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Search of human proteins with 222144235
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
(707 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 1449 0.0
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 1327 0.0
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 1321 0.0
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 1320 0.0
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 1313 0.0
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 1262 0.0
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 1257 0.0
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 1068 0.0
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 1067 0.0
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 1055 0.0
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 1054 0.0
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 979 0.0
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 955 0.0
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 923 0.0
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 901 0.0
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 847 0.0
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 847 0.0
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 828 0.0
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 755 0.0
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 596 e-170
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 328 1e-89
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 324 2e-88
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 324 2e-88
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 321 2e-87
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur... 310 2e-84
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur... 310 4e-84
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 285 8e-77
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 285 8e-77
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 247 3e-65
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 244 2e-64
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 1449 bits (3751), Expect = 0.0
Identities = 707/707 (100%), Positives = 707/707 (100%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 120
NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV
Sbjct: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 120
Query: 121 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180
RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV
Sbjct: 121 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180
Query: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 240
VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI
Sbjct: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 240
Query: 241 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 300
RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA
Sbjct: 241 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 300
Query: 301 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 360
CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT
Sbjct: 301 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 360
Query: 361 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 420
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK
Sbjct: 361 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 420
Query: 421 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 480
EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
Sbjct: 421 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 480
Query: 481 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 540
GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
Sbjct: 481 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 540
Query: 541 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 600
RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF
Sbjct: 541 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 600
Query: 601 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 660
GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT
Sbjct: 601 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 660
Query: 661 FKQLVEDLDRILTLTTNEEEKKVSGAVDCHKPPCNPSHLPCVLAVDQ 707
FKQLVEDLDRILTLTTNEEEKKVSGAVDCHKPPCNPSHLPCVLAVDQ
Sbjct: 661 FKQLVEDLDRILTLTTNEEEKKVSGAVDCHKPPCNPSHLPCVLAVDQ 707
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 1327 bits (3434), Expect = 0.0
Identities = 654/681 (96%), Positives = 662/681 (97%), Gaps = 5/681 (0%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 120
NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV
Sbjct: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 120
Query: 121 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180
RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV
Sbjct: 121 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180
Query: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 240
VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK +G+N+++ E+ L+
Sbjct: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALF- 239
Query: 241 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP---APGREKEITASPDYLEIAIYCIGVF 297
NVT DAGEY C N IG + SAWLTVLP APGREKEITASPDYLEIAIYCIGVF
Sbjct: 240 -NVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVF 298
Query: 298 LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 357
LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR
Sbjct: 299 LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 358
Query: 358 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 417
ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD
Sbjct: 359 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 418
Query: 418 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 477
KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY
Sbjct: 419 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 478
Query: 478 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 537
ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD
Sbjct: 479 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 538
Query: 538 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 597
LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV
Sbjct: 539 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 598
Query: 598 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 657
WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ
Sbjct: 599 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 658
Query: 658 RPTFKQLVEDLDRILTLTTNE 678
RPTFKQLVEDLDRILTLTTNE
Sbjct: 659 RPTFKQLVEDLDRILTLTTNE 679
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 1321 bits (3420), Expect = 0.0
Identities = 655/701 (93%), Positives = 660/701 (94%), Gaps = 26/701 (3%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE A
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGA---------------------- 38
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 120
PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV
Sbjct: 39 ----PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
Query: 121 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180
RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV
Sbjct: 95 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
Query: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 240
VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI
Sbjct: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
Query: 241 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 300
RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA
Sbjct: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 274
Query: 301 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 360
CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT
Sbjct: 275 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 334
Query: 361 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 420
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK
Sbjct: 335 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 394
Query: 421 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 480
EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
Sbjct: 395 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 454
Query: 481 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 540
GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
Sbjct: 455 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 514
Query: 541 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 600
RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF
Sbjct: 515 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 574
Query: 601 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 660
GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT
Sbjct: 575 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 634
Query: 661 FKQLVEDLDRILTLTTNEEEKKVSGAVDCHKPPCNPSHLPC 701
FKQLVEDLDRILTLTTNEE +S ++ + P + C
Sbjct: 635 FKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSC 675
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 1320 bits (3417), Expect = 0.0
Identities = 646/665 (97%), Positives = 651/665 (97%)
Query: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP
Sbjct: 126 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 185
Query: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH
