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Search of human proteins with 22035598
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22035598 mitogen-activated protein kinase kinase kinase 8
[Homo sapiens]
(467 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22035598 mitogen-activated protein kinase kinase kinase 8 [Ho... 947 0.0
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 144 2e-34
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 142 8e-34
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 142 8e-34
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 135 6e-32
gi|115298645 mitogen-activated protein kinase kinase kinase 14 [... 131 1e-30
gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Hom... 125 6e-29
gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Hom... 122 5e-28
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 122 9e-28
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 122 9e-28
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 122 9e-28
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 122 9e-28
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 122 9e-28
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 122 9e-28
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 122 9e-28
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 122 9e-28
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 119 4e-27
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 118 1e-26
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 118 1e-26
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 118 1e-26
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 117 2e-26
gi|191252782 p21-activated kinase 6 [Homo sapiens] 117 2e-26
gi|191252780 p21-activated kinase 6 [Homo sapiens] 117 2e-26
gi|9910476 p21-activated kinase 6 [Homo sapiens] 117 2e-26
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 117 3e-26
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 117 3e-26
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 117 3e-26
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 117 3e-26
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 117 3e-26
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 117 3e-26
>gi|22035598 mitogen-activated protein kinase kinase kinase 8 [Homo
sapiens]
Length = 467
Score = 947 bits (2447), Expect = 0.0
Identities = 467/467 (100%), Positives = 467/467 (100%)
Query: 1 MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERS 60
MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERS
Sbjct: 1 MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERS 60
Query: 61 KSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGR 120
KSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGR
Sbjct: 61 KSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGR 120
Query: 121 YQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE 180
YQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE
Sbjct: 121 YQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE 180
Query: 181 IQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKG 240
IQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKG
Sbjct: 181 IQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKG 240
Query: 241 LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL 300
LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL
Sbjct: 241 LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL 300
Query: 301 CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPG 360
CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPG
Sbjct: 301 CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPG 360
Query: 361 MRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELP 420
MRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELP
Sbjct: 361 MRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELP 420
Query: 421 ENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG 467
ENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
Sbjct: 421 ENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG 467
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 144 bits (363), Expect = 2e-34
Identities = 89/250 (35%), Positives = 140/250 (56%), Gaps = 14/250 (5%)
Query: 144 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFR------HENIAELYGAV 197
I +G+FG+V+ D +T++ +A K+I +++ + +IQ + + YG+
Sbjct: 30 IGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSY 89
Query: 198 LWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPS 257
L G + + ME GGS L+ L + GP EF+I + K +LKGLD+LHS+K IH DIK +
Sbjct: 90 LKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAA 148
Query: 258 NIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGAT 316
