isoform 1 [Homo sapiens]
Length = 503
Score = 75.5 bits (184), Expect = 5e-14
Identities = 64/260 (24%), Positives = 112/260 (43%), Gaps = 24/260 (9%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQ----------GFN---KAGGFHGIYAGVPSA 56
LVAGG AG PLD +K +Q GF + GG ++ G
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 283
Query: 57 AIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRA 116
+ P +A F+ YE +K + +D + L + ++A S +A P EV+K R
Sbjct: 284 VLKIAPESAIKFMAYEQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 342
Query: 117 QVSASTRTFQIFS---NILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQ 173
+ + + + IL EG+ Y+GY +L IP++ + ++E+LK +W Q
Sbjct: 343 ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKN--AWLQ 400
Query: 174 DHVVDSWQSAV-----CGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGV 228
+ V+S V CG + + PL + +TR+ + + + S+ +
Sbjct: 401 HYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHI 460
Query: 229 WRSQGLAGLFAGVFPRMAAI 248
R++G GL+ G+ P +
Sbjct: 461 LRTEGAFGLYRGLAPNFMKV 480
Score = 29.3 bits (64), Expect = 3.9
Identities = 20/94 (21%), Positives = 35/94 (37%), Gaps = 15/94 (15%)
Query: 4 PGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFN---------------KAGGFHG 48
PG L G ++ L +PL ++TR+Q+ + G G
Sbjct: 409 PGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFG 468
Query: 49 IYAGVPSAAIGSFPNAAAFFITYEYVKWFLHADS 82
+Y G+ + P + ++ YE +K L S
Sbjct: 469 LYRGLAPNFMKVIPAVSISYVVYENLKITLGVQS 502
>gi|13994341 solute carrier family 25 member 2 [Homo sapiens]
Length = 301
Score = 75.5 bits (184), Expect = 5e-14
Identities = 78/297 (26%), Positives = 128/297 (43%), Gaps = 37/297 (12%)
Query: 4 PGFVAA--LVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKA-----------GGFHGIY 50
PG AA L AG G + L P DTIK ++Q+ K G G Y
Sbjct: 5 PGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGLRGFY 64
Query: 51 AGVPSAAIGSFPNAAAFFITYEYVKWFLHA----DSSSYLTPMKHMLAASAGEVVACLIR 106
G A + + F+ Y + + F+ D + L+ ++ A S A L
Sbjct: 65 KGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALAL 124
Query: 107 VPSEVVKQRAQ----------VSASTRT-FQIFSNILYEEGIQGLYRGYKSTVLREIPFS 155
P+E+VK R Q ++ S T + + IL ++G G Y G ST+L+E+P
Sbjct: 125 CPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGY 184
Query: 156 LVQFPLWESLKALW-SWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGS 214
F +E ++ + S R + + G AG V P+D K+RI +
Sbjct: 185 FFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMYG 244
Query: 215 STAD--GNVLSVLHGVWRSQGLAGLFAGVFPRM-AAISLGGFIFLGAYDRTHSLLLE 268
A G +LSV+ R++G+ L++G+ M AI G +F+ AY+ + ++++
Sbjct: 245 KQAGFIGTLLSVV----RNEGIVALYSGLKATMIRAIPANGALFV-AYEYSRKMMMK 296
Score = 54.7 bits (130), Expect = 9e-08
Identities = 30/97 (30%), Positives = 50/97 (51%), Gaps = 13/97 (13%)
Query: 2 DRPGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKAGGFHG------------- 48
D G V +++GGVAG+ + L++FP+D IK+R+Q + K GF G
Sbjct: 205 DELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVA 264
Query: 49 IYAGVPSAAIGSFPNAAAFFITYEYVKWFLHADSSSY 85
+Y+G+ + I + P A F+ YEY + + +Y
Sbjct: 265 LYSGLKATMIRAIPANGALFVAYEYSRKMMMKQLEAY 301
>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
sapiens]
Length = 489
Score = 75.5 bits (184), Expect = 5e-14
Identities = 64/260 (24%), Positives = 112/260 (43%), Gaps = 24/260 (9%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQ----------GFN---KAGGFHGIYAGVPSA 56
LVAGG AG PLD +K +Q GF + GG ++ G
Sbjct: 210 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 269
Query: 57 AIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRA 116
+ P +A F+ YE +K + +D + L + ++A S +A P EV+K R
