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Search of human proteins with 222144244
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
(680 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 1388 0.0
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 1327 0.0
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 1318 0.0
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 1316 0.0
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 1258 0.0
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 1257 0.0
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 1250 0.0
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 1016 0.0
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 1015 0.0
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 1003 0.0
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 1002 0.0
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 936 0.0
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 926 0.0
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 903 0.0
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 895 0.0
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 829 0.0
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 829 0.0
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 804 0.0
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 752 0.0
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 598 e-171
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 324 2e-88
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 324 2e-88
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 323 4e-88
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 318 8e-87
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur... 310 2e-84
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur... 310 4e-84
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 289 7e-78
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 287 3e-77
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 244 2e-64
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 244 2e-64
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 1388 bits (3592), Expect = 0.0
Identities = 680/680 (100%), Positives = 680/680 (100%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 120
NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV
Sbjct: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 120
Query: 121 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180
RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV
Sbjct: 121 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180
Query: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFN 240
VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFN
Sbjct: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFN 240
Query: 241 VTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLI 300
VTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLI
Sbjct: 241 VTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLI 300
Query: 301 ACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 360
ACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT
Sbjct: 301 ACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 360
Query: 361 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 420
TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP
Sbjct: 361 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 420
Query: 421 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 480
KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS
Sbjct: 421 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 480
Query: 481 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 540
KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA
Sbjct: 481 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 540
Query: 541 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 600
ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS
Sbjct: 541 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 600
Query: 601 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 660
FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP
Sbjct: 601 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 660
Query: 661 TFKQLVEDLDRILTLTTNEI 680
TFKQLVEDLDRILTLTTNEI
Sbjct: 661 TFKQLVEDLDRILTLTTNEI 680
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 1327 bits (3434), Expect = 0.0
Identities = 654/681 (96%), Positives = 662/681 (97%), Gaps = 5/681 (0%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 120
NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV
Sbjct: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 120
Query: 121 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180
RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV
Sbjct: 121 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180
Query: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALF- 239
VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK +G+N+++ E+ L+
Sbjct: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 240
Query: 240 -NVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVF 298
NVT DAGEY C N IG + SAWLTVLP APGREKEITASPDYLEIAIYCIGVF
Sbjct: 241 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP---APGREKEITASPDYLEIAIYCIGVF 297
Query: 299 LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 358
LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR
Sbjct: 298 LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 357
Query: 359 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 418
ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD
Sbjct: 358 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 417
Query: 419 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 478
KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY
Sbjct: 418 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 477
Query: 479 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 538
ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD
Sbjct: 478 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 537
Query: 539 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 598
LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV
Sbjct: 538 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 597
Query: 599 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 658
WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ
Sbjct: 598 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 657
Query: 659 RPTFKQLVEDLDRILTLTTNE 679
RPTFKQLVEDLDRILTLTTNE
Sbjct: 658 RPTFKQLVEDLDRILTLTTNE 678
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 1318 bits (3411), Expect = 0.0
Identities = 644/644 (100%), Positives = 644/644 (100%)
Query: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP
Sbjct: 126 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 185
Query: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH
Sbjct: 186 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 245
Query: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG
Sbjct: 246 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 305
Query: 217 LPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPG 276
LPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPG
Sbjct: 306 LPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPG 365
Query: 277 REKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPL 336
REKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPL
Sbjct: 366 REKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPL 425
Query: 337 RRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLG 396
RRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLG
Sbjct: 426 RRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLG 485
Query: 397 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 456
KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH
Sbjct: 486 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 545
Query: 457 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 516
KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV
Sbjct: 546 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 605
Query: 517 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 576
SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR
Sbjct: 606 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 665
Query: 577 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 636
LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK
Sbjct: 666 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 725
Query: 637 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI 680
PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI
Sbjct: 726 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI 769
Score = 82.8 bits (203), Expect = 1e-15
Identities = 78/300 (26%), Positives = 114/300 (38%), Gaps = 78/300 (26%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117
T + + ++ +++ RC + W K+G +R IG
Sbjct: 40 -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
Query: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161
Y L ++ P D G Y C S + ++V +
Sbjct: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Query: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212
R+P+ + + V+F C + P ++W+ KNG ++
Sbjct: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWL----KNGKEF 198
