Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 222144237

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
         (706 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu...  1450   0.0  
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu...  1441   0.0  
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu...  1378   0.0  
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu...  1321   0.0  
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu...  1319   0.0  
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu...  1258   0.0  
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu...  1203   0.0  
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur...  1117   0.0  
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur...  1115   0.0  
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur...  1112   0.0  
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu...  1111   0.0  
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu...  1025   0.0  
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs...  1013   0.0  
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur...  1012   0.0  
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu...   957   0.0  
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu...   879   0.0  
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur...   862   0.0  
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur...   862   0.0  
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur...   844   0.0  
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur...   642   0.0  
gi|10862701 ret proto-oncogene isoform c [Homo sapiens]               329   5e-90
gi|10862703 ret proto-oncogene isoform a [Homo sapiens]               329   5e-90
gi|11321597 kinase insert domain receptor precursor [Homo sapiens]    328   1e-89
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [...   320   3e-87
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur...   289   7e-78
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge...   289   7e-78
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene...   289   7e-78
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur...   287   3e-77
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like...   244   2e-64
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap...   244   2e-64

>gi|222144237 fibroblast growth factor receptor 2 isoform 6
           precursor [Homo sapiens]
          Length = 706

 Score = 1450 bits (3753), Expect = 0.0
 Identities = 706/706 (100%), Positives = 706/706 (100%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60

Query: 61  KFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN 120
           KFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN
Sbjct: 61  KFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN 120

Query: 121 EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVE 180
           EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVE
Sbjct: 121 EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVE 180

Query: 181 KNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSA 240
           KNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSA
Sbjct: 181 KNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSA 240

Query: 241 WLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAV 300
           WLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAV
Sbjct: 241 WLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAV 300

Query: 301 HKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE 360
           HKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE
Sbjct: 301 HKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE 360

Query: 361 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 420
           FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM
Sbjct: 361 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 420

Query: 421 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 480
           EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE
Sbjct: 421 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 480

Query: 481 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 540
           EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID
Sbjct: 481 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 540

Query: 541 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKL 600
           YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKL
Sbjct: 541 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKL 600

Query: 601 LKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQP 660
           LKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQP
Sbjct: 601 LKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQP 660

Query: 661 LEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 706
           LEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
Sbjct: 661 LEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 706


>gi|222144241 fibroblast growth factor receptor 2 isoform 8
           precursor [Homo sapiens]
          Length = 704

 Score = 1441 bits (3731), Expect = 0.0
 Identities = 704/706 (99%), Positives = 704/706 (99%), Gaps = 2/706 (0%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60

Query: 61  KFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN 120
           KFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN
Sbjct: 61  KFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN 120

Query: 121 EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVE 180
           EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVE
Sbjct: 121 EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVE 180

Query: 181 KNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSA 240
           KNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSA
Sbjct: 181 KNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSA 240

Query: 241 WLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAV 300
           WLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAV
Sbjct: 241 WLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAV 300

Query: 301 HKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE 360
           HKLTKRIPLRRQV  SAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE
Sbjct: 301 HKLTKRIPLRRQV--SAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWE 358

Query: 361 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 420
           FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM
Sbjct: 359 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 418

Query: 421 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 480
           EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE
Sbjct: 419 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 478

Query: 481 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 540
           EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID
Sbjct: 479 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 538

Query: 541 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKL 600
           YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKL
Sbjct: 539 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKL 598

Query: 601 LKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQP 660
           LKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQP
Sbjct: 599 LKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQP 658

Query: 661 LEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 706
           LEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
Sbjct: 659 LEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 704


>gi|221316639 fibroblast growth factor receptor 2 isoform 1
           precursor [Homo sapiens]
          Length = 821

 Score = 1378 bits (3566), Expect = 0.0
 Identities = 669/669 (100%), Positives = 669/669 (100%)

Query: 38  APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
           APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ
Sbjct: 153 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 212

Query: 98  HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
           HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG
Sbjct: 213 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 272

Query: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
           DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV
Sbjct: 273 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 332

Query: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV 277
           TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV
Sbjct: 333 TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV 392

Query: 278 VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLS 337
           VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLS
Sbjct: 393 VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLS 452

Query: 338 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 397
           STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV
Sbjct: 453 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 512

Query: 398 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 457
           TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 513 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 572

Query: 458 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 517
           REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV
Sbjct: 573 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 632

Query: 518 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 577
           LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL
Sbjct: 633 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 692

Query: 578 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 637
           MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ
Sbjct: 693 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 752

Query: 638 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQY 697
           LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQY
Sbjct: 753 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQY 812

Query: 698 PHINGSVKT 706
           PHINGSVKT
Sbjct: 813 PHINGSVKT 821



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 78/273 (28%), Positives = 114/273 (41%), Gaps = 52/273 (19%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE  P  T  +  +  ++      ++
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58

Query: 61  KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117
           + RC         + W K+G      +R   IG Y        L ++   P D G Y C 
Sbjct: 59  EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108

Query: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152
                 S    + ++V +                         R+P+    +       +
Sbjct: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168

Query: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
                 V+F C    +  P ++W+    KNG ++  +        +  G    ++    L
Sbjct: 169 VPAANTVKFRCPAGGNPMPTMRWL----KNGKEFKQEH-------RIGGYKVRNQHWS-L 216

Query: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
            + +V   D G YTC+  N  G   H+  L V+
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249


>gi|222144235 fibroblast growth factor receptor 2 isoform 5
           precursor [Homo sapiens]
          Length = 707

 Score = 1321 bits (3420), Expect = 0.0
 Identities = 655/701 (93%), Positives = 660/701 (94%), Gaps = 26/701 (3%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGA---------------------- 38
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE A                      
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60

Query: 39  ----PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
               PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV
Sbjct: 61  NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 120

Query: 95  RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
           RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV
Sbjct: 121 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180

Query: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
           VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI
Sbjct: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 240

Query: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 274
           RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA
Sbjct: 241 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 300

Query: 275 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 334
           CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT
Sbjct: 301 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 360

Query: 335 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 394
           RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK
Sbjct: 361 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 420

Query: 395 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 454
           EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
Sbjct: 421 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 480

Query: 455 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 514
           GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
Sbjct: 481 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 540

Query: 515 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 574
           RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF
Sbjct: 541 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 600

Query: 575 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 634
           GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT
Sbjct: 601 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 660

Query: 635 FKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSC 675
           FKQLVEDLDRILTLTTNEE   +S  ++ + P    +   C
Sbjct: 661 FKQLVEDLDRILTLTTNEEEKKVSGAVDCHKPPCNPSHLPC 701


>gi|221316638 fibroblast growth factor receptor 2 isoform 2
           precursor [Homo sapiens]
          Length = 822

 Score = 1319 bits (3414), Expect = 0.0
 Identities = 645/672 (95%), Positives = 653/672 (97%), Gaps = 5/672 (0%)

Query: 38  APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
           APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ
Sbjct: 153 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 212

Query: 98  HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
           HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG
Sbjct: 213 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 272

Query: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
           DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK +G+N+++ E+  L+  NV
Sbjct: 273 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALF--NV 330

Query: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLP---APGREKEITASPDYLEIAIYCIGVFLIA 274
           T  DAGEY C   N IG +  SAWLTVLP   APGREKEITASPDYLEIAIYCIGVFLIA
Sbjct: 331 TEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIA 390

Query: 275 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 334
           CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT
Sbjct: 391 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 450

Query: 335 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 394
           RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK
Sbjct: 451 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 510

Query: 395 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 454
           EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
Sbjct: 511 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 570

Query: 455 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 514
           GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
Sbjct: 571 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 630

Query: 515 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 574
           RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF
Sbjct: 631 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 690