Sbjct: 270 VLKIAPESAIKFMAYEQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 328
Query: 117 QVSASTRTFQIFS---NILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQ 173
+ + + + IL EG+ Y+GY +L IP++ + ++E+LK +W Q
Sbjct: 329 ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKN--AWLQ 386
Query: 174 DHVVDSWQSAV-----CGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGV 228
+ V+S V CG + + PL + +TR+ + + + S+ +
Sbjct: 387 HYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHI 446
Query: 229 WRSQGLAGLFAGVFPRMAAI 248
R++G GL+ G+ P +
Sbjct: 447 LRTEGAFGLYRGLAPNFMKV 466
Score = 29.3 bits (64), Expect = 3.9
Identities = 20/94 (21%), Positives = 35/94 (37%), Gaps = 15/94 (15%)
Query: 4 PGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFN---------------KAGGFHG 48
PG L G ++ L +PL ++TR+Q+ + G G
Sbjct: 395 PGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFG 454
Query: 49 IYAGVPSAAIGSFPNAAAFFITYEYVKWFLHADS 82
+Y G+ + P + ++ YE +K L S
Sbjct: 455 LYRGLAPNFMKVIPAVSISYVVYENLKITLGVQS 488
>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
sapiens]
Length = 469
Score = 75.5 bits (184), Expect = 5e-14
Identities = 64/260 (24%), Positives = 112/260 (43%), Gaps = 24/260 (9%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQ----------GFN---KAGGFHGIYAGVPSA 56
LVAGG AG PLD +K +Q GF + GG ++ G
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 249
Query: 57 AIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRA 116
+ P +A F+ YE +K + +D + L + ++A S +A P EV+K R
Sbjct: 250 VLKIAPESAIKFMAYEQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 308
Query: 117 QVSASTRTFQIFS---NILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQ 173
+ + + + IL EG+ Y+GY +L IP++ + ++E+LK +W Q
Sbjct: 309 ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKN--AWLQ 366
Query: 174 DHVVDSWQSAV-----CGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGV 228
+ V+S V CG + + PL + +TR+ + + + S+ +
Sbjct: 367 HYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHI 426
Query: 229 WRSQGLAGLFAGVFPRMAAI 248
R++G GL+ G+ P +
Sbjct: 427 LRTEGAFGLYRGLAPNFMKV 446
Score = 29.3 bits (64), Expect = 3.9
Identities = 20/94 (21%), Positives = 35/94 (37%), Gaps = 15/94 (15%)
Query: 4 PGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFN---------------KAGGFHG 48
PG L G ++ L +PL ++TR+Q+ + G G
Sbjct: 375 PGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFG 434
Query: 49 IYAGVPSAAIGSFPNAAAFFITYEYVKWFLHADS 82
+Y G+ + P + ++ YE +K L S
Sbjct: 435 LYRGLAPNFMKVIPAVSISYVVYENLKITLGVQS 468
>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
Length = 303
Score = 75.5 bits (184), Expect = 5e-14
Identities = 77/265 (29%), Positives = 120/265 (45%), Gaps = 39/265 (14%)
Query: 12 AGGVAGVSVDLILFPLDTIKTRLQ-----SPQ---------GFNKAGGFHGIYAGVPSAA 57
AGGVAGV L+ P DT+K RLQ PQ K G+Y G+ S
Sbjct: 10 AGGVAGV---LVGHPFDTVKVRLQVQSVEKPQYRGTLHCFKSIIKQESVLGLYKGLGSPL 66
Query: 58 IG-SFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRA 116
+G +F NA F + ++ H +P+ LA +A + C+I P E+ K R
Sbjct: 67 MGLTFINALVFGVQGNTLRALGHD------SPLNQFLAGAAAGAIQCVICCPMELAKTRL 120
Query: 117 QV--SASTRTFQ----IFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESL-KALW 169
Q+ + RT++ + I EG++G+ RG ST+LRE P V F +++L +AL
Sbjct: 121 QLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLTYDALTRALG 180
Query: 170 SWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGVW 229
D ++ + + G +G + T P+DV K+R+ + +L +H +
Sbjct: 181 CEPGDRLLVP-KLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPRYRGILDCVHQSY 239
Query: 230 RSQ-------GLAGLFAGVFPRMAA 247
R++ GLA FP AA
Sbjct: 240 RAEGWRVFTRGLASTLLRAFPVNAA 264
Score = 57.4 bits (137), Expect = 1e-08
