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Search of human proteins with 222144231
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
(769 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 1569 0.0
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 1568 0.0
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 1508 0.0
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 1318 0.0
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 1257 0.0
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 1203 0.0
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 1195 0.0
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 1083 0.0
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 1083 0.0
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 1002 0.0
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 1001 0.0
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 984 0.0
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 972 0.0
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 962 0.0
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 842 0.0
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 837 0.0
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 837 0.0
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 813 0.0
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 699 0.0
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 598 e-171
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 324 2e-88
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 324 2e-88
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 323 5e-88
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 318 9e-87
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur... 296 4e-80
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur... 296 6e-80
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 289 8e-78
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 287 3e-77
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 244 2e-64
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 244 2e-64
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 1569 bits (4063), Expect = 0.0
Identities = 769/769 (100%), Positives = 769/769 (100%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
Sbjct: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
Query: 301 YGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK 360
YGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK
Sbjct: 301 YGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK 360
Query: 361 QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT 420
QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT
Sbjct: 361 QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT 420
Query: 421 KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 480
KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD
Sbjct: 421 KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 480
Query: 481 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 540
KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK
Sbjct: 481 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 540
Query: 541 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 600
MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT
Sbjct: 541 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 600
Query: 601 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 660
FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK
Sbjct: 601 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 660
Query: 661 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 720
TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG
Sbjct: 661 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 720
Query: 721 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI 769
HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI
Sbjct: 721 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI 769
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 1568 bits (4059), Expect = 0.0
Identities = 768/768 (100%), Positives = 768/768 (100%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
Sbjct: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
Query: 301 YGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK 360
YGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK
Sbjct: 301 YGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK 360
Query: 361 QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT 420
QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT
Sbjct: 361 QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT 420
Query: 421 KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 480
KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD
Sbjct: 421 KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 480
Query: 481 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 540
KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK
Sbjct: 481 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 540
Query: 541 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 600
MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT
Sbjct: 541 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 600
Query: 601 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 660
FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK
Sbjct: 601 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 660
Query: 661 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 720
TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG
Sbjct: 661 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 720
Query: 721 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE
Sbjct: 721 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 1508 bits (3905), Expect = 0.0
Identities = 743/770 (96%), Positives = 751/770 (97%), Gaps = 5/770 (0%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
Sbjct: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
Query: 301 YGPDGLPYLKVLKHSGINSSNAEVLALF--NVTEADAGEYICKVSNYIGQANQSAWLTVL 358
YGPDGLPYLKVLK +G+N+++ E+ L+ NVT DAGEY C N IG + SAWLTVL
Sbjct: 301 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 360
Query: 359 PKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK 418
P APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK
Sbjct: 361 P---APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK 417
Query: 419 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP 478
LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP
Sbjct: 418 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP 477
Query: 479 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 538
RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM
Sbjct: 478 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 537
Query: 539 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 598
MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ
Sbjct: 538 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 597
Query: 599 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 658
MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY
Sbjct: 598 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 657
Query: 659 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 718
KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK
Sbjct: 658 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 717
Query: 719 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE
Sbjct: 718 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 767
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 1318 bits (3411), Expect = 0.0
Identities = 644/644 (100%), Positives = 644/644 (100%)
Query: 126 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 185
DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP
Sbjct: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
Query: 186 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 245
MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH
Sbjct: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
Query: 246 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 305
LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG
Sbjct: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
Query: 306 LPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPG 365
LPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPG
Sbjct: 217 LPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPG 276
Query: 366 REKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPL 425
REKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPL
Sbjct: 277 REKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPL 336
Query: 426 RRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLG 485
RRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLG
Sbjct: 337 RRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLG 396
Query: 486 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 545
KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH
Sbjct: 397 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 456
Query: 546 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 605
KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV
Sbjct: 457 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 516
Query: 606 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 665
SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR
Sbjct: 517 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 576
Query: 666 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 725
LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK
Sbjct: 577 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 636
Query: 726 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI 769
PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI
Sbjct: 637 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI 680
Score = 82.8 bits (203), Expect = 1e-15
Identities = 78/300 (26%), Positives = 114/300 (38%), Gaps = 78/300 (26%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 40 -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
T + + ++ +++ RC + W K+G +R IG
Sbjct: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117
Query: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Y L ++ P D G Y C S + ++V +
Sbjct: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161
Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWL----KNGKEF 198
R+P+ + + V+F C + P ++W+ KNG ++
Sbjct: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212
Query: 199 KQEH-------RIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVER 251
+ + G N L + +V +D G Y C V N G N + L V+ +
Sbjct: 213 GPDGLPYLKVLKHSGINSSNAE-VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK 271
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 1257 bits (3253), Expect = 0.0
Identities = 618/645 (95%), Positives = 626/645 (97%), Gaps = 5/645 (0%)
Query: 126 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 185
DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP
Sbjct: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
Query: 186 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 245
MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH
Sbjct: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
Query: 246 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 305
LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG
Sbjct: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
Query: 306 LPYLKVLKHSGINSSNAEVLALF--NVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQA 363
LPYLKVLK +G+N+++ E+ L+ NVT DAGEY C N IG + SAWLTVLP A
Sbjct: 217 LPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLP---A 273
Query: 364 PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 423
PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI
Sbjct: 274 PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 333
Query: 424 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 483
PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT
Sbjct: 334 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 393
Query: 484 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 543
LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG
Sbjct: 394 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 453
Query: 544 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 603
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD
Sbjct: 454 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 513
Query: 604 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 663
LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN
Sbjct: 514 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 573
Query: 664 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 723
GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM
Sbjct: 574 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 633
Query: 724 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE
Sbjct: 634 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 678
Score = 82.0 bits (201), Expect = 2e-15
Identities = 77/299 (25%), Positives = 114/299 (38%), Gaps = 78/299 (26%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--------------------- 39
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE+
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 40 -------TKYQISQPEVYVAAPGESLEVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGE 90
T + + ++ +++ RC + W K+G +R IG
Sbjct: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGG 117
Query: 91 Y--------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAED 142
Y L ++ P D G Y C S + ++V +
Sbjct: 118 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVE---------------- 161
Query: 143 FVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWL----KNGKEF 198
R+P+ + + V+F C + P ++W+ KNG ++
Sbjct: 162 ---------RSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKY 212
Query: 199 KQEH-------RIGGYKVRNQHWS-LIMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
+ + G ++ L + +V D G YTC+ N G H+ L V+
Sbjct: 213 GPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 271
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 1203 bits (3113), Expect = 0.0
Identities = 591/618 (95%), Positives = 599/618 (96%), Gaps = 5/618 (0%)
Query: 153 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 212
APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ
Sbjct: 38 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
Query: 213 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 272
HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG
Sbjct: 98 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
Query: 273 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALF--NV 330
DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK +G+N+++ E+ L+ NV
Sbjct: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
Query: 331 TEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIA 390
T DAGEY C N IG + SAWLTVLP APGREKEITASPDYLEIAIYCIGVFLIA
Sbjct: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLP---APGREKEITASPDYLEIAIYCIGVFLIA 274
Query: 391 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 450
CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT
Sbjct: 275 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 334
Query: 451 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 510
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK
Sbjct: 335 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 394
Query: 511 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 570
EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
Sbjct: 395 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 454
Query: 571 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 630
GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
Sbjct: 455 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 514
Query: 631 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 690
RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF
Sbjct: 515 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 574
Query: 691 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 750
GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT
Sbjct: 575 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 634
Query: 751 FKQLVEDLDRILTLTTNE 768
FKQLVEDLDRILTLTTNE
Sbjct: 635 FKQLVEDLDRILTLTTNE 652
Score = 94.4 bits (233), Expect = 4e-19
Identities = 78/273 (28%), Positives = 114/273 (41%), Gaps = 52/273 (19%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE P T + + ++ ++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
Query: 59 EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108
+ RC + W K+G +R IG Y L ++ P D G Y C
Sbjct: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117
Query: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168
S + ++V + R+P+ + +
Sbjct: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152
Query: 169 VPAANTVKFRCPAGGNPMPTMRWL----KNGKEFKQEH-------RIGGYKVRNQHWS-L 216
V+F C + P ++W+ KNG ++ + + G ++ L
Sbjct: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
Query: 217 IMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
+ +V D G YTC+ N G H+ L V+
Sbjct: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 1195 bits (3091), Expect = 0.0
Identities = 589/618 (95%), Positives = 597/618 (96%), Gaps = 7/618 (1%)
Query: 153 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 212
APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ
Sbjct: 38 APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQ 97
Query: 213 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 272
HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG
Sbjct: 98 HWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 157
Query: 273 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALF--NV 330
DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLK +G+N+++ E+ L+ NV
Sbjct: 158 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNV 217
Query: 331 TEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIA 390
T DAGEY C N IG + SAWLTVLP APGREKEITASPDYLEIAIYCIGVFLIA
Sbjct: 218 TFEDAGEYTCLAGNSIGISFHSAWLTVLP---APGREKEITASPDYLEIAIYCIGVFLIA 274
Query: 391 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT 450
CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV SAESSSSMNSNTPLVRITT