N++ V L DFG++ Q+T+ GT +M+PEVI + +KADI+SLG T
Sbjct: 149 NVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGIT 208
Query: 317 LIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHR 376
I + G PP +P L++I K PP + D + +E I+A L ++P+ R
Sbjct: 209 AIELAKGEPPNSDMHPMRV----LFLIPKNNPP--TLVGDFTKSFKEFIDACLNKDPSFR 262
Query: 377 PRAADLLKHE 386
P A +LLKH+
Sbjct: 263 PTAKELLKHK 272
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 142 bits (357), Expect = 8e-34
Identities = 89/250 (35%), Positives = 142/250 (56%), Gaps = 14/250 (5%)
Query: 144 IPRGAFGKVYLAQDIKTKKRMACKLIPV----DQFKPSDVEIQACFRHEN--IAELYGAV 197
I +G+FG+V+ D +T+K +A K+I + D+ + EI + ++ + + YG+
Sbjct: 30 IGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSY 89
Query: 198 LWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPS 257
L + + ME GGS L+ LE GP+ E +I + + +LKGLD+LHS+K IH DIK +
Sbjct: 90 LKDTKLWIIMEYLGGGSALDLLEP-GPLDETQIATILREILKGLDYLHSEKKIHRDIKAA 148
Query: 258 NIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGAT 316
N++ V L DFG++ Q+T+ GT +M+PEVI + +KADI+SLG T
Sbjct: 149 NVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGIT 208
Query: 317 LIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHR 376
I + G PP + +P L++I K PP + + S ++E +EA L + P+ R
Sbjct: 209 AIELARGEPPHSELHPMKV----LFLIPKNNPP--TLEGNYSKPLKEFVEACLNKEPSFR 262
Query: 377 PRAADLLKHE 386
P A +LLKH+
Sbjct: 263 PTAKELLKHK 272
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 142 bits (357), Expect = 8e-34
Identities = 89/250 (35%), Positives = 142/250 (56%), Gaps = 14/250 (5%)
Query: 144 IPRGAFGKVYLAQDIKTKKRMACKLIPV----DQFKPSDVEIQACFRHEN--IAELYGAV 197
I +G+FG+V+ D +T+K +A K+I + D+ + EI + ++ + + YG+
Sbjct: 42 IGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSY 101
Query: 198 LWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPS 257
L + + ME GGS L+ LE GP+ E +I + + +LKGLD+LHS+K IH DIK +
Sbjct: 102 LKDTKLWIIMEYLGGGSALDLLEP-GPLDETQIATILREILKGLDYLHSEKKIHRDIKAA 160
Query: 258 NIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGAT 316
N++ V L DFG++ Q+T+ GT +M+PEVI + +KADI+SLG T
Sbjct: 161 NVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGIT 220
Query: 317 LIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHR 376
I + G PP + +P L++I K PP + + S ++E +EA L + P+ R
Sbjct: 221 AIELARGEPPHSELHPMKV----LFLIPKNNPP--TLEGNYSKPLKEFVEACLNKEPSFR 274
Query: 377 PRAADLLKHE 386
P A +LLKH+
Sbjct: 275 PTAKELLKHK 284
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 135 bits (341), Expect = 6e-32
Identities = 97/302 (32%), Positives = 154/302 (50%), Gaps = 18/302 (5%)
Query: 142 DFIPRGAFGKVYLAQDIKTKKRMACKLIPV----DQFKPSDVEIQACFRHEN--IAELYG 195
D I +G+FG+VY D TK+ +A K+I + D+ + EI + ++ I +G
Sbjct: 24 DRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFG 83
Query: 196 AVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIK 255
+ L + + ME GGS L+ L+ GP+ E I + + +LKGLD+LHS++ IH DIK
Sbjct: 84 SYLKSTKLWIIMEYLGGGSALDLLKP-GPLEETYIATILREILKGLDYLHSERKIHRDIK 142
Query: 256 PSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLG 314
+N++ V L DFG++ Q+T+ GT +M+PEVI + KADI+SLG
Sbjct: 143 AANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLG 202
Query: 315 ATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPN 374
T I + G PP +P L++I K +PP + S +E +EA L ++P
Sbjct: 203 ITAIELAKGEPPNSDLHPMRV----LFLIPKNSPP--TLEGQHSKPFKEFVEACLNKDPR 256
Query: 375 HRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELPENIADSSCTGSTEE 434
RP A +LLKH+ + + S + L++R + + + DS G E+
Sbjct: 257 FRPTAKELLKHKFIT----RYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAED 312
Query: 435 SE 436
E
Sbjct: 313 GE 314
>gi|115298645 mitogen-activated protein kinase kinase kinase 14
[Homo sapiens]
Length = 947
Score = 131 bits (329), Expect = 1e-30
Identities = 86/283 (30%), Positives = 146/283 (51%), Gaps = 21/283 (7%)
Query: 107 GILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMAC 166
G+LL + P + Y+ + + W +G RG+FG+V+ +D +T + A
Sbjct: 379 GVLLTEKLKPVDYEYREE-----VHWATHQLRLG-----RGSFGEVHRMEDKQTGFQCAV 428
Query: 167 KLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMR 226
K + ++ F+ ++ A I LYGAV G V++FME EGGS+ + ++ G +
Sbjct: 429 KKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLP 488
Query: 227 EFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMS--TKAVLVDFGLSVQMTED---- 280
E ++ L+GL++LHS++++H D+K N++ S + A L DFG +V + D
Sbjct: 489 EDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGK 548
Query: 281 -VYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSY 339
+ + GTE +M+PEV+L R K D++S ++HM G PW + + P
Sbjct: 549 SLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF---RGPLC 605
Query: 340 LYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADL 382
L I + PP+ +I C+P + I+ L + P HR AA+L