Query: 213 GPDGLPYLKVLKHSGINSSNAE-VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK 271
+ + G N L + +V +D G Y C V N G N + L V+ +
Sbjct: 199 KQEH-------RIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVER 251
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 1316 bits (3407), Expect = 0.0
Identities = 643/643 (100%), Positives = 643/643 (100%)
Query: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP
Sbjct: 126 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 185
Query: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH
Sbjct: 186 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 245
Query: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG
Sbjct: 246 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 305
Query: 217 LPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPG 276
LPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPG
Sbjct: 306 LPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPG 365
Query: 277 REKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPL 336
REKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPL
Sbjct: 366 REKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPL 425
Query: 337 RRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLG 396
RRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLG
Sbjct: 426 RRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLG 485
Query: 397 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 456
KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH
Sbjct: 486 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 545
Query: 457 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 516
KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV
Sbjct: 546 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 605
Query: 517 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 576
SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR
Sbjct: 606 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 665
Query: 577 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 636
LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK
Sbjct: 666 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 725
Query: 637 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 679
PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE
Sbjct: 726 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
Score = 82.8 bits (203), Expect = 1e-15
Identities = 78/300 (26%), Positives = 114/300 (38%), Gaps = 78/300 (26%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117
T + + ++ +++ RC + W K+G +R IG
Sbjct: 40 -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
Query: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161
Y L ++ P D G Y C S + ++V +
Sbjct: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Query: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212
R+P+ + + V+F C + P ++W+ KNG ++
Sbjct: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWL----KNGKEF 198
Query: 213 GPDGLPYLKVLKHSGINSSNAE-VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK 271
+ + G N L + +V +D G Y C V N G N + L V+ +
Sbjct: 199 KQEH-------RIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVER 251
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 1258 bits (3256), Expect = 0.0
Identities = 627/681 (92%), Positives = 635/681 (93%), Gaps = 31/681 (4%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE A
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGA---------------------- 38
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 120
PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV
Sbjct: 39 ----PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
Query: 121 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180
RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV
Sbjct: 95 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
Query: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALF- 239
VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK +G+N+++ E+ L+
Sbjct: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
Query: 240 -NVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVF 298
NVT DAGEY C N IG + SAWLTVLP APGREKEITASPDYLEIAIYCIGVF
Sbjct: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP---APGREKEITASPDYLEIAIYCIGVF 271
Query: 299 LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 358
LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR
Sbjct: 272 LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 331
Query: 359 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 418
ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD
Sbjct: 332 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 391
Query: 419 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 478
KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY
Sbjct: 392 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 451
Query: 479 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 538
ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD
Sbjct: 452 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 511
Query: 539 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 598
LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV
Sbjct: 512 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 571
Query: 599 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 658
WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ
Sbjct: 572 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 631
Query: 659 RPTFKQLVEDLDRILTLTTNE 679
RPTFKQLVEDLDRILTLTTNE
Sbjct: 632 RPTFKQLVEDLDRILTLTTNE 652
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 1257 bits (3253), Expect = 0.0
Identities = 618/645 (95%), Positives = 626/645 (97%), Gaps = 5/645 (0%)
Query: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP
Sbjct: 126 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 185
Query: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH
Sbjct: 186 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 245
Query: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG
Sbjct: 246 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 305
Query: 217 LPYLKVLKHSGINSSNAEVLALF--NVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQA 274
LPYLKVLK +G+N+++ E+ L+ NVT DAGEY C N IG + SAWLTVLP A
Sbjct: 306 LPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP---A 362
Query: 275 PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 334
PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI
Sbjct: 363 PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 422
Query: 335 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 394
PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT
Sbjct: 423 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 482
Query: 395 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 454
LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG
Sbjct: 483 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 542
Query: 455 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 514
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD
Sbjct: 543 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 602
Query: 515 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 574
LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN
Sbjct: 603 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 662
Query: 575 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 634
GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM
Sbjct: 663 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 722
Query: 635 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 679
DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE
Sbjct: 723 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 767
Score = 82.8 bits (203), Expect = 1e-15
Identities = 78/300 (26%), Positives = 114/300 (38%), Gaps = 78/300 (26%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117
T + + ++ +++ RC + W K+G +R IG
Sbjct: 40 -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
Query: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161
Y L ++ P D G Y C S + ++V +
Sbjct: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Query: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212
R+P+ + + V+F C + P ++W+ KNG ++
Sbjct: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWL----KNGKEF 198
Query: 213 GPDGLPYLKVLKHSGINSSNAE-VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK 271
+ + G N L + +V +D G Y C V N G N + L V+ +
Sbjct: 199 KQEH-------RIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVER 251
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 1250 bits (3234), Expect = 0.0
Identities = 625/681 (91%), Positives = 633/681 (92%), Gaps = 33/681 (4%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE A
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGA---------------------- 38
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 120
PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV
Sbjct: 39 ----PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
Query: 121 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180
RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV
Sbjct: 95 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
Query: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALF- 239
VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK +G+N+++ E+ L+
