Search of human proteins with 114796624

Search of human proteins with 114796624

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|114796624 homeodomain interacting protein kinase 3 isoform 1
[Homo sapiens]
         (1215 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ...  2472   0.0  
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ...  2415   0.0  
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ...  1100   0.0  
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ...  1088   0.0  
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [...   952   0.0  
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [...   857   0.0  
gi|38201642 homeodomain-interacting protein kinase 1 isoform 3 [...   500   e-141
gi|38201644 homeodomain-interacting protein kinase 1 isoform 4 [...   447   e-125
gi|169171014 PREDICTED: similar to homeodomain interacting prote...   436   e-122
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]   322   1e-87
gi|169171552 PREDICTED: similar to homeodomain interacting prote...   228   3e-59
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula...   215   2e-55
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula...   215   2e-55
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula...   215   2e-55
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula...   215   2e-55
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula...   215   2e-55
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat...   208   3e-53
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat...   206   1e-52
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat...   204   3e-52
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula...   204   5e-52
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul...   200   8e-51
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat...   200   8e-51
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula...   188   2e-47
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula...   188   2e-47
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]      171   5e-42
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]               162   1e-39
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]                162   1e-39
gi|10190706 CDC-like kinase 4 [Homo sapiens]                          158   3e-38
gi|47717134 CDC-like kinase 2 [Homo sapiens]                          152   1e-36
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]               142   1e-33

>gi|114796624 homeodomain interacting protein kinase 3 isoform 1 [Homo
            sapiens]
          Length = 1215

 Score = 2472 bits (6406), Expect = 0.0
 Identities = 1215/1215 (100%), Positives = 1215/1215 (100%)

Query: 1    MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGS 60
            MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGS
Sbjct: 1    MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGS 60

Query: 61   AFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLE 120
            AFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLE
Sbjct: 61   AFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLE 120

Query: 121  GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEG 180
            GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEG
Sbjct: 121  GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEG 180

Query: 181  DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI 240
            DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI
Sbjct: 181  DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI 240

Query: 241  EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR 300
            EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR
Sbjct: 241  EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR 300

Query: 301  PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL 360
            PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL
Sbjct: 301  PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL 360

Query: 361  QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE 420
            QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE
Sbjct: 361  QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE 420

Query: 421  QLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTV 480
            QLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTV
Sbjct: 421  QLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTV 480

Query: 481  MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK 540
            MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK
Sbjct: 481  MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK 540

Query: 541  SCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSV 600
            SCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSV
Sbjct: 541  SCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSV 600

Query: 601  VHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPA 660
            VHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPA
Sbjct: 601  VHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPA 660

Query: 661  VQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISC 720
            VQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISC
Sbjct: 661  VQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISC 720

Query: 721  SNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWEP 780
            SNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWEP
Sbjct: 721  SNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWEP 780

Query: 781  GREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETS 840
            GREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETS
Sbjct: 781  GREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETS 840

Query: 841  IRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQ 900
            IRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQ
Sbjct: 841  IRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQ 900

Query: 901  STLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGH 960
            STLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGH
Sbjct: 901  STLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGH 960

Query: 961  DSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQP 1020
            DSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQP
Sbjct: 961  DSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQP 1020

Query: 1021 LIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAY 1080
            LIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAY
Sbjct: 1021 LIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAY 1080

Query: 1081 IPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASP 1140
            IPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASP
Sbjct: 1081 IPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASP 1140

Query: 1141 CTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYT 1200
            CTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYT
Sbjct: 1141 CTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYT 1200

Query: 1201 GFPLSPTKLSQYPYM 1215
            GFPLSPTKLSQYPYM
Sbjct: 1201 GFPLSPTKLSQYPYM 1215


>gi|114796630 homeodomain interacting protein kinase 3 isoform 2 [Homo
            sapiens]
          Length = 1194

 Score = 2415 bits (6258), Expect = 0.0
 Identities = 1194/1215 (98%), Positives = 1194/1215 (98%), Gaps = 21/1215 (1%)

Query: 1    MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGS 60
            MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGS
Sbjct: 1    MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGS 60

Query: 61   AFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLE 120
            AFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLE
Sbjct: 61   AFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLE 120

Query: 121  GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEG 180
            GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEG
Sbjct: 121  GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEG 180

Query: 181  DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI 240
            DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI
Sbjct: 181  DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI 240

Query: 241  EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR 300
            EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR
Sbjct: 241  EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR 300

Query: 301  PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL 360
            PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL
Sbjct: 301  PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL 360

Query: 361  QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE 420
            QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE
Sbjct: 361  QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE 420

Query: 421  QLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTV 480
            QLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTV
Sbjct: 421  QLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTV 480

Query: 481  MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK 540
            MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK
Sbjct: 481  MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK 540

Query: 541  SCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSV 600
            SCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSV
Sbjct: 541  SCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSV 600

Query: 601  VHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPA 660
            VHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPA
Sbjct: 601  VHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPA 660

Query: 661  VQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISC 720
            VQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISC
Sbjct: 661  VQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISC 720

Query: 721  SNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWEP 780
            SNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNR           
Sbjct: 721  SNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNR----------- 769

Query: 781  GREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETS 840
                      SNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETS
Sbjct: 770  ----------SNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETS 819

Query: 841  IRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQ 900
            IRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQ
Sbjct: 820  IRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQ 879

Query: 901  STLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGH 960
            STLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGH
Sbjct: 880  STLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGH 939

Query: 961  DSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQP 1020
            DSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQP
Sbjct: 940  DSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQP 999

Query: 1021 LIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAY 1080
            LIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAY
Sbjct: 1000 LIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAY 1059

Query: 1081 IPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASP 1140
            IPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASP
Sbjct: 1060 IPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASP 1119

Query: 1141 CTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYT 1200
            CTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYT
Sbjct: 1120 CTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYT 1179

Query: 1201 GFPLSPTKLSQYPYM 1215
            GFPLSPTKLSQYPYM
Sbjct: 1180 GFPLSPTKLSQYPYM 1194


>gi|164420691 homeodomain interacting protein kinase 2 isoform 2 [Homo
            sapiens]
          Length = 1171

 Score = 1100 bits (2845), Expect = 0.0
 Identities = 648/1260 (51%), Positives = 793/1260 (62%), Gaps = 141/1260 (11%)

Query: 1    MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC--VFQERNYPRTYVNGRNFGNSHPPTK 58
            MAS V V+ P+  Q  SSAFCSVKKLK+EPSS   +    ++ + Y   +N   S P T 
Sbjct: 8    MASHVQVFSPHTLQ--SSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPAT- 64

Query: 59   GSAFQTKIPFNRPRGHNFSLQ-TSAVVLKNTAGATKVIAAQAQQAHVQA---PQIGAWRN 114
             +   T +P   P     SL     +V   + G   V +A +     Q    P     R+
Sbjct: 65   -TTVSTSLPVPNP-----SLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRS 118

Query: 115  RLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTG---S 171
             +  L+  Q+CGLKRKSEE++N SS +QI++E    P M+Q N     TV TATT    S
Sbjct: 119  TVSLLDTYQKCGLKRKSEEIENTSS-VQIIEEH---PPMIQNNASG-ATVATATTSTATS 173

Query: 172  KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 231
            K + +  EGDYQLVQHEVLCSM NTYEVL+FLGRGTFGQVVKCWKRGTNEIVAIKILKNH
Sbjct: 174  KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 233

Query: 232  PSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKF 291
            PSYARQGQIEVSILARLSTE+AD+YNFVRAYECFQH+NHTCLVFEMLEQNLYDFLKQNKF
Sbjct: 234  PSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293

Query: 292  SPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 351
            SPLPLK IRP+LQQVATAL KLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHV
Sbjct: 294  SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353

Query: 352  SKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYI 411
            SK VCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGA EYDQIRYI
Sbjct: 354  SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYI 413

Query: 412  SQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSL 471
            SQTQGLP E LL+ GTK+TRFF ++TD  +  WRLKT ++HEAETG+KSKEARKYIFN L
Sbjct: 414  SQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCL 473

