Guide to the Human Genome
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Search of human proteins with 219802706

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]
         (934 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]           1879   0.0  
gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]           1850   0.0  
gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]             1848   0.0  
gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]           362   1e-99
gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]           349   8e-96
gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]             329   6e-90
gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]           329   6e-90
gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]           320   5e-87
gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]           303   5e-82
gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]             288   2e-77
gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]             288   2e-77
gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]             288   2e-77
gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]            283   4e-76
gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]            282   1e-75
gi|157364939 phosphodiesterase 6C [Homo sapiens]                      259   1e-68
gi|170650674 phosphodiesterase 6A [Homo sapiens]                      256   9e-68
gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]            249   8e-66
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]             156   7e-38
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]             156   7e-38
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]             156   7e-38
gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]             156   7e-38
gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens]             156   7e-38
gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens]             156   7e-38
gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens]             156   7e-38
gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens]             156   7e-38
gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens]             156   7e-38
gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens]             156   7e-38
gi|48762734 phosphodiesterase 9A isoform i [Homo sapiens]             156   7e-38
gi|48762732 phosphodiesterase 9A isoform h [Homo sapiens]             156   7e-38
gi|48762730 phosphodiesterase 9A isoform g [Homo sapiens]             156   7e-38

>gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]
          Length = 934

 Score = 1879 bits (4867), Expect = 0.0
 Identities = 934/934 (100%), Positives = 934/934 (100%)

Query: 1   MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAV 60
           MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAV
Sbjct: 1   MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAV 60

Query: 61  KEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDL 120
           KEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDL
Sbjct: 61  KEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDL 120

Query: 121 PGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVA 180
           PGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVA
Sbjct: 121 PGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVA 180

Query: 181 LRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQL 240
           LRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQL
Sbjct: 181 LRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQL 240

Query: 241 KVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQ 300
           KVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQ
Sbjct: 241 KVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQ 300

Query: 301 LKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQ 360
           LKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQ
Sbjct: 301 LKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQ 360

Query: 361 HCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNA 420
           HCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNA
Sbjct: 361 HCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNA 420

Query: 421 EICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLF 480
           EICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLF
Sbjct: 421 EICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLF 480

Query: 481 YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGIS 540
           YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGIS
Sbjct: 481 YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGIS 540

Query: 541 IAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTP 600
           IAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTP
Sbjct: 541 IAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTP 600

Query: 601 RSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHF 660
           RSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHF
Sbjct: 601 RSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHF 660

Query: 661 CYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVME 720
           CYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVME
Sbjct: 661 CYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVME 720

Query: 721 RHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVG 780
           RHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVG
Sbjct: 721 RHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVG 780

Query: 781 YDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEM 840
           YDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEM
Sbjct: 781 YDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEM 840

Query: 841 MDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGL 900
           MDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGL
Sbjct: 841 MDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGL 900

Query: 901 PSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE 934
           PSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
Sbjct: 901 PSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE 934


>gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]
          Length = 932

 Score = 1850 bits (4791), Expect = 0.0
 Identities = 918/918 (100%), Positives = 918/918 (100%)

Query: 17  RRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYT 76
           RRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYT
Sbjct: 15  RRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYT 74

Query: 77  YLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDT 136
           YLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDT
Sbjct: 75  YLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDT 134

Query: 137 QVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAP 196
           QVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAP
Sbjct: 135 QVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAP 194

Query: 197 RAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCC 256
           RAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCC
Sbjct: 195 RAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCC 254

Query: 257 LLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSML 316
           LLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSML
Sbjct: 255 LLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSML 314

Query: 317 GCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAF 376
           GCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAF
Sbjct: 315 GCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAF 374

Query: 377 QKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAK 436
           QKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAK
Sbjct: 375 QKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAK 434

Query: 437 VFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNIL 496
           VFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNIL
Sbjct: 435 VFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNIL 494

Query: 497 CFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYR 556
           CFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYR
Sbjct: 495 CFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYR 554

Query: 557 SHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSML 616
           SHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSML
Sbjct: 555 SHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSML 614

Query: 617 QDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLED 676
           QDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLED
Sbjct: 615 QDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLED 674

Query: 677 IEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGC 736
           IEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGC
Sbjct: 675 IEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGC 734

Query: 737 NIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLL 796
           NIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLL
Sbjct: 735 NIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLL 794

Query: 797 MTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFM 856
           MTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFM
Sbjct: 795 MTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFM 854

Query: 857 EHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVP 916
           EHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVP
Sbjct: 855 EHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVP 914

Query: 917 DLDGTRAPINGCCSLDAE 934
           DLDGTRAPINGCCSLDAE
Sbjct: 915 DLDGTRAPINGCCSLDAE 932


>gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]
          Length = 941

 Score = 1848 bits (4786), Expect = 0.0
 Identities = 917/917 (100%), Positives = 917/917 (100%)

Query: 18  RGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTY 77
           RGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTY
Sbjct: 25  RGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTY 84

Query: 78  LLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQ 137
           LLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQ
Sbjct: 85  LLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQ 144

Query: 138 VLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPR 197
           VLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPR
Sbjct: 145 VLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPR 204

Query: 198 AVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCL 257
           AVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCL
Sbjct: 205 AVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCL 264

Query: 258 LLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLG 317
           LLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLG
Sbjct: 265 LLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLG 324

Query: 318 CELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQ 377
           CELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQ
Sbjct: 325 CELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQ 384

Query: 378 KEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKV 437
           KEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKV
Sbjct: 385 KEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKV 444

Query: 438 FDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILC 497
           FDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILC
Sbjct: 445 FDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILC 504

Query: 498 FPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRS 557
           FPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRS
Sbjct: 505 FPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRS 564

Query: 558 HLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ 617
           HLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ
Sbjct: 565 HLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ 624

Query: 618 DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDI 677
           DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDI
Sbjct: 625 DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDI 684

Query: 678 EIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCN 737
           EIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCN
Sbjct: 685 EIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCN 744

Query: 738 IFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLM 797
           IFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLM
Sbjct: 745 IFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLM 804

Query: 798 TSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFME 857
           TSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFME
Sbjct: 805 TSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFME 864

Query: 858 HIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPD 917
           HIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPD
Sbjct: 865 HIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPD 924

Query: 918 LDGTRAPINGCCSLDAE 934
           LDGTRAPINGCCSLDAE
Sbjct: 925 LDGTRAPINGCCSLDAE 941


>gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]
          Length = 933

 Score =  362 bits (928), Expect = 1e-99
 Identities = 229/722 (31%), Positives = 368/722 (50%), Gaps = 64/722 (8%)

Query: 232 DLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGC--- 288
           DLD +SL  K+L ++     A RC L LV  +      K +  K        PL  C   
Sbjct: 215 DLDLTSLSYKILIFVCLMVDADRCSLFLV--EGAAAGKKTLVSKFFDVHAGTPLLPCSST 272

Query: 289 --------------LGQVVEDKKSIQLKDLTSEDV--QQLQSMLGCELQAMLCVPVISRA 332
                         +G V E  +++ + D   +     ++  + G + +++LC+P+ S +
Sbjct: 273 ENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRS-S 331

Query: 333 TDQVVALACAFNKL-EGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQ 391
             +++ +A A NK+ EG  FT++DE V+Q    +    +++   F   +K     +ALL+
Sbjct: 332 DGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLE 391

Query: 392 VAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIR 451
           V  +LF    D+  ++++I+  A+ L   E CSV LL+  E     F       +S+E+ 
Sbjct: 392 VVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFT------KSFELM 445

Query: 452 IPA-----------------------DQGIAGHVATTGQILNIPDAYAHPLFYRGVDDST 488
            P                        +  IA  VA+TG  +NI DAY  P F    D  +
Sbjct: 446 SPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQIS 505

Query: 489 GFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYK 548
           GF  R++LC PI N N ++IGVA+++N+++G  F   D+ L  AF I+CG+ I ++++Y 
Sbjct: 506 GFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYD 565