Sbjct: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
Query: 240 -NVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVF 298
NVT DAGEY C N IG + SAWLTVLP APGREKEITASPDYLEIAIYCIGVF
Sbjct: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP---APGREKEITASPDYLEIAIYCIGVF 271
Query: 299 LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 358
LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV SAESSSSMNSNTPLVR
Sbjct: 272 LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVR 329
Query: 359 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 418
ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD
Sbjct: 330 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 389
Query: 419 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 478
KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY
Sbjct: 390 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 449
Query: 479 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 538
ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD
Sbjct: 450 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 509
Query: 539 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 598
LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV
Sbjct: 510 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 569
Query: 599 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 658
WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ
Sbjct: 570 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 629
Query: 659 RPTFKQLVEDLDRILTLTTNE 679
RPTFKQLVEDLDRILTLTTNE
Sbjct: 630 RPTFKQLVEDLDRILTLTTNE 650
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 1016 bits (2626), Expect = 0.0
Identities = 502/684 (73%), Positives = 570/684 (83%), Gaps = 16/684 (2%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
M SW + V+ ATL ARPS TL +DA+ S +D+DD D + E N
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPS------PTLPEQDALPSSEDDDDDDDSSSEEKETDN 54
Query: 61 NKR---APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGG 117
K APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGG
Sbjct: 55 TKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGG 114
Query: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANA 177
YKVR WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN
Sbjct: 115 YKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANK 174
Query: 178 STVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE--V 235
+ +G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK +G+N+++ E V
Sbjct: 175 TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEV 234
Query: 236 LALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCI 295
L L NV+ DAGEY C N IG ++ SAWLTVL +A + SP YLEI IYC
Sbjct: 235 LHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL---EALEERPAVMTSPLYLEIIIYCT 291
Query: 296 GVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTP 355
G FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS
Sbjct: 292 GAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 351
Query: 356 LVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGI 415
LVR +RLSS+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+
Sbjct: 352 LVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGL 409
Query: 416 DKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVI 475
DKDKP VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVI
Sbjct: 410 DKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVI 469
Query: 476 VEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCI 535
VEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCI
Sbjct: 470 VEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCI 529
Query: 536 HRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQ 595
HRDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQ
Sbjct: 530 HRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQ 589
Query: 596 SDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAV 655
SDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAV
Sbjct: 590 SDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAV 649
Query: 656 PSQRPTFKQLVEDLDRILTLTTNE 679
PSQRPTFKQLVEDLDRI+ LT+N+
Sbjct: 650 PSQRPTFKQLVEDLDRIVALTSNQ 673
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 1015 bits (2624), Expect = 0.0
Identities = 502/686 (73%), Positives = 570/686 (83%), Gaps = 18/686 (2%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
M SW + V+ ATL ARPS TL +DA+ S +D+DD D + E N
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPS------PTLPEQDALPSSEDDDDDDDSSSEEKETDN 54
Query: 61 NKR-----APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRI 115
K APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRI
Sbjct: 55 TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRI 114
Query: 116 GGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPA 175
GGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPA
Sbjct: 115 GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPA 174
Query: 176 NASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE- 234
N + +G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK +G+N+++ E
Sbjct: 175 NKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM 234
Query: 235 -VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIY 293
VL L NV+ DAGEY C N IG ++ SAWLTVL +A + SP YLEI IY
Sbjct: 235 EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL---EALEERPAVMTSPLYLEIIIY 291
Query: 294 CIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSN 353
C G FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS
Sbjct: 292 CTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSG 351
Query: 354 TPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAV 413
LVR +RLSS+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+
Sbjct: 352 VLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAI 409
Query: 414 GIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLY 473
G+DKDKP VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLY
Sbjct: 410 GLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY 469
Query: 474 VIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQK 533
VIVEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+K
Sbjct: 470 VIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK 529
Query: 534 CIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYT 593
CIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YT
Sbjct: 530 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT 589
Query: 594 HQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWH 653
HQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWH
Sbjct: 590 HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH 649
Query: 654 AVPSQRPTFKQLVEDLDRILTLTTNE 679
AVPSQRPTFKQLVEDLDRI+ LT+N+
Sbjct: 650 AVPSQRPTFKQLVEDLDRIVALTSNQ 675
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 1003 bits (2592), Expect = 0.0
Identities = 492/662 (74%), Positives = 559/662 (84%), Gaps = 10/662 (1%)
Query: 23 PSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHA 79
PS S ++ DA+ S +D+DD D + E N K APYWT+ EKMEK+LHA
Sbjct: 106 PSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHA 165
Query: 80 VPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGN 139
VPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGN
Sbjct: 166 VPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGN 225
Query: 140 YTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHI 199
YTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHI
Sbjct: 226 YTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHI 285
Query: 200 QWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYI 257
QW+KH+E NGSK GPD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N I
Sbjct: 286 QWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSI 345
Query: 258 GQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTK 317
G ++ SAWLTVL +A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TK
Sbjct: 346 GLSHHSAWLTVL---EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTK 402
Query: 318 KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSE 377
K DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSE
Sbjct: 403 KSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSE 460
Query: 378 YELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATE 437
YELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATE
Sbjct: 461 YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATE 520
Query: 438 KDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGME 497
KDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+E
Sbjct: 521 KDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLE 580
Query: 498 YSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADF 557
Y Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADF
Sbjct: 581 YCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF 640
Query: 558 GLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYP 617
GLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYP
Sbjct: 641 GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYP 700
Query: 618 GIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 677
G+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+
Sbjct: 701 GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS 760
Query: 678 NE 679
N+
Sbjct: 761 NQ 762
Score = 38.1 bits (87), Expect = 0.027
