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Search of human proteins with 219689123
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|219689123 pleckstrin homology domain containing, family A
member 5 isoform 2 [Homo sapiens]
(1105 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|219689123 pleckstrin homology domain containing, family A mem... 2227 0.0
gi|19923493 pleckstrin homology domain containing, family A memb... 1897 0.0
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 416 e-116
gi|239047795 pleckstrin homology domain containing, family A mem... 356 6e-98
gi|238859653 pleckstrin homology domain containing family A memb... 143 8e-34
gi|238859651 pleckstrin homology domain containing family A memb... 143 8e-34
gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Ho... 77 1e-13
gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [... 71 6e-12
gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [... 71 6e-12
gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [H... 71 6e-12
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 55 5e-07
gi|50980301 myosin phosphatase-Rho interacting protein isoform 2... 55 5e-07
gi|50980307 myosin phosphatase-Rho interacting protein isoform 1... 55 5e-07
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 55 5e-07
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 54 6e-07
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 54 1e-06
gi|188497618 connector enhancer of kinase suppressor of Ras 1 [H... 52 3e-06
gi|24432056 hypothetical protein LOC144717 [Homo sapiens] 52 4e-06
gi|33356174 pinin, desmosome associated protein [Homo sapiens] 51 5e-06
gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sap... 50 2e-05
gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapi... 50 2e-05
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 49 2e-05
gi|50234893 pleckstrin homology domain containing, family A (pho... 48 4e-05
gi|31377720 pleckstrin homology domain containing, family A (pho... 48 4e-05
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 48 4e-05
gi|217416392 pleckstrin homology domain containing, family H (wi... 48 6e-05
gi|187608516 centaurin, beta 2 [Homo sapiens] 48 6e-05
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] 48 6e-05
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 47 8e-05
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 47 1e-04
>gi|219689123 pleckstrin homology domain containing, family A member 5
isoform 2 [Homo sapiens]
Length = 1105
Score = 2227 bits (5770), Expect = 0.0
Identities = 1105/1105 (100%), Positives = 1105/1105 (100%)
Query: 1 MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNA 60
MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNA
Sbjct: 1 MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNA 60
Query: 61 PVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSED 120
PVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSED
Sbjct: 61 PVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSED 120
Query: 121 HINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTK 180
HINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTK
Sbjct: 121 HINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTK 180
Query: 181 ETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNS 240
ETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNS
Sbjct: 181 ETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNS 240
Query: 241 LPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRT 300
LPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRT
Sbjct: 241 LPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRT 300
Query: 301 NSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTR 360
NSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTR
Sbjct: 301 NSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTR 360
Query: 361 PESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPK 420
PESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPK
Sbjct: 361 PESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPK 420
Query: 421 TMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKH 480
TMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKH
Sbjct: 421 TMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKH 480
Query: 481 VYVPDRRSVPAGLTLQSVSPQSLQGKTMKENEPIITMVHTMIENSALRPQLYQQFLRQKS 540
VYVPDRRSVPAGLTLQSVSPQSLQGKTMKENEPIITMVHTMIENSALRPQLYQQFLRQKS
Sbjct: 481 VYVPDRRSVPAGLTLQSVSPQSLQGKTMKENEPIITMVHTMIENSALRPQLYQQFLRQKS 540
Query: 541 KISLYCLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQA 600
KISLYCLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQA
Sbjct: 541 KISLYCLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQA 600
Query: 601 LLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDV 660
LLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDV
Sbjct: 601 LLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDV 660
Query: 661 TVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGMIGSKPFST 720
TVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGMIGSKPFST
Sbjct: 661 TVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGMIGSKPFST 720
Query: 721 VKYKNEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQ 780
VKYKNEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQ
Sbjct: 721 VKYKNEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQ 780
Query: 781 GYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPP 840
GYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPP
Sbjct: 781 GYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPP 840
