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Search of human proteins with 114796630
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|114796630 homeodomain interacting protein kinase 3 isoform 2
[Homo sapiens]
(1194 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ... 2427 0.0
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ... 2415 0.0
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 1108 0.0
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 1096 0.0
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 960 0.0
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 865 0.0
gi|38201642 homeodomain-interacting protein kinase 1 isoform 3 [... 508 e-143
gi|38201644 homeodomain-interacting protein kinase 1 isoform 4 [... 455 e-127
gi|169171014 PREDICTED: similar to homeodomain interacting prote... 436 e-122
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] 322 1e-87
gi|169171552 PREDICTED: similar to homeodomain interacting prote... 228 3e-59
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 215 2e-55
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 215 2e-55
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 215 2e-55
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 215 2e-55
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 215 2e-55
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 208 3e-53
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 206 1e-52
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 204 3e-52
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 204 5e-52
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 200 8e-51
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 200 8e-51
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 188 2e-47
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 188 2e-47
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 171 5e-42
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 162 1e-39
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 162 1e-39
gi|10190706 CDC-like kinase 4 [Homo sapiens] 158 3e-38
gi|47717134 CDC-like kinase 2 [Homo sapiens] 152 1e-36
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 142 1e-33
>gi|114796630 homeodomain interacting protein kinase 3 isoform 2 [Homo
sapiens]
Length = 1194
Score = 2427 bits (6290), Expect = 0.0
Identities = 1194/1194 (100%), Positives = 1194/1194 (100%)
Query: 1 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGS 60
MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGS
Sbjct: 1 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGS 60
Query: 61 AFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLE 120
AFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLE
Sbjct: 61 AFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLE 120
Query: 121 GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEG 180
GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEG
Sbjct: 121 GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEG 180
Query: 181 DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI 240
DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI
Sbjct: 181 DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI 240
Query: 241 EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR 300
EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR
Sbjct: 241 EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR 300
Query: 301 PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL 360
PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL
Sbjct: 301 PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL 360
Query: 361 QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE 420
QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE
Sbjct: 361 QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE 420
Query: 421 QLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTV 480
QLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTV
Sbjct: 421 QLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTV 480
Query: 481 MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK 540
MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK
Sbjct: 481 MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK 540
Query: 541 SCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSV 600
SCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSV
Sbjct: 541 SCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSV 600
Query: 601 VHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPA 660
VHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPA
Sbjct: 601 VHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPA 660
Query: 661 VQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISC 720
VQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISC
Sbjct: 661 VQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISC 720
Query: 721 SNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRSNSLQNTNIPH 780
SNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRSNSLQNTNIPH
Sbjct: 721 SNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRSNSLQNTNIPH 780
Query: 781 SAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSDKQRQTIIIAD 840
SAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSDKQRQTIIIAD
Sbjct: 781 SAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSDKQRQTIIIAD 840
Query: 841 SPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTS 900
SPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTS
Sbjct: 841 SPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTS 900
Query: 901 SSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVEDTHENTELVS 960
SSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVEDTHENTELVS
Sbjct: 901 SSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVEDTHENTELVS 960
Query: 961 SADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQPLIKGRSAPGRLNQPSAVGTRQ 1020
SADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQPLIKGRSAPGRLNQPSAVGTRQ
Sbjct: 961 SADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQPLIKGRSAPGRLNQPSAVGTRQ 1020
Query: 1021 QKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTA 1080
QKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTA
Sbjct: 1021 QKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTA 1080
Query: 1081 VHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIV 1140
VHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIV
Sbjct: 1081 VHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIV 1140
Query: 1141 HQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM 1194
HQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM
Sbjct: 1141 HQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM 1194
>gi|114796624 homeodomain interacting protein kinase 3 isoform 1 [Homo
sapiens]
Length = 1215
Score = 2415 bits (6258), Expect = 0.0
Identities = 1194/1215 (98%), Positives = 1194/1215 (98%), Gaps = 21/1215 (1%)
Query: 1 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGS 60
MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGS
Sbjct: 1 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGS 60
Query: 61 AFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLE 120
AFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLE
Sbjct: 61 AFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLE 120
Query: 121 GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEG 180
GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEG
Sbjct: 121 GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEG 180
Query: 181 DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI 240
DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI
Sbjct: 181 DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI 240
Query: 241 EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR 300
EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR
Sbjct: 241 EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR 300
Query: 301 PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL 360
PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL
Sbjct: 301 PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL 360
Query: 361 QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE 420
QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE
Sbjct: 361 QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE 420
Query: 421 QLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTV 480
QLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTV
Sbjct: 421 QLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTV 480
Query: 481 MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK 540
MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK
Sbjct: 481 MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK 540
Query: 541 SCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSV 600
SCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSV
Sbjct: 541 SCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSV 600
Query: 601 VHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPA 660
VHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPA
Sbjct: 601 VHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPA 660
Query: 661 VQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISC 720
VQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISC
Sbjct: 661 VQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISC 720
Query: 721 SNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNR----------- 769
SNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNR
Sbjct: 721 SNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWEP 780
Query: 770 ----------SNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETS 819
SNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETS
Sbjct: 781 GREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETS 840
Query: 820 IRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQ 879
IRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQ
Sbjct: 841 IRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQ 900
Query: 880 STLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGH 939
STLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGH
Sbjct: 901 STLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGH 960
Query: 940 DSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQP 999
DSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQP
Sbjct: 961 DSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQP 1020
Query: 1000 LIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAY 1059
LIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAY
Sbjct: 1021 LIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAY 1080
Query: 1060 IPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASP 1119
IPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASP
Sbjct: 1081 IPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASP 1140
Query: 1120 CTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYT 1179
CTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYT
Sbjct: 1141 CTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYT 1200
Query: 1180 GFPLSPTKLSQYPYM 1194
GFPLSPTKLSQYPYM
Sbjct: 1201 GFPLSPTKLSQYPYM 1215
>gi|164420691 homeodomain interacting protein kinase 2 isoform 2 [Homo
sapiens]
Length = 1171
Score = 1108 bits (2866), Expect = 0.0
Identities = 646/1240 (52%), Positives = 794/1240 (64%), Gaps = 122/1240 (9%)
Query: 1 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC--VFQERNYPRTYVNGRNFGNSHPPTK 58
MAS V V+ P+ Q SSAFCSVKKLK+EPSS + ++ + Y +N S P T
Sbjct: 8 MASHVQVFSPHTLQ--SSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPAT- 64
Query: 59 GSAFQTKIPFNRPRGHNFSLQ-TSAVVLKNTAGATKVIAAQAQQAHVQA---PQIGAWRN 114
+ T +P P SL +V + G V +A + Q P R+
Sbjct: 65 -TTVSTSLPVPNP-----SLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRS 118
Query: 115 RLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTG---S 171
+ L+ Q+CGLKRKSEE++N SS +QI++E P M+Q N TV TATT S
Sbjct: 119 TVSLLDTYQKCGLKRKSEEIENTSS-VQIIEEH---PPMIQNNASG-ATVATATTSTATS 173
Query: 172 KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 231
K + + EGDYQLVQHEVLCSM NTYEVL+FLGRGTFGQVVKCWKRGTNEIVAIKILKNH
Sbjct: 174 KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 233
Query: 232 PSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKF 291
PSYARQGQIEVSILARLSTE+AD+YNFVRAYECFQH+NHTCLVFEMLEQNLYDFLKQNKF
Sbjct: 234 PSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
Query: 292 SPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 351
SPLPLK IRP+LQQVATAL KLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHV
Sbjct: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
Query: 352 SKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYI 411
SK VCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGA EYDQIRYI
Sbjct: 354 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYI 413
Query: 412 SQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSL 471
SQTQGLP E LL+ GTK+TRFF ++TD + WRLKT ++HEAETG+KSKEARKYIFN L
Sbjct: 414 SQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCL 473
Query: 472 DDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLL 531
DD+A VN DLEGSD+L EKADRREF+ LLKKML IDAD RITP ETLNHPFV M HLL
Sbjct: 474 DDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLL 533
Query: 532 DFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANF-TKIGTLRS 590
DFPHS HVKSCF M+ICK +N DT N +KT + VA S++ LT F ++ T+ +
Sbjct: 534 DFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHN 593
Query: 591 QALTTSAHSVVHHGIPLQAGTAQFGCG--DAFQQTLIICPPAIQGIPATHGKPTSYSIRV 648
Q S +V +PLQ GTAQ C D FQQ LI+CPP QG+ A+ K YS+R+
Sbjct: 594 QPSAASMAAVAQRSMPLQTGTAQI-CARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRM 652
Query: 649 DNTVPLVTQAPAVQPLQIRPGVLS-QTWSGRTQQMLV-PAWQQVTPLAPATT----TLTS 702
+N VP+VTQAP QPLQI+PG+L+ Q W TQQ+L+ PAWQQ+T +A T+ T+
Sbjct: 653 ENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIP 712
Query: 703 ESVAGSHRLGDWGKMISCSNHYNSVMPQP-LLTNQITLSAPQPVSVGIAHVVWPQPATTK 761
E++AG+ +L DW + +HYN +M QP LLT +TL A QP++VG+AHV+ QP +T
Sbjct: 713 ETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTT 772
Query: 762 KNKQCQNRSNSLQNTNI----PHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCE 817
+++ + +S++N + A SP+ K V+ E + + + C
Sbjct: 773 SSRKSKQHQSSVRNVSTCEVSSSQAISSPQ--RSKRVK-----ENTPPRCAMVHSSPACS 825
Query: 818 TSIR----QDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSL 873
TS+ + S+ ++QRQTI+I D+PSP VSVITISSDTDEEE Q+H
Sbjct: 826 TSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEE-EQKH--------- 875
Query: 874 DCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPT 933
+P ST+S +R N + SC TV SP
Sbjct: 876 ------------------APTSTVSK-----------QRKNVI-------SCVTVHDSPY 899
Query: 934 SDSSGHDSPFAESTFVEDTHENT-ELVSSADTETKPAVCSVVVPPVELENG--------- 983
SDSS + SP++ + N + S + +++VPP++ +
Sbjct: 900 SDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSL 959
Query: 984 --LNADEHMANTDSICQPLIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQH-LNFSQVQHF 1040
+N H ++ S + S + A+ RQQ+ FQQQ LN SQ Q
Sbjct: 960 VPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQ- 1018
Query: 1041 GSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHL---AGNTHLGGQPTL 1097
H + HRRQQAYI ++ P++ H SP+H VH HL A HL QP L
Sbjct: 1019 ---HITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHL 1075
Query: 1098 LPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTI 1157
Y + A L S VAHL+AS ++R +QH Y P+ IVHQVPV + PR+LPSPTI
Sbjct: 1076 YTYTAPAALGSTGTVAHLVASQGSARHTVQHTAY----PASIVHQVPVSMGPRVLPSPTI 1131
Query: 1158 HQTQYKPIFPPHSYIAASPA---YTGFPLSPTKLSQYPYM 1194
H +QY F +YI+ASPA YTG+PLSP K++QYPY+
Sbjct: 1132 HPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1171
>gi|164420685 homeodomain interacting protein kinase 2 isoform 1 [Homo