Query: 549 KVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAI---DSNFASFTYTPRSLPE 605
           +V ++  +  +A +++ YH   S  E  K     I  V+ +   D +F  F     SL  
Sbjct: 566 QVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDF-----SLDV 620

Query: 606 DDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLY 665
           D    A L M  ++  +  +KID  TL R+ L V+K YR   YHNW HAF+V    + + 
Sbjct: 621 DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAML 680

Query: 666 KNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFA 725
                 + L ++EI A+ + C+CHDLDHRGTNN+FQ  S S LA LY +  + +E HHF 
Sbjct: 681 TTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGT-SATLEHHHFN 739

Query: 726 QAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRN 784
            A+ IL + G NIF + S K+Y  ++ L++  ILATDL  +     +  ++   G YD N
Sbjct: 740 HAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWN 799

Query: 785 NKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDR 843
            K H  +   +LMT+CDL   TK W+ +R++AEL+  EFF QGD E+  +   P  + DR
Sbjct: 800 IKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDR 859

Query: 844 -EKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPS 902
             K  +P LQ+ +++ I MP+Y+ L  +  K   + + VA+NR  W ++  K  +    S
Sbjct: 860 NRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTAS 919

Query: 903 NN 904
           ++
Sbjct: 920 SS 921


>gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]
          Length = 683

 Score =  349 bits (895), Expect = 8e-96
 Identities = 210/639 (32%), Positives = 340/639 (53%), Gaps = 45/639 (7%)

Query: 296 KKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKL-EGDLFTDE 354
           ++  + KD    D  ++  + G + +++LC+P+ S +  +++ +A A NK+ EG  FT++
Sbjct: 48  QRQTKTKDRRFND--EIDKLTGYKTKSLLCMPIRS-SDGEIIGVAQAINKIPEGAPFTED 104

Query: 355 DEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEA 414
           DE V+Q    +    +++   F   +K     +ALL+V  +LF    D+  ++++I+  A
Sbjct: 105 DEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRA 164

Query: 415 RNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPA-------------------- 454
           + L   E CSV LL+  E     F       +S+E+  P                     
Sbjct: 165 QTLLKCERCSVLLLEDIESPVVKFT------KSFELMSPKCSADAENSFKESMEKSSYSD 218

Query: 455 ---DQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVA 511
              +  IA  VA+TG  +NI DAY  P F    D  +GF  R++LC PI N N ++IGVA
Sbjct: 219 WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVA 278

Query: 512 ELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVS 571
           +++N+++G  F   D+ L  AF I+CG+ I ++++Y +V ++  +  +A +++ YH   S
Sbjct: 279 QVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCS 338

Query: 572 DDEYTKLLHDGIQPVAAI---DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKID 628
             E  K     I  V+ +   D +F  F     SL  D    A L M  ++  +  +KID
Sbjct: 339 KAEVDKFKAANIPLVSELAIDDIHFDDF-----SLDVDAMITAALRMFMELGMVQKFKID 393

Query: 629 CPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMC 688
             TL R+ L V+K YR   YHNW HAF+V    + +       + L ++EI A+ + C+C
Sbjct: 394 YETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLC 453

Query: 689 HDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQ 748
           HDLDHRGTNN+FQ  S S LA LY +  + +E HHF  A+ IL + G NIF + S K+Y 
Sbjct: 454 HDLDHRGTNNAFQAKSGSALAQLYGT-SATLEHHHFNHAVMILQSEGHNIFANLSSKEYS 512

Query: 749 RMLDLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTK 807
            ++ L++  ILATDL  +     +  ++   G YD N K H  +   +LMT+CDL   TK
Sbjct: 513 DLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTK 572

Query: 808 GWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDR-EKAYIPELQISFMEHIAMPIYK 865
            W+ +R++AEL+  EFF QGD E+  +   P  + DR  K  +P LQ+ +++ I MP+Y+
Sbjct: 573 PWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQ 632

Query: 866 LLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNN 904
            L  +  K   + + VA+NR  W ++  K  +    S++
Sbjct: 633 ALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSS 671


>gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]
          Length = 779

 Score =  329 bits (844), Expect = 6e-90
 Identities = 208/622 (33%), Positives = 330/622 (53%), Gaps = 43/622 (6%)

Query: 292 VVEDKKSIQLKDLTSEDVQQLQSML--GCELQAMLCVPVISRATDQVVALACAFNKLEGD 349
           V + +K++ ++D+  ++     + L  G  +Q++LC+P+++   D ++ +   +     +
Sbjct: 155 VAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGD-LIGILELYRHWGKE 213

Query: 350 LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQE 409
            F    + V      + S  +      +   K       LL V+K  F ++  +  LL+ 
Sbjct: 214 AFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEH 273

Query: 410 IITEARNLSNAEICSVFLLDQN--ELVAKVFD------GGVVDDESYEIRIPADQGIAGH 461
           I+  A+NL NA+ C++F +D    EL + +FD      G  V  ++ EIR   ++GIAG 
Sbjct: 274 IMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQ 333

Query: 462 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 521
           VA TG++LNIPDAYA P F R VD  TG+ TRNILC PI +    VIGV ++VNKI+G  
Sbjct: 334 VARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRG-SVIGVVQMVNKISGSA 392

Query: 522 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 581
           FSK DE+    F+++C +++  + +Y ++  ++    +  E + YH   + +E+  L+  
Sbjct: 393 FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM-- 450

Query: 582 GIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDM---NFINNYKIDCPT------- 631
                         FT   R   E +     +   ++M    F+      C T       
Sbjct: 451 -------------QFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEK 497

Query: 632 LARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDL 691
           L RF + VKK YR  PYHNW HA +V+H  Y + +N        D+E   L I+C+CHDL
Sbjct: 498 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDL 555

Query: 692 DHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRML 751
           DHRG +NS+       LAALYS+  S ME+HHF+Q ++IL   G NIF   S  +Y+++L
Sbjct: 556 DHRGFSNSYLQKFDHPLAALYST--STMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVL 613

Query: 752 DLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWK 810
           +++R  I+ATDLA +    K L++M + G  + NN+ H   ++ L+MT+CDL   TK W 
Sbjct: 614 EIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP 673

Query: 811 TTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQD 869
            T+  A  IY EF+++GD  K +G +P+ MMDR+K   +P+ Q+ F   +A+P Y  L  
Sbjct: 674 VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQ 733

Query: 870 LFPKAAELYERVASNREHWTKV 891
           + P    L +    N   W KV
Sbjct: 734 ILPPTEPLLKACRDNLSQWEKV 755



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 2/91 (2%)

Query: 453 PADQG--IAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGV 510
           P  QG  ++ +VA + + L + D      F RG    +G R +++LC PI     ++IG+
Sbjct: 144 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 203

Query: 511 AELVNKINGPWFSKFDEDLATAFSIYCGISI 541
            EL        F    +++ATA   +  ++I
Sbjct: 204 LELYRHWGKEAFCLSHQEVATANLAWASVAI 234


>gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]
          Length = 789

 Score =  329 bits (844), Expect = 6e-90
 Identities = 208/622 (33%), Positives = 330/622 (53%), Gaps = 43/622 (6%)

Query: 292 VVEDKKSIQLKDLTSEDVQQLQSML--GCELQAMLCVPVISRATDQVVALACAFNKLEGD 349
           V + +K++ ++D+  ++     + L  G  +Q++LC+P+++   D ++ +   +     +
Sbjct: 165 VAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGD-LIGILELYRHWGKE 223

Query: 350 LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQE 409
            F    + V      + S  +      +   K       LL V+K  F ++  +  LL+ 
Sbjct: 224 AFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEH 283

Query: 410 IITEARNLSNAEICSVFLLDQN--ELVAKVFD------GGVVDDESYEIRIPADQGIAGH 461
           I+  A+NL NA+ C++F +D    EL + +FD      G  V  ++ EIR   ++GIAG 
Sbjct: 284 IMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQ 343

Query: 462 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 521
           VA TG++LNIPDAYA P F R VD  TG+ TRNILC PI +    VIGV ++VNKI+G  
Sbjct: 344 VARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRG-SVIGVVQMVNKISGSA 402