Sbjct: 275 CMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPLVRITT 332
Query: 451 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 510
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK
Sbjct: 333 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 392
Query: 511 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 570
EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
Sbjct: 393 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 452
Query: 571 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 630
GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
Sbjct: 453 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 512
Query: 631 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 690
RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF
Sbjct: 513 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 572
Query: 691 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 750
GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT
Sbjct: 573 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 632
Query: 751 FKQLVEDLDRILTLTTNE 768
FKQLVEDLDRILTLTTNE
Sbjct: 633 FKQLVEDLDRILTLTTNE 650
Score = 94.4 bits (233), Expect = 4e-19
Identities = 78/273 (28%), Positives = 114/273 (41%), Gaps = 52/273 (19%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPP--TKYQISQPEVYVAAPGESL 58
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE P T + + ++ ++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
Query: 59 EVRCLL--KDAAVISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACT 108
+ RC + W K+G +R IG Y L ++ P D G Y C
Sbjct: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR---IGGYKVRNQHWSLIMESVVPSDKGNYTCV 117
Query: 109 ASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHA 168
S + ++V + R+P+ + +
Sbjct: 118 VENEYGSINHTYHLDVVE-------------------------RSPHRPILQAGLPANAS 152
Query: 169 VPAANTVKFRCPAGGNPMPTMRWL----KNGKEFKQEH-------RIGGYKVRNQHWS-L 216
V+F C + P ++W+ KNG ++ + + G ++ L
Sbjct: 153 TVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVL 212
Query: 217 IMESVVPSDKGNYTCVVENEYGSINHTYHLDVV 249
+ +V D G YTC+ N G H+ L V+
Sbjct: 213 YIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 1083 bits (2802), Expect = 0.0
Identities = 539/774 (69%), Positives = 626/774 (80%), Gaps = 18/774 (2%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
Query: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
Query: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVK 176
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVK
Sbjct: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVK 173
Query: 177 FRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
F+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENE
Sbjct: 174 FKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE 233
Query: 237 YGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEK 296
YGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E
Sbjct: 234 YGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV 293
Query: 297 NGSKYGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYIGQANQSAW 354
NGSK GPD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N IG ++ SAW
Sbjct: 294 NGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAW 353
Query: 355 LTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQP 414
LTVL +A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ
Sbjct: 354 LTVL---EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQM 410
Query: 415 AVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK 474
AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+
Sbjct: 411 AVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPR 468
Query: 475 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 534
WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+S
Sbjct: 469 WELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLIS 528
Query: 535 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRV 594
EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ +
Sbjct: 529 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHN 588
Query: 595 PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN 654
PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++
Sbjct: 589 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH 648
Query: 655 IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 714
IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELF
Sbjct: 649 IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 708
Query: 715 KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
KLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+
Sbjct: 709 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 762
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 1083 bits (2800), Expect = 0.0
Identities = 539/776 (69%), Positives = 626/776 (80%), Gaps = 20/776 (2%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
Query: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
Query: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANT 174
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA T
Sbjct: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKT 173
Query: 175 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 234
VKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VE
Sbjct: 174 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 233
Query: 235 NEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHV 294
NEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+
Sbjct: 234 NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 293
Query: 295 EKNGSKYGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYIGQANQS 352
E NGSK GPD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N IG ++ S
Sbjct: 294 EVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHS 353
Query: 353 AWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSS 412
AWLTVL +A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF S
Sbjct: 354 AWLTVL---EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHS 410
Query: 413 QPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPED 472
Q AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPED
Sbjct: 411 QMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPED 468
Query: 473 PKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDL 532
P+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL
Sbjct: 469 PRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL 528
Query: 533 VSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIN 592
+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ +
Sbjct: 529 ISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPS 588
Query: 593 RVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI 652
PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI
Sbjct: 589 HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI 648
Query: 653 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEE 712
++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEE
Sbjct: 649 HHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEE 708
Query: 713 LFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
LFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+
Sbjct: 709 LFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 764
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 1002 bits (2590), Expect = 0.0
Identities = 489/648 (75%), Positives = 554/648 (85%), Gaps = 10/648 (1%)
Query: 126 DAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVKF+CP+
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 90
Query: 183 GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH 242
G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSINH
Sbjct: 91 GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 150
Query: 243 TYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYG 302
TY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E NGSK G
Sbjct: 151 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 210
Query: 303 PDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK 360
PD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N IG ++ SAWLTVL
Sbjct: 211 PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL-- 268
Query: 361 QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLT 420
+A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL
Sbjct: 269 -EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLA 327
Query: 421 KRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRD 480
K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+WE PRD
Sbjct: 328 KSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRD 385
Query: 481 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 540
+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SEMEMMK
Sbjct: 386 RLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMK 445
Query: 541 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 600
MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++
Sbjct: 446 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLS 505
Query: 601 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 660
KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYYKK
Sbjct: 506 SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKK 565
Query: 661 TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG 720
TTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEG
Sbjct: 566 TTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEG 625
Query: 721 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
HRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+
Sbjct: 626 HRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 673
Score = 51.6 bits (122), Expect = 3e-06
Identities = 63/303 (20%), Positives = 106/303 (34%), Gaps = 75/303 (24%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEE---------------------PP 39
M SW + V+ ATL ARPS +L E L E P
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
Query: 40 TKYQIS----QPEVYVAAPGESLEVRCLLKDA--AVISWTKDGVHLGPNNRTVLIGEY-- 91
Y S + +++ ++++ +C + W K+G P++R IG Y
Sbjct: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR---IGGYKV 117
Query: 92 ------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVS 145
+ + P D G Y C S + ++V +
Sbjct: 118 RYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVE------------------- 158
Query: 146 ENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK----NGKE---- 197
R+P+ + V + V+F C +P P ++WLK NG +
Sbjct: 159 ------RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPD 212
Query: 198 ---FKQEHRIGGYKVRNQHWSLI-MESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSP 253
+ Q + G ++ ++ + +V D G YTC+ N G +H+ L V+E
Sbjct: 213 NLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALE 272
Query: 254 HRP 256
RP
Sbjct: 273 ERP 275
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 1001 bits (2588), Expect = 0.0
Identities = 489/650 (75%), Positives = 554/650 (85%), Gaps = 12/650 (1%)
Query: 126 DAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANTVKFRCP 180
DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVKF+CP
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSI
Sbjct: 91 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150
Query: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
NHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E NGSK
Sbjct: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
Query: 301 YGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVL 358
GPD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N IG ++ SAWLTVL
Sbjct: 211 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 270
Query: 359 PKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK 418
+A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ AVHK
Sbjct: 271 ---EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHK 327
Query: 419 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP 478
L K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+WE P
Sbjct: 328 LAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWELP 385
Query: 479 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 538
RD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SEMEM
Sbjct: 386 RDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 445
Query: 539 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 598
MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + PEEQ
Sbjct: 446 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 505
Query: 599 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 658
++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDYY
Sbjct: 506 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 565
Query: 659 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 718
KKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLK
Sbjct: 566 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 625
Query: 719 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
EGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+
Sbjct: 626 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 675
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 984 bits (2543), Expect = 0.0
Identities = 503/776 (64%), Positives = 589/776 (75%), Gaps = 57/776 (7%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
Query: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
Query: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANT 174
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA T
Sbjct: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKT 173
Query: 175 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 234
VKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VE
Sbjct: 174 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 233
Query: 235 NEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHV 294
NEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+
Sbjct: 234 NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 293
Query: 295 EKNGSKYGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYIGQANQS 352
E NGSK GPD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N IG ++ S
Sbjct: 294 EVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHS 353
Query: 353 AWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSS 412
AWLTVL +A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF S
Sbjct: 354 AWLTVL---EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHS 410
Query: 413 QPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPED 472
Q AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPED
Sbjct: 411 QMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPED 468
Query: 473 PKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDL 532
P+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL
Sbjct: 469 PRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL 528
Query: 533 VSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIN 592
+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ +
Sbjct: 529 ISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPS 588
Query: 593 RVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI 652
PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI
Sbjct: 589 HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI 648
Query: 653 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEE 712
++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEE
Sbjct: 649 HHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEE 708
Query: 713 LFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
L FKQLVEDLDRI+ LT+N+
Sbjct: 709 L-------------------------------------FKQLVEDLDRIVALTSNQ 727
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 973 bits (2514), Expect = 0.0
Identities = 494/728 (67%), Positives = 575/728 (78%), Gaps = 19/728 (2%)
Query: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Query: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
Query: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
Query: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYIC 340
DAQPHIQW+KHVE NGSK GPDG PY+ VLK +G N+++ E VL+L NVT DAGEY C
Sbjct: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTC 339
Query: 341 KVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCR 400
N IG ++ SAWL VLP ++ E A Y I Y +G FL +V V LCR
Sbjct: 340 LAGNSIGFSHHSAWLVVLPAEEELVEADE--AGSVYAGILSYGVGFFLFILVVAAVTLCR 397
Query: 401 MKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPM 460
+++ KK P VHK++ R PL+RQV S ES++SM+SNTPLVRI RLSS + P
Sbjct: 398 LRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMSSNTPLVRIA-RLSS-GEGPT 450
Query: 461 LAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML 520
LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAVKML
Sbjct: 451 LANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKML 510
Query: 521 KDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRAR 580
KDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+LRAR
Sbjct: 511 KDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRAR 570
Query: 581 RPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 640
RPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE+NV
Sbjct: 571 RPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNV 630
Query: 641 MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL 700
MKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEIFTL
Sbjct: 631 MKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTL 690
Query: 701 GGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 760
GGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR
Sbjct: 691 GGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDR 750
Query: 761 ILTLTTNE 768
+LT+T+ +
Sbjct: 751 VLTVTSTD 758
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 962 bits (2488), Expect = 0.0
Identities = 490/731 (67%), Positives = 576/731 (78%), Gaps = 23/731 (3%)
Query: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Query: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
Query: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
Query: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEV-LALFNVTEADAGEYICK 341
DAQPHIQW+KHVE NGSK GPDG PY+ VLK S A+V L L NV+E D GEY+C+
Sbjct: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCR 339
Query: 342 VSNYIGQANQSAWLTVLPKQQAPGREKEITASPD----YLEIAIYCIGVFLIACMVVTVI 397
+N+IG A ++ WL+V + A E+E+ + + Y I Y +G FL +V V
Sbjct: 340 ATNFIGVAEKAFWLSVHGPRAA---EEELVEADEAGSVYAGILSYGVGFFLFILVVAAVT 396