Query: 575 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 634
           GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT
Sbjct: 691 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 750

Query: 635 FKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCL 694
           FKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCL
Sbjct: 751 FKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCL 810

Query: 695 PQYPHINGSVKT 706
           PQYPHINGSVKT
Sbjct: 811 PQYPHINGSVKT 822



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 78/273 (28%), Positives = 114/273 (41%), Gaps = 52/273 (19%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE  P  T  +  +  ++      ++
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58

Query: 61  KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117
           + RC         + W K+G      +R   IG Y        L ++   P D G Y C 
Sbjct: 59  EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108

Query: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152
                 S    + ++V +                         R+P+    +       +
Sbjct: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168

Query: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
                 V+F C    +  P ++W+    KNG ++  +        +  G    ++    L
Sbjct: 169 VPAANTVKFRCPAGGNPMPTMRWL----KNGKEFKQEH-------RIGGYKVRNQHWS-L 216

Query: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
            + +V   D G YTC+  N  G   H+  L V+
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249


>gi|222144244 fibroblast growth factor receptor 2 isoform 9
           precursor [Homo sapiens]
          Length = 680

 Score = 1258 bits (3256), Expect = 0.0
 Identities = 627/681 (92%), Positives = 635/681 (93%), Gaps = 31/681 (4%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGA---------------------- 38
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE A                      
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60

Query: 39  ----PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
               PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV
Sbjct: 61  NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 120

Query: 95  RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
           RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV
Sbjct: 121 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180

Query: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
           VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK +G+N+++ E+  L+ 
Sbjct: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALF- 239

Query: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP---APGREKEITASPDYLEIAIYCIGVF 271
            NVT  DAGEY C   N IG +  SAWLTVLP   APGREKEITASPDYLEIAIYCIGVF
Sbjct: 240 -NVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVF 298

Query: 272 LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 331
           LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR
Sbjct: 299 LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 358

Query: 332 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 391
           ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD
Sbjct: 359 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 418

Query: 392 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 451
           KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY
Sbjct: 419 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 478

Query: 452 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 511
           ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD
Sbjct: 479 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 538

Query: 512 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 571
           LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV
Sbjct: 539 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 598

Query: 572 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 631
           WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ
Sbjct: 599 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 658

Query: 632 RPTFKQLVEDLDRILTLTTNE 652
           RPTFKQLVEDLDRILTLTTNE
Sbjct: 659 RPTFKQLVEDLDRILTLTTNE 679


>gi|222144231 fibroblast growth factor receptor 2 isoform 3
           precursor [Homo sapiens]
          Length = 769

 Score = 1203 bits (3113), Expect = 0.0
 Identities = 591/618 (95%), Positives = 599/618 (96%), Gaps = 5/618 (0%)

Query: 38  APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
           APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ
Sbjct: 153 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 212

Query: 98  HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
           HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG
Sbjct: 213 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 272

Query: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
           DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK +G+N+++ E+  L+  NV
Sbjct: 273 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALF--NV 330

Query: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLP---APGREKEITASPDYLEIAIYCIGVFLIA 274
           T  DAGEY C   N IG +  SAWLTVLP   APGREKEITASPDYLEIAIYCIGVFLIA
Sbjct: 331 TEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIA 390

Query: 275 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 334
           CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT
Sbjct: 391 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 450

Query: 335 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 394
           RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK
Sbjct: 451 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 510

Query: 395 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 454
           EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
Sbjct: 511 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 570

Query: 455 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 514
           GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
Sbjct: 571 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 630

Query: 515 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 574
           RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF
Sbjct: 631 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 690

Query: 575 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 634
           GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT
Sbjct: 691 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 750

Query: 635 FKQLVEDLDRILTLTTNE 652
           FKQLVEDLDRILTLTTNE
Sbjct: 751 FKQLVEDLDRILTLTTNE 768



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 78/273 (28%), Positives = 114/273 (41%), Gaps = 52/273 (19%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE  P  T  +  +  ++      ++
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58

Query: 61  KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117
           + RC         + W K+G      +R   IG Y        L ++   P D G Y C 
Sbjct: 59  EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108

Query: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152
                 S    + ++V +                         R+P+    +       +
Sbjct: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168

Query: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
                 V+F C    +  P ++W+    KNG ++  +        +  G    ++    L
Sbjct: 169 VPAANTVKFRCPAGGNPMPTMRWL----KNGKEFKQEH-------RIGGYKVRNQHWS-L 216

Query: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
            + +V   D G YTC+  N  G   H+  L V+
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249


>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
           [Homo sapiens]
          Length = 731

 Score = 1117 bits (2890), Expect = 0.0
 Identities = 549/731 (75%), Positives = 617/731 (84%), Gaps = 28/731 (3%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVE-----------------------DTTLEPEG 37
           M SW   +   V+  ATL  ARPS +L E                       D T     
Sbjct: 1   MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60

Query: 38  APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
           APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR  
Sbjct: 61  APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120

Query: 98  HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
            WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN +  +G 
Sbjct: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 180

Query: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
           +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV
Sbjct: 181 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 240

Query: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV 277
           +FEDAGEYTCLAGNSIG+S HSAWLTVL A      +  SP YLEI IYC G FLI+CMV
Sbjct: 241 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 300

Query: 278 VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLS 337
            +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS   LVR  +RLS
Sbjct: 301 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLS 359

Query: 338 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 397
           S+  TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP    
Sbjct: 360 SSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 418

Query: 398 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 457
            VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 419 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 478

Query: 458 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 517
           REYL+ARRPPG+EY Y+ +  PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNV
Sbjct: 479 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 538

Query: 518 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 577
           LVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL
Sbjct: 539 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 598

Query: 578 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 637
           +WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQ
Sbjct: 599 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 658

Query: 638 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQ 696
           LVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP+
Sbjct: 659 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 718

Query: 697 YPH--INGSVK 705
           +P    NG +K
Sbjct: 719 HPAQLANGGLK 729


>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
           [Homo sapiens]
          Length = 733

 Score = 1115 bits (2885), Expect = 0.0
 Identities = 548/733 (74%), Positives = 616/733 (84%), Gaps = 30/733 (4%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEG----------------------- 37
           M SW   +   V+  ATL  ARPS +L E   L                           
Sbjct: 1   MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60

Query: 38  --APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVR 95
             APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR
Sbjct: 61  PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120

Query: 96  NQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV 155
              WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN +  +
Sbjct: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 180

Query: 156 GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIR 215
           G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++R
Sbjct: 181 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLR 240

Query: 216 NVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIAC 275
           NV+FEDAGEYTCLAGNSIG+S HSAWLTVL A      +  SP YLEI IYC G FLI+C
Sbjct: 241 NVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISC 300

Query: 276 MVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTR 335
           MV +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS   LVR  +R
Sbjct: 301 MVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSR 359

Query: 336 LSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKE 395
           LSS+  TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP  
Sbjct: 360 LSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNR 418

Query: 396 AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 455
              VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG
Sbjct: 419 VTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 478

Query: 456 NLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAAR 515
           NLREYL+ARRPPG+EY Y+ +  PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAAR
Sbjct: 479 NLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAAR 538

Query: 516 NVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 575
           NVLVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFG
Sbjct: 539 NVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFG 598

Query: 576 VLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF 635
           VL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTF
Sbjct: 599 VLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF 658

Query: 636 KQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCL 694
           KQLVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCL
Sbjct: 659 KQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCL 718

Query: 695 PQYPH--INGSVK 705
           P++P    NG +K
Sbjct: 719 PRHPAQLANGGLK 731


>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score = 1112 bits (2875), Expect = 0.0
 Identities = 536/679 (78%), Positives = 601/679 (88%), Gaps = 5/679 (0%)