Sbjct: 186 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 245
Query: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG
Sbjct: 246 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 305
Query: 217 LPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGR 276
LPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGR
Sbjct: 306 LPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGR 365
Query: 277 EKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLR 336
EKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLR
Sbjct: 366 EKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLR 425
Query: 337 RQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGK 396
RQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGK
Sbjct: 426 RQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGK 485
Query: 397 PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 456
PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK
Sbjct: 486 PLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 545
Query: 457 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVS 516
NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVS
Sbjct: 546 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVS 605
Query: 517 CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRL 576
CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRL
Sbjct: 606 CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRL 665
Query: 577 PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP 636
PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP
Sbjct: 666 PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP 725
Query: 637 ANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEEKKVSGAVDCHKPPCNP 696
ANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE +S ++ + P
Sbjct: 726 ANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPD 785
Query: 697 SHLPC 701
+ C
Sbjct: 786 TRSSC 790
Score = 82.0 bits (201), Expect = 2e-15
Identities = 77/299 (25%), Positives = 114/299 (38%), Gaps = 78/299 (26%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117
T + + ++ +++ RC + W K+G +R IG
Sbjct: 40 -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
Query: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161
Y L ++ P D G Y C S + ++V +
Sbjct: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Query: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212
R+P+ + + V+F C + P ++W+ KNG ++
Sbjct: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWL----KNGKEF 198
Query: 213 GPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 271
+ + G ++ L + +V D G YTC+ N G H+ L V+
Sbjct: 199 KQEH-------RIGGYKVRNQHWS-LIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 1313 bits (3398), Expect = 0.0
Identities = 653/701 (93%), Positives = 658/701 (93%), Gaps = 28/701 (3%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE A
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGA---------------------- 38
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 120
PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV
Sbjct: 39 ----PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKV 94
Query: 121 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 180
RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV
Sbjct: 95 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 154
Query: 181 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 240
VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI
Sbjct: 155 VGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYI 214
Query: 241 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 300
RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA
Sbjct: 215 RNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIA 274
Query: 301 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 360
CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV SAESSSSMNSNTPLVRITT
Sbjct: 275 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVRITT 332
Query: 361 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 420
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK
Sbjct: 333 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 392
Query: 421 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 480
EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
Sbjct: 393 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 452
Query: 481 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 540
GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
Sbjct: 453 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 512
Query: 541 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 600
RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF
Sbjct: 513 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 572
Query: 601 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 660
GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT
Sbjct: 573 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 632
Query: 661 FKQLVEDLDRILTLTTNEEEKKVSGAVDCHKPPCNPSHLPC 701
FKQLVEDLDRILTLTTNEE +S ++ + P + C
Sbjct: 633 FKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSC 673
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 1262 bits (3265), Expect = 0.0
Identities = 622/668 (93%), Positives = 635/668 (95%), Gaps = 5/668 (0%)
Query: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP
Sbjct: 126 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 185
Query: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH
Sbjct: 186 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 245
Query: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG
Sbjct: 246 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 305
Query: 217 LPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP---A 273
LPYLKVLK +G+N+++ E+ L+ NVT DAGEY C N IG + SAWLTVLP A
Sbjct: 306 LPYLKVLKHSGINSSNAEVLALF--NVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQA 363
Query: 274 PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 333
PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI
Sbjct: 364 PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 423
Query: 334 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 393
PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT
Sbjct: 424 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 483
Query: 394 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 453
LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG
Sbjct: 484 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 543
Query: 454 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 513
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD
Sbjct: 544 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 603
Query: 514 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 573
LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN
Sbjct: 604 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 663
Query: 574 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 633
GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM
Sbjct: 664 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 723
Query: 634 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEEKKVSGAVDCHKPP 693
DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE +S ++ + P
Sbjct: 724 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS 783
Query: 694 CNPSHLPC 701
+ C
Sbjct: 784 YPDTRSSC 791
Score = 82.0 bits (201), Expect = 2e-15
Identities = 77/299 (25%), Positives = 114/299 (38%), Gaps = 78/299 (26%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117
T + + ++ +++ RC + W K+G +R IG
Sbjct: 40 -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
Query: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161
Y L ++ P D G Y C S + ++V +
Sbjct: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Query: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212
R+P+ + + V+F C + P ++W+ KNG ++
Sbjct: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWL----KNGKEF 198
Query: 213 GPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 271
+ + G ++ L + +V D G YTC+ N G H+ L V+
Sbjct: 199 KQEH-------RIGGYKVRNQHWS-LIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 1257 bits (3253), Expect = 0.0
Identities = 618/645 (95%), Positives = 626/645 (97%), Gaps = 5/645 (0%)
Query: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP
Sbjct: 126 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 185
Query: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH
Sbjct: 186 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 245
Query: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG
Sbjct: 246 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 305
Query: 217 LPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP---A 273
LPYLKVLK +G+N+++ E+ L+ NVT DAGEY C N IG + SAWLTVLP A
Sbjct: 306 LPYLKVLKHSGINSSNAEVLALF--NVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQA 363
Query: 274 PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 333
PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI
Sbjct: 364 PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 423
Query: 334 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 393
PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT
Sbjct: 424 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 483
Query: 394 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 453
LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG
Sbjct: 484 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 543
Query: 454 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 513
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD
Sbjct: 544 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 603
Query: 514 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 573
LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN
Sbjct: 604 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 663
Query: 574 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 633
GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM
Sbjct: 664 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 723
Query: 634 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 678
DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE
Sbjct: 724 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
Score = 82.0 bits (201), Expect = 2e-15
Identities = 77/299 (25%), Positives = 114/299 (38%), Gaps = 78/299 (26%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117
T + + ++ +++ RC + W K+G +R IG
Sbjct: 40 -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
Query: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161
Y L ++ P D G Y C S + ++V +
Sbjct: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Query: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212
R+P+ + + V+F C + P ++W+ KNG ++
Sbjct: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWL----KNGKEF 198
Query: 213 GPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 271
+ + G ++ L + +V D G YTC+ N G H+ L V+
Sbjct: 199 KQEH-------RIGGYKVRNQHWS-LIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 1068 bits (2761), Expect = 0.0
Identities = 522/695 (75%), Positives = 589/695 (84%), Gaps = 11/695 (1%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
M SW + V+ ATL ARPS TL +DA+ S +D+DD D + E N
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPS------PTLPEQDALPSSEDDDDDDDSSSEEKETDN 54
Query: 61 NKR---APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGG 117
K APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGG
Sbjct: 55 TKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGG 114
Query: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANA 177
YKVR WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN
Sbjct: 115 YKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANK 174
Query: 178 STVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEV 237
+ +G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EV
Sbjct: 175 TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEV 234
Query: 238 LYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVF 297
L++RNV+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G F
Sbjct: 235 LHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAF 294
Query: 298 LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 357
LI+CMV +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR
Sbjct: 295 LISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR 354
Query: 358 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 417
+RLSS+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKD
Sbjct: 355 -PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD 412
Query: 418 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 477
KP VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY
Sbjct: 413 KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 472
Query: 478 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 537
ASKGNLREYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRD
Sbjct: 473 ASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRD 532
Query: 538 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 597
LAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDV
Sbjct: 533 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV 592
Query: 598 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 657
WSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQ
Sbjct: 593 WSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQ 652
Query: 658 RPTFKQLVEDLDRILTLTTNEEEKKVSGAVDCHKP 692
RPTFKQLVEDLDRI+ LT+N+E +S +D + P
Sbjct: 653 RPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSP 687
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 1067 bits (2759), Expect = 0.0
Identities = 522/697 (74%), Positives = 589/697 (84%), Gaps = 13/697 (1%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
M SW + V+ ATL ARPS TL +DA+ S +D+DD D + E N
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPS------PTLPEQDALPSSEDDDDDDDSSSEEKETDN 54
Query: 61 NKR-----APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRI 115
K APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRI
Sbjct: 55 TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRI 114
Query: 116 GGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPA 175
GGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPA
Sbjct: 115 GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPA 174
Query: 176 NASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEI 235
N + +G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+
Sbjct: 175 NKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM 234
Query: 236 EVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIG 295
EVL++RNV+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G
Sbjct: 235 EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTG 294
Query: 296 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPL 355
FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS L
Sbjct: 295 AFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLL 354
Query: 356 VRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 415
VR +RLSS+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+D
Sbjct: 355 VR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLD 412
Query: 416 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 475
KDKP VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIV
Sbjct: 413 KDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 472
Query: 476 EYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIH 535
EYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIH
Sbjct: 473 EYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIH 532
Query: 536 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 595
RDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQS
Sbjct: 533 RDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQS 592
Query: 596 DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVP 655
DVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVP
Sbjct: 593 DVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVP 652
Query: 656 SQRPTFKQLVEDLDRILTLTTNEEEKKVSGAVDCHKP 692
SQRPTFKQLVEDLDRI+ LT+N+E +S +D + P
Sbjct: 653 SQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSP 689
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 1055 bits (2727), Expect = 0.0
Identities = 512/673 (76%), Positives = 578/673 (85%), Gaps = 5/673 (0%)
Query: 23 PSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHA 79
PS S ++ DA+ S +D+DD D + E N K APYWT+ EKMEK+LHA
Sbjct: 106 PSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHA 165
Query: 80 VPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGN 139
VPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGN
Sbjct: 166 VPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGN 225
Query: 140 YTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHI 199
YTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHI
Sbjct: 226 YTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHI 285
Query: 200 QWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSI 259
QW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV+FEDAGEYTCLAGNSI
Sbjct: 286 QWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSI 345
Query: 260 GISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPD 319
G+S HSAWLTVL A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK D
Sbjct: 346 GLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSD 405
Query: 320 FSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYEL 379
F SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYEL
Sbjct: 406 FHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYEL 463
Query: 380 PEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL 439
PEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDL
Sbjct: 464 PEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 523
Query: 440 SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSY 499
SDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y
Sbjct: 524 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCY 583
Query: 500 DINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLA 559
+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLA
Sbjct: 584 NPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA 643
Query: 560 RDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP 619
RDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+P
Sbjct: 644 RDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP 703
Query: 620 VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE 679
VEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+E
Sbjct: 704 VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE 763
Query: 680 EKKVSGAVDCHKP 692
+S +D + P
Sbjct: 764 YLDLSMPLDQYSP 776
Score = 37.7 bits (86), Expect = 0.037