Query: 522 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 581
           FSK DE+    F+++C +++  + +Y ++  ++    +  E + YH   + +E+  L+  
Sbjct: 403 FSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM-- 460

Query: 582 GIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDM---NFINNYKIDCPT------- 631
                         FT   R   E +     +   ++M    F+      C T       
Sbjct: 461 -------------QFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEK 507

Query: 632 LARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDL 691
           L RF + VKK YR  PYHNW HA +V+H  Y + +N        D+E   L I+C+CHDL
Sbjct: 508 LCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDL 565

Query: 692 DHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRML 751
           DHRG +NS+       LAALYS+  S ME+HHF+Q ++IL   G NIF   S  +Y+++L
Sbjct: 566 DHRGFSNSYLQKFDHPLAALYST--STMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVL 623

Query: 752 DLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWK 810
           +++R  I+ATDLA +    K L++M + G  + NN+ H   ++ L+MT+CDL   TK W 
Sbjct: 624 EIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP 683

Query: 811 TTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQD 869
            T+  A  IY EF+++GD  K +G +P+ MMDR+K   +P+ Q+ F   +A+P Y  L  
Sbjct: 684 VTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQ 743

Query: 870 LFPKAAELYERVASNREHWTKV 891
           + P    L +    N   W KV
Sbjct: 744 ILPPTEPLLKACRDNLSQWEKV 765



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 25/91 (27%), Positives = 44/91 (48%), Gaps = 2/91 (2%)

Query: 453 PADQG--IAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGV 510
           P  QG  ++ +VA + + L + D      F RG    +G R +++LC PI     ++IG+
Sbjct: 154 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 213

Query: 511 AELVNKINGPWFSKFDEDLATAFSIYCGISI 541
            EL        F    +++ATA   +  ++I
Sbjct: 214 LELYRHWGKEAFCLSHQEVATANLAWASVAI 244


>gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]
          Length = 575

 Score =  320 bits (819), Expect = 5e-87
 Identities = 190/569 (33%), Positives = 299/569 (52%), Gaps = 41/569 (7%)

Query: 365 YTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICS 424
           +    +++   F   +K     +ALL+V  +LF    D+  ++++I+  A+ L   E CS
Sbjct: 7   FCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCS 66

Query: 425 VFLLDQNELVAKVFDGGVVDDESYEIRIPA-----------------------DQGIAGH 461
           V LL+  E     F       +S+E+  P                        +  IA  
Sbjct: 67  VLLLEDIESPVVKFT------KSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAEL 120

Query: 462 VATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW 521
           VA+TG  +NI DAY  P F    D  +GF  R++LC PI N N ++IGVA+++N+++G  
Sbjct: 121 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 180

Query: 522 FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD 581
           F   D+ L  AF I+CG+ I ++++Y +V ++  +  +A +++ YH   S  E  K    
Sbjct: 181 FDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAA 240

Query: 582 GIQPVAAI---DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLM 638
            I  V+ +   D +F  F     SL  D    A L M  ++  +  +KID  TL R+ L 
Sbjct: 241 NIPLVSELAIDDIHFDDF-----SLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLT 295

Query: 639 VKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNN 698
           V+K YR   YHNW HAF+V    + +       + L ++EI A+ + C+CHDLDHRGTNN
Sbjct: 296 VRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNN 355

Query: 699 SFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDII 758
           +FQ  S S LA LY +  + +E HHF  A+ IL + G NIF + S K+Y  ++ L++  I
Sbjct: 356 AFQAKSGSALAQLYGT-SATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSI 414

Query: 759 LATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE 817
           LATDL  +     +  ++   G YD N K H  +   +LMT+CDL   TK W+ +R++AE
Sbjct: 415 LATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAE 474

Query: 818 LIYKEFFSQGDLEK-AMGNRPMEMMDR-EKAYIPELQISFMEHIAMPIYKLLQDLFPKAA 875
           L+  EFF QGD E+  +   P  + DR  K  +P LQ+ +++ I MP+Y+ L  +  K  
Sbjct: 475 LVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLK 534

Query: 876 ELYERVASNREHWTKVSHKFTIRGLPSNN 904
            + + VA+NR  W ++  K  +    S++
Sbjct: 535 PMLDSVATNRSKWEELHQKRLLASTASSS 563



 Score = 37.0 bits (84), Expect = 0.086
 Identities = 34/187 (18%), Positives = 79/187 (42%), Gaps = 24/187 (12%)

Query: 218 DRDRKILQLCGELYD--LDASSLQLKVLQYLQQETRASRCCLLLVSE------------D 263
           +R R +L++  +L++   D   +  K++   Q   +  RC +LL+ +            +
Sbjct: 26  ERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFE 85

Query: 264 NLQLSCKVIGDKVLGEEV---SFPLTGCLGQVVEDKKSIQLKDLTSEDVQ------QLQS 314
            +   C    +    E +   S+        + E   S  L    S+  Q      +   
Sbjct: 86  LMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQ 145

Query: 315 MLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTL 374
           + G  ++++LCVP+ + +  Q++ +A   N+L+G  F D D+ + +    +    + +T+
Sbjct: 146 ISGFHIRSVLCVPIWN-SNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTI 204

Query: 375 AFQKEQK 381
            + + +K
Sbjct: 205 MYDQVKK 211


>gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]
          Length = 489

 Score =  303 bits (776), Expect = 5e-82
 Identities = 167/456 (36%), Positives = 257/456 (56%), Gaps = 12/456 (2%)

Query: 455 DQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELV 514
           +  IA  VA+TG  +NI DAY  P F    D  +GF  R++LC PI N N ++IGVA+++
Sbjct: 28  NNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVL 87

Query: 515 NKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDE 574
           N+++G  F   D+ L  AF I+CG+ I ++++Y +V ++  +  +A +++ YH   S  E
Sbjct: 88  NRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAE 147

Query: 575 YTKLLHDGIQPVAAI---DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPT 631
             K     I  V+ +   D +F  F     SL  D    A L M  ++  +  +KID  T
Sbjct: 148 VDKFKAANIPLVSELAIDDIHFDDF-----SLDVDAMITAALRMFMELGMVQKFKIDYET 202

Query: 632 LARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDL 691
           L R+ L V+K YR   YHNW HAF+V    + +       + L ++EI A+ + C+CHDL
Sbjct: 203 LCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDL 262

Query: 692 DHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRML 751
           DHRGTNN+FQ  S S LA LY +  + +E HHF  A+ IL + G NIF + S K+Y  ++
Sbjct: 263 DHRGTNNAFQAKSGSALAQLYGT-SATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLM 321

Query: 752 DLMRDIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWK 810
            L++  ILATDL  +     +  ++   G YD N K H  +   +LMT+CDL   TK W+
Sbjct: 322 QLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWE 381

Query: 811 TTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDR-EKAYIPELQISFMEHIAMPIYKLLQ 868
            +R++AEL+  EFF QGD E+  +   P  + DR  K  +P LQ+ +++ I MP+Y+ L 
Sbjct: 382 ISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALV 441

Query: 869 DLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNN 904
            +  K   + + VA+NR  W ++  K  +    S++
Sbjct: 442 KVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSS 477



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 15/65 (23%), Positives = 37/65 (56%), Gaps = 1/65 (1%)

Query: 317 GCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAF 376
           G  ++++LCVP+ + +  Q++ +A   N+L+G  F D D+ + +    +    + +T+ +
Sbjct: 62  GFHIRSVLCVPIWN-SNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMY 120

Query: 377 QKEQK 381
            + +K
Sbjct: 121 DQVKK 125


>gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]
          Length = 875

 Score =  288 bits (737), Expect = 2e-77
 Identities = 214/718 (29%), Positives = 362/718 (50%), Gaps = 46/718 (6%)

Query: 218 DRDRKILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSED--NLQLSCKVIGD 274
           D+  ++L+L  ++   LD ++L  K+  ++     A R  L LV ED  N +     + D
Sbjct: 147 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 206