Query: 30  DTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRI 89
           D T     APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRI
Sbjct: 142 DNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRI 201

Query: 90  GGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPA 149
           GGYKVR   WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPA
Sbjct: 202 GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPA 261

Query: 150 NASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEI 209
           N +  +G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+
Sbjct: 262 NKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM 321

Query: 210 EVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIG 269
           EVL++RNV+FEDAGEYTCLAGNSIG+S HSAWLTVL A      +  SP YLEI IYC G
Sbjct: 322 EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTG 381

Query: 270 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPL 329
            FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS   L
Sbjct: 382 AFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLL 441

Query: 330 VRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 389
           VR  +RLSS+  TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+D
Sbjct: 442 VR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLD 499

Query: 390 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 449
           KDKP     VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIV
Sbjct: 500 KDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 559

Query: 450 EYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIH 509
           EYASKGNLREYL+ARRPPG+EY Y+ +  PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIH
Sbjct: 560 EYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIH 619

Query: 510 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 569
           RDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQS
Sbjct: 620 RDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQS 679

Query: 570 DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVP 629
           DVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVP
Sbjct: 680 DVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVP 739

Query: 630 SQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPM 688
           SQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+
Sbjct: 740 SQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPL 799

Query: 689 PYEPCLPQYPH--INGSVK 705
           P EPCLP++P    NG +K
Sbjct: 800 PEEPCLPRHPAQLANGGLK 818



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 62/275 (22%), Positives = 104/275 (37%), Gaps = 59/275 (21%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
           M SW   +   V+  ATL  ARPS +L E    +P GAP       +E     V   + +
Sbjct: 1   MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAP-------VEVESFLVHPGDLL 51

Query: 61  KFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118
           + RC    + + ++ WL++G +  + +R  I G +V        ++  VP+D G Y CV 
Sbjct: 52  QLRCRLRDD-VQSINWLRDGVQLAESNRTRITGEEVE-------VQDSVPADSGLYACVT 103

Query: 119 ENEYGSINHTYHLDVVERSPH----------------------RPILQAGLPANA----- 151
            +  GS    + ++V +  P                        P+              
Sbjct: 104 SSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKL 163

Query: 152 -STVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIE 210
            +      V+F C       P ++W+    KNG ++ PD        +  G         
Sbjct: 164 HAVPAAKTVKFKCPSSGTPNPTLRWL----KNGKEFKPDH-------RIGGYKVRYATWS 212

Query: 211 VLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
           ++ + +V   D G YTC+  N  G   H+  L V+
Sbjct: 213 II-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVV 246


>gi|105990522 fibroblast growth factor receptor 1 isoform 1
           precursor [Homo sapiens]
          Length = 822

 Score = 1111 bits (2873), Expect = 0.0
 Identities = 534/671 (79%), Positives = 599/671 (89%), Gaps = 5/671 (0%)

Query: 38  APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
           APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR  
Sbjct: 152 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 211

Query: 98  HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
            WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN +  +G 
Sbjct: 212 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 271

Query: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
           +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV
Sbjct: 272 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331

Query: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV 277
           +FEDAGEYTCLAGNSIG+S HSAWLTVL A      +  SP YLEI IYC G FLI+CMV
Sbjct: 332 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 391

Query: 278 VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLS 337
            +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS   LVR  +RLS
Sbjct: 392 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLS 450

Query: 338 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 397
           S+  TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP    
Sbjct: 451 SSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 509

Query: 398 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 457
            VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 510 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 569

Query: 458 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 517
           REYL+ARRPPG+EY Y+ +  PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNV
Sbjct: 570 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 629

Query: 518 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 577
           LVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL
Sbjct: 630 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 689

Query: 578 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 637
           +WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQ
Sbjct: 690 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 749

Query: 638 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQ 696
           LVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP+
Sbjct: 750 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 809

Query: 697 YPH--INGSVK 705
           +P    NG +K
Sbjct: 810 HPAQLANGGLK 820



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 64/277 (23%), Positives = 105/277 (37%), Gaps = 61/277 (22%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
           M SW   +   V+  ATL  ARPS +L E    +P GAP       +E     V   + +
Sbjct: 1   MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAP-------VEVESFLVHPGDLL 51

Query: 61  KFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118
           + RC    + + ++ WL++G +  + +R  I G +V        ++  VP+D G Y CV 
Sbjct: 52  QLRCRLRDD-VQSINWLRDGVQLAESNRTRITGEEVE-------VQDSVPADSGLYACVT 103

Query: 119 ENEYGSINHTYHLDVVERSPH--------------------RPILQAGLPANAS------ 152
            +  GS    + ++V +  P                     +P      P   S      
Sbjct: 104 SSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEK 163

Query: 153 ----TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKE 208
                     V+F C       P ++W+    KNG ++ PD        +  G       
Sbjct: 164 KLHAVPAAKTVKFKCPSSGTPNPTLRWL----KNGKEFKPDH-------RIGGYKVRYAT 212

Query: 209 IEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
             ++ + +V   D G YTC+  N  G   H+  L V+
Sbjct: 213 WSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVV 248


>gi|222144233 fibroblast growth factor receptor 2 isoform 4
           precursor [Homo sapiens]
          Length = 709

 Score = 1025 bits (2649), Expect = 0.0
 Identities = 537/734 (73%), Positives = 575/734 (78%), Gaps = 53/734 (7%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE  P  T  +  +  ++      ++
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58

Query: 61  KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117
           + RC         + W K+G      +R   IG Y        L ++   P D G Y C 
Sbjct: 59  EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108

Query: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152
                 S    + ++V +                         R+P+    +       +
Sbjct: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168

Query: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
                 V+F C    +  P ++W+K    NG ++  +        +  G    ++   ++
Sbjct: 169 VPAANTVKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI 217

Query: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFL 272
            + +V   D G YTC+  N  G   H+  L V+ APGREKEITASPDYLEIAIYCIGVFL
Sbjct: 218 -MESVVPSDKGNYTCVVENEYGSINHTYHLDVV-APGREKEITASPDYLEIAIYCIGVFL 275

Query: 273 IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI 332
           IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI
Sbjct: 276 IACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI 335

Query: 333 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 392
           TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK
Sbjct: 336 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 395

Query: 393 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 452
           PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA
Sbjct: 396 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 455

Query: 453 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 512
           SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL
Sbjct: 456 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 515

Query: 513 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 572
           AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW
Sbjct: 516 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 575

Query: 573 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 632
           SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR
Sbjct: 576 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 635

Query: 633 PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 692
           PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP
Sbjct: 636 PTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 695

Query: 693 CLPQYPHINGSVKT 706
           CLPQYPHINGSVKT
Sbjct: 696 CLPQYPHINGSVKT 709


>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
           [Homo sapiens]
          Length = 806

 Score = 1013 bits (2618), Expect = 0.0
 Identities = 501/668 (75%), Positives = 569/668 (85%), Gaps = 15/668 (2%)

Query: 29  EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
           EDT ++  GAPYWT  E+M+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHR
Sbjct: 142 EDTGVDT-GAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHR 200

Query: 89  IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLP 148
           IGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI  TY LDV+ERSPHRPILQAGLP
Sbjct: 201 IGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLP 260

Query: 149 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKE 208
           AN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG PY+ VLK AG NTTDKE
Sbjct: 261 ANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKE 320

Query: 209 IEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPD----YLEIA 264
           +EVL + NVTFEDAGEYTCLAGNSIG S HSAWL VLPA   E+E+  + +    Y  I 
Sbjct: 321 LEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPA---EEELVEADEAGSVYAGIL 377

Query: 265 IYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMN 324
            Y +G FL   +V  V LCR+++  KK      P VHK++ R PL+RQV  S ES++SM+
Sbjct: 378 SYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMS 432