Identities = 62/302 (20%), Positives = 105/302 (34%), Gaps = 85/302 (28%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
M SW + V+ ATL ARPS +L E
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPE------------------------------- 29
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGY 118
+A W ++E L V + ++ RC + + ++ WL++G + + +R I G
Sbjct: 30 --QAQPWGAPVEVESFL--VHPGDLLQLRCRLRDD-VQSINWLRDGVQLAESNRTRITGE 84
Query: 119 KVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPH------------- 165
+V ++ VP+D G Y CV + GS + ++V + P
Sbjct: 85 EVE-------VQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSE 137
Query: 166 ---------RPILQAGLPANA------STVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGS 210
P+ + V+F C P ++W+ KNG
Sbjct: 138 EKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWL----KNGK 193
Query: 211 KYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVL 269
++ PD + G A + + +V +D G Y C V N G N + L V+
Sbjct: 194 EFKPDH-------RIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVV 246
Query: 270 PK 271
+
Sbjct: 247 ER 248
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 1002 bits (2590), Expect = 0.0
Identities = 492/664 (74%), Positives = 559/664 (84%), Gaps = 12/664 (1%)
Query: 23 PSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRL 77
PS S ++ DA+ S +D+DD D + E N K APYWT+ EKMEK+L
Sbjct: 106 PSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKL 165
Query: 78 HAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDK 137
HAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDK
Sbjct: 166 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
Query: 138 GNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQP 197
GNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QP
Sbjct: 226 GNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQP 285
Query: 198 HIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSN 255
HIQW+KH+E NGSK GPD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N
Sbjct: 286 HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGN 345
Query: 256 YIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNT 315
IG ++ SAWLTVL +A + SP YLEI IYC G FLI+CMV +VI+ +MK+
Sbjct: 346 SIGLSHHSAWLTVL---EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSG 402
Query: 316 TKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGV 375
TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGV
Sbjct: 403 TKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGV 460
Query: 376 SEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDA 435
SEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DA
Sbjct: 461 SEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA 520
Query: 436 TEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPG 495
TEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG
Sbjct: 521 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPG 580
Query: 496 MEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIA 555
+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIA
Sbjct: 581 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 640
Query: 556 DFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSP 615
DFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSP
Sbjct: 641 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 700
Query: 616 YPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTL 675
YPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ L
Sbjct: 701 YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 760
Query: 676 TTNE 679
T+N+
Sbjct: 761 TSNQ 764
Score = 38.5 bits (88), Expect = 0.021
Identities = 64/304 (21%), Positives = 106/304 (34%), Gaps = 87/304 (28%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
M SW + V+ ATL ARPS +L E
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPE------------------------------- 29
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGY 118
+A W ++E L V + ++ RC + + ++ WL++G + + +R I G
Sbjct: 30 --QAQPWGAPVEVESFL--VHPGDLLQLRCRLRDD-VQSINWLRDGVQLAESNRTRITGE 84
Query: 119 KVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPH------------- 165
+V ++ VP+D G Y CV + GS + ++V + P
Sbjct: 85 EVE-------VQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSE 137
Query: 166 -------RPILQAGLPANAS----------TVVGGDVEFVCKVYSDAQPHIQWIKHVEKN 208
+P P S V+F C P ++W+ KN
Sbjct: 138 EKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWL----KN 193
Query: 209 GSKYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTEADAGEYICKVSNYIGQANQSAWLT 267
G ++ PD + G A + + +V +D G Y C V N G N + L
Sbjct: 194 GKEFKPDH-------RIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLD 246
Query: 268 VLPK 271
V+ +
Sbjct: 247 VVER 250
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 936 bits (2420), Expect = 0.0
Identities = 468/645 (72%), Positives = 536/645 (83%), Gaps = 15/645 (2%)
Query: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
DA SSGDDED D AED + APYWT E+M+K+L AVPAANTV+FRCPA GNP
Sbjct: 127 DAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
Query: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY
Sbjct: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
Query: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG
Sbjct: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
Query: 217 LPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQA 274
PY+ VLK +G N+++ E VL+L NVT DAGEY C N IG ++ SAWL VLP ++
Sbjct: 303 TPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEE 362
Query: 275 PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 334
E A Y I Y +G FL +V V LCR+++ KK P VHK++ R
Sbjct: 363 LVEADE--AGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-RF 417
Query: 335 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 394
PL+RQV S ES++SM+SNTPLVRI RLSS + P LA VSE ELP DPKWE R +LT
Sbjct: 418 PLKRQV--SLESNASMSSNTPLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLT 473
Query: 395 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 454
LGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIG
Sbjct: 474 LGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIG 533
Query: 455 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 514
KHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFKD
Sbjct: 534 KHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKD 593
Query: 515 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 574
LVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTN
Sbjct: 594 LVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTN 653
Query: 575 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 634
GRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRM
Sbjct: 654 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRM 713
Query: 635 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 679
DKPANCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR+LT+T+ +
Sbjct: 714 DKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTD 758
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 926 bits (2394), Expect = 0.0
Identities = 464/648 (71%), Positives = 537/648 (82%), Gaps = 19/648 (2%)
Query: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
DA SSGDDED D AED + APYWT E+M+K+L AVPAANTV+FRCPA GNP
Sbjct: 127 DAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
Query: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY
Sbjct: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
Query: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG
Sbjct: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
Query: 217 LPYLKVLKHSGINSSNAEV-LALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAP 275
PY+ VLK S A+V L L NV+E D GEY+C+ +N+IG A ++ WL+V + A
Sbjct: 303 TPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAA- 361
Query: 276 GREKEITASPD----YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT 331
E+E+ + + Y I Y +G FL +V V LCR+++ KK P VHK++
Sbjct: 362 --EEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS 417
Query: 332 KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 391
R PL+RQV S ES++SM+SNTPLVRI RLSS + P LA VSE ELP DPKWE R
Sbjct: 418 -RFPLKRQV--SLESNASMSSNTPLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRA 472
Query: 392 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 451
+LTLGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMK
Sbjct: 473 RLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMK 532
Query: 452 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 511
MIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+LRARRPPG++YS+D + PEEQ+T
Sbjct: 533 MIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLT 592
Query: 512 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 571
FKDLVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKK
Sbjct: 593 FKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK 652
Query: 572 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 631
TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEG
Sbjct: 653 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEG 712
Query: 632 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 679
HRMDKPANCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR+LT+T+ +
Sbjct: 713 HRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTD 760
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 903 bits (2333), Expect = 0.0