Query: 841 RAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRR 900
RAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRR
Sbjct: 841 RAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRR 900
Query: 901 HQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPD 960
HQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPD
Sbjct: 901 HQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPD 960
Query: 961 HETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMP 1020
HETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMP
Sbjct: 961 HETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMP 1020
Query: 1021 EDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSP 1080
EDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSP
Sbjct: 1021 EDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSP 1080
Query: 1081 SPESSASPVPSTQPQLTEGSHFMCV 1105
SPESSASPVPSTQPQLTEGSHFMCV
Sbjct: 1081 SPESSASPVPSTQPQLTEGSHFMCV 1105
>gi|19923493 pleckstrin homology domain containing, family A member 5
isoform 1 [Homo sapiens]
Length = 1116
Score = 1897 bits (4915), Expect = 0.0
Identities = 981/1110 (88%), Positives = 986/1110 (88%), Gaps = 107/1110 (9%)
Query: 1 MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNA 60
MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNA
Sbjct: 109 MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNA 168
Query: 61 PVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSED 120
PVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSED
Sbjct: 169 PVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSED 228
Query: 121 HINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTK 180
HINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTK
Sbjct: 229 HINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTK 288
Query: 181 ETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNS 240
ETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNS
Sbjct: 289 ETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNS 348
Query: 241 LPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRT 300
LPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRT
Sbjct: 349 LPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRT 408
Query: 301 NSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTR 360
NSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTR
Sbjct: 409 NSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTR 468
Query: 361 PESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPK 420
PESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPK
Sbjct: 469 PESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPK 528
Query: 421 TMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKH 480
TMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKH
Sbjct: 529 TMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKH 588
Query: 481 VYVPDRRSVPAGLTLQSVSPQSLQGKTMKENEPIITMVHTMIENSALRPQLYQQFLRQKS 540
VYVPDRRSVPAGLTLQSVSPQSLQGKT
Sbjct: 589 VYVPDRRSVPAGLTLQSVSPQSLQGKT--------------------------------- 615
Query: 541 KISLYCLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQA 600
LSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQA
Sbjct: 616 ------LSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQA 669
Query: 601 LLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDV 660
LLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDV
Sbjct: 670 LLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDV 729
Query: 661 TVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQR-----GMIGS 715
TVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQR GMIGS
Sbjct: 730 TVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGS 789
Query: 716 KPFSTVKYKNEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKK 775
KPFSTVKYKNE P + +P + D S
Sbjct: 790 KPFSTVKYKNEG----------PDYRLYKSEPELTTVAEVDES----------------- 822
Query: 776 MYQVQGYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPV 835
NG KSEP V+E+ ETSVVKGSHFPV
Sbjct: 823 ---------NGEE--------KSEP----VSEI---------------ETSVVKGSHFPV 846
Query: 836 GVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQM 895
GVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQM
Sbjct: 847 GVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQM 906
Query: 896 ERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIREN 955
ERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIREN
Sbjct: 907 ERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIREN 966
Query: 956 DVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERN 1015
DVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERN
Sbjct: 967 DVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERN 1026
Query: 1016 KDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAV 1075
KDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAV
Sbjct: 1027 KDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAV 1086
Query: 1076 KSLSPSPESSASPVPSTQPQLTEGSHFMCV 1105
KSLSPSPESSASPVPSTQPQLTEGSHFMCV
Sbjct: 1087 KSLSPSPESSASPVPSTQPQLTEGSHFMCV 1116
>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
sapiens]
Length = 1048
Score = 416 bits (1070), Expect = e-116
Identities = 354/1151 (30%), Positives = 542/1151 (47%), Gaps = 169/1151 (14%)
Query: 1 MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNA 60
M+++ +RP + ++ N+N+ S+ V P P R +R ++K FGKRS+S+KRNPNA
Sbjct: 1 MSNKTGGKRPATTNSDIPNHNMVSE--VPPERPSVRATRTARKAVAFGKRSHSMKRNPNA 58
Query: 61 PVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSED 120
PV + GWL+KQ S+G+K W KRWFVL D CLFYY+DEKEE ILGSI L SF++A + D
Sbjct: 59 PVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSD 118