Sbjct: 606 LKIA-SEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAEL 647
>gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Homo
sapiens]
Length = 339
Score = 125 bits (315), Expect = 6e-29
Identities = 76/195 (38%), Positives = 111/195 (56%), Gaps = 13/195 (6%)
Query: 193 LYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHH 252
+ G+ LW + ME GGS L+ L + GP EF+I + K +LKGLD+LHS+K IH
Sbjct: 13 MQGSKLW-----IIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHSEKKIHR 66
Query: 253 DIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIY 311
DIK +N++ V L DFG++ Q+T+ GT +M+PEVI + +KADI+
Sbjct: 67 DIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIW 126
Query: 312 SLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLER 371
SLG T I + G PP +P L++I K PP + D + +E I+A L +
Sbjct: 127 SLGITAIELAKGEPPNSDMHPMRV----LFLIPKNNPP--TLVGDFTKSFKEFIDACLNK 180
Query: 372 NPNHRPRAADLLKHE 386
+P+ RP A +LLKH+
Sbjct: 181 DPSFRPTAKELLKHK 195
>gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Homo
sapiens]
Length = 1374
Score = 122 bits (307), Expect = 5e-28
Identities = 104/346 (30%), Positives = 169/346 (48%), Gaps = 26/346 (7%)
Query: 114 ITPQNGRYQIDSDVL--LIPWKLTYRNIGSDFI-PRGAFGKVYLAQDIKTKKRMACKLIP 170
IT + GR + D L+ + Y G + +G +G VY +D+ + R+A K IP
Sbjct: 653 ITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIP 712
Query: 171 VDQFKPS-----DVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLES-CGP 224
+ S ++ + +H+NI + G+ + +FME GGS+ L S GP
Sbjct: 713 ERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGP 772
Query: 225 MREFE--IIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVL--VDFGLSVQMTED 280
+++ E I + TK +L+GL +LH +++H DIK N++ + VL DFG S ++
Sbjct: 773 LKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGI 832
Query: 281 VYFPKDLRGTEIYMSPEVI--LCRGHSTKADIYSLGATLIHMQTGTPPWVK-RYPRSA-Y 336
+ GT YM+PE+I RG+ ADI+SLG T+I M TG PP+ + P++A +
Sbjct: 833 NPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMF 892
Query: 337 PSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEAL---NPPRE 393
++ +H + P + S + I E +P+ R A DLL E L + ++
Sbjct: 893 KVGMFKVHPEIP------ESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKK 946
Query: 394 DQPRCQSLDSALLERKRLLSRKELELPENIADSSCTGSTEESEMLK 439
QP+ +L + E R +S L E+ + SS GS LK
Sbjct: 947 TQPKLSALSAGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELK 992
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 122 bits (305), Expect = 9e-28
Identities = 96/316 (30%), Positives = 152/316 (48%), Gaps = 34/316 (10%)
Query: 142 DFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE-----IQACFRHENIAELYGA 196
+ + G +G+VY + +KT + A K++ V + +++ ++ H NIA YGA
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 197 VL------WGETVHLFMEAGEGGSVLEKLESC--GPMREFEIIWVTKHVLKGLDFLHSKK 248
+ + + L ME GSV + +++ ++E I ++ + +L+GL LH K
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHK 148
Query: 249 VIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILC-----R 302
VIH DIK N++ V LVDFG+S Q+ V GT +M+PEVI C
Sbjct: 149 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 GHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQ-APPLEDIADDCSPGM 361
+ K+D++SLG T I M G PP +P A L++I + AP L+ + S
Sbjct: 209 TYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA----LFLIPRNPAPRLK--SKKWSKKF 262
Query: 362 RELIEASLERNPNHRPRAADLLKHEAL-NPPREDQPRCQSLDSALLERKRLLSRKELELP 420
+ IE+ L +N + RP L+KH + + P E Q R Q D +K+ + E E
Sbjct: 263 QSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY- 321
Query: 421 ENIADSSCTGSTEESE 436
+GS EE E
Sbjct: 322 ------EYSGSEEEEE 331
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 122 bits (305), Expect = 9e-28
Identities = 96/316 (30%), Positives = 152/316 (48%), Gaps = 34/316 (10%)
Query: 142 DFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE-----IQACFRHENIAELYGA 196
+ + G +G+VY + +KT + A K++ V + +++ ++ H NIA YGA
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 197 VL------WGETVHLFMEAGEGGSVLEKLESC--GPMREFEIIWVTKHVLKGLDFLHSKK 248
+ + + L ME GSV + +++ ++E I ++ + +L+GL LH K
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHK 148
Query: 249 VIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILC-----R 302
VIH DIK N++ V LVDFG+S Q+ V GT +M+PEVI C
Sbjct: 149 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 GHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQ-APPLEDIADDCSPGM 361
+ K+D++SLG T I M G PP +P A L++I + AP L+ + S
Sbjct: 209 TYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA----LFLIPRNPAPRLK--SKKWSKKF 262
Query: 362 RELIEASLERNPNHRPRAADLLKHEAL-NPPREDQPRCQSLDSALLERKRLLSRKELELP 420
+ IE+ L +N + RP L+KH + + P E Q R Q D +K+ + E E
Sbjct: 263 QSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY- 321
