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Search of human proteins with 222144239
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
(705 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 1452 0.0
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 1305 0.0
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 955 0.0
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 879 0.0
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 876 0.0
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 815 0.0
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 813 0.0
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 755 0.0
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 753 0.0
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 752 0.0
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 709 0.0
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 709 0.0
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 702 0.0
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 702 0.0
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 699 0.0
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 647 0.0
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 640 0.0
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 603 e-172
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 548 e-156
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 548 e-156
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 329 5e-90
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 329 5e-90
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 318 1e-86
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 311 1e-84
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur... 298 1e-80
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur... 297 2e-80
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 289 7e-78
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 289 7e-78
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 244 2e-64
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 244 2e-64
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 1452 bits (3758), Expect = 0.0
Identities = 705/705 (100%), Positives = 705/705 (100%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
Sbjct: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
Query: 301 YGPDGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEF 360
YGPDGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEF
Sbjct: 301 YGPDGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEF 360
Query: 361 PRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEME 420
PRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEME
Sbjct: 361 PRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEME 420
Query: 421 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEE 480
MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEE
Sbjct: 421 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEE 480
Query: 481 QMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDY 540
QMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDY
Sbjct: 481 QMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDY 540
Query: 541 YKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL 600
YKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL
Sbjct: 541 YKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL 600
Query: 601 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPL 660
KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPL
Sbjct: 601 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPL 660
Query: 661 EQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 705
EQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
Sbjct: 661 EQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 705
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 1305 bits (3377), Expect = 0.0
Identities = 649/714 (90%), Positives = 658/714 (92%), Gaps = 14/714 (1%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS---------DAQPHIQWI 291
NHTYHLDVV + I + + G C V + +P
Sbjct: 241 NHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQ 300
Query: 292 KHVEKNGSKYGPDGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYE 351
V K + +P + + VSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYE
Sbjct: 301 PAVHKLTKR-----IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYE 355
Query: 352 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 411
LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD
Sbjct: 356 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 415
Query: 412 LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS 471
LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS
Sbjct: 416 LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS 475
Query: 472 YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL 531
YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL
Sbjct: 476 YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL 535
Query: 532 ARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI 591
ARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI
Sbjct: 536 ARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI 595
Query: 592 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 651
PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE
Sbjct: 596 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 655
Query: 652 EYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 705
EYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
Sbjct: 656 EYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 709
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 955 bits (2469), Expect = 0.0
Identities = 472/649 (72%), Positives = 538/649 (82%), Gaps = 10/649 (1%)
Query: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Query: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
Query: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
Query: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTP 342
DAQPHIQW+KHVE NGSK GPDG PY+ VLKVS ES++SM+SNTPLVRI RLSS + P
Sbjct: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIA-RLSS-GEGP 337
Query: 343 MLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKM 402
LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAVKM
Sbjct: 338 TLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKM 397
Query: 403 LKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRA 462
LKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+LRA
Sbjct: 398 LKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRA 457
Query: 463 RRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN 522
RRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE+N
Sbjct: 458 RRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDN 517
Query: 523 VMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 582
VMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEIFT
Sbjct: 518 VMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFT 577
Query: 583 LGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 642
LGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPTFKQLVEDLD
Sbjct: 578 LGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLD 637
Query: 643 RILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 691
R+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 638 RVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 686
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 879 bits (2270), Expect = 0.0
Identities = 479/742 (64%), Positives = 528/742 (71%), Gaps = 73/742 (9%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE P T + + ++ ++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
Query: 59 EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108
+ RC + W K+G +R IG Y L ++ P D G Y C
Sbjct: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117
Query: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168
S + ++V + R+P+ + +
Sbjct: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152
Query: 169 VPAANTVKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI 217
V+F C + P ++W+K NG ++ + + G ++ ++
Sbjct: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
Query: 218 -MESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQA------------GLPA 264
+ +V D G YTC+ N G H+ L V+ + A G+
Sbjct: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFL 272
Query: 265 NASTVVGGDVEFVCKVYSDAQ-PHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESSSSMN 323
A VV +C++ + + P V K + +P + + VSAESSSSMN
Sbjct: 273 IACMVV---TVILCRMKNTTKKPDFSSQPAVHKLTKR-----IPLRRQVTVSAESSSSMN 324
Query: 324 SNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAE 383
SNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAE
Sbjct: 325 SNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAE 384
