Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 222144241
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
(704 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 1446 0.0
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 1441 0.0
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 1369 0.0
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 1313 0.0
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 1311 0.0
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 1250 0.0
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 1195 0.0
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 1109 0.0
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 1107 0.0
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 1103 0.0
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 1102 0.0
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 1018 0.0
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 1016 0.0
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 1003 0.0
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 962 0.0
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 876 0.0
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 867 0.0
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 867 0.0
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 847 0.0
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 642 0.0
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 330 3e-90
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 330 3e-90
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 329 6e-90
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 321 1e-87
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur... 289 7e-78
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 289 7e-78
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 289 7e-78
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur... 287 3e-77
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 244 2e-64
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 244 2e-64
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 1446 bits (3744), Expect = 0.0
Identities = 704/704 (100%), Positives = 704/704 (100%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
Query: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN 120
KFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN
Sbjct: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN 120
Query: 121 EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVE 180
EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVE
Sbjct: 121 EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVE 180
Query: 181 KNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSA 240
KNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSA
Sbjct: 181 KNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSA 240
Query: 241 WLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAV 300
WLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAV
Sbjct: 241 WLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAV 300
Query: 301 HKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP 360
HKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP
Sbjct: 301 HKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP 360
Query: 361 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 420
RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM
Sbjct: 361 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 420
Query: 421 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 480
MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ
Sbjct: 421 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 480
Query: 481 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 540
MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY
Sbjct: 481 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 540
Query: 541 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 600
KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK
Sbjct: 541 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 600
Query: 601 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 660
EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE
Sbjct: 601 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 660
Query: 661 QYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 704
QYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
Sbjct: 661 QYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 704
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 1441 bits (3731), Expect = 0.0
Identities = 704/706 (99%), Positives = 704/706 (99%), Gaps = 2/706 (0%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
Query: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN 120
KFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN
Sbjct: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN 120
Query: 121 EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVE 180
EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVE
Sbjct: 121 EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVE 180
Query: 181 KNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSA 240
KNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSA
Sbjct: 181 KNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSA 240
Query: 241 WLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAV 300
WLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAV
Sbjct: 241 WLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAV 300
Query: 301 HKLTKRIPLRRQV--SAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE 358
HKLTKRIPLRRQV SAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE
Sbjct: 301 HKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE 360
Query: 359 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 418
FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM
Sbjct: 361 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 420
Query: 419 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 478
EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE
Sbjct: 421 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 480
Query: 479 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 538
EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID
Sbjct: 481 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 540
Query: 539 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKL 598
YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKL
Sbjct: 541 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKL 600
Query: 599 LKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQP 658
LKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQP
Sbjct: 601 LKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQP 660
Query: 659 LEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 704
LEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
Sbjct: 661 LEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 706
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 1369 bits (3544), Expect = 0.0
Identities = 667/669 (99%), Positives = 667/669 (99%), Gaps = 2/669 (0%)
Query: 38 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ
Sbjct: 153 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 212
Query: 98 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG
Sbjct: 213 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 272
Query: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV
Sbjct: 273 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 332
Query: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV 277
TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV
Sbjct: 333 TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV 392
Query: 278 VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVRITTRLS 335
VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV SAESSSSMNSNTPLVRITTRLS
Sbjct: 393 VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLS 452
Query: 336 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 395
STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV
Sbjct: 453 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 512
Query: 396 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 455
TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 513 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 572
Query: 456 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 515
REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV
Sbjct: 573 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 632
Query: 516 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 575
LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL
Sbjct: 633 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 692
Query: 576 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 635
MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ
Sbjct: 693 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 752
Query: 636 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQY 695
LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQY
Sbjct: 753 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQY 812
Query: 696 PHINGSVKT 704
PHINGSVKT
Sbjct: 813 PHINGSVKT 821
Score = 94.4 bits (233), Expect = 3e-19
Identities = 78/273 (28%), Positives = 114/273 (41%), Gaps = 52/273 (19%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE P T + + ++ ++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58
Query: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117
+ RC + W K+G +R IG Y L ++ P D G Y C
Sbjct: 59 EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108
Query: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152
S + ++V + R+P+ + +
Sbjct: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168
Query: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
V+F C + P ++W+ KNG ++ + + G ++ L
Sbjct: 169 VPAANTVKFRCPAGGNPMPTMRWL----KNGKEFKQEH-------RIGGYKVRNQHWS-L 216