Identities = 456/664 (68%), Positives = 522/664 (78%), Gaps = 49/664 (7%)
Query: 23 PSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRL 77
PS S ++ DA+ S +D+DD D + E N K APYWT+ EKMEK+L
Sbjct: 106 PSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKL 165
Query: 78 HAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDK 137
HAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDK
Sbjct: 166 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
Query: 138 GNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQP 197
GNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QP
Sbjct: 226 GNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQP 285
Query: 198 HIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSN 255
HIQW+KH+E NGSK GPD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N
Sbjct: 286 HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGN 345
Query: 256 YIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNT 315
IG ++ SAWLTVL +A + SP YLEI IYC G FLI+CMV +VI+ +MK+
Sbjct: 346 SIGLSHHSAWLTVL---EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSG 402
Query: 316 TKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGV 375
TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGV
Sbjct: 403 TKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGV 460
Query: 376 SEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDA 435
SEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DA
Sbjct: 461 SEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA 520
Query: 436 TEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPG 495
TEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG
Sbjct: 521 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPG 580
Query: 496 MEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIA 555
+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIA
Sbjct: 581 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 640
Query: 556 DFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSP 615
DFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSP
Sbjct: 641 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 700
Query: 616 YPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTL 675
YPG+PVEEL FKQLVEDLDRI+ L
Sbjct: 701 YPGVPVEEL-------------------------------------FKQLVEDLDRIVAL 723
Query: 676 TTNE 679
T+N+
Sbjct: 724 TSNQ 727
Score = 38.5 bits (88), Expect = 0.021
Identities = 64/304 (21%), Positives = 106/304 (34%), Gaps = 87/304 (28%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
M SW + V+ ATL ARPS +L E
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPE------------------------------- 29
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGY 118
+A W ++E L V + ++ RC + + ++ WL++G + + +R I G
Sbjct: 30 --QAQPWGAPVEVESFL--VHPGDLLQLRCRLRDD-VQSINWLRDGVQLAESNRTRITGE 84
Query: 119 KVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPH------------- 165
+V ++ VP+D G Y CV + GS + ++V + P
Sbjct: 85 EVE-------VQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSE 137
Query: 166 -------RPILQAGLPANAS----------TVVGGDVEFVCKVYSDAQPHIQWIKHVEKN 208
+P P S V+F C P ++W+ KN
Sbjct: 138 EKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWL----KN 193
Query: 209 GSKYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTEADAGEYICKVSNYIGQANQSAWLT 267
G ++ PD + G A + + +V +D G Y C V N G N + L
Sbjct: 194 GKEFKPDH-------RIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLD 246
Query: 268 VLPK 271
V+ +
Sbjct: 247 VVER 250
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 895 bits (2314), Expect = 0.0
Identities = 484/708 (68%), Positives = 519/708 (73%), Gaps = 82/708 (11%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117
T + + ++ +++ RC + W K+G +R IG
Sbjct: 40 -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
Query: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161
Y L ++ P D G Y C S + ++V +
Sbjct: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Query: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212
R+P+ + + V+F C + P ++W+K NG ++
Sbjct: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
Query: 213 GPDGLPYLKVLKHSGINSSNAE-VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK 271
+ + G N L + +V +D G Y C V N G N + L V+
Sbjct: 199 KQEH-------RIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV-- 249
Query: 272 QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT 331
APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT
Sbjct: 250 --APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT 307
Query: 332 KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 391
KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD
Sbjct: 308 KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 367
Query: 392 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 451
KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK
Sbjct: 368 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 427
Query: 452 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 511
MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT
Sbjct: 428 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 487
Query: 512 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 571
FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK
Sbjct: 488 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 547
Query: 572 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 631
TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG
Sbjct: 548 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 607
Query: 632 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 679
HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE
Sbjct: 608 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 655
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 829 bits (2141), Expect = 0.0
Identities = 419/677 (61%), Positives = 515/677 (76%), Gaps = 22/677 (3%)
Query: 5 GRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRA 64
GR++CL AR S ++++ TL D+++S +D++D D + +S ++A
Sbjct: 97 GRYLCL----------ARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQA 146
Query: 65 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 124
PYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++R+QH
Sbjct: 147 PYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQH 206
Query: 125 WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 184
WSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + VVG D
Sbjct: 207 WSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSD 266
Query: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEA 244
VE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK + INSS EVL L NV+
Sbjct: 267 VELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAE 326
Query: 245 DAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPD--YLEIAIYCIGVFLIAC 302
DAGEY C N IG + QSAWLTVLP++ A+P+ Y +I +Y G +A
Sbjct: 327 DAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWT----AAAPEARYTDIILYASGSLALAV 382
Query: 303 MVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTR 362
+++ L R + + PA + R PL RQ S ES SS S++ LVR R
Sbjct: 383 LLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQF--SLESGSSGKSSSSLVR-GVR 437
Query: 363 LSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKE 422
LSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D +P +
Sbjct: 438 LSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQ 496
Query: 423 AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 482
A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KG
Sbjct: 497 ASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKG 556
Query: 483 NLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAAR 542
NLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIHRDLAAR
Sbjct: 557 NLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAAR 616
Query: 543 NVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 602
NVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDVWSFG
Sbjct: 617 NVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFG 676
Query: 603 VLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF 662
+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTF
Sbjct: 677 ILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTF 736
Query: 663 KQLVEDLDRILTLTTNE 679
KQLVE LD++L + E
Sbjct: 737 KQLVEALDKVLLAVSEE 753
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 829 bits (2141), Expect = 0.0
Identities = 419/677 (61%), Positives = 515/677 (76%), Gaps = 22/677 (3%)
Query: 5 GRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRA 64
GR++CL AR S ++++ TL D+++S +D++D D + +S ++A
Sbjct: 97 GRYLCL----------ARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQA 146
Query: 65 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 124
PYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++R+QH
Sbjct: 147 PYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQH 206
Query: 125 WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 184
WSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + VVG D
Sbjct: 207 WSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSD 266
Query: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEA 244
VE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK + INSS EVL L NV+
Sbjct: 267 VELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAE 326
Query: 245 DAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPD--YLEIAIYCIGVFLIAC 302