Query: 384 AVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGP 443
AVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGP
Sbjct: 385 AVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGP 444
Query: 444 LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS 503
LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS
Sbjct: 445 LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS 504
Query: 504 QKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRV 563
QKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRV
Sbjct: 505 QKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRV 564
Query: 564 YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDC 623
YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDC
Sbjct: 565 YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDC 624
Query: 624 WHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFS 683
WHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFS
Sbjct: 625 WHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFS 684
Query: 684 PDPMPYEPCLPQYPHINGSVKT 705
PDPMPYEPCLPQYPHINGSVKT
Sbjct: 685 PDPMPYEPCLPQYPHINGSVKT 706
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 876 bits (2263), Expect = 0.0
Identities = 482/739 (65%), Positives = 526/739 (71%), Gaps = 69/739 (9%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE P T + + ++ ++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
Query: 59 EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108
+ RC + W K+G +R IG Y L ++ P D G Y C
Sbjct: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117
Query: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168
S + ++V + R+P+ + +
Sbjct: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152
Query: 169 VPAANTVKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI 217
V+F C + P ++W+K NG ++ + + G ++ ++
Sbjct: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
Query: 218 -MESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEF 276
+ +V D G YTC+ N G H+ L V+ +P R P + +
Sbjct: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP-APGREKEITASPDYLEIAI-----Y 266
Query: 277 VCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK----------VSAESSSSMNSNT 326
V+ A + I KN +K PD V K VSAESSSSMNSNT
Sbjct: 267 CIGVFLIACMVVTVILCRMKNTTKK-PDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNT 325
Query: 327 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 386
PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG
Sbjct: 326 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 385
Query: 387 IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV 446
IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV
Sbjct: 386 IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV 445
Query: 447 IVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKC 506
IVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKC
Sbjct: 446 IVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKC 505
Query: 507 IHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTH 566
IHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTH
Sbjct: 506 IHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTH 565
Query: 567 QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHA 626
QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHA
Sbjct: 566 QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHA 625
Query: 627 VPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDP 686
VPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDP
Sbjct: 626 VPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDP 685
Query: 687 MPYEPCLPQYPHINGSVKT 705
MPYEPCLPQYPHINGSVKT
Sbjct: 686 MPYEPCLPQYPHINGSVKT 704
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 815 bits (2104), Expect = 0.0
Identities = 426/555 (76%), Positives = 453/555 (81%), Gaps = 30/555 (5%)
Query: 175 VKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLIMESVVP 223
V+F C + P ++W+K NG ++ + + G N L + +V
Sbjct: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTE 332
Query: 224 SDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVC-KVYS 282
+D G Y C V N G N + L V+ + P + + A+ + ++ C V+
Sbjct: 333 ADAGEYICKVSNYIGQANQSAWLTVLPKQ-QAPGREKEITASPDYL---EIAIYCIGVFL 388
Query: 283 DAQPHIQWIKHVEKNGSKYGPD------------GLPYLKVLKVSAESSSSMNSNTPLVR 330
A + I KN +K PD +P + + VSAESSSSMNSNTPLVR
Sbjct: 389 IACMVVTVILCRMKNTTKK-PDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 447
Query: 331 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 390
ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD
Sbjct: 448 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 507
Query: 391 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 450
KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY
Sbjct: 508 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 567
Query: 451 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 510
ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD
Sbjct: 568 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 627
Query: 511 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 570
LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV
Sbjct: 628 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 687
Query: 571 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 630
WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ
Sbjct: 688 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 747
Query: 631 RPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYE 690
RPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYE
Sbjct: 748 RPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYE 807
Query: 691 PCLPQYPHINGSVKT 705
PCLPQYPHINGSVKT
Sbjct: 808 PCLPQYPHINGSVKT 822
Score = 654 bits (1688), Expect = 0.0
Identities = 316/321 (98%), Positives = 318/321 (99%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
Sbjct: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
Query: 301 YGPDGLPYLKVLKVSAESSSS 321
YGPDGLPYLKVLK S +SS+
Sbjct: 301 YGPDGLPYLKVLKHSGINSSN 321
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 813 bits (2100), Expect = 0.0
Identities = 422/556 (75%), Positives = 451/556 (81%), Gaps = 33/556 (5%)
Query: 175 VKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI-MESVV 222
V+F C + P ++W+K NG ++ + + G ++ ++ + +V
Sbjct: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 333
Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQA------------GLPANASTVV 270
D G YTC+ N G H+ L V+ + A G+ A VV
Sbjct: 334 FEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVV 393
Query: 271 GGDVEFVCKVYSDAQ-PHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESSSSMNSNTPLV 329
+C++ + + P V K + +P + + VSAESSSSMNSNTPLV
Sbjct: 394 ---TVILCRMKNTTKKPDFSSQPAVHKLTKR-----IPLRRQVTVSAESSSSMNSNTPLV 445
Query: 330 RITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDK 389
RITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDK
Sbjct: 446 RITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDK 505
Query: 390 DKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 449
DKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE
Sbjct: 506 DKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 565
Query: 450 YASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHR 509
YASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHR
Sbjct: 566 YASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHR 625
Query: 510 DLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSD 569
DLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSD
Sbjct: 626 DLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSD 685
Query: 570 VWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPS 629
VWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPS
Sbjct: 686 VWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPS 745
Query: 630 QRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPY 689
QRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPY
Sbjct: 746 QRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPY 805
Query: 690 EPCLPQYPHINGSVKT 705
EPCLPQYPHINGSVKT
Sbjct: 806 EPCLPQYPHINGSVKT 821
Score = 654 bits (1686), Expect = 0.0
Identities = 319/348 (91%), Positives = 325/348 (93%), Gaps = 1/348 (0%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
Sbjct: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
Query: 301 YGPDGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVS 348
YGPDGLPYLKVLK + +++ +R T + LAG S
Sbjct: 301 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT-FEDAGEYTCLAGNS 347
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 755 bits (1949), Expect = 0.0
Identities = 428/737 (58%), Positives = 483/737 (65%), Gaps = 99/737 (13%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 40 -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