Query: 275 KVLG---EEVSFPLT------GCLGQVVEDKKSIQLKDLTSEDVQ---QLQSMLGCELQA 322
              G   EEVS          G +G V    + + +KD   ED +   ++  + G + Q+
Sbjct: 207 VAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKD-AYEDPRFNAEVDQITGYKTQS 265

Query: 323 MLCVPVISRATDQVVALACAFNKLEGD--LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQ 380
           +LC+P I    ++VV +A A NK  G+   FT++DE        +   VL +   ++   
Sbjct: 266 ILCMP-IKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSL 324

Query: 381 KLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN--ELVAKVF 438
                 Q LL +A  +F     + V+L++I     +    + C++F++D++  +  + VF
Sbjct: 325 LENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVF 384

Query: 439 DGGVVDDESYEIRIPADQGI-------AGHVATTGQILNIPDAYAHPLFYRGVDDSTGFR 491
                + E     +  +          A +V  T + LNIPD      F    +++    
Sbjct: 385 HMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVN 444

Query: 492 T---RNILCFPIKN-ENQEVIGVAELVNKINGPW-----FSKFDEDLATAFSIYCGISIA 542
               R++LC PIKN +  +VIGV +LVNK+         F++ DE    AF I+CG+ I 
Sbjct: 445 QQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQ 504

Query: 543 HSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKL--LHDGIQPVAAIDSNFASFTYTP 600
           ++ +Y+ V  A  +  +  E++ YH   +++E  +L  L   + P +A       F+++ 
Sbjct: 505 NTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVP-SAQTLKITDFSFSD 563

Query: 601 RSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYR-DPPYHNWMHAFSVSH 659
             L + +T++  + M  D+N + N+++    L R+ L VKK YR +  YHNW HAF+ + 
Sbjct: 564 FELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQ 623

Query: 660 FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM 719
             +   K  ++ N L D+EI AL I+ + HDLDHRG NNS+   S+  LA LY    S+M
Sbjct: 624 CMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH--SIM 681

Query: 720 ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL-RIFKDLQKMAE 778
           E HHF Q + ILN+ G  I    S ++Y+  L +++  ILATDLA ++ R  +  + + +
Sbjct: 682 EHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK 741

Query: 779 VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLE-KAMGNRP 837
             ++  +     L L +LMT+CDLS  TK W   ++IAEL+  EFF QGD E K +   P
Sbjct: 742 NQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEP 801

Query: 838 MEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHK 894
            ++M+REK   IP +Q+ F++ I + +Y+ L  +      L +    NR+ W  ++ +
Sbjct: 802 TDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 859


>gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]
          Length = 823

 Score =  288 bits (737), Expect = 2e-77
 Identities = 214/718 (29%), Positives = 362/718 (50%), Gaps = 46/718 (6%)

Query: 218 DRDRKILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSED--NLQLSCKVIGD 274
           D+  ++L+L  ++   LD ++L  K+  ++     A R  L LV ED  N +     + D
Sbjct: 95  DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 154

Query: 275 KVLG---EEVSFPLT------GCLGQVVEDKKSIQLKDLTSEDVQ---QLQSMLGCELQA 322
              G   EEVS          G +G V    + + +KD   ED +   ++  + G + Q+
Sbjct: 155 VAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKD-AYEDPRFNAEVDQITGYKTQS 213

Query: 323 MLCVPVISRATDQVVALACAFNKLEGD--LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQ 380
           +LC+P I    ++VV +A A NK  G+   FT++DE        +   VL +   ++   
Sbjct: 214 ILCMP-IKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSL 272

Query: 381 KLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN--ELVAKVF 438
                 Q LL +A  +F     + V+L++I     +    + C++F++D++  +  + VF
Sbjct: 273 LENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVF 332

Query: 439 DGGVVDDESYEIRIPADQGI-------AGHVATTGQILNIPDAYAHPLFYRGVDDSTGFR 491
                + E     +  +          A +V  T + LNIPD      F    +++    
Sbjct: 333 HMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVN 392

Query: 492 T---RNILCFPIKN-ENQEVIGVAELVNKINGPW-----FSKFDEDLATAFSIYCGISIA 542
               R++LC PIKN +  +VIGV +LVNK+         F++ DE    AF I+CG+ I 
Sbjct: 393 QQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQ 452

Query: 543 HSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKL--LHDGIQPVAAIDSNFASFTYTP 600
           ++ +Y+ V  A  +  +  E++ YH   +++E  +L  L   + P +A       F+++ 
Sbjct: 453 NTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVP-SAQTLKITDFSFSD 511

Query: 601 RSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYR-DPPYHNWMHAFSVSH 659
             L + +T++  + M  D+N + N+++    L R+ L VKK YR +  YHNW HAF+ + 
Sbjct: 512 FELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQ 571

Query: 660 FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM 719
             +   K  ++ N L D+EI AL I+ + HDLDHRG NNS+   S+  LA LY    S+M
Sbjct: 572 CMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH--SIM 629

Query: 720 ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL-RIFKDLQKMAE 778
           E HHF Q + ILN+ G  I    S ++Y+  L +++  ILATDLA ++ R  +  + + +
Sbjct: 630 EHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK 689

Query: 779 VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLE-KAMGNRP 837
             ++  +     L L +LMT+CDLS  TK W   ++IAEL+  EFF QGD E K +   P
Sbjct: 690 NQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEP 749

Query: 838 MEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHK 894
            ++M+REK   IP +Q+ F++ I + +Y+ L  +      L +    NR+ W  ++ +
Sbjct: 750 TDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 807


>gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]
          Length = 833

 Score =  288 bits (737), Expect = 2e-77
 Identities = 214/718 (29%), Positives = 362/718 (50%), Gaps = 46/718 (6%)

Query: 218 DRDRKILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSED--NLQLSCKVIGD 274
           D+  ++L+L  ++   LD ++L  K+  ++     A R  L LV ED  N +     + D
Sbjct: 105 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 164

Query: 275 KVLG---EEVSFPLT------GCLGQVVEDKKSIQLKDLTSEDVQ---QLQSMLGCELQA 322
              G   EEVS          G +G V    + + +KD   ED +   ++  + G + Q+
Sbjct: 165 VAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKD-AYEDPRFNAEVDQITGYKTQS 223

Query: 323 MLCVPVISRATDQVVALACAFNKLEGD--LFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQ 380
           +LC+P I    ++VV +A A NK  G+   FT++DE        +   VL +   ++   
Sbjct: 224 ILCMP-IKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSL 282

Query: 381 KLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN--ELVAKVF 438
                 Q LL +A  +F     + V+L++I     +    + C++F++D++  +  + VF
Sbjct: 283 LENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVF 342

Query: 439 DGGVVDDESYEIRIPADQGI-------AGHVATTGQILNIPDAYAHPLFYRGVDDSTGFR 491
                + E     +  +          A +V  T + LNIPD      F    +++    
Sbjct: 343 HMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVN 402

Query: 492 T---RNILCFPIKN-ENQEVIGVAELVNKINGPW-----FSKFDEDLATAFSIYCGISIA 542
               R++LC PIKN +  +VIGV +LVNK+         F++ DE    AF I+CG+ I 
Sbjct: 403 QQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQ 462

Query: 543 HSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKL--LHDGIQPVAAIDSNFASFTYTP 600
           ++ +Y+ V  A  +  +  E++ YH   +++E  +L  L   + P +A       F+++ 
Sbjct: 463 NTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVP-SAQTLKITDFSFSD 521

Query: 601 RSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYR-DPPYHNWMHAFSVSH 659
             L + +T++  + M  D+N + N+++    L R+ L VKK YR +  YHNW HAF+ + 
Sbjct: 522 FELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQ 581

Query: 660 FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM 719
             +   K  ++ N L D+EI AL I+ + HDLDHRG NNS+   S+  LA LY    S+M
Sbjct: 582 CMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCH--SIM 639

Query: 720 ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL-RIFKDLQKMAE 778
           E HHF Q + ILN+ G  I    S ++Y+  L +++  ILATDLA ++ R  +  + + +
Sbjct: 640 EHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK 699