Identities = 61/301 (20%), Positives = 104/301 (34%), Gaps = 85/301 (28%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
M SW + V+ ATL ARPS +L E
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPE------------------------------- 29
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGY 118
+A W ++E L V + ++ RC + + ++ WL++G + + +R I G
Sbjct: 30 --QAQPWGAPVEVESFL--VHPGDLLQLRCRLRDD-VQSINWLRDGVQLAESNRTRITGE 84
Query: 119 KVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPH------------- 165
+V ++ VP+D G Y CV + GS + ++V + P
Sbjct: 85 EVE-------VQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSE 137
Query: 166 ---------RPILQAGLPANA------STVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGS 210
P+ + V+F C P ++W+ KNG
Sbjct: 138 EKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWL----KNGK 193
Query: 211 KYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTV 270
++ PD + G ++ + +V D G YTC+ N G H+ L V
Sbjct: 194 EFKPDH-------RIGGYKVRYATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDV 245
Query: 271 L 271
+
Sbjct: 246 V 246
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 1054 bits (2725), Expect = 0.0
Identities = 512/675 (75%), Positives = 578/675 (85%), Gaps = 7/675 (1%)
Query: 23 PSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRL 77
PS S ++ DA+ S +D+DD D + E N K APYWT+ EKMEK+L
Sbjct: 106 PSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKL 165
Query: 78 HAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDK 137
HAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDK
Sbjct: 166 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
Query: 138 GNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQP 197
GNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QP
Sbjct: 226 GNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQP 285
Query: 198 HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGN 257
HIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV+FEDAGEYTCLAGN
Sbjct: 286 HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGN 345
Query: 258 SIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKK 317
SIG+S HSAWLTVL A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK
Sbjct: 346 SIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKK 405
Query: 318 PDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEY 377
DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEY
Sbjct: 406 SDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEY 463
Query: 378 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 437
ELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEK
Sbjct: 464 ELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK 523
Query: 438 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY 497
DLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY
Sbjct: 524 DLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEY 583
Query: 498 SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 557
Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFG
Sbjct: 584 CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFG 643
Query: 558 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 617
LARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG
Sbjct: 644 LARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 703
Query: 618 IPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTN 677
+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N
Sbjct: 704 VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSN 763
Query: 678 EEEKKVSGAVDCHKP 692
+E +S +D + P
Sbjct: 764 QEYLDLSMPLDQYSP 778
Score = 38.1 bits (87), Expect = 0.028
Identities = 63/303 (20%), Positives = 105/303 (34%), Gaps = 87/303 (28%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
M SW + V+ ATL ARPS +L E
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPE------------------------------- 29
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGY 118
+A W ++E L V + ++ RC + + ++ WL++G + + +R I G
Sbjct: 30 --QAQPWGAPVEVESFL--VHPGDLLQLRCRLRDD-VQSINWLRDGVQLAESNRTRITGE 84
Query: 119 KVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPH------------- 165
+V ++ VP+D G Y CV + GS + ++V + P
Sbjct: 85 EVE-------VQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSE 137
Query: 166 -------RPILQAGLPANAS----------TVVGGDVEFVCKVYSDAQPHIQWIKHVEKN 208
+P P S V+F C P ++W+ KN
Sbjct: 138 EKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWL----KN 193
Query: 209 GSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWL 268
G ++ PD + G ++ + +V D G YTC+ N G H+ L
Sbjct: 194 GKEFKPDH-------RIGGYKVRYATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQL 245
Query: 269 TVL 271
V+
Sbjct: 246 DVV 248
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 979 bits (2530), Expect = 0.0
Identities = 486/660 (73%), Positives = 554/660 (83%), Gaps = 18/660 (2%)
Query: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
DA SSGDDED D AED + APYWT E+M+K+L AVPAANTV+FRCPA GNP
Sbjct: 127 DAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
Query: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY
Sbjct: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
Query: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG
Sbjct: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
Query: 217 LPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGR 276
PY+ VLK AG NTTDKE+EVL + NVTFEDAGEYTCLAGNSIG S HSAWL VLPA
Sbjct: 303 TPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPA--- 359
Query: 277 EKEITASPD----YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKR 332
E+E+ + + Y I Y +G FL +V V LCR+++ KK P VHK++ R
Sbjct: 360 EEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-R 416
Query: 333 IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL 392
PL+RQV S ES++SM+SNTPLVRI RLSS + P LA VSE ELP DPKWE R +L
Sbjct: 417 FPLKRQV--SLESNASMSSNTPLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARL 472
Query: 393 TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI 452
TLGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMI
Sbjct: 473 TLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMI 532
Query: 453 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK 512
GKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFK
Sbjct: 533 GKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFK 592
Query: 513 DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT 572
DLVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTT
Sbjct: 593 DLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTT 652
Query: 573 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR 632
NGRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHR
Sbjct: 653 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHR 712
Query: 633 MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEEKKVSGAVDCHKP 692
MDKPANCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR+LT+T+ +E +S + + P
Sbjct: 713 MDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSP 772
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 955 bits (2468), Expect = 0.0
Identities = 476/675 (70%), Positives = 541/675 (80%), Gaps = 44/675 (6%)
Query: 23 PSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRL 77
PS S ++ DA+ S +D+DD D + E N K APYWT+ EKMEK+L
Sbjct: 106 PSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKL 165
Query: 78 HAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDK 137
HAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDK
Sbjct: 166 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 225
Query: 138 GNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQP 197
GNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QP
Sbjct: 226 GNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQP 285
Query: 198 HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGN 257
HIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV+FEDAGEYTCLAGN
Sbjct: 286 HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGN 345
Query: 258 SIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKK 317
SIG+S HSAWLTVL A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK
Sbjct: 346 SIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKK 405
Query: 318 PDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEY 377
DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEY
Sbjct: 406 SDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEY 463
Query: 378 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 437
ELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEK
Sbjct: 464 ELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK 523
Query: 438 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY 497
DLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY
Sbjct: 524 DLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEY 583
Query: 498 SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 557
Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFG
Sbjct: 584 CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFG 643
Query: 558 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 617
LARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG
Sbjct: 644 LARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 703
Query: 618 IPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTN 677
+PVEEL FKQLVEDLDRI+ LT+N
Sbjct: 704 VPVEEL-------------------------------------FKQLVEDLDRIVALTSN 726