Query: 325 SNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAE 384
           SNTPLVRI  RLSS  + P LA VSE ELP DPKWE  R +LTLGKPLGEGCFGQVVMAE
Sbjct: 433 SNTPLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAE 490

Query: 385 AVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGP 444
           A+GIDKD+  + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GP
Sbjct: 491 AIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGP 550

Query: 445 LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS 504
           LYV+VEYA+KGNLRE+LRARRPPG++YS+D  + PEEQ+TFKDLVSC YQ+ARGMEYLAS
Sbjct: 551 LYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLAS 610

Query: 505 QKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRV 564
           QKCIHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRV
Sbjct: 611 QKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRV 670

Query: 565 YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDC 624
           YTHQSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+C
Sbjct: 671 YTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMREC 730

Query: 625 WHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFS 684
           WHA PSQRPTFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP   DT SS SSGDDSVF+
Sbjct: 731 WHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFA 790

Query: 685 PDPMPYEP 692
            D +P  P
Sbjct: 791 HDLLPPAP 798


>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
           [Homo sapiens]
          Length = 785

 Score = 1012 bits (2616), Expect = 0.0
 Identities = 498/671 (74%), Positives = 562/671 (83%), Gaps = 42/671 (6%)

Query: 38  APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
           APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR  
Sbjct: 152 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 211

Query: 98  HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
            WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN +  +G 
Sbjct: 212 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 271

Query: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
           +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV
Sbjct: 272 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331

Query: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMV 277
           +FEDAGEYTCLAGNSIG+S HSAWLTVL A      +  SP YLEI IYC G FLI+CMV
Sbjct: 332 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 391

Query: 278 VTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLS 337
            +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS   LVR  +RLS
Sbjct: 392 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLS 450

Query: 338 STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV 397
           S+  TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP    
Sbjct: 451 SSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 509

Query: 398 TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 457
            VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
Sbjct: 510 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 569

Query: 458 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 517
           REYL+ARRPPG+EY Y+ +  PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNV
Sbjct: 570 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 629

Query: 518 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 577
           LVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL
Sbjct: 630 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 689

Query: 578 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 637
           +WEIFTLGGSPYPG+PVEEL                                     FKQ
Sbjct: 690 LWEIFTLGGSPYPGVPVEEL-------------------------------------FKQ 712

Query: 638 LVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQ 696
           LVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP+
Sbjct: 713 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPR 772

Query: 697 YPH--INGSVK 705
           +P    NG +K
Sbjct: 773 HPAQLANGGLK 783



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 64/277 (23%), Positives = 105/277 (37%), Gaps = 61/277 (22%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
           M SW   +   V+  ATL  ARPS +L E    +P GAP       +E     V   + +
Sbjct: 1   MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAP-------VEVESFLVHPGDLL 51

Query: 61  KFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118
           + RC    + + ++ WL++G +  + +R  I G +V        ++  VP+D G Y CV 
Sbjct: 52  QLRCRLRDD-VQSINWLRDGVQLAESNRTRITGEEVE-------VQDSVPADSGLYACVT 103

Query: 119 ENEYGSINHTYHLDVVERSPH--------------------RPILQAGLPANAS------ 152
            +  GS    + ++V +  P                     +P      P   S      
Sbjct: 104 SSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEK 163

Query: 153 ----TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKE 208
                     V+F C       P ++W+    KNG ++ PD        +  G       
Sbjct: 164 KLHAVPAAKTVKFKCPSSGTPNPTLRWL----KNGKEFKPDH-------RIGGYKVRYAT 212

Query: 209 IEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
             ++ + +V   D G YTC+  N  G   H+  L V+
Sbjct: 213 WSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVV 248


>gi|254028242 fibroblast growth factor receptor 3 isoform 3
           precursor [Homo sapiens]
          Length = 808

 Score =  957 bits (2474), Expect = 0.0
 Identities = 476/668 (71%), Positives = 553/668 (82%), Gaps = 13/668 (1%)

Query: 29  EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
           EDT ++  GAPYWT  E+M+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHR
Sbjct: 142 EDTGVDT-GAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHR 200

Query: 89  IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLP 148
           IGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI  TY LDV+ERSPHRPILQAGLP
Sbjct: 201 IGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLP 260

Query: 149 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKE 208
           AN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG PY+ VLK+    + + +
Sbjct: 261 ANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEAD 320

Query: 209 IEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPD----YLEIA 264
           +  L + NV+  D GEY C A N IG++  + WL+V      E+E+  + +    Y  I 
Sbjct: 321 VR-LRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGIL 379

Query: 265 IYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMN 324
            Y +G FL   +V  V LCR+++  KK      P VHK++ R PL+RQV  S ES++SM+
Sbjct: 380 SYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMS 434

Query: 325 SNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAE 384
           SNTPLVRI  RLSS  + P LA VSE ELP DPKWE  R +LTLGKPLGEGCFGQVVMAE
Sbjct: 435 SNTPLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAE 492

Query: 385 AVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGP 444
           A+GIDKD+  + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GP
Sbjct: 493 AIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGP 552

Query: 445 LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS 504
           LYV+VEYA+KGNLRE+LRARRPPG++YS+D  + PEEQ+TFKDLVSC YQ+ARGMEYLAS
Sbjct: 553 LYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLAS 612

Query: 505 QKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRV 564
           QKCIHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRV
Sbjct: 613 QKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRV 672

Query: 565 YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDC 624
           YTHQSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+C
Sbjct: 673 YTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMREC 732

Query: 625 WHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFS 684
           WHA PSQRPTFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP   DT SS SSGDDSVF+
Sbjct: 733 WHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFA 792

Query: 685 PDPMPYEP 692
            D +P  P
Sbjct: 793 HDLLPPAP 800


>gi|222144239 fibroblast growth factor receptor 2 isoform 7
           precursor [Homo sapiens]
          Length = 705

 Score =  879 bits (2270), Expect = 0.0
 Identities = 479/742 (64%), Positives = 528/742 (71%), Gaps = 73/742 (9%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
           MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE  P  T  +  +  ++      ++
Sbjct: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58

Query: 61  KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117
           + RC         + W K+G      +R   IG Y        L ++   P D G Y C 
Sbjct: 59  EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108

Query: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152
                 S    + ++V +                         R+P+    +       +
Sbjct: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168

Query: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
                 V+F C    +  P ++W+K    NG ++  +        +  G    ++   ++
Sbjct: 169 VPAANTVKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI 217

Query: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFL 272
            + +V   D G YTC+  N  G   H+  L V+        + A            G+  
Sbjct: 218 -MESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQA------------GLPA 264

Query: 273 IACMVV---TVILCRMKNTTKKPDFSSQPAVHKLTKR-----IPLRRQVTVSAESSSSMN 324
            A  VV      +C++ +  + P       V K   +     +P  + + VSAESSSSMN
Sbjct: 265 NASTVVGGDVEFVCKVYSDAQ-PHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESSSSMN 323

Query: 325 SNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAE 384
           SNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAE
Sbjct: 324 SNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAE 383

Query: 385 AVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGP 444
           AVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGP
Sbjct: 384 AVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGP 443

Query: 445 LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS 504
           LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS
Sbjct: 444 LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS 503

Query: 505 QKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRV 564
           QKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRV
Sbjct: 504 QKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRV 563

Query: 565 YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDC 624
           YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDC
Sbjct: 564 YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDC 623

Query: 625 WHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFS 684
           WHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFS
Sbjct: 624 WHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFS 683

Query: 685 PDPMPYEPCLPQYPHINGSVKT 706
           PDPMPYEPCLPQYPHINGSVKT
Sbjct: 684 PDPMPYEPCLPQYPHINGSVKT 705


>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
           [Homo sapiens]
          Length = 802