Query: 398 LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTAD 457
LCR+++ KK P VHK++ R PL+RQV S ES++SM+SNTPLVRI RLSS +
Sbjct: 397 LCRLRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMSSNTPLVRIA-RLSS-GE 449
Query: 458 TPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAV 517
P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAV
Sbjct: 450 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV 509
Query: 518 KMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL 577
KMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+L
Sbjct: 510 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 569
Query: 578 RARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE 637
RARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE
Sbjct: 570 RARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE 629
Query: 638 NNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI 697
+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEI
Sbjct: 630 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 689
Query: 698 FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 757
FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPTFKQLVED
Sbjct: 690 FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVED 749
Query: 758 LDRILTLTTNE 768
LDR+LT+T+ +
Sbjct: 750 LDRVLTVTSTD 760
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 842 bits (2176), Expect = 0.0
Identities = 428/496 (86%), Positives = 442/496 (89%), Gaps = 16/496 (3%)
Query: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTE 332
V+F C + P ++W+K NG ++ + + G N L + +V
Sbjct: 175 VKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLIMESVVP 223
Query: 333 ADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACM 392
+D G Y C V N G N + L V+ APGREKEITASPDYLEIAIYCIGVFLIACM
Sbjct: 224 SDKGNYTCVVENEYGSINHTYHLDVV----APGREKEITASPDYLEIAIYCIGVFLIACM 279
Query: 393 VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 452
VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL
Sbjct: 280 VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 339
Query: 453 SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 512
SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA
Sbjct: 340 SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 399
Query: 513 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 572
VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN
Sbjct: 400 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 459
Query: 573 LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN 632
LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN
Sbjct: 460 LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN 519
Query: 633 VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 692
VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV
Sbjct: 520 VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 579
Query: 693 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 752
LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK
Sbjct: 580 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 639
Query: 753 QLVEDLDRILTLTTNE 768
QLVEDLDRILTLTTNE
Sbjct: 640 QLVEDLDRILTLTTNE 655
Score = 518 bits (1334), Expect = e-147
Identities = 249/249 (100%), Positives = 249/249 (100%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 241 NHTYHLDVV 249
NHTYHLDVV
Sbjct: 241 NHTYHLDVV 249
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 837 bits (2163), Expect = 0.0
Identities = 437/751 (58%), Positives = 541/751 (72%), Gaps = 24/751 (3%)
Query: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
Query: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
Query: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
Query: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ 259
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQ
Sbjct: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ 252
Query: 260 AGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINS 319
AGLPAN + VVG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK + INS
Sbjct: 253 AGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINS 312
Query: 320 SNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPD--YL 377
S EVL L NV+ DAGEY C N IG + QSAWLTVLP++ A+P+ Y
Sbjct: 313 SEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWT----AAAPEARYT 368
Query: 378 EIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSS 437
+I +Y G +A +++ L R + + PA + R PL RQ S ES S
Sbjct: 369 DIILYASGSLALAVLLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQF--SLESGS 424
Query: 438 SMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVV 497
S S++ LVR RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV
Sbjct: 425 SGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVV 482
Query: 498 MAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ 557
AEA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ
Sbjct: 483 RAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQ 542
Query: 558 DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEY 617
+GPLYVIVE A+KGNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+Y
Sbjct: 543 EGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQY 602
Query: 618 LASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALF 677
L S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALF
Sbjct: 603 LESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALF 662
Query: 678 DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMM 737
DRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +M
Sbjct: 663 DRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLM 722
Query: 738 RDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
R+CWHA PSQRPTFKQLVE LD++L + E
Sbjct: 723 RECWHAAPSQRPTFKQLVEALDKVLLAVSEE 753
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 837 bits (2163), Expect = 0.0
Identities = 437/751 (58%), Positives = 541/751 (72%), Gaps = 24/751 (3%)
Query: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
Query: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
Query: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
Query: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ 259
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQ
Sbjct: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ 252
Query: 260 AGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINS 319
AGLPAN + VVG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK + INS
Sbjct: 253 AGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINS 312
Query: 320 SNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPD--YL 377
S EVL L NV+ DAGEY C N IG + QSAWLTVLP++ A+P+ Y
Sbjct: 313 SEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWT----AAAPEARYT 368
Query: 378 EIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSS 437
+I +Y G +A +++ L R + + PA + R PL RQ S ES S
Sbjct: 369 DIILYASGSLALAVLLLLAGLYRGQALHGR--HPRPPATVQKLSRFPLARQF--SLESGS 424
Query: 438 SMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVV 497
S S++ LVR RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV
Sbjct: 425 SGKSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVV 482
Query: 498 MAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ 557
AEA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ
Sbjct: 483 RAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQ 542
Query: 558 DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEY 617
+GPLYVIVE A+KGNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+Y
Sbjct: 543 EGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQY 602
Query: 618 LASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALF 677
L S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALF
Sbjct: 603 LESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALF 662
Query: 678 DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMM 737
DRVYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +M
Sbjct: 663 DRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLM 722
Query: 738 RDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
R+CWHA PSQRPTFKQLVE LD++L + E
Sbjct: 723 RECWHAAPSQRPTFKQLVEALDKVLLAVSEE 753
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 813 bits (2099), Expect = 0.0
Identities = 430/749 (57%), Positives = 522/749 (69%), Gaps = 60/749 (8%)
Query: 24 SFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNN 83
S E+ LEP P+ Q Q + A G+ + + C + W K+G L P
Sbjct: 21 SLEASEEVELEPCLAPSLEQ--QEQELTVALGQPVRLCCGRAERGG-HWYKEGSRLAPAG 77
Query: 84 RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----DAISSGDDEDDTDG 139
R L+I P D+G Y C A ++ + N+T D+++S +D++D
Sbjct: 78 RVRGWRGRLEIASFLPEDAGRYLCLARGSM-----IVLQNLTLITGDSLTSSNDDEDPKS 132
Query: 140 AEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 199
D + +S ++APYWT+ ++MEK+LHAVPA NTVKFRCPA GNP PT+RWLK+G+ F
Sbjct: 133 HRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFH 192
Query: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ 259
E+RIGG ++R+QHWSL+MESVVPSD+G YTC+VEN GSI + Y LDV+ERSPHRPILQ
Sbjct: 193 GENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQ 252