Query: 678 EEEKKVSGAVDCHKP 692
+E +S +D + P
Sbjct: 727 QEYLDLSMPLDQYSP 741
Score = 38.1 bits (87), Expect = 0.028
Identities = 63/303 (20%), Positives = 105/303 (34%), Gaps = 87/303 (28%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
M SW + V+ ATL ARPS +L E
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPE------------------------------- 29
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGY 118
+A W ++E L V + ++ RC + + ++ WL++G + + +R I G
Sbjct: 30 --QAQPWGAPVEVESFL--VHPGDLLQLRCRLRDD-VQSINWLRDGVQLAESNRTRITGE 84
Query: 119 KVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPH------------- 165
+V ++ VP+D G Y CV + GS + ++V + P
Sbjct: 85 EVE-------VQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSE 137
Query: 166 -------RPILQAGLPANAS----------TVVGGDVEFVCKVYSDAQPHIQWIKHVEKN 208
+P P S V+F C P ++W+ KN
Sbjct: 138 EKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWL----KN 193
Query: 209 GSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWL 268
G ++ PD + G ++ + +V D G YTC+ N G H+ L
Sbjct: 194 GKEFKPDH-------RIGGYKVRYATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQL 245
Query: 269 TVL 271
V+
Sbjct: 246 DVV 248
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 923 bits (2386), Expect = 0.0
Identities = 461/660 (69%), Positives = 538/660 (81%), Gaps = 16/660 (2%)
Query: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
DA SSGDDED D AED + APYWT E+M+K+L AVPAANTV+FRCPA GNP
Sbjct: 127 DAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
Query: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY
Sbjct: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
Query: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG
Sbjct: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
Query: 217 LPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGR 276
PY+ VLK+ + + ++ L + NV+ D GEY C A N IG++ + WL+V
Sbjct: 303 TPYVTVLKSWISESVEADVR-LRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAA 361
Query: 277 EKEITASPD----YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKR 332
E+E+ + + Y I Y +G FL +V V LCR+++ KK P VHK++ R
Sbjct: 362 EEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-R 418
Query: 333 IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL 392
PL+RQV S ES++SM+SNTPLVRI RLSS + P LA VSE ELP DPKWE R +L
Sbjct: 419 FPLKRQV--SLESNASMSSNTPLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARL 474
Query: 393 TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI 452
TLGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMI
Sbjct: 475 TLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMI 534
Query: 453 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK 512
GKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFK
Sbjct: 535 GKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFK 594
Query: 513 DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT 572
DLVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTT
Sbjct: 595 DLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTT 654
Query: 573 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR 632
NGRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHR
Sbjct: 655 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHR 714
Query: 633 MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEEKKVSGAVDCHKP 692
MDKPANCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR+LT+T+ +E +S + + P
Sbjct: 715 MDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSP 774
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 901 bits (2328), Expect = 0.0
Identities = 486/729 (66%), Positives = 530/729 (72%), Gaps = 79/729 (10%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117
T + + ++ +++ RC + W K+G +R IG
Sbjct: 40 -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
Query: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161
Y L ++ P D G Y C S + ++V +
Sbjct: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Query: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212
R+P+ + + V+F C + P ++W+K NG ++
Sbjct: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
Query: 213 GPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP 272
+ + G ++ ++ + +V D G YTC+ N G H+ L V+
Sbjct: 199 KQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVV- 249
Query: 273 APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKR 332
APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKR
Sbjct: 250 APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKR 309
Query: 333 IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL 392
IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL
Sbjct: 310 IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL 369
Query: 393 TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI 452
TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI
Sbjct: 370 TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI 429
Query: 453 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK 512
GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK
Sbjct: 430 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK 489
Query: 513 DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT 572
DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT
Sbjct: 490 DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT 549
Query: 573 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR 632
NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR
Sbjct: 550 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR 609
Query: 633 MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEEKKVSGAVDCHKP 692
MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE +S ++ + P
Sbjct: 610 MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSP 669
Query: 693 PCNPSHLPC 701
+ C
Sbjct: 670 SYPDTRSSC 678
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 847 bits (2187), Expect = 0.0
Identities = 427/679 (62%), Positives = 528/679 (77%), Gaps = 27/679 (3%)
Query: 5 GRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRA 64
GR++CL AR S ++++ TL D+++S +D++D D + +S ++A
Sbjct: 97 GRYLCL----------ARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQA 146
Query: 65 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 124
PYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++R+QH
Sbjct: 147 PYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQH 206
Query: 125 WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 184
WSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + VVG D
Sbjct: 207 WSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSD 266
Query: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 244
VE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK A +N++ E+EVLY+RNV+
Sbjct: 267 VELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYLRNVS 324
Query: 245 FEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEIT---ASPD--YLEIAIYCIGVFLI 299
EDAGEYTCLAGNSIG+S+ SAWLTVLP E++ T A+P+ Y +I +Y G +
Sbjct: 325 AEDAGEYTCLAGNSIGLSYQSAWLTVLP----EEDPTWTAAAPEARYTDIILYASGSLAL 380
Query: 300 ACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 359
A +++ L R + + PA + R PL RQ S ES SS S++ LVR
Sbjct: 381 AVLLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQF--SLESGSSGKSSSSLVR-G 435
Query: 360 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 419
RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D +P
Sbjct: 436 VRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARP 494
Query: 420 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 479
+A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+
Sbjct: 495 DQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAA 554
Query: 480 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 539
KGNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIHRDLA
Sbjct: 555 KGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLA 614
Query: 540 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 599
ARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDVWS
Sbjct: 615 ARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWS 674
Query: 600 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 659
FG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRP
Sbjct: 675 FGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRP 734
Query: 660 TFKQLVEDLDRILTLTTNE 678
TFKQLVE LD++L + E
Sbjct: 735 TFKQLVEALDKVLLAVSEE 753
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 847 bits (2187), Expect = 0.0
Identities = 427/679 (62%), Positives = 528/679 (77%), Gaps = 27/679 (3%)
Query: 5 GRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRA 64
GR++CL AR S ++++ TL D+++S +D++D D + +S ++A
Sbjct: 97 GRYLCL----------ARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQA 146
Query: 65 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 124
PYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++R+QH
Sbjct: 147 PYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQH 206
Query: 125 WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 184
WSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + VVG D
Sbjct: 207 WSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSD 266
Query: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 244
VE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK A +N++ E+EVLY+RNV+
Sbjct: 267 VELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYLRNVS 324