Query: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
+ +V D G YTC+ N G H+ L V+
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 1313 bits (3398), Expect = 0.0
Identities = 653/701 (93%), Positives = 658/701 (93%), Gaps = 28/701 (3%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGA---------------------- 38
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE A
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 39 ----PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV
Sbjct: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 120
Query: 95 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV
Sbjct: 121 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180
Query: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI
Sbjct: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 240
Query: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 274
RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA
Sbjct: 241 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 300
Query: 275 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVRITT 332
CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV SAESSSSMNSNTPLVRITT
Sbjct: 301 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 360
Query: 333 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 392
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK
Sbjct: 361 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 420
Query: 393 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 452
EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
Sbjct: 421 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 480
Query: 453 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 512
GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
Sbjct: 481 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 540
Query: 513 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 572
RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF
Sbjct: 541 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 600
Query: 573 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 632
GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT
Sbjct: 601 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 660
Query: 633 FKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSC 673
FKQLVEDLDRILTLTTNEE +S ++ + P + C
Sbjct: 661 FKQLVEDLDRILTLTTNEEEKKVSGAVDCHKPPCNPSHLPC 701
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 1311 bits (3392), Expect = 0.0
Identities = 643/672 (95%), Positives = 651/672 (96%), Gaps = 7/672 (1%)
Query: 38 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ
Sbjct: 153 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 212
Query: 98 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG
Sbjct: 213 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 272
Query: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK +G+N+++ E+ L+ NV
Sbjct: 273 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALF--NV 330
Query: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLP---APGREKEITASPDYLEIAIYCIGVFLIA 274
T DAGEY C N IG + SAWLTVLP APGREKEITASPDYLEIAIYCIGVFLIA
Sbjct: 331 TEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIA 390
Query: 275 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVRITT 332
CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV SAESSSSMNSNTPLVRITT
Sbjct: 391 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 450
Query: 333 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 392
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK
Sbjct: 451 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 510
Query: 393 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 452
EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
Sbjct: 511 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 570
Query: 453 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 512
GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
Sbjct: 571 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 630
Query: 513 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 572
RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF
Sbjct: 631 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 690
Query: 573 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 632
GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT
Sbjct: 691 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 750
Query: 633 FKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCL 692
FKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCL
Sbjct: 751 FKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCL 810
Query: 693 PQYPHINGSVKT 704
PQYPHINGSVKT
Sbjct: 811 PQYPHINGSVKT 822
Score = 94.4 bits (233), Expect = 3e-19
Identities = 78/273 (28%), Positives = 114/273 (41%), Gaps = 52/273 (19%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE P T + + ++ ++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58
Query: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117
+ RC + W K+G +R IG Y L ++ P D G Y C
Sbjct: 59 EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108
Query: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152
S + ++V + R+P+ + +
Sbjct: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168
Query: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
V+F C + P ++W+ KNG ++ + + G ++ L
Sbjct: 169 VPAANTVKFRCPAGGNPMPTMRWL----KNGKEFKQEH-------RIGGYKVRNQHWS-L 216
Query: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
+ +V D G YTC+ N G H+ L V+
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 1250 bits (3234), Expect = 0.0
Identities = 625/681 (91%), Positives = 633/681 (92%), Gaps = 33/681 (4%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGA---------------------- 38
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE A
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 39 ----PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV
Sbjct: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 120
Query: 95 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV
Sbjct: 121 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180
Query: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK +G+N+++ E+ L+
Sbjct: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALF- 239
Query: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP---APGREKEITASPDYLEIAIYCIGVF 271
NVT DAGEY C N IG + SAWLTVLP APGREKEITASPDYLEIAIYCIGVF
Sbjct: 240 -NVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVF 298
Query: 272 LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVR 329
LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV SAESSSSMNSNTPLVR
Sbjct: 299 LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 358
Query: 330 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 389
ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD
Sbjct: 359 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 418
Query: 390 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 449
KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY
Sbjct: 419 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 478
Query: 450 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 509
ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD
Sbjct: 479 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 538
Query: 510 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 569
LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV
Sbjct: 539 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 598
Query: 570 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 629
WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ
Sbjct: 599 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 658
Query: 630 RPTFKQLVEDLDRILTLTTNE 650
RPTFKQLVEDLDRILTLTTNE
Sbjct: 659 RPTFKQLVEDLDRILTLTTNE 679
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 1195 bits (3091), Expect = 0.0
Identities = 589/618 (95%), Positives = 597/618 (96%), Gaps = 7/618 (1%)
Query: 38 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ
Sbjct: 153 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 212
Query: 98 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG
Sbjct: 213 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 272
Query: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK +G+N+++ E+ L+ NV
Sbjct: 273 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALF--NV 330
Query: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLP---APGREKEITASPDYLEIAIYCIGVFLIA 274
T DAGEY C N IG + SAWLTVLP APGREKEITASPDYLEIAIYCIGVFLIA
Sbjct: 331 TEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIA 390
Query: 275 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVRITT 332
CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV SAESSSSMNSNTPLVRITT
Sbjct: 391 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 450
Query: 333 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 392
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK
Sbjct: 451 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 510
Query: 393 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 452
EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
Sbjct: 511 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 570
Query: 453 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 512
GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
Sbjct: 571 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 630
Query: 513 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 572
RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF
Sbjct: 631 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 690
Query: 573 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 632
GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT
Sbjct: 691 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 750