sapiens]
Length = 1198
Score = 1096 bits (2834), Expect = 0.0
Identities = 647/1267 (51%), Positives = 797/1267 (62%), Gaps = 149/1267 (11%)
Query: 1 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC--VFQERNYPRTYVNGRNFGNSHPPTK 58
MAS V V+ P+ Q SSAFCSVKKLK+EPSS + ++ + Y +N S P T
Sbjct: 8 MASHVQVFSPHTLQ--SSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPAT- 64
Query: 59 GSAFQTKIPFNRPRGHNFSLQ-TSAVVLKNTAGATKVIAAQAQQAHVQA---PQIGAWRN 114
+ T +P P SL +V + G V +A + Q P R+
Sbjct: 65 -TTVSTSLPVPNP-----SLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRS 118
Query: 115 RLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTG---S 171
+ L+ Q+CGLKRKSEE++N SS +QI++E P M+Q N TV TATT S
Sbjct: 119 TVSLLDTYQKCGLKRKSEEIENTSS-VQIIEEH---PPMIQNNASG-ATVATATTSTATS 173
Query: 172 KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 231
K + + EGDYQLVQHEVLCSM NTYEVL+FLGRGTFGQVVKCWKRGTNEIVAIKILKNH
Sbjct: 174 KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 233
Query: 232 PSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKF 291
PSYARQGQIEVSILARLSTE+AD+YNFVRAYECFQH+NHTCLVFEMLEQNLYDFLKQNKF
Sbjct: 234 PSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
Query: 292 SPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 351
SPLPLK IRP+LQQVATAL KLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHV
Sbjct: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
Query: 352 SKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYI 411
SK VCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGA EYDQIRYI
Sbjct: 354 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYI 413
Query: 412 SQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSL 471
SQTQGLP E LL+ GTK+TRFF ++TD + WRLKT ++HEAETG+KSKEARKYIFN L
Sbjct: 414 SQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCL 473
Query: 472 DDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLL 531
DD+A VN DLEGSD+L EKADRREF+ LLKKML IDAD RITP ETLNHPFV M HLL
Sbjct: 474 DDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLL 533
Query: 532 DFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANF-TKIGTLRS 590
DFPHS HVKSCF M+ICK +N DT N +KT + VA S++ LT F ++ T+ +
Sbjct: 534 DFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHN 593
Query: 591 QALTT---------------------------SAHSVVHHGIPLQAGTAQFGCG--DAFQ 621
QA ++ S +V +PLQ GTAQ C D FQ
Sbjct: 594 QAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQI-CARPDPFQ 652
Query: 622 QTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLS-QTWSGRTQ 680
Q LI+CPP QG+ A+ K YS+R++N VP+VTQAP QPLQI+PG+L+ Q W TQ
Sbjct: 653 QALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQ 712
Query: 681 QMLV-PAWQQVTPLAPATT----TLTSESVAGSHRLGDWGKMISCSNHYNSVMPQP-LLT 734
Q+L+ PAWQQ+T +A T+ T+ E++AG+ +L DW + +HYN +M QP LLT
Sbjct: 713 QILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLT 772
Query: 735 NQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRSNSLQNTNI----PHSAFISPKIIN 790
+TL A QP++VG+AHV+ QP +T +++ + +S++N + A SP+
Sbjct: 773 GHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQ--R 830
Query: 791 GKDVEEVSCIETQDNQNSEGEARNCCETSIR----QDSDSSVSDKQRQTIIIADSPSPAV 846
K V+ E + + + C TS+ + S+ ++QRQTI+I D+PSP V
Sbjct: 831 SKRVK-----ENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTV 885
Query: 847 SVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSS 906
SVITISSDTDEEE Q+H +P ST+S
Sbjct: 886 SVITISSDTDEEE-EQKH---------------------------APTSTVSK------- 910
Query: 907 PSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVEDTHENT-ELVSSADTE 965
+R N + SC TV SP SDSS + SP++ + N + S +
Sbjct: 911 ----QRKNVI-------SCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENH 959
Query: 966 TKPAVCSVVVPPVELENG-----------LNADEHMANTDSICQPLIKGRSAPGRLNQPS 1014
+++VPP++ + +N H ++ S + S +
Sbjct: 960 CTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSG 1019
Query: 1015 AVGTRQQKLTSAFQQQH-LNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSH 1073
A+ RQQ+ FQQQ LN SQ Q H + HRRQQAYI ++ P++ H
Sbjct: 1020 AITYRQQRPGPHFQQQQPLNLSQAQQ----HITTDRTGSHRRQQAYITPTMAQAPYSFPH 1075
Query: 1074 GSPNHTAVHAHL---AGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPT 1130
SP+H VH HL A HL QP L Y + A L S VAHL+AS ++R +QH
Sbjct: 1076 NSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTA 1135
Query: 1131 YNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPA---YTGFPLSPTK 1187
Y P+ IVHQVPV + PR+LPSPTIH +QY F +YI+ASPA YTG+PLSP K
Sbjct: 1136 Y----PASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAK 1191
Query: 1188 LSQYPYM 1194
++QYPY+
Sbjct: 1192 VNQYPYI 1198
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [Homo
sapiens]
Length = 1210
Score = 960 bits (2482), Expect = 0.0
Identities = 612/1306 (46%), Positives = 766/1306 (58%), Gaps = 208/1306 (15%)
Query: 1 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC-VFQERNYPRTYVNGRNFGNSHPPTKG 59
MASQ+ V+ P SSAFCS KKLK+EPS V + + + Y + + P T+G
Sbjct: 1 MASQLQVFSPP--SVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTL----PATQG 54
Query: 60 SAFQTK--IPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLH 117
A + FN P ++ L A +++ + A + Q+ Q R+ +
Sbjct: 55 QANSSHQVANFNIP-AYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVS 113
Query: 118 FLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTT 177
LE Q+CGLKRKSEE+D++ S +QI++E L +T +G T T TT K + ++
Sbjct: 114 LLEPYQKCGLKRKSEEVDSNGS-VQIIEEHPPLMLQNRTVVGAAATTTTVTT--KSSSSS 170
Query: 178 GEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQ 237
GEGDYQLVQHE+LCSM N+YEVL+FLGRGTFGQV KCWKR T EIVAIKILKNHPSYARQ
Sbjct: 171 GEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQ 230
Query: 238 GQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 297
GQIEVSIL+RLS+ENADEYNFVR+YECFQH+NHTCLVFEMLEQNLYDFLKQNKFSPLPLK
Sbjct: 231 GQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 290
Query: 298 VIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCS 357
IRPILQQVATAL KLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK VCS
Sbjct: 291 YIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCS 350
Query: 358 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGL 417
TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGA EYDQIRYISQTQGL
Sbjct: 351 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGL 410
Query: 418 PGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHV 477
P E LL+ GTK+TRFF ++ ++ + WRLKT EEHE ETG+KSKEARKYIFN LDD+A V
Sbjct: 411 PAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQV 470
Query: 478 NTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSN 537
N DLEG+D+LAEKADRRE++ LLKKML IDAD RITP +TLNH FV M HLLDFPHSN
Sbjct: 471 NMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSN 530
Query: 538 HVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFT-KIGTLRSQALTTS 596
HVKSCF M+ICK ++ DT + K+ VA +++ LT +F+ ++ T+ +QA +
Sbjct: 531 HVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLA 590
Query: 597 AHS---------------------------------VVHHGIPLQAGTAQFGCG-DAFQQ 622
+ S V G+ LQ GT Q D FQQ
Sbjct: 591 SSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQ 650
Query: 623 TLIICPPAIQ-GIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLS--------- 672
T I+CPPA Q G+ AT K + + +R+DN VP+V QAPA QPLQI+ GVL+
Sbjct: 651 TFIVCPPAFQTGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMV 709
Query: 673 -------------------------------------QTWSGRTQQMLVPA-WQQVTPLA 694
Q W G TQQ+L+P+ WQQ+ +A
Sbjct: 710 ATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVA 769
Query: 695 ----PATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQP-LLTNQITLSAPQPVSVGI 749
T + E++ +L DW S N Y+++M QP LLTN +TL+ QP++VG+
Sbjct: 770 LHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGV 829
Query: 750 AHVVWPQPAT---TKKNKQCQNRSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQ 806
AHVV Q ++ +KKNKQ SA +S K S ++ +Q