Query: 421 ENIADSSCTGSTEESE 436
+GS EE E
Sbjct: 322 ------EYSGSEEEEE 331
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 122 bits (305), Expect = 9e-28
Identities = 96/316 (30%), Positives = 152/316 (48%), Gaps = 34/316 (10%)
Query: 142 DFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE-----IQACFRHENIAELYGA 196
+ + G +G+VY + +KT + A K++ V + +++ ++ H NIA YGA
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 197 VL------WGETVHLFMEAGEGGSVLEKLESC--GPMREFEIIWVTKHVLKGLDFLHSKK 248
+ + + L ME GSV + +++ ++E I ++ + +L+GL LH K
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHK 148
Query: 249 VIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILC-----R 302
VIH DIK N++ V LVDFG+S Q+ V GT +M+PEVI C
Sbjct: 149 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 GHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQ-APPLEDIADDCSPGM 361
+ K+D++SLG T I M G PP +P A L++I + AP L+ + S
Sbjct: 209 TYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA----LFLIPRNPAPRLK--SKKWSKKF 262
Query: 362 RELIEASLERNPNHRPRAADLLKHEAL-NPPREDQPRCQSLDSALLERKRLLSRKELELP 420
+ IE+ L +N + RP L+KH + + P E Q R Q D +K+ + E E
Sbjct: 263 QSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY- 321
Query: 421 ENIADSSCTGSTEESE 436
+GS EE E
Sbjct: 322 ------EYSGSEEEEE 331
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 122 bits (305), Expect = 9e-28
Identities = 96/316 (30%), Positives = 152/316 (48%), Gaps = 34/316 (10%)
Query: 142 DFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE-----IQACFRHENIAELYGA 196
+ + G +G+VY + +KT + A K++ V + +++ ++ H NIA YGA
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 197 VL------WGETVHLFMEAGEGGSVLEKLESC--GPMREFEIIWVTKHVLKGLDFLHSKK 248
+ + + L ME GSV + +++ ++E I ++ + +L+GL LH K
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHK 148
Query: 249 VIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILC-----R 302
VIH DIK N++ V LVDFG+S Q+ V GT +M+PEVI C
Sbjct: 149 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 GHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQ-APPLEDIADDCSPGM 361
+ K+D++SLG T I M G PP +P A L++I + AP L+ + S
Sbjct: 209 TYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA----LFLIPRNPAPRLK--SKKWSKKF 262
Query: 362 RELIEASLERNPNHRPRAADLLKHEAL-NPPREDQPRCQSLDSALLERKRLLSRKELELP 420
+ IE+ L +N + RP L+KH + + P E Q R Q D +K+ + E E
Sbjct: 263 QSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY- 321
Query: 421 ENIADSSCTGSTEESE 436
+GS EE E
Sbjct: 322 ------EYSGSEEEEE 331
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 122 bits (305), Expect = 9e-28
Identities = 96/316 (30%), Positives = 152/316 (48%), Gaps = 34/316 (10%)
Query: 142 DFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE-----IQACFRHENIAELYGA 196
+ + G +G+VY + +KT + A K++ V + +++ ++ H NIA YGA
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 197 VL------WGETVHLFMEAGEGGSVLEKLESC--GPMREFEIIWVTKHVLKGLDFLHSKK 248
+ + + L ME GSV + +++ ++E I ++ + +L+GL LH K
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHK 148
Query: 249 VIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILC-----R 302
VIH DIK N++ V LVDFG+S Q+ V GT +M+PEVI C
Sbjct: 149 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 GHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQ-APPLEDIADDCSPGM 361
+ K+D++SLG T I M G PP +P A L++I + AP L+ + S
Sbjct: 209 TYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA----LFLIPRNPAPRLK--SKKWSKKF 262
Query: 362 RELIEASLERNPNHRPRAADLLKHEAL-NPPREDQPRCQSLDSALLERKRLLSRKELELP 420
+ IE+ L +N + RP L+KH + + P E Q R Q D +K+ + E E
Sbjct: 263 QSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY- 321
Query: 421 ENIADSSCTGSTEESE 436
+GS EE E
Sbjct: 322 ------EYSGSEEEEE 331
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 122 bits (305), Expect = 9e-28
Identities = 96/316 (30%), Positives = 152/316 (48%), Gaps = 34/316 (10%)
Query: 142 DFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE-----IQACFRHENIAELYGA 196
+ + G +G+VY + +KT + A K++ V + +++ ++ H NIA YGA
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 197 VL------WGETVHLFMEAGEGGSVLEKLESC--GPMREFEIIWVTKHVLKGLDFLHSKK 248
+ + + L ME GSV + +++ ++E I ++ + +L+GL LH K
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHK 148
Query: 249 VIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILC-----R 302
VIH DIK N++ V LVDFG+S Q+ V GT +M+PEVI C
Sbjct: 149 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 GHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQ-APPLEDIADDCSPGM 361
+ K+D++SLG T I M G PP +P A L++I + AP L+ + S
Sbjct: 209 TYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA----LFLIPRNPAPRLK--SKKWSKKF 262
Query: 362 RELIEASLERNPNHRPRAADLLKHEAL-NPPREDQPRCQSLDSALLERKRLLSRKELELP 420