T + + ++ +++ RC + W K+G +R IG
Sbjct: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117
Query: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Y L ++ P D G Y C S + ++V +
Sbjct: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161
Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
R+P+ + + V+F C + P ++W+K NG ++
Sbjct: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212
Query: 199 KQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVVE 250
+ + G ++ ++ + +V D G YTC+ N G H+ L V+
Sbjct: 213 GPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP 272
Query: 251 RSPHRPILQA------------GLPANASTVVGGDVEFVCKVYSDAQ-PHIQWIKHVEKN 297
+ A G+ A VV +C++ + + P V K
Sbjct: 273 APGREKEITASPDYLEIAIYCIGVFLIACMVV---TVILCRMKNTTKKPDFSSQPAVHKL 329
Query: 298 GSKYGPDGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK 357
+ +P + + VSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK
Sbjct: 330 TKR-----IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK 384
Query: 358 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 417
WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS
Sbjct: 385 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 444
Query: 418 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRV 477
EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRV
Sbjct: 445 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRV 504
Query: 478 PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN 537
PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN
Sbjct: 505 PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN 564
Query: 538 IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 597
IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF
Sbjct: 565 IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 624
Query: 598 KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLS 657
KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE +S
Sbjct: 625 KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEEKKVS 684
Query: 658 QPLEQYSPSYPDTRSSC 674
++ + P + C
Sbjct: 685 GAVDCHKPPCNPSHLPC 701
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 753 bits (1944), Expect = 0.0
Identities = 407/740 (55%), Positives = 500/740 (67%), Gaps = 87/740 (11%)
Query: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
Query: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
Query: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
Query: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ 259
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQ
Sbjct: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ 252
Query: 260 AGLPANASTVVGGDVEFVCKVYSDAQ---------------------PHIQWIKHVEKNG 298
AGLPAN + VVG DVE +CKVYSDAQ P++Q +K + N
Sbjct: 253 AGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINS 312
Query: 299 SKY-------------------------------------GPDGLPYLK----------- 310
S+ G +P+L
Sbjct: 313 SEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHLTCDSLTPAGRTK 372
Query: 311 --VLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLG 368
L+ S ES SS S++ LVR RLSS+ +LAG+ +LP DP WEFPRD+L LG
Sbjct: 373 SPTLQFSLESGSSGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLG 430
Query: 369 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 428
KPLGEGCFGQVV AEA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+H
Sbjct: 431 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRH 490
Query: 429 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 488
KNIINLLG CTQ+GPLYVIVE A+KGNLRE+LRARRPPG + S D R E ++F LV
Sbjct: 491 KNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLV 550
Query: 489 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 548
SC YQ+ARGM+YL S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGR
Sbjct: 551 SCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGR 610
Query: 549 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 608
LPVKWMAPEALFDRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+
Sbjct: 611 LPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDR 670
Query: 609 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYP 668
P +C ELY +MR+CWHA PSQRPTFKQLVE LD++L L +EEYLDL YSPS
Sbjct: 671 PPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGG 729
Query: 669 DTRSSCSSGDDSVFSPDPMP 688
D S+CSS DSVFS DP+P
Sbjct: 730 DASSTCSS-SDSVFSHDPLP 748
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 752 bits (1941), Expect = 0.0
Identities = 428/713 (60%), Positives = 476/713 (66%), Gaps = 96/713 (13%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 40 -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
T + + ++ +++ RC + W K+G +R IG
Sbjct: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117
Query: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Y L ++ P D G Y C S + ++V +
Sbjct: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161
Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
R+P+ + + V+F C + P ++W+K NG ++
Sbjct: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212
Query: 199 KQEH-------RIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVER 251
+ + G N L + +V +D G Y C V N G N + L V+ +
Sbjct: 213 GPDGLPYLKVLKHSGINSSNAE-VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK 271
Query: 252 SPHRPILQAGLPANASTVVGGDVEFVC-KVYSDAQPHIQWIKHVEKNGSKYGPD------ 304
P + + A+ + ++ C V+ A + I KN +K PD
Sbjct: 272 Q-QAPGREKEITASPDYL---EIAIYCIGVFLIACMVVTVILCRMKNTTKK-PDFSSQPA 326
Query: 305 ------GLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKW 358
+P + + VSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKW
Sbjct: 327 VHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKW 386
Query: 359 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 418
EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE
Sbjct: 387 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 446
Query: 419 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVP 478
MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVP
Sbjct: 447 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVP 506
Query: 479 EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI 538
EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI
Sbjct: 507 EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI 566
Query: 539 DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK 598
DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK
Sbjct: 567 DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK 626
Query: 599 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 651
LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE
Sbjct: 627 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 679
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 709 bits (1830), Expect = 0.0
Identities = 401/767 (52%), Positives = 491/767 (64%), Gaps = 101/767 (13%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEE---------------------PP 39
M SW + V+ ATL ARPS +L E L E P
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
Query: 40 TKYQIS----QPEVYVAAPGESLEVRCLLKDAA--VISWTKDGVHLGPNNRTVLIGEYLQ 93
Y S + +++ ++++ +C + W K+G P++R IG Y +
Sbjct: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR---IGGY-K 116
Query: 94 IKGAT---------PRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFV 144
++ AT P D G Y C S + ++V +
Sbjct: 117 VRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVE------------------ 158
Query: 145 SENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEFKQ 200
R+P+ + V + V+F C +P P ++WLK NG +
Sbjct: 159 -------RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 211
Query: 201 EH-------RIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVVERS 252
++ + G ++ ++ + +V D G YTC+ N G +H+ L V+E
Sbjct: 212 DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEAL 271
Query: 253 PHRP-ILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGP-------- 303
RP ++ + L G C V S I + K+G+K
Sbjct: 272 EERPAVMTSPLYLEIIIYCTGAFLISCMVGSV-------IVYKMKSGTKKSDFHSQMAVH 324
Query: 304 ---DGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEF 360
+P + + VSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+WE
Sbjct: 325 KLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWEL 382
Query: 361 PRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEME 420
PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SEME
Sbjct: 383 PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEME 442
Query: 421 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEE 480
MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + PEE
Sbjct: 443 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEE 502
Query: 481 QMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDY 540
Q++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDY
Sbjct: 503 QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDY 562
Query: 541 YKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL 600
YKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLL
Sbjct: 563 YKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL 622
Query: 601 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPL 660
KEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL
Sbjct: 623 KEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPL 682
Query: 661 EQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 704
+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P NG +K
Sbjct: 683 DQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 729
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 709 bits (1829), Expect = 0.0
Identities = 401/769 (52%), Positives = 491/769 (63%), Gaps = 103/769 (13%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTL----------------------EPEEP 38
M SW + V+ ATL ARPS +L E L +P
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
Query: 39 PTKYQISQPE-----VYVAAPGESLEVRCLLKDAA--VISWTKDGVHLGPNNRTVLIGEY 91
P + PE ++ ++++ +C + W K+G P++R IG Y
Sbjct: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR---IGGY 117
Query: 92 LQIKGAT---------PRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
+++ AT P D G Y C S + ++V +
Sbjct: 118 -KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVE---------------- 160
Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
R+P+ + V + V+F C +P P ++WLK NG +
Sbjct: 161 ---------RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 211
Query: 199 KQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVVE 250
++ + G ++ ++ + +V D G YTC+ N G +H+ L V+E
Sbjct: 212 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 271
Query: 251 RSPHRP-ILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGP------ 303
RP ++ + L G C V S I + K+G+K
Sbjct: 272 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSV-------IVYKMKSGTKKSDFHSQMA 324
Query: 304 -----DGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKW 358
+P + + VSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+W
Sbjct: 325 VHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRW 382
Query: 359 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 418
E PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SE
Sbjct: 383 ELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISE 442
Query: 419 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVP 478
MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + P
Sbjct: 443 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNP 502
Query: 479 EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI 538
EEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++I
Sbjct: 503 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHI 562
Query: 539 DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK 598
DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFK
Sbjct: 563 DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFK 622
Query: 599 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQ 658
LLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+EYLDLS
Sbjct: 623 LLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSM 682
Query: 659 PLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 704
PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P NG +K
Sbjct: 683 PLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 731
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 702 bits (1813), Expect = 0.0
Identities = 382/671 (56%), Positives = 460/671 (68%), Gaps = 74/671 (11%)
Query: 70 ISWTKDGVHLGPNNRTVLIGEYLQIKGAT---------PRDSGLYACTASRTVDSETWYF 120
+ W K+G P++R IG Y +++ AT P D G Y C S +
Sbjct: 186 LRWLKNGKEFKPDHR---IGGY-KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTY 241
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
++V + R+P+ + V + V+F C
Sbjct: 242 QLDVVE-------------------------RSPHRPILQAGLPANKTVALGSNVEFMCK 276
Query: 181 AGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGN 228
+P P ++WLK NG + ++ + G ++ ++ + +V D G
Sbjct: 277 VYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGE 336
Query: 229 YTCVVENEYGSINHTYHLDVVERSPHRP-ILQAGLPANASTVVGGDVEFVCKVYSDAQPH 287
YTC+ N G +H+ L V+E RP ++ + L G C V S
Sbjct: 337 YTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSV---- 392
Query: 288 IQWIKHVEKNGSKYGP-----------DGLPYLKVLKVSAESSSSMNSNTPLVRITTRLS 336
I + K+G+K +P + + VSA+SS+SMNS LVR +RLS
Sbjct: 393 ---IVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLS 448
Query: 337 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 396
S+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP
Sbjct: 449 SSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 507
Query: 397 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 456
VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 508 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 567
Query: 457 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 516
REYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNV
Sbjct: 568 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 627
Query: 517 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 576
LVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL
Sbjct: 628 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 687
Query: 577 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 636
+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQ
Sbjct: 688 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 747
Query: 637 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQ 695
LVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP+
Sbjct: 748 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 807
Query: 696 YPH--INGSVK 704
+P NG +K
Sbjct: 808 HPAQLANGGLK 818
Score = 379 bits (973), Expect = e-105
Identities = 185/324 (57%), Positives = 233/324 (71%), Gaps = 11/324 (3%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
Query: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
Query: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVK 176
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVK
Sbjct: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVK 173
Query: 177 FRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
F+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENE
Sbjct: 174 FKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE 233
Query: 237 YGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEK 296
YGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E
Sbjct: 234 YGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV 293
Query: 297 NGSKYGPDGLPYLKVLKVSAESSS 320
NGSK GPD LPY+++LK + +++
Sbjct: 294 NGSKIGPDNLPYVQILKTAGVNTT 317
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 702 bits (1813), Expect = 0.0
Identities = 382/671 (56%), Positives = 460/671 (68%), Gaps = 74/671 (11%)
Query: 70 ISWTKDGVHLGPNNRTVLIGEYLQIKGAT---------PRDSGLYACTASRTVDSETWYF 120
+ W K+G P++R IG Y +++ AT P D G Y C S +
Sbjct: 188 LRWLKNGKEFKPDHR---IGGY-KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTY 243
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
++V + R+P+ + V + V+F C
Sbjct: 244 QLDVVE-------------------------RSPHRPILQAGLPANKTVALGSNVEFMCK 278
Query: 181 AGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGN 228
+P P ++WLK NG + ++ + G ++ ++ + +V D G
Sbjct: 279 VYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGE 338
Query: 229 YTCVVENEYGSINHTYHLDVVERSPHRP-ILQAGLPANASTVVGGDVEFVCKVYSDAQPH 287
YTC+ N G +H+ L V+E RP ++ + L G C V S
Sbjct: 339 YTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSV---- 394
Query: 288 IQWIKHVEKNGSKYGP-----------DGLPYLKVLKVSAESSSSMNSNTPLVRITTRLS 336
I + K+G+K +P + + VSA+SS+SMNS LVR +RLS
Sbjct: 395 ---IVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLS 450
Query: 337 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 396
S+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP
Sbjct: 451 SSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 509
Query: 397 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 456
VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 510 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 569
Query: 457 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 516
REYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNV
Sbjct: 570 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 629
Query: 517 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 576
LVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL
Sbjct: 630 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 689
Query: 577 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 636
+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQ
Sbjct: 690 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 749
Query: 637 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQ 695
LVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP+
Sbjct: 750 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 809
Query: 696 YPH--INGSVK 704
+P NG +K
Sbjct: 810 HPAQLANGGLK 820
Score = 378 bits (971), Expect = e-105
Identities = 185/326 (56%), Positives = 233/326 (71%), Gaps = 13/326 (3%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
Query: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
Query: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANT 174
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA T
Sbjct: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKT 173
Query: 175 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 234
VKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VE
Sbjct: 174 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 233
Query: 235 NEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHV 294
NEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+
Sbjct: 234 NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 293
Query: 295 EKNGSKYGPDGLPYLKVLKVSAESSS 320
E NGSK GPD LPY+++LK + +++
Sbjct: 294 EVNGSKIGPDNLPYVQILKTAGVNTT 319
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 699 bits (1803), Expect = 0.0
Identities = 372/501 (74%), Positives = 399/501 (79%), Gaps = 30/501 (5%)
Query: 175 VKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLIMESVVP 223
V+F C + P ++W+K NG ++ + + G N L + +V
Sbjct: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTE 332
Query: 224 SDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVC-KVYS 282
+D G Y C V N G N + L V+ + P + + A+ + ++ C V+
Sbjct: 333 ADAGEYICKVSNYIGQANQSAWLTVLPKQ-QAPGREKEITASPDYL---EIAIYCIGVFL 388
Query: 283 DAQPHIQWIKHVEKNGSKYGPD------------GLPYLKVLKVSAESSSSMNSNTPLVR 330
A + I KN +K PD +P + + VSAESSSSMNSNTPLVR
Sbjct: 389 IACMVVTVILCRMKNTTKK-PDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 447
Query: 331 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 390
ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD
Sbjct: 448 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 507
Query: 391 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 450
KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY
Sbjct: 508 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 567
Query: 451 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 510
ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD
Sbjct: 568 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 627
Query: 511 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 570
LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV
Sbjct: 628 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 687
Query: 571 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 630
WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ
Sbjct: 688 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 747
Query: 631 RPTFKQLVEDLDRILTLTTNE 651
RPTFKQLVEDLDRILTLTTNE
Sbjct: 748 RPTFKQLVEDLDRILTLTTNE 768
Score = 654 bits (1688), Expect = 0.0
Identities = 316/321 (98%), Positives = 318/321 (99%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
Sbjct: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
Query: 301 YGPDGLPYLKVLKVSAESSSS 321
YGPDGLPYLKVLK S +SS+
Sbjct: 301 YGPDGLPYLKVLKHSGINSSN 321
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 647 bits (1668), Expect = 0.0
Identities = 339/537 (63%), Positives = 403/537 (75%), Gaps = 29/537 (5%)
Query: 175 VKFRCPAGGNPMPTMRWLKN-----------GKEFKQEHRIGGYKVRNQHWSLI-MESVV 222
V+F C + P ++WLK+ G + + G ++ ++ + +V
Sbjct: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVT 330
Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANA-STVVGGDVEFVCKVY 281
D G YTC+ N G +H+ L V+ +++A + + ++ V F +
Sbjct: 331 FEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEE--LVEADEAGSVYAGILSYGVGFFLFIL 388
Query: 282 SDAQPHIQWIKHVEKNGSKYGPDGLPYLKVL-------KVSAESSSSMNSNTPLVRITTR 334
A + ++ K G G P + + +VS ES++SM+SNTPLVRI R
Sbjct: 389 VVAAVTLCRLRSPPKKGL-----GSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIA-R 442
Query: 335 LSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKE 394
LSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+ +
Sbjct: 443 LSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAK 501
Query: 395 AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 454
VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KG
Sbjct: 502 PVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKG 561
Query: 455 NLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAAR 514
NLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAAR
Sbjct: 562 NLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAAR 621
Query: 515 NVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 574
NVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG
Sbjct: 622 NVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 681
Query: 575 VLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF 634
VL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPTF
Sbjct: 682 VLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTF 741
Query: 635 KQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 691
KQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 742 KQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 798
Score = 323 bits (829), Expect = 3e-88
Identities = 161/278 (57%), Positives = 198/278 (71%), Gaps = 8/278 (2%)
Query: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Query: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
Query: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
Query: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESSS 320
DAQPHIQW+KHVE NGSK GPDG PY+ VLK + +++
Sbjct: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTT 317
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 640 bits (1650), Expect = 0.0
Identities = 341/539 (63%), Positives = 399/539 (74%), Gaps = 31/539 (5%)
Query: 175 VKFRCPAGGNPMPTMRWLK----NGKEFKQEHRIGGYKVRNQHW---------SLIMESV 221
V+F C + P ++WLK NG + + Y + W L + +V
Sbjct: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT--PYVTVLKSWISESVEADVRLRLANV 328
Query: 222 VPSDKGNYTCVVENEYGSINHTYHLDVV-ERSPHRPILQAGLPANA-STVVGGDVEFVCK 279
D G Y C N G + L V R+ +++A + + ++ V F
Sbjct: 329 SERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLF 388
Query: 280 VYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVL-------KVSAESSSSMNSNTPLVRIT 332
+ A + ++ K G G P + + +VS ES++SM+SNTPLVRI
Sbjct: 389 ILVVAAVTLCRLRSPPKKGL-----GSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIA 443
Query: 333 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 392
RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+
Sbjct: 444 -RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRA 501
Query: 393 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 452
+ VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+
Sbjct: 502 AKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAA 561
Query: 453 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 512
KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLA
Sbjct: 562 KGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 621
Query: 513 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 572
ARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS
Sbjct: 622 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 681
Query: 573 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 632
FGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRP
Sbjct: 682 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP 741
Query: 633 TFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 691
TFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 742 TFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 800
Score = 323 bits (829), Expect = 3e-88
Identities = 164/292 (56%), Positives = 200/292 (68%), Gaps = 8/292 (2%)
Query: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Query: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
Query: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
Query: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESSSSMNSNTPLVRITTR 334
DAQPHIQW+KHVE NGSK GPDG PY+ VLK S + L ++ R
Sbjct: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSER 331
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 603 bits (1556), Expect = e-172
Identities = 346/671 (51%), Positives = 423/671 (63%), Gaps = 111/671 (16%)
Query: 70 ISWTKDGVHLGPNNRTVLIGEYLQIKGAT---------PRDSGLYACTASRTVDSETWYF 120
+ W K+G P++R IG Y +++ AT P D G Y C S +
Sbjct: 188 LRWLKNGKEFKPDHR---IGGY-KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTY 243