Query: 121 HINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRV---------DK 171
+I+RK+ FKA H +RTY+F ++ +E E W++AM +AA VQ P ++ +K
Sbjct: 119 NISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEK 178
Query: 172 ITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLT 231
SEN P + + P H L KPE + + + + EK E+ +K+ P
Sbjct: 179 PDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKE----PPV 234
Query: 232 KINSVKLNSLP-----SEYESGSACPAQTVHYRPIN----LSSSENKIVNVSLADLRGGN 282
K N + P S Y G P N S S D G
Sbjct: 235 KANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGG 294
Query: 283 RPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQI 342
+ P T D++ QR +SM QL+QW+ +++G E+ R + + R +P +
Sbjct: 295 HRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPY 354
Query: 343 MARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGA-EEKRRSMRD--DTMWQLYEWQ 399
++YP+ Y+ P RPESICS+ +D+ P A E+KR + R+ +QL EW+
Sbjct: 355 SSQYPDDYQYYPPG--VRPESICSM--PAYDRISPPWALEDKRHAFRNGGGPAYQLREWK 410
Query: 400 QRQFYNKQST---LPRHS----------TLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQ 446
+ Y +Q +P S SS +++ ++ HS+P SPS GS + +
Sbjct: 411 EPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRS-HSVPRSPSQGSYSRAR 469
Query: 447 GYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGK 506
YSP V SP R + R + YV RRS+ + V P
Sbjct: 470 IYSP-------VRSPSARFERLPPRSEDIYADPAAYVM-RRSISS----PKVPPY----- 512
Query: 507 TMKENEPIITMVHTMIENSALRPQLYQQFLRQKSKISLYCLSQDEGRGTLYKYRPEEVDI 566
P++++ L YK ++
Sbjct: 513 ----------------------PEVFRDSLH------------------TYKLNEQDT-- 530
Query: 567 DAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRD 626
D L +LCEQ+KVV + +QQL EK +LE AL+ QE+EM PA + + ++D
Sbjct: 531 DKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLRHKKD 590
Query: 627 DLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQR 686
LQN L++ ELS+AT L + EY+ LE +V+ + + EQL+ + T++ + R
Sbjct: 591 SLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHDDLWEQLN----LDTQNEVLNR 646
Query: 687 AQIQKELWRIQDVMEGLSKHKQQRGMIGSKPFSTVKYKNEEEEVVPPRPPLPRSYDFTEQ 746
QIQKE+WRIQDVMEGL K+ RG T K+ R L S ++
Sbjct: 647 -QIQKEIWRIQDVMEGLRKNNPSRGT------DTAKH----------RGGLGPSATYSSN 689
Query: 747 PPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQGYPRNGSHCGP--DYRLYKSEPELTT 804
P P SS+ L P L QG P P +Y K +P T
Sbjct: 690 SPASPL----SSASLTSPLSPFSLVSGS-----QGSPTKPGSNEPKANYEQSKKDPHQTL 740
Query: 805 VAEV--DESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTK 862
+ D S + E +E + ++ K VGVVPPR KSPT + T ++ V +
Sbjct: 741 PLDTPRDISLVPTRQEVEAEKQAALNK-----VGVVPPRTKSPTDDEVTPSAVVRRNASG 795
Query: 863 KMMDLRT-ERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVIGASDQ 921
L + ERP+SAV + +M+VEEQ++R+RRHQ +REK++ L +
Sbjct: 796 LTNGLSSQERPKSAV----FPGEGKVKMSVEEQIDRMRRHQSGSMREKRRSLQL----PA 847
Query: 922 SPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPD------HETPATEIVQLK--E 973
SP PS P R R E+D + E ++ + +ETP EI +L+ E
Sbjct: 848 SPAPDPS---PRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPREEIARLRKME 904
Query: 974 TEPQ--NVDFSKELKKTENISY-EMLFEPEPN-GVNSVEMMDKERNKDKMPEDVTFSPQD 1029
EPQ +VD +KEL + + E + EP+ ++ E+ +K++ +++ + S
Sbjct: 905 LEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQ 964
Query: 1030 ETQTANHKPEEHPEENTKNSVDEQEETV-ISYESTPEVSRGNQTMAVKSLSPSPESS-AS 1087
+++++ + EQE+ + IS E SR + ++V+ +PSP +S AS
Sbjct: 965 NVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPAS 1024
Query: 1088 PVPSTQPQLTE 1098
P P P +E
Sbjct: 1025 PAPPANPLSSE 1035
>gi|239047795 pleckstrin homology domain containing, family A member
7 [Homo sapiens]
Length = 1121
Score = 356 bits (914), Expect = 6e-98
Identities = 296/928 (31%), Positives = 436/928 (46%), Gaps = 131/928 (14%)
Query: 1 MTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNA 60
M+ +++ +RP SM++E S S P + ++S KVH+FGKR +I+RNPN
Sbjct: 107 MSKQDRNQRPSSMVSETSTAGTASTLEAKPGPKI---IKSSSKVHSFGKRDQAIRRNPNV 163
Query: 61 PVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSED 120
PVV RGWL+KQDS+GM+LWK+RWFVL+D CLFYY+D +EE +LGSI LPS+ I+ + ED
Sbjct: 164 PVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPED 223
Query: 121 HINRKYAFKAAHPNMR-------------------TYYFCTDTGKEMELWMKAMLDAALV 161
I+RKY+FKA H MR TYYF DT ++M W++AM AA V
Sbjct: 224 RISRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQV 283
Query: 162 QTEP-VKR-VDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIE--EKKALEAE 217
+ +KR ++K+ + P + + P + ++ I E++ E E
Sbjct: 284 LSRSSLKRDMEKVERQAVPQANHTESCHECGRVGPGHTRDCPHRGHDDIVNFERQEQEGE 343
Query: 218 KYGFQKDGQDRPLT-KINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLA 276
+Y Q+D PL K + K S S E + R + + A
Sbjct: 344 QYRSQRD----PLEGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKNGMLPA 399
Query: 277 DLRGGNRPNTG------PLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQT 330
G + TG P T ++ QR +++ Q+E W + QKG ++R + QT
Sbjct: 400 SYGPGEQNGTGGYQRAFPPRTNPEKHSQRKSNLAQVEHWARAQKG-----DSRSLPLDQT 454
Query: 331 LPRNMPSHRAQIMARYPEGYRTLPRN-------SKTRPESICSVTPSTHDKTLG-PGAEE 382
LPR P +PE Y+TLP++ S P ++ S D+ + E
Sbjct: 455 LPRQGPGQSLS----FPENYQTLPKSTRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSE 510
Query: 383 KRRSMRDDTMWQLYEWQQRQ-FYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTS----P 437
+RR+ RD T+WQLYEWQQRQ F + T P L SP+ ++M +P S P
Sbjct: 511 ERRAHRDGTVWQLYEWQQRQQFRHGSPTAP--ICLGSPEFTDQGRSRSMLEVPRSISVPP 568
Query: 438 SHGSI---AAYQGYSPQRTY----RSEVSSPIQRGDVTID-----RRHRAHHPKHVYVPD 485
S I + + P+R + R V P QR V I RR R H K+ D
Sbjct: 569 SPSDIPPPGPPRVFPPRRPHTPAERVTVKPPDQRRSVDISLGDSPRRARGHAVKNSSHVD 628