Query: 472  DDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLL 531
            DD+A VN   DLEGSD+L EKADRREF+ LLKKML IDAD RITP ETLNHPFV M HLL
Sbjct: 474  DDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLL 533

Query: 532  DFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANF-TKIGTLRS 590
            DFPHS HVKSCF  M+ICK  +N  DT N +KT  +  VA S++  LT  F  ++ T+ +
Sbjct: 534  DFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHN 593

Query: 591  QALTTSAHSVVHHGIPLQAGTAQFGCG--DAFQQTLIICPPAIQGIPATHGKPTSYSIRV 648
            Q    S  +V    +PLQ GTAQ  C   D FQQ LI+CPP  QG+ A+  K   YS+R+
Sbjct: 594  QPSAASMAAVAQRSMPLQTGTAQI-CARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRM 652

Query: 649  DNTVPLVTQAPAVQPLQIRPGVLS-QTWSGRTQQMLV-PAWQQVTPLAPATT----TLTS 702
            +N VP+VTQAP  QPLQI+PG+L+ Q W   TQQ+L+ PAWQQ+T +A  T+    T+  
Sbjct: 653  ENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIP 712

Query: 703  ESVAGSHRLGDWGKMISCSNHYNSVMPQP-LLTNQITLSAPQPVSVGIAHVVWPQPATT- 760
            E++AG+ +L DW    +  +HYN +M QP LLT  +TL A QP++VG+AHV+  QP +T 
Sbjct: 713  ETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTT 772

Query: 761  --KKNKQCQNRGILVKLMEWEPGREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEV 818
              +K+KQ Q+    V   E     + I++   S  ++    P  A +             
Sbjct: 773  SSRKSKQHQSSVRNVSTCE-VSSSQAISSPQRSKRVKENTPPRCAMV------------- 818

Query: 819  SCIETQDNQNSEGEARNCCETSIR----QDSDSSVSDKQRQTIIIADSPSPAVSVITISS 874
                          +   C TS+       + S+  ++QRQTI+I D+PSP VSVITISS
Sbjct: 819  -------------HSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISS 865

Query: 875  DTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRP 934
            DTDEEE  Q+H                           +P ST+S            +R 
Sbjct: 866  DTDEEE-EQKH---------------------------APTSTVSK-----------QRK 886

Query: 935  NSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVEDTHENT-ELVSSADTETKPAVCS 993
            N +       SC TV  SP SDSS + SP++        + N  +   S +        +
Sbjct: 887  NVI-------SCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRT 939

Query: 994  VVVPPVELENG-----------LNADEHMANTDSICQPLIKGRSAPGRLNQPSAVGTRQQ 1042
            ++VPP++ +             +N   H ++  S     +   S     +   A+  RQQ
Sbjct: 940  IIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQ 999

Query: 1043 KLTSAFQQQH-LNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTA 1101
            +    FQQQ  LN SQ Q     H   +    HRRQQAYI  ++   P++  H SP+H  
Sbjct: 1000 RPGPHFQQQQPLNLSQAQQ----HITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGT 1055

Query: 1102 VHAHL---AGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPS 1158
            VH HL   A   HL  QP L  Y + A L S   VAHL+AS  ++R  +QH  Y    P+
Sbjct: 1056 VHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAY----PA 1111

Query: 1159 GIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPA---YTGFPLSPTKLSQYPYM 1215
             IVHQVPV + PR+LPSPTIH +QY   F   +YI+ASPA   YTG+PLSP K++QYPY+
Sbjct: 1112 SIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1171


>gi|164420685 homeodomain interacting protein kinase 2 isoform 1 [Homo
            sapiens]
          Length = 1198

 Score = 1088 bits (2813), Expect = 0.0
 Identities = 649/1287 (50%), Positives = 796/1287 (61%), Gaps = 168/1287 (13%)

Query: 1    MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC--VFQERNYPRTYVNGRNFGNSHPPTK 58
            MAS V V+ P+  Q  SSAFCSVKKLK+EPSS   +    ++ + Y   +N   S P T 
Sbjct: 8    MASHVQVFSPHTLQ--SSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPAT- 64

Query: 59   GSAFQTKIPFNRPRGHNFSLQ-TSAVVLKNTAGATKVIAAQAQQAHVQA---PQIGAWRN 114
             +   T +P   P     SL     +V   + G   V +A +     Q    P     R+
Sbjct: 65   -TTVSTSLPVPNP-----SLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRS 118

Query: 115  RLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTG---S 171
             +  L+  Q+CGLKRKSEE++N SS +QI++E    P M+Q N     TV TATT    S
Sbjct: 119  TVSLLDTYQKCGLKRKSEEIENTSS-VQIIEEH---PPMIQNNASG-ATVATATTSTATS 173

Query: 172  KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 231
            K + +  EGDYQLVQHEVLCSM NTYEVL+FLGRGTFGQVVKCWKRGTNEIVAIKILKNH
Sbjct: 174  KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 233

Query: 232  PSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKF 291
            PSYARQGQIEVSILARLSTE+AD+YNFVRAYECFQH+NHTCLVFEMLEQNLYDFLKQNKF
Sbjct: 234  PSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293

Query: 292  SPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 351
            SPLPLK IRP+LQQVATAL KLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHV
Sbjct: 294  SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353

Query: 352  SKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYI 411
            SK VCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGA EYDQIRYI
Sbjct: 354  SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYI 413

Query: 412  SQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSL 471
            SQTQGLP E LL+ GTK+TRFF ++TD  +  WRLKT ++HEAETG+KSKEARKYIFN L
Sbjct: 414  SQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCL 473

Query: 472  DDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLL 531
            DD+A VN   DLEGSD+L EKADRREF+ LLKKML IDAD RITP ETLNHPFV M HLL
Sbjct: 474  DDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLL 533

Query: 532  DFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANF-TKIGTLRS 590
            DFPHS HVKSCF  M+ICK  +N  DT N +KT  +  VA S++  LT  F  ++ T+ +
Sbjct: 534  DFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHN 593

Query: 591  QALTT---------------------------SAHSVVHHGIPLQAGTAQFGCG--DAFQ 621
            QA ++                           S  +V    +PLQ GTAQ  C   D FQ
Sbjct: 594  QAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQI-CARPDPFQ 652

Query: 622  QTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLS-QTWSGRTQ 680
            Q LI+CPP  QG+ A+  K   YS+R++N VP+VTQAP  QPLQI+PG+L+ Q W   TQ
Sbjct: 653  QALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQ 712

Query: 681  QMLV-PAWQQVTPLAPATT----TLTSESVAGSHRLGDWGKMISCSNHYNSVMPQP-LLT 734
            Q+L+ PAWQQ+T +A  T+    T+  E++AG+ +L DW    +  +HYN +M QP LLT
Sbjct: 713  QILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLT 772

Query: 735  NQITLSAPQPVSVGIAHVVWPQPATT---KKNKQCQNRGILVKLMEWEPGREEINAFSWS 791
              +TL A QP++VG+AHV+  QP +T   +K+KQ Q+    V   E     + I++   S
Sbjct: 773  GHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCE-VSSSQAISSPQRS 831

Query: 792  NSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIR----QDSDS 847
              ++    P  A +                           +   C TS+       + S
Sbjct: 832  KRVKENTPPRCAMV--------------------------HSSPACSTSVTCGWGDVASS 865

Query: 848  SVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDR 907
            +  ++QRQTI+I D+PSP VSVITISSDTDEEE  Q+H                      
Sbjct: 866  TTRERQRQTIVIPDTPSPTVSVITISSDTDEEE-EQKH---------------------- 902

Query: 908  MCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAES 967
                 +P ST+S            +R N +       SC TV  SP SDSS + SP++  
Sbjct: 903  -----APTSTVSK-----------QRKNVI-------SCVTVHDSPYSDSSSNTSPYSVQ 939

Query: 968  TFVEDTHENT-ELVSSADTETKPAVCSVVVPPVELENG-----------LNADEHMANTD 1015
                  + N  +   S +        +++VPP++ +             +N   H ++  
Sbjct: 940  QRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYK 999

Query: 1016 SICQPLIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQH-LNFSQVQHFGSGHQEWNGNFGH 1074
            S     +   S     +   A+  RQQ+    FQQQ  LN SQ Q     H   +    H
Sbjct: 1000 SKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQ----HITTDRTGSH 1055

