Guide to the Human Genome
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Search of human proteins with 224500884

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|224500884 hypothetical protein LOC339541 [Homo sapiens]
         (440 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|224500884 hypothetical protein LOC339541 [Homo sapiens]            840   0.0  
gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens]       34   0.30 
gi|33589814 zyg-11 homolog B (C. elegans)-like [Homo sapiens]          33   0.39 
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]     32   1.1  
gi|145386578 torsin family 2, member A isoform a [Homo sapiens]        31   2.0  
gi|4507831 Unc-51-like kinase 1 [Homo sapiens]                         31   2.6  
gi|227430303 CD109 antigen isoform 3 precursor [Homo sapiens]          30   3.3  
gi|227430301 CD109 antigen isoform 2 precursor [Homo sapiens]          30   3.3  
gi|115529484 CD109 antigen isoform 1 precursor [Homo sapiens]          30   3.3  
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi...    30   3.3  
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi...    30   3.3  
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ...    30   5.7  
gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ...    30   5.7  
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]      30   5.7  
gi|227498241 actin-like 8 [Homo sapiens]                               29   7.4  
gi|224465231 solute carrier family 9, member 11 [Homo sapiens]         29   7.4  
gi|112420977 TBP-interacting protein isoform 2 [Homo sapiens]          29   9.7  

>gi|224500884 hypothetical protein LOC339541 [Homo sapiens]
          Length = 440

 Score =  840 bits (2170), Expect = 0.0
 Identities = 440/440 (100%), Positives = 440/440 (100%)

Query: 1   MTSIKEQAAISRLLSFLQEWDNAGKVARSHILDKFIETNQGKTAPELEQEFSQGASLFLV 60
           MTSIKEQAAISRLLSFLQEWDNAGKVARSHILDKFIETNQGKTAPELEQEFSQGASLFLV
Sbjct: 1   MTSIKEQAAISRLLSFLQEWDNAGKVARSHILDKFIETNQGKTAPELEQEFSQGASLFLV 60

Query: 61  RLTTSLRITYMTDSCLEKLLRSIGIFLSAVSSNRYLIEFLEVGGVLTLLEILGLEKIKEE 120
           RLTTSLRITYMTDSCLEKLLRSIGIFLSAVSSNRYLIEFLEVGGVLTLLEILGLEKIKEE
Sbjct: 61  RLTTSLRITYMTDSCLEKLLRSIGIFLSAVSSNRYLIEFLEVGGVLTLLEILGLEKIKEE 120

Query: 121 AKKESVKLLQVIANSGRTYKELICESYGVRSIAEFLAKSKSEETQEEVQVLLDSLVHGNP 180
           AKKESVKLLQVIANSGRTYKELICESYGVRSIAEFLAKSKSEETQEEVQVLLDSLVHGNP
Sbjct: 121 AKKESVKLLQVIANSGRTYKELICESYGVRSIAEFLAKSKSEETQEEVQVLLDSLVHGNP 180

Query: 181 KYQNQVYKGLIALLPCESPKAQQLSLQTLRTAQPIIGTTHPSIVDCVLKVLGTMHLEVQY 240
           KYQNQVYKGLIALLPCESPKAQQLSLQTLRTAQPIIGTTHPSIVDCVLKVLGTMHLEVQY
Sbjct: 181 KYQNQVYKGLIALLPCESPKAQQLSLQTLRTAQPIIGTTHPSIVDCVLKVLGTMHLEVQY 240

Query: 241 EAIELIKDLVGYDVRQALLKGLVALLIPSVKEISKLQAKILSDPSVLQLTPSLPMFLQQA 300
           EAIELIKDLVGYDVRQALLKGLVALLIPSVKEISKLQAKILSDPSVLQLTPSLPMFLQQA
Sbjct: 241 EAIELIKDLVGYDVRQALLKGLVALLIPSVKEISKLQAKILSDPSVLQLTPSLPMFLQQA 300