Identities = 50/185 (27%), Positives = 86/185 (46%), Gaps = 13/185 (7%)
Query: 93 LAASAGEVVACLIRVPSEVVKQRAQVSASTR-----TFQIFSNILYEEGIQGLYRGYKST 147
LA AG V L+ P + VK R QV + + T F +I+ +E + GLY+G S
Sbjct: 6 LAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQYRGTLHCFKSIIKQESVLGLYKGLGSP 65
Query: 148 VLREIPFSLVQFPLW-ESLKALWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTR 206
++ + + F + +L+AL D ++ + + GA AG + P+++AKTR
Sbjct: 66 LMGLTFINALVFGVQGNTLRALG---HDSPLNQF---LAGAAAGAIQCVICCPMELAKTR 119
Query: 207 IMLAKAGSSTADGNVLSVLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAYDR-THSL 265
+ L AG + L L ++ +GL G+ G+ + + ++ YD T +L
Sbjct: 120 LQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLTYDALTRAL 179
Query: 266 LLEVG 270
E G
Sbjct: 180 GCEPG 184
Score = 50.4 bits (119), Expect = 2e-06
Identities = 47/171 (27%), Positives = 68/171 (39%), Gaps = 23/171 (13%)
Query: 11 VAGGVAGVSVDLILFPLDTIKTRLQ----SPQGFNKAG-----------GFHGIYAGVPS 55
+AG AG +I P++ KTRLQ P K G G+ G+ S
Sbjct: 97 LAGAAAGAIQCVICCPMELAKTRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVS 156
Query: 56 AAIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQR 115
+ P+ +F+TY+ + L + L K +LA +V+ L P +VVK R
Sbjct: 157 TLLRETPSFGVYFLTYDALTRALGCEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSR 216
Query: 116 AQVSASTRTFQIFSNIL-------YEEGIQGLYRGYKSTVLREIPFSLVQF 159
Q R + IL EG + RG ST+LR P + F
Sbjct: 217 LQAD-GLRGAPRYRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATF 266
Score = 34.3 bits (77), Expect = 0.12
Identities = 25/90 (27%), Positives = 40/90 (44%), Gaps = 17/90 (18%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKAGGFHGIY----------------AGV 53
L+AGG +G+ L +P+D +K+RLQ+ G A + GI G+
Sbjct: 193 LLAGGTSGIVSWLSTYPVDVVKSRLQA-DGLRGAPRYRGILDCVHQSYRAEGWRVFTRGL 251
Query: 54 PSAAIGSFPNAAAFFITYEYVKWFLHADSS 83
S + +FP AA F T V + + +
Sbjct: 252 ASTLLRAFPVNAATFATVTVVLTYARGEEA 281
>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
sapiens]
Length = 366
Score = 75.5 bits (184), Expect = 5e-14
Identities = 64/260 (24%), Positives = 112/260 (43%), Gaps = 24/260 (9%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQ----------GFN---KAGGFHGIYAGVPSA 56
LVAGG AG PLD +K +Q GF + GG ++ G
Sbjct: 87 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 146
Query: 57 AIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRA 116
+ P +A F+ YE +K + +D + L + ++A S +A P EV+K R
Sbjct: 147 VLKIAPESAIKFMAYEQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 205
Query: 117 QVSASTRTFQIFS---NILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQ 173
+ + + + IL EG+ Y+GY +L IP++ + ++E+LK +W Q
Sbjct: 206 ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKN--AWLQ 263
Query: 174 DHVVDSWQSAV-----CGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGV 228
+ V+S V CG + + PL + +TR+ + + + S+ +
Sbjct: 264 HYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHI 323
Query: 229 WRSQGLAGLFAGVFPRMAAI 248
R++G GL+ G+ P +
Sbjct: 324 LRTEGAFGLYRGLAPNFMKV 343
Score = 29.3 bits (64), Expect = 3.9
Identities = 20/94 (21%), Positives = 35/94 (37%), Gaps = 15/94 (15%)
Query: 4 PGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFN---------------KAGGFHG 48
PG L G ++ L +PL ++TR+Q+ + G G
Sbjct: 272 PGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFG 331
Query: 49 IYAGVPSAAIGSFPNAAAFFITYEYVKWFLHADS 82
+Y G+ + P + ++ YE +K L S
Sbjct: 332 LYRGLAPNFMKVIPAVSISYVVYENLKITLGVQS 365
>gi|56699403 solute carrier family 25, member 25 isoform b [Homo
sapiens]
Length = 503
Score = 75.5 bits (184), Expect = 5e-14
Identities = 64/260 (24%), Positives = 112/260 (43%), Gaps = 24/260 (9%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQ----------GFN---KAGGFHGIYAGVPSA 56