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
++V + R+P+ + V + V+F C
Sbjct: 244 QLDVVE-------------------------RSPHRPILQAGLPANKTVALGSNVEFMCK 278
Query: 181 AGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGN 228
+P P ++WLK NG + ++ + G ++ ++ + +V D G
Sbjct: 279 VYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGE 338
Query: 229 YTCVVENEYGSINHTYHLDVVERSPHRP-ILQAGLPANASTVVGGDVEFVCKVYSDAQPH 287
YTC+ N G +H+ L V+E RP ++ + L G C V S
Sbjct: 339 YTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSV---- 394
Query: 288 IQWIKHVEKNGSKYGP-----------DGLPYLKVLKVSAESSSSMNSNTPLVRITTRLS 336
I + K+G+K +P + + VSA+SS+SMNS LVR +RLS
Sbjct: 395 ---IVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLS 450
Query: 337 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 396
S+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP
Sbjct: 451 SSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 509
Query: 397 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 456
VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 510 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 569
Query: 457 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 516
REYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNV
Sbjct: 570 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 629
Query: 517 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 576
LVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL
Sbjct: 630 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 689
Query: 577 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 636
+WEIFTLGGSPYPG+PVEEL FKQ
Sbjct: 690 LWEIFTLGGSPYPGVPVEEL-------------------------------------FKQ 712
Query: 637 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQ 695
LVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP+
Sbjct: 713 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 772
Query: 696 YPH--INGSVK 704
+P NG +K
Sbjct: 773 HPAQLANGGLK 783
Score = 378 bits (971), Expect = e-105
Identities = 185/326 (56%), Positives = 233/326 (71%), Gaps = 13/326 (3%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
Query: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
Query: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANT 174
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA T
Sbjct: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKT 173
Query: 175 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 234
VKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VE
Sbjct: 174 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 233
Query: 235 NEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHV 294
NEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+
Sbjct: 234 NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 293
Query: 295 EKNGSKYGPDGLPYLKVLKVSAESSS 320
E NGSK GPD LPY+++LK + +++
Sbjct: 294 EVNGSKIGPDNLPYVQILKTAGVNTT 319
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 548 bits (1411), Expect = e-156
Identities = 327/685 (47%), Positives = 413/685 (60%), Gaps = 70/685 (10%)
Query: 35 PEEPP--TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
P++ P T Q + +++ G +++ RC I W KDG NR IG
Sbjct: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENR---IGG 199
Query: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
L ++ P D G Y C V S + ++++V +
Sbjct: 200 IRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLE---------------- 243
Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
R+P+ + + V+ C + P ++WLK NG F
Sbjct: 244 ---------RSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSF 294
Query: 199 KQEH--RIGGYKVRNQHWS----LIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERS 252
+ + K + + S L + +V D G YTC+ N G + L V+
Sbjct: 295 GADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEE 354
Query: 253 PHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVL 312
P A P T + + S A + + + + + +G P V
Sbjct: 355 D--PTWTAAAPEARYTDI-----ILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQ 407
Query: 313 KVSA---------ESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 363
K+S ES SS S++ LVR RLSS+ +LAG+ +LP DP WEFPRD
Sbjct: 408 KLSRFPLARQFSLESGSSGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRD 465
Query: 364 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 423
+L LGKPLGEGCFGQVV AEA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK
Sbjct: 466 RLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMK 525
Query: 424 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 483
+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+LRARRPPG + S D R E ++
Sbjct: 526 LIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLS 585
Query: 484 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 543
F LVSC YQ+ARGM+YL S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKK
Sbjct: 586 FPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKK 645
Query: 544 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 603
T+NGRLPVKWMAPEALFDRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EG
Sbjct: 646 TSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREG 705
Query: 604 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQY 663
HRMD+P +C ELY +MR+CWHA PSQRPTFKQLVE LD++L L +EEYLDL Y
Sbjct: 706 HRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPY 764
Query: 664 SPSYPDTRSSCSSGDDSVFSPDPMP 688
SPS D S+CSS DSVFS DP+P
Sbjct: 765 SPSGGDASSTCSS-SDSVFSHDPLP 788
Score = 291 bits (746), Expect = 1e-78
Identities = 150/303 (49%), Positives = 200/303 (66%), Gaps = 12/303 (3%)
Query: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
Query: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
Query: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
Query: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ 259
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQ
Sbjct: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ 252
Query: 260 AGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESS 319
AGLPAN + VVG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK + +S
Sbjct: 253 AGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINS 312
Query: 320 SSM 322
S +
Sbjct: 313 SEV 315
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 548 bits (1411), Expect = e-156
Identities = 327/685 (47%), Positives = 413/685 (60%), Gaps = 70/685 (10%)
Query: 35 PEEPP--TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
P++ P T Q + +++ G +++ RC I W KDG NR IG
Sbjct: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENR---IGG 199
Query: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
L ++ P D G Y C V S + ++++V +
Sbjct: 200 IRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLE---------------- 243
Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
R+P+ + + V+ C + P ++WLK NG F
Sbjct: 244 ---------RSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSF 294
Query: 199 KQEH--RIGGYKVRNQHWS----LIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERS 252
+ + K + + S L + +V D G YTC+ N G + L V+
Sbjct: 295 GADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEE 354
Query: 253 PHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVL 312
P A P T + + S A + + + + + +G P V
Sbjct: 355 D--PTWTAAAPEARYTDI-----ILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQ 407
Query: 313 KVSA---------ESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 363
K+S ES SS S++ LVR RLSS+ +LAG+ +LP DP WEFPRD
Sbjct: 408 KLSRFPLARQFSLESGSSGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRD 465
Query: 364 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 423
+L LGKPLGEGCFGQVV AEA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK
Sbjct: 466 RLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMK 525
Query: 424 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 483
+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNLRE+LRARRPPG + S D R E ++
Sbjct: 526 LIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLS 585
Query: 484 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 543
F LVSC YQ+ARGM+YL S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKK
Sbjct: 586 FPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKK 645
Query: 544 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 603
T+NGRLPVKWMAPEALFDRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EG
Sbjct: 646 TSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREG 705
Query: 604 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQY 663
HRMD+P +C ELY +MR+CWHA PSQRPTFKQLVE LD++L L +EEYLDL Y
Sbjct: 706 HRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPY 764
Query: 664 SPSYPDTRSSCSSGDDSVFSPDPMP 688
SPS D S+CSS DSVFS DP+P
Sbjct: 765 SPSGGDASSTCSS-SDSVFSHDPLP 788
Score = 291 bits (746), Expect = 1e-78