Query: 260 AGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINS 319
AGLPAN + VVG DVE +CKVYSDAQPHIQW+KH+ NGS +G DG PY++VLK + INS
Sbjct: 253 AGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINS 312
Query: 320 SNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEI 379
S EVL L NV+ DAGEY C N IG + QSAWLTVLP GR +T D L
Sbjct: 313 SEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP---GTGRIPHLTC--DSLTP 367
Query: 380 AIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM 439
A TK P S ES SS
Sbjct: 368 A----------------------GRTKSPTLQ-------------------FSLESGSSG 386
Query: 440 NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMA 499
S++ LVR RLSS+ +LAG+ +LP DP WEFPRD+L LGKPLGEGCFGQVV A
Sbjct: 387 KSSSSLVR-GVRLSSSGPA-LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRA 444
Query: 500 EAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG 559
EA G+D +P +A TVAVKMLKD+A++KDL+DLVSEME+MK+IG+HKNIINLLG CTQ+G
Sbjct: 445 EAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEG 504
Query: 560 PLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA 619
PLYVIVE A+KGNLRE+LRARRPPG + S D R E ++F LVSC YQ+ARGM+YL
Sbjct: 505 PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 564
Query: 620 SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDR 679
S+KCIHRDLAARNVLVTE+NVMKIADFGLAR +++IDYYKKT+NGRLPVKWMAPEALFDR
Sbjct: 565 SRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDR 624
Query: 680 VYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRD 739
VYTHQSDVWSFG+L+WEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C ELY +MR+
Sbjct: 625 VYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRE 684
Query: 740 CWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
CWHA PSQRPTFKQLVE LD++L + E
Sbjct: 685 CWHAAPSQRPTFKQLVEALDKVLLAVSEE 713
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 699 bits (1803), Expect = 0.0
Identities = 372/501 (74%), Positives = 399/501 (79%), Gaps = 30/501 (5%)
Query: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTE 332
V+F C + P ++W+K NG ++ + + G N L + +V
Sbjct: 175 VKFRCPAGGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLIMESVVP 223
Query: 333 ADAGEYICKVSNYIGQANQSAWLTVLPKQ-QAPGREKEITASPDYL---EIAIYCIGVFL 388
+D G Y C V N G N + L V+ + P + + A+ + ++ C V+
Sbjct: 224 SDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVC-KVYS 282
Query: 389 IACMVVTVILCRMKNTTKK-PDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR 447
A + I KN +K PD +P + + VSAESSSSMNSNTPLVR
Sbjct: 283 DAQPHIQWIKHVEKNGSKYGPD------------GLPYLKVLKVSAESSSSMNSNTPLVR 330
Query: 448 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 507
ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD
Sbjct: 331 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 390
Query: 508 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 567
KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY
Sbjct: 391 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 450
Query: 568 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 627
ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD
Sbjct: 451 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 510
Query: 628 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 687
LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV
Sbjct: 511 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 570
Query: 688 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 747
WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ
Sbjct: 571 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 630
Query: 748 RPTFKQLVEDLDRILTLTTNE 768
RPTFKQLVEDLDRILTLTTNE
Sbjct: 631 RPTFKQLVEDLDRILTLTTNE 651
Score = 654 bits (1688), Expect = 0.0
Identities = 316/321 (98%), Positives = 318/321 (99%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
Sbjct: 61 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 120
Query: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
Sbjct: 121 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 180
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
Sbjct: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
Query: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
Sbjct: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
Query: 301 YGPDGLPYLKVLKHSGINSSN 321
YGPDGLPYLKVLK S +SS+
Sbjct: 301 YGPDGLPYLKVLKVSAESSSS 321
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 598 bits (1541), Expect = e-171
Identities = 317/503 (63%), Positives = 371/503 (73%), Gaps = 36/503 (7%)
Query: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEA 333
V F C + P I W+K+ + ++ G+ L+H + L + +V +
Sbjct: 172 VRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIK----LRHQQWS------LVMESVVPS 221
Query: 334 DAGEYICKVSNYIGQANQSAWLTVL------PKQQA--PGREKEITASPDYLEIAIYCIG 385
D G Y C V N G Q+ L VL P QA P + + S ++ +C
Sbjct: 222 DRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGS----DVEFHCKV 277
Query: 386 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPL 445
+ + + + PD + V K VS ES++SM+SNTPL
Sbjct: 278 YSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLK------------VSLESNASMSSNTPL 325
Query: 446 VRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 505
VRI RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GID
Sbjct: 326 VRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGID 383
Query: 506 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 565
KD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+V
Sbjct: 384 KDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLV 443
Query: 566 EYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIH 625
EYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIH
Sbjct: 444 EYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIH 503
Query: 626 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 685
RDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQS
Sbjct: 504 RDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 563
Query: 686 DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVP 745
DVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA P
Sbjct: 564 DVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAP 623
Query: 746 SQRPTFKQLVEDLDRILTLTTNE 768
SQRPTFKQLVEDLDR+LT+T+ +
Sbjct: 624 SQRPTFKQLVEDLDRVLTVTSTD 646
Score = 325 bits (833), Expect = 1e-88
Identities = 167/296 (56%), Positives = 204/296 (68%), Gaps = 9/296 (3%)
Query: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Query: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
Query: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
Query: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
Query: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHS-GINSSNAEVLALFNVTEADAGE 337
DAQPHIQW+KHVE NGSK GPDG PY+ VLK S N+S + L + +GE
Sbjct: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGE 335
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 324 bits (830), Expect = 2e-88
Identities = 170/344 (49%), Positives = 224/344 (65%), Gaps = 20/344 (5%)
Query: 435 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 487
SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK
Sbjct: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
Query: 488 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 546
LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H
Sbjct: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
Query: 547 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 598
++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E
Sbjct: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
Query: 599 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 658
+T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y
Sbjct: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
Query: 659 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 718
K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
Query: 719 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762
GHRM++P NC+ E+Y +M CW P +RP F + +DL++++
Sbjct: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 324 bits (830), Expect = 2e-88
Identities = 170/344 (49%), Positives = 224/344 (65%), Gaps = 20/344 (5%)
Query: 435 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 487
SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK
Sbjct: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
Query: 488 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 546
LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H
Sbjct: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
Query: 547 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 598
++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E
Sbjct: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
Query: 599 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 658
+T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y
Sbjct: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
Query: 659 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 718
K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
Query: 719 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762
GHRM++P NC+ E+Y +M CW P +RP F + +DL++++