Query: 245 FEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEIT---ASPD--YLEIAIYCIGVFLI 299
EDAGEYTCLAGNSIG+S+ SAWLTVLP E++ T A+P+ Y +I +Y G +
Sbjct: 325 AEDAGEYTCLAGNSIGLSYQSAWLTVLP----EEDPTWTAAAPEARYTDIILYASGSLAL 380
Query: 300 ACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 359
A +++ L R + + PA + R PL RQ S ES SS S++ LVR
Sbjct: 381 AVLLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQF--SLESGSSGKSSSSLVR-G 435
Query: 360 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 419
RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D +P
Sbjct: 436 VRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARP 494
Query: 420 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 479
+A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+
Sbjct: 495 DQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAA 554
Query: 480 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 539
KGNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIHRDLA
Sbjct: 555 KGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLA 614
Query: 540 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 599
ARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDVWS
Sbjct: 615 ARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWS 674
Query: 600 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 659
FG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRP
Sbjct: 675 FGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRP 734
Query: 660 TFKQLVEDLDRILTLTTNE 678
TFKQLVE LD++L + E
Sbjct: 735 TFKQLVEALDKVLLAVSEE 753
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 828 bits (2139), Expect = 0.0
Identities = 418/674 (62%), Positives = 507/674 (75%), Gaps = 57/674 (8%)
Query: 5 GRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKRA 64
GR++CL AR S ++++ TL D+++S +D++D D + +S ++A
Sbjct: 97 GRYLCL----------ARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQA 146
Query: 65 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 124
PYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F E+RIGG ++R+QH
Sbjct: 147 PYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQH 206
Query: 125 WSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGD 184
WSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQAGLPAN + VVG D
Sbjct: 207 WSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSD 266
Query: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 244
VE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK A +N++ E+EVLY+RNV+
Sbjct: 267 VELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS--EVEVLYLRNVS 324
Query: 245 FEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVV 304
EDAGEYTCLAGNSIG+S+ SAWLTVLP GR +T D L A
Sbjct: 325 AEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPHLTC--DSLTPA-------------- 368
Query: 305 TVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSS 364
TK P S ES SS S++ LVR RLSS
Sbjct: 369 --------GRTKSPTLQ-------------------FSLESGSSGKSSSSLVR-GVRLSS 400
Query: 365 TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVT 424
+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV AEA G+D +P +A T
Sbjct: 401 SGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQAST 459
Query: 425 VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 484
VAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+GPLYVIVE A+KGNLR
Sbjct: 460 VAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLR 519
Query: 485 EYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVL 544
E+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL S+KCIHRDLAARNVL
Sbjct: 520 EFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVL 579
Query: 545 VTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLM 604
VTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDRVYTHQSDVWSFG+L+
Sbjct: 580 VTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILL 639
Query: 605 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQL 664
WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+CWHA PSQRPTFKQL
Sbjct: 640 WEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQL 699
Query: 665 VEDLDRILTLTTNE 678
VE LD++L + E
Sbjct: 700 VEALDKVLLAVSEE 713
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 755 bits (1949), Expect = 0.0
Identities = 428/737 (58%), Positives = 483/737 (65%), Gaps = 99/737 (13%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
Query: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117
T + + ++ +++ RC + W K+G +R IG
Sbjct: 40 -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
Query: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161
Y L ++ P D G Y C S + ++V +
Sbjct: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Query: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212
R+P+ + + V+F C + P ++W+K NG ++
Sbjct: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKEF 198
Query: 213 GPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP 272
+ + G ++ ++ + +V D G YTC+ N G H+ L V+
Sbjct: 199 KQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVVE 250
Query: 273 APGREKEITASPDYLEIAIYCIGVFLIACMVV---TVILCRMKNTTKKPDFSSQPAVHKL 329
+ A G+ A VV +C++ + + P V K
Sbjct: 251 RSPHRPILQA------------GLPANASTVVGGDVEFVCKVYSDAQ-PHIQWIKHVEKN 297
Query: 330 TKR-----IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK 384
+ +P + + VSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK
Sbjct: 298 GSKYGPDGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK 357
Query: 385 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 444
WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS
Sbjct: 358 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 417
Query: 445 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRV 504
EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRV
Sbjct: 418 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRV 477
Query: 505 PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN 564
PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN
Sbjct: 478 PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN 537
Query: 565 IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 624
IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF
Sbjct: 538 IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 597
Query: 625 KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEEKKVS 684
KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE +S
Sbjct: 598 KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLS 657
Query: 685 GAVDCHKPPCNPSHLPC 701
++ + P + C
Sbjct: 658 QPLEQYSPSYPDTRSSC 674
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 596 bits (1536), Expect = e-170
Identities = 317/513 (61%), Positives = 372/513 (72%), Gaps = 29/513 (5%)
Query: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 244
V F C + P I W+K NG ++ + + G+ ++ L + +V
Sbjct: 172 VRFRCPAAGNPTPSISWLK----NGREFRGEH-------RIGGIKLRHQQWS-LVMESVV 219
Query: 245 FEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVV 304
D G YTC+ N G + L VL + A + A+ V C V
Sbjct: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEF-HCKVY 278
Query: 305 TVILCRMKNTTKKPDFSSQPAVHKLTKRI-----PLRRQVTVSAESSSSMNSNTPLVRIT 359
+ +P V ++ P + VS ES++SM+SNTPLVRI
Sbjct: 279 S---------DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIA 329
Query: 360 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 419
RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+
Sbjct: 330 -RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRA 387
Query: 420 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 479
+ VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+
Sbjct: 388 AKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAA 447
Query: 480 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 539
KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLA
Sbjct: 448 KGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 507
Query: 540 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 599
ARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS
Sbjct: 508 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 567
Query: 600 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 659
FGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRP
Sbjct: 568 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP 627
Query: 660 TFKQLVEDLDRILTLTTNEEEKKVSGAVDCHKP 692
TFKQLVEDLDR+LT+T+ +E +S + + P
Sbjct: 628 TFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSP 660
Score = 286 bits (733), Expect = 3e-77
Identities = 135/190 (71%), Positives = 156/190 (82%), Gaps = 4/190 (2%)
Query: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
DA SSGDDED D AED + APYWT E+M+K+L AVPAANTV+FRCPA GNP
Sbjct: 127 DAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
Query: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY
Sbjct: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
Query: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG
Sbjct: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
Query: 217 LPYLKVLKAA 226
PY+ VLK +
Sbjct: 303 TPYVTVLKVS 312
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 328 bits (841), Expect = 1e-89
Identities = 237/615 (38%), Positives = 310/615 (50%), Gaps = 126/615 (20%)
Query: 127 LIMESVVPS--DKGNYTCVVENEYGSINHTY--HLDVVERSPHRPILQAGLPANASTVVG 182
LIME S D+G+Y C+ ++ H L V+ER P + L N +T +G
Sbjct: 625 LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIG 681