Sbjct: 830 AHVVRQQQSSSLPSKKNKQ---------------SAPVSSK----------SSLDVLPSQ 864
Query: 807 NSEGEARNCCETSIRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSL 866
+ T+ +S V D Q Q III D+PSP VSVITI SDTDEEE
Sbjct: 865 VYSLVGSSPLRTTSSYNSLVPVQD-QHQPIIIPDTPSPPVSVITIRSDTDEEE------- 916
Query: 867 RECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCD 926
D+ SSSG + S
Sbjct: 917 ---------------------------DNKYKPSSSG------------LKPRSNVISYV 937
Query: 927 TVDGSPTSDSSGHDSPFAESTFVE------DTHENTELVSSADTETKPAVCSVVVPPVEL 980
TV+ SP SDSS SP++ T E V + T T+ +++VPP++
Sbjct: 938 TVNDSPDSDSS-LSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGTR----TIIVPPLKT 992
Query: 981 ENG--LNADEHMANTDSICQPL--IKGRSAPGRLNQPSAVGTRQQK-LTSAFQQQHLNFS 1035
+ G A + + +P+ + G+S+ G P+ G R Q+ TSA Q +L+ +
Sbjct: 993 QLGDCTVATQASGLLSNKTKPVASVSGQSS-GCCITPT--GYRAQRGGTSAAQPLNLSQN 1049
Query: 1036 QVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLA-GNTHLGGQ 1094
Q QE + N RRQQA++ ++ P+T HGSP H+ H HLA HL Q
Sbjct: 1050 QQSSAAPTSQERSSNPAPRRQQAFV-APLSQAPYTFQHGSPLHSTGHPHLAPAPAHLPSQ 1108
Query: 1095 PTLLPY---PSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGLNPRL 1151
L Y S+A L S + +AHL + +SR H +HPS +VHQVPV + P L
Sbjct: 1109 AHLYTYAAPTSAAALGSTSSIAHLFSPQGSSR----HAAAYTTHPSTLVHQVPVSVGPSL 1164
Query: 1152 LPSPTIHQTQYKPIFPPHSYIAA---SPAYTGFPLSPTKLSQYPYM 1194
L S ++ QY+ F SYI + S YTG+PLSPTK+SQY Y+
Sbjct: 1165 LTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL 1210
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
[Homo sapiens]
Length = 1075
Score = 865 bits (2234), Expect = 0.0
Identities = 519/1009 (51%), Positives = 633/1009 (62%), Gaps = 133/1009 (13%)
Query: 1 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC-VFQERNYPRTYVNGRNFGNSHPPTKG 59
MASQ+ V+ P SSAFCS KKLK+EPS V + + + Y + + P T+G
Sbjct: 1 MASQLQVFSPP--SVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTL----PATQG 54
Query: 60 SAFQTK--IPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLH 117
A + FN P ++ L A +++ + A + Q+ Q R+ +
Sbjct: 55 QANSSHQVANFNIP-AYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVS 113
Query: 118 FLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTT 177
LE Q+CGLKRKSEE+D++ S +QI++E L +T +G T T TT K + ++
Sbjct: 114 LLEPYQKCGLKRKSEEVDSNGS-VQIIEEHPPLMLQNRTVVGAAATTTTVTT--KSSSSS 170
Query: 178 GEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQ 237
GEGDYQLVQHE+LCSM N+YEVL+FLGRGTFGQV KCWKR T EIVAIKILKNHPSYARQ
Sbjct: 171 GEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQ 230
Query: 238 GQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 297
GQIEVSIL+RLS+ENADEYNFVR+YECFQH+NHTCLVFEMLEQNLYDFLKQNKFSPLPLK
Sbjct: 231 GQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 290
Query: 298 VIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCS 357
IRPILQQVATAL KLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK VCS
Sbjct: 291 YIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCS 350
Query: 358 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGL 417
TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGA EYDQIRYISQTQGL
Sbjct: 351 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGL 410
Query: 418 PGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHV 477
P E LL+ GTK+TRFF ++ ++ + WRLKT EEHE ETG+KSKEARKYIFN LDD+A V
Sbjct: 411 PAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQV 470
Query: 478 NTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSN 537
N DLEG+D+LAEKADRRE++ LLKKML IDAD RITP +TLNH FV M HLLDFPHSN
Sbjct: 471 NMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSN 530
Query: 538 HVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFT-KIGTLRSQALTTS 596
HVKSCF M+ICK ++ DT + K+ VA +++ LT +F+ ++ T+ +QA +
Sbjct: 531 HVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLA 590
Query: 597 AHS---------------------------------VVHHGIPLQAGTAQFGCG-DAFQQ 622
+ S V G+ LQ GT Q D FQQ
Sbjct: 591 SSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQ 650
Query: 623 TLIICPPAIQ-GIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLS--------- 672
T I+CPPA Q G+ AT K + + +R+DN VP+V QAPA QPLQI+ GVL+
Sbjct: 651 TFIVCPPAFQTGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMV 709
Query: 673 -------------------------------------QTWSGRTQQMLVPA-WQQVTPLA 694
Q W G TQQ+L+P+ WQQ+ +A
Sbjct: 710 ATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVA 769
Query: 695 ----PATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQP-LLTNQITLSAPQPVSVGI 749
T + E++ +L DW S N Y+++M QP LLTN +TL+ QP++VG+
Sbjct: 770 LHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGV 829
Query: 750 AHVVWPQPAT---TKKNKQCQNRSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQ 806
AHVV Q ++ +KKNKQ SA +S K S ++ +Q
Sbjct: 830 AHVVRQQQSSSLPSKKNKQ---------------SAPVSSK----------SSLDVLPSQ 864
Query: 807 NSEGEARNCCETSIRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSL 866
+ T+ +S V D Q Q III D+PSP VSVITI SDTDEEE ++
Sbjct: 865 VYSLVGSSPLRTTSSYNSLVPVQD-QHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPS 923
Query: 867 RECKGSLDCEACQSTLN--IDRMCSLSSPDSTLSTSSSGQSSPSPCKRP 913
T+N D SLSSP ST + S+ +S S + P
Sbjct: 924 SSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGP 972
>gi|38201642 homeodomain-interacting protein kinase 1 isoform 3 [Homo
sapiens]
Length = 836
Score = 508 bits (1308), Expect = e-143
Identities = 363/922 (39%), Positives = 478/922 (51%), Gaps = 195/922 (21%)
Query: 382 MWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSH 441
MWSLGCVIAELFLGWPLYPGA EYDQIRYISQTQGLP E LL+ GTK+TRFF ++ ++ +
Sbjct: 1 MWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGY 60
Query: 442 SGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSL 501
WRLKT EEHE ETG+KSKEARKYIFN LDD+A VN DLEG+D+LAEKADRRE++ L
Sbjct: 61 PLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDL 120
Query: 502 LKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNSCDTNNH 561
LKKML IDAD RITP +TLNH FV M HLLDFPHSNHVKSCF M+ICK ++ DT +
Sbjct: 121 LKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQ 180
Query: 562 NKTSLLRPVASSSTATLTANFT-KIGTLRSQALTTSAHS--------------------- 599
K+ VA +++ LT +F+ ++ T+ +QA ++ S
Sbjct: 181 IKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQS 240
Query: 600 ------------VVHHGIPLQAGTAQFGCG-DAFQQTLIICPPAIQ-GIPATHGKPTSYS 645
V G+ LQ GT Q D FQQT I+CPPA Q G+ AT K + +
Sbjct: 241 ALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQAT-TKHSGFP 299
Query: 646 IRVDNTVPLVTQAPAVQPLQIRPGVLS--------------------------------- 672
+R+DN VP+V QAPA QPLQI+ GVL+
Sbjct: 300 VRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAA 359
Query: 673 -------------QTWSGRTQQMLVPA-WQQVTPLA----PATTTLTSESVAGSHRLGDW 714
Q W G TQQ+L+P+ WQQ+ +A T + E++ +L DW
Sbjct: 360 GRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADW 419
Query: 715 GKMISCSNHYNSVMPQP-LLTNQITLSAPQPVSVGIAHVVWPQPAT---TKKNKQCQNRS 770
S N Y+++M QP LLTN +TL+ QP++VG+AHVV Q ++ +KKNKQ
Sbjct: 420 RNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQ----- 474
Query: 771 NSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSD 830
SA +S K S ++ +Q + T+ +S V D
Sbjct: 475 ----------SAPVSSK----------SSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQD 514
Query: 831 KQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSL 890
Q Q III D+PSP VSVITI SDTDEEE
Sbjct: 515 -QHQPIIIPDTPSPPVSVITIRSDTDEEE------------------------------- 542
Query: 891 SSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVE 950
D+ SSSG + S TV+ SP SDSS SP++ T
Sbjct: 543 ---DNKYKPSSSG------------LKPRSNVISYVTVNDSPDSDSS-LSSPYSTDTLSA 586
Query: 951 ------DTHENTELVSSADTETKPAVCSVVVPPVELENG--LNADEHMANTDSICQPL-- 1000
E V + T T+ +++VPP++ + G A + + +P+
Sbjct: 587 LRGNSGSVLEGPGRVVADGTGTR----TIIVPPLKTQLGDCTVATQASGLLSNKTKPVAS 642
Query: 1001 IKGRSAPGRLNQPSAVGTRQQK-LTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAY 1059
+ G+S+ G P+ G R Q+ TSA Q +L+ +Q QE + N RRQQA+