Query: 1075 RRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHL---AGNTHLGGQPTLLPYPSSATLSSAA 1131
            RRQQAYI  ++   P++  H SP+H  VH HL   A   HL  QP L  Y + A L S  
Sbjct: 1056 RRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTG 1115

Query: 1132 PVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHS 1191
             VAHL+AS  ++R  +QH  Y    P+ IVHQVPV + PR+LPSPTIH +QY   F   +
Sbjct: 1116 TVAHLVASQGSARHTVQHTAY----PASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQT 1171

Query: 1192 YIAASPA---YTGFPLSPTKLSQYPYM 1215
            YI+ASPA   YTG+PLSP K++QYPY+
Sbjct: 1172 YISASPASTVYTGYPLSPAKVNQYPYI 1198


>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [Homo
            sapiens]
          Length = 1210

 Score =  952 bits (2461), Expect = 0.0
 Identities = 612/1327 (46%), Positives = 766/1327 (57%), Gaps = 229/1327 (17%)

Query: 1    MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC-VFQERNYPRTYVNGRNFGNSHPPTKG 59
            MASQ+ V+ P      SSAFCS KKLK+EPS   V  + +  + Y + +      P T+G
Sbjct: 1    MASQLQVFSPP--SVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTL----PATQG 54

Query: 60   SAFQTK--IPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLH 117
             A  +     FN P  ++  L   A  +++        +  A  +  Q+ Q    R+ + 
Sbjct: 55   QANSSHQVANFNIP-AYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVS 113

Query: 118  FLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTT 177
             LE  Q+CGLKRKSEE+D++ S +QI++E   L    +T +G   T  T TT  K + ++
Sbjct: 114  LLEPYQKCGLKRKSEEVDSNGS-VQIIEEHPPLMLQNRTVVGAAATTTTVTT--KSSSSS 170

Query: 178  GEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQ 237
            GEGDYQLVQHE+LCSM N+YEVL+FLGRGTFGQV KCWKR T EIVAIKILKNHPSYARQ
Sbjct: 171  GEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQ 230

Query: 238  GQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 297
            GQIEVSIL+RLS+ENADEYNFVR+YECFQH+NHTCLVFEMLEQNLYDFLKQNKFSPLPLK
Sbjct: 231  GQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 290

Query: 298  VIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCS 357
             IRPILQQVATAL KLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK VCS
Sbjct: 291  YIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCS 350

Query: 358  TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGL 417
            TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGA EYDQIRYISQTQGL
Sbjct: 351  TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGL 410

Query: 418  PGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHV 477
            P E LL+ GTK+TRFF ++ ++ +  WRLKT EEHE ETG+KSKEARKYIFN LDD+A V
Sbjct: 411  PAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQV 470

Query: 478  NTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSN 537
            N   DLEG+D+LAEKADRRE++ LLKKML IDAD RITP +TLNH FV M HLLDFPHSN
Sbjct: 471  NMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSN 530

Query: 538  HVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFT-KIGTLRSQALTTS 596
            HVKSCF  M+ICK  ++  DT +  K+     VA +++  LT +F+ ++ T+ +QA   +
Sbjct: 531  HVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLA 590

Query: 597  AHS---------------------------------VVHHGIPLQAGTAQFGCG-DAFQQ 622
            + S                                 V   G+ LQ GT Q     D FQQ
Sbjct: 591  SSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQ 650

Query: 623  TLIICPPAIQ-GIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLS--------- 672
            T I+CPPA Q G+ AT  K + + +R+DN VP+V QAPA QPLQI+ GVL+         
Sbjct: 651  TFIVCPPAFQTGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMV 709

Query: 673  -------------------------------------QTWSGRTQQMLVPA-WQQVTPLA 694
                                                 Q W G TQQ+L+P+ WQQ+  +A
Sbjct: 710  ATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVA 769

Query: 695  ----PATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQP-LLTNQITLSAPQPVSVGI 749
                   T +  E++    +L DW    S  N Y+++M QP LLTN +TL+  QP++VG+
Sbjct: 770  LHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGV 829

Query: 750  AHVVWPQPAT---TKKNKQCQNRGILVKLMEWEPGREEINAFSWSNSLQNTNIPHSAFIS 806
            AHVV  Q ++   +KKNKQ                                    SA +S
Sbjct: 830  AHVVRQQQSSSLPSKKNKQ------------------------------------SAPVS 853

Query: 807  PKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSDKQRQTIIIADSPSPA 866
             K          S ++   +Q       +   T+   +S   V D Q Q III D+PSP 
Sbjct: 854  SK----------SSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQD-QHQPIIIPDTPSPP 902

Query: 867  VSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQS 926
            VSVITI SDTDEEE                                  D+    SSSG  
Sbjct: 903  VSVITIRSDTDEEE----------------------------------DNKYKPSSSG-- 926

Query: 927  SPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVE------DTHENTELV 980
                      +       S  TV+ SP SDSS   SP++  T            E    V
Sbjct: 927  ----------LKPRSNVISYVTVNDSPDSDSS-LSSPYSTDTLSALRGNSGSVLEGPGRV 975

Query: 981  SSADTETKPAVCSVVVPPVELENG--LNADEHMANTDSICQPL--IKGRSAPGRLNQPSA 1036
             +  T T+    +++VPP++ + G    A +      +  +P+  + G+S+ G    P+ 
Sbjct: 976  VADGTGTR----TIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQSS-GCCITPT- 1029

Query: 1037 VGTRQQK-LTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHG 1095
             G R Q+  TSA Q  +L+ +Q        QE + N   RRQQA++   ++  P+T  HG
Sbjct: 1030 -GYRAQRGGTSAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFV-APLSQAPYTFQHG 1087

Query: 1096 SPNHTAVHAHLA-GNTHLGGQPTLLPY---PSSATLSSAAPVAHLLASPCTSRPMLQHPT 1151
            SP H+  H HLA    HL  Q  L  Y    S+A L S + +AHL +   +SR    H  
Sbjct: 1088 SPLHSTGHPHLAPAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQGSSR----HAA 1143

Query: 1152 YNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAA---SPAYTGFPLSPTK 1208
               +HPS +VHQVPV + P LL S ++   QY+  F   SYI +   S  YTG+PLSPTK
Sbjct: 1144 AYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTK 1203

Query: 1209 LSQYPYM 1215
            +SQY Y+
Sbjct: 1204 ISQYSYL 1210


>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
           [Homo sapiens]
          Length = 1075

 Score =  857 bits (2213), Expect = 0.0
 Identities = 519/1030 (50%), Positives = 633/1030 (61%), Gaps = 154/1030 (14%)

Query: 1   MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC-VFQERNYPRTYVNGRNFGNSHPPTKG 59
           MASQ+ V+ P      SSAFCS KKLK+EPS   V  + +  + Y + +      P T+G
Sbjct: 1   MASQLQVFSPP--SVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTL----PATQG 54

Query: 60  SAFQTK--IPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLH 117
            A  +     FN P  ++  L   A  +++        +  A  +  Q+ Q    R+ + 
Sbjct: 55  QANSSHQVANFNIP-AYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVS 113

Query: 118 FLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTT 177
            LE  Q+CGLKRKSEE+D++ S +QI++E   L    +T +G   T  T TT  K + ++
Sbjct: 114 LLEPYQKCGLKRKSEEVDSNGS-VQIIEEHPPLMLQNRTVVGAAATTTTVTT--KSSSSS 170

Query: 178 GEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQ 237
           GEGDYQLVQHE+LCSM N+YEVL+FLGRGTFGQV KCWKR T EIVAIKILKNHPSYARQ
Sbjct: 171 GEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQ 230

Query: 238 GQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 297
           GQIEVSIL+RLS+ENADEYNFVR+YECFQH+NHTCLVFEMLEQNLYDFLKQNKFSPLPLK
Sbjct: 231 GQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 290

Query: 298 VIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCS 357
            IRPILQQVATAL KLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK VCS
Sbjct: 291 YIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCS 350

Query: 358 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGL 417
           TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGA EYDQIRYISQTQGL
Sbjct: 351 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGL 410