DAGEY C N IG + QSAWLTVLP++ A+P+ Y +I +Y G +A
Sbjct: 327 DAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWT----AAAPEARYTDIILYASGSLALAV 382
Query: 303 MVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTR 362
+++ L R + + PA + R PL RQ S ES SS S++ LVR R
Sbjct: 383 LLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQF--SLESGSSGKSSSSLVR-GVR 437
Query: 363 LSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKE 422
LSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D +P +
Sbjct: 438 LSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQ 496
Query: 423 AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 482
A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KG
Sbjct: 497 ASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKG 556
Query: 483 NLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAAR 542
NLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIHRDLAAR
Sbjct: 557 NLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAAR 616
Query: 543 NVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 602
NVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDVWSFG
Sbjct: 617 NVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFG 676
Query: 603 VLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF 662
+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTF
Sbjct: 677 ILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTF 736
Query: 663 KQLVEDLDRILTLTTNE 679
KQLVE LD++L + E
Sbjct: 737 KQLVEALDKVLLAVSEE 753
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 804 bits (2077), Expect = 0.0
Identities = 412/675 (61%), Positives = 496/675 (73%), Gaps = 58/675 (8%)
Query: 5 GRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRA 64
GR++CL AR S ++++ TL D+++S +D++D D + +S ++A
Sbjct: 97 GRYLCL----------ARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQA 146
Query: 65 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 124
PYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++R+QH
Sbjct: 147 PYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQH 206
Query: 125 WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 184
WSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + VVG D
Sbjct: 207 WSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSD 266
Query: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEA 244
VE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK + INSS EVL L NV+
Sbjct: 267 VELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAE 326
Query: 245 DAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMV 304
DAGEY C N IG + QSAWLTVLP GR +T D L A
Sbjct: 327 DAGEYTCLAGNSIGLSYQSAWLTVLP---GTGRIPHLTC--DSLTPA------------- 368
Query: 305 VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLS 364
TK P S ES SS S++ LVR RLS
Sbjct: 369 ---------GRTKSPTLQ-------------------FSLESGSSGKSSSSLVR-GVRLS 399
Query: 365 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 424
S+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D +P +A
Sbjct: 400 SSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQAS 458
Query: 425 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 484
TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNL
Sbjct: 459 TVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNL 518
Query: 485 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 544
RE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIHRDLAARNV
Sbjct: 519 REFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNV 578
Query: 545 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 604
LVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDVWSFG+L
Sbjct: 579 LVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGIL 638
Query: 605 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 664
+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTFKQ
Sbjct: 639 LWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQ 698
Query: 665 LVEDLDRILTLTTNE 679
LVE LD++L + E
Sbjct: 699 LVEALDKVLLAVSEE 713
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 752 bits (1941), Expect = 0.0
Identities = 428/713 (60%), Positives = 476/713 (66%), Gaps = 96/713 (13%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117
T + + ++ +++ RC + W K+G +R IG
Sbjct: 40 -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
Query: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161
Y L ++ P D G Y C S + ++V +
Sbjct: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Query: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212
R+P+ + + V+F C + P ++W+K NG ++
Sbjct: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
Query: 213 GPDGLPYLKVLKHSGINSSNAE-VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK 271
+ + G N L + +V +D G Y C V N G N + L V+ +
Sbjct: 199 KQEH-------RIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVER 251
Query: 272 Q-QAPGREKEITASPDYL---EIAIYCIGVFLIACMVVTVILCRMKNTTKK-PDFSSQPA 326
P + + A+ + ++ C V+ A + I KN +K PD
Sbjct: 252 SPHRPILQAGLPANASTVVGGDVEFVC-KVYSDAQPHIQWIKHVEKNGSKYGPD------ 304
Query: 327 VHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKW 386
+P + + VSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKW
Sbjct: 305 ------GLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKW 358
Query: 387 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 446
EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE
Sbjct: 359 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 418
Query: 447 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVP 506
MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVP
Sbjct: 419 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVP 478
Query: 507 EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI 566
EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI
Sbjct: 479 EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI 538
Query: 567 DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK 626
DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK
Sbjct: 539 DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK 598
Query: 627 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 679
LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE
Sbjct: 599 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 651
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 598 bits (1541), Expect = e-171
Identities = 317/503 (63%), Positives = 371/503 (73%), Gaps = 36/503 (7%)
Query: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEA 244
V F C + P I W+K+ + ++ G+ L+H + L + +V +
Sbjct: 172 VRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIK----LRHQQWS------LVMESVVPS 221
Query: 245 DAGEYICKVSNYIGQANQSAWLTVL------PKQQA--PGREKEITASPDYLEIAIYCIG 296
D G Y C V N G Q+ L VL P QA P + + S ++ +C
Sbjct: 222 DRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGS----DVEFHCKV 277
Query: 297 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPL 356
+ + + + PD + V K VS ES++SM+SNTPL
Sbjct: 278 YSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLK------------VSLESNASMSSNTPL 325
Query: 357 VRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 416
VRI RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GID
Sbjct: 326 VRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGID 383
Query: 417 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 476
KD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+V
Sbjct: 384 KDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLV 443
Query: 477 EYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIH 536
EYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIH
Sbjct: 444 EYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIH 503
Query: 537 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 596
RDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQS
Sbjct: 504 RDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 563
Query: 597 DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVP 656
DVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA P
Sbjct: 564 DVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAP 623
Query: 657 SQRPTFKQLVEDLDRILTLTTNE 679
SQRPTFKQLVEDLDR+LT+T+ +
Sbjct: 624 SQRPTFKQLVEDLDRVLTVTSTD 646
Score = 289 bits (739), Expect = 7e-78
Identities = 141/213 (66%), Positives = 165/213 (77%), Gaps = 5/213 (2%)
Query: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
DA SSGDDED D AED + APYWT E+M+K+L AVPAANTV+FRCPA GNP
Sbjct: 127 DAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
Query: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY
Sbjct: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
Query: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG
Sbjct: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
Query: 217 LPYLKVLKHS-GINSSNAEVLALFNVTEADAGE 248
PY+ VLK S N+S + L + +GE
Sbjct: 303 TPYVTVLKVSLESNASMSSNTPLVRIARLSSGE 335
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 324 bits (830), Expect = 2e-88
Identities = 170/344 (49%), Positives = 224/344 (65%), Gaps = 20/344 (5%)
Query: 346 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 398
SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK
Sbjct: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
Query: 399 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 457
LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H