LVAGG AG PLD +K +Q GF + GG ++ G
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 283
Query: 57 AIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRA 116
+ P +A F+ YE +K + +D + L + ++A S +A P EV+K R
Sbjct: 284 VLKIAPESAIKFMAYEQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 342
Query: 117 QVSASTRTFQIFS---NILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQ 173
+ + + + IL EG+ Y+GY +L IP++ + ++E+LK +W Q
Sbjct: 343 ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKN--AWLQ 400
Query: 174 DHVVDSWQSAV-----CGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGV 228
+ V+S V CG + + PL + +TR+ + + + S+ +
Sbjct: 401 HYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHI 460
Query: 229 WRSQGLAGLFAGVFPRMAAI 248
R++G GL+ G+ P +
Sbjct: 461 LRTEGAFGLYRGLAPNFMKV 480
Score = 29.3 bits (64), Expect = 3.9
Identities = 20/94 (21%), Positives = 35/94 (37%), Gaps = 15/94 (15%)
Query: 4 PGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFN---------------KAGGFHG 48
PG L G ++ L +PL ++TR+Q+ + G G
Sbjct: 409 PGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFG 468
Query: 49 IYAGVPSAAIGSFPNAAAFFITYEYVKWFLHADS 82
+Y G+ + P + ++ YE +K L S
Sbjct: 469 LYRGLAPNFMKVIPAVSISYVVYENLKITLGVQS 502
>gi|45237193 solute carrier family 25, member 44 isoform 1 [Homo
sapiens]
Length = 314
Score = 75.1 bits (183), Expect = 6e-14
Identities = 79/297 (26%), Positives = 125/297 (42%), Gaps = 58/297 (19%)
Query: 15 VAGVSVDLIL----FPLDTIKTRLQSPQGFN-------------KAGGFHGIYAGVPSAA 57
V GV++ +++ +P I+TRLQ +G + +A G G+Y G
Sbjct: 22 VFGVAMTMMIRVSVYPFTLIRTRLQVQKGKSLYHGTFDAFIKILRADGITGLYRGF---L 78
Query: 58 IGSFP--NAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQR 115
+ +F + + TYE + F+ AD S T +K ++A + +VA I VP +VV Q
Sbjct: 79 VNTFTLISGQCYVTTYELTRKFV-ADYSQSNT-VKSLVAGGSASLVAQSITVPIDVVSQH 136
Query: 116 AQ---------------------VSASTRTFQIFSNILYEEGIQGLYRGYKSTVLREIPF 154
V A +T I IL +G++G YRGY +++L IP
Sbjct: 137 LMMQRKGEKMGRFQVRGNPEGQGVVAFGQTKDIIRQILQADGLRGFYRGYVASLLTYIPN 196
Query: 155 SLVQFPLW----ESLKALWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLA 210
S V +P + E L L H+V AV G A A+ +T P+DV +TR+ +
Sbjct: 197 SAVWWPFYHFYAEQLSYLCPKECPHIV---FQAVSGPLAAATASILTNPMDVIRTRVQVE 253
Query: 211 KAGSSTADGNVLSVLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAYDRTHSLLL 267
S L G W GL G+ R+ + + + + Y+ L L
Sbjct: 254 GKNSIILTFRQLMAEEGPW------GLMKGLSARIISATPSTIVIVVGYESLKKLSL 304
Score = 30.4 bits (67), Expect = 1.7
Identities = 21/82 (25%), Positives = 37/82 (45%), Gaps = 11/82 (13%)
Query: 4 PGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNK----------AGGFHGIYAGV 53
P V V+G +A + ++ P+D I+TR+Q +G N G G+ G+
Sbjct: 220 PHIVFQAVSGPLAAATASILTNPMDVIRTRVQ-VEGKNSIILTFRQLMAEEGPWGLMKGL 278
Query: 54 PSAAIGSFPNAAAFFITYEYVK 75
+ I + P+ + YE +K
Sbjct: 279 SARIISATPSTIVIVVGYESLK 300
>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
Length = 291
Score = 73.9 bits (180), Expect = 1e-13
Identities = 69/284 (24%), Positives = 115/284 (40%), Gaps = 33/284 (11%)
Query: 11 VAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKA--------------------GGFHGIY 50
V GG+A ++ + FP+D KTRLQ N A G +Y
Sbjct: 10 VYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLKALY 69
Query: 51 AGVPSAAIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSE 110
+G+ A + TY+ +K P+ + +G V++ I P++
Sbjct: 70 SGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDETLPINVICGILSG-VISSTIANPTD 128
Query: 111 VVKQRAQVSAST---RTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLK- 166
V+K R Q ++T F NI +EG +GL++G T R V+ P+++ K