Query: 418 PGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHV 477
           P E LL+ GTK+TRFF ++ ++ +  WRLKT EEHE ETG+KSKEARKYIFN LDD+A V
Sbjct: 411 PAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQV 470

Query: 478 NTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSN 537
           N   DLEG+D+LAEKADRRE++ LLKKML IDAD RITP +TLNH FV M HLLDFPHSN
Sbjct: 471 NMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSN 530

Query: 538 HVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFT-KIGTLRSQALTTS 596
           HVKSCF  M+ICK  ++  DT +  K+     VA +++  LT +F+ ++ T+ +QA   +
Sbjct: 531 HVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLA 590

Query: 597 AHS---------------------------------VVHHGIPLQAGTAQFGCG-DAFQQ 622
           + S                                 V   G+ LQ GT Q     D FQQ
Sbjct: 591 SSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQ 650

Query: 623 TLIICPPAIQ-GIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQ-------- 673
           T I+CPPA Q G+ AT  K + + +R+DN VP+V QAPA QPLQI+ GVL+Q        
Sbjct: 651 TFIVCPPAFQTGLQATT-KHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMV 709

Query: 674 --------------------------------------TWSGRTQQMLVPA-WQQVTPLA 694
                                                  W G TQQ+L+P+ WQQ+  +A
Sbjct: 710 ATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVA 769

Query: 695 ----PATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQP-LLTNQITLSAPQPVSVGI 749
                  T +  E++    +L DW    S  N Y+++M QP LLTN +TL+  QP++VG+
Sbjct: 770 LHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGV 829

Query: 750 AHVVWPQPAT---TKKNKQCQNRGILVKLMEWEPGREEINAFSWSNSLQNTNIPHSAFIS 806
           AHVV  Q ++   +KKNKQ                                    SA +S
Sbjct: 830 AHVVRQQQSSSLPSKKNKQ------------------------------------SAPVS 853

Query: 807 PKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSDKQRQTIIIADSPSPA 866
            K          S ++   +Q       +   T+   +S   V D Q Q III D+PSP 
Sbjct: 854 SK----------SSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQD-QHQPIIIPDTPSPP 902

Query: 867 VSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLN--IDRMCSLSSPDSTLSTSSSG 924
           VSVITI SDTDEEE ++                  T+N   D   SLSSP ST + S+  
Sbjct: 903 VSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALR 962

Query: 925 QSSPSPCKRP 934
            +S S  + P
Sbjct: 963 GNSGSVLEGP 972


>gi|38201642 homeodomain-interacting protein kinase 1 isoform 3 [Homo
            sapiens]
          Length = 836

 Score =  500 bits (1287), Expect = e-141
 Identities = 363/943 (38%), Positives = 478/943 (50%), Gaps = 216/943 (22%)

Query: 382  MWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSH 441
            MWSLGCVIAELFLGWPLYPGA EYDQIRYISQTQGLP E LL+ GTK+TRFF ++ ++ +
Sbjct: 1    MWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGY 60

Query: 442  SGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSL 501
              WRLKT EEHE ETG+KSKEARKYIFN LDD+A VN   DLEG+D+LAEKADRRE++ L
Sbjct: 61   PLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDL 120

Query: 502  LKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNSCDTNNH 561
            LKKML IDAD RITP +TLNH FV M HLLDFPHSNHVKSCF  M+ICK  ++  DT + 
Sbjct: 121  LKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQ 180

Query: 562  NKTSLLRPVASSSTATLTANFT-KIGTLRSQALTTSAHS--------------------- 599
             K+     VA +++  LT +F+ ++ T+ +QA   ++ S                     
Sbjct: 181  IKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQS 240

Query: 600  ------------VVHHGIPLQAGTAQFGCG-DAFQQTLIICPPAIQ-GIPATHGKPTSYS 645
                        V   G+ LQ GT Q     D FQQT I+CPPA Q G+ AT  K + + 
Sbjct: 241  ALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQAT-TKHSGFP 299

Query: 646  IRVDNTVPLVTQAPAVQPLQIRPGVLS--------------------------------- 672
            +R+DN VP+V QAPA QPLQI+ GVL+                                 
Sbjct: 300  VRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAA 359

Query: 673  -------------QTWSGRTQQMLVPA-WQQVTPLA----PATTTLTSESVAGSHRLGDW 714
                         Q W G TQQ+L+P+ WQQ+  +A       T +  E++    +L DW
Sbjct: 360  GRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADW 419

Query: 715  GKMISCSNHYNSVMPQP-LLTNQITLSAPQPVSVGIAHVVWPQPAT---TKKNKQCQNRG 770
                S  N Y+++M QP LLTN +TL+  QP++VG+AHVV  Q ++   +KKNKQ     
Sbjct: 420  RNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQ----- 474

Query: 771  ILVKLMEWEPGREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSE 830
                                           SA +S K          S ++   +Q   
Sbjct: 475  -------------------------------SAPVSSK----------SSLDVLPSQVYS 493

Query: 831  GEARNCCETSIRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLREC 890
                +   T+   +S   V D Q Q III D+PSP VSVITI SDTDEEE          
Sbjct: 494  LVGSSPLRTTSSYNSLVPVQD-QHQPIIIPDTPSPPVSVITIRSDTDEEE---------- 542

Query: 891  KGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVD 950
                                    D+    SSSG            +       S  TV+
Sbjct: 543  ------------------------DNKYKPSSSG------------LKPRSNVISYVTVN 566

Query: 951  GSPTSDSSGHDSPFAESTFVE------DTHENTELVSSADTETKPAVCSVVVPPVELENG 1004
             SP SDSS   SP++  T            E    V +  T T+    +++VPP++ + G
Sbjct: 567  DSPDSDSS-LSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGTR----TIIVPPLKTQLG 621

Query: 1005 --LNADEHMANTDSICQPL--IKGRSAPGRLNQPSAVGTRQQK-LTSAFQQQHLNFSQVQ 1059
                A +      +  +P+  + G+S+ G    P+  G R Q+  TSA Q  +L+ +Q  
Sbjct: 622  DCTVATQASGLLSNKTKPVASVSGQSS-GCCITPT--GYRAQRGGTSAAQPLNLSQNQQS 678

Query: 1060 HFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLA-GNTHLGGQPTL 1118
                  QE + N   RRQQA++   ++  P+T  HGSP H+  H HLA    HL  Q  L
Sbjct: 679  SAAPTSQERSSNPAPRRQQAFV-APLSQAPYTFQHGSPLHSTGHPHLAPAPAHLPSQAHL 737

Query: 1119 LPY---PSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPS 1175
              Y    S+A L S + +AHL +   +SR    H     +HPS +VHQVPV + P LL S
Sbjct: 738  YTYAAPTSAAALGSTSSIAHLFSPQGSSR----HAAAYTTHPSTLVHQVPVSVGPSLLTS 793

Query: 1176 PTIHQTQYKPIFPPHSYIAA---SPAYTGFPLSPTKLSQYPYM 1215
             ++   QY+  F   SYI +   S  YTG+PLSPTK+SQY Y+
Sbjct: 794  ASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL 836


>gi|38201644 homeodomain-interacting protein kinase 1 isoform 4 [Homo
            sapiens]
          Length = 816

 Score =  447 bits (1149), Expect = e-125
 Identities = 339/918 (36%), Positives = 454/918 (49%), Gaps = 216/918 (23%)

Query: 407  QIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKY 466
            QIRYISQTQGLP E LL+ GTK+TRFF ++ ++ +  WRLKT EEHE ETG+KSKEARKY
Sbjct: 6    QIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKY 65

Query: 467  IFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVN 526
            IFN LDD+A VN   DLEG+D+LAEKADRRE++ LLKKML IDAD RITP +TLNH FV 
Sbjct: 66   IFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVT 125

Query: 527  MKHLLDFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFT-KI 585
            M HLLDFPHSNHVKSCF  M+ICK  ++  DT +  K+     VA +++  LT +F+ ++
Sbjct: 126  MTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQL 185

Query: 586  GTLRSQALTTSAHS---------------------------------VVHHGIPLQAGTA 612
             T+ +QA   ++ S                                 V   G+ LQ GT 
Sbjct: 186  NTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTT 245