Sbjct: 643 VSGQSS-GCCITPT--GYRAQRGGTSAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAF 699
Query: 1060 IPTSVTSNPFTLSHGSPNHTAVHAHLA-GNTHLGGQPTLLPY---PSSATLSSAAPVAHL 1115
+ ++ P+T HGSP H+ H HLA HL Q L Y S+A L S + +AHL
Sbjct: 700 V-APLSQAPYTFQHGSPLHSTGHPHLAPAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHL 758
Query: 1116 LASPCTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAA- 1174
+ +SR H +HPS +VHQVPV + P LL S ++ QY+ F SYI +
Sbjct: 759 FSPQGSSR----HAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSS 814
Query: 1175 --SPAYTGFPLSPTKLSQYPYM 1194
S YTG+PLSPTK+SQY Y+
Sbjct: 815 RGSTIYTGYPLSPTKISQYSYL 836
>gi|38201644 homeodomain-interacting protein kinase 1 isoform 4 [Homo
sapiens]
Length = 816
Score = 455 bits (1170), Expect = e-127
Identities = 339/897 (37%), Positives = 454/897 (50%), Gaps = 195/897 (21%)
Query: 407 QIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKY 466
QIRYISQTQGLP E LL+ GTK+TRFF ++ ++ + WRLKT EEHE ETG+KSKEARKY
Sbjct: 6 QIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKY 65
Query: 467 IFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVN 526
IFN LDD+A VN DLEG+D+LAEKADRRE++ LLKKML IDAD RITP +TLNH FV
Sbjct: 66 IFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVT 125
Query: 527 MKHLLDFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFT-KI 585
M HLLDFPHSNHVKSCF M+ICK ++ DT + K+ VA +++ LT +F+ ++
Sbjct: 126 MTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQL 185
Query: 586 GTLRSQALTTSAHS---------------------------------VVHHGIPLQAGTA 612
T+ +QA ++ S V G+ LQ GT
Sbjct: 186 NTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTT 245
Query: 613 QFGCG-DAFQQTLIICPPAIQ-GIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGV 670
Q D FQQT I+CPPA Q G+ AT K + + +R+DN VP+V QAPA QPLQI+ GV
Sbjct: 246 QICTQTDPFQQTFIVCPPAFQTGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGV 304
Query: 671 LS----------------------------------------------QTWSGRTQQMLV 684
L+ Q W G TQQ+L+
Sbjct: 305 LTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILL 364
Query: 685 PA-WQQVTPLA----PATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQP-LLTNQIT 738
P+ WQQ+ +A T + E++ +L DW S N Y+++M QP LLTN +T
Sbjct: 365 PSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVT 424
Query: 739 LSAPQPVSVGIAHVVWPQPAT---TKKNKQCQNRSNSLQNTNIPHSAFISPKIINGKDVE 795
L+ QP++VG+AHVV Q ++ +KKNKQ SA +S K
Sbjct: 425 LATAQPLNVGVAHVVRQQQSSSLPSKKNKQ---------------SAPVSSK-------- 461
Query: 796 EVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDT 855
S ++ +Q + T+ +S V D Q Q III D+PSP VSVITI SDT
Sbjct: 462 --SSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQD-QHQPIIIPDTPSPPVSVITIRSDT 518
Query: 856 DEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNS 915
DEEE D+ SSSG
Sbjct: 519 DEEE----------------------------------DNKYKPSSSG------------ 532
Query: 916 MSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVE------DTHENTELVSSADTETKPA 969
+ S TV+ SP SDSS SP++ T E V + T T+
Sbjct: 533 LKPRSNVISYVTVNDSPDSDSS-LSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGTR-- 589
Query: 970 VCSVVVPPVELENG--LNADEHMANTDSICQPL--IKGRSAPGRLNQPSAVGTRQQK-LT 1024
+++VPP++ + G A + + +P+ + G+S+ G P+ G R Q+ T
Sbjct: 590 --TIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQSS-GCCITPT--GYRAQRGGT 644
Query: 1025 SAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAH 1084
SA Q +L+ +Q QE + N RRQQA++ ++ P+T HGSP H+ H H
Sbjct: 645 SAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFV-APLSQAPYTFQHGSPLHSTGHPH 703
Query: 1085 LA-GNTHLGGQPTLLPY---PSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIV 1140
LA HL Q L Y S+A L S + +AHL + +SR H +HPS +V
Sbjct: 704 LAPAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQGSSR----HAAAYTTHPSTLV 759
Query: 1141 HQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAA---SPAYTGFPLSPTKLSQYPYM 1194
HQVPV + P LL S ++ QY+ F SYI + S YTG+PLSPTK+SQY Y+
Sbjct: 760 HQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL 816
>gi|169171014 PREDICTED: similar to homeodomain interacting protein
kinase 2 [Homo sapiens]
Length = 460
Score = 436 bits (1122), Expect = e-122
Identities = 246/375 (65%), Positives = 277/375 (73%), Gaps = 23/375 (6%)
Query: 1 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC--VFQERNYPRTYVNGRNFGNSHPPTK 58
MAS V V+ P+ Q SSAFCSVKKLK+EPSS + ++ + Y +N S P T
Sbjct: 8 MASHVQVFSPHTLQ--SSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPAT- 64
Query: 59 GSAFQTKIPFNRPRGHNFSLQ-TSAVVLKNTAGATKVIAAQAQQAHVQA---PQIGAWRN 114
+ T +P P SL +V + G V +A + Q P R+
Sbjct: 65 -TTVSTSLPVPNP-----SLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRS 118
Query: 115 RLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTG---S 171
+ L+ Q+CGLKRKSEE++N SS +QI++E P M+Q N TV TATT S
Sbjct: 119 TVSLLDTYQKCGLKRKSEEIENTSS-VQIIEEH---PPMIQNNASG-ATVATATTSTATS 173
Query: 172 KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 231
K + + EGDYQLVQHEVLCSM NTYEVL+FLGRGTFGQVVKCWKRGTNEIVAIKILKNH
Sbjct: 174 KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 233
Query: 232 PSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKF 291
PSYARQGQIEVSILARLSTE+AD+YNFVRAYECFQH+NHTCLVFEMLEQNLYDFLKQNKF
Sbjct: 234 PSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
Query: 292 SPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 351
SPLPLK IRP+LQQVATAL KLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHV
Sbjct: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
Query: 352 SKTVCSTYLQSRYYR 366
SK VCSTYLQSRYYR
Sbjct: 354 SKAVCSTYLQSRYYR 368
>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
Length = 616
Score = 322 bits (825), Expect = 1e-87
Identities = 172/355 (48%), Positives = 233/355 (65%), Gaps = 8/355 (2%)
Query: 192 SMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE 251
S + Y++++ LG+GTFG+V K W+R T E+VAIKILKN R + E+ +L +
Sbjct: 6 SETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGL 65
Query: 252 NADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALK 311
+ +E + +R E F LVFE+LEQNL++F K+N F+PLP + IR + QV TAL
Sbjct: 66 DPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALA 125
Query: 312 KLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKT--VCSTYLQSRYYRAPE 369
+LK L +IHADLKPENIMLVD R P+RVKVIDFGSAS S+ V Y+QSR+YRAPE
Sbjct: 126 RLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185
Query: 370 IILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKS 429
I+LGLPFCE +D+WSLGCV+AEL LGWPLYPG EYDQ+RYI +TQGLP LL+ K+
Sbjct: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245
Query: 430 TRFFCKETDMSHSG-WRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVN-----TVMDL 483
FF + + W+LK+ ++ AET ++ E RKY+ SLD + VN + +
Sbjct: 246 HHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTF 305
Query: 484 EGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNH 538
+ LAE AD + V L+K+ML ++ RI+P+ L HPFV+M+ L + H
Sbjct: 306 PDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360
>gi|169171552 PREDICTED: similar to homeodomain interacting protein
kinase 3 [Homo sapiens]
Length = 264
Score = 228 bits (580), Expect = 3e-59
Identities = 143/266 (53%), Positives = 172/266 (64%), Gaps = 23/266 (8%)
Query: 1 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC--VFQERNYPRTYVNGRNFGNSHPPTK 58
MAS V V+ P+ Q SSAFCSVKKLK+EPSS + ++ + Y +N S P T
Sbjct: 1 MASHVQVFSPHTLQ--SSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPAT- 57
Query: 59 GSAFQTKIPFNRPRGHNFSLQ-TSAVVLKNTAGATKVIAAQAQQAHVQA---PQIGAWRN 114
+ T +P P SL +V + G V +A + Q P R+
Sbjct: 58 -TTVSTSLPVPNP-----SLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRS 111
Query: 115 RLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTG---S 171
+ L+ Q+CGLKRKSEE++N SS +QI++E P M+Q N TV TATT S
Sbjct: 112 TVSLLDTYQKCGLKRKSEEIENTSS-VQIIEEH---PPMIQNNASG-ATVATATTSTATS 166
Query: 172 KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 231