Query: 779 VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLE-KAMGNRP 837
             ++  +     L L +LMT+CDLS  TK W   ++IAEL+  EFF QGD E K +   P
Sbjct: 700 NQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEP 759

Query: 838 MEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHK 894
            ++M+REK   IP +Q+ F++ I + +Y+ L  +      L +    NR+ W  ++ +
Sbjct: 760 TDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 817


>gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]
          Length = 853

 Score =  283 bits (725), Expect = 4e-76
 Identities = 217/806 (26%), Positives = 375/806 (46%), Gaps = 109/806 (13%)

Query: 223 ILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSEDN--LQLSCKVIG---DKV 276
           +L+L  ++ + ++   +  KVL+ L    +A RC L +  + N   +L+ ++     D V
Sbjct: 59  LLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSV 118

Query: 277 LGE-------EVSFPLT-GCLGQVVEDKKSIQLKDLTS--EDVQQLQSMLGCELQAMLCV 326
           L +       E+ FPL  G +G V + KK + ++D+            +   + + ML  
Sbjct: 119 LEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLAT 178

Query: 327 PVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCEC 386
           P+++     VVA+  A NKL G  FT EDE V     ++ +  L     +       CE 
Sbjct: 179 PIMNGK--DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLK---IYHLSYLHNCET 233

Query: 387 ---QALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNE----------- 432
              Q LL  A  +F  L D+     +     R   N E  SV LLD  +           
Sbjct: 234 RRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVL 293

Query: 433 ------------------LVAKVFDGGVVDDESYEIRIPADQ--------GIAGHVATTG 466
                             +  KV D  +   E  ++ IP           G+  +VA +G
Sbjct: 294 MGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKV-IPTPSADHWALASGLPSYVAESG 352

Query: 467 QILNIPDAYAHPLF--YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSK 524
            I NI +A A  +F    G  D +G+  +N+L  PI N+ +E++GVA   N+ +G  F +
Sbjct: 353 FICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDE 412

Query: 525 FDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD--- 581
            DE L  + + + G S+ ++  Y K+N+ + R  +A +M++YH+K   DE   +L     
Sbjct: 413 QDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRAR 472

Query: 582 -GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMAILSMLQDMNFINN 624
            G +P    +                     F ++     E D     + M  ++  +  
Sbjct: 473 LGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRK 532

Query: 625 YKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFI 684
           ++I    L RF   + KGYR   YHNW H F+V+   + L    +L +Y  D+E FA+  
Sbjct: 533 FQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVT 592

Query: 685 SCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSR 744
           + +CHD+DHRGTNN +Q+ S++ LA L+ S  S++ERHH      +L+    NI+ + +R
Sbjct: 593 AGLCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKFLLSEETLNIYQNLNR 650

Query: 745 KDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ-----------HHRLLL 793
           + ++ ++ LM   I+ATDLA + +     QK+ +   +  +K+              +++
Sbjct: 651 RQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVM 710

Query: 794 CLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDREK-AYIPEL 851
            ++MT+CDLS  TK W+   K+A L+  EF+ QGDLE+  +  +P+ MMDR K A +P+L
Sbjct: 711 AMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKL 770

Query: 852 QISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDE 911
           Q+ F++ +   +YK       +   +++R+ +NR+ W  ++ ++  +      +L+  +E
Sbjct: 771 QVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAK----VKALEEKEE 826

Query: 912 EYEVPDLDGTR------APINGCCSL 931
           E  V    GT       AP +  C +
Sbjct: 827 EERVAAKKGTEICNGGPAPKSSTCCI 852



 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 65/255 (25%), Positives = 120/255 (47%), Gaps = 29/255 (11%)

Query: 385 ECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN----ELVAKVFD- 439
           E  ALL++ +++   ++   V+ + ++     L  A+ CS+F+  Q     EL  ++F  
Sbjct: 55  ESTALLELVQDMQESINMERVVFK-VLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSV 113

Query: 440 --GGVVDD----ESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTR 493
               V++D       EI  P D G+ GHVA T +++N+ D    P F    D+ T ++T+
Sbjct: 114 QPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTK 173

Query: 494 NILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEA 553
           N+L  PI N  ++V+ V   VNK+NGP+F+  DED+   +       +  + LY K+   
Sbjct: 174 NMLATPIMN-GKDVVAVIMAVNKLNGPFFTSEDEDVFLKY-------LNFATLYLKIYHL 225

Query: 554 QYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRS-LPEDDTSMAI 612
            Y  +         +  ++  + +L          I+  F    YT R+ L  +  S+ +
Sbjct: 226 SYLHNCETRRGQVLLWSANKVFEEL--------TDIERQFHKAFYTVRAYLNCERYSVGL 277

Query: 613 LSMLQDMNFINNYKI 627
           L M ++  F + + +
Sbjct: 278 LDMTKEKEFFDVWSV 292


>gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]
          Length = 854

 Score =  282 bits (721), Expect = 1e-75
 Identities = 208/764 (27%), Positives = 360/764 (47%), Gaps = 99/764 (12%)

Query: 223 ILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSEDN--LQLSCKVIG---DKV 276
           +L+L  ++ + ++   +  KVL+ L    +A RC L +  + N   +L+ ++     D V
Sbjct: 59  LLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSV 118

Query: 277 LGE-------EVSFPLT-GCLGQVVEDKKSIQLKDLTS--EDVQQLQSMLGCELQAMLCV 326
           L +       E+ FPL  G +G V + KK + ++D+            +   + + ML  
Sbjct: 119 LEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLAT 178

Query: 327 PVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCEC 386
           P+++     VVA+  A NKL G  FT EDE V     ++ +  L     +       CE 
Sbjct: 179 PIMNGK--DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLK---IYHLSYLHNCET 233

Query: 387 ---QALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNE----------- 432
              Q LL  A  +F  L D+     +     R   N E  SV LLD  +           
Sbjct: 234 RRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVL 293

Query: 433 ------------------LVAKVFDGGVVDDESYEIRIPADQ--------GIAGHVATTG 466
                             +  KV D  +   E  ++ IP           G+  +VA +G
Sbjct: 294 MGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKV-IPTPSADHWALASGLPSYVAESG 352

Query: 467 QILNIPDAYAHPLF--YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSK 524
            I NI +A A  +F    G  D +G+  +N+L  PI N+ +E++GVA   N+ +G  F +
Sbjct: 353 FICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDE 412

Query: 525 FDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD--- 581
            DE L  + + + G S+ ++  Y K+N+ + R  +A +M++YH+K   DE   +L     
Sbjct: 413 QDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRAR 472

Query: 582 -GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMAILSMLQDMNFINN 624
            G +P    +                     F ++     E D     + M  ++  +  
Sbjct: 473 LGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRK 532

Query: 625 YKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFI 684
           ++I    L RF   + KGYR   YHNW H F+V+   + L    +L +Y  D+E FA+  
Sbjct: 533 FQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVT 592

Query: 685 SCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSR 744
           + +CHD+DHRGTNN +Q+ S++ LA L+ S  S++ERHH      +L+    NI+ + +R
Sbjct: 593 AGLCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKFLLSEETLNIYQNLNR 650

Query: 745 KDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ-----------HHRLLL 793
           + ++ ++ LM   I+ATDLA + +     QK+ +   +  +K+              +++
Sbjct: 651 RQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVM 710

Query: 794 CLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDREK-AYIPEL 851
            ++MT+CDLS  TK W+   K+A L+  EF+ QGDLE+  +  +P+ MMDR K A +P+L
Sbjct: 711 AMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKL 770

Query: 852 QISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKF 895
           Q+ F++ +   +YK       +   +++R+ +NR+ W  ++ ++
Sbjct: 771 QVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEY 814



 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 65/255 (25%), Positives = 120/255 (47%), Gaps = 29/255 (11%)

Query: 385 ECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN----ELVAKVFD- 439
           E  ALL++ +++   ++   V+ + ++     L  A+ CS+F+  Q     EL  ++F  
Sbjct: 55  ESTALLELVQDMQESINMERVVFK-VLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSV 113