Query: 613  QFGCG-DAFQQTLIICPPAIQ-GIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGV 670
            Q     D FQQT I+CPPA Q G+ AT  K + + +R+DN VP+V QAPA QPLQI+ GV
Sbjct: 246  QICTQTDPFQQTFIVCPPAFQTGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGV 304

Query: 671  LS----------------------------------------------QTWSGRTQQMLV 684
            L+                                              Q W G TQQ+L+
Sbjct: 305  LTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILL 364

Query: 685  PA-WQQVTPLA----PATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQP-LLTNQIT 738
            P+ WQQ+  +A       T +  E++    +L DW    S  N Y+++M QP LLTN +T
Sbjct: 365  PSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVT 424

Query: 739  LSAPQPVSVGIAHVVWPQPAT---TKKNKQCQNRGILVKLMEWEPGREEINAFSWSNSLQ 795
            L+  QP++VG+AHVV  Q ++   +KKNKQ                              
Sbjct: 425  LATAQPLNVGVAHVVRQQQSSSLPSKKNKQ------------------------------ 454

Query: 796  NTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSDKQRQ 855
                  SA +S K          S ++   +Q       +   T+   +S   V D Q Q
Sbjct: 455  ------SAPVSSK----------SSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQD-QHQ 497

Query: 856  TIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPD 915
             III D+PSP VSVITI SDTDEEE                                  D
Sbjct: 498  PIIIPDTPSPPVSVITIRSDTDEEE----------------------------------D 523

Query: 916  STLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVE---- 971
            +    SSSG            +       S  TV+ SP SDSS   SP++  T       
Sbjct: 524  NKYKPSSSG------------LKPRSNVISYVTVNDSPDSDSS-LSSPYSTDTLSALRGN 570

Query: 972  --DTHENTELVSSADTETKPAVCSVVVPPVELENG--LNADEHMANTDSICQPL--IKGR 1025
                 E    V +  T T+    +++VPP++ + G    A +      +  +P+  + G+
Sbjct: 571  SGSVLEGPGRVVADGTGTR----TIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQ 626

Query: 1026 SAPGRLNQPSAVGTRQQK-LTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTS 1084
            S+ G    P+  G R Q+  TSA Q  +L+ +Q        QE + N   RRQQA++   
Sbjct: 627  SS-GCCITPT--GYRAQRGGTSAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFV-AP 682

Query: 1085 VTSNPFTLSHGSPNHTAVHAHLA-GNTHLGGQPTLLPY---PSSATLSSAAPVAHLLASP 1140
            ++  P+T  HGSP H+  H HLA    HL  Q  L  Y    S+A L S + +AHL +  
Sbjct: 683  LSQAPYTFQHGSPLHSTGHPHLAPAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQ 742

Query: 1141 CTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAA---SP 1197
             +SR    H     +HPS +VHQVPV + P LL S ++   QY+  F   SYI +   S 
Sbjct: 743  GSSR----HAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGST 798

Query: 1198 AYTGFPLSPTKLSQYPYM 1215
             YTG+PLSPTK+SQY Y+
Sbjct: 799  IYTGYPLSPTKISQYSYL 816


>gi|169171014 PREDICTED: similar to homeodomain interacting protein
           kinase 2 [Homo sapiens]
          Length = 460

 Score =  436 bits (1122), Expect = e-122
 Identities = 246/375 (65%), Positives = 277/375 (73%), Gaps = 23/375 (6%)

Query: 1   MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC--VFQERNYPRTYVNGRNFGNSHPPTK 58
           MAS V V+ P+  Q  SSAFCSVKKLK+EPSS   +    ++ + Y   +N   S P T 
Sbjct: 8   MASHVQVFSPHTLQ--SSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPAT- 64

Query: 59  GSAFQTKIPFNRPRGHNFSLQ-TSAVVLKNTAGATKVIAAQAQQAHVQA---PQIGAWRN 114
            +   T +P   P     SL     +V   + G   V +A +     Q    P     R+
Sbjct: 65  -TTVSTSLPVPNP-----SLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRS 118

Query: 115 RLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTG---S 171
            +  L+  Q+CGLKRKSEE++N SS +QI++E    P M+Q N     TV TATT    S
Sbjct: 119 TVSLLDTYQKCGLKRKSEEIENTSS-VQIIEEH---PPMIQNNASG-ATVATATTSTATS 173

Query: 172 KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 231
           K + +  EGDYQLVQHEVLCSM NTYEVL+FLGRGTFGQVVKCWKRGTNEIVAIKILKNH
Sbjct: 174 KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 233

Query: 232 PSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKF 291
           PSYARQGQIEVSILARLSTE+AD+YNFVRAYECFQH+NHTCLVFEMLEQNLYDFLKQNKF
Sbjct: 234 PSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293

Query: 292 SPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 351
           SPLPLK IRP+LQQVATAL KLKSLGLIHADLKPENIMLVDP RQPYRVKVIDFGSASHV
Sbjct: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353

Query: 352 SKTVCSTYLQSRYYR 366
           SK VCSTYLQSRYYR
Sbjct: 354 SKAVCSTYLQSRYYR 368


>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
          Length = 616

 Score =  322 bits (825), Expect = 1e-87
 Identities = 172/355 (48%), Positives = 233/355 (65%), Gaps = 8/355 (2%)

Query: 192 SMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE 251
           S  + Y++++ LG+GTFG+V K W+R T E+VAIKILKN     R  + E+ +L  +   
Sbjct: 6   SETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGL 65

Query: 252 NADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALK 311
           + +E + +R  E F       LVFE+LEQNL++F K+N F+PLP + IR +  QV TAL 
Sbjct: 66  DPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALA 125

Query: 312 KLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKT--VCSTYLQSRYYRAPE 369
           +LK L +IHADLKPENIMLVD  R P+RVKVIDFGSAS  S+   V   Y+QSR+YRAPE
Sbjct: 126 RLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185

Query: 370 IILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKS 429
           I+LGLPFCE +D+WSLGCV+AEL LGWPLYPG  EYDQ+RYI +TQGLP   LL+   K+
Sbjct: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245

Query: 430 TRFFCKETDMSHSG-WRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVN-----TVMDL 483
             FF +      +  W+LK+  ++ AET ++  E RKY+  SLD +  VN     + +  
Sbjct: 246 HHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTF 305

Query: 484 EGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNH 538
              + LAE AD +  V L+K+ML  ++  RI+P+  L HPFV+M+ L     + H
Sbjct: 306 PDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360


>gi|169171552 PREDICTED: similar to homeodomain interacting protein
           kinase 3 [Homo sapiens]
          Length = 264

 Score =  228 bits (580), Expect = 3e-59
 Identities = 143/266 (53%), Positives = 172/266 (64%), Gaps = 23/266 (8%)

Query: 1   MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSC--VFQERNYPRTYVNGRNFGNSHPPTK 58
           MAS V V+ P+  Q  SSAFCSVKKLK+EPSS   +    ++ + Y   +N   S P T 
Sbjct: 1   MASHVQVFSPHTLQ--SSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPAT- 57

Query: 59  GSAFQTKIPFNRPRGHNFSLQ-TSAVVLKNTAGATKVIAAQAQQAHVQA---PQIGAWRN 114
            +   T +P   P     SL     +V   + G   V +A +     Q    P     R+
Sbjct: 58  -TTVSTSLPVPNP-----SLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRS 111

Query: 115 RLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTG---S 171
            +  L+  Q+CGLKRKSEE++N SS +QI++E    P M+Q N     TV TATT    S
Sbjct: 112 TVSLLDTYQKCGLKRKSEEIENTSS-VQIIEEH---PPMIQNNASG-ATVATATTSTATS 166

Query: 172 KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 231
           K + +  EGDYQLVQHEVLCSM NTYEVL+FLGRGTFGQVVKCWKRGTNEIVAIKILKNH
Sbjct: 167 KNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNH 226

Query: 232 PSYARQGQIEVSILARLSTENADEYN 257
           PSYARQGQIEVSILARLSTE+AD+YN
Sbjct: 227 PSYARQGQIEVSILARLSTESADDYN 252


>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 5 [Homo sapiens]
          Length = 529

 Score =  215 bits (548), Expect = 2e-55
 Identities = 133/335 (39%), Positives = 188/335 (56%), Gaps = 22/335 (6%)

Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
           YE+   +G+G+FGQVVK + R   E VAIKI+KN  ++  Q QIEV +L  ++  + + +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218

Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
           Y  V     F  RNH CLVFEML  NLYD L+   F  + L + R   QQ+ TAL  L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278

Query: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335

Query: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
           +P+  AIDMWSLGC++ E+  G PL+ GA E DQ+  I +  G+P   +L+   K+ +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

Query: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK- 492
            K  D     W LK  ++ + E   K    RK     L ++  V T     G     E  
Sbjct: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-----LHNILGVET--GGPGGRRAGESG 443

Query: 493 ---ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
              AD  +F  L+ +ML  D   RI P   L H F
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 478


>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 4 [Homo sapiens]
          Length = 540

 Score =  215 bits (548), Expect = 2e-55
 Identities = 133/335 (39%), Positives = 188/335 (56%), Gaps = 22/335 (6%)

Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
           YE+   +G+G+FGQVVK + R   E VAIKI+KN  ++  Q QIEV +L  ++  + + +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218

Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
           Y  V     F  RNH CLVFEML  NLYD L+   F  + L + R   QQ+ TAL  L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278

Query: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335

Query: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
           +P+  AIDMWSLGC++ E+  G PL+ GA E DQ+  I +  G+P   +L+   K+ +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

Query: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK- 492
            K  D     W LK  ++ + E   K    RK     L ++  V T     G     E  
Sbjct: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-----LHNILGVET--GGPGGRRAGESG 443

Query: 493 ---ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
              AD  +F  L+ +ML  D   RI P   L H F
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 478


>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 3 [Homo sapiens]
          Length = 584

 Score =  215 bits (548), Expect = 2e-55
 Identities = 133/335 (39%), Positives = 188/335 (56%), Gaps = 22/335 (6%)

Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
           YE+   +G+G+FGQVVK + R   E VAIKI+KN  ++  Q QIEV +L  ++  + + +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218

Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
           Y  V     F  RNH CLVFEML  NLYD L+   F  + L + R   QQ+ TAL  L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278

Query: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335

Query: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
           +P+  AIDMWSLGC++ E+  G PL+ GA E DQ+  I +  G+P   +L+   K+ +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

Query: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK- 492
            K  D     W LK  ++ + E   K    RK     L ++  V T     G     E  
Sbjct: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-----LHNILGVET--GGPGGRRAGESG 443

Query: 493 ---ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
              AD  +F  L+ +ML  D   RI P   L H F
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 478


>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 2 [Homo sapiens]
          Length = 754

 Score =  215 bits (548), Expect = 2e-55
 Identities = 133/335 (39%), Positives = 188/335 (56%), Gaps = 22/335 (6%)

Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
           YE+   +G+G+FGQVVK + R   E VAIKI+KN  ++  Q QIEV +L  ++  + + +
Sbjct: 150 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 209

Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
           Y  V     F  RNH CLVFEML  NLYD L+   F  + L + R   QQ+ TAL  L +
Sbjct: 210 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 269

Query: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 270 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 326

Query: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
           +P+  AIDMWSLGC++ E+  G PL+ GA E DQ+  I +  G+P   +L+   K+ +FF
Sbjct: 327 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 386

Query: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK- 492
            K  D     W LK  ++ + E   K    RK     L ++  V T     G     E  
Sbjct: 387 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-----LHNILGVET--GGPGGRRAGESG 434

Query: 493 ---ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
              AD  +F  L+ +ML  D   RI P   L H F
Sbjct: 435 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 469


>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1A isoform 1 [Homo sapiens]
          Length = 763

 Score =  215 bits (548), Expect = 2e-55
 Identities = 133/335 (39%), Positives = 188/335 (56%), Gaps = 22/335 (6%)

Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
           YE+   +G+G+FGQVVK + R   E VAIKI+KN  ++  Q QIEV +L  ++  + + +
Sbjct: 159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 218

Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
           Y  V     F  RNH CLVFEML  NLYD L+   F  + L + R   QQ+ TAL  L +
Sbjct: 219 YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 278

Query: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 279 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 335

Query: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
           +P+  AIDMWSLGC++ E+  G PL+ GA E DQ+  I +  G+P   +L+   K+ +FF
Sbjct: 336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

Query: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK- 492
            K  D     W LK  ++ + E   K    RK     L ++  V T     G     E  
Sbjct: 396 EKLPD---GTWNLKKTKDGKRE--YKPPGTRK-----LHNILGVET--GGPGGRRAGESG 443

Query: 493 ---ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
              AD  +F  L+ +ML  D   RI P   L H F
Sbjct: 444 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 478


>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform a [Homo sapiens]
          Length = 629

 Score =  208 bits (529), Expect = 3e-53
 Identities = 127/339 (37%), Positives = 189/339 (55%), Gaps = 30/339 (8%)

Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
           YE+   +G+G+FGQVVK +   T E+VAIKI+KN  ++  Q QIE+ +L  ++  + + +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170

Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
           Y  V     F  RNH CLVFE+L  NLYD L+   F  + L + R + QQ+ TAL  L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230

Query: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287

Query: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
            P+  AIDMWSLGC++ E+  G PL+ G+ E DQ+  I +  G+P   +L+   K+ ++F
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347

Query: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYI----FNSLDDVAHVNTVMDLEGSDLL 489
            +   +   GW L+           ++KE RK         L +V  V T     G    
Sbjct: 348 ER---LPGGGWTLR-----------RTKELRKDYQGPGTRRLQEVLGVQT--GGPGGRRA 391

Query: 490 AEK----ADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
            E     AD   F  L+ +ML  +   RI+P   L H F
Sbjct: 392 GEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGF 430


>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform c [Homo sapiens]
          Length = 601

 Score =  206 bits (523), Expect = 1e-52
 Identities = 122/331 (36%), Positives = 184/331 (55%), Gaps = 42/331 (12%)

Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
           YE+   +G+G+FGQVVK +   T E+VAIKI+KN  ++  Q QIE+ +L  ++  + + +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170

Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
           Y  V     F  RNH CLVFE+L  NLYD L+   F  + L + R + QQ+ TAL  L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230

Query: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287

Query: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
            P+  AIDMWSLGC++ E+  G PL+ G+ E DQ+  I +  G+P   +L+   K+ ++F
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347

Query: 434 CKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKA 493
            +   +   GW L+           ++KE RK                D +G        
Sbjct: 348 ER---LPGGGWTLR-----------RTKELRK----------------DYQG------PG 371

Query: 494 DRREFVSLLKKMLLIDADLRITPAETLNHPF 524
            RR    L+ +ML  +   RI+P   L H F
Sbjct: 372 TRRLQEDLVLRMLEYEPAARISPLGALQHGF 402


>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 1B isoform b [Homo sapiens]
          Length = 589

 Score =  204 bits (520), Expect = 3e-52
 Identities = 106/258 (41%), Positives = 162/258 (62%), Gaps = 9/258 (3%)

Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-E 255
           YE+   +G+G+FGQVVK +   T E+VAIKI+KN  ++  Q QIE+ +L  ++  + + +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170

Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
           Y  V     F  RNH CLVFE+L  NLYD L+   F  + L + R + QQ+ TAL  L +
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230

Query: 316 --LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILG 373
             L +IH DLKPENI+L +P R    +K++DFGS+  + + +   Y+QSR+YR+PE++LG
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLG 287

Query: 374 LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFF 433
            P+  AIDMWSLGC++ E+  G PL+ G+ E DQ+  I +  G+P   +L+   K+ ++F
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347

Query: 434 CKETDMSHSGWRLKTLEE 451
            +   +   GW L+  +E
Sbjct: 348 ER---LPGGGWTLRRTKE 362


>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 4 [Homo sapiens]
          Length = 520

 Score =  204 bits (518), Expect = 5e-52
 Identities = 128/362 (35%), Positives = 189/362 (52%), Gaps = 37/362 (10%)

Query: 171 SKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKN 230
           SK +     G Y  V H+ +      YEVL+ +G+G+FGQV KC     NE+VA+KI++N
Sbjct: 81  SKTSFDDEHGFYLKVLHDHIAYR---YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRN 137

Query: 231 HPSYARQGQIEVSILARLSTENADE-YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQN 289
              + +Q  +E+ IL  L  ++ D  YN V   + F  RNH C+ FE+L  NLY+ +K N
Sbjct: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197