Query: 301 AAAKAIGVLARNDMSIAEELLYLRVVRGLMAAMGNTDHSNSQRLASLTLECFVQMFPLVA 360
           AAAKAIGVLARNDMSIAEELLYLRVVRGLMAAMGNTDHSNSQRLASLTLECFVQMFPLVA
Sbjct: 301 AAAKAIGVLARNDMSIAEELLYLRVVRGLMAAMGNTDHSNSQRLASLTLECFVQMFPLVA 360

Query: 361 EHVRKCMGEELYQLFLSNAEDLYMKIDSIQADILAANTVNVTKALCLHGSSYSMNTLYGS 420
           EHVRKCMGEELYQLFLSNAEDLYMKIDSIQADILAANTVNVTKALCLHGSSYSMNTLYGS
Sbjct: 361 EHVRKCMGEELYQLFLSNAEDLYMKIDSIQADILAANTVNVTKALCLHGSSYSMNTLYGS 420

Query: 421 RDSAQMAYLTHFEEDVESKE 440
           RDSAQMAYLTHFEEDVESKE
Sbjct: 421 RDSAQMAYLTHFEEDVESKE 440


>gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens]
          Length = 2179

 Score = 33.9 bits (76), Expect = 0.30
 Identities = 26/99 (26%), Positives = 45/99 (45%), Gaps = 14/99 (14%)

Query: 194 LPCESPKAQQLSLQTLRTAQPIIGTTHPSIVDCVLKVLGTMHLEVQYEAIELIKDLVGYD 253
           +P + PKA  +++  L   Q I+ +   S++DC              E  E  K L+ ++
Sbjct: 290 IPNQIPKAAFMAVFILEVDQFILTSLTTSVLDC--------------EEDETPKPLLVFN 335

Query: 254 VRQALLKGLVALLIPSVKEISKLQAKILSDPSVLQLTPS 292
           + +A L+G V  L+   + IS    K LSD  +    P+
Sbjct: 336 ITKAPLQGYVTHLLDHTRPISSFTWKDLSDMQIAYQPPN 374


>gi|33589814 zyg-11 homolog B (C. elegans)-like [Homo sapiens]
          Length = 766

 Score = 33.5 bits (75), Expect = 0.39
 Identities = 25/108 (23%), Positives = 54/108 (50%), Gaps = 3/108 (2%)

Query: 78  KLLRSIGIFLSAVSSNRYLIEFLEVGGVLTLLEILGLEKIKEEAKKESVKLLQVIANSGR 137
           +LLR++ + ++A+  ++Y    ++V G   L  +   E   E++ K   +++QV+ N   
Sbjct: 389 QLLRALKLVITALKCHKY-DRNIQVTGSAALFYLTNSEYRSEQSVKLRRQVIQVVLNGME 447

Query: 138 TYKELICESYGVRSIAEFLAKSKSEETQEEVQVLLDSLVHGNPKYQNQ 185
           +Y+E+  +     ++  F    + E     V  LL S++  NP  Q++
Sbjct: 448 SYQEVTVQRNCCLTLCNFSIPEELEFQYRRVNELLLSIL--NPTRQDE 493


>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
          Length = 1651

 Score = 32.0 bits (71), Expect = 1.1
 Identities = 49/225 (21%), Positives = 86/225 (38%), Gaps = 29/225 (12%)

Query: 40  QGKTAPELEQ-EFSQGASLFLVRLTTSLRITYMTDSCLEKLLRS-IGIFLSAVSSNRYLI 97
           QG+ +P   + + S+ ASL  +  + +L +T   +   E LL + I +F        +L+
Sbjct: 222 QGRWSPSFSRVQLSEEASLHYIHSSETLTLTL--NHTAEHLLEADIKLFRKYFWDRAFLV 279

Query: 98  EFLEV------------GGVLTLLEILGLEKIKEEAKKESVKLLQVIANSGRTYKELICE 145
           +  E              G  T  EI      +  A+KE +K ++ +      +++    
Sbjct: 280 KAFEPEARPEERTAMPSSGAETEEEIKNSVSSRSAAEKEDIKRVKSLVVQHNEHEDQ--H 337