Query: 440 --GGVVDD----ESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTR 493
               V++D       EI  P D G+ GHVA T +++N+ D    P F    D+ T ++T+
Sbjct: 114 QPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTK 173

Query: 494 NILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEA 553
           N+L  PI N  ++V+ V   VNK+NGP+F+  DED+   +       +  + LY K+   
Sbjct: 174 NMLATPIMN-GKDVVAVIMAVNKLNGPFFTSEDEDVFLKY-------LNFATLYLKIYHL 225

Query: 554 QYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRS-LPEDDTSMAI 612
            Y  +         +  ++  + +L          I+  F    YT R+ L  +  S+ +
Sbjct: 226 SYLHNCETRRGQVLLWSANKVFEEL--------TDIERQFHKAFYTVRAYLNCERYSVGL 277

Query: 613 LSMLQDMNFINNYKI 627
           L M ++  F + + +
Sbjct: 278 LDMTKEKEFFDVWSV 292


>gi|157364939 phosphodiesterase 6C [Homo sapiens]
          Length = 858

 Score =  259 bits (661), Expect = 1e-68
 Identities = 195/745 (26%), Positives = 342/745 (45%), Gaps = 97/745 (13%)

Query: 241 KVLQYLQQETRASRCCLLLVSEDN--LQLSCKVIG--------DKVLG--EEVSFPLT-G 287
           + LQ L    +A RC + L    N   +++ +++         D ++G  +EV FPL  G
Sbjct: 82  RALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIG 141

Query: 288 CLGQVVEDKKSIQLKDL--TSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNK 345
            +G     KK+  + D+   S     +    G   + +L  P++     +V+A+  A NK
Sbjct: 142 IVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIV--VGKEVLAVIMAVNK 199

Query: 346 LEGDLFTDEDEHVIQHCFHYTSTVLT---STLAFQKEQKLKCECQALLQVAKNLFTHLDD 402
           +    F+ +DE V     ++ S +L    ++  +  E +     Q L+  A  +F  L D
Sbjct: 200 VNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESR---RSQILMWSANKVFEELTD 256

Query: 403 VSVLLQEIITEARNLSNAEICSVFLLDQNELVA------------------KVFDGGVVD 444
           V     + +   R+  N E  S+ LLD  +                     K  DG  V+
Sbjct: 257 VERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVN 316

Query: 445 ---------DESYEIRI----PADQ-----GIAGHVATTGQILNIPDAYAHPLF--YRGV 484
                        EI++    PAD      G+  +VA  G I N+ +A A   F   +G 
Sbjct: 317 FYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGP 376

Query: 485 DDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHS 544
            D TG+  +N+L  PI N+ ++++GVA   N+ +G  F + DE +    + + G S+ ++
Sbjct: 377 VDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNT 436

Query: 545 LLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLH-------------DGIQPVAAIDS 591
             Y K+N+ + R  +A EM+M   K + +E   +L              +  Q VA +  
Sbjct: 437 DTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKE 496

Query: 592 NFAS--------FTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGY 643
           +           F ++   L E       + +  ++N +  +K+    L R+   V+KGY
Sbjct: 497 DLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGY 556

Query: 644 RDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVA 703
           R   YHNW H F+V    + L     L  Y  D+E FA+  +  CHD+DHRGTNN +Q+ 
Sbjct: 557 RAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMK 616

Query: 704 SKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDL 763
           S S LA L+ S  S++ERHH   +  +L     NIF + +++ ++ ++ L    I+ATDL
Sbjct: 617 STSPLARLHGS--SILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDL 674

Query: 764 AHHLRIFKDLQKMAE-----------VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTT 812
           A + +     QK+ +           + Y   +     +++ ++MT+CDLS  TK W+  
Sbjct: 675 ALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQ 734

Query: 813 RKIAELIYKEFFSQGDLEK-AMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQDL 870
            ++A ++  EF+ QGDLE+  +  +P+ MMDR K   +P+LQ+ F++ +   +YK     
Sbjct: 735 SQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRF 794

Query: 871 FPKAAELYERVASNREHWTKVSHKF 895
             +   +   + +NR  W  ++ ++
Sbjct: 795 HKEITPMLSGLQNNRVEWKSLADEY 819


>gi|170650674 phosphodiesterase 6A [Homo sapiens]
          Length = 860

 Score =  256 bits (653), Expect = 9e-68
 Identities = 188/717 (26%), Positives = 328/717 (45%), Gaps = 90/717 (12%)

Query: 257 LLLVSEDNLQLSCKVIGDKVLGEEVSFPLT-GCLGQVVEDKKSIQLKDLTSED---VQQL 312
           L  V +D +   C V+ D    +E+ FPL  G +G V   KK   + + T ED      +
Sbjct: 112 LFNVHKDAVLEDCLVMPD----QEIVFPLDMGIVGHVAHSKKIANVPN-TEEDEHFCDFV 166

Query: 313 QSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTS 372
             +   + + +L  P+++     VVA+  A NK++G  FT  DE ++    ++ + ++  
Sbjct: 167 DILTEYKTKNILASPIMNGK--DVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMK- 223

Query: 373 TLAFQKEQKLKCEC---QALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLD 429
              +       CE    Q LL     +F  L D+     + +   R   N +  SV LLD
Sbjct: 224 --VYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLD 281

Query: 430 QNELVA-----------------------------KVFDGGVVDDESYEI--RIPADQ-- 456
             +                                KV D  +   E  ++    P D   
Sbjct: 282 MTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWA 341

Query: 457 ---GIAGHVATTGQILNIPDAYAHPLFYRGVD--DSTGFRTRNILCFPIKNENQEVIGVA 511
              G+  +VA  G I NI +A A   F    +  D +G+  +N+L  PI N+ +E++GVA
Sbjct: 342 LVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVA 401

Query: 512 ELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVS 571
              N+ +G  F + DE L  + + + G S+ +   Y+ +N+ + R  +  +++ YH+K  
Sbjct: 402 TFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCD 461

Query: 572 DDEYTKLLHD----GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMA 611
           ++E  K+L      G +P    +   A                 F ++   L E +    
Sbjct: 462 NEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKC 521

Query: 612 ILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELT 671
            + M  ++  ++ + I    L RF   + KGYR   YHNW H F+V    + L    +L 
Sbjct: 522 GIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLK 581

Query: 672 NYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAIL 731
            Y  D+E  A+  +  CHD+DHRGTNN +Q+ S++ LA L+ S  S++ERHH      +L
Sbjct: 582 RYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKTLL 639

Query: 732 NTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ---- 787
                NIF + +R+ ++  + +M   I+ATDLA + +     QK+ +      ++Q    
Sbjct: 640 RDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQ 699

Query: 788 -------HHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPME 839
                     +++ ++MT+CDLS  TK W+   ++A L+  EF+ QGDLE+  +   P+ 
Sbjct: 700 YMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIP 759

Query: 840 MMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKF 895
           MMDR KA  +P+LQ+ F++ +   +YK       +   + + + +NR+ W  ++ ++
Sbjct: 760 MMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEY 816



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 81/302 (26%), Positives = 130/302 (43%), Gaps = 57/302 (18%)

Query: 345 KLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVS 404
           KL  DL   ++  V    +H  S++  S + F     L  + Q  LQ  K +F  +  + 
Sbjct: 31  KLISDLLGAKEAAVDFSNYHSPSSMEESEIIFD----LLRDFQENLQTEKCIFNVMKKLC 86

Query: 405 VLLQEIITEARNLSNAEICSVFLLDQN----ELVAKVFD---GGVVDD----ESYEIRIP 453
            LLQ           A+  S+F+        EL  ++F+     V++D       EI  P
Sbjct: 87  FLLQ-----------ADRMSLFMYRTRNGIAELATRLFNVHKDAVLEDCLVMPDQEIVFP 135

Query: 454 ADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAEL 513
            D GI GHVA + +I N+P+      F   VD  T ++T+NIL  PI N  ++V+ +   
Sbjct: 136 LDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILASPIMN-GKDVVAIIMA 194