Sbjct: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 323 bits (827), Expect = 5e-88
Identities = 230/607 (37%), Positives = 303/607 (49%), Gaps = 127/607 (20%)
Query: 216 LIMESVVPS--DKGNYTCVVENEYGSINHTY--HLDVVERSPHRPILQAGLPANASTVVG 271
LIME S D+G+Y C+ ++ H L V+ER P + L N +T +G
Sbjct: 625 LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIG 681
Query: 272 GDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVT 331
+E C + P I W K N + G+ VLK N L + V
Sbjct: 682 ESIEVSCTASGNPPPQIMWFKD---NETLVEDSGI----VLKDGNRN------LTIRRVR 728
Query: 332 EADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIAC 391
+ D G Y C+ + +G A A+ + Q+ E I +G +IA
Sbjct: 729 KEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLE------------IIILVGTAVIAM 776
Query: 392 M--VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRIT 449
++ VI+ R TV + + T
Sbjct: 777 FFWLLLVIILR-----------------------------TVKRANGGELK--------T 799
Query: 450 TRLSSTADTPMLAGVSEYE-LPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 507
LS D L E LP D KWEFPRD+L LGKPLG G FGQV+ A+A GIDK
Sbjct: 800 GYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKT 859
Query: 508 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVE 566
TVAVKMLK+ AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE
Sbjct: 860 ATCR--TVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVE 917
Query: 567 YASKGNLREYLRARRPPGMEYS-----------------YDINR---------------- 593
+ GNL YLR++R + Y D+ R
Sbjct: 918 FCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGF 977
Query: 594 --------VPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT 636
V EE+ +T + L+ ++Q+A+GME+LAS+KCIHRDLAARN+L++
Sbjct: 978 VEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLS 1037
Query: 637 ENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWE 696
E NV+KI DFGLARDI Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVL+WE
Sbjct: 1038 EKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWE 1097
Query: 697 IFTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLV 755
IF+LG SPYPG+ ++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LV
Sbjct: 1098 IFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELV 1157
Query: 756 EDLDRIL 762
E L +L
Sbjct: 1158 EHLGNLL 1164
Score = 45.4 bits (106), Expect = 2e-04
Identities = 54/208 (25%), Positives = 79/208 (37%), Gaps = 38/208 (18%)
Query: 92 LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
L I G T D GLY C AS + ++ V V + + FV+ S
Sbjct: 292 LTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHE--------------KPFVAFGSG-- 335
Query: 152 RAPYWTNTEKMEKRLHAVPAANTVKFRCPAG--GNPMPTMRWLKNGKEFKQEHRIGGYKV 209
ME + A + R PA G P P ++W KNG + H I
Sbjct: 336 ----------MESLVEATVGE---RVRIPAKYLGYPPPEIKWYKNGIPLESNHTI----- 377
Query: 210 RNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTV 269
+ H IME V D GNYT ++ N ++ + +V P + ++ + S
Sbjct: 378 KAGHVLTIME-VSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQ 436
Query: 270 VGGDVEFVCKVYSDAQP-HIQWIKHVEK 296
G C VY+ P HI W +E+
Sbjct: 437 YGTTQTLTCTVYAIPPPHHIHWYWQLEE 464
Score = 37.7 bits (86), Expect = 0.041
Identities = 34/140 (24%), Positives = 56/140 (40%), Gaps = 22/140 (15%)
Query: 215 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQ--AGLPANASTVVGG 272
+L ++ V SD+G YTC + + ++ + V E +P + +G+ + VG
Sbjct: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHE----KPFVAFGSGMESLVEATVGE 346
Query: 273 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTE 332
V K P I+W K +G+P S VL + V+E
Sbjct: 347 RVRIPAKYLGYPPPEIKWYK-----------NGIPL-----ESNHTIKAGHVLTIMEVSE 390
Query: 333 ADAGEYICKVSNYIGQANQS 352
D G Y ++N I + QS
Sbjct: 391 RDTGNYTVILTNPISKEKQS 410
Score = 36.2 bits (82), Expect = 0.12
Identities = 19/75 (25%), Positives = 38/75 (50%), Gaps = 5/75 (6%)
Query: 157 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
T T +E + ++ +++ C A GNP P + W K+ + ++ G +++ + +L
Sbjct: 668 TITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNL 722
Query: 217 IMESVVPSDKGNYTC 231
+ V D+G YTC
Sbjct: 723 TIRRVRKEDEGLYTC 737
Score = 30.0 bits (66), Expect = 8.5
Identities = 16/55 (29%), Positives = 27/55 (49%), Gaps = 1/55 (1%)
Query: 70 ISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNV 124
I W K+G+ L +N T+ G L I + RD+G Y + + E +V++
Sbjct: 362 IKWYKNGIPL-ESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSL 415
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 318 bits (816), Expect = 9e-87
Identities = 215/605 (35%), Positives = 298/605 (49%), Gaps = 123/605 (20%)
Query: 215 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274
+L + +V D G Y C N Y ++ R P L L ++ + +
Sbjct: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISSST 678
Query: 275 EFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEAD 334
C +P I W K+ K + G I + L + VTE D
Sbjct: 679 TLDCHANGVPEPQITWFKNNHKIQQEPGI-------------ILGPGSSTLFIERVTEED 725
Query: 335 AGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVV 394
G Y CK +N G SA+LTV E + + C+ L +++
Sbjct: 726 EGVYHCKATNQKGSVESSAYLTVQGTSDKSNLE--------LITLTCTCVAATLF-WLLL 776
Query: 395 TVILCRMKNTTK--KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 452
T+ + +MK ++ K D+ S + +PL Q
Sbjct: 777 TLFIRKMKRSSSEIKTDYLS---IIMDPDEVPLDEQCE---------------------- 811
Query: 453 SSTADTPMLAGVSEYELPEDP-KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKE 511
LP D KWEF R++L LGK LG G FG+VV A A GI K
Sbjct: 812 ---------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR 856
Query: 512 AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASK 570
TVAVKMLK+ AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY
Sbjct: 857 --TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKY 914
Query: 571 GNLREYLRARRP--------------------PGMEYSY--------------------- 589
GNL YL+++R PG+E
Sbjct: 915 GNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQED 974
Query: 590 -DINRVPEEQ---------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN 639
++ V EE+ +T +DL+S ++Q+ARGME+L+S+KCIHRDLAARN+L++ENN
Sbjct: 975 KSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENN 1034
Query: 640 VMKIADFGLARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIF 698
V+KI DFGLARDI N DY +K RLP+KWMAPE++FD++Y+ +SDVWS+GVL+WEIF
Sbjct: 1035 VVKICDFGLARDIYKNPDYVRKGDT-RLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIF 1093
Query: 699 TLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 757
+LGGSPYPG+ ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE
Sbjct: 1094 SLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEK 1153
Query: 758 LDRIL 762
L +L
Sbjct: 1154 LGDLL 1158
Score = 46.2 bits (108), Expect = 1e-04
Identities = 39/157 (24%), Positives = 58/157 (36%), Gaps = 29/157 (18%)
Query: 92 LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNK 151
L I + +DSG YAC A E +T ++
Sbjct: 621 LTIMNVSLQDSGTYACRARNVYTGEEILQKKEIT----------------------IRDQ 658
Query: 152 RAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRN 211
APY H V +++ C A G P P + W KN + +QE G +
Sbjct: 659 EAPYLLRNLSD----HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGP 711
Query: 212 QHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDV 248
+L +E V D+G Y C N+ GS+ + +L V
Sbjct: 712 GSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTV 748
Score = 42.0 bits (97), Expect = 0.002
Identities = 64/300 (21%), Positives = 111/300 (37%), Gaps = 36/300 (12%)
Query: 157 TNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
T + ++ L V + + P P + WLK+G + Y R +SL
Sbjct: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRG--YSL 390
Query: 217 IMESVVPSDKGNYTCVV----ENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 272
I++ V D GNYT ++ N + ++ T ++V + + + + P A +G
Sbjct: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
Query: 273 DVEFVCKVYSDAQPHIQWIKH-VEKNGSKYGPD-----------------GLPYLKVLKH 314
C Y QP I+W H N S+ D G + +
Sbjct: 449 RQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQR 508
Query: 315 SGINSSNAEVLALFNVTEAD-AGEYICKVSNYIGQA--NQSAWLTVLPKQQAPGREKEIT 371
I ++ + V ++ +G YIC SN +G N S ++T +P EK T
Sbjct: 509 MAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT 568
Query: 372 ASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTV 431
D + + C + V ++L + N T S Q +TK + +T+
Sbjct: 569 EGED---LKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMA--ITKEHSITLNLTI 623
>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
[Homo sapiens]
Length = 300
Score = 296 bits (759), Expect = 4e-80
Identities = 135/191 (70%), Positives = 157/191 (82%), Gaps = 3/191 (1%)
Query: 126 DAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVKFRCPAG 182
DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVKF+CP+
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 90
Query: 183 GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH 242
G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSINH
Sbjct: 91 GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 150
Query: 243 TYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYG 302
TY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E NGSK G
Sbjct: 151 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 210
Query: 303 PDGLPYLKVLK 313