Query: 146 SYGVRSIAEFLAKSKSEETQEEVQVLLDSLVHGNPKYQNQV-----------YKGLIALL 194
           S  +    + L KSK   T      L D L  G+  Y N +           Y  +  + 
Sbjct: 338 SLDLDRSFDILKKSKPPSTLLAAGRLSDMLNGGDEVYANCMVIDQVGDLDISYINIEGIT 397

Query: 195 PCESPKAQQLSLQTLRTAQPIIGTTHPSIVDCVLKVLGTMHLEVQ 239
              SP+++  +L    +   +   T PS+      V GT H E Q
Sbjct: 398 ATTSPESRGCTLWPQSSKHTLPTETSPSVYPLSENVEGTAHTEAQ 442


>gi|145386578 torsin family 2, member A isoform a [Homo sapiens]
          Length = 321

 Score = 31.2 bits (69), Expect = 2.0
 Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 2/58 (3%)

Query: 331 AAMGNTDH--SNSQRLASLTLECFVQMFPLVAEHVRKCMGEELYQLFLSNAEDLYMKI 386
           A + N  H  SNS  +    L+  V   PL   HVR C+  EL QL L   +++   +
Sbjct: 234 AVLDNPHHGFSNSGIMEERLLDAVVPFLPLQRHHVRHCVLNELAQLGLEPRDEVVQAV 291


>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
          Length = 1050

 Score = 30.8 bits (68), Expect = 2.6
 Identities = 45/179 (25%), Positives = 81/179 (45%), Gaps = 17/179 (9%)

Query: 238 VQYEAIELIKDLVGYDVRQALLKGL--VALLIPSVKEISKLQAKILSDPSVLQLTPSLPM 295
           V +EA +L ++ +       +L+GL    L +  V EI+ L+       S  +       
Sbjct: 823 VTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKG------SASEAAGGPEY 876

Query: 296 FLQQAAAAKAIGVLARNDMSIAEEL-LYLRVVR----GLMAAMGNTDHSNSQRLASLTLE 350
            LQ++  A  I +L+R +   AE+L LYL+V      GL +A+     +    L+S   +
Sbjct: 877 QLQESVVADQISLLSR-EWGFAEQLVLYLKVAELLSSGLQSAIDQI-RAGKLCLSSTVKQ 934

Query: 351 CFVQMFPLVAEHVRKCMGEEL-YQLFLSNAEDLYMKIDSIQAD-ILAANTVNVTKALCL 407
              ++  L    V  C G  L  Q F  + + L  +I SI A+ ++ ++ V + ++  L
Sbjct: 935 VVRRLNELYKASVVSCQGLSLRLQRFFLDKQRLLDRIHSITAERLIFSHAVQMVQSAAL 993


>gi|227430303 CD109 antigen isoform 3 precursor [Homo sapiens]
          Length = 1368

 Score = 30.4 bits (67), Expect = 3.3
 Identities = 17/41 (41%), Positives = 23/41 (56%), Gaps = 1/41 (2%)

Query: 319 ELLYLRVVRGLMAAMGNTDHSNSQRLASLTLECFVQMFPLV 359
           ELLY R   G  +A GN D S S  L++  L CF++  P +
Sbjct: 887 ELLYQRE-DGSFSAFGNYDPSGSTWLSAFVLRCFLEADPYI 926


>gi|227430301 CD109 antigen isoform 2 precursor [Homo sapiens]
          Length = 1428

 Score = 30.4 bits (67), Expect = 3.3
 Identities = 17/41 (41%), Positives = 23/41 (56%), Gaps = 1/41 (2%)

Query: 319  ELLYLRVVRGLMAAMGNTDHSNSQRLASLTLECFVQMFPLV 359
            ELLY R   G  +A GN D S S  L++  L CF++  P +
Sbjct: 964  ELLYQRE-DGSFSAFGNYDPSGSTWLSAFVLRCFLEADPYI 1003