 Score =  862 bits (2228), Expect = 0.0
 Identities = 436/660 (66%), Positives = 524/660 (79%), Gaps = 19/660 (2%)

Query: 35  PEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
           P+ APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F  E+RIGG ++
Sbjct: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRL 202

Query: 95  RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
           R+QHWSL+MESVVPSD+G YTC+VEN  GSI + Y LDV+ERSPHRPILQAGLPAN + V
Sbjct: 203 RHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV 262

Query: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
           VG DVE +CKVYSDAQPHIQW+KH+  NGS +G DG PY++VLK A +N++  E+EVLY+
Sbjct: 263 VGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYL 320

Query: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEIT---ASPD--YLEIAIYCIG 269
           RNV+ EDAGEYTCLAGNSIG+S+ SAWLTVLP    E++ T   A+P+  Y +I +Y  G
Sbjct: 321 RNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP----EEDPTWTAAAPEARYTDIILYASG 376

Query: 270 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPL 329
              +A +++   L R +    +      PA  +   R PL RQ   S ES SS  S++ L
Sbjct: 377 SLALAVLLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQF--SLESGSSGKSSSSL 432

Query: 330 VRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 389
           VR   RLSS+    +LAG+   +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D
Sbjct: 433 VR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMD 490

Query: 390 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 449
             +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIV
Sbjct: 491 PARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIV 550

Query: 450 EYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIH 509
           E A+KGNLRE+LRARRPPG + S D  R  E  ++F  LVSC YQ+ARGM+YL S+KCIH
Sbjct: 551 ECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIH 610

Query: 510 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 569
           RDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQS
Sbjct: 611 RDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQS 670

Query: 570 DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVP 629
           DVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C  ELY +MR+CWHA P
Sbjct: 671 DVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAP 730

Query: 630 SQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 689
           SQRPTFKQLVE LD++L L  +EEYLDL      YSPS  D  S+CSS  DSVFS DP+P
Sbjct: 731 SQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDASSTCSS-SDSVFSHDPLP 788



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 58/246 (23%), Positives = 88/246 (35%), Gaps = 48/246 (19%)

Query: 24  SFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEF 83
           S    E+  LEP  AP   + E+ E+ L  V     V+  C   G       W K G   
Sbjct: 21  SLEASEEVELEPCLAP---SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRL 73

Query: 84  KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH---------TYHLDVV 134
               R+ G++ R     L + S +P D G Y C+       + +         T   D  
Sbjct: 74  APAGRVRGWRGR-----LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDE 128

Query: 135 ERSPHR-PILQAGLPANA--------------STVVGGDVEFVCKVYSDAQPHIQWIKHV 179
           +   HR P  +   P  A              +   G  V+F C    +  P I+W+K  
Sbjct: 129 DPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK-- 186

Query: 180 EKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHS 239
                    DG  +    +  G+    +    L + +V   D G YTCL  N++G   ++
Sbjct: 187 ---------DGQAFHGENRIGGIRLRHQHWS-LVMESVVPSDRGTYTCLVENAVGSIRYN 236

Query: 240 AWLTVL 245
             L VL
Sbjct: 237 YLLDVL 242


>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
           [Homo sapiens]
          Length = 802

 Score =  862 bits (2228), Expect = 0.0
 Identities = 436/660 (66%), Positives = 524/660 (79%), Gaps = 19/660 (2%)

Query: 35  PEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
           P+ APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F  E+RIGG ++
Sbjct: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRL 202

Query: 95  RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
           R+QHWSL+MESVVPSD+G YTC+VEN  GSI + Y LDV+ERSPHRPILQAGLPAN + V
Sbjct: 203 RHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV 262

Query: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
           VG DVE +CKVYSDAQPHIQW+KH+  NGS +G DG PY++VLK A +N++  E+EVLY+
Sbjct: 263 VGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYL 320

Query: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEIT---ASPD--YLEIAIYCIG 269
           RNV+ EDAGEYTCLAGNSIG+S+ SAWLTVLP    E++ T   A+P+  Y +I +Y  G
Sbjct: 321 RNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP----EEDPTWTAAAPEARYTDIILYASG 376

Query: 270 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPL 329
              +A +++   L R +    +      PA  +   R PL RQ   S ES SS  S++ L
Sbjct: 377 SLALAVLLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQF--SLESGSSGKSSSSL 432

Query: 330 VRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 389
           VR   RLSS+    +LAG+   +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D
Sbjct: 433 VR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMD 490

Query: 390 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 449
             +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIV
Sbjct: 491 PARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIV 550

Query: 450 EYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIH 509
           E A+KGNLRE+LRARRPPG + S D  R  E  ++F  LVSC YQ+ARGM+YL S+KCIH
Sbjct: 551 ECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIH 610

Query: 510 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 569
           RDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQS
Sbjct: 611 RDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQS 670

Query: 570 DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVP 629
           DVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C  ELY +MR+CWHA P
Sbjct: 671 DVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAP 730

Query: 630 SQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 689
           SQRPTFKQLVE LD++L L  +EEYLDL      YSPS  D  S+CSS  DSVFS DP+P
Sbjct: 731 SQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDASSTCSS-SDSVFSHDPLP 788



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 58/246 (23%), Positives = 88/246 (35%), Gaps = 48/246 (19%)

Query: 24  SFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEF 83
           S    E+  LEP  AP   + E+ E+ L  V     V+  C   G       W K G   
Sbjct: 21  SLEASEEVELEPCLAP---SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRL 73

Query: 84  KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH---------TYHLDVV 134
               R+ G++ R     L + S +P D G Y C+       + +         T   D  
Sbjct: 74  APAGRVRGWRGR-----LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDE 128

Query: 135 ERSPHR-PILQAGLPANA--------------STVVGGDVEFVCKVYSDAQPHIQWIKHV 179
           +   HR P  +   P  A              +   G  V+F C    +  P I+W+K  
Sbjct: 129 DPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK-- 186

Query: 180 EKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHS 239
                    DG  +    +  G+    +    L + +V   D G YTCL  N++G   ++
Sbjct: 187 ---------DGQAFHGENRIGGIRLRHQHWS-LVMESVVPSDRGTYTCLVENAVGSIRYN 236

Query: 240 AWLTVL 245
             L VL
Sbjct: 237 YLLDVL 242


>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
           [Homo sapiens]
          Length = 762

 Score =  844 bits (2180), Expect = 0.0
 Identities = 427/655 (65%), Positives = 503/655 (76%), Gaps = 49/655 (7%)

Query: 35  PEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
           P+ APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F  E+RIGG ++
Sbjct: 143 PQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRL 202

Query: 95  RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
           R+QHWSL+MESVVPSD+G YTC+VEN  GSI + Y LDV+ERSPHRPILQAGLPAN + V
Sbjct: 203 RHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV 262

Query: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
           VG DVE +CKVYSDAQPHIQW+KH+  NGS +G DG PY++VLK A +N++  E+EVLY+
Sbjct: 263 VGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYL 320

Query: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 274
           RNV+ EDAGEYTCLAGNSIG+S+ SAWLTVLP  GR   +T   D L  A          
Sbjct: 321 RNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHLTC--DSLTPA---------- 368

Query: 275 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 334
                         TK P                       S ES SS  S++ LVR   
Sbjct: 369 ------------GRTKSPTLQ-------------------FSLESGSSGKSSSSLVR-GV 396

Query: 335 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 394
           RLSS+    +LAG+   +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D  +P 
Sbjct: 397 RLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPD 455

Query: 395 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 454
           +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+K
Sbjct: 456 QASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAK 515