PD LPY+++LK
Sbjct: 211 PDNLPYVQILK 221
Score = 35.4 bits (80), Expect = 0.20
Identities = 45/229 (19%), Positives = 76/229 (33%), Gaps = 63/229 (27%)
Query: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEE---------------------PP 39
M SW + V+ ATL ARPS +L E L E P
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
Query: 40 TKYQIS----QPEVYVAAPGESLEVRCLLKDA--AVISWTKDGVHLGPNNRTVLIGEY-- 91
Y S + +++ ++++ +C + W K+G P++R IG Y
Sbjct: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHR---IGGYKV 117
Query: 92 ------LQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVS 145
+ + P D G Y C S + ++V +
Sbjct: 118 RYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVE------------------- 158
Query: 146 ENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKN 194
R+P+ + V + V+F C +P P ++WLK+
Sbjct: 159 ------RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKH 201
Score = 31.2 bits (69), Expect = 3.8
Identities = 23/88 (26%), Positives = 37/88 (42%), Gaps = 12/88 (13%)
Query: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTE 332
V+F C P ++W+K NG ++ PD + G A + + +V
Sbjct: 83 VKFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRYATWSIIMDSVVP 131
Query: 333 ADAGEYICKVSNYIGQANQSAWLTVLPK 360
+D G Y C V N G N + L V+ +
Sbjct: 132 SDKGNYTCIVENEYGSINHTYQLDVVER 159
>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
[Homo sapiens]
Length = 302
Score = 296 bits (757), Expect = 6e-80
Identities = 135/193 (69%), Positives = 157/193 (81%), Gaps = 5/193 (2%)
Query: 126 DAISSGDDEDDTDGAEDFVSENSNNKR-----APYWTNTEKMEKRLHAVPAANTVKFRCP 180
DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVKF+CP
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90
Query: 181 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 240
+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSI
Sbjct: 91 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150
Query: 241 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 300
NHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E NGSK
Sbjct: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
Query: 301 YGPDGLPYLKVLK 313
GPD LPY+++LK
Sbjct: 211 IGPDNLPYVQILK 223
Score = 31.2 bits (69), Expect = 3.8
Identities = 23/88 (26%), Positives = 37/88 (42%), Gaps = 12/88 (13%)
Query: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTE 332
V+F C P ++W+K NG ++ PD + G A + + +V
Sbjct: 85 VKFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRYATWSIIMDSVVP 133
Query: 333 ADAGEYICKVSNYIGQANQSAWLTVLPK 360
+D G Y C V N G N + L V+ +
Sbjct: 134 SDKGNYTCIVENEYGSINHTYQLDVVER 161
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 289 bits (739), Expect = 8e-78
Identities = 209/669 (31%), Positives = 322/669 (48%), Gaps = 125/669 (18%)
Query: 215 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHR--PILQAGLPANASTVVGG 272
+L + S +D G + C N +GS N T L+VV++ P++ + N G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVND----GE 329
Query: 273 DVEFVCKVYSDAQP-HIQWI--------------KHVEKNGSKY----------GPDGLP 307
+V+ + + + +P H QWI K ++ +Y G +G
Sbjct: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGT 389
Query: 308 YLKVLKHSGINSSNAEVLALFNV---TEADAGEYICKVSNYIGQANQSAWLTVLPKQQAP 364
Y ++ +S +N++ A FNV T+ + Y V+ + + P
Sbjct: 390 YTFLVSNSDVNAAIA-----FNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCP 444
Query: 365 GREKEITASPDYLEIAIYC-----IGVFLIACMVVT-------VILCRMKNTTKKP---- 408
G E+ +AS +++ G ++ + + + C+ N K
Sbjct: 445 GTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYF 504
Query: 409 DFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNS-------NTPLVRITTRLSSTADTPML 461
+F+ + +H T PL + A + P+ + ++ +
Sbjct: 505 NFAFKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNY 564
Query: 462 AGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK 521
+ +LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK
Sbjct: 565 VYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLK 622
Query: 522 DDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR 581
A + L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 623 PSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKR 682
Query: 582 P--------------------------------------PGMEY----------SYDINR 593
PG+ Y S I
Sbjct: 683 DSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGS 742
Query: 594 VPEEQMT------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM 641
E +T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T +
Sbjct: 743 YIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT 802
Query: 642 KIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLG 701
KI DFGLARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG
Sbjct: 803 KICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLG 862
Query: 702 GSPYPGIPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 760
SPYPG+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++
Sbjct: 863 SSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK 922
Query: 761 ILTLTTNEI 769
++ +TN I
Sbjct: 923 QISESTNHI 931
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 287 bits (734), Expect = 3e-77
Identities = 157/363 (43%), Positives = 215/363 (59%), Gaps = 63/363 (17%)
Query: 468 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 527
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632
Query: 528 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 582
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
Query: 583 ---------------------------------PGMEY----------SYDINRVPEEQM 599
PG+ Y S I E +
Sbjct: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752
Query: 600 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 647
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812
Query: 648 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 707
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872
Query: 708 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 766
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932
Query: 767 NEI 769
N I
Sbjct: 933 NHI 935
Score = 30.0 bits (66), Expect = 8.5
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 7/80 (8%)
Query: 215 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHR--PILQAGLPANASTVVGG 272
+L + S +D G + C N +GS N T L+VV++ P++ + N G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVND----GE 329
Query: 273 DVEFVCKVYSDAQP-HIQWI 291
+V+ + + + +P H QWI
Sbjct: 330 NVDLIVEYEAFPKPEHQQWI 349
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 244 bits (623), Expect = 2e-64
Identities = 128/275 (46%), Positives = 182/275 (66%), Gaps = 8/275 (2%)
Query: 488 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 547
+GEG FGQV+ A I KD + + A+K +K+ A++ D D E+E++ +G H N
Sbjct: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
Query: 548 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 607
IINLLGAC G LY+ +EYA GNL ++LR R + ++ I ++ + L+
Sbjct: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
Query: 608 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 667
+ARGM+YL+ ++ IHRDLAARN+LV EN V KIADFGL+R + Y K T GRLP
Sbjct: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
Query: 668 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 727
V+WMA E+L VYT SDVWS+GVL+WEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
Query: 728 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762
NC +E+Y +MR CW P +RP+F Q++ L+R+L
Sbjct: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 244 bits (623), Expect = 2e-64
Identities = 132/283 (46%), Positives = 180/283 (63%), Gaps = 8/283 (2%)
Query: 480 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 539
+ +T +GEG FGQV+ A I KD K + A+KMLK+ A+E D D E+E++
Sbjct: 837 EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891
Query: 540 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 599
+G H NIINLLGAC G LY+ +EYA GNL ++LR R + ++ +
Sbjct: 892 CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951
Query: 600 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 659
+ + L+ A GM+YL+ ++ IHRDLAARNVLV EN KIADFGL+R + Y
Sbjct: 952 SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008
Query: 660 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 719
K T GRLPV+WMA E+L VYT +SDVWSFGVL+WEI +LGG+PY G+ EL++ L +
Sbjct: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068
Query: 720 GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762
G+RM++P NC +E+Y +MR CW P +RP F Q+ L R+L
Sbjct: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRML 1111
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,891,598
Number of Sequences: 37866
Number of extensions: 1425676
Number of successful extensions: 10023
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 703
Number of HSP's successfully gapped in prelim test: 360
Number of HSP's that attempted gapping in prelim test: 3997
Number of HSP's gapped (non-prelim): 3320
length of query: 769
length of database: 18,247,518
effective HSP length: 110
effective length of query: 659
effective length of database: 14,082,258
effective search space: 9280208022
effective search space used: 9280208022
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.