>gi|115529484 CD109 antigen isoform 1 precursor [Homo sapiens]
          Length = 1445

 Score = 30.4 bits (67), Expect = 3.3
 Identities = 17/41 (41%), Positives = 23/41 (56%), Gaps = 1/41 (2%)

Query: 319  ELLYLRVVRGLMAAMGNTDHSNSQRLASLTLECFVQMFPLV 359
            ELLY R   G  +A GN D S S  L++  L CF++  P +
Sbjct: 964  ELLYQRE-DGSFSAFGNYDPSGSTWLSAFVLRCFLEADPYI 1003


>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
           sapiens]
          Length = 830

 Score = 30.4 bits (67), Expect = 3.3
 Identities = 15/40 (37%), Positives = 24/40 (60%)

Query: 272 EISKLQAKILSDPSVLQLTPSLPMFLQQAAAAKAIGVLAR 311
           EI+KL + I+S+  +  +TP +  F  Q AAA+ +  L R
Sbjct: 434 EITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLR 473


>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
           sapiens]
          Length = 824

 Score = 30.4 bits (67), Expect = 3.3
 Identities = 15/40 (37%), Positives = 24/40 (60%)

Query: 272 EISKLQAKILSDPSVLQLTPSLPMFLQQAAAAKAIGVLAR 311
           EI+KL + I+S+  +  +TP +  F  Q AAA+ +  L R
Sbjct: 428 EITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLR 467


>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
            sapiens]
          Length = 5033

 Score = 29.6 bits (65), Expect = 5.7
 Identities = 29/141 (20%), Positives = 62/141 (43%), Gaps = 14/141 (9%)

Query: 115  EKIKEEAKKESVKLLQVIANSGRTYKELICESYGVRSIAEFLAKS-------KSEETQEE 167
            E+++E+      +L+   + +  T K  + E Y   + A+ +AKS       ++ E +EE
Sbjct: 3683 EEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEEGGENGEAEEE 3742

Query: 168  VQVLLDSLVHGNPKYQNQVYKGLIALLPCESPKAQQLSLQTLRTAQPIIGTTHPSIVDCV 227
            V+V  +       + Q +  + L       +  A ++ LQ +   +   G    S +   
Sbjct: 3743 VEVSFE-------EKQMEKQRLLYQQARLHTRGAAEMVLQMISACKGETGAMVSSTLKLG 3795

Query: 228  LKVLGTMHLEVQYEAIELIKD 248
            + +L   + EVQ + ++ +KD
Sbjct: 3796 ISILNGGNAEVQQKMLDYLKD 3816


>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
            sapiens]
          Length = 5038

 Score = 29.6 bits (65), Expect = 5.7
 Identities = 29/141 (20%), Positives = 62/141 (43%), Gaps = 14/141 (9%)

Query: 115  EKIKEEAKKESVKLLQVIANSGRTYKELICESYGVRSIAEFLAKS-------KSEETQEE 167
            E+++E+      +L+   + +  T K  + E Y   + A+ +AKS       ++ E +EE
Sbjct: 3688 EEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEEGGENGEAEEE 3747

Query: 168  VQVLLDSLVHGNPKYQNQVYKGLIALLPCESPKAQQLSLQTLRTAQPIIGTTHPSIVDCV 227
            V+V  +       + Q +  + L       +  A ++ LQ +   +   G    S +   
Sbjct: 3748 VEVSFE-------EKQMEKQRLLYQQARLHTRGAAEMVLQMISACKGETGAMVSSTLKLG 3800

Query: 228  LKVLGTMHLEVQYEAIELIKD 248
            + +L   + EVQ + ++ +KD
Sbjct: 3801 ISILNGGNAEVQQKMLDYLKD 3821


>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
          Length = 822

 Score = 29.6 bits (65), Expect = 5.7
 Identities = 32/119 (26%), Positives = 56/119 (47%), Gaps = 17/119 (14%)