+ IE+ L +N + RP L+KH + + P E Q R Q D +K+ + E E
Sbjct: 263 QSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY- 321
Query: 421 ENIADSSCTGSTEESE 436
+GS EE E
Sbjct: 322 ------EYSGSEEEEE 331
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 122 bits (305), Expect = 9e-28
Identities = 96/316 (30%), Positives = 152/316 (48%), Gaps = 34/316 (10%)
Query: 142 DFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE-----IQACFRHENIAELYGA 196
+ + G +G+VY + +KT + A K++ V + +++ ++ H NIA YGA
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 197 VL------WGETVHLFMEAGEGGSVLEKLESC--GPMREFEIIWVTKHVLKGLDFLHSKK 248
+ + + L ME GSV + +++ ++E I ++ + +L+GL LH K
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHK 148
Query: 249 VIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILC-----R 302
VIH DIK N++ V LVDFG+S Q+ V GT +M+PEVI C
Sbjct: 149 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 GHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQ-APPLEDIADDCSPGM 361
+ K+D++SLG T I M G PP +P A L++I + AP L+ + S
Sbjct: 209 TYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA----LFLIPRNPAPRLK--SKKWSKKF 262
Query: 362 RELIEASLERNPNHRPRAADLLKHEAL-NPPREDQPRCQSLDSALLERKRLLSRKELELP 420
+ IE+ L +N + RP L+KH + + P E Q R Q D +K+ + E E
Sbjct: 263 QSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY- 321
Query: 421 ENIADSSCTGSTEESE 436
+GS EE E
Sbjct: 322 ------EYSGSEEEEE 331
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 122 bits (305), Expect = 9e-28
Identities = 96/316 (30%), Positives = 152/316 (48%), Gaps = 34/316 (10%)
Query: 142 DFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE-----IQACFRHENIAELYGA 196
+ + G +G+VY + +KT + A K++ V + +++ ++ H NIA YGA
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 197 VL------WGETVHLFMEAGEGGSVLEKLESC--GPMREFEIIWVTKHVLKGLDFLHSKK 248
+ + + L ME GSV + +++ ++E I ++ + +L+GL LH K
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHK 148
Query: 249 VIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILC-----R 302
VIH DIK N++ V LVDFG+S Q+ V GT +M+PEVI C
Sbjct: 149 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 GHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQ-APPLEDIADDCSPGM 361
+ K+D++SLG T I M G PP +P A L++I + AP L+ + S
Sbjct: 209 TYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA----LFLIPRNPAPRLK--SKKWSKKF 262
Query: 362 RELIEASLERNPNHRPRAADLLKHEAL-NPPREDQPRCQSLDSALLERKRLLSRKELELP 420
+ IE+ L +N + RP L+KH + + P E Q R Q D +K+ + E E
Sbjct: 263 QSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEY- 321
Query: 421 ENIADSSCTGSTEESE 436
+GS EE E
Sbjct: 322 ------EYSGSEEEEE 331
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 119 bits (299), Expect = 4e-27
Identities = 79/258 (30%), Positives = 124/258 (48%), Gaps = 23/258 (8%)
Query: 147 GAFGKVYLAQDIKTKKRMACKLIP-----------VDQFKPSDVEIQACFRHENIAELYG 195
GAF Y AQD+ T MA K + V + ++ + + H NI + G
Sbjct: 1252 GAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLG 1311
Query: 196 AVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIK 255
A +LF+E GGSV L G +E +I T+ +L+GL +LH ++IH D+K
Sbjct: 1312 ATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVK 1371
Query: 256 PSNIVFMST--KAVLVDFGLSVQM----TEDVYFPKDLRGTEIYMSPEVILCRGHSTKAD 309
+N++ ST + + DFG + ++ T F L GT +M+PEV+ + + D
Sbjct: 1372 GANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCD 1431
Query: 310 IYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHK--QAPPLEDIADDCSPGMRELIEA 367
++S+G +I M PPW + ++L +I K A I SPG+R++
Sbjct: 1432 VWSVGCAIIEMACAKPPW----NAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALR 1487
Query: 368 SLERNPNHRPRAADLLKH 385
LE P RP + +LLKH
Sbjct: 1488 CLELQPQDRPPSRELLKH 1505
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 118 bits (296), Expect = 1e-26
Identities = 94/320 (29%), Positives = 149/320 (46%), Gaps = 32/320 (10%)
Query: 142 DFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACF-----RHENIAELYGA 196
+ + G +G+VY + +KT + A K++ V + + +++++ H NIA YGA
Sbjct: 29 EVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGA 88
Query: 197 VL------WGETVHLFMEAGEGGSVLEKLESC--GPMREFEIIWVTKHVLKGLDFLHSKK 248
+ + + L ME GS+ + +++ ++E I ++++ +L+GL LH
Sbjct: 89 FIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHH 148
Query: 249 VIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILC-----R 302
VIH DIK N++ V LVDFG+S Q+ V GT +M+PEVI C
Sbjct: 149 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 GHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMR 362
+ ++D++S G T I M G PP +P A L++I + PP + S
Sbjct: 209 TYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRA----LFLIPRNPPPRLK-SKKWSKKFF 263
Query: 363 ELIEASLERNPNHRPRAADLLKHEAL-NPPREDQPRCQSLDSALLERKRLLSRKELELPE 421