Query: 486 RRSVPA-GLTLQSVSPQSLQGKTMKENEPIITMVHTMIENSALRPQLYQQFLRQKSKISL 544
RRS+P+ G +VS SL GK+ + Y Q + + L
Sbjct: 629 RRSMPSMGYMTHTVSAPSLHGKSADDT--------------------YLQLKKDLEYLDL 668
Query: 545 YCLSQDEGRG-TLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLS 603
+D + +L + E D D KLS CEQD+V+ LE+K++ L + K LE L
Sbjct: 669 KMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALKENKDQLESVLEV 728
Query: 604 ASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVT 663
+++E + D P ++ + Q+ LQ L+ ELSR + E+E AW EY KLE DV
Sbjct: 729 LHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLKLENDVEQL 788
Query: 664 RNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGMIGSKPFSTVKY 723
+ +QEQ Q +++QIQK+LWRI+DV GLS +K+ ++
Sbjct: 789 KQTLQEQHRRAFFFQ------EKSQIQKDLWRIEDVTAGLSANKENFRIL------VESV 836
Query: 724 KNEEEEVVP--PRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMY-QVQ 780
KN E + VP P PP+P S +E P PP PS +S PV P E +++ Q+Q
Sbjct: 837 KNPERKTVPLFPHPPVP-SLSTSESKP--PPQPSPPTS-------PVRTPLEVRLFPQLQ 886
Query: 781 GYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPP 840
Y H P R S + T A+ + P+ E+ + + P
Sbjct: 887 TYVPYRPH-PPQLRKVTSPLQSPTKAKPKVEDEAPPRPPLPELYSPEDQ----------P 935
Query: 841 RAKSPTPESSTIASYVTLRKTKKMMDLR 868
A P P +TI + ++R K+ D R
Sbjct: 936 PAVPPLPREATIIRHTSVRGLKRQSDER 963
>gi|238859653 pleckstrin homology domain containing family A member
4 isoform 2 [Homo sapiens]
Length = 583
Score = 143 bits (361), Expect = 8e-34
Identities = 69/147 (46%), Positives = 101/147 (68%), Gaps = 3/147 (2%)
Query: 9 RPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWL 68
RP S ++ AS+ + S ++ +SP + +RA K+H FGKR N+++R+PN PV RGWL
Sbjct: 5 RPRSSLSLASSASTIS--SLSSLSPK-KPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWL 61
Query: 69 YKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAF 128
+KQDS+G++LWK+RWFVLS CLFYY+D +EE +LGS+LLPS+ I R++ F
Sbjct: 62 HKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTF 121
Query: 129 KAAHPNMRTYYFCTDTGKEMELWMKAM 155
A HP MRTY DT +++ W++A+
Sbjct: 122 TAEHPGMRTYVLAADTLEDLRGWLRAL 148
Score = 68.6 bits (166), Expect = 3e-11
Identities = 44/142 (30%), Positives = 70/142 (49%), Gaps = 7/142 (4%)
Query: 562 EEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTV 621
+ ++ D L++LC QD+++ L+E++ Q +EK LE AL Q++ A
Sbjct: 335 QSLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRA 394
Query: 622 VLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTES 681
++ LQ+ L+S L T E ER W Y LE ++ R + E L HLG Q
Sbjct: 395 WGRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETL-EYLLHLGSPQ--- 450
Query: 682 AGIQRAQIQKELWRIQDVMEGL 703
R Q++LW ++D + GL
Sbjct: 451 ---DRVSAQQQLWMVEDTLAGL 469
>gi|238859651 pleckstrin homology domain containing family A member
4 isoform 1 [Homo sapiens]
Length = 779
Score = 143 bits (361), Expect = 8e-34
Identities = 69/147 (46%), Positives = 101/147 (68%), Gaps = 3/147 (2%)
Query: 9 RPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWL 68
RP S ++ AS+ + S ++ +SP + +RA K+H FGKR N+++R+PN PV RGWL
Sbjct: 5 RPRSSLSLASSASTIS--SLSSLSPK-KPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWL 61
Query: 69 YKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAF 128
+KQDS+G++LWK+RWFVLS CLFYY+D +EE +LGS+LLPS+ I R++ F
Sbjct: 62 HKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTF 121
Query: 129 KAAHPNMRTYYFCTDTGKEMELWMKAM 155
A HP MRTY DT +++ W++A+
Sbjct: 122 TAEHPGMRTYVLAADTLEDLRGWLRAL 148
Score = 68.6 bits (166), Expect = 3e-11
Identities = 44/142 (30%), Positives = 70/142 (49%), Gaps = 7/142 (4%)
Query: 562 EEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTV 621
+ ++ D L++LC QD+++ L+E++ Q +EK LE AL Q++ A
Sbjct: 360 QSLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRA 419
Query: 622 VLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTES 681
++ LQ+ L+S L T E ER W Y LE ++ R + E L HLG Q
Sbjct: 420 WGRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETL-EYLLHLGSPQ--- 475
Query: 682 AGIQRAQIQKELWRIQDVMEGL 703
R Q++LW ++D + GL
Sbjct: 476 ---DRVSAQQQLWMVEDTLAGL 494
Score = 30.4 bits (67), Expect = 9.7
Identities = 12/22 (54%), Positives = 18/22 (81%)
Query: 882 AESTRPRMTVEEQMERIRRHQQ 903
A RPRM+ +EQ+ER+RR+Q+
Sbjct: 582 APVARPRMSAQEQLERMRRNQE 603
>gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Homo
sapiens]
Length = 1034
Score = 76.6 bits (187), Expect = 1e-13
Identities = 53/170 (31%), Positives = 79/170 (46%), Gaps = 10/170 (5%)
Query: 23 TSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQD---STGMKLW 79
T+ Y S + S+ K GK I GWL+K+ S + W
Sbjct: 532 TTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKW 591
Query: 80 KKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYY 139
KK WFVL D L++Y +E++E G I LP F+I +KYAFKA HP ++++Y
Sbjct: 592 KKYWFVLKDASLYWYINEEDEKAEGFISLPEFKI---DRASECRKKYAFKACHPKIKSFY 648
Query: 140 FCTDTGKEMELWMKA--MLDAALVQTEPVKRVDKITSENAPTKETNNIPN 187
F + +M W+ ML A + E +K+ SE+ KE + P+
Sbjct: 649 FAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSES--DKEEADTPS 696
>gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 70.9 bits (172), Expect = 6e-12
Identities = 36/115 (31%), Positives = 63/115 (54%), Gaps = 7/115 (6%)
Query: 65 RGWLYKQDSTGMKL---WKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDH 121
+GWLYK+ G L WKK W +L L++Y ++ E G + LP F + +
Sbjct: 46 QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASE--- 102
Query: 122 INRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSEN 176
+K+AFK +HP ++T+YF + +EM +W+ L +A++ E + ++ SE+
Sbjct: 103 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLN-KLGSAVIHQESTTKDEECYSES 156
>gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 70.9 bits (172), Expect = 6e-12
Identities = 36/115 (31%), Positives = 63/115 (54%), Gaps = 7/115 (6%)
Query: 65 RGWLYKQDSTGMKL---WKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDH 121
+GWLYK+ G L WKK W +L L++Y ++ E G + LP F + +
Sbjct: 46 QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASE--- 102
Query: 122 INRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSEN 176
+K+AFK +HP ++T+YF + +EM +W+ L +A++ E + ++ SE+
Sbjct: 103 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLN-KLGSAVIHQESTTKDEECYSES 156
>gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [Homo
sapiens]
Length = 437
Score = 70.9 bits (172), Expect = 6e-12
Identities = 36/115 (31%), Positives = 63/115 (54%), Gaps = 7/115 (6%)
Query: 65 RGWLYKQDSTGMKL---WKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDH 121
+GWLYK+ G L WKK W +L L++Y ++ E G + LP F + +
Sbjct: 45 QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASE--- 101
Query: 122 INRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSEN 176
+K+AFK +HP ++T+YF + +EM +W+ L +A++ E + ++ SE+
Sbjct: 102 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLN-KLGSAVIHQESTTKDEECYSES 155
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 54.7 bits (130), Expect = 5e-07
Identities = 24/87 (27%), Positives = 44/87 (50%), Gaps = 1/87 (1%)
Query: 79 WKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTY 138
W+K W V ++ CLF+Y+ ++ L S+ L + + + + ++I + Y FK H Y
Sbjct: 949 WQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFK-LHFKSHVY 1007
Query: 139 YFCTDTGKEMELWMKAMLDAALVQTEP 165
YF ++ E WM+ + A + P
Sbjct: 1008 YFRAESEYTFERWMEVIRSATSSASRP 1034
>gi|50980301 myosin phosphatase-Rho interacting protein isoform 2
[Homo sapiens]
Length = 1025
Score = 54.7 bits (130), Expect = 5e-07
Identities = 67/281 (23%), Positives = 104/281 (37%), Gaps = 55/281 (19%)
Query: 25 DYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWF 84
D + P+SP ++ + +RS P+ ++GWL KQ G WKK WF
Sbjct: 358 DASASPLSP-------HRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQ--WKKHWF 408
Query: 85 VLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDT 144
VL+D L YYRD E + A L E ++ Y +P R Y F T
Sbjct: 409 VLADQSLRYYRDSVAE-----------EAADLDGEIDLSACYDV-TEYPVQRNYGFQIHT 456
Query: 145 GKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKE 204
KE E + AM ++ ++ + K T+++P +KNK
Sbjct: 457 -KEGEFTLSAMTSG--IRRNWIQTIMKHVHPTTAPDVTSSLP------------EEKNKS 501
Query: 205 MSKIE------EKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHY 258
E EK+ E G+ P K + + G + +
Sbjct: 502 SCSFETCPRPTEKQEAEL--------GEPDPEQKRSRAR-----ERRREGRSKTFDWAEF 548
Query: 259 RPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQR 299
RPI + ++ ++ V AD RP P E +R +R
Sbjct: 549 RPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRR 589
>gi|50980307 myosin phosphatase-Rho interacting protein isoform 1
[Homo sapiens]
Length = 1038
Score = 54.7 bits (130), Expect = 5e-07
Identities = 67/281 (23%), Positives = 104/281 (37%), Gaps = 55/281 (19%)
Query: 25 DYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWF 84
D + P+SP ++ + +RS P+ ++GWL KQ G WKK WF
Sbjct: 358 DASASPLSP-------HRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQ--WKKHWF 408
Query: 85 VLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDT 144
VL+D L YYRD E + A L E ++ Y +P R Y F T
Sbjct: 409 VLADQSLRYYRDSVAE-----------EAADLDGEIDLSACYDV-TEYPVQRNYGFQIHT 456
Query: 145 GKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKE 204
KE E + AM ++ ++ + K T+++P +KNK
Sbjct: 457 -KEGEFTLSAMTSG--IRRNWIQTIMKHVHPTTAPDVTSSLP------------EEKNKS 501
Query: 205 MSKIE------EKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHY 258
E EK+ E G+ P K + + G + +
Sbjct: 502 SCSFETCPRPTEKQEAEL--------GEPDPEQKRSRAR-----ERRREGRSKTFDWAEF 548
Query: 259 RPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQR 299
RPI + ++ ++ V AD RP P E +R +R
Sbjct: 549 RPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRR 589
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 54.7 bits (130), Expect = 5e-07
Identities = 44/140 (31%), Positives = 65/140 (46%), Gaps = 16/140 (11%)
Query: 31 MSP-VGRTSRASKKVHNFGKRSNSIKRNPN----APVVRRGWLYKQDSTGMKLWKKRWFV 85
+SP + + RA K G++S S R P PV++ GWL KQ S MK W++RWFV
Sbjct: 2 LSPKIRQARRARSKSLVMGEQSRSPGRMPCPHRLGPVLKAGWLKKQRSI-MKNWQQRWFV 60
Query: 86 LSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAA----------HPNM 135
L LFYY+D+ E G I L Q+ L K+ F+ + N
Sbjct: 61 LRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPGKHLFEISPGGAGEREKVPANP 120
Query: 136 RTYYFCTDTGKEMELWMKAM 155
+ ++ME W++A+
Sbjct: 121 EALLLMASSQRDMEDWVQAI 140
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 54.3 bits (129), Expect = 6e-07
Identities = 33/126 (26%), Positives = 65/126 (51%), Gaps = 9/126 (7%)
Query: 39 RASKKVHNFGKRSNSIKRNPNAPVVRR---GWLYKQ--DSTGMKLWKKRWFVLSDLCLFY 93
RA+ +H R+ S+ R ++ V G+L ++ +S G W+K W V ++ CLF+
Sbjct: 904 RANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHG---WQKLWVVFTNFCLFF 960
Query: 94 YRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMK 153
Y+ +++ L S+ L + +++ D I++ Y FK + Y+F ++ E WM+
Sbjct: 961 YKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKS-HVYFFRAESKYTFERWME 1019
Query: 154 AMLDAA 159
+ A+
Sbjct: 1020 VIQGAS 1025
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 53.5 bits (127), Expect = 1e-06
Identities = 31/101 (30%), Positives = 49/101 (48%), Gaps = 9/101 (8%)
Query: 63 VRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHI 122
++ GWL KQ +K W RWFVL L+Y++DE E LG+I LP +++ +
Sbjct: 21 IKCGWLRKQGGF-VKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEEN 79