K + + EGDYQLVQHEVLCSM NTYEVL+FLGRGTFGQVVKCWKRGTNEIVAIKILKNH
Sbjct: 167 KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 226
Query: 232 PSYARQGQIEVSILARLSTENADEYN 257
PSYARQGQIEVSILARLSTE+AD+YN
Sbjct: 227 PSYARQGQIEVSILARLSTESADDYN 252
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 215 bits (548), Expect = 2e-55
Identities = 133/335 (39%), Positives = 188/335 (56%), Gaps = 22/335 (6%)
Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ + + +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
Y V F RNH CLVFEML NLYD L+ F + L + R QQ+ TAL L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
Query: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335
Query: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
+P+ AIDMWSLGC++ E+ G PL+ GA E DQ+ I + G+P +L+ K+ +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395
Query: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK- 492
K D W LK ++ + E K RK L ++ V T G E
Sbjct: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-----LHNILGVET--GGPGGRRAGESG 443
Query: 493 ---ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
AD +F L+ +ML D RI P L H F
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 478
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 215 bits (548), Expect = 2e-55
Identities = 133/335 (39%), Positives = 188/335 (56%), Gaps = 22/335 (6%)
Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ + + +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
Y V F RNH CLVFEML NLYD L+ F + L + R QQ+ TAL L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
Query: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335
Query: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
+P+ AIDMWSLGC++ E+ G PL+ GA E DQ+ I + G+P +L+ K+ +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395
Query: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK- 492
K D W LK ++ + E K RK L ++ V T G E
Sbjct: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-----LHNILGVET--GGPGGRRAGESG 443
Query: 493 ---ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
AD +F L+ +ML D RI P L H F
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 478
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 215 bits (548), Expect = 2e-55
Identities = 133/335 (39%), Positives = 188/335 (56%), Gaps = 22/335 (6%)
Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ + + +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
Y V F RNH CLVFEML NLYD L+ F + L + R QQ+ TAL L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
Query: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335
Query: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
+P+ AIDMWSLGC++ E+ G PL+ GA E DQ+ I + G+P +L+ K+ +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395
Query: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK- 492
K D W LK ++ + E K RK L ++ V T G E
Sbjct: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-----LHNILGVET--GGPGGRRAGESG 443
Query: 493 ---ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
AD +F L+ +ML D RI P L H F
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 478
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 215 bits (548), Expect = 2e-55
Identities = 133/335 (39%), Positives = 188/335 (56%), Gaps = 22/335 (6%)
Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ + + +
Sbjct: 150 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 209
Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
Y V F RNH CLVFEML NLYD L+ F + L + R QQ+ TAL L +
Sbjct: 210 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 269
Query: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 270 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 326
Query: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
+P+ AIDMWSLGC++ E+ G PL+ GA E DQ+ I + G+P +L+ K+ +FF
Sbjct: 327 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 386
Query: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK- 492
K D W LK ++ + E K RK L ++ V T G E
Sbjct: 387 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-----LHNILGVET--GGPGGRRAGESG 434
Query: 493 ---ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
AD +F L+ +ML D RI P L H F
Sbjct: 435 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 469
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 215 bits (548), Expect = 2e-55
Identities = 133/335 (39%), Positives = 188/335 (56%), Gaps = 22/335 (6%)
Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
YE+ +G+G+FGQVVK + R E VAIKI+KN ++ Q QIEV +L ++ + + +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218
Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
Y V F RNH CLVFEML NLYD L+ F + L + R QQ+ TAL L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278
Query: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335
Query: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
+P+ AIDMWSLGC++ E+ G PL+ GA E DQ+ I + G+P +L+ K+ +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395
Query: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK- 492
K D W LK ++ + E K RK L ++ V T G E
Sbjct: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-----LHNILGVET--GGPGGRRAGESG 443
Query: 493 ---ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
AD +F L+ +ML D RI P L H F
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 478
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 208 bits (529), Expect = 3e-53
Identities = 127/339 (37%), Positives = 189/339 (55%), Gaps = 30/339 (8%)
Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
YE+ +G+G+FGQVVK + T E+VAIKI+KN ++ Q QIE+ +L ++ + + +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
Y V F RNH CLVFE+L NLYD L+ F + L + R + QQ+ TAL L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Query: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
Query: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
P+ AIDMWSLGC++ E+ G PL+ G+ E DQ+ I + G+P +L+ K+ ++F
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
Query: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYI----FNSLDDVAHVNTVMDLEGSDLL 489
+ + GW L+ ++KE RK L +V V T G
Sbjct: 348 ER---LPGGGWTLR-----------RTKELRKDYQGPGTRRLQEVLGVQT--GGPGGRRA 391
Query: 490 AEK----ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
E AD F L+ +ML + RI+P L H F
Sbjct: 392 GEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGF 430
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 206 bits (523), Expect = 1e-52
Identities = 122/331 (36%), Positives = 184/331 (55%), Gaps = 42/331 (12%)
Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
YE+ +G+G+FGQVVK + T E+VAIKI+KN ++ Q QIE+ +L ++ + + +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
Y V F RNH CLVFE+L NLYD L+ F + L + R + QQ+ TAL L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Query: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
Query: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
P+ AIDMWSLGC++ E+ G PL+ G+ E DQ+ I + G+P +L+ K+ ++F
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
Query: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKA 493
+ + GW L+ ++KE RK D +G
Sbjct: 348 ER---LPGGGWTLR-----------RTKELRK----------------DYQG------PG 371
Query: 494 DRREFVSLLKKMLLIDADLRITPAETLNHPF 524
RR L+ +ML + RI+P L H F
Sbjct: 372 TRRLQEDLVLRMLEYEPAARISPLGALQHGF 402
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 204 bits (520), Expect = 3e-52
Identities = 106/258 (41%), Positives = 162/258 (62%), Gaps = 9/258 (3%)
Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
YE+ +G+G+FGQVVK + T E+VAIKI+KN ++ Q QIE+ +L ++ + + +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
Y V F RNH CLVFE+L NLYD L+ F + L + R + QQ+ TAL L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Query: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
L +IH DLKPENI+L +P R +K++DFGS+ + + + Y+QSR+YR+PE++LG