Identities = 150/303 (49%), Positives = 200/303 (66%), Gaps = 12/303 (3%)
Query: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
Query: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
Query: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
Query: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ 259
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQ
Sbjct: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ 252
Query: 260 AGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESS 319
AGLPAN + VVG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK + +S
Sbjct: 253 AGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINS 312
Query: 320 SSM 322
S +
Sbjct: 313 SEV 315
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 329 bits (844), Expect = 5e-90
Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%)
Query: 318 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 370
SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK
Sbjct: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
Query: 371 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 429
LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H
Sbjct: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
Query: 430 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 481
++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E
Sbjct: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
Query: 482 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 541
+T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y
Sbjct: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
Query: 542 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 601
K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
Query: 602 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 661
GHRM++P NC+ E+Y +M CW P +RP F + +DL+++ + +YLDL+
Sbjct: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023
Query: 662 QYSPSYPD 669
S Y D
Sbjct: 1024 SDSLIYDD 1031
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 329 bits (844), Expect = 5e-90
Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%)
Query: 318 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 370
SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK
Sbjct: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
Query: 371 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 429
LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H
Sbjct: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
Query: 430 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 481
++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E
Sbjct: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
Query: 482 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 541
+T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y
Sbjct: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
Query: 542 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 601
K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
Query: 602 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 661
GHRM++P NC+ E+Y +M CW P +RP F + +DL+++ + +YLDL+
Sbjct: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023
Query: 662 QYSPSYPD 669
S Y D
Sbjct: 1024 SDSLIYDD 1031
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 318 bits (814), Expect = 1e-86
Identities = 219/618 (35%), Positives = 306/618 (49%), Gaps = 124/618 (20%)
Query: 92 LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
L I + +DSG YAC A E +T ++
Sbjct: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEIT----------------------IRDQ 658
Query: 152 RAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRN 211
APY H V +++ C A G P P + W KN + +QE G +
Sbjct: 659 EAPYLLRNLSD----HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEP---GIILGP 711
Query: 212 QHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVG 271
+L +E V D+G Y C N+ GS+ + +L V S + L T V
Sbjct: 712 GSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITLTC---TCVA 768
Query: 272 GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESSSSMNSNTPLVRI 331
+ ++ +I+ ++++ S+ D YL ++ E PL
Sbjct: 769 ATLFWLLLTL--------FIRKMKRSSSEIKTD---YLSIIMDPDE--------VPLDEQ 809
Query: 332 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 391
RL A KWEF R++L LGK LG G FG+VV A A GI K
Sbjct: 810 CERLPYDAS----------------KWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSP 853
Query: 392 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEY 450
TVAVKMLK+ AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY
Sbjct: 854 TCR--TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEY 911
Query: 451 ASKGNLREYLRARRP--------------------PGMEYSY------------------ 472
GNL YL+++R PG+E
Sbjct: 912 CKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGF 971
Query: 473 ----DINRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT 519
++ V EE+ +T +DL+S ++Q+ARGME+L+S+KCIHRDLAARN+L++
Sbjct: 972 QEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLS 1031
Query: 520 ENNVMKIADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMW 578
ENNV+KI DFGLARDI N DY +K RLP+KWMAPE++FD++Y+ +SDVWS+GVL+W
Sbjct: 1032 ENNVVKICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVWSYGVLLW 1090
Query: 579 EIFTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQL 637
EIF+LGGSPYPG+ ++E F L+EG RM P T E+Y +M DCWH P +RP F +L
Sbjct: 1091 EIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAEL 1150
Query: 638 VEDLDRILTLTTNEEYLD 655
VE L +L ++ D
Sbjct: 1151 VEKLGDLLQANVQQDGKD 1168
Score = 40.4 bits (93), Expect = 0.006
Identities = 33/141 (23%), Positives = 57/141 (40%), Gaps = 10/141 (7%)
Query: 157 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
T + ++ L V + + P P + WLK+G + Y R +SL
Sbjct: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRG--YSL 390
Query: 217 IMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 272
I++ V D GNYT ++ N + ++ T ++V + + + + P A +G
Sbjct: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
Query: 273 DVEFVCKVYSDAQPHIQWIKH 293
C Y QP I+W H
Sbjct: 449 RQILTCTAYGIPQPTIKWFWH 469
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 311 bits (797), Expect = 1e-84
Identities = 181/389 (46%), Positives = 233/389 (59%), Gaps = 63/389 (16%)
Query: 352 LPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 410
LP D KWEFPRD+L LGKPLG G FGQV+ A+A GIDK TVAVKMLK+ AT
Sbjct: 820 LPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCR--TVAVKMLKEGATHS 877
Query: 411 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEYASKGNLREYLRARRPPGME 469
+ L+SE++++ IG H N++NLLGACT+ G PL VIVE+ GNL YLR++R +
Sbjct: 878 EHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVP 937
Query: 470 YS-----------------YDINR------------------------VPEEQ------- 481
Y D+ R V EE+
Sbjct: 938 YKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYK 997
Query: 482 --MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 539
+T + L+ ++Q+A+GME+LAS+KCIHRDLAARN+L++E NV+KI DFGLARDI
Sbjct: 998 DFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDP 1057
Query: 540 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF-K 598
Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVL+WEIF+LG SPYPG+ ++E F +
Sbjct: 1058 DYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCR 1117
Query: 599 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE-----Y 653
LKEG RM P T E+Y M DCWH PSQRPTF +LVE L +L ++
Sbjct: 1118 RLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIV 1177
Query: 654 LDLSQPL---EQYSPSYPDTRSSCSSGDD 679
L +S+ L E S P + SC ++
Sbjct: 1178 LPISETLSMEEDSGLSLPTSPVSCMEEEE 1206
Score = 45.4 bits (106), Expect = 2e-04
Identities = 54/208 (25%), Positives = 79/208 (37%), Gaps = 38/208 (18%)
Query: 92 LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
L I G T D GLY C AS + ++ V V + + FV+ S
Sbjct: 292 LTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHE--------------KPFVAFGSG-- 335
Query: 152 RAPYWTNTEKMEKRLHAVPAANTVKFRCPAG--GNPMPTMRWLKNGKEFKQEHRIGGYKV 209
ME + A + R PA G P P ++W KNG + H I
Sbjct: 336 ----------MESLVEATVGE---RVRIPAKYLGYPPPEIKWYKNGIPLESNHTI----- 377
Query: 210 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 269
+ H IME V D GNYT ++ N ++ + +V P + ++ + S
Sbjct: 378 KAGHVLTIME-VSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQ 436
Query: 270 VGGDVEFVCKVYSDAQP-HIQWIKHVEK 296
G C VY+ P HI W +E+
Sbjct: 437 YGTTQTLTCTVYAIPPPHHIHWYWQLEE 464
Score = 33.5 bits (75), Expect = 0.69
Identities = 26/84 (30%), Positives = 37/84 (44%), Gaps = 7/84 (8%)
Query: 216 LIMESVVPS--DKGNYTCVVENEYGSINHTY--HLDVVERSPHRPILQAGLPANASTVVG 271
LIME S D+G+Y C+ ++ H L V+ER P + L N +T +G
Sbjct: 625 LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIG 681
Query: 272 GDVEFVCKVYSDAQPHIQWIKHVE 295
+E C + P I W K E
Sbjct: 682 ESIEVSCTASGNPPPQIMWFKDNE 705