Sbjct: 129 VLKIRMQAQSNTIQGGMIGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVGVELPVYDITKK 188
Query: 167 --ALWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIM---LAKAGSSTADGNV 221
L D V + S+ AG A + P+DV +TR+M + + G +
Sbjct: 189 HLILSGLMGDTVYTHFLSSFTCGLAGALA---SNPVDVVRTRMMNQRVLRDGRCSGYTGT 245
Query: 222 LSVLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAYDRTHSL 265
L L W+++G L+ G +P + IF Y++ L
Sbjct: 246 LDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKKL 289
Score = 61.6 bits (148), Expect = 7e-10
Identities = 49/178 (27%), Positives = 85/178 (47%), Gaps = 23/178 (12%)
Query: 108 PSEVVKQRAQVSASTRTFQIFSNILY------------EEGIQGLYRGYKSTVLREIPFS 155
P ++ K R Q+ T + F I Y EEG++ LY G +LR+ +
Sbjct: 25 PIDLTKTRLQIQGQTNDAK-FKEIRYRGMLHALVRIGREEGLKALYSGIAPAMLRQASYG 83
Query: 156 LVQFPLWESLKALWSWR-QDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGS 214
++ ++SLK L+ R +D + + +CG +G ++ + P DV K R+ +A S
Sbjct: 84 TIKIGTYQSLKRLFIERPEDETLPI--NVICGILSGVISSTIANPTDVLKIRM---QAQS 138
Query: 215 STADGNVLSVLHGVWRSQGLAGLFAGV--FPRMAAISLGGFIFLGAYDRTHSLLLEVG 270
+T G ++ +++ +G GL+ GV + AAI +G + L YD T L+ G
Sbjct: 139 NTIQGGMIGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVG--VELPVYDITKKHLILSG 194
Score = 41.6 bits (96), Expect = 8e-04
Identities = 42/180 (23%), Positives = 67/180 (37%), Gaps = 21/180 (11%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKAG------------GFHGIYAGVPSAA 57
++ G ++GV I P D +K R+Q+ + G G G++ GV A
Sbjct: 110 VICGILSGVISSTIANPTDVLKIRMQAQSNTIQGGMIGNFMNIYQQEGTRGLWKGVSLTA 169
Query: 58 IGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQR-- 115
+ Y+ K L T H L++ + L P +VV+ R
Sbjct: 170 QRAAIVVGVELPVYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMM 229
Query: 116 -------AQVSASTRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKAL 168
+ S T T EG LY+G+ LR P++++ F +E LK L
Sbjct: 230 NQRVLRDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKKL 289
Score = 40.4 bits (93), Expect = 0.002
Identities = 28/98 (28%), Positives = 43/98 (43%), Gaps = 11/98 (11%)
Query: 179 SWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADG--------NVLSVLHGVWR 230
+W+ V G A A T P+D+ KTR+ + T D +L L + R
Sbjct: 5 NWKPFVYGGLASITAECGTFPIDLTKTRLQIQ---GQTNDAKFKEIRYRGMLHALVRIGR 61
Query: 231 SQGLAGLFAGVFPRMAAISLGGFIFLGAYDRTHSLLLE 268
+GL L++G+ P M + G I +G Y L +E
Sbjct: 62 EEGLKALYSGIAPAMLRQASYGTIKIGTYQSLKRLFIE 99
>gi|11225256 uncoupling protein 1 [Homo sapiens]
Length = 307
Score = 73.9 bits (180), Expect = 1e-13
Identities = 68/285 (23%), Positives = 119/285 (41%), Gaps = 31/285 (10%)
Query: 4 PGFVAALVAGGVAGVSVDLILFPLDTIKTRLQ------------------SPQGFNKAGG 45
P L + G+A D+I FPLDT K RLQ + K G
Sbjct: 11 PTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEG 70
Query: 46 FHGIYAGVPSAAIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLI 105
+Y+G+P+ +A+ Y+ V+ FL A + + +LA VA I
Sbjct: 71 RMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFI 130
Query: 106 RVPSEVVKQRAQVSAS--------TRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLV 157
P+EVVK R Q + T T+ + I EG+ GL++G ++R + +
Sbjct: 131 GQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCT 190
Query: 158 QFPLWESLKALWSWRQDHVVDSWQSAVCGAFAGGF-AAAVTTPLDVAKTRIMLAKAGSST 216
+ ++ +K + + + + D + A GF A A+++P+DV KTR + + G
Sbjct: 191 ELVTYDLMKEAFV-KNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYK 249
Query: 217 ADGNVLSVLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAYDR 261
+V + V+ ++G F G+ P + I +++
Sbjct: 250 ---SVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQ 291
>gi|21314739 solute carrier family 25, member 32 [Homo sapiens]
Length = 315