Query: 514 VNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDD 573
           VNK++G  F+K DE+                +L K +N A         M +YH+    +
Sbjct: 195 VNKVDGSHFTKRDEE----------------ILLKYLNFANL------IMKVYHLSYLHN 232

Query: 574 EYTK----LLHDG---IQPVAAIDSNFASFTYTPRS-LPEDDTSMAILSMLQDMNFINNY 625
             T+    LL  G    + +  I+  F    YT R+ L  D  S+ +L M +   F + +
Sbjct: 233 CETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVW 292

Query: 626 KI 627
            +
Sbjct: 293 PV 294


>gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]
          Length = 575

 Score =  249 bits (636), Expect = 8e-66
 Identities = 142/474 (29%), Positives = 251/474 (52%), Gaps = 37/474 (7%)

Query: 457 GIAGHVATTGQILNIPDAYAHPLF--YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELV 514
           G+  +VA +G I NI +A A  +F    G  D +G+  +N+L  PI N+ +E++GVA   
Sbjct: 64  GLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFY 123

Query: 515 NKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDE 574
           N+ +G  F + DE L  + + + G S+ ++  Y K+N+ + R  +A +M++YH+K   DE
Sbjct: 124 NRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDE 183

Query: 575 YTKLLHD----GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMAILS 614
              +L      G +P    +                     F ++     E D     + 
Sbjct: 184 IQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQ 243

Query: 615 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 674
           M  ++  +  ++I    L RF   + KGYR   YHNW H F+V+   + L    +L +Y 
Sbjct: 244 MYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYY 303

Query: 675 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 734
            D+E FA+  + +CHD+DHRGTNN +Q+ S++ LA L+ S  S++ERHH      +L+  
Sbjct: 304 TDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKFLLSEE 361

Query: 735 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ------- 787
             NI+ + +R+ ++ ++ LM   I+ATDLA + +     QK+ +   +  +K+       
Sbjct: 362 TLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLS 421

Query: 788 ----HHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMD 842
                  +++ ++MT+CDLS  TK W+   K+A L+  EF+ QGDLE+  +  +P+ MMD
Sbjct: 422 LETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMD 481

Query: 843 REK-AYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKF 895
           R K A +P+LQ+ F++ +   +YK       +   +++R+ +NR+ W  ++ ++
Sbjct: 482 RNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEY 535



 Score = 31.2 bits (69), Expect = 4.7
 Identities = 14/67 (20%), Positives = 39/67 (58%), Gaps = 1/67 (1%)

Query: 317 GCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAF 376
           G  ++ +L +P++++  +++V +A  +N+ +G  F ++DE +++    +    + +T  +
Sbjct: 98  GWLIKNVLSMPIVNKK-EEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTY 156

Query: 377 QKEQKLK 383
            K  KL+
Sbjct: 157 DKMNKLE 163


>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
          Length = 386

 Score =  156 bits (395), Expect = 7e-38
 Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)

Query: 615 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 674
           M  D+  + ++ I+  TL R+   V   YR+ P+HN+ H F V+   Y +     L    
Sbjct: 71  MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 130

Query: 675 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 734
              +I  L  + +CHDLDH G NN++Q+ +++ LA  Y ++ S +E HH A A  IL   
Sbjct: 131 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 189

Query: 735 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 794
            CNIF +     ++++   M  +ILATD+A H  I    ++  E  +D +N++H  LL  
Sbjct: 190 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 248

Query: 795 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 854
           +L+  CD+S++ +  +      + + +E+F Q D EK+ G      MDR+K      QI 
Sbjct: 249 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 308

Query: 855 FMEHIAMPIYKLLQDLFPKAAEL 877
           F++ + +P+++ +  LFP   E+
Sbjct: 309 FIKFVLIPMFETVTKLFPMVEEI 331


>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
          Length = 386

 Score =  156 bits (395), Expect = 7e-38
 Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)

Query: 615 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 674
           M  D+  + ++ I+  TL R+   V   YR+ P+HN+ H F V+   Y +     L    
Sbjct: 71  MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 130

Query: 675 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 734
              +I  L  + +CHDLDH G NN++Q+ +++ LA  Y ++ S +E HH A A  IL   
Sbjct: 131 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 189

Query: 735 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 794
            CNIF +     ++++   M  +ILATD+A H  I    ++  E  +D +N++H  LL  
Sbjct: 190 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 248

Query: 795 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 854
           +L+  CD+S++ +  +      + + +E+F Q D EK+ G      MDR+K      QI 
Sbjct: 249 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 308

Query: 855 FMEHIAMPIYKLLQDLFPKAAEL 877
           F++ + +P+++ +  LFP   E+
Sbjct: 309 FIKFVLIPMFETVTKLFPMVEEI 331


>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
          Length = 567

 Score =  156 bits (395), Expect = 7e-38
 Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)

Query: 615 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 674
           M  D+  + ++ I+  TL R+   V   YR+ P+HN+ H F V+   Y +     L    
Sbjct: 252 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 311

Query: 675 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 734
              +I  L  + +CHDLDH G NN++Q+ +++ LA  Y ++ S +E HH A A  IL   
Sbjct: 312 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 370

Query: 735 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 794
            CNIF +     ++++   M  +ILATD+A H  I    ++  E  +D +N++H  LL  
Sbjct: 371 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 429

Query: 795 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 854
           +L+  CD+S++ +  +      + + +E+F Q D EK+ G      MDR+K      QI 
Sbjct: 430 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 489

Query: 855 FMEHIAMPIYKLLQDLFPKAAEL 877
           F++ + +P+++ +  LFP   E+
Sbjct: 490 FIKFVLIPMFETVTKLFPMVEEI 512


>gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]
          Length = 552

 Score =  156 bits (395), Expect = 7e-38
 Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)

Query: 615 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 674
           M  D+  + ++ I+  TL R+   V   YR+ P+HN+ H F V+   Y +     L    
Sbjct: 237 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 296

Query: 675 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 734
              +I  L  + +CHDLDH G NN++Q+ +++ LA  Y ++ S +E HH A A  IL   
Sbjct: 297 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 355

Query: 735 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 794
            CNIF +     ++++   M  +ILATD+A H  I    ++  E  +D +N++H  LL  
Sbjct: 356 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 414

Query: 795 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 854
           +L+  CD+S++ +  +      + + +E+F Q D EK+ G      MDR+K      QI 
Sbjct: 415 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 474

Query: 855 FMEHIAMPIYKLLQDLFPKAAEL 877
           F++ + +P+++ +  LFP   E+
Sbjct: 475 FIKFVLIPMFETVTKLFPMVEEI 497


>gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens]
          Length = 526

 Score =  156 bits (395), Expect = 7e-38
 Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)

Query: 615 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 674
           M  D+  + ++ I+  TL R+   V   YR+ P+HN+ H F V+   Y +     L    
Sbjct: 211 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 270

Query: 675 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 734
              +I  L  + +CHDLDH G NN++Q+ +++ LA  Y ++ S +E HH A A  IL   
Sbjct: 271 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 329

Query: 735 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 794
            CNIF +     ++++   M  +ILATD+A H  I    ++  E  +D +N++H  LL  
Sbjct: 330 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 388

Query: 795 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 854
           +L+  CD+S++ +  +      + + +E+F Q D EK+ G      MDR+K      QI 
Sbjct: 389 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 448

Query: 855 FMEHIAMPIYKLLQDLFPKAAEL 877
           F++ + +P+++ +  LFP   E+
Sbjct: 449 FIKFVLIPMFETVTKLFPMVEEI 471


>gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens]
          Length = 376

 Score =  156 bits (395), Expect = 7e-38
 Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)

Query: 615 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 674
           M  D+  + ++ I+  TL R+   V   YR+ P+HN+ H F V+   Y +     L    
Sbjct: 61  MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 120

Query: 675 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 734
              +I  L  + +CHDLDH G NN++Q+ +++ LA  Y ++ S +E HH A A  IL   
Sbjct: 121 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 179

Query: 735 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 794
            CNIF +     ++++   M  +ILATD+A H  I    ++  E  +D +N++H  LL  
Sbjct: 180 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 238