Query: 455 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 514
           GNLRE+LRARRPPG + S D  R  E  ++F  LVSC YQ+ARGM+YL S+KCIHRDLAA
Sbjct: 516 GNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAA 575

Query: 515 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 574
           RNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDVWSF
Sbjct: 576 RNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSF 635

Query: 575 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 634
           G+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C  ELY +MR+CWHA PSQRPT
Sbjct: 636 GILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPT 695

Query: 635 FKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 689
           FKQLVE LD++L L  +EEYLDL      YSPS  D  S+CSS  DSVFS DP+P
Sbjct: 696 FKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDASSTCSS-SDSVFSHDPLP 748



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 58/246 (23%), Positives = 88/246 (35%), Gaps = 48/246 (19%)

Query: 24  SFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEF 83
           S    E+  LEP  AP   + E+ E+ L  V     V+  C   G       W K G   
Sbjct: 21  SLEASEEVELEPCLAP---SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRL 73

Query: 84  KQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH---------TYHLDVV 134
               R+ G++ R     L + S +P D G Y C+       + +         T   D  
Sbjct: 74  APAGRVRGWRGR-----LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDE 128

Query: 135 ERSPHR-PILQAGLPANA--------------STVVGGDVEFVCKVYSDAQPHIQWIKHV 179
           +   HR P  +   P  A              +   G  V+F C    +  P I+W+K  
Sbjct: 129 DPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK-- 186

Query: 180 EKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHS 239
                    DG  +    +  G+    +    L + +V   D G YTCL  N++G   ++
Sbjct: 187 ---------DGQAFHGENRIGGIRLRHQHWS-LVMESVVPSDRGTYTCLVENAVGSIRYN 236

Query: 240 AWLTVL 245
             L VL
Sbjct: 237 YLLDVL 242


>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
           [Homo sapiens]
          Length = 694

 Score =  642 bits (1655), Expect = 0.0
 Identities = 341/539 (63%), Positives = 395/539 (73%), Gaps = 29/539 (5%)

Query: 159 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 218
           V F C    +  P I W+K    NG ++  +        +  G+    ++   L + +V 
Sbjct: 172 VRFRCPAAGNPTPSISWLK----NGREFRGEH-------RIGGIKLRHQQWS-LVMESVV 219

Query: 219 FEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVV 278
             D G YTC+  N  G    +  L VL        + A     + A+    V    C V 
Sbjct: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEF-HCKVY 278

Query: 279 TVILCRMKNTTKKPDFSSQPAVHKLTKRI-----PLRRQVTVSAESSSSMNSNTPLVRIT 333
           +           +P       V     ++     P    + VS ES++SM+SNTPLVRI 
Sbjct: 279 S---------DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIA 329

Query: 334 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 393
            RLSS  + P LA VSE ELP DPKWE  R +LTLGKPLGEGCFGQVVMAEA+GIDKD+ 
Sbjct: 330 -RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRA 387

Query: 394 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 453
            + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+
Sbjct: 388 AKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAA 447

Query: 454 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 513
           KGNLRE+LRARRPPG++YS+D  + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLA
Sbjct: 448 KGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 507

Query: 514 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 573
           ARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS
Sbjct: 508 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 567

Query: 574 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 633
           FGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRP
Sbjct: 568 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP 627

Query: 634 TFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 692
           TFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP   DT SS SSGDDSVF+ D +P  P
Sbjct: 628 TFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 686



 Score =  275 bits (702), Expect = 1e-73
 Identities = 126/172 (73%), Positives = 148/172 (86%), Gaps = 1/172 (0%)

Query: 29  EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
           EDT ++  GAPYWT  E+M+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHR
Sbjct: 142 EDTGVDT-GAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHR 200

Query: 89  IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLP 148
           IGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI  TY LDV+ERSPHRPILQAGLP
Sbjct: 201 IGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLP 260

Query: 149 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAA 200
           AN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG PY+ VLK +
Sbjct: 261 ANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVS 312


>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
          Length = 1072

 Score =  329 bits (844), Expect = 5e-90
 Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%)

Query: 319  SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 371
            SS+ M    P        SS+ A  P L        V  +++ EDPKWEFPR  L LGK 
Sbjct: 670  SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729

Query: 372  LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 430
            LGEG FG+VV A A  +   K +    TVAVKMLK++A+  +L DL+SE  ++K +  H 
Sbjct: 730  LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785

Query: 431  NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 482
            ++I L GAC+QDGPL +IVEYA  G+LR +LR  R  G  Y        S  ++   E  
Sbjct: 786  HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845

Query: 483  MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 542
            +T  DL+S  +Q+++GM+YLA  K +HRDLAARN+LV E   MKI+DFGL+RD+   D Y
Sbjct: 846  LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905

Query: 543  KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 602
             K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 906  VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965

Query: 603  EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 662
             GHRM++P NC+ E+Y +M  CW   P +RP F  + +DL+++  +    +YLDL+    
Sbjct: 966  TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023

Query: 663  QYSPSYPD 670
              S  Y D
Sbjct: 1024 SDSLIYDD 1031


>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
          Length = 1114

 Score =  329 bits (844), Expect = 5e-90
 Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%)

Query: 319  SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 371
            SS+ M    P        SS+ A  P L        V  +++ EDPKWEFPR  L LGK 
Sbjct: 670  SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729

Query: 372  LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 430
            LGEG FG+VV A A  +   K +    TVAVKMLK++A+  +L DL+SE  ++K +  H 
Sbjct: 730  LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785

Query: 431  NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 482
            ++I L GAC+QDGPL +IVEYA  G+LR +LR  R  G  Y        S  ++   E  
Sbjct: 786  HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845

Query: 483  MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 542
            +T  DL+S  +Q+++GM+YLA  K +HRDLAARN+LV E   MKI+DFGL+RD+   D Y
Sbjct: 846  LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905

Query: 543  KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 602
             K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 906  VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965

Query: 603  EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 662
             GHRM++P NC+ E+Y +M  CW   P +RP F  + +DL+++  +    +YLDL+    
Sbjct: 966  TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023

Query: 663  QYSPSYPD 670
              S  Y D
Sbjct: 1024 SDSLIYDD 1031


>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
          Length = 1356

 Score =  328 bits (841), Expect = 1e-89
 Identities = 244/648 (37%), Positives = 322/648 (49%), Gaps = 134/648 (20%)

Query: 101  LIMESVVPS--DKGNYTCVVENEYGSINHTY--HLDVVERSPHRPILQAGLPANASTVVG 156
            LIME    S  D+G+Y C+ ++      H     L V+ER    P +   L  N +T +G
Sbjct: 625  LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIG 681

Query: 157  GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 216
              +E  C    +  P I W K    N +     G+    VLK    N T        IR 
Sbjct: 682  ESIEVSCTASGNPPPQIMWFKD---NETLVEDSGI----VLKDGNRNLT--------IRR 726

Query: 217  VTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACM 276
            V  ED G YTC A + +G +   A+  +  A  +          LEI I  +G  +IA  
Sbjct: 727  VRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTN--------LEIIIL-VGTAVIAMF 777

Query: 277  --VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 334
              ++ VI+ R                             TV   +   +         T 
Sbjct: 778  FWLLLVIILR-----------------------------TVKRANGGELK--------TG 800

Query: 335  RLSSTADTPMLAGVSEYE-LPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 392
             LS   D   L      E LP D  KWEFPRD+L LGKPLG G FGQV+ A+A GIDK  
Sbjct: 801  YLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTA 860

Query: 393  PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEY 451
                 TVAVKMLK+ AT  +   L+SE++++  IG H N++NLLGACT+ G PL VIVE+
Sbjct: 861  TCR--TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEF 918