IE L +N RP LLKH + + P E Q R Q D RK+ + E E
Sbjct: 264 SFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEY-- 321
Query: 422 NIADSSCTGSTEESEMLKRQ 441
+GS EE E + Q
Sbjct: 322 -----EYSGSEEEEEEVPEQ 336
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 118 bits (296), Expect = 1e-26
Identities = 94/320 (29%), Positives = 149/320 (46%), Gaps = 32/320 (10%)
Query: 142 DFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACF-----RHENIAELYGA 196
+ + G +G+VY + +KT + A K++ V + + +++++ H NIA YGA
Sbjct: 29 EVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGA 88
Query: 197 VL------WGETVHLFMEAGEGGSVLEKLESC--GPMREFEIIWVTKHVLKGLDFLHSKK 248
+ + + L ME GS+ + +++ ++E I ++++ +L+GL LH
Sbjct: 89 FIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHH 148
Query: 249 VIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILC-----R 302
VIH DIK N++ V LVDFG+S Q+ V GT +M+PEVI C
Sbjct: 149 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 GHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMR 362
+ ++D++S G T I M G PP +P A L++I + PP + S
Sbjct: 209 TYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRA----LFLIPRNPPPRLK-SKKWSKKFF 263
Query: 363 ELIEASLERNPNHRPRAADLLKHEAL-NPPREDQPRCQSLDSALLERKRLLSRKELELPE 421
IE L +N RP LLKH + + P E Q R Q D RK+ + E E
Sbjct: 264 SFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEY-- 321
Query: 422 NIADSSCTGSTEESEMLKRQ 441
+GS EE E + Q
Sbjct: 322 -----EYSGSEEEEEEVPEQ 336
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 118 bits (296), Expect = 1e-26
Identities = 94/320 (29%), Positives = 149/320 (46%), Gaps = 32/320 (10%)
Query: 142 DFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACF-----RHENIAELYGA 196
+ + G +G+VY + +KT + A K++ V + + +++++ H NIA YGA
Sbjct: 29 EVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGA 88
Query: 197 VL------WGETVHLFMEAGEGGSVLEKLESC--GPMREFEIIWVTKHVLKGLDFLHSKK 248
+ + + L ME GS+ + +++ ++E I ++++ +L+GL LH
Sbjct: 89 FIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHH 148
Query: 249 VIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILC-----R 302
VIH DIK N++ V LVDFG+S Q+ V GT +M+PEVI C
Sbjct: 149 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 GHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMR 362
+ ++D++S G T I M G PP +P A L++I + PP + S
Sbjct: 209 TYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRA----LFLIPRNPPPRLK-SKKWSKKFF 263
Query: 363 ELIEASLERNPNHRPRAADLLKHEAL-NPPREDQPRCQSLDSALLERKRLLSRKELELPE 421
IE L +N RP LLKH + + P E Q R Q D RK+ + E E
Sbjct: 264 SFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEY-- 321
Query: 422 NIADSSCTGSTEESEMLKRQ 441
+GS EE E + Q
Sbjct: 322 -----EYSGSEEEEEEVPEQ 336
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 117 bits (294), Expect = 2e-26
Identities = 94/293 (32%), Positives = 146/293 (49%), Gaps = 29/293 (9%)
Query: 134 LTYRNIGSDF-----IPRGAFGKVYLAQDIKTKKRMACKLI---PVDQFKPSDVEI---Q 182
L+ RN DF I G +G VY A+++ T + A K+I P + F EI +
Sbjct: 7 LSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMK 66
Query: 183 ACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLD 242
C +H NI +G+ L + + + ME GGS+ + GP+ E +I +V++ L+GL
Sbjct: 67 DC-KHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLY 125
Query: 243 FLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILC 301
+LHSK +H DIK +NI+ V L DFG+S Q+T + K GT +M+PEV
Sbjct: 126 YLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAV 185
Query: 302 R---GHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHK---QAPPLEDIAD 355
G++ D++++G T I + PP +P A L+++ K Q P L+D
Sbjct: 186 ERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRA----LFLMTKSNFQPPKLKD-KM 240
Query: 356 DCSPGMRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLER 408
S ++ +L +NP RP A LL+H P Q +SL LL++
Sbjct: 241 KWSNSFHHFVKMALTKNPKKRPTAEKLLQH-----PFVTQHLTRSLAIELLDK 288
>gi|191252782 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 117 bits (294), Expect = 2e-26
Identities = 81/251 (32%), Positives = 137/251 (54%), Gaps = 11/251 (4%)
Query: 144 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKP-----SDVEIQACFRHENIAELYGAVL 198
I G+ G V LA++ + +++A K++ + + + ++V I ++H N+ E+Y + L
Sbjct: 413 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYL 472
Query: 199 WGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSN 258
GE + + ME +GG++ + + S + E +I V + VL+ L +LH++ VIH DIK +
Sbjct: 473 VGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDS 531
Query: 259 IVF-MSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATL 317
I+ + + L DFG Q+++DV K L GT +M+PEVI ++T+ DI+SLG +
Sbjct: 532 ILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMV 591
Query: 318 IHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRP 377