Query: 795 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 854
           +L+  CD+S++ +  +      + + +E+F Q D EK+ G      MDR+K      QI 
Sbjct: 239 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 298

Query: 855 FMEHIAMPIYKLLQDLFPKAAEL 877
           F++ + +P+++ +  LFP   E+
Sbjct: 299 FIKFVLIPMFETVTKLFPMVEEI 321


>gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens]
          Length = 386

 Score =  156 bits (395), Expect = 7e-38
 Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)

Query: 615 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 674
           M  D+  + ++ I+  TL R+   V   YR+ P+HN+ H F V+   Y +     L    
Sbjct: 71  MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 130

Query: 675 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 734
              +I  L  + +CHDLDH G NN++Q+ +++ LA  Y ++ S +E HH A A  IL   
Sbjct: 131 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 189

Query: 735 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 794
            CNIF +     ++++   M  +ILATD+A H  I    ++  E  +D +N++H  LL  
Sbjct: 190 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 248

Query: 795 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 854
           +L+  CD+S++ +  +      + + +E+F Q D EK+ G      MDR+K      QI 
Sbjct: 249 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 308

Query: 855 FMEHIAMPIYKLLQDLFPKAAEL 877
           F++ + +P+++ +  LFP   E+
Sbjct: 309 FIKFVLIPMFETVTKLFPMVEEI 331


>gi|48762740 phosphodiesterase 9A isoform l [Homo sapiens]
          Length = 491

 Score =  156 bits (395), Expect = 7e-38
 Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)

Query: 615 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 674
           M  D+  + ++ I+  TL R+   V   YR+ P+HN+ H F V+   Y +     L    
Sbjct: 176 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 235

Query: 675 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 734
              +I  L  + +CHDLDH G NN++Q+ +++ LA  Y ++ S +E HH A A  IL   
Sbjct: 236 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 294

Query: 735 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 794
            CNIF +     ++++   M  +ILATD+A H  I    ++  E  +D +N++H  LL  
Sbjct: 295 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 353

Query: 795 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 854
           +L+  CD+S++ +  +      + + +E+F Q D EK+ G      MDR+K      QI 
Sbjct: 354 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 413

Query: 855 FMEHIAMPIYKLLQDLFPKAAEL 877
           F++ + +P+++ +  LFP   E+
Sbjct: 414 FIKFVLIPMFETVTKLFPMVEEI 436


>gi|48762738 phosphodiesterase 9A isoform k [Homo sapiens]
          Length = 459

 Score =  156 bits (395), Expect = 7e-38
 Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)

Query: 615 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 674
           M  D+  + ++ I+  TL R+   V   YR+ P+HN+ H F V+   Y +     L    
Sbjct: 144 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 203

Query: 675 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 734
              +I  L  + +CHDLDH G NN++Q+ +++ LA  Y ++ S +E HH A A  IL   
Sbjct: 204 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 262

Query: 735 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 794
            CNIF +     ++++   M  +ILATD+A H  I    ++  E  +D +N++H  LL  
Sbjct: 263 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 321

Query: 795 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 854
           +L+  CD+S++ +  +      + + +E+F Q D EK+ G      MDR+K      QI 
Sbjct: 322 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 381

Query: 855 FMEHIAMPIYKLLQDLFPKAAEL 877
           F++ + +P+++ +  LFP   E+
Sbjct: 382 FIKFVLIPMFETVTKLFPMVEEI 404


>gi|48762736 phosphodiesterase 9A isoform j [Homo sapiens]
          Length = 376

 Score =  156 bits (395), Expect = 7e-38
 Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)

Query: 615 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 674
           M  D+  + ++ I+  TL R+   V   YR+ P+HN+ H F V+   Y +     L    
Sbjct: 61  MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 120

Query: 675 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 734
              +I  L  + +CHDLDH G NN++Q+ +++ LA  Y ++ S +E HH A A  IL   
Sbjct: 121 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 179

Query: 735 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 794
            CNIF +     ++++   M  +ILATD+A H  I    ++  E  +D +N++H  LL  
Sbjct: 180 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 238

Query: 795 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 854
           +L+  CD+S++ +  +      + + +E+F Q D EK+ G      MDR+K      QI 
Sbjct: 239 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 298

Query: 855 FMEHIAMPIYKLLQDLFPKAAEL 877
           F++ + +P+++ +  LFP   E+
Sbjct: 299 FIKFVLIPMFETVTKLFPMVEEI 321


>gi|48762734 phosphodiesterase 9A isoform i [Homo sapiens]
          Length = 433

 Score =  156 bits (395), Expect = 7e-38
 Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)

Query: 615 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 674
           M  D+  + ++ I+  TL R+   V   YR+ P+HN+ H F V+   Y +     L    
Sbjct: 118 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 177

Query: 675 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 734
              +I  L  + +CHDLDH G NN++Q+ +++ LA  Y ++ S +E HH A A  IL   
Sbjct: 178 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 236

Query: 735 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 794
            CNIF +     ++++   M  +ILATD+A H  I    ++  E  +D +N++H  LL  
Sbjct: 237 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 295

Query: 795 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 854
           +L+  CD+S++ +  +      + + +E+F Q D EK+ G      MDR+K      QI 
Sbjct: 296 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 355

Query: 855 FMEHIAMPIYKLLQDLFPKAAEL 877
           F++ + +P+++ +  LFP   E+
Sbjct: 356 FIKFVLIPMFETVTKLFPMVEEI 378


>gi|48762732 phosphodiesterase 9A isoform h [Homo sapiens]
          Length = 507

 Score =  156 bits (395), Expect = 7e-38
 Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)

Query: 615 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 674
           M  D+  + ++ I+  TL R+   V   YR+ P+HN+ H F V+   Y +     L    
Sbjct: 192 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 251

Query: 675 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 734
              +I  L  + +CHDLDH G NN++Q+ +++ LA  Y ++ S +E HH A A  IL   
Sbjct: 252 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 310

Query: 735 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 794
            CNIF +     ++++   M  +ILATD+A H  I    ++  E  +D +N++H  LL  
Sbjct: 311 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 369

Query: 795 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 854
           +L+  CD+S++ +  +      + + +E+F Q D EK+ G      MDR+K      QI 
Sbjct: 370 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 429

Query: 855 FMEHIAMPIYKLLQDLFPKAAEL 877
           F++ + +P+++ +  LFP   E+
Sbjct: 430 FIKFVLIPMFETVTKLFPMVEEI 452


>gi|48762730 phosphodiesterase 9A isoform g [Homo sapiens]
          Length = 386

 Score =  156 bits (395), Expect = 7e-38
 Identities = 82/263 (31%), Positives = 140/263 (53%), Gaps = 2/263 (0%)

Query: 615 MLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL 674
           M  D+  + ++ I+  TL R+   V   YR+ P+HN+ H F V+   Y +     L    
Sbjct: 71  MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 130

Query: 675 EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTH 734
              +I  L  + +CHDLDH G NN++Q+ +++ LA  Y ++ S +E HH A A  IL   
Sbjct: 131 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRY-NDISPLENHHCAVAFQILAEP 189

Query: 735 GCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLC 794
            CNIF +     ++++   M  +ILATD+A H  I    ++  E  +D +N++H  LL  
Sbjct: 190 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME-NFDYSNEEHMTLLKM 248

Query: 795 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQIS 854
           +L+  CD+S++ +  +      + + +E+F Q D EK+ G      MDR+K      QI 
Sbjct: 249 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIG 308

Query: 855 FMEHIAMPIYKLLQDLFPKAAEL 877
           F++ + +P+++ +  LFP   E+
Sbjct: 309 FIKFVLIPMFETVTKLFPMVEEI 331


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,868,549
Number of Sequences: 37866
Number of extensions: 1531215
Number of successful extensions: 6978
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 75
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 6654
Number of HSP's gapped (non-prelim): 142
length of query: 934
length of database: 18,247,518
effective HSP length: 112
effective length of query: 822
effective length of database: 14,006,526
effective search space: 11513364372
effective search space used: 11513364372
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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