Query: 290 KFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSAS 349
            F    L ++R     V   L+ L    +IH DLKPENI+L    +    VKVIDFGS+ 
Sbjct: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ--KGQASVKVIDFGSSC 255

Query: 350 HVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIR 409
           +  + V  TY+QSR+YR+PE+ILG P+  AIDMWSLGC+ AEL+ G+PL+PG  E +Q+ 
Sbjct: 256 YEHQKVY-TYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLA 314

Query: 410 YISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFN 469
            I +  GLP    +   ++   FF                          SK   K I N
Sbjct: 315 CIMEVLGLPPAGFIQTASRRQTFF-------------------------DSKGFPKNITN 349

Query: 470 SLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKH 529
           +     + ++  DL     +  K     F+  L++ L+ +  LR+TP + L H +++   
Sbjct: 350 NRGKKRYPDS-KDL----TMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSR 404

Query: 530 LL 531
            L
Sbjct: 405 NL 406


>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
           regulated kinase 2 isoform 2 [Homo sapiens]
          Length = 601

 Score =  200 bits (508), Expect = 8e-51
 Identities = 124/359 (34%), Positives = 188/359 (52%), Gaps = 36/359 (10%)

Query: 179 EGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 238
           +G Y  V H+    +   YEVL  +G+G+FGQVVK +    ++ VA+K+++N   + RQ 
Sbjct: 207 QGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQA 263

Query: 239 QIEVSILARLSTENADE-YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 297
             E+ IL  L  ++ D   N +   E F  RNH C+ FE+L  NLY+ +K+NKF    L 
Sbjct: 264 AEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLP 323

Query: 298 VIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCS 357
           ++R     +   L  L    +IH DLKPENI+L    R    +KVIDFGS+ +  + V  
Sbjct: 324 LVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDFGSSCYEHQRVY- 380

Query: 358 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGL 417
           TY+QSR+YRAPE+ILG  +   IDMWSLGC++AEL  G+PL PG  E DQ+  + +  G+
Sbjct: 381 TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGM 440

Query: 418 PGEQLLNVGTKSTRF--------FCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFN 469
           P ++LL+   ++  F        +C  T +S     L        +      E+R++   
Sbjct: 441 PSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKL-RGPPESREW--- 496

Query: 470 SLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMK 528
                          G+ L  +  D   F+  LK+ L  D  +R+TP + L HP++  +
Sbjct: 497 ---------------GNAL--KGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR 538


>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 2 isoform 1 [Homo sapiens]
          Length = 528

 Score =  200 bits (508), Expect = 8e-51
 Identities = 124/359 (34%), Positives = 188/359 (52%), Gaps = 36/359 (10%)

Query: 179 EGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 238
           +G Y  V H+    +   YEVL  +G+G+FGQVVK +    ++ VA+K+++N   + RQ 
Sbjct: 134 QGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQA 190

Query: 239 QIEVSILARLSTENADE-YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 297
             E+ IL  L  ++ D   N +   E F  RNH C+ FE+L  NLY+ +K+NKF    L 
Sbjct: 191 AEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLP 250

Query: 298 VIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCS 357
           ++R     +   L  L    +IH DLKPENI+L    R    +KVIDFGS+ +  + V  
Sbjct: 251 LVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDFGSSCYEHQRVY- 307

Query: 358 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGL 417
           TY+QSR+YRAPE+ILG  +   IDMWSLGC++AEL  G+PL PG  E DQ+  + +  G+
Sbjct: 308 TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGM 367

Query: 418 PGEQLLNVGTKSTRF--------FCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFN 469
           P ++LL+   ++  F        +C  T +S     L        +      E+R++   
Sbjct: 368 PSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKL-RGPPESREW--- 423

Query: 470 SLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMK 528
                          G+ L  +  D   F+  LK+ L  D  +R+TP + L HP++  +
Sbjct: 424 ---------------GNAL--KGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR 465


>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 3 isoform b [Homo sapiens]
          Length = 568

 Score =  188 bits (478), Expect = 2e-47
 Identities = 114/331 (34%), Positives = 174/331 (52%), Gaps = 17/331 (5%)

Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTEN-ADE 255
           YEVL  +G+G+FGQV + +     + VA+K+++N   + RQ   E+ IL  L  ++    
Sbjct: 189 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 248

Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
            N +   E F  RNH C+ FE+L  +LY+ +K+NKF    ++++R   Q +  +L  L  
Sbjct: 249 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 308

Query: 316 LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLP 375
             +IH DLKPENI+L    R     KVIDFGS+    + +  TY+QSR+YRAPEIILG  
Sbjct: 309 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGSR 365

Query: 376 FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCK 435
           +   ID+WS GC++AEL  G PL+PG  E DQ+  + +  G+P  +LL   +K  ++F  
Sbjct: 366 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE-QSKRAKYFIN 424

Query: 436 ETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADR 495
              +          +      G +S+  +K       D         L+G        D 
Sbjct: 425 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA-----LKG-------CDD 472

Query: 496 REFVSLLKKMLLIDADLRITPAETLNHPFVN 526
             F+  LK+ L  D   R+TPA+ L HP+++
Sbjct: 473 YLFIEFLKRCLHWDPSARLTPAQALRHPWIS 503


>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
           kinase 3 isoform a [Homo sapiens]
          Length = 588

 Score =  188 bits (478), Expect = 2e-47
 Identities = 114/331 (34%), Positives = 174/331 (52%), Gaps = 17/331 (5%)

Query: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTEN-ADE 255
           YEVL  +G+G+FGQV + +     + VA+K+++N   + RQ   E+ IL  L  ++    
Sbjct: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268

Query: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
            N +   E F  RNH C+ FE+L  +LY+ +K+NKF    ++++R   Q +  +L  L  
Sbjct: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328

Query: 316 LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLP 375
             +IH DLKPENI+L    R     KVIDFGS+    + +  TY+QSR+YRAPEIILG  
Sbjct: 329 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGSR 385

Query: 376 FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCK 435
           +   ID+WS GC++AEL  G PL+PG  E DQ+  + +  G+P  +LL   +K  ++F  
Sbjct: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE-QSKRAKYFIN 444

Query: 436 ETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADR 495
              +          +      G +S+  +K       D         L+G        D 
Sbjct: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA-----LKG-------CDD 492

Query: 496 REFVSLLKKMLLIDADLRITPAETLNHPFVN 526
             F+  LK+ L  D   R+TPA+ L HP+++
Sbjct: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523


>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
          Length = 1007

 Score =  171 bits (432), Expect = 5e-42
 Identities = 115/362 (31%), Positives = 186/362 (51%), Gaps = 25/362 (6%)

Query: 172  KQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRG-TNEIVAIKILKN 230
            + N T  EG Y++   EVL      Y V  + G+G F  VV+       N+ VA+KI++N
Sbjct: 665  RDNWTDAEGYYRVNIGEVL---DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRN 721

Query: 231  HPSYARQGQIEVSILARLSTENADE-YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ- 288
            +    + G  E+  L +L+  + D+ ++ +R +  F H+ H CLVFE L  NL + LK+ 
Sbjct: 722  NELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKY 781

Query: 289  NKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSA 348
             K   L +K +R   QQ+  ALK LK   ++HAD+KP+NI++ +       +K+ DFGSA
Sbjct: 782  GKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNE---SKTILKLCDFGSA 838

Query: 349  SHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQI 408
            SHV+    + YL SR+YRAPEII+G  +   IDMWS+GC + EL+ G  L+PG      +
Sbjct: 839  SHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHML 898

Query: 409  RYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIF 468
            +     +G    +++  G    + F  + +++     +  + E E  T M +    K   
Sbjct: 899  KLAMDLKGKMPNKMIRKGVFKDQHF--DQNLNFMYIEVDKVTEREKVTVMSTINPTK--- 953

Query: 469  NSLDDVAHVNTVMDLEGSDLLAEKADRR--EFVSLLKKMLLIDADLRITPAETLNHPFVN 526
                     + + DL G   L E   ++  +   LL ++L++D   RI+  + L H F+ 
Sbjct: 954  ---------DLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQ 1004