Query: 452  ASKGNLREYLRARRPPGMEYS-----------------YDINR----------------- 477
               GNL  YLR++R   + Y                   D+ R                 
Sbjct: 919  CKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFV 978

Query: 478  -------VPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE 521
                   V EE+         +T + L+  ++Q+A+GME+LAS+KCIHRDLAARN+L++E
Sbjct: 979  EEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE 1038

Query: 522  NNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI 581
             NV+KI DFGLARDI     Y +  + RLP+KWMAPE +FDRVYT QSDVWSFGVL+WEI
Sbjct: 1039 KNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEI 1098

Query: 582  FTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVE 640
            F+LG SPYPG+ ++E F + LKEG RM  P   T E+Y  M DCWH  PSQRPTF +LVE
Sbjct: 1099 FSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVE 1158

Query: 641  DLDRILTLTTNEE-----YLDLSQPL---EQYSPSYPDTRSSCSSGDD 680
             L  +L     ++      L +S+ L   E    S P +  SC   ++
Sbjct: 1159 HLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEE 1206



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 35/124 (28%), Positives = 53/124 (42%), Gaps = 9/124 (7%)

Query: 61  KFRCPAG--GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118
           + R PA   G P P ++W KNG   +  H I     +  H   IME V   D GNYT ++
Sbjct: 347 RVRIPAKYLGYPPPEIKWYKNGIPLESNHTI-----KAGHVLTIME-VSERDTGNYTVIL 400

Query: 119 ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQP-HIQWIK 177
            N       ++ + +V   P +   ++ +    S   G      C VY+   P HI W  
Sbjct: 401 TNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYW 460

Query: 178 HVEK 181
            +E+
Sbjct: 461 QLEE 464



 Score = 37.0 bits (84), Expect = 0.063
 Identities = 27/112 (24%), Positives = 51/112 (45%), Gaps = 12/112 (10%)

Query: 5   GRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRC 64
           G ++CL     A     +    +V   T+    AP  T T  +E +  ++    +++  C
Sbjct: 638 GDYVCL-----AQDRKTKKRHCVVRQLTVLERVAP--TITGNLENQTTSI--GESIEVSC 688

Query: 65  PAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTC 116
            A GNP P + W K+ +   ++    G  +++ + +L +  V   D+G YTC
Sbjct: 689 TASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNLTIRRVRKEDEGLYTC 737



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 35/136 (25%), Positives = 54/136 (39%), Gaps = 24/136 (17%)

Query: 100 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ--AGLPANASTVVGG 157
           +L ++ V  SD+G YTC   +   +  ++  + V E+    P +   +G+ +     VG 
Sbjct: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346

Query: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
            V    K      P I+W K+           G+P          N T K   VL I  V
Sbjct: 347 RVRIPAKYLGYPPPEIKWYKN-----------GIPLES-------NHTIKAGHVLTIMEV 388

Query: 218 TFEDAGEYTCLAGNSI 233
           +  D G YT +  N I
Sbjct: 389 SERDTGNYTVILTNPI 404


>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
            sapiens]
          Length = 1338

 Score =  320 bits (820), Expect = 3e-87
 Identities = 217/614 (35%), Positives = 307/614 (50%), Gaps = 122/614 (19%)

Query: 100  SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 159
            +L + +V   D G Y C   N Y         ++  R    P L   L ++ +  +    
Sbjct: 620  NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISSST 678

Query: 160  EFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTF 219
               C      +P I W K+  K   + G        ++   G +T       L+I  VT 
Sbjct: 679  TLDCHANGVPEPQITWFKNNHKIQQEPG--------IILGPGSST-------LFIERVTE 723

Query: 220  EDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVT 279
            ED G Y C A N  G    SA+LTV     +     ++ + + +   C+   L   +++T
Sbjct: 724  EDEGVYHCKATNQKGSVESSAYLTVQGTSDK-----SNLELITLTCTCVAATLF-WLLLT 777

Query: 280  VILCRMKNTTK--KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLS 337
            + + +MK ++   K D+ S   +      +PL  Q                         
Sbjct: 778  LFIRKMKRSSSEIKTDYLS---IIMDPDEVPLDEQCE----------------------- 811

Query: 338  STADTPMLAGVSEYELPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 396
                           LP D  KWEF R++L LGK LG G FG+VV A A GI K      
Sbjct: 812  --------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR- 856

Query: 397  VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKG 455
             TVAVKMLK+ AT  +   L++E++++  IG H N++NLLGACT Q GPL VIVEY   G
Sbjct: 857  -TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYG 915

Query: 456  NLREYLRARRP--------------------PGMEYSY---------------------- 473
            NL  YL+++R                     PG+E                         
Sbjct: 916  NLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDK 975

Query: 474  DINRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 524
             ++ V EE+         +T +DL+S ++Q+ARGME+L+S+KCIHRDLAARN+L++ENNV
Sbjct: 976  SLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNV 1035

Query: 525  MKIADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 583
            +KI DFGLARDI  N DY +K    RLP+KWMAPE++FD++Y+ +SDVWS+GVL+WEIF+
Sbjct: 1036 VKICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFS 1094

Query: 584  LGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 642
            LGGSPYPG+ ++E F   L+EG RM  P   T E+Y +M DCWH  P +RP F +LVE L
Sbjct: 1095 LGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL 1154

Query: 643  DRILTLTTNEEYLD 656
              +L     ++  D
Sbjct: 1155 GDLLQANVQQDGKD 1168



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 7/105 (6%)

Query: 29  EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
           ++ T+  + APY           H V  +++    C A G P P + W KN  + +QE  
Sbjct: 651 KEITIRDQEAPYLLRNLSD----HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE-- 704

Query: 89  IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDV 133
             G  +     +L +E V   D+G Y C   N+ GS+  + +L V
Sbjct: 705 -PGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTV 748



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 38/160 (23%), Positives = 66/160 (41%), Gaps = 11/160 (6%)

Query: 23  PSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKE 82
           PSF  V +T++      + T   + ++ L  V    + +        P P + WLK+G  
Sbjct: 317 PSFKSV-NTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG-- 373

Query: 83  FKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVERSP 138
                +   Y  R   +SLI++ V   D GNYT ++     N + ++  T  ++V  +  
Sbjct: 374 LPATEKSARYLTRG--YSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIY 431

Query: 139 HRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKH 178
            + +  +  P  A   +G      C  Y   QP I+W  H
Sbjct: 432 EKAV--SSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWH 469



 Score = 34.3 bits (77), Expect = 0.41
 Identities = 47/179 (26%), Positives = 75/179 (41%), Gaps = 37/179 (20%)

Query: 101 LIMESVVPSDKGNYTCVVEN--EYGSINHTYHLD----VVERSPHRPILQAGLPANASTV 154
           L ++ +   DKG YTC V +   + S+N + H+     +  +   + +L+        TV
Sbjct: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE--------TV 347

Query: 155 VGG-DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLY 213
            G        KV +   P + W+K           DGLP  +  K+A   T       L 
Sbjct: 348 AGKRSYRLSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYS---LI 391

Query: 214 IRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL---PAPGREKEITASPDYLEIAIYCIG 269
           I++VT EDAG YT L        F +   T++        EK +++ PD    A+Y +G
Sbjct: 392 IKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPD---PALYPLG 447


>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
           [Homo sapiens]
          Length = 300

 Score =  289 bits (739), Expect = 7e-78
 Identities = 140/221 (63%), Positives = 161/221 (72%), Gaps = 23/221 (10%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVE-----------------------DTTLEPEG 37
           M SW   +   V+  ATL  ARPS +L E                       D T     
Sbjct: 1   MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60

Query: 38  APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
           APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR  
Sbjct: 61  APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120

Query: 98  HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
            WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN +  +G 
Sbjct: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 180