Sbjct: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
Query: 458 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 509
++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E
Sbjct: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
Query: 510 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 569
+T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y
Sbjct: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
Query: 570 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 629
K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
Query: 630 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 673
GHRM++P NC+ E+Y +M CW P +RP F + +DL++++
Sbjct: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 324 bits (830), Expect = 2e-88
Identities = 170/344 (49%), Positives = 224/344 (65%), Gaps = 20/344 (5%)
Query: 346 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 398
SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK
Sbjct: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
Query: 399 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 457
LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H
Sbjct: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
Query: 458 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 509
++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E
Sbjct: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
Query: 510 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 569
+T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y
Sbjct: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
Query: 570 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 629
K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
Query: 630 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 673
GHRM++P NC+ E+Y +M CW P +RP F + +DL++++
Sbjct: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 323 bits (827), Expect = 4e-88
Identities = 230/607 (37%), Positives = 303/607 (49%), Gaps = 127/607 (20%)
Query: 127 LIMESVVPS--DKGNYTCVVENEYGSINHTY--HLDVVERSPHRPILQAGLPANASTVVG 182
LIME S D+G+Y C+ ++ H L V+ER P + L N +T +G
Sbjct: 625 LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIG 681
Query: 183 GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVT 242
+E C + P I W K N + G+ VLK N L + V
Sbjct: 682 ESIEVSCTASGNPPPQIMWFKD---NETLVEDSGI----VLKDGNRN------LTIRRVR 728
Query: 243 EADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIAC 302
+ D G Y C+ + +G A A+ + Q+ E I +G +IA
Sbjct: 729 KEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLE------------IIILVGTAVIAM 776
Query: 303 M--VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 360
++ VI+ R TV + + T
Sbjct: 777 FFWLLLVIILR-----------------------------TVKRANGGELK--------T 799
Query: 361 TRLSSTADTPMLAGVSEYE-LPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 418
LS D L E LP D KWEFPRD+L LGKPLG G FGQV+ A+A GIDK
Sbjct: 800 GYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKT 859
Query: 419 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVE 477
TVAVKMLK+ AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE
Sbjct: 860 ATCR--TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVE 917
Query: 478 YASKGNLREYLRARRPPGMEYS-----------------YDINR---------------- 504
+ GNL YLR++R + Y D+ R
Sbjct: 918 FCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGF 977
Query: 505 --------VPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT 547
V EE+ +T + L+ ++Q+A+GME+LAS+KCIHRDLAARN+L++
Sbjct: 978 VEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLS 1037
Query: 548 ENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWE 607
E NV+KI DFGLARDI Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVL+WE
Sbjct: 1038 EKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWE 1097
Query: 608 IFTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLV 666
IF+LG SPYPG+ ++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LV
Sbjct: 1098 IFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELV 1157
Query: 667 EDLDRIL 673
E L +L
Sbjct: 1158 EHLGNLL 1164
Score = 41.6 bits (96), Expect = 0.002
Identities = 35/124 (28%), Positives = 53/124 (42%), Gaps = 9/124 (7%)
Query: 87 KFRCPAG--GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 144
+ R PA G P P ++W KNG + H I + H IME V D GNYT ++
Sbjct: 347 RVRIPAKYLGYPPPEIKWYKNGIPLESNHTI-----KAGHVLTIME-VSERDTGNYTVIL 400
Query: 145 ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQP-HIQWIK 203
N ++ + +V P + ++ + S G C VY+ P HI W
Sbjct: 401 TNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYW 460
Query: 204 HVEK 207
+E+
Sbjct: 461 QLEE 464
Score = 37.7 bits (86), Expect = 0.035
Identities = 34/140 (24%), Positives = 56/140 (40%), Gaps = 22/140 (15%)
Query: 126 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ--AGLPANASTVVGG 183
+L ++ V SD+G YTC + + ++ + V E +P + +G+ + VG
Sbjct: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHE----KPFVAFGSGMESLVEATVGE 346
Query: 184 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTE 243
V K P I+W K +G+P S VL + V+E
Sbjct: 347 RVRIPAKYLGYPPPEIKWYK-----------NGIPL-----ESNHTIKAGHVLTIMEVSE 390
Query: 244 ADAGEYICKVSNYIGQANQS 263
D G Y ++N I + QS
Sbjct: 391 RDTGNYTVILTNPISKEKQS 410
Score = 36.2 bits (82), Expect = 0.10
Identities = 19/75 (25%), Positives = 38/75 (50%), Gaps = 5/75 (6%)
Query: 68 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 127
T T +E + ++ +++ C A GNP P + W K+ + ++ G +++ + +L
Sbjct: 668 TITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNL 722
Query: 128 IMESVVPSDKGNYTC 142
+ V D+G YTC
Sbjct: 723 TIRRVRKEDEGLYTC 737
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 318 bits (816), Expect = 8e-87
Identities = 215/605 (35%), Positives = 298/605 (49%), Gaps = 123/605 (20%)
Query: 126 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 185
+L + +V D G Y C N Y ++ R P L L ++ + +
Sbjct: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISSST 678
Query: 186 EFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEAD 245
C +P I W K+ K + G I + L + VTE D
Sbjct: 679 TLDCHANGVPEPQITWFKNNHKIQQEPGI-------------ILGPGSSTLFIERVTEED 725
Query: 246 AGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVV 305
G Y CK +N G SA+LTV E + + C+ L +++
Sbjct: 726 EGVYHCKATNQKGSVESSAYLTVQGTSDKSNLE--------LITLTCTCVAATLF-WLLL 776
Query: 306 TVILCRMKNTTK--KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 363
T+ + +MK ++ K D+ S + +PL Q
Sbjct: 777 TLFIRKMKRSSSEIKTDYLS---IIMDPDEVPLDEQCE---------------------- 811
Query: 364 SSTADTPMLAGVSEYELPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKE 422
LP D KWEF R++L LGK LG G FG+VV A A GI K
Sbjct: 812 ---------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR 856
Query: 423 AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASK 481
TVAVKMLK+ AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY
Sbjct: 857 --TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKY 914
Query: 482 GNLREYLRARRP--------------------PGMEYSY--------------------- 500
GNL YL+++R PG+E
Sbjct: 915 GNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQED 974
Query: 501 -DINRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN 550
++ V EE+ +T +DL+S ++Q+ARGME+L+S+KCIHRDLAARN+L++ENN
Sbjct: 975 KSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENN 1034
Query: 551 VMKIADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIF 609
V+KI DFGLARDI N DY +K RLP+KWMAPE++FD++Y+ +SDVWS+GVL+WEIF
Sbjct: 1035 VVKICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIF 1093
Query: 610 TLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 668
+LGGSPYPG+ ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE
Sbjct: 1094 SLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEK 1153
Query: 669 LDRIL 673
L +L
Sbjct: 1154 LGDLL 1158
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 3/82 (3%)
Query: 78 HAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDK 137
H V +++ C A G P P + W KN + +QE G + +L +E V D+
Sbjct: 670 HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGPGSSTLFIERVTEEDE 726
Query: 138 GNYTCVVENEYGSINHTYHLDV 159
G Y C N+ GS+ + +L V
Sbjct: 727 GVYHCKATNQKGSVESSAYLTV 748
Score = 42.0 bits (97), Expect = 0.002
Identities = 64/300 (21%), Positives = 111/300 (37%), Gaps = 36/300 (12%)
Query: 68 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 127
T + ++ L V + + P P + WLK+G + Y R +SL
Sbjct: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRG--YSL 390
Query: 128 IMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 183
I++ V D GNYT ++ N + ++ T ++V + + + + P A +G
Sbjct: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
Query: 184 DVEFVCKVYSDAQPHIQWIKH-VEKNGSKYGPD-----------------GLPYLKVLKH 225
C Y QP I+W H N S+ D G + +
Sbjct: 449 RQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQR 508
Query: 226 SGINSSNAEVLALFNVTEAD-AGEYICKVSNYIGQA--NQSAWLTVLPKQQAPGREKEIT 282
I ++ + V ++ +G YIC SN +G N S ++T +P EK T
Sbjct: 509 MAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT 568
Query: 283 ASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTV 342
D + + C + V ++L + N T S Q +TK + +T+
Sbjct: 569 EGED---LKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMA--ITKEHSITLNLTI 623
>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
[Homo sapiens]
Length = 300
Score = 310 bits (795), Expect = 2e-84