Query: 633 FKQLVEDLDRILTLTTNE 650
FKQLVEDLDRILTLTTNE
Sbjct: 751 FKQLVEDLDRILTLTTNE 768
Score = 94.4 bits (233), Expect = 3e-19
Identities = 78/273 (28%), Positives = 114/273 (41%), Gaps = 52/273 (19%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE P T + + ++ ++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58
Query: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117
+ RC + W K+G +R IG Y L ++ P D G Y C
Sbjct: 59 EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108
Query: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152
S + ++V + R+P+ + +
Sbjct: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168
Query: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
V+F C + P ++W+ KNG ++ + + G ++ L
Sbjct: 169 VPAANTVKFRCPAGGNPMPTMRWL----KNGKEFKQEH-------RIGGYKVRNQHWS-L 216
Query: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
+ +V D G YTC+ N G H+ L V+
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 1109 bits (2868), Expect = 0.0
Identities = 547/731 (74%), Positives = 615/731 (84%), Gaps = 30/731 (4%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVE-----------------------DTTLEPEG 37
M SW + V+ ATL ARPS +L E D T
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
Query: 38 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR
Sbjct: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120
Query: 98 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G
Sbjct: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 180
Query: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
+VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV
Sbjct: 181 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 240
Query: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV 277
+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G FLI+CMV
Sbjct: 241 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 300
Query: 278 VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVRITTRLS 335
+VI+ +MK+ TKK DF SQ AVHKL K IPLRRQV SA+SS+SMNS LVR +RLS
Sbjct: 301 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLS 359
Query: 336 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 395
S+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP
Sbjct: 360 SSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 418
Query: 396 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 455
VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 419 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 478
Query: 456 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 515
REYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNV
Sbjct: 479 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 538
Query: 516 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 575
LVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL
Sbjct: 539 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 598
Query: 576 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 635
+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQ
Sbjct: 599 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 658
Query: 636 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQ 694
LVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP+
Sbjct: 659 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 718
Query: 695 YPH--INGSVK 703
+P NG +K
Sbjct: 719 HPAQLANGGLK 729
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 1107 bits (2863), Expect = 0.0
Identities = 546/733 (74%), Positives = 614/733 (83%), Gaps = 32/733 (4%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEG----------------------- 37
M SW + V+ ATL ARPS +L E L
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
Query: 38 --APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVR 95
APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR
Sbjct: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
Query: 96 NQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV 155
WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +
Sbjct: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 180
Query: 156 GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIR 215
G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++R
Sbjct: 181 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLR 240
Query: 216 NVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIAC 275
NV+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G FLI+C
Sbjct: 241 NVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISC 300
Query: 276 MVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVRITTR 333
MV +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQV SA+SS+SMNS LVR +R
Sbjct: 301 MVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSR 359
Query: 334 LSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKE 393
LSS+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP
Sbjct: 360 LSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNR 418
Query: 394 AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 453
VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG
Sbjct: 419 VTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 478
Query: 454 NLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAAR 513
NLREYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAAR
Sbjct: 479 NLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAAR 538
Query: 514 NVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 573
NVLVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFG
Sbjct: 539 NVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFG 598
Query: 574 VLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF 633
VL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTF
Sbjct: 599 VLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF 658
Query: 634 KQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCL 692
KQLVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCL
Sbjct: 659 KQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCL 718
Query: 693 PQYPH--INGSVK 703
P++P NG +K
Sbjct: 719 PRHPAQLANGGLK 731
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 1103 bits (2853), Expect = 0.0
Identities = 534/679 (78%), Positives = 599/679 (88%), Gaps = 7/679 (1%)
Query: 30 DTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRI 89
D T APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRI
Sbjct: 142 DNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRI 201
Query: 90 GGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPA 149
GGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPA
Sbjct: 202 GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPA 261
Query: 150 NASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEI 209
N + +G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+
Sbjct: 262 NKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM 321
Query: 210 EVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIG 269
EVL++RNV+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G
Sbjct: 322 EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTG 381
Query: 270 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPL 327
FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQV SA+SS+SMNS L
Sbjct: 382 AFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLL 441
Query: 328 VRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 387
VR +RLSS+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+D
Sbjct: 442 VR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLD 499
Query: 388 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 447
KDKP VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIV
Sbjct: 500 KDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 559
Query: 448 EYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIH 507
EYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIH
Sbjct: 560 EYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIH 619
Query: 508 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 567
RDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQS
Sbjct: 620 RDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQS 679
Query: 568 DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVP 627
DVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVP
Sbjct: 680 DVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVP 739
Query: 628 SQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPM 686
SQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+
Sbjct: 740 SQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPL 799
Query: 687 PYEPCLPQYPH--INGSVK 703
P EPCLP++P NG +K
Sbjct: 800 PEEPCLPRHPAQLANGGLK 818
Score = 51.6 bits (122), Expect = 2e-06
Identities = 62/275 (22%), Positives = 104/275 (37%), Gaps = 59/275 (21%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
M SW + V+ ATL ARPS +L E +P GAP +E V + +
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAP-------VEVESFLVHPGDLL 51
Query: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118
+ RC + + ++ WL++G + + +R I G +V ++ VP+D G Y CV
Sbjct: 52 QLRCRLRDD-VQSINWLRDGVQLAESNRTRITGEEVE-------VQDSVPADSGLYACVT 103
Query: 119 ENEYGSINHTYHLDVVERSPH----------------------RPILQAGLPANA----- 151
+ GS + ++V + P P+
Sbjct: 104 SSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKL 163
Query: 152 -STVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIE 210
+ V+F C P ++W+ KNG ++ PD + G
Sbjct: 164 HAVPAAKTVKFKCPSSGTPNPTLRWL----KNGKEFKPDH-------RIGGYKVRYATWS 212
Query: 211 VLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
++ + +V D G YTC+ N G H+ L V+
Sbjct: 213 II-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVV 246
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 1102 bits (2851), Expect = 0.0
Identities = 532/671 (79%), Positives = 597/671 (88%), Gaps = 7/671 (1%)
Query: 38 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR
Sbjct: 152 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 211
Query: 98 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G
Sbjct: 212 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 271
Query: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
+VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV
Sbjct: 272 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331
Query: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV 277
+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G FLI+CMV
Sbjct: 332 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 391
Query: 278 VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVRITTRLS 335
+VI+ +MK+ TKK DF SQ AVHKL K IPLRRQV SA+SS+SMNS LVR +RLS
Sbjct: 392 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLS 450
Query: 336 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 395
S+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP
Sbjct: 451 SSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 509
Query: 396 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 455
VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 510 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 569
Query: 456 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 515
REYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNV
Sbjct: 570 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 629
Query: 516 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 575
LVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL
Sbjct: 630 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 689
Query: 576 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 635
+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQ
Sbjct: 690 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 749
Query: 636 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQ 694
LVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP+
Sbjct: 750 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 809
Query: 695 YPH--INGSVK 703
+P NG +K
Sbjct: 810 HPAQLANGGLK 820
Score = 52.0 bits (123), Expect = 2e-06
Identities = 64/277 (23%), Positives = 105/277 (37%), Gaps = 61/277 (22%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
M SW + V+ ATL ARPS +L E +P GAP +E V + +
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAP-------VEVESFLVHPGDLL 51
Query: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118
+ RC + + ++ WL++G + + +R I G +V ++ VP+D G Y CV
Sbjct: 52 QLRCRLRDD-VQSINWLRDGVQLAESNRTRITGEEVE-------VQDSVPADSGLYACVT 103
Query: 119 ENEYGSINHTYHLDVVERSPH--------------------RPILQAGLPANAS------ 152
+ GS + ++V + P +P P S
Sbjct: 104 SSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEK 163
Query: 153 ----TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKE 208
V+F C P ++W+ KNG ++ PD + G
Sbjct: 164 KLHAVPAAKTVKFKCPSSGTPNPTLRWL----KNGKEFKPDH-------RIGGYKVRYAT 212
Query: 209 IEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
++ + +V D G YTC+ N G H+ L V+
Sbjct: 213 WSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVV 248
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 1018 bits (2631), Expect = 0.0
Identities = 501/666 (75%), Positives = 569/666 (85%), Gaps = 13/666 (1%)
Query: 29 EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
EDT ++ GAPYWT E+M+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHR
Sbjct: 142 EDTGVDT-GAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHR 200
Query: 89 IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLP 148
IGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLP
Sbjct: 201 IGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLP 260
Query: 149 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKE 208
AN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG PY+ VLK AG NTTDKE
Sbjct: 261 ANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKE 320
Query: 209 IEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPD----YLEIA 264
+EVL + NVTFEDAGEYTCLAGNSIG S HSAWL VLPA E+E+ + + Y I
Sbjct: 321 LEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPA---EEELVEADEAGSVYAGIL 377
Query: 265 IYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSN 324
Y +G FL +V V LCR+++ KK P VHK++ R PL+RQVS ES++SM+SN
Sbjct: 378 SYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-RFPLKRQVSLESNASMSSN 434
Query: 325 TPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAV 384
TPLVRI RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+
Sbjct: 435 TPLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAI 492
Query: 385 GIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLY 444
GIDKD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLY
Sbjct: 493 GIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLY 552
Query: 445 VIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQK 504
V+VEYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQK
Sbjct: 553 VLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQK 612
Query: 505 CIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYT 564
CIHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYT
Sbjct: 613 CIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYT 672
Query: 565 HQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWH 624
HQSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWH
Sbjct: 673 HQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWH 732
Query: 625 AVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPD 684
A PSQRPTFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D
Sbjct: 733 AAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHD 792
Query: 685 PMPYEP 690
+P P
Sbjct: 793 LLPPAP 798
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 1016 bits (2627), Expect = 0.0
Identities = 535/734 (72%), Positives = 573/734 (78%), Gaps = 55/734 (7%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE P T + + ++ ++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58
Query: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117
+ RC + W K+G +R IG Y L ++ P D G Y C
Sbjct: 59 EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108
Query: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152
S + ++V + R+P+ + +
Sbjct: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168
Query: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
V+F C + P ++W+K NG ++ + + G ++ ++
Sbjct: 169 VPAANTVKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI 217
Query: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFL 272
+ +V D G YTC+ N G H+ L V+ APGREKEITASPDYLEIAIYCIGVFL
Sbjct: 218 -MESVVPSDKGNYTCVVENEYGSINHTYHLDVV-APGREKEITASPDYLEIAIYCIGVFL 275
Query: 273 IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVRI 330
IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV SAESSSSMNSNTPLVRI
Sbjct: 276 IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI 335
Query: 331 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 390
TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK
Sbjct: 336 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 395
Query: 391 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 450
PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA
Sbjct: 396 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 455
Query: 451 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 510
SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL
Sbjct: 456 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 515
Query: 511 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 570
AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW
Sbjct: 516 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 575
Query: 571 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 630
SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR
Sbjct: 576 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 635
Query: 631 PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 690
PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP
Sbjct: 636 PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 695
Query: 691 CLPQYPHINGSVKT 704
CLPQYPHINGSVKT
Sbjct: 696 CLPQYPHINGSVKT 709
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 1003 bits (2594), Expect = 0.0
Identities = 496/671 (73%), Positives = 560/671 (83%), Gaps = 44/671 (6%)
Query: 38 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR
Sbjct: 152 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 211
Query: 98 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G
Sbjct: 212 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 271
Query: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
+VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV
Sbjct: 272 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331
Query: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV 277
+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G FLI+CMV
Sbjct: 332 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 391
Query: 278 VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVRITTRLS 335
+VI+ +MK+ TKK DF SQ AVHKL K IPLRRQV SA+SS+SMNS LVR +RLS
Sbjct: 392 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLS 450
Query: 336 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 395
S+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP
Sbjct: 451 SSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 509
Query: 396 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 455
VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 510 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 569
Query: 456 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 515
REYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNV
Sbjct: 570 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 629
Query: 516 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 575
LVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL
Sbjct: 630 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 689
Query: 576 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 635
+WEIFTLGGSPYPG+PVEEL FKQ
Sbjct: 690 LWEIFTLGGSPYPGVPVEEL-------------------------------------FKQ 712
Query: 636 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQ 694
LVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP+
Sbjct: 713 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 772
Query: 695 YPH--INGSVK 703
+P NG +K
Sbjct: 773 HPAQLANGGLK 783
Score = 52.0 bits (123), Expect = 2e-06
Identities = 64/277 (23%), Positives = 105/277 (37%), Gaps = 61/277 (22%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
M SW + V+ ATL ARPS +L E +P GAP +E V + +
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAP-------VEVESFLVHPGDLL 51
Query: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118
+ RC + + ++ WL++G + + +R I G +V ++ VP+D G Y CV
Sbjct: 52 QLRCRLRDD-VQSINWLRDGVQLAESNRTRITGEEVE-------VQDSVPADSGLYACVT 103
Query: 119 ENEYGSINHTYHLDVVERSPH--------------------RPILQAGLPANAS------ 152
+ GS + ++V + P +P P S
Sbjct: 104 SSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEK 163
Query: 153 ----TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKE 208
V+F C P ++W+ KNG ++ PD + G
Sbjct: 164 KLHAVPAAKTVKFKCPSSGTPNPTLRWL----KNGKEFKPDH-------RIGGYKVRYAT 212
Query: 209 IEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
++ + +V D G YTC+ N G H+ L V+
Sbjct: 213 WSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVV 248
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 962 bits (2487), Expect = 0.0
Identities = 476/666 (71%), Positives = 553/666 (83%), Gaps = 11/666 (1%)
Query: 29 EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
EDT ++ GAPYWT E+M+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHR
Sbjct: 142 EDTGVDT-GAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHR 200
Query: 89 IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLP 148
IGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLP
Sbjct: 201 IGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLP 260
Query: 149 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKE 208
AN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG PY+ VLK+ + + +
Sbjct: 261 ANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEAD 320
Query: 209 IEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPD----YLEIA 264
+ L + NV+ D GEY C A N IG++ + WL+V E+E+ + + Y I
Sbjct: 321 VR-LRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGIL 379
Query: 265 IYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSN 324
Y +G FL +V V LCR+++ KK P VHK++ R PL+RQVS ES++SM+SN
Sbjct: 380 SYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-RFPLKRQVSLESNASMSSN 436
Query: 325 TPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAV 384
TPLVRI RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+
Sbjct: 437 TPLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAI 494
Query: 385 GIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLY 444
GIDKD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLY
Sbjct: 495 GIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLY 554
Query: 445 VIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQK 504
V+VEYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQK
Sbjct: 555 VLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQK 614
Query: 505 CIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYT 564
CIHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYT
Sbjct: 615 CIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYT 674
Query: 565 HQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWH 624
HQSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWH
Sbjct: 675 HQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWH 734
Query: 625 AVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPD 684
A PSQRPTFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D
Sbjct: 735 AAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHD 794
Query: 685 PMPYEP 690
+P P
Sbjct: 795 LLPPAP 800
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 876 bits (2263), Expect = 0.0
Identities = 482/739 (65%), Positives = 526/739 (71%), Gaps = 69/739 (9%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE P T + + ++ ++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58
Query: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117
+ RC + W K+G +R IG Y L ++ P D G Y C
Sbjct: 59 EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108
Query: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152
S + ++V + R+P+ + +
Sbjct: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168
Query: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
V+F C + P ++W+K NG ++ + + G ++ ++
Sbjct: 169 VPAANTVKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI 217
Query: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP-APGREKEITASPDYLEIAI-----Y 266
+ +V D G YTC+ N G H+ L V+ +P R P + +
Sbjct: 218 -MESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEF 276
Query: 267 CIGVFLIACMVVTVILCRMKNTTKK-PDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNT 325
V+ A + I KN +K PD V K VSAESSSSMNSNT
Sbjct: 277 VCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK----------VSAESSSSMNSNT 326
Query: 326 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 385
PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG
Sbjct: 327 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 386
Query: 386 IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV 445
IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV
Sbjct: 387 IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV 446
Query: 446 IVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKC 505
IVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKC
Sbjct: 447 IVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKC 506
Query: 506 IHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTH 565
IHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTH
Sbjct: 507 IHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTH 566
Query: 566 QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHA 625
QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHA
Sbjct: 567 QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHA 626
Query: 626 VPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDP 685
VPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDP
Sbjct: 627 VPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDP 686
Query: 686 MPYEPCLPQYPHINGSVKT 704
MPYEPCLPQYPHINGSVKT
Sbjct: 687 MPYEPCLPQYPHINGSVKT 705
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 867 bits (2241), Expect = 0.0
Identities = 436/658 (66%), Positives = 524/658 (79%), Gaps = 17/658 (2%)
Query: 35 PEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
P+ APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++
Sbjct: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRL 202
Query: 95 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + V
Sbjct: 203 RHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV 262
Query: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
VG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK A +N++ E+EVLY+
Sbjct: 263 VGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYL 320
Query: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEIT---ASPD--YLEIAIYCIG 269
RNV+ EDAGEYTCLAGNSIG+S+ SAWLTVLP E++ T A+P+ Y +I +Y G
Sbjct: 321 RNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP----EEDPTWTAAAPEARYTDIILYASG 376
Query: 270 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVR 329
+A +++ L R + + PA + R PL RQ S ES SS S++ LVR
Sbjct: 377 SLALAVLLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVR 434
Query: 330 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 389
RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D
Sbjct: 435 -GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPA 492
Query: 390 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 449
+P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE
Sbjct: 493 RPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVEC 552
Query: 450 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 509
A+KGNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIHRD
Sbjct: 553 AAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRD 612
Query: 510 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 569
LAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDV
Sbjct: 613 LAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDV 672
Query: 570 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 629
WSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQ
Sbjct: 673 WSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQ 732
Query: 630 RPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 687
RPTFKQLVE LD++L L +EEYLDL YSPS D S+CSS DSVFS DP+P
Sbjct: 733 RPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDASSTCSS-SDSVFSHDPLP 788
Score = 44.7 bits (104), Expect = 3e-04
Identities = 58/246 (23%), Positives = 88/246 (35%), Gaps = 48/246 (19%)
Query: 24 SFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEF 83
S E+ LEP AP + E+ E+ L V V+ C G W K G
Sbjct: 21 SLEASEEVELEPCLAP---SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRL 73
Query: 84 KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH---------TYHLDVV 134
R+ G++ R L + S +P D G Y C+ + + T D
Sbjct: 74 APAGRVRGWRGR-----LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDE 128
Query: 135 ERSPHR-PILQAGLPANA--------------STVVGGDVEFVCKVYSDAQPHIQWIKHV 179
+ HR P + P A + G V+F C + P I+W+K
Sbjct: 129 DPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK-- 186
Query: 180 EKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHS 239
DG + + G+ + L + +V D G YTCL N++G ++
Sbjct: 187 ---------DGQAFHGENRIGGIRLRHQHWS-LVMESVVPSDRGTYTCLVENAVGSIRYN 236