Score = 30.0 bits (66), Expect = 7.7
Identities = 16/55 (29%), Positives = 27/55 (49%), Gaps = 1/55 (1%)
Query: 70 ISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNV 124
I W K+G+ L +N T+ G L I + RD+G Y + + E +V++
Sbjct: 362 IKWYKNGIPL-ESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSL 415
>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
[Homo sapiens]
Length = 300
Score = 298 bits (763), Expect = 1e-80
Identities = 136/192 (70%), Positives = 158/192 (82%), Gaps = 3/192 (1%)
Query: 126 DAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVKF+CP+
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 90
Query: 183 GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH 242
G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSINH
Sbjct: 91 GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 150
Query: 243 TYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYG 302
TY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E NGSK G
Sbjct: 151 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 210
Query: 303 PDGLPYLKVLKV 314
PD LPY+++LKV
Sbjct: 211 PDNLPYVQILKV 222
Score = 35.4 bits (80), Expect = 0.18
Identities = 45/229 (19%), Positives = 76/229 (33%), Gaps = 63/229 (27%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEE---------------------PP 39
M SW + V+ ATL ARPS +L E L E P
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
Query: 40 TKYQIS----QPEVYVAAPGESLEVRCLLKDA--AVISWTKDGVHLGPNNRTVLIGEY-- 91
Y S + +++ ++++ +C + W K+G P++R IG Y
Sbjct: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR---IGGYKV 117
Query: 92 ------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVS 145
+ + P D G Y C S + ++V +
Sbjct: 118 RYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVE------------------- 158
Query: 146 ENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKN 194
R+P+ + V + V+F C +P P ++WLK+
Sbjct: 159 ------RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKH 201
>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
[Homo sapiens]
Length = 302
Score = 297 bits (761), Expect = 2e-80
Identities = 136/194 (70%), Positives = 158/194 (81%), Gaps = 5/194 (2%)
Query: 126 DAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANTVKFRCP 180
DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVKF+CP
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSI
Sbjct: 91 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150
Query: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
NHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E NGSK
Sbjct: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
Query: 301 YGPDGLPYLKVLKV 314
GPD LPY+++LKV
Sbjct: 211 IGPDNLPYVQILKV 224
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 289 bits (739), Expect = 7e-78
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 351 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 410
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 571 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 628
Query: 411 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 465
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 629 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 688
Query: 466 ---------------------------------PGMEY----------SYDINRVPEEQM 482
PG+ Y S I E +
Sbjct: 689 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 748
Query: 483 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 530
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 749 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 808
Query: 531 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 590
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 809 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 868
Query: 591 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 649
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 869 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 928
Query: 650 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 685
N Y +L+ +P+ +S S+ SS + D
Sbjct: 929 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 971
Score = 30.0 bits (66), Expect = 7.7
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 7/80 (8%)
Query: 215 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHR--PILQAGLPANASTVVGG 272
+L + S +D G + C N +GS N T L+VV++ P++ + N G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVND----GE 329
Query: 273 DVEFVCKVYSDAQP-HIQWI 291
+V+ + + + +P H QWI
Sbjct: 330 NVDLIVEYEAFPKPEHQQWI 349
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 289 bits (739), Expect = 7e-78
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 351 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 410
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632
Query: 411 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 465
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
Query: 466 ---------------------------------PGMEY----------SYDINRVPEEQM 482
PG+ Y S I E +
Sbjct: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752
Query: 483 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 530
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812
Query: 531 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 590
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872
Query: 591 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 649
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932
Query: 650 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 685
N Y +L+ +P+ +S S+ SS + D
Sbjct: 933 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 975
Score = 30.0 bits (66), Expect = 7.7
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 7/80 (8%)
Query: 215 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHR--PILQAGLPANASTVVGG 272
+L + S +D G + C N +GS N T L+VV++ P++ + N G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVND----GE 329
Query: 273 DVEFVCKVYSDAQP-HIQWI 291
+V+ + + + +P H QWI
Sbjct: 330 NVDLIVEYEAFPKPEHQQWI 349
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 244 bits (624), Expect = 2e-64
Identities = 134/295 (45%), Positives = 186/295 (63%), Gaps = 10/295 (3%)
Query: 363 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 422
+ +T +GEG FGQV+ A I KD K + A+KMLK+ A+E D D E+E++
Sbjct: 837 EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891
Query: 423 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 482
+G H NIINLLGAC G LY+ +EYA GNL ++LR R + ++ +
Sbjct: 892 CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951
Query: 483 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 542
+ + L+ A GM+YL+ ++ IHRDLAARNVLV EN KIADFGL+R + Y
Sbjct: 952 SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008
Query: 543 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 602
K T GRLPV+WMA E+L VYT +SDVWSFGVL+WEI +LGG+PY G+ EL++ L +
Sbjct: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068
Query: 603 GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLS 657
G+RM++P NC +E+Y +MR CW P +RP F Q+ L R+ L + Y+++S
Sbjct: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMS 1121
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 244 bits (623), Expect = 2e-64
Identities = 128/275 (46%), Positives = 182/275 (66%), Gaps = 8/275 (2%)
Query: 371 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 430
+GEG FGQV+ A I KD + + A+K +K+ A++ D D E+E++ +G H N
Sbjct: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
Query: 431 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 490
IINLLGAC G LY+ +EYA GNL ++LR R + ++ I ++ + L+
Sbjct: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
Query: 491 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 550
+ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R + Y K T GRLP
Sbjct: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
Query: 551 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 610
V+WMA E+L VYT SDVWS+GVL+WEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
Query: 611 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 645
NC +E+Y +MR CW P +RP+F Q++ L+R+L
Sbjct: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,465,045
Number of Sequences: 37866
Number of extensions: 1395827
Number of successful extensions: 9056
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 667
Number of HSP's successfully gapped in prelim test: 346
Number of HSP's that attempted gapping in prelim test: 4120
Number of HSP's gapped (non-prelim): 2957
length of query: 705
length of database: 18,247,518
effective HSP length: 109
effective length of query: 596
effective length of database: 14,120,124
effective search space: 8415593904
effective search space used: 8415593904
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.