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287
Query: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
P+ AIDMWSLGC++ E+ G PL+ G+ E DQ+ I + G+P +L+ K+ ++F
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
Query: 434 CKETDMSHSGWRLKTLEE 451
+ + GW L+ +E
Sbjct: 348 ER---LPGGGWTLRRTKE 362
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 204 bits (518), Expect = 5e-52
Identities = 128/362 (35%), Positives = 189/362 (52%), Gaps = 37/362 (10%)
Query: 171 SKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKN 230
SK + G Y V H+ + YEVL+ +G+G+FGQV KC NE+VA+KI++N
Sbjct: 81 SKTSFDDEHGFYLKVLHDHIAYR---YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRN 137
Query: 231 HPSYARQGQIEVSILARLSTENADE-YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQN 289
+ +Q +E+ IL L ++ D YN V + F RNH C+ FE+L NLY+ +K N
Sbjct: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197
Query: 290 KFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSAS 349
F L ++R V L+ L +IH DLKPENI+L + VKVIDFGS+
Sbjct: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ--KGQASVKVIDFGSSC 255
Query: 350 HVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIR 409
+ + V TY+QSR+YR+PE+ILG P+ AIDMWSLGC+ AEL+ G+PL+PG E +Q+
Sbjct: 256 YEHQKVY-TYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLA 314
Query: 410 YISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFN 469
I + GLP + ++ FF SK K I N
Sbjct: 315 CIMEVLGLPPAGFIQTASRRQTFF-------------------------DSKGFPKNITN 349
Query: 470 SLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKH 529
+ + ++ DL + K F+ L++ L+ + LR+TP + L H +++
Sbjct: 350 NRGKKRYPDS-KDL----TMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSR 404
Query: 530 LL 531
L
Sbjct: 405 NL 406
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 200 bits (508), Expect = 8e-51
Identities = 124/359 (34%), Positives = 188/359 (52%), Gaps = 36/359 (10%)
Query: 179 EGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 238
+G Y V H+ + YEVL +G+G+FGQVVK + ++ VA+K+++N + RQ
Sbjct: 207 QGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQA 263
Query: 239 QIEVSILARLSTENADE-YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 297
E+ IL L ++ D N + E F RNH C+ FE+L NLY+ +K+NKF L
Sbjct: 264 AEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLP 323
Query: 298 VIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCS 357
++R + L L +IH DLKPENI+L R +KVIDFGS+ + + V
Sbjct: 324 LVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDFGSSCYEHQRVY- 380
Query: 358 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGL 417
TY+QSR+YRAPE+ILG + IDMWSLGC++AEL G+PL PG E DQ+ + + G+
Sbjct: 381 TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGM 440
Query: 418 PGEQLLNVGTKSTRF--------FCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFN 469
P ++LL+ ++ F +C T +S L + E+R++
Sbjct: 441 PSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKL-RGPPESREW--- 496
Query: 470 SLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMK 528
G+ L + D F+ LK+ L D +R+TP + L HP++ +
Sbjct: 497 ---------------GNAL--KGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR 538
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 200 bits (508), Expect = 8e-51
Identities = 124/359 (34%), Positives = 188/359 (52%), Gaps = 36/359 (10%)
Query: 179 EGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 238
+G Y V H+ + YEVL +G+G+FGQVVK + ++ VA+K+++N + RQ
Sbjct: 134 QGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQA 190
Query: 239 QIEVSILARLSTENADE-YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 297
E+ IL L ++ D N + E F RNH C+ FE+L NLY+ +K+NKF L
Sbjct: 191 AEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLP 250
Query: 298 VIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCS 357
++R + L L +IH DLKPENI+L R +KVIDFGS+ + + V
Sbjct: 251 LVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDFGSSCYEHQRVY- 307
Query: 358 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGL 417
TY+QSR+YRAPE+ILG + IDMWSLGC++AEL G+PL PG E DQ+ + + G+
Sbjct: 308 TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGM 367
Query: 418 PGEQLLNVGTKSTRF--------FCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFN 469
P ++LL+ ++ F +C T +S L + E+R++
Sbjct: 368 PSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKL-RGPPESREW--- 423
Query: 470 SLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMK 528
G+ L + D F+ LK+ L D +R+TP + L HP++ +
Sbjct: 424 ---------------GNAL--KGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR 465
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 188 bits (478), Expect = 2e-47
Identities = 114/331 (34%), Positives = 174/331 (52%), Gaps = 17/331 (5%)
Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTEN-ADE 255
YEVL +G+G+FGQV + + + VA+K+++N + RQ E+ IL L ++
Sbjct: 189 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 248
Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
N + E F RNH C+ FE+L +LY+ +K+NKF ++++R Q + +L L
Sbjct: 249 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 308
Query: 316 LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLP 375
+IH DLKPENI+L R KVIDFGS+ + + TY+QSR+YRAPEIILG
Sbjct: 309 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGSR 365
Query: 376 FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCK 435
+ ID+WS GC++AEL G PL+PG E DQ+ + + G+P +LL +K ++F
Sbjct: 366 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE-QSKRAKYFIN 424
Query: 436 ETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADR 495
+ + G +S+ +K D L+G D
Sbjct: 425 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA-----LKG-------CDD 472
Query: 496 REFVSLLKKMLLIDADLRITPAETLNHPFVN 526
F+ LK+ L D R+TPA+ L HP+++
Sbjct: 473 YLFIEFLKRCLHWDPSARLTPAQALRHPWIS 503
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 188 bits (478), Expect = 2e-47
Identities = 114/331 (34%), Positives = 174/331 (52%), Gaps = 17/331 (5%)
Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTEN-ADE 255
YEVL +G+G+FGQV + + + VA+K+++N + RQ E+ IL L ++
Sbjct: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268
Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
N + E F RNH C+ FE+L +LY+ +K+NKF ++++R Q + +L L
Sbjct: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328
Query: 316 LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLP 375
+IH DLKPENI+L R KVIDFGS+ + + TY+QSR+YRAPEIILG
Sbjct: 329 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGSR 385
Query: 376 FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCK 435
+ ID+WS GC++AEL G PL+PG E DQ+ + + G+P +LL +K ++F
Sbjct: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE-QSKRAKYFIN 444
Query: 436 ETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADR 495
+ + G +S+ +K D L+G D
Sbjct: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA-----LKG-------CDD 492
Query: 496 REFVSLLKKMLLIDADLRITPAETLNHPFVN 526
F+ LK+ L D R+TPA+ L HP+++
Sbjct: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 171 bits (432), Expect = 5e-42
Identities = 115/362 (31%), Positives = 186/362 (51%), Gaps = 25/362 (6%)
Query: 172 KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRG-TNEIVAIKILKN 230
+ N T EG Y++ EVL Y V + G+G F VV+ N+ VA+KI++N
Sbjct: 665 RDNWTDAEGYYRVNIGEVL---DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRN 721
Query: 231 HPSYARQGQIEVSILARLSTENADE-YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ- 288
+ + G E+ L +L+ + D+ ++ +R + F H+ H CLVFE L NL + LK+
Sbjct: 722 NELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKY 781
Query: 289 NKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSA 348
K L +K +R QQ+ ALK LK ++HAD+KP+NI++ + +K+ DFGSA
Sbjct: 782 GKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNE---SKTILKLCDFGSA 838
Query: 349 SHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQI 408
SHV+ + YL SR+YRAPEII+G + IDMWS+GC + EL+ G L+PG +