Query: 240 AWLTVL 245
L VL
Sbjct: 237 YLLDVL 242
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 867 bits (2241), Expect = 0.0
Identities = 436/658 (66%), Positives = 524/658 (79%), Gaps = 17/658 (2%)
Query: 35 PEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
P+ APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++
Sbjct: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRL 202
Query: 95 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + V
Sbjct: 203 RHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV 262
Query: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
VG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK A +N++ E+EVLY+
Sbjct: 263 VGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYL 320
Query: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEIT---ASPD--YLEIAIYCIG 269
RNV+ EDAGEYTCLAGNSIG+S+ SAWLTVLP E++ T A+P+ Y +I +Y G
Sbjct: 321 RNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP----EEDPTWTAAAPEARYTDIILYASG 376
Query: 270 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVR 329
+A +++ L R + + PA + R PL RQ S ES SS S++ LVR
Sbjct: 377 SLALAVLLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVR 434
Query: 330 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 389
RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D
Sbjct: 435 -GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPA 492
Query: 390 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 449
+P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE
Sbjct: 493 RPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVEC 552
Query: 450 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 509
A+KGNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIHRD
Sbjct: 553 AAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRD 612
Query: 510 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 569
LAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDV
Sbjct: 613 LAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDV 672
Query: 570 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 629
WSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQ
Sbjct: 673 WSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQ 732
Query: 630 RPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 687
RPTFKQLVE LD++L L +EEYLDL YSPS D S+CSS DSVFS DP+P
Sbjct: 733 RPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDASSTCSS-SDSVFSHDPLP 788
Score = 44.7 bits (104), Expect = 3e-04
Identities = 58/246 (23%), Positives = 88/246 (35%), Gaps = 48/246 (19%)
Query: 24 SFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEF 83
S E+ LEP AP + E+ E+ L V V+ C G W K G
Sbjct: 21 SLEASEEVELEPCLAP---SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRL 73
Query: 84 KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH---------TYHLDVV 134
R+ G++ R L + S +P D G Y C+ + + T D
Sbjct: 74 APAGRVRGWRGR-----LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDE 128
Query: 135 ERSPHR-PILQAGLPANA--------------STVVGGDVEFVCKVYSDAQPHIQWIKHV 179
+ HR P + P A + G V+F C + P I+W+K
Sbjct: 129 DPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK-- 186
Query: 180 EKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHS 239
DG + + G+ + L + +V D G YTCL N++G ++
Sbjct: 187 ---------DGQAFHGENRIGGIRLRHQHWS-LVMESVVPSDRGTYTCLVENAVGSIRYN 236
Query: 240 AWLTVL 245
L VL
Sbjct: 237 YLLDVL 242
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 847 bits (2187), Expect = 0.0
Identities = 428/653 (65%), Positives = 504/653 (77%), Gaps = 47/653 (7%)
Query: 35 PEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
P+ APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++
Sbjct: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRL 202
Query: 95 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + V
Sbjct: 203 RHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV 262
Query: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
VG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK A +N++ E+EVLY+
Sbjct: 263 VGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYL 320
Query: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 274
RNV+ EDAGEYTCLAGNSIG+S+ SAWLTVLP GR +T D L A
Sbjct: 321 RNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHLTC--DSLTPA---------- 368
Query: 275 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRL 334
TK P Q S ES SS S++ LVR RL
Sbjct: 369 ------------GRTKSPTL-----------------QFSLESGSSGKSSSSLVR-GVRL 398
Query: 335 SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 394
SS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D +P +A
Sbjct: 399 SSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQA 457
Query: 395 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 454
TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KGN
Sbjct: 458 STVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGN 517
Query: 455 LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN 514
LRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIHRDLAARN
Sbjct: 518 LREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARN 577
Query: 515 VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 574
VLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDVWSFG+
Sbjct: 578 VLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGI 637
Query: 575 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 634
L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTFK
Sbjct: 638 LLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFK 697
Query: 635 QLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 687
QLVE LD++L L +EEYLDL YSPS D S+CSS DSVFS DP+P
Sbjct: 698 QLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDASSTCSS-SDSVFSHDPLP 748
Score = 44.7 bits (104), Expect = 3e-04
Identities = 58/246 (23%), Positives = 88/246 (35%), Gaps = 48/246 (19%)
Query: 24 SFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEF 83
S E+ LEP AP + E+ E+ L V V+ C G W K G
Sbjct: 21 SLEASEEVELEPCLAP---SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRL 73
Query: 84 KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH---------TYHLDVV 134
R+ G++ R L + S +P D G Y C+ + + T D
Sbjct: 74 APAGRVRGWRGR-----LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDE 128
Query: 135 ERSPHR-PILQAGLPANA--------------STVVGGDVEFVCKVYSDAQPHIQWIKHV 179
+ HR P + P A + G V+F C + P I+W+K
Sbjct: 129 DPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK-- 186
Query: 180 EKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHS 239
DG + + G+ + L + +V D G YTCL N++G ++
Sbjct: 187 ---------DGQAFHGENRIGGIRLRHQHWS-LVMESVVPSDRGTYTCLVENAVGSIRYN 236
Query: 240 AWLTVL 245
L VL
Sbjct: 237 YLLDVL 242
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 642 bits (1657), Expect = 0.0
Identities = 343/538 (63%), Positives = 396/538 (73%), Gaps = 29/538 (5%)
Query: 159 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 218
V F C + P I W+K NG ++ + + G+ ++ L + +V
Sbjct: 172 VRFRCPAAGNPTPSISWLK----NGREFRGEH-------RIGGIKLRHQQWS-LVMESVV 219
Query: 219 FEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVV 278
D G YTC+ N G + L VL + A + A+ V C V
Sbjct: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEF-HCKVY 278
Query: 279 TVI------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITT 332
+ L ++ K P V L +VS ES++SM+SNTPLVRI
Sbjct: 279 SDAQPHIQWLKHVEVNGSKVGPDGTPYVTVL--------KVSLESNASMSSNTPLVRIA- 329
Query: 333 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 392
RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+
Sbjct: 330 RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAA 388
Query: 393 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 452
+ VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+K
Sbjct: 389 KPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK 448
Query: 453 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 512
GNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAA
Sbjct: 449 GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAA 508
Query: 513 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 572
RNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF
Sbjct: 509 RNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 568
Query: 573 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 632
GVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPT
Sbjct: 569 GVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT 628
Query: 633 FKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 690
FKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 629 FKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 686
Score = 275 bits (702), Expect = 1e-73
Identities = 126/172 (73%), Positives = 148/172 (86%), Gaps = 1/172 (0%)
Query: 29 EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
EDT ++ GAPYWT E+M+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHR
Sbjct: 142 EDTGVDT-GAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHR 200
Query: 89 IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLP 148
IGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLP
Sbjct: 201 IGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLP 260
Query: 149 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAA 200
AN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG PY+ VLK +
Sbjct: 261 ANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVS 312
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 330 bits (846), Expect = 3e-90
Identities = 180/384 (46%), Positives = 238/384 (61%), Gaps = 29/384 (7%)
Query: 301 HKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPE 353
HK + P+ SS+ M P SS+ A P L V +++ E
Sbjct: 661 HKFAHKPPI-------SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILE 713
Query: 354 DPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLS 412