Query: 123 NRKYAFKAA--------HPNMRTYYFCTDTGKEMELWMKAM 155
K+ F+ N +Y T +ME W+K++
Sbjct: 80 PGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSI 120
>gi|188497618 connector enhancer of kinase suppressor of Ras 1 [Homo
sapiens]
Length = 713
Score = 52.0 bits (123), Expect = 3e-06
Identities = 26/94 (27%), Positives = 49/94 (52%), Gaps = 6/94 (6%)
Query: 66 GWLYKQDSTGMKL---WKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHI 122
GWL + + G + W++RWFVL L++YR ++E G I + ++ L S
Sbjct: 401 GWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYS---LESGHDQ 457
Query: 123 NRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAML 156
+KY F+ H + + F DT ++ +W++ ++
Sbjct: 458 KKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLI 491
>gi|24432056 hypothetical protein LOC144717 [Homo sapiens]
Length = 249
Score = 51.6 bits (122), Expect = 4e-06
Identities = 33/111 (29%), Positives = 54/111 (48%), Gaps = 3/111 (2%)
Query: 49 KRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILL 108
+RS + +APV G+LYK+ + +RWFVL LFY+ D +G I+L
Sbjct: 5 ERSLAFYATCDAPVDNAGFLYKKGGRHAA-YHRRWFVLRGNMLFYFEDAASREPVGVIIL 63
Query: 109 PSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAA 159
+ L+ + + +A + A RTY ++ ME W+KA+ A+
Sbjct: 64 EGCTVELVEAAEEF--AFAVRFAGTRARTYVLAAESQDAMEGWVKALSRAS 112
>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
Length = 717
Score = 51.2 bits (121), Expect = 5e-06
Identities = 67/321 (20%), Positives = 128/321 (39%), Gaps = 57/321 (17%)
Query: 792 DYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESST 851
+ RL + + EL A++ E E ++ + I T + G + P + ES
Sbjct: 205 ELRLLEQKVEL---AQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQ- 260
Query: 852 IASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKK 911
+KM L R EQ+ E+ R +++E+ ++ R+++ +++
Sbjct: 261 ----------RKMNALFEGRRIEFAEQINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEG 310
Query: 912 GLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKEL-------------DTAIRENDVK 958
+ A + L+ N + N + ++KE+ + +E +VK
Sbjct: 311 KV----AQREEELEETGN-QHNDVEIEEAGEEEEKEIAIVHSDAEKEQEEEEQKQEMEVK 365
Query: 959 PDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEP--EPNGVNSVEMMDKERNK 1016
+ ET E + ++++P+ V L+ EN+ + + + E N V SVE + E +K
Sbjct: 366 MEEETEVRESEKQQDSQPEEV--MDVLEMVENVKHVIADQEVMETNRVESVEPSENEASK 423
Query: 1017 DKMPE-DVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAV 1075
+ PE + P E ++ + E + + +E+EE
Sbjct: 424 ELEPEMEFEIEPDKECKSLSPGKENVSALDMEKESEEKEE-------------------- 463
Query: 1076 KSLSPSPESSASPVPSTQPQL 1096
K P PE A P P +QPQL
Sbjct: 464 KESEPQPEPVAQPQPQSQPQL 484
>gi|55770898 Rho GTPase activating protein 25 isoform a [Homo
sapiens]
Length = 645
Score = 49.7 bits (117), Expect = 2e-05
Identities = 31/104 (29%), Positives = 49/104 (47%), Gaps = 8/104 (7%)
Query: 57 NPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALL 116
NP ++ GWL KQ S +K W++R+FVL L+YY+DE++ G + LP I +
Sbjct: 42 NPLERPIKMGWLKKQRSI-VKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEI 100
Query: 117 TSEDHINRKYAFKAA-------HPNMRTYYFCTDTGKEMELWMK 153
+ K+ F+ +Y + EME W+K
Sbjct: 101 ATNPEEAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVK 144
>gi|7661882 Rho GTPase activating protein 25 isoform b [Homo
sapiens]
Length = 638
Score = 49.7 bits (117), Expect = 2e-05
Identities = 31/104 (29%), Positives = 49/104 (47%), Gaps = 8/104 (7%)
Query: 57 NPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALL 116
NP ++ GWL KQ S +K W++R+FVL L+YY+DE++ G + LP I +
Sbjct: 35 NPLERPIKMGWLKKQRSI-VKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEI 93
Query: 117 TSEDHINRKYAFKAA-------HPNMRTYYFCTDTGKEMELWMK 153
+ K+ F+ +Y + EME W+K
Sbjct: 94 ATNPEEAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVK 137
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 49.3 bits (116), Expect = 2e-05
Identities = 65/290 (22%), Positives = 113/290 (38%), Gaps = 31/290 (10%)
Query: 800 PELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVV---PPRAKSPTPESSTIASYV 856
PE E +E+ EK++ + E + + PV P +AKSP E +
Sbjct: 649 PEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAK----- 703
Query: 857 TLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVI 916
+ K K + + P A + E+ P E + ++A EK K L+V
Sbjct: 704 SPEKAKSPVKEEAKSPEKAKSPV-KEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVK 762
Query: 917 GASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPDHETPATEIVQLKETEP 976
++P + + R DK + A ++ VK + ++P LKE
Sbjct: 763 SPEAKTPAKE------------EARSPADKFPEKA--KSPVKEEVKSPEKAKSPLKEDAK 808
Query: 977 QNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMPEDVTFSPQDETQTANH 1036
KE+ K E + + E +P V V+ K+ ++K P +P+ E + +
Sbjct: 809 AP---EKEIPKKEEVKSPVKEEEKPQEVK-VKEPPKKAEEEKAPA----TPKTEEKKDSK 860
Query: 1037 KPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSPSPESSA 1086
K E +E K V+E++E + +V + K P+PE A
Sbjct: 861 KEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEA 910
Score = 42.7 bits (99), Expect = 0.002
Identities = 64/338 (18%), Positives = 131/338 (38%), Gaps = 47/338 (13%)
Query: 800 PELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPV---GVVPPRAKSPTPESSTIASYV 856
PE +E+ EK++ + E + + PV P +AKSP E +
Sbjct: 691 PEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA 750
Query: 857 TLRKTKKMMDLRTERPRSAVEQLCLAESTR----PRMTVEEQMERIRRHQQACLREKKKG 912
+ K +D+++ ++ ++ + + + + V+E+++ + + + K
Sbjct: 751 KSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAP 810
Query: 913 LNVIGASDQSPLQSPSNLRDNP--FRTTQTRRRDDKELDTAIRENDVK--------PDHE 962
I ++ ++SP + P + + ++ ++E A + + K P E