Score = 73.9 bits (180), Expect = 1e-13
Identities = 73/294 (24%), Positives = 118/294 (40%), Gaps = 37/294 (12%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQGFN----------------KAGGFHGIYAGV 53
L+AG GV +L L PLD +K R G K G G+Y GV
Sbjct: 26 LIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQGV 85
Query: 54 PSAAIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHML-AASAGEVVACLIRVPSEVV 112
G+ + +F Y +K + + L ++++ AA AG + C+ P V
Sbjct: 86 TPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITN-PLWVT 144
Query: 113 KQR------AQVSASTR----TFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLW 162
K R A V++ R F I EG++GLY+G+ L +QF +
Sbjct: 145 KTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPG-LFGTSHGALQFMAY 203
Query: 163 ESLKALWSWRQDHVVDSWQSAV----CGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTAD 218
E LK ++ + + ++ S V A + FA A T P V + R+
Sbjct: 204 ELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQ----DQHMFY 259
Query: 219 GNVLSVLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAYDRTHSLLLEVGRK 272
V+ V+ WR +G+ G + G+ P + ++ I Y+ LL++ K
Sbjct: 260 SGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFLLDLREK 313
>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
Length = 468
Score = 71.6 bits (174), Expect = 7e-13
Identities = 63/260 (24%), Positives = 105/260 (40%), Gaps = 24/260 (9%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQ-------------SPQGFNKAGGFHGIYAGVPSA 56
LVAG VAG PLD +K +Q + GG ++ G
Sbjct: 189 LVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNILGGLRSMVLEGGIRSLWRGNGIN 248
Query: 57 AIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRA 116
+ P +A F+ YE +K + + L + +A S A I P EV+K R
Sbjct: 249 VLKIAPESAIKFMAYEQIKRAILGQQET-LHVQERFVAGSLAGATAQTIIYPMEVLKTRL 307
Query: 117 QVSASTRTFQIFS---NILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQ 173
+ + + + IL EG + YRGY VL IP++ + ++E+LK W +
Sbjct: 308 TLRRTGQYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETLKNWWLQQY 367
Query: 174 DHVVDSWQSAV-----CGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVLSVLHGV 228
H DS + CG + + PL + +TR+ + ++L +L +
Sbjct: 368 SH--DSADPGILVLLACGTISSTCGQIASYPLALVRTRMQAQASIEGGPQLSMLGLLRHI 425
Query: 229 WRSQGLAGLFAGVFPRMAAI 248
+G+ GL+ G+ P +
Sbjct: 426 LSQEGMRGLYRGIAPNFMKV 445
Score = 58.5 bits (140), Expect = 6e-09
Identities = 47/177 (26%), Positives = 75/177 (42%), Gaps = 21/177 (11%)
Query: 11 VAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKAG------------GFHGIYAGVPSAAI 58
VAG +AG + I++P++ +KTRL + G G Y G +
Sbjct: 284 VAGSLAGATAQTIIYPMEVLKTRLTLRRTGQYKGLLDCARRILEREGPRAFYRGYLPNVL 343
Query: 59 GSFPNAAAFFITYEYVK-WFLHADSSSYLTPMKHMLAASAGEVVAC--LIRVPSEVVKQR 115
G P A YE +K W+L S P +L A C + P +V+ R
Sbjct: 344 GIIPYAGIDLAVYETLKNWWLQQYSHDSADPGILVLLACGTISSTCGQIASYPLALVRTR 403
Query: 116 AQVSASTR------TFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLK 166
Q AS + +IL +EG++GLYRG ++ IP + + ++E++K
Sbjct: 404 MQAQASIEGGPQLSMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMK 460
Score = 32.7 bits (73), Expect = 0.35
Identities = 27/110 (24%), Positives = 44/110 (40%), Gaps = 12/110 (10%)
Query: 158 QFPLWESLKALWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTA 217
+F E L +W W+ V GA AG + T PLD + ++ + S T
Sbjct: 174 EFSKQEKLTGMW----------WKQLVAGAVAGAVSRTGTAPLD--RLKVFMQVHASKTN 221
Query: 218 DGNVLSVLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAYDRTHSLLL 267
N+L L + G+ L+ G + I+ I AY++ +L
Sbjct: 222 RLNILGGLRSMVLEGGIRSLWRGNGINVLKIAPESAIKFMAYEQIKRAIL 271
Score = 31.2 bits (69), Expect = 1.0
Identities = 19/94 (20%), Positives = 35/94 (37%), Gaps = 15/94 (15%)