I M G PP+ P A + + PP + SP +R+ +E L R+P R
Sbjct: 592 IEMVDGEPPYFSDSPVQA----MKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERA 647
Query: 378 RAADLLKHEAL 388
A +LL H L
Sbjct: 648 TAQELLDHPFL 658
>gi|191252780 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 117 bits (294), Expect = 2e-26
Identities = 81/251 (32%), Positives = 137/251 (54%), Gaps = 11/251 (4%)
Query: 144 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKP-----SDVEIQACFRHENIAELYGAVL 198
I G+ G V LA++ + +++A K++ + + + ++V I ++H N+ E+Y + L
Sbjct: 413 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYL 472
Query: 199 WGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSN 258
GE + + ME +GG++ + + S + E +I V + VL+ L +LH++ VIH DIK +
Sbjct: 473 VGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDS 531
Query: 259 IVF-MSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATL 317
I+ + + L DFG Q+++DV K L GT +M+PEVI ++T+ DI+SLG +
Sbjct: 532 ILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMV 591
Query: 318 IHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRP 377
I M G PP+ P A + + PP + SP +R+ +E L R+P R
Sbjct: 592 IEMVDGEPPYFSDSPVQA----MKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERA 647
Query: 378 RAADLLKHEAL 388
A +LL H L
Sbjct: 648 TAQELLDHPFL 658
>gi|9910476 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 117 bits (294), Expect = 2e-26
Identities = 81/251 (32%), Positives = 137/251 (54%), Gaps = 11/251 (4%)
Query: 144 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKP-----SDVEIQACFRHENIAELYGAVL 198
I G+ G V LA++ + +++A K++ + + + ++V I ++H N+ E+Y + L
Sbjct: 413 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYL 472
Query: 199 WGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSN 258
GE + + ME +GG++ + + S + E +I V + VL+ L +LH++ VIH DIK +
Sbjct: 473 VGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDS 531
Query: 259 IVF-MSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATL 317
I+ + + L DFG Q+++DV K L GT +M+PEVI ++T+ DI+SLG +
Sbjct: 532 ILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMV 591
Query: 318 IHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRP 377
I M G PP+ P A + + PP + SP +R+ +E L R+P R
Sbjct: 592 IEMVDGEPPYFSDSPVQA----MKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERA 647
Query: 378 RAADLLKHEAL 388
A +LL H L
Sbjct: 648 TAQELLDHPFL 658
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 117 bits (292), Expect = 3e-26
Identities = 84/252 (33%), Positives = 125/252 (49%), Gaps = 13/252 (5%)
Query: 144 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACF-----RHENIAELYGAVL 198
I +GA G VY A DI T + +A K + + Q ++ I ++ NI + L
Sbjct: 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 348
Query: 199 WGETVHLFMEAGEGGSVLEKL-ESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPS 257
G+ + + ME GGS+ + + E+C M E +I V + L+ LDFLHS +VIH DIK
Sbjct: 349 VGDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSD 406
Query: 258 NIVF-MSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGAT 316
NI+ M L DFG Q+T + + GT +M+PEV+ + + K DI+SLG
Sbjct: 407 NILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIM 466
Query: 317 LIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHR 376
I M G PP++ P A LY+I P + S R+ + LE + + R
Sbjct: 467 AIEMVEGEPPYLNENPLRA----LYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRR 522
Query: 377 PRAADLLKHEAL 388
A +LL+H L
Sbjct: 523 GSAKELLQHPFL 534
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 117 bits (292), Expect = 3e-26
Identities = 84/252 (33%), Positives = 125/252 (49%), Gaps = 13/252 (5%)
Query: 144 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACF-----RHENIAELYGAVL 198
I +GA G VY A DI T + +A K + + Q ++ I ++ NI + L
Sbjct: 295 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 354
Query: 199 WGETVHLFMEAGEGGSVLEKL-ESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPS 257
G+ + + ME GGS+ + + E+C M E +I V + L+ LDFLHS +VIH DIK
Sbjct: 355 VGDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSD 412
Query: 258 NIVF-MSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGAT 316
NI+ M L DFG Q+T + + GT +M+PEV+ + + K DI+SLG
Sbjct: 413 NILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIM 472
Query: 317 LIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHR 376
I M G PP++ P A LY+I P + S R+ + LE + + R
Sbjct: 473 AIEMVEGEPPYLNENPLRA----LYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRR 528
Query: 377 PRAADLLKHEAL 388
A +LL+H L
Sbjct: 529 GSAKELLQHPFL 540
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 117 bits (292), Expect = 3e-26
Identities = 84/252 (33%), Positives = 125/252 (49%), Gaps = 13/252 (5%)
Query: 144 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACF-----RHENIAELYGAVL 198