Query: 138 TYKELICESYGVRSIAEFLAKSKSEETQEEVQVLLDSLVHGNPKYQNQVYKGL------I 191
           T K++I +  GV  +   + K K      E  +L + L  GN     +VYKG       +
Sbjct: 533 TTKQVITKKSGV-VLLNPIPKDKKWILSHEDVILGELLGKGN---FGEVYKGTLKDKTSV 588

Query: 192 ALLPCESPKAQQLSLQTLRTAQPIIGTTHPSIVDCVLKVLGTMHLEVQYEAIELIKDLV 250
           A+  C+    Q+L ++ L+ A+ +    HP+IV    K++G      Q + + +I +LV
Sbjct: 589 AVKTCKEDLPQELKIKFLQEAKILKQYDHPNIV----KLIGVC---TQRQPVYIIMELV 640


>gi|227498241 actin-like 8 [Homo sapiens]
          Length = 366

 Score = 29.3 bits (64), Expect = 7.4
 Identities = 23/90 (25%), Positives = 43/90 (47%), Gaps = 14/90 (15%)

Query: 351 CFVQMFPLVAEHVRKCMGEELYQLFLSNAEDLYMKIDSIQADILAANTVNVTKALCLHGS 410
           C + + PL+  HV  C G  LY  F    + L+ +        L  + V+ TKA    GS
Sbjct: 283 CEISLRPLLVSHVMACGGNTLYPGF---TKRLFRE--------LMGDHVSSTKATVWEGS 331

Query: 411 SYSMNTLYGSRDSAQMAYLTHFEEDVESKE 440
           + + +   G   ++ +A+L+ ++ +  S+E
Sbjct: 332 NRNFSVWLG---ASVVAHLSTYQSEWMSRE 358


>gi|224465231 solute carrier family 9, member 11 [Homo sapiens]
          Length = 1124

 Score = 29.3 bits (64), Expect = 7.4
 Identities = 22/74 (29%), Positives = 39/74 (52%), Gaps = 6/74 (8%)

Query: 79  LLRSIGIFLSAVSSNRYLIEFLEVGGVLTLLEI-LGLEKIKEEAKKESV--KLLQVIANS 135
           +L +I +  S V    Y++EFL + G L L  + L L+ +  + K E V  K L++ ++ 
Sbjct: 250 MLTNIILCFSMVYMTFYIVEFLGMSGTLALAAVGLNLDSLTFKPKIELVITKFLRIFSS- 308

Query: 136 GRTYKELICESYGV 149
              Y+ LI   +G+
Sbjct: 309 --VYEHLIYAFFGI 320


>gi|112420977 TBP-interacting protein isoform 2 [Homo sapiens]
          Length = 1119

 Score = 28.9 bits (63), Expect = 9.7
 Identities = 25/91 (27%), Positives = 46/91 (50%), Gaps = 13/91 (14%)

Query: 155 FLAKSK--SEETQEEVQVLLDSLVHGNPKYQNQVYKGLIALLPCESPKAQQLSLQTLRTA 212
           F+A S   SE  ++ +Q+  DS        + +V K L+ LL  ++ + Q L+++ L   
Sbjct: 24  FMATSDLMSELQKDSIQLDEDS--------ERKVVKMLLRLLEDKNGEVQNLAVKWLGVP 75

Query: 213 QPIIGTTHPSIVDCVLKVLGTMHLEVQYEAI 243
              +G  H S++ C+L  L +  L V+  A+
Sbjct: 76  ---LGAFHASLLHCLLPQLSSPRLAVRKRAV 103


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.132    0.358 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,618,323
Number of Sequences: 37866
Number of extensions: 526248
Number of successful extensions: 1600
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 1594
Number of HSP's gapped (non-prelim): 18
length of query: 440
length of database: 18,247,518
effective HSP length: 105
effective length of query: 335
effective length of database: 14,271,588
effective search space: 4780981980
effective search space used: 4780981980
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
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