Identities = 148/227 (65%), Positives = 173/227 (76%), Gaps = 9/227 (3%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
M SW + V+ ATL ARPS TL +DA+ S +D+DD D + E N
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPS------PTLPEQDALPSSEDDDDDDDSSSEEKETDN 54
Query: 61 NKR---APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGG 117
K APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGG
Sbjct: 55 TKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGG 114
Query: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANA 177
YKVR WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN
Sbjct: 115 YKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANK 174
Query: 178 STVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK 224
+ +G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK
Sbjct: 175 TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 221
Score = 31.2 bits (69), Expect = 3.3
Identities = 23/88 (26%), Positives = 37/88 (42%), Gaps = 12/88 (13%)
Query: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTE 243
V+F C P ++W+K NG ++ PD + G A + + +V
Sbjct: 83 VKFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRYATWSIIMDSVVP 131
Query: 244 ADAGEYICKVSNYIGQANQSAWLTVLPK 271
+D G Y C V N G N + L V+ +
Sbjct: 132 SDKGNYTCIVENEYGSINHTYQLDVVER 159
>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
[Homo sapiens]
Length = 302
Score = 310 bits (793), Expect = 4e-84
Identities = 148/229 (64%), Positives = 173/229 (75%), Gaps = 11/229 (4%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
M SW + V+ ATL ARPS TL +DA+ S +D+DD D + E N
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPS------PTLPEQDALPSSEDDDDDDDSSSEEKETDN 54
Query: 61 NKR-----APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRI 115
K APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRI
Sbjct: 55 TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRI 114
Query: 116 GGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPA 175
GGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPA
Sbjct: 115 GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPA 174
Query: 176 NASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK 224
N + +G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK
Sbjct: 175 NKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 223
Score = 31.2 bits (69), Expect = 3.3
Identities = 23/88 (26%), Positives = 37/88 (42%), Gaps = 12/88 (13%)
Query: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTE 243
V+F C P ++W+K NG ++ PD + G A + + +V
Sbjct: 85 VKFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRYATWSIIMDSVVP 133
Query: 244 ADAGEYICKVSNYIGQANQSAWLTVLPK 271
+D G Y C V N G N + L V+ +
Sbjct: 134 SDKGNYTCIVENEYGSINHTYQLDVVER 161
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 289 bits (739), Expect = 7e-78
Identities = 209/669 (31%), Positives = 322/669 (48%), Gaps = 125/669 (18%)
Query: 126 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHR--PILQAGLPANASTVVGG 183
+L + S +D G + C N +GS N T L+VV++ P++ + N G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVND----GE 329
Query: 184 DVEFVCKVYSDAQP-HIQWI--------------KHVEKNGSKY----------GPDGLP 218
+V+ + + + +P H QWI K ++ +Y G +G
Sbjct: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGT 389
Query: 219 YLKVLKHSGINSSNAEVLALFNV---TEADAGEYICKVSNYIGQANQSAWLTVLPKQQAP 275
Y ++ +S +N++ A FNV T+ + Y V+ + + P
Sbjct: 390 YTFLVSNSDVNAAIA-----FNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCP 444
Query: 276 GREKEITASPDYLEIAIYC-----IGVFLIACMVVT-------VILCRMKNTTKKP---- 319
G E+ +AS +++ G ++ + + + C+ N K
Sbjct: 445 GTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYF 504
Query: 320 DFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNS-------NTPLVRITTRLSSTADTPML 372
+F+ + +H T PL + A + P+ + ++ +
Sbjct: 505 NFAFKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNY 564
Query: 373 AGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK 432
+ +LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK
Sbjct: 565 VYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLK 622
Query: 433 DDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR 492
A + L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 623 PSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKR 682
Query: 493 P--------------------------------------PGMEY----------SYDINR 504
PG+ Y S I
Sbjct: 683 DSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGS 742
Query: 505 VPEEQMT------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM 552
E +T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T +
Sbjct: 743 YIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT 802
Query: 553 KIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLG 612
KI DFGLARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG
Sbjct: 803 KICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLG 862
Query: 613 GSPYPGIPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 671
SPYPG+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++
Sbjct: 863 SSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK 922
Query: 672 ILTLTTNEI 680
++ +TN I
Sbjct: 923 QISESTNHI 931
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 287 bits (734), Expect = 3e-77
Identities = 157/363 (43%), Positives = 215/363 (59%), Gaps = 63/363 (17%)
Query: 379 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 438
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632
Query: 439 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 493
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
Query: 494 ---------------------------------PGMEY----------SYDINRVPEEQM 510
PG+ Y S I E +
Sbjct: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752
Query: 511 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 558
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812
Query: 559 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 618
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872
Query: 619 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 677
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932
Query: 678 NEI 680
N I
Sbjct: 933 NHI 935
Score = 30.0 bits (66), Expect = 7.3
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 7/80 (8%)
Query: 126 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHR--PILQAGLPANASTVVGG 183
+L + S +D G + C N +GS N T L+VV++ P++ + N G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVND----GE 329
Query: 184 DVEFVCKVYSDAQP-HIQWI 202
+V+ + + + +P H QWI
Sbjct: 330 NVDLIVEYEAFPKPEHQQWI 349
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 244 bits (623), Expect = 2e-64
Identities = 128/275 (46%), Positives = 182/275 (66%), Gaps = 8/275 (2%)
Query: 399 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 458
+GEG FGQV+ A I KD + + A+K +K+ A++ D D E+E++ +G H N
Sbjct: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
Query: 459 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 518
IINLLGAC G LY+ +EYA GNL ++LR R + ++ I ++ + L+
Sbjct: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
Query: 519 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 578
+ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R + Y K T GRLP
Sbjct: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
Query: 579 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 638
V+WMA E+L VYT SDVWS+GVL+WEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
Query: 639 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 673
NC +E+Y +MR CW P +RP+F Q++ L+R+L
Sbjct: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 244 bits (623), Expect = 2e-64
Identities = 132/283 (46%), Positives = 180/283 (63%), Gaps = 8/283 (2%)
Query: 391 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 450
+ +T +GEG FGQV+ A I KD K + A+KMLK+ A+E D D E+E++
Sbjct: 837 EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891
Query: 451 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 510
+G H NIINLLGAC G LY+ +EYA GNL ++LR R + ++ +
Sbjct: 892 CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951
Query: 511 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 570
+ + L+ A GM+YL+ ++ IHRDLAARNVLV EN KIADFGL+R + Y
Sbjct: 952 SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008
Query: 571 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 630
K T GRLPV+WMA E+L VYT +SDVWSFGVL+WEI +LGG+PY G+ EL++ L +
Sbjct: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068
Query: 631 GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 673
G+RM++P NC +E+Y +MR CW P +RP F Q+ L R+L
Sbjct: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRML 1111
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,932,315
Number of Sequences: 37866
Number of extensions: 1232720
Number of successful extensions: 8980
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 715
Number of HSP's successfully gapped in prelim test: 364
Number of HSP's that attempted gapping in prelim test: 3741
Number of HSP's gapped (non-prelim): 2783
length of query: 680
length of database: 18,247,518
effective HSP length: 109
effective length of query: 571
effective length of database: 14,120,124
effective search space: 8062590804
effective search space used: 8062590804
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.