Query: 527  MK 528
             K
Sbjct: 1005 EK 1006


>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
          Length = 526

 Score =  162 bits (411), Expect = 1e-39
 Identities = 106/348 (30%), Positives = 174/348 (50%), Gaps = 46/348 (13%)

Query: 197 YEVLDFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADE 255
           YE++D LG G FG+VV+C   +     VA+KI+KN   Y    + E+ +L  L+T + + 
Sbjct: 203 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 262

Query: 256 -YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLK 314
            +  V+  E F+H  H C+VFE+L  + YDF+K+N F P  L  IR +  Q+  ++  L 
Sbjct: 263 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 322

Query: 315 SLGLIHADLKPENIMLVD---------PVRQPYR------VKVIDFGSASHVSKTVCSTY 359
           S  L H DLKPENI+ V           +++  R      +KV+DFGSA++  +   ST 
Sbjct: 323 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 381

Query: 360 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPG 419
           + +R+YRAPE+IL L + +  D+WS+GC++ E +LG+ ++P     + +  + +  G   
Sbjct: 382 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 441

Query: 420 EQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNT 479
           + ++    K   F     D     W     +EH +        A +Y+      +     
Sbjct: 442 KHMIQKTRKRKYFHHDRLD-----W-----DEHSS--------AGRYVSRRCKPLKEF-- 481

Query: 480 VMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNM 527
                   +L++  +      L++KML  D   RIT  E L HPF ++
Sbjct: 482 --------MLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDL 521


>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
          Length = 484

 Score =  162 bits (411), Expect = 1e-39
 Identities = 106/348 (30%), Positives = 174/348 (50%), Gaps = 46/348 (13%)

Query: 197 YEVLDFLGRGTFGQVVKCWK-RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADE 255
           YE++D LG G FG+VV+C   +     VA+KI+KN   Y    + E+ +L  L+T + + 
Sbjct: 161 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 220

Query: 256 -YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLK 314
            +  V+  E F+H  H C+VFE+L  + YDF+K+N F P  L  IR +  Q+  ++  L 
Sbjct: 221 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 280

Query: 315 SLGLIHADLKPENIMLVD---------PVRQPYR------VKVIDFGSASHVSKTVCSTY 359
           S  L H DLKPENI+ V           +++  R      +KV+DFGSA++  +   ST 
Sbjct: 281 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH-HSTL 339

Query: 360 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPG 419
           + +R+YRAPE+IL L + +  D+WS+GC++ E +LG+ ++P     + +  + +  G   
Sbjct: 340 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 399

Query: 420 EQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNT 479
           + ++    K   F     D     W     +EH +        A +Y+      +     
Sbjct: 400 KHMIQKTRKRKYFHHDRLD-----W-----DEHSS--------AGRYVSRRCKPLKEF-- 439

Query: 480 VMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNM 527
                   +L++  +      L++KML  D   RIT  E L HPF ++
Sbjct: 440 --------MLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDL 479


>gi|10190706 CDC-like kinase 4 [Homo sapiens]
          Length = 481

 Score =  158 bits (400), Expect = 3e-38
 Identities = 104/352 (29%), Positives = 174/352 (49%), Gaps = 46/352 (13%)

Query: 193 MKNTYEVLDFLGRGTFGQVVKCWKRGTNEI-VAIKILKNHPSYARQGQIEVSILARL-ST 250
           ++  YE++D LG G FG+VV+C   G + + VA+KI+KN   Y    + E+ +L  L ST
Sbjct: 155 LRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNST 214

Query: 251 ENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATAL 310
           +    +  V+  E F H  H C+VFE+L  + YDF+K+N F P  +  IR +  Q+  ++
Sbjct: 215 DPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSI 274

Query: 311 KKLKSLGLIHADLKPENIMLV---------DPVRQPYR------VKVIDFGSASHVSKTV 355
             L    L H DLKPENI+ V           +++  R      +KV+DFGSA++  +  
Sbjct: 275 NFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEH- 333

Query: 356 CSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQ 415
            ST + +R+YRAPE+IL L + +  D+WS+GC++ E +LG+ ++      + +  + +  
Sbjct: 334 HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERIL 393

Query: 416 GLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVA 475
           G   + ++    K   F   + D     W     +EH +        A +Y+      + 
Sbjct: 394 GPIPQHMIQKTRKRKYFHHNQLD-----W-----DEHSS--------AGRYVRRRCKPLK 435

Query: 476 HVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNM 527
                       +L    +  +   L+++ML  D   RIT  E L HPF ++
Sbjct: 436 EF----------MLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDL 477


>gi|47717134 CDC-like kinase 2 [Homo sapiens]
          Length = 498

 Score =  152 bits (385), Expect = 1e-36
 Identities = 100/350 (28%), Positives = 172/350 (49%), Gaps = 48/350 (13%)

Query: 193 MKNTYEVLDFLGRGTFGQVVKC--WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST 250
           ++  YE++  LG GTFG+VV+C   +RG    VA+KI+KN   Y    ++E+++L +++ 
Sbjct: 158 LQERYEIVSTLGEGTFGRVVQCVDHRRGGAR-VALKIIKNVEKYKEAARLEINVLEKINE 216

Query: 251 ENADEYNF-VRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATA 309
           ++ D  N  V+ ++ F +  H C+ FE+L  + +DFLK N + P P+  +R +  Q+  A
Sbjct: 217 KDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQA 276

Query: 310 LKKLKSLGLIHADLKPENIMLVDPVRQ---------------PYRVKVIDFGSASHVSKT 354
           +K L    L H DLKPENI+ V+   +                  V+V+DFGSA+     
Sbjct: 277 VKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT-FDHE 335

Query: 355 VCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQT 414
             ST + +R+YRAPE+IL L + +  D+WS+GC+I E ++G+ L+      + +  + + 
Sbjct: 336 HHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERI 395

Query: 415 QGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDV 474
            G    +++    K   F+    D   +    + + E+        K  R+Y        
Sbjct: 396 LGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVREN-------CKPLRRY-------- 440

Query: 475 AHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
                        L +E  +  +   L++ ML  +   R+T  E L HPF
Sbjct: 441 -------------LTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPF 477


>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
          Length = 638

 Score =  142 bits (359), Expect = 1e-33
 Identities = 100/352 (28%), Positives = 174/352 (49%), Gaps = 52/352 (14%)

Query: 193 MKNTYEVLDFLGRGTFGQVVKCWK--RGTNEIVAIKILKNHPSYARQGQIEVSILARLST 250
           ++  YE++  LG GTFG+VV+C    RG ++ VA+KI++N   Y    ++E+++L ++  
Sbjct: 300 LQERYEIVGNLGEGTFGKVVECLDHARGKSQ-VALKIIRNVGKYREAARLEINVLKKIKE 358

Query: 251 ENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATA 309
           ++ + ++  V   + F    H C+ FE+L +N ++FLK+N F P PL  +R +  Q+  A
Sbjct: 359 KDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHA 418

Query: 310 LKKLKSLGLIHADLKPENIMLVDPVRQPY---------------RVKVIDFGSAS--HVS 352
           L+ L    L H DLKPENI+ V+   +                  ++V DFGSA+  H  
Sbjct: 419 LRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEH 478

Query: 353 KTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYIS 412
            T   T + +R+YR PE+IL L + +  D+WS+GC++ E + G+ L+      + +  + 
Sbjct: 479 HT---TIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMME 535

Query: 413 QTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLD 472
           +  G     +++  T+  ++F K             + +  +  G   KE  K +     
Sbjct: 536 KILGPIPSHMIH-RTRKQKYFYKG----------GLVWDENSSDGRYVKENCKPL----- 579

Query: 473 DVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPF 524
                        S +L +  +  +   L+++ML  D   RIT AE L HPF
Sbjct: 580 ------------KSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPF 619


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.129    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,600,088
Number of Sequences: 37866
Number of extensions: 2438365
Number of successful extensions: 11001
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 435
Number of HSP's successfully gapped in prelim test: 477
Number of HSP's that attempted gapping in prelim test: 8094
Number of HSP's gapped (non-prelim): 2031
length of query: 1215
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1101
effective length of database: 13,930,794
effective search space: 15337804194
effective search space used: 15337804194
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.