Query: 4 PGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFN---------------KAGGFHG 48
PG + L G ++ + +PL ++TR+Q+ G G
Sbjct: 374 PGILVLLACGTISSTCGQIASYPLALVRTRMQAQASIEGGPQLSMLGLLRHILSQEGMRG 433
Query: 49 IYAGVPSAAIGSFPNAAAFFITYEYVKWFLHADS 82
+Y G+ + P + ++ YE +K L S
Sbjct: 434 LYRGIAPNFMKVIPAVSISYVVYENMKQALGVTS 467
>gi|7706306 solute carrier family 25, member 39 isoform b [Homo
sapiens]
Length = 351
Score = 71.2 bits (173), Expect = 9e-13
Identities = 62/227 (27%), Positives = 100/227 (44%), Gaps = 14/227 (6%)
Query: 45 GFHGIYAGVPSAAIGSFPNAAAFFITYEYVKWFL--HADSSSYLTPMKHMLAASAGEVVA 102
G +++G+P+ + + P A +F Y+ +K FL A +S PM A G V
Sbjct: 111 GTRTLWSGLPATLVMTVPATAIYFTAYDQLKAFLCGRALTSDLYAPMVAGALARLGTVT- 169
Query: 103 CLIRVPSEVVKQRAQVS-ASTRTF-QIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFP 160
+ P E+++ + Q S R + + G + L+ G+ T LR++PFS + +
Sbjct: 170 --VISPLELMRTKLQAQHVSYRELGACVRTAVAQGGWRSLWLGWGPTALRDVPFSALYWF 227
Query: 161 LWESLKA-LWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADG 219
+E +K+ L +R S V G +G AA +T P DV KT+ +A
Sbjct: 228 NYELVKSWLNGFRPKDQTSVGMSFVAGGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRV 287
Query: 220 NVLSV------LHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAYD 260
N L V L + G GLFAG PR+ + I + Y+
Sbjct: 288 NPLHVDSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIMISTYE 334
Score = 54.7 bits (130), Expect = 9e-08
Identities = 53/223 (23%), Positives = 88/223 (39%), Gaps = 32/223 (14%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKAGGFHGIYAGVPSAAIGSFPNAAAFFI 69
+VA G V L + PLD +K RLQS + PS A P++ + +
Sbjct: 15 MVASGTGAVVTSLFMTPLDVVKVRLQSQR---------------PSMASELMPSSRLWSL 59
Query: 70 TYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRAQVSASTRTFQIFS 129
+Y K L+ + ++ + G A + P+ T T F
Sbjct: 60 SYTKWKCLLYCNGV-----LEPLYLCPNGARCATWFQDPTRF----------TGTMDAFV 104
Query: 130 NILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQDHVVDSWQSAVCGAFA 189
I+ EG + L+ G +T++ +P + + F ++ LKA R D + V GA A
Sbjct: 105 KIVRHEGTRTLWSGLPATLVMTVPATAIYFTAYDQLKAFLCGRA-LTSDLYAPMVAGALA 163
Query: 190 GGFAAAVTTPLDVAKTRIMLAKAGSSTADGNV-LSVLHGVWRS 231
V +PL++ +T++ V +V G WRS
Sbjct: 164 RLGTVTVISPLELMRTKLQAQHVSYRELGACVRTAVAQGGWRS 206
Score = 53.5 bits (127), Expect = 2e-07
Identities = 41/186 (22%), Positives = 81/186 (43%), Gaps = 24/186 (12%)
Query: 8 AALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNK-----------AGGFHGIYAGVPSA 56
A +VAG +A + ++ PL+ ++T+LQ+ + GG+ ++ G
Sbjct: 155 APMVAGALARLGTVTVISPLELMRTKLQAQHVSYRELGACVRTAVAQGGWRSLWLGWGPT 214
Query: 57 AIGSFPNAAAFFITYEYVKWFLHADSSSYLTPM-KHMLAASAGEVVACLIRVPSEVVKQR 115
A+ P +A ++ YE VK +L+ T + +A VA ++ +P +VVK +
Sbjct: 215 ALRDVPFSALYWFNYELVKSWLNGFRPKDQTSVGMSFVAGGISGTVAAVLTLPFDVVKTQ 274
Query: 116 AQVSAST------------RTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWE 163
QV+ T+ + I E G +GL+ G+ +++ P + +E
Sbjct: 275 RQVALGAMEAVRVNPLHVDSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIMISTYE 334
Query: 164 SLKALW 169
K+ +
Sbjct: 335 FGKSFF 340
Score = 36.2 bits (82), Expect = 0.032
Identities = 25/97 (25%), Positives = 39/97 (40%), Gaps = 21/97 (21%)
Query: 2 DRPGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKA------------------ 43
D+ + VAGG++G ++ P D +KT+ Q G +A
Sbjct: 243 DQTSVGMSFVAGGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRVNPLHVDSTWLLLRRI 302
Query: 44 ---GGFHGIYAGVPSAAIGSFPNAAAFFITYEYVKWF 77
G G++AG I + P+ A TYE+ K F
Sbjct: 303 RAESGTKGLFAGFLPRIIKAAPSCAIMISTYEFGKSF 339
>gi|219555665 solute carrier family 25, member 39 isoform a [Homo
sapiens]
Length = 359
Score = 71.2 bits (173), Expect = 9e-13