DPKWEFPR L LGK LGEG FG+VV A A + K + TVAVKMLK++A+ +L
Sbjct: 714 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELR 770
Query: 413 DLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--- 469
DL+SE ++K + H ++I L GAC+QDGPL +IVEYA G+LR +LR R G Y
Sbjct: 771 DLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGS 829
Query: 470 -----SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMK 524
S ++ E +T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MK
Sbjct: 830 GGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMK 889
Query: 525 IADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGG 584
I+DFGL+RD+ D Y K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG
Sbjct: 890 ISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGG 949
Query: 585 SPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 644
+PYPGIP E LF LLK GHRM++P NC+ E+Y +M CW P +RP F + +DL+++
Sbjct: 950 NPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM- 1008
Query: 645 TLTTNEEYLDLSQPLEQYSPSYPD 668
+ +YLDL+ S Y D
Sbjct: 1009 -MVKRRDYLDLAASTPSDSLIYDD 1031
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 330 bits (846), Expect = 3e-90
Identities = 180/384 (46%), Positives = 238/384 (61%), Gaps = 29/384 (7%)
Query: 301 HKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPE 353
HK + P+ SS+ M P SS+ A P L V +++ E
Sbjct: 661 HKFAHKPPI-------SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILE 713
Query: 354 DPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLS 412
DPKWEFPR L LGK LGEG FG+VV A A + K + TVAVKMLK++A+ +L
Sbjct: 714 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELR 770
Query: 413 DLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--- 469
DL+SE ++K + H ++I L GAC+QDGPL +IVEYA G+LR +LR R G Y
Sbjct: 771 DLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGS 829
Query: 470 -----SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMK 524
S ++ E +T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MK
Sbjct: 830 GGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMK 889
Query: 525 IADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGG 584
I+DFGL+RD+ D Y K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG
Sbjct: 890 ISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGG 949
Query: 585 SPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 644
+PYPGIP E LF LLK GHRM++P NC+ E+Y +M CW P +RP F + +DL+++
Sbjct: 950 NPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM- 1008
Query: 645 TLTTNEEYLDLSQPLEQYSPSYPD 668
+ +YLDL+ S Y D
Sbjct: 1009 -MVKRRDYLDLAASTPSDSLIYDD 1031
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 329 bits (843), Expect = 6e-90
Identities = 240/642 (37%), Positives = 319/642 (49%), Gaps = 124/642 (19%)
Query: 101 LIMESVVPS--DKGNYTCVVENEYGSINHTY--HLDVVERSPHRPILQAGLPANASTVVG 156
LIME S D+G+Y C+ ++ H L V+ER P + L N +T +G
Sbjct: 625 LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIG 681
Query: 157 GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 216
+E C + P I W K N + G+ VLK N T IR
Sbjct: 682 ESIEVSCTASGNPPPQIMWFKD---NETLVEDSGI----VLKDGNRNLT--------IRR 726
Query: 217 VTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACM 276
V ED G YTC A + +G + A+ + A + LEI I +G +IA M
Sbjct: 727 VRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTN--------LEIIIL-VGTAVIA-M 776
Query: 277 VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSS 336
++L + T K+ + + P PL RL
Sbjct: 777 FFWLLLVIILRTVKRANGGELKTGYLSIVMDP--------------DELPLDEHCERLPY 822
Query: 337 TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVT 396
A KWEFPRD+L LGKPLG G FGQV+ A+A GIDK T
Sbjct: 823 DAS----------------KWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCR--T 864
Query: 397 VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEYASKGNL 455
VAVKMLK+ AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE+ GNL
Sbjct: 865 VAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNL 924
Query: 456 REYLRARRPPGMEYS-----------------YDINR----------------------- 475
YLR++R + Y D+ R
Sbjct: 925 STYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLS 984
Query: 476 -VPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKI 525
V EE+ +T + L+ ++Q+A+GME+LAS+KCIHRDLAARN+L++E NV+KI
Sbjct: 985 DVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKI 1044
Query: 526 ADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGS 585
DFGLARDI Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVL+WEIF+LG S
Sbjct: 1045 CDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGAS 1104
Query: 586 PYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 644
PYPG+ ++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LVE L +L
Sbjct: 1105 PYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLL 1164
Query: 645 TLTTNEE-----YLDLSQPL---EQYSPSYPDTRSSCSSGDD 678
++ L +S+ L E S P + SC ++
Sbjct: 1165 QANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEE 1206
Score = 41.6 bits (96), Expect = 0.003
Identities = 35/124 (28%), Positives = 53/124 (42%), Gaps = 9/124 (7%)
Query: 61 KFRCPAG--GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118
+ R PA G P P ++W KNG + H I + H IME V D GNYT ++
Sbjct: 347 RVRIPAKYLGYPPPEIKWYKNGIPLESNHTI-----KAGHVLTIME-VSERDTGNYTVIL 400
Query: 119 ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQP-HIQWIK 177
N ++ + +V P + ++ + S G C VY+ P HI W
Sbjct: 401 TNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYW 460
Query: 178 HVEK 181
+E+
Sbjct: 461 QLEE 464
Score = 37.0 bits (84), Expect = 0.063
Identities = 27/112 (24%), Positives = 51/112 (45%), Gaps = 12/112 (10%)
Query: 5 GRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRC 64
G ++CL A + +V T+ AP T T +E + ++ +++ C
Sbjct: 638 GDYVCL-----AQDRKTKKRHCVVRQLTVLERVAP--TITGNLENQTTSI--GESIEVSC 688
Query: 65 PAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTC 116
A GNP P + W K+ + ++ G +++ + +L + V D+G YTC
Sbjct: 689 TASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNLTIRRVRKEDEGLYTC 737
Score = 35.8 bits (81), Expect = 0.14
Identities = 35/136 (25%), Positives = 54/136 (39%), Gaps = 24/136 (17%)
Query: 100 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ--AGLPANASTVVGG 157
+L ++ V SD+G YTC + + ++ + V E+ P + +G+ + VG
Sbjct: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
Query: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
V K P I+W K+ G+P N T K VL I V
Sbjct: 347 RVRIPAKYLGYPPPEIKWYKN-----------GIPLES-------NHTIKAGHVLTIMEV 388
Query: 218 TFEDAGEYTCLAGNSI 233
+ D G YT + N I
Sbjct: 389 SERDTGNYTVILTNPI 404
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 321 bits (823), Expect = 1e-87
Identities = 217/612 (35%), Positives = 307/612 (50%), Gaps = 120/612 (19%)
Query: 100 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 159
+L + +V D G Y C N Y ++ R P L L ++ + +
Sbjct: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISSST 678
Query: 160 EFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTF 219
C +P I W K+ K + G ++ G +T L+I VT
Sbjct: 679 TLDCHANGVPEPQITWFKNNHKIQQEPG--------IILGPGSST-------LFIERVTE 723
Query: 220 EDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVT 279
ED G Y C A N G SA+LTV + ++ + + + C+ L +++T
Sbjct: 724 EDEGVYHCKATNQKGSVESSAYLTVQGTSDK-----SNLELITLTCTCVAATLF-WLLLT 777
Query: 280 VILCRMKNTTK--KPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSST 337
+ + +MK ++ K D+ S + +PL Q
Sbjct: 778 LFIRKMKRSSSEIKTDYLS---IIMDPDEVPLDEQCE----------------------- 811
Query: 338 ADTPMLAGVSEYELPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVT 396
LP D KWEF R++L LGK LG G FG+VV A A GI K T
Sbjct: 812 ------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR--T 857
Query: 397 VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNL 455
VAVKMLK+ AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY GNL
Sbjct: 858 VAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNL 917
Query: 456 REYLRARRP--------------------PGMEYSY----------------------DI 473
YL+++R PG+E +
Sbjct: 918 SNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSL 977
Query: 474 NRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMK 524
+ V EE+ +T +DL+S ++Q+ARGME+L+S+KCIHRDLAARN+L++ENNV+K
Sbjct: 978 SDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVK 1037
Query: 525 IADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLG 583
I DFGLARDI N DY +K RLP+KWMAPE++FD++Y+ +SDVWS+GVL+WEIF+LG
Sbjct: 1038 ICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLG 1096
Query: 584 GSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 642
GSPYPG+ ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE L
Sbjct: 1097 GSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGD 1156
Query: 643 ILTLTTNEEYLD 654
+L ++ D
Sbjct: 1157 LLQANVQQDGKD 1168
Score = 45.8 bits (107), Expect = 1e-04
Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 7/105 (6%)
Query: 29 EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
++ T+ + APY H V +++ C A G P P + W KN + +QE
Sbjct: 651 KEITIRDQEAPYLLRNLSD----HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE-- 704
Query: 89 IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDV 133
G + +L +E V D+G Y C N+ GS+ + +L V
Sbjct: 705 -PGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTV 748
Score = 43.1 bits (100), Expect = 9e-04
Identities = 38/160 (23%), Positives = 66/160 (41%), Gaps = 11/160 (6%)
Query: 23 PSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKE 82
PSF V +T++ + T + ++ L V + + P P + WLK+G
Sbjct: 317 PSFKSV-NTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG-- 373
Query: 83 FKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVERSP 138
+ Y R +SLI++ V D GNYT ++ N + ++ T ++V +
Sbjct: 374 LPATEKSARYLTRG--YSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIY 431
Query: 139 HRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKH 178
+ + + P A +G C Y QP I+W H