Query: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK 198
           +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK
Sbjct: 181 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 221



 Score = 30.8 bits (68), Expect = 4.5
 Identities = 22/87 (25%), Positives = 36/87 (41%), Gaps = 12/87 (13%)

Query: 159 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 218
           V+F C       P ++W+K    NG ++ PD        +  G         ++ + +V 
Sbjct: 83  VKFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRYATWSII-MDSVV 130

Query: 219 FEDAGEYTCLAGNSIGISFHSAWLTVL 245
             D G YTC+  N  G   H+  L V+
Sbjct: 131 PSDKGNYTCIVENEYGSINHTYQLDVV 157


>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
           homolog isoform 2 precursor [Homo sapiens]
          Length = 972

 Score =  289 bits (739), Expect = 7e-78
 Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)

Query: 352 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 411
           +LP D KWEFPR++L+ GK LG G FG+VV A A G+ K     A+TVAVKMLK  A   
Sbjct: 571 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 628

Query: 412 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 466
           +   L+SE++++  +G H NI+NLLGACT  GP  VI EY   G+L  +LR +R      
Sbjct: 629 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 688

Query: 467 ---------------------------------PGMEY----------SYDINRVPEEQM 483
                                            PG+ Y          S  I    E  +
Sbjct: 689 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 748

Query: 484 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 531
           T             +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T   + KI DFG
Sbjct: 749 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 808

Query: 532 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 591
           LARDI N   Y    N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 809 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 868

Query: 592 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 650
           +PV+ + +K++KEG RM  P +   E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 869 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 928

Query: 651 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 686
           N  Y +L+       +P+  +S       S+ SS    +   D
Sbjct: 929 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 971



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 32/136 (23%), Positives = 61/136 (44%), Gaps = 15/136 (11%)

Query: 100 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHR--PILQAGLPANASTVVGG 157
           +L + S   +D G + C   N +GS N T  L+VV++      P++   +  N     G 
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVND----GE 329

Query: 158 DVEFVCKVYSDAQP-HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 216
           +V+ + +  +  +P H QWI ++ +  +    D   Y K    + +    + +  L++  
Sbjct: 330 NVDLIVEYEAFPKPEHQQWI-YMNRTFTDKWED---YPKSENESNI----RYVSELHLTR 381

Query: 217 VTFEDAGEYTCLAGNS 232
           +   + G YT L  NS
Sbjct: 382 LKGTEGGTYTFLVSNS 397


>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
           homolog isoform 1 precursor [Homo sapiens]
          Length = 976

 Score =  289 bits (739), Expect = 7e-78
 Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)

Query: 352 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 411
           +LP D KWEFPR++L+ GK LG G FG+VV A A G+ K     A+TVAVKMLK  A   
Sbjct: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632

Query: 412 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 466
           +   L+SE++++  +G H NI+NLLGACT  GP  VI EY   G+L  +LR +R      
Sbjct: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692

Query: 467 ---------------------------------PGMEY----------SYDINRVPEEQM 483
                                            PG+ Y          S  I    E  +
Sbjct: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752

Query: 484 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 531
           T             +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T   + KI DFG
Sbjct: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812

Query: 532 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 591
           LARDI N   Y    N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872

Query: 592 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 650
           +PV+ + +K++KEG RM  P +   E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932

Query: 651 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 686
           N  Y +L+       +P+  +S       S+ SS    +   D
Sbjct: 933 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 975



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 32/136 (23%), Positives = 61/136 (44%), Gaps = 15/136 (11%)

Query: 100 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHR--PILQAGLPANASTVVGG 157
           +L + S   +D G + C   N +GS N T  L+VV++      P++   +  N     G 
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVND----GE 329

Query: 158 DVEFVCKVYSDAQP-HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 216
           +V+ + +  +  +P H QWI ++ +  +    D   Y K    + +    + +  L++  
Sbjct: 330 NVDLIVEYEAFPKPEHQQWI-YMNRTFTDKWED---YPKSENESNI----RYVSELHLTR 381

Query: 217 VTFEDAGEYTCLAGNS 232
           +   + G YT L  NS
Sbjct: 382 LKGTEGGTYTFLVSNS 397


>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
           [Homo sapiens]
          Length = 302

 Score =  287 bits (734), Expect = 3e-77
 Identities = 139/223 (62%), Positives = 160/223 (71%), Gaps = 25/223 (11%)

Query: 1   MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEG----------------------- 37
           M SW   +   V+  ATL  ARPS +L E   L                           
Sbjct: 1   MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60

Query: 38  --APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVR 95
             APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR
Sbjct: 61  PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120

Query: 96  NQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV 155
              WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN +  +
Sbjct: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 180

Query: 156 GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK 198
           G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK
Sbjct: 181 GSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 223



 Score = 30.8 bits (68), Expect = 4.5
 Identities = 22/87 (25%), Positives = 36/87 (41%), Gaps = 12/87 (13%)

Query: 159 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 218
           V+F C       P ++W+K    NG ++ PD        +  G         ++ + +V 
Sbjct: 85  VKFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRYATWSII-MDSVV 132

Query: 219 FEDAGEYTCLAGNSIGISFHSAWLTVL 245
             D G YTC+  N  G   H+  L V+
Sbjct: 133 PSDKGNYTCIVENEYGSINHTYQLDVV 159


>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
            domains 1 [Homo sapiens]
          Length = 1138

 Score =  244 bits (624), Expect = 2e-64
 Identities = 134/295 (45%), Positives = 186/295 (63%), Gaps = 10/295 (3%)

Query: 364  DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 423
            + +T    +GEG FGQV+ A    I KD  K  +  A+KMLK+ A+E D  D   E+E++
Sbjct: 837  EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891

Query: 424  KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 483
              +G H NIINLLGAC   G LY+ +EYA  GNL ++LR  R    + ++         +
Sbjct: 892  CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951

Query: 484  TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 543
            + + L+      A GM+YL+ ++ IHRDLAARNVLV EN   KIADFGL+R     + Y 
Sbjct: 952  SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008

Query: 544  KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 603
            K T GRLPV+WMA E+L   VYT +SDVWSFGVL+WEI +LGG+PY G+   EL++ L +
Sbjct: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068

Query: 604  GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLS 658
            G+RM++P NC +E+Y +MR CW   P +RP F Q+   L R+  L   + Y+++S
Sbjct: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMS 1121


>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
          Length = 1124

 Score =  244 bits (623), Expect = 2e-64
 Identities = 128/275 (46%), Positives = 182/275 (66%), Gaps = 8/275 (2%)

Query: 372  LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 431
            +GEG FGQV+ A    I KD  +  +  A+K +K+ A++ D  D   E+E++  +G H N
Sbjct: 830  IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884

Query: 432  IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 491
            IINLLGAC   G LY+ +EYA  GNL ++LR  R    + ++ I       ++ + L+  
Sbjct: 885  IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944

Query: 492  TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 551
               +ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R     + Y K T GRLP
Sbjct: 945  AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001

Query: 552  VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 611
            V+WMA E+L   VYT  SDVWS+GVL+WEI +LGG+PY G+   EL++ L +G+R++KP 
Sbjct: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061

Query: 612  NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 646
            NC +E+Y +MR CW   P +RP+F Q++  L+R+L
Sbjct: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,980,237
Number of Sequences: 37866
Number of extensions: 1362867
Number of successful extensions: 9259
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 682
Number of HSP's successfully gapped in prelim test: 365
Number of HSP's that attempted gapping in prelim test: 3859
Number of HSP's gapped (non-prelim): 2901
length of query: 706
length of database: 18,247,518
effective HSP length: 109
effective length of query: 597
effective length of database: 14,120,124
effective search space: 8429714028
effective search space used: 8429714028
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press