Query: 183 GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 242
+E C + P I W K N + G+ VLK N T IR
Sbjct: 682 ESIEVSCTASGNPPPQIMWFKD---NETLVEDSGI----VLKDGNRNLT--------IRR 726
Query: 243 VTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACM 302
V ED G YTC A + +G + A+ + A + LEI I +G +IA
Sbjct: 727 VRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTN--------LEIIIL-VGTAVIAMF 777
Query: 303 --VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 360
++ VI+ R TV + + T
Sbjct: 778 FWLLLVIILR-----------------------------TVKRANGGELK--------TG 800
Query: 361 RLSSTADTPMLAGVSEYE-LPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 418
LS D L E LP D KWEFPRD+L LGKPLG G FGQV+ A+A GIDK
Sbjct: 801 YLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTA 860
Query: 419 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEY 477
TVAVKMLK+ AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE+
Sbjct: 861 TCR--TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEF 918
Query: 478 ASKGNLREYLRARRPPGMEYS-----------------YDINR----------------- 503
GNL YLR++R + Y D+ R
Sbjct: 919 CKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFV 978
Query: 504 -------VPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE 547
V EE+ +T + L+ ++Q+A+GME+LAS+KCIHRDLAARN+L++E
Sbjct: 979 EEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE 1038
Query: 548 NNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI 607
NV+KI DFGLARDI Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVL+WEI
Sbjct: 1039 KNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEI 1098
Query: 608 FTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVE 666
F+LG SPYPG+ ++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LVE
Sbjct: 1099 FSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVE 1158
Query: 667 DLDRILTLTTNEEEK 681
L +L ++ K
Sbjct: 1159 HLGNLLQANAQQDGK 1173
Score = 41.6 bits (96), Expect = 0.003
Identities = 35/124 (28%), Positives = 53/124 (42%), Gaps = 9/124 (7%)
Query: 87 KFRCPAG--GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV 144
+ R PA G P P ++W KNG + H I + H IME V D GNYT ++
Sbjct: 347 RVRIPAKYLGYPPPEIKWYKNGIPLESNHTI-----KAGHVLTIME-VSERDTGNYTVIL 400
Query: 145 ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQP-HIQWIK 203
N ++ + +V P + ++ + S G C VY+ P HI W
Sbjct: 401 TNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYW 460
Query: 204 HVEK 207
+E+
Sbjct: 461 QLEE 464
Score = 36.2 bits (82), Expect = 0.11
Identities = 19/75 (25%), Positives = 38/75 (50%), Gaps = 5/75 (6%)
Query: 68 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 127
T T +E + ++ +++ C A GNP P + W K+ + ++ G +++ + +L
Sbjct: 668 TITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNL 722
Query: 128 IMESVVPSDKGNYTC 142
+ V D+G YTC
Sbjct: 723 TIRRVRKEDEGLYTC 737
Score = 35.8 bits (81), Expect = 0.14
Identities = 35/136 (25%), Positives = 54/136 (39%), Gaps = 24/136 (17%)
Query: 126 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ--AGLPANASTVVGG 183
+L ++ V SD+G YTC + + ++ + V E+ P + +G+ + VG
Sbjct: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
Query: 184 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 243
V K P I+W K+ G+P N T K VL I V
Sbjct: 347 RVRIPAKYLGYPPPEIKWYKN-----------GIPLES-------NHTIKAGHVLTIMEV 388
Query: 244 TFEDAGEYTCLAGNSI 259
+ D G YT + N I
Sbjct: 389 SERDTGNYTVILTNPI 404
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 324 bits (830), Expect = 2e-88
Identities = 170/344 (49%), Positives = 224/344 (65%), Gaps = 20/344 (5%)
Query: 345 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 397
SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK
Sbjct: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
Query: 398 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 456
LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H
Sbjct: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
Query: 457 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 508
++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E
Sbjct: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
Query: 509 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 568
+T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y
Sbjct: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
Query: 569 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 628
K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
Query: 629 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 672
GHRM++P NC+ E+Y +M CW P +RP F + +DL++++
Sbjct: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 324 bits (830), Expect = 2e-88
Identities = 170/344 (49%), Positives = 224/344 (65%), Gaps = 20/344 (5%)
Query: 345 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 397
SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK
Sbjct: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
Query: 398 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 456
LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H
Sbjct: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
Query: 457 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 508
++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E
Sbjct: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
Query: 509 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 568
+T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y
Sbjct: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
Query: 569 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 628
K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
Query: 629 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 672
GHRM++P NC+ E+Y +M CW P +RP F + +DL++++
Sbjct: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 321 bits (822), Expect = 2e-87
Identities = 217/613 (35%), Positives = 307/613 (50%), Gaps = 122/613 (19%)
Query: 126 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 185
+L + +V D G Y C N Y ++ R P L L ++ + +
Sbjct: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISSST 678
Query: 186 EFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTF 245
C +P I W K+ K + G ++ G +T L+I VT
Sbjct: 679 TLDCHANGVPEPQITWFKNNHKIQQEPG--------IILGPGSST-------LFIERVTE 723
Query: 246 EDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVT 305
ED G Y C A N G SA+LTV + ++ + + + C+ L +++T
Sbjct: 724 EDEGVYHCKATNQKGSVESSAYLTVQGTSDK-----SNLELITLTCTCVAATLF-WLLLT 777
Query: 306 VILCRMKNTTK--KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLS 363
+ + +MK ++ K D+ S + +PL Q
Sbjct: 778 LFIRKMKRSSSEIKTDYLS---IIMDPDEVPLDEQCE----------------------- 811
Query: 364 STADTPMLAGVSEYELPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 422
LP D KWEF R++L LGK LG G FG+VV A A GI K
Sbjct: 812 --------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR- 856
Query: 423 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKG 481
TVAVKMLK+ AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY G
Sbjct: 857 -TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYG 915
Query: 482 NLREYLRARRP--------------------PGMEYSY---------------------- 499
NL YL+++R PG+E
Sbjct: 916 NLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDK 975
Query: 500 DINRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 550
++ V EE+ +T +DL+S ++Q+ARGME+L+S+KCIHRDLAARN+L++ENNV
Sbjct: 976 SLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNV 1035
Query: 551 MKIADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 609
+KI DFGLARDI N DY +K RLP+KWMAPE++FD++Y+ +SDVWS+GVL+WEIF+
Sbjct: 1036 VKICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFS 1094
Query: 610 LGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 668
LGGSPYPG+ ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE L
Sbjct: 1095 LGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL 1154
Query: 669 DRILTLTTNEEEK 681
+L ++ K
Sbjct: 1155 GDLLQANVQQDGK 1167
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 3/82 (3%)
Query: 78 HAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDK 137
H V +++ C A G P P + W KN + +QE G + +L +E V D+
Sbjct: 670 HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGPGSSTLFIERVTEEDE 726
Query: 138 GNYTCVVENEYGSINHTYHLDV 159
G Y C N+ GS+ + +L V
Sbjct: 727 GVYHCKATNQKGSVESSAYLTV 748
Score = 40.4 bits (93), Expect = 0.006
Identities = 33/141 (23%), Positives = 57/141 (40%), Gaps = 10/141 (7%)
Query: 68 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 127
T + ++ L V + + P P + WLK+G + Y R +SL
Sbjct: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRG--YSL 390
Query: 128 IMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 183
I++ V D GNYT ++ N + ++ T ++V + + + + P A +G
Sbjct: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
Query: 184 DVEFVCKVYSDAQPHIQWIKH 204
C Y QP I+W H
Sbjct: 449 RQILTCTAYGIPQPTIKWFWH 469
Score = 34.3 bits (77), Expect = 0.41
Identities = 47/179 (26%), Positives = 75/179 (41%), Gaps = 37/179 (20%)
Query: 127 LIMESVVPSDKGNYTCVVEN--EYGSINHTYHLD----VVERSPHRPILQAGLPANASTV 180
L ++ + DKG YTC V + + S+N + H+ + + + +L+ TV
Sbjct: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE--------TV 347
Query: 181 VGG-DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLY 239
G KV + P + W+K DGLP + K+A T L
Sbjct: 348 AGKRSYRLSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYS---LI 391