I +GA G VY A DI T + +A K + + Q ++ I ++ NI + L
Sbjct: 310 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 369
Query: 199 WGETVHLFMEAGEGGSVLEKL-ESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPS 257
G+ + + ME GGS+ + + E+C M E +I V + L+ LDFLHS +VIH DIK
Sbjct: 370 VGDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSD 427
Query: 258 NIVF-MSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGAT 316
NI+ M L DFG Q+T + + GT +M+PEV+ + + K DI+SLG
Sbjct: 428 NILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIM 487
Query: 317 LIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHR 376
I M G PP++ P A LY+I P + S R+ + LE + + R
Sbjct: 488 AIEMVEGEPPYLNENPLRA----LYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRR 543
Query: 377 PRAADLLKHEAL 388
A +LL+H L
Sbjct: 544 GSAKELLQHPFL 555
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 117 bits (292), Expect = 3e-26
Identities = 84/252 (33%), Positives = 125/252 (49%), Gaps = 13/252 (5%)
Query: 144 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACF-----RHENIAELYGAVL 198
I +GA G VY A DI T + +A K + + Q ++ I ++ NI + L
Sbjct: 274 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 333
Query: 199 WGETVHLFMEAGEGGSVLEKL-ESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPS 257
G+ + + ME GGS+ + + E+C M E +I V + L+ LDFLHS +VIH DIK
Sbjct: 334 VGDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSD 391
Query: 258 NIVF-MSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGAT 316
NI+ M L DFG Q+T + + GT +M+PEV+ + + K DI+SLG
Sbjct: 392 NILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIM 451
Query: 317 LIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHR 376
I M G PP++ P A LY+I P + S R+ + LE + + R
Sbjct: 452 AIEMVEGEPPYLNENPLRA----LYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRR 507
Query: 377 PRAADLLKHEAL 388
A +LL+H L
Sbjct: 508 GSAKELLQHPFL 519
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 117 bits (292), Expect = 3e-26
Identities = 84/252 (33%), Positives = 125/252 (49%), Gaps = 13/252 (5%)
Query: 144 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACF-----RHENIAELYGAVL 198
I +GA G VY A DI T + +A K + + Q ++ I ++ NI + L
Sbjct: 274 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 333
Query: 199 WGETVHLFMEAGEGGSVLEKL-ESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPS 257
G+ + + ME GGS+ + + E+C M E +I V + L+ LDFLHS +VIH DIK
Sbjct: 334 VGDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSD 391
Query: 258 NIVF-MSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGAT 316
NI+ M L DFG Q+T + + GT +M+PEV+ + + K DI+SLG
Sbjct: 392 NILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIM 451
Query: 317 LIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHR 376
I M G PP++ P A LY+I P + S R+ + LE + + R
Sbjct: 452 AIEMVEGEPPYLNENPLRA----LYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRR 507
Query: 377 PRAADLLKHEAL 388
A +LL+H L
Sbjct: 508 GSAKELLQHPFL 519
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 117 bits (292), Expect = 3e-26
Identities = 84/252 (33%), Positives = 125/252 (49%), Gaps = 13/252 (5%)
Query: 144 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACF-----RHENIAELYGAVL 198
I +GA G VY A DI T + +A K + + Q ++ I ++ NI + L
Sbjct: 274 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 333
Query: 199 WGETVHLFMEAGEGGSVLEKL-ESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPS 257
G+ + + ME GGS+ + + E+C M E +I V + L+ LDFLHS +VIH DIK
Sbjct: 334 VGDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSD 391
Query: 258 NIVF-MSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGAT 316
NI+ M L DFG Q+T + + GT +M+PEV+ + + K DI+SLG
Sbjct: 392 NILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIM 451
Query: 317 LIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHR 376
I M G PP++ P A LY+I P + S R+ + LE + + R
Sbjct: 452 AIEMVEGEPPYLNENPLRA----LYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRR 507
Query: 377 PRAADLLKHEAL 388
A +LL+H L
Sbjct: 508 GSAKELLQHPFL 519
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,680,199
Number of Sequences: 37866
Number of extensions: 849208
Number of successful extensions: 3633
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 498
Number of HSP's successfully gapped in prelim test: 274
Number of HSP's that attempted gapping in prelim test: 2050
Number of HSP's gapped (non-prelim): 910
length of query: 467
length of database: 18,247,518
effective HSP length: 106
effective length of query: 361
effective length of database: 14,233,722
effective search space: 5138373642
effective search space used: 5138373642
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.