Sbjct: 811 EKEIPKKEE--VKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKE 868
Query: 963 TPATEIVQLKETEPQNVDFSK-ELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKM-- 1019
P ++ + KE + SK E KK E + + PE VE+ + + K+K
Sbjct: 869 APKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEV 928
Query: 1020 ----PEDVTFSP--------------QDETQTANHKPEEHPEENTKNSVDEQEETVISYE 1061
P+D +D + KPEE P+ T+ E ++T+
Sbjct: 929 AKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPK--TEAKAKEDDKTLSKEP 986
Query: 1062 STPEVSRGNQTMAVKSLSPSPESSASPVPSTQPQLTEG 1099
S P+ + A KS S + S P +T+ + +G
Sbjct: 987 SKPKAEK-----AEKSSSTDQKDSKPPEKATEDKAAKG 1019
>gi|50234893 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 48.1 bits (113), Expect = 4e-05
Identities = 35/121 (28%), Positives = 62/121 (51%), Gaps = 6/121 (4%)
Query: 59 NAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSF-QIALLT 117
++ V++ G+ KQ + MK WK+R+F L + + Y++ E E+ L I L ++
Sbjct: 189 DSAVIKAGYCVKQGAV-MKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECK 247
Query: 118 SEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENA 177
D + R F+ + RT+Y D+ +EM W+KA+ A + Q P + +SE+
Sbjct: 248 QSDIMMRDNLFEIVTTS-RTFYVQADSPEEMHSWIKAVSGAIVAQRGPGR---SASSEHP 303
Query: 178 P 178
P
Sbjct: 304 P 304
>gi|31377720 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 48.1 bits (113), Expect = 4e-05
Identities = 35/121 (28%), Positives = 62/121 (51%), Gaps = 6/121 (4%)
Query: 59 NAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSF-QIALLT 117
++ V++ G+ KQ + MK WK+R+F L + + Y++ E E+ L I L ++
Sbjct: 189 DSAVIKAGYCVKQGAV-MKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECK 247
Query: 118 SEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENA 177
D + R F+ + RT+Y D+ +EM W+KA+ A + Q P + +SE+
Sbjct: 248 QSDIMMRDNLFEIVTTS-RTFYVQADSPEEMHSWIKAVSGAIVAQRGPGR---SASSEHP 303
Query: 178 P 178
P
Sbjct: 304 P 304
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 48.1 bits (113), Expect = 4e-05
Identities = 51/229 (22%), Positives = 94/229 (41%), Gaps = 24/229 (10%)
Query: 870 ERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNV-IGASDQSPLQSPS 928
+R R E E R R EE+ R+ ++A EK K L+ +G ++ P SP
Sbjct: 447 QRRRQQSEISAAVERARKRR--EEEERRMEEQRKAACAEKLKRLDEKLGILEKQP--SPE 502
Query: 929 NLRDNPFRTTQTRRRDDKELDTAIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKT 988
+R+ + R ++ ++ RE + + D E + +L++ + + + KE K+
Sbjct: 503 EIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQE 562
Query: 989 ENISYEMLFEPEPNGVNSVEMMDKERNKDKMPEDVTFSPQDETQTANHKPEEHPEENTKN 1048
+ E +KE+ KM E ++ + + E E N +
Sbjct: 563 KEKELE-------------RQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEP 609
Query: 1049 SVDEQE-ETVISYESTPEVSRGNQTMAVKSLSP-----SPESSASPVPS 1091
V++QE E + E P +R + + K +P PES + P P+
Sbjct: 610 MVEKQESENSCNKEEEPVFTRQDSNRSEKEATPVVHETEPESGSQPRPA 658
Score = 33.1 bits (74), Expect = 1.5
Identities = 39/164 (23%), Positives = 71/164 (43%), Gaps = 11/164 (6%)
Query: 575 EQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLS 634
+Q ++ A+E ++ +E+ +E+ +A E D I L++ +
Sbjct: 451 QQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGI----LEKQPSPEEIRE 506
Query: 635 TCRELSRATA-ELERAWREYDKLEYDVTVTRNQMQE-QLDHLGEVQTESAGIQRAQIQKE 692
RE R ELE+ + + E + R Q +E +L+ E Q E ++ + +KE
Sbjct: 507 REREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKE 566
Query: 693 LWRIQDVMEGLSKHKQQRGMIGSKPFSTVKYKNEEEEVVPPRPP 736
L R ++ + L K K+Q K K + + EE + PR P
Sbjct: 567 LERQKEKEKELQKMKEQ-----EKECELEKEREKLEEKIEPREP 605
>gi|217416392 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 2 [Homo sapiens]
Length = 1493
Score = 47.8 bits (112), Expect = 6e-05
Identities = 49/171 (28%), Positives = 73/171 (42%), Gaps = 31/171 (18%)
Query: 3 SEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPV 62
S +R +S+ + AS SDYA+ P + T + + S+S N P+
Sbjct: 649 SPRAMKRGVSLSSVASE----SDYAIPPDAYSTDTEYSQPEQKLPKTCSSSSDNGKNEPL 704
Query: 63 VRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRD-----EKEEGILG-----SILL-PSF 111
+ G+L K S +K WK+RWFVL L YY+ K +G + SIL +
Sbjct: 705 EKSGYLLKM-SGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNK 763
Query: 112 QIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQ 162
Q LT+E H TYY D+ +E W+K + + VQ
Sbjct: 764 QTVQLTTEKH---------------TYYLTADSPNILEEWIKVLQNVLRVQ 799
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 47.8 bits (112), Expect = 6e-05
Identities = 31/152 (20%), Positives = 74/152 (48%), Gaps = 10/152 (6%)
Query: 46 NFGKRSNSIKRNPNAP--VVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGIL 103
+F + ++ N +A +V G+L+K+ S K W +RWF + + L Y + K+
Sbjct: 249 DFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKFKDN--- 305
Query: 104 GSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKA----MLDAA 159
++++ ++ + + I R++ F+ P ++ D+ K + W+KA + A
Sbjct: 306 PTVVVEDLRLCTVKHCEDIERRFCFEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAY 364
Query: 160 LVQTEPVKRVDKITSENAPTKETNNIPNHRVL 191
+ + +++DK +S + + ++ N ++L
Sbjct: 365 REKGDESEKLDKKSSPSTGSLDSGNESKEKLL 396
>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
Length = 398
Score = 47.8 bits (112), Expect = 6e-05
Identities = 30/110 (27%), Positives = 50/110 (45%), Gaps = 18/110 (16%)
Query: 64 RRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYR---DEKEEGIL-----------GSILLP 109
R GWL K +K WK+RWF+L+D CL+Y+ D++ GI+ S
Sbjct: 263 REGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPN 322
Query: 110 SFQIALLTSEDHINRKYAFKA----AHPNMRTYYFCTDTGKEMELWMKAM 155
F++ + ++D + + +A N Y T +E E W+K +
Sbjct: 323 CFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCI 372