Sbjct: 432 EKAV--SSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWH 469
Score = 34.3 bits (77), Expect = 0.41
Identities = 47/179 (26%), Positives = 75/179 (41%), Gaps = 37/179 (20%)
Query: 101 LIMESVVPSDKGNYTCVVEN--EYGSINHTYHLD----VVERSPHRPILQAGLPANASTV 154
L ++ + DKG YTC V + + S+N + H+ + + + +L+ TV
Sbjct: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE--------TV 347
Query: 155 VGG-DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLY 213
G KV + P + W+K DGLP + K+A T L
Sbjct: 348 AGKRSYRLSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYS---LI 391
Query: 214 IRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL---PAPGREKEITASPDYLEIAIYCIG 269
I++VT EDAG YT L F + T++ EK +++ PD A+Y +G
Sbjct: 392 IKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPD---PALYPLG 447
>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
[Homo sapiens]
Length = 300
Score = 289 bits (739), Expect = 7e-78
Identities = 140/221 (63%), Positives = 161/221 (72%), Gaps = 23/221 (10%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVE-----------------------DTTLEPEG 37
M SW + V+ ATL ARPS +L E D T
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
Query: 38 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR
Sbjct: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120
Query: 98 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G
Sbjct: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 180
Query: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK 198
+VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK
Sbjct: 181 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 221
Score = 30.8 bits (68), Expect = 4.5
Identities = 22/87 (25%), Positives = 36/87 (41%), Gaps = 12/87 (13%)
Query: 159 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 218
V+F C P ++W+K NG ++ PD + G ++ + +V
Sbjct: 83 VKFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRYATWSII-MDSVV 130
Query: 219 FEDAGEYTCLAGNSIGISFHSAWLTVL 245
D G YTC+ N G H+ L V+
Sbjct: 131 PSDKGNYTCIVENEYGSINHTYQLDVV 157
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 289 bits (739), Expect = 7e-78
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 350 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 409
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 571 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 628
Query: 410 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 464
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 629 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 688
Query: 465 ---------------------------------PGMEY----------SYDINRVPEEQM 481
PG+ Y S I E +
Sbjct: 689 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 748
Query: 482 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 529
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 749 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 808
Query: 530 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 589
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 809 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 868
Query: 590 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 648
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 869 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 928
Query: 649 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 684
N Y +L+ +P+ +S S+ SS + D
Sbjct: 929 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 971
Score = 31.6 bits (70), Expect = 2.6
Identities = 32/136 (23%), Positives = 61/136 (44%), Gaps = 15/136 (11%)
Query: 100 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHR--PILQAGLPANASTVVGG 157
+L + S +D G + C N +GS N T L+VV++ P++ + N G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVND----GE 329
Query: 158 DVEFVCKVYSDAQP-HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 216
+V+ + + + +P H QWI ++ + + D Y K + + + + L++
Sbjct: 330 NVDLIVEYEAFPKPEHQQWI-YMNRTFTDKWED---YPKSENESNI----RYVSELHLTR 381
Query: 217 VTFEDAGEYTCLAGNS 232
+ + G YT L NS
Sbjct: 382 LKGTEGGTYTFLVSNS 397
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 289 bits (739), Expect = 7e-78
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 350 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 409
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632
Query: 410 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 464
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
Query: 465 ---------------------------------PGMEY----------SYDINRVPEEQM 481
PG+ Y S I E +
Sbjct: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752
Query: 482 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 529
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812
Query: 530 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 589
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872
Query: 590 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 648
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932
Query: 649 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 684
N Y +L+ +P+ +S S+ SS + D
Sbjct: 933 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 975
Score = 31.6 bits (70), Expect = 2.6
Identities = 32/136 (23%), Positives = 61/136 (44%), Gaps = 15/136 (11%)
Query: 100 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHR--PILQAGLPANASTVVGG 157
+L + S +D G + C N +GS N T L+VV++ P++ + N G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVND----GE 329
Query: 158 DVEFVCKVYSDAQP-HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 216
+V+ + + + +P H QWI ++ + + D Y K + + + + L++
Sbjct: 330 NVDLIVEYEAFPKPEHQQWI-YMNRTFTDKWED---YPKSENESNI----RYVSELHLTR 381
Query: 217 VTFEDAGEYTCLAGNS 232
+ + G YT L NS
Sbjct: 382 LKGTEGGTYTFLVSNS 397
>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
[Homo sapiens]
Length = 302
Score = 287 bits (734), Expect = 3e-77
Identities = 139/223 (62%), Positives = 160/223 (71%), Gaps = 25/223 (11%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEG----------------------- 37
M SW + V+ ATL ARPS +L E L
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
Query: 38 --APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVR 95
APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR
Sbjct: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
Query: 96 NQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV 155
WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +
Sbjct: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 180
Query: 156 GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK 198
G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK
Sbjct: 181 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 223
Score = 30.8 bits (68), Expect = 4.5
Identities = 22/87 (25%), Positives = 36/87 (41%), Gaps = 12/87 (13%)
Query: 159 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 218
V+F C P ++W+K NG ++ PD + G ++ + +V
Sbjct: 85 VKFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRYATWSII-MDSVV 132
Query: 219 FEDAGEYTCLAGNSIGISFHSAWLTVL 245
D G YTC+ N G H+ L V+
Sbjct: 133 PSDKGNYTCIVENEYGSINHTYQLDVV 159
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 244 bits (624), Expect = 2e-64
Identities = 134/295 (45%), Positives = 186/295 (63%), Gaps = 10/295 (3%)
Query: 362 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 421
+ +T +GEG FGQV+ A I KD K + A+KMLK+ A+E D D E+E++
Sbjct: 837 EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891
Query: 422 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 481
+G H NIINLLGAC G LY+ +EYA GNL ++LR R + ++ +
Sbjct: 892 CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951
Query: 482 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 541
+ + L+ A GM+YL+ ++ IHRDLAARNVLV EN KIADFGL+R + Y
Sbjct: 952 SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008
Query: 542 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 601
K T GRLPV+WMA E+L VYT +SDVWSFGVL+WEI +LGG+PY G+ EL++ L +
Sbjct: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068
Query: 602 GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLS 656
G+RM++P NC +E+Y +MR CW P +RP F Q+ L R+ L + Y+++S
Sbjct: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMS 1121
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 244 bits (623), Expect = 2e-64
Identities = 128/275 (46%), Positives = 182/275 (66%), Gaps = 8/275 (2%)
Query: 370 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 429
+GEG FGQV+ A I KD + + A+K +K+ A++ D D E+E++ +G H N
Sbjct: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
Query: 430 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 489
IINLLGAC G LY+ +EYA GNL ++LR R + ++ I ++ + L+
Sbjct: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
Query: 490 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 549
+ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R + Y K T GRLP
Sbjct: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
Query: 550 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 609
V+WMA E+L VYT SDVWS+GVL+WEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
Query: 610 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 644
NC +E+Y +MR CW P +RP+F Q++ L+R+L
Sbjct: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,947,705
Number of Sequences: 37866
Number of extensions: 1362030
Number of successful extensions: 9279
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 702
Number of HSP's successfully gapped in prelim test: 372
Number of HSP's that attempted gapping in prelim test: 3848
Number of HSP's gapped (non-prelim): 2928
length of query: 704
length of database: 18,247,518
effective HSP length: 109
effective length of query: 595
effective length of database: 14,120,124
effective search space: 8401473780
effective search space used: 8401473780
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.