Query: 240 IRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL---PAPGREKEITASPDYLEIAIYCIG 295
I++VT EDAG YT L F + T++ EK +++ PD A+Y +G
Sbjct: 392 IKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPD---PALYPLG 447
>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
[Homo sapiens]
Length = 300
Score = 310 bits (795), Expect = 2e-84
Identities = 148/227 (65%), Positives = 173/227 (76%), Gaps = 9/227 (3%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
M SW + V+ ATL ARPS TL +DA+ S +D+DD D + E N
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPS------PTLPEQDALPSSEDDDDDDDSSSEEKETDN 54
Query: 61 NKR---APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGG 117
K APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGG
Sbjct: 55 TKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGG 114
Query: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANA 177
YKVR WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN
Sbjct: 115 YKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANK 174
Query: 178 STVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK 224
+ +G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK
Sbjct: 175 TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 221
Score = 30.8 bits (68), Expect = 4.5
Identities = 22/87 (25%), Positives = 36/87 (41%), Gaps = 12/87 (13%)
Query: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 244
V+F C P ++W+K NG ++ PD + G ++ + +V
Sbjct: 83 VKFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRYATWSII-MDSVV 130
Query: 245 FEDAGEYTCLAGNSIGISFHSAWLTVL 271
D G YTC+ N G H+ L V+
Sbjct: 131 PSDKGNYTCIVENEYGSINHTYQLDVV 157
>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
[Homo sapiens]
Length = 302
Score = 310 bits (793), Expect = 4e-84
Identities = 148/229 (64%), Positives = 173/229 (75%), Gaps = 11/229 (4%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
M SW + V+ ATL ARPS TL +DA+ S +D+DD D + E N
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPS------PTLPEQDALPSSEDDDDDDDSSSEEKETDN 54
Query: 61 NKR-----APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRI 115
K APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRI
Sbjct: 55 TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRI 114
Query: 116 GGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPA 175
GGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPA
Sbjct: 115 GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPA 174
Query: 176 NASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK 224
N + +G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK
Sbjct: 175 NKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 223
Score = 30.8 bits (68), Expect = 4.5
Identities = 22/87 (25%), Positives = 36/87 (41%), Gaps = 12/87 (13%)
Query: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 244
V+F C P ++W+K NG ++ PD + G ++ + +V
Sbjct: 85 VKFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRYATWSII-MDSVV 132
Query: 245 FEDAGEYTCLAGNSIGISFHSAWLTVL 271
D G YTC+ N G H+ L V+
Sbjct: 133 PSDKGNYTCIVENEYGSINHTYQLDVV 159
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 285 bits (730), Expect = 8e-77
Identities = 156/361 (43%), Positives = 214/361 (59%), Gaps = 63/361 (17%)
Query: 378 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 437
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 571 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 628
Query: 438 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 492
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 629 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 688
Query: 493 ---------------------------------PGMEY----------SYDINRVPEEQM 509
PG+ Y S I E +
Sbjct: 689 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 748
Query: 510 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 557
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 749 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 808
Query: 558 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 617
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 809 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 868
Query: 618 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 676
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 869 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 928
Query: 677 N 677
N
Sbjct: 929 N 929
Score = 31.6 bits (70), Expect = 2.6
Identities = 32/136 (23%), Positives = 61/136 (44%), Gaps = 15/136 (11%)
Query: 126 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHR--PILQAGLPANASTVVGG 183
+L + S +D G + C N +GS N T L+VV++ P++ + N G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVND----GE 329
Query: 184 DVEFVCKVYSDAQP-HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 242
+V+ + + + +P H QWI ++ + + D Y K + + + + L++
Sbjct: 330 NVDLIVEYEAFPKPEHQQWI-YMNRTFTDKWED---YPKSENESNI----RYVSELHLTR 381
Query: 243 VTFEDAGEYTCLAGNS 258
+ + G YT L NS
Sbjct: 382 LKGTEGGTYTFLVSNS 397
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 285 bits (730), Expect = 8e-77
Identities = 156/361 (43%), Positives = 214/361 (59%), Gaps = 63/361 (17%)
Query: 378 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 437
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632
Query: 438 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 492
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
Query: 493 ---------------------------------PGMEY----------SYDINRVPEEQM 509
PG+ Y S I E +
Sbjct: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752
Query: 510 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 557
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812
Query: 558 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 617
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872
Query: 618 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 676
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932
Query: 677 N 677
N
Sbjct: 933 N 933
Score = 31.6 bits (70), Expect = 2.6
Identities = 32/136 (23%), Positives = 61/136 (44%), Gaps = 15/136 (11%)
Query: 126 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHR--PILQAGLPANASTVVGG 183
+L + S +D G + C N +GS N T L+VV++ P++ + N G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVND----GE 329
Query: 184 DVEFVCKVYSDAQP-HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 242
+V+ + + + +P H QWI ++ + + D Y K + + + + L++
Sbjct: 330 NVDLIVEYEAFPKPEHQQWI-YMNRTFTDKWED---YPKSENESNI----RYVSELHLTR 381
Query: 243 VTFEDAGEYTCLAGNS 258
+ + G YT L NS
Sbjct: 382 LKGTEGGTYTFLVSNS 397
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 247 bits (630), Expect = 3e-65
Identities = 133/297 (44%), Positives = 189/297 (63%), Gaps = 13/297 (4%)
Query: 398 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 457
+GEG FGQV+ A I KD + + A+K +K+ A++ D D E+E++ +G H N
Sbjct: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
Query: 458 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 517
IINLLGAC G LY+ +EYA GNL ++LR R + ++ I ++ + L+
Sbjct: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
Query: 518 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 577
+ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R + Y K T GRLP
Sbjct: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
Query: 578 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 637
V+WMA E+L VYT SDVWS+GVL+WEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
Query: 638 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT-----LTTNEEEKKVSGAVDC 689
NC +E+Y +MR CW P +RP+F Q++ L+R+L + T EK +DC
Sbjct: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDC 1118
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 244 bits (623), Expect = 2e-64
Identities = 132/283 (46%), Positives = 180/283 (63%), Gaps = 8/283 (2%)
Query: 390 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 449
+ +T +GEG FGQV+ A I KD K + A+KMLK+ A+E D D E+E++
Sbjct: 837 EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891
Query: 450 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 509
+G H NIINLLGAC G LY+ +EYA GNL ++LR R + ++ +
Sbjct: 892 CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951
Query: 510 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 569
+ + L+ A GM+YL+ ++ IHRDLAARNVLV EN KIADFGL+R + Y
Sbjct: 952 SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008
Query: 570 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 629
K T GRLPV+WMA E+L VYT +SDVWSFGVL+WEI +LGG+PY G+ EL++ L +
Sbjct: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068
Query: 630 GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 672
G+RM++P NC +E+Y +MR CW P +RP F Q+ L R+L
Sbjct: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRML 1111
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,753,631
Number of Sequences: 37866
Number of extensions: 1324725
Number of successful extensions: 9537
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 679
Number of HSP's successfully gapped in prelim test: 367
Number of HSP's that attempted gapping in prelim test: 4120
Number of HSP's gapped (non-prelim): 2921
length of query: 707
length of database: 18,247,518
effective HSP length: 109
effective length of query: 598
effective length of database: 14,120,124
effective search space: 8443834152
effective search space used: 8443834152
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.