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 47.4 bits (111), Expect = 8e-05
Identities = 126/622 (20%), Positives = 237/622 (38%), Gaps = 84/622 (13%)
Query: 522 IENSALRPQ----LYQQFLRQKSKISLYCLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQD 577
IE L+ Q L Q+ ++ K+ E R L K EVD + K SR ++
Sbjct: 258 IEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKL---EVDFEHKASRFSQEH 314
Query: 578 KVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQN------- 630
+ ++A KL L L+ +Q IE + +Q + +L++
Sbjct: 315 EEMNA---KLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGEC 371
Query: 631 ---GLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRA 687
L++ L + E+E E K E R ++QE+ H E++ E
Sbjct: 372 GNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEV-----E 426
Query: 688 QIQKELWRIQDVMEGLSKHKQQRGMIG---SKPFSTVKYKNEEEEVVPPR-PPLPRSYDF 743
++QK + ++ + E SK K + + K + K E EVV R L S
Sbjct: 427 KLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESR 486
Query: 744 TEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKK--MYQVQGYPRNGSHCGPDYRLYKSEPE 801
E+ + L D + L ++ V L +E+K M +++ R ++++ + +
Sbjct: 487 LEKAEL--SLKDDLTKLKSFT---VMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVM 541
Query: 802 LTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKT 861
T ++ES K + SE+E V + ++ + KS +SS ++ V L K
Sbjct: 542 DVTEKLIEESKKLLKLK--SEMEEKVYNLTRERDELI-GKLKSEEEKSSELSCSVDLLKK 598
Query: 862 K------KMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNV 915
+ ++ R R E C ++ +T+E +ER+++ Q L V
Sbjct: 599 RLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLE--IERLKKRLQQ--------LEV 648
Query: 916 IGASDQSPLQSPSNLRDNPFRTTQTR----RRDDKELDTAIRENDVKPDHETPATEIV-- 969
+ D + + + FRT Q + + +E+ I +N E + E
Sbjct: 649 V-EGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELR 707
Query: 970 -QLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVE-------MMDKERNKDKMPE 1021
+ + E ++ D E++ + +E++ + + V+ M++E M +
Sbjct: 708 HRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQ 767
Query: 1022 DVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSPS 1081
+V ++ + + P N + VD P S G QT AV +
Sbjct: 768 EVLNLTKELELSKRYSRALRPSVNGRRMVD-----------VPVTSTGVQTDAVSGEAAE 816
Query: 1082 PESSASPVPSTQPQLTEGSHFM 1103
E +P + E +H M
Sbjct: 817 EE---TPAVFIRKSFQEENHIM 835
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 47.0 bits (110), Expect = 1e-04
Identities = 114/559 (20%), Positives = 223/559 (39%), Gaps = 91/559 (16%)
Query: 528 RPQLYQQFLRQKSKISLYCLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEE-- 585
+ Q QQ L+Q+ + L Q G + EE + +A++ E + +EE
Sbjct: 2061 KEQELQQTLQQEQSV----LDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAE 2115
Query: 586 KLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAE 645
+L+Q +E+ +A++++ A+ AA + Q + R+ A AE
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ---------AALRQKQAADAE 2166
Query: 646 LER-------AWREYDKLEYDVTVTRNQMQE----------QLDHLGEVQTESAGIQRAQ 688
+E+ R+ ++E ++T R Q++E +L L TE+A QR+Q
Sbjct: 2167 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR-QRSQ 2225
Query: 689 IQKELWRIQDVMEGLSKHK-----QQRGMIGSKPFSTVKYKNEE-EEVVPPRPPLPRSYD 742
+++EL+ ++ ME LSK K + R +I +T ++ EE E++ R
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285
Query: 743 FTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQGYPRNGSHCGPDYRLYKSEPEL 802
++ + L + L R ++KM VQ R K+E EL
Sbjct: 2286 AAQEAARLRQLAEED---LAQQRALAEKMLKEKMQAVQEATR-----------LKAEAEL 2331
Query: 803 TTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTK 862
+ + +E++ + E + + + A+ T+ + + +
Sbjct: 2332 ---LQQQKELAQEQARRLQEDKEQMAQ----------QLAEETQGFQRTLEA-----ERQ 2373
Query: 863 KMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVIGASDQS 922
+ +++ E R +L +AE +R + EE +R R+ + + EK + +
Sbjct: 2374 RQLEMSAEAERL---KLRVAEMSRAQARAEEDAQRFRKQAEE-IGEKLHRTELATQEKVT 2429
Query: 923 PLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPDHETPATEIVQLKETEPQNVDFS 982
+Q+ R Q D + L AI E + + + +++QLK E Q V
Sbjct: 2430 LVQTLEIQR-------QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2482
Query: 983 KELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMPEDVTFSPQDETQTANHKPEEHP 1042
+ L++T+ + L E + ++ +ER ++ + QDE A EE
Sbjct: 2483 QLLQETQALQQSFLSEKD-------SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ- 2534
Query: 1043 EENTKNSVDEQEETVISYE 1061
+ + E++ V S E
Sbjct: 2535 QRQQQQMEQERQRLVASME 2553
Score = 30.8 bits (68), Expect = 7.4
Identities = 43/170 (25%), Positives = 77/170 (45%), Gaps = 20/170 (11%)
Query: 560 RPEEVDIDAKLSRLCEQDKV--VHALEEKLQQLH------KEKYTLEQALLSASQEIEMH 611
R EE + A+ R E++++ V A EK +QL K + E L + E+
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 612 ADNPAAIQTVVLQR---DDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQ 668
AA+ +R ++LQ S+ E+ + E A R ++E ++ V R Q++
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 669 ----EQLDHLGEVQT-----ESAGIQRAQIQKELWRIQDVMEGLSKHKQQ 709
++ GE+Q E A Q+ Q Q+E R++ ++ S+ K+Q
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,889,401
Number of Sequences: 37866
Number of extensions: 2320630
Number of successful extensions: 10310
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 510
Number of HSP's that attempted gapping in prelim test: 9173
Number of HSP's gapped (non-prelim): 1663
length of query: 1105
length of database: 18,247,518
effective HSP length: 113
effective length of query: 992
effective length of database: 13,968,660
effective search space: 13856910720
effective search space used: 13856910720
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.