Identities = 62/227 (27%), Positives = 100/227 (44%), Gaps = 14/227 (6%)
Query: 45 GFHGIYAGVPSAAIGSFPNAAAFFITYEYVKWFL--HADSSSYLTPMKHMLAASAGEVVA 102
G +++G+P+ + + P A +F Y+ +K FL A +S PM A G V
Sbjct: 119 GTRTLWSGLPATLVMTVPATAIYFTAYDQLKAFLCGRALTSDLYAPMVAGALARLGTVT- 177
Query: 103 CLIRVPSEVVKQRAQVS-ASTRTF-QIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFP 160
+ P E+++ + Q S R + + G + L+ G+ T LR++PFS + +
Sbjct: 178 --VISPLELMRTKLQAQHVSYRELGACVRTAVAQGGWRSLWLGWGPTALRDVPFSALYWF 235
Query: 161 LWESLKA-LWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADG 219
+E +K+ L +R S V G +G AA +T P DV KT+ +A
Sbjct: 236 NYELVKSWLNGFRPKDQTSVGMSFVAGGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRV 295
Query: 220 NVLSV------LHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAYD 260
N L V L + G GLFAG PR+ + I + Y+
Sbjct: 296 NPLHVDSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIMISTYE 342
Score = 53.5 bits (127), Expect = 2e-07
Identities = 41/186 (22%), Positives = 81/186 (43%), Gaps = 24/186 (12%)
Query: 8 AALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNK-----------AGGFHGIYAGVPSA 56
A +VAG +A + ++ PL+ ++T+LQ+ + GG+ ++ G
Sbjct: 163 APMVAGALARLGTVTVISPLELMRTKLQAQHVSYRELGACVRTAVAQGGWRSLWLGWGPT 222
Query: 57 AIGSFPNAAAFFITYEYVKWFLHADSSSYLTPM-KHMLAASAGEVVACLIRVPSEVVKQR 115
A+ P +A ++ YE VK +L+ T + +A VA ++ +P +VVK +
Sbjct: 223 ALRDVPFSALYWFNYELVKSWLNGFRPKDQTSVGMSFVAGGISGTVAAVLTLPFDVVKTQ 282
Query: 116 AQVSAST------------RTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWE 163
QV+ T+ + I E G +GL+ G+ +++ P + +E
Sbjct: 283 RQVALGAMEAVRVNPLHVDSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIMISTYE 342
Query: 164 SLKALW 169
K+ +
Sbjct: 343 FGKSFF 348
Score = 52.4 bits (124), Expect = 4e-07
Identities = 53/226 (23%), Positives = 88/226 (38%), Gaps = 30/226 (13%)
Query: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKAGGFHGIYAGVPSAAIGSFPNAAAFFI 69
+VA G V L + PLD +K RLQS + PS A P++ + +
Sbjct: 15 MVASGTGAVVTSLFMTPLDVVKVRLQSQR---------------PSMASELMPSSRLWSL 59
Query: 70 TYEYVKWFLHADSSSYLT---PMKHMLAASAGEVVACLIRVPSEVVKQRAQVSASTRTFQ 126
+Y + L + L ++ + G A + P+ T T
Sbjct: 60 SYTKLPSSLQSTGKCLLYCNGVLEPLYLCPNGARCATWFQDPTRF----------TGTMD 109
Query: 127 IFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQDHVVDSWQSAVCG 186
F I+ EG + L+ G +T++ +P + + F ++ LKA R D + V G
Sbjct: 110 AFVKIVRHEGTRTLWSGLPATLVMTVPATAIYFTAYDQLKAFLCGRA-LTSDLYAPMVAG 168
Query: 187 AFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNV-LSVLHGVWRS 231
A A V +PL++ +T++ V +V G WRS
Sbjct: 169 ALARLGTVTVISPLELMRTKLQAQHVSYRELGACVRTAVAQGGWRS 214
Score = 36.2 bits (82), Expect = 0.032
Identities = 25/97 (25%), Positives = 39/97 (40%), Gaps = 21/97 (21%)
Query: 2 DRPGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKA------------------ 43
D+ + VAGG++G ++ P D +KT+ Q G +A
Sbjct: 251 DQTSVGMSFVAGGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRVNPLHVDSTWLLLRRI 310
Query: 44 ---GGFHGIYAGVPSAAIGSFPNAAAFFITYEYVKWF 77
G G++AG I + P+ A TYE+ K F
Sbjct: 311 RAESGTKGLFAGFLPRIIKAAPSCAIMISTYEFGKSF 347
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.136 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,532,343
Number of Sequences: 37866
Number of extensions: 376208
Number of successful extensions: 1180
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 678
Number of HSP's gapped (non-prelim): 216
length of query: 274
length of database: 18,247,518
effective HSP length: 101
effective length of query: 173
effective length of database: 14,423,052
effective search space: 2495187996
effective search space used: 2495187996
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.