Sbjct: 839 SHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHML 898
Query: 409 RYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIF 468
+ +G +++ G + F + +++ + + E E T M + K
Sbjct: 899 KLAMDLKGKMPNKMIRKGVFKDQHF--DQNLNFMYIEVDKVTEREKVTVMSTINPTK--- 953
Query: 469 NSLDDVAHVNTVMDLEGSDLLAEKADRR--EFVSLLKKMLLIDADLRITPAETLNHPFVN 526
+ + DL G L E ++ + LL ++L++D RI+ + L H F+
Sbjct: 954 ---------DLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQ 1004
Query: 527 MK 528
K
Sbjct: 1005 EK 1006
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 162 bits (411), Expect = 1e-39
Identities = 106/348 (30%), Positives = 174/348 (50%), Gaps = 46/348 (13%)
Query: 197 YEVLDFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADE 255
YE++D LG G FG+VV+C + VA+KI+KN Y + E+ +L L+T + +
Sbjct: 203 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 262
Query: 256 -YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLK 314
+ V+ E F+H H C+VFE+L + YDF+K+N F P L IR + Q+ ++ L
Sbjct: 263 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 322
Query: 315 SLGLIHADLKPENIMLVD---------PVRQPYR------VKVIDFGSASHVSKTVCSTY 359
S L H DLKPENI+ V +++ R +KV+DFGSA++ + ST
Sbjct: 323 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 381
Query: 360 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPG 419
+ +R+YRAPE+IL L + + D+WS+GC++ E +LG+ ++P + + + + G
Sbjct: 382 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 441
Query: 420 EQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNT 479
+ ++ K F D W +EH + A +Y+ +
Sbjct: 442 KHMIQKTRKRKYFHHDRLD-----W-----DEHSS--------AGRYVSRRCKPLKEF-- 481
Query: 480 VMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNM 527
+L++ + L++KML D RIT E L HPF ++
Sbjct: 482 --------MLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDL 521
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 162 bits (411), Expect = 1e-39
Identities = 106/348 (30%), Positives = 174/348 (50%), Gaps = 46/348 (13%)
Query: 197 YEVLDFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADE 255
YE++D LG G FG+VV+C + VA+KI+KN Y + E+ +L L+T + +
Sbjct: 161 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 220
Query: 256 -YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLK 314
+ V+ E F+H H C+VFE+L + YDF+K+N F P L IR + Q+ ++ L
Sbjct: 221 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 280
Query: 315 SLGLIHADLKPENIMLVD---------PVRQPYR------VKVIDFGSASHVSKTVCSTY 359
S L H DLKPENI+ V +++ R +KV+DFGSA++ + ST
Sbjct: 281 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 339
Query: 360 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPG 419
+ +R+YRAPE+IL L + + D+WS+GC++ E +LG+ ++P + + + + G
Sbjct: 340 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 399
Query: 420 EQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNT 479
+ ++ K F D W +EH + A +Y+ +
Sbjct: 400 KHMIQKTRKRKYFHHDRLD-----W-----DEHSS--------AGRYVSRRCKPLKEF-- 439
Query: 480 VMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNM 527
+L++ + L++KML D RIT E L HPF ++
Sbjct: 440 --------MLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDL 479
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 158 bits (400), Expect = 3e-38
Identities = 104/352 (29%), Positives = 174/352 (49%), Gaps = 46/352 (13%)
Query: 193 MKNTYEVLDFLGRGTFGQVVKCWKRGTNEI-VAIKILKNHPSYARQGQIEVSILARL-ST 250
++ YE++D LG G FG+VV+C G + + VA+KI+KN Y + E+ +L L ST
Sbjct: 155 LRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNST 214
Query: 251 ENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATAL 310
+ + V+ E F H H C+VFE+L + YDF+K+N F P + IR + Q+ ++
Sbjct: 215 DPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSI 274
Query: 311 KKLKSLGLIHADLKPENIMLV---------DPVRQPYR------VKVIDFGSASHVSKTV 355
L L H DLKPENI+ V +++ R +KV+DFGSA++ +
Sbjct: 275 NFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEH- 333
Query: 356 CSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQ 415
ST + +R+YRAPE+IL L + + D+WS+GC++ E +LG+ ++ + + + +
Sbjct: 334 HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERIL 393
Query: 416 GLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVA 475
G + ++ K F + D W +EH + A +Y+ +
Sbjct: 394 GPIPQHMIQKTRKRKYFHHNQLD-----W-----DEHSS--------AGRYVRRRCKPLK 435
Query: 476 HVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNM 527
+L + + L+++ML D RIT E L HPF ++
Sbjct: 436 EF----------MLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDL 477
>gi|47717134 CDC-like kinase 2 [Homo sapiens]
Length = 498
Score = 152 bits (385), Expect = 1e-36
Identities = 100/350 (28%), Positives = 172/350 (49%), Gaps = 48/350 (13%)
Query: 193 MKNTYEVLDFLGRGTFGQVVKC--WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST 250
++ YE++ LG GTFG+VV+C +RG VA+KI+KN Y ++E+++L +++
Sbjct: 158 LQERYEIVSTLGEGTFGRVVQCVDHRRGGAR-VALKIIKNVEKYKEAARLEINVLEKINE 216
Query: 251 ENADEYNF-VRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATA 309
++ D N V+ ++ F + H C+ FE+L + +DFLK N + P P+ +R + Q+ A
Sbjct: 217 KDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQA 276
Query: 310 LKKLKSLGLIHADLKPENIMLVDPVRQ---------------PYRVKVIDFGSASHVSKT 354
+K L L H DLKPENI+ V+ + V+V+DFGSA+
Sbjct: 277 VKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT-FDHE 335
Query: 355 VCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQT 414
ST + +R+YRAPE+IL L + + D+WS+GC+I E ++G+ L+ + + + +
Sbjct: 336 HHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERI 395
Query: 415 QGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDV 474
G +++ K F+ D + + + E+ K R+Y
Sbjct: 396 LGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVREN-------CKPLRRY-------- 440
Query: 475 AHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
L +E + + L++ ML + R+T E L HPF
Sbjct: 441 -------------LTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPF 477
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 142 bits (359), Expect = 1e-33
Identities = 100/352 (28%), Positives = 174/352 (49%), Gaps = 52/352 (14%)
Query: 193 MKNTYEVLDFLGRGTFGQVVKCWK--RGTNEIVAIKILKNHPSYARQGQIEVSILARLST 250
++ YE++ LG GTFG+VV+C RG ++ VA+KI++N Y ++E+++L ++
Sbjct: 300 LQERYEIVGNLGEGTFGKVVECLDHARGKSQ-VALKIIRNVGKYREAARLEINVLKKIKE 358
Query: 251 ENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATA 309
++ + ++ V + F H C+ FE+L +N ++FLK+N F P PL +R + Q+ A
Sbjct: 359 KDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHA 418
Query: 310 LKKLKSLGLIHADLKPENIMLVDPVRQPY---------------RVKVIDFGSAS--HVS 352
L+ L L H DLKPENI+ V+ + ++V DFGSA+ H
Sbjct: 419 LRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEH 478
Query: 353 KTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYIS 412
T T + +R+YR PE+IL L + + D+WS+GC++ E + G+ L+ + + +
Sbjct: 479 HT---TIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMME 535
Query: 413 QTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLD 472
+ G +++ T+ ++F K + + + G KE K +
Sbjct: 536 KILGPIPSHMIH-RTRKQKYFYKG----------GLVWDENSSDGRYVKENCKPL----- 579
Query: 473 DVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
S +L + + + L+++ML D RIT AE L HPF
Sbjct: 580 ------------KSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPF 619
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.129 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,550,603
Number of Sequences: 37866
Number of extensions: 2386840
Number of successful extensions: 10978
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 435
Number of HSP's successfully gapped in prelim test: 484
Number of HSP's that attempted gapping in prelim test: 8056
Number of HSP's gapped (non-prelim): 2064
length of query: 1194
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1080
effective length of database: 13,930,794
effective search space: 15045257520
effective search space used: 15045257520
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.