Search of human proteins with 217035081

Search of human proteins with 217035081

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|217035081 aarF domain containing kinase 1 isoform b [Homo
sapiens]
         (455 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|217035081 aarF domain containing kinase 1 isoform b [Homo sap...   915   0.0  
gi|40254938 aarF domain containing kinase 1 isoform a [Homo sapi...   779   0.0  
gi|41393593 aarF domain containing kinase 5 [Homo sapiens]            244   2e-64
gi|34147522 chaperone, ABC1 activity of bc1 complex like precurs...    75   1e-13
gi|217416386 aarF domain containing kinase 4 isoform b [Homo sap...    71   2e-12
gi|27363457 aarF domain containing kinase 4 isoform a [Homo sapi...    71   2e-12
gi|32261307 aarF domain containing kinase 2 [Homo sapiens]             65   2e-10
gi|145312265 endoplasmic reticulum to nucleus signalling 2 [Homo...    39   0.013
gi|109255245 serine/threonine kinase 17a [Homo sapiens]                36   0.063
gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]       35   0.14 
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]        35   0.14 
gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]       35   0.14 
gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]        35   0.14 
gi|4758128 doublecortin-like kinase 1 [Homo sapiens]                   34   0.24 
gi|167466233 myosin light chain kinase family, member 4 [Homo sa...    33   0.70 
gi|48314820 5-oxoprolinase (ATP-hydrolysing) [Homo sapiens]            32   1.2  
gi|146219832 myosin light chain kinase 3 [Homo sapiens]                32   1.2  
gi|50727002 pseudouridylate synthase 7 homolog [Homo sapiens]          31   2.7  
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun...    30   3.5  
gi|20128768 serine/threonine kinase 35 [Homo sapiens]                  30   3.5  
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...    30   3.5  
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...    30   3.5  
gi|4502141 baculoviral IAP repeat-containing protein 2 [Homo sap...    30   4.5  
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]       30   4.5  
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]       30   4.5  
gi|9966821 ectonucleoside triphosphate diphosphohydrolase 7 [Hom...    30   4.5  
gi|38683840 CD96 antigen isoform 1 precursor [Homo sapiens]            30   5.9  
gi|5032141 CD96 antigen isoform 2 precursor [Homo sapiens]             30   5.9  
gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens]      30   5.9  
gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens]            30   5.9  

>gi|217035081 aarF domain containing kinase 1 isoform b [Homo
           sapiens]
          Length = 455

 Score =  915 bits (2366), Expect = 0.0
 Identities = 455/455 (100%), Positives = 455/455 (100%)

Query: 1   MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSV 60
           MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSV
Sbjct: 1   MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSV 60

Query: 61  PYGSEEYLQLRSKIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSK 120
           PYGSEEYLQLRSKIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSK
Sbjct: 61  PYGSEEYLQLRSKIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSK 120

Query: 121 DILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFLKV 180
           DILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFLKV
Sbjct: 121 DILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFLKV 180

Query: 181 PRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCD 240
           PRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCD
Sbjct: 181 PRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCD 240

Query: 241 PHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRL 300
           PHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRL
Sbjct: 241 PHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRL 300

Query: 301 GAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHLLNHVPRQM 360
           GAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHLLNHVPRQM
Sbjct: 301 GAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHLLNHVPRQM 360

Query: 361 LLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRTQISFSEAF 420
           LLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRTQISFSEAF
Sbjct: 361 LLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRTQISFSEAF 420

Query: 421 NLWQINLHELILRVKGLKLADRVLALICWLFPAPL 455
           NLWQINLHELILRVKGLKLADRVLALICWLFPAPL
Sbjct: 421 NLWQINLHELILRVKGLKLADRVLALICWLFPAPL 455


>gi|40254938 aarF domain containing kinase 1 isoform a [Homo
           sapiens]
          Length = 523

 Score =  779 bits (2012), Expect = 0.0
 Identities = 412/523 (78%), Positives = 429/523 (82%), Gaps = 68/523 (13%)

Query: 1   MARKALKLASWTSM---------------------------ALAASGIYFY--------- 24
           MARKALKLASWTSM                           A+A + +  Y         
Sbjct: 1   MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSV 60

Query: 25  ---SNKYLD------------------PNDFGAVRVGRAV-ATTAVISYDYLTSLK---- 58
              S +YL                    N    ++VG+ + A   ++  +Y ++LK    
Sbjct: 61  PYGSEEYLQLRSKVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTSTLKVLHS 120

Query: 59  SVPYGSEEYLQ------LRSKIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHP 112
             P  S + ++      L  +IHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHP
Sbjct: 121 QAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHP 180

Query: 113 KVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQML 172
           KVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQML
Sbjct: 181 KVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQML 240

Query: 173 RHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIF 232
           RHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIF
Sbjct: 241 RHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIF 300

Query: 233 VNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKR 292
           VNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKR
Sbjct: 301 VNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKR 360

Query: 293 VKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHL 352
           VKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHL
Sbjct: 361 VKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHL 420

Query: 353 LNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRT 412
           LNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRT
Sbjct: 421 LNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRT 480

Query: 413 QISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL 455
           QISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL
Sbjct: 481 QISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL 523


>gi|41393593 aarF domain containing kinase 5 [Homo sapiens]
          Length = 580

 Score =  244 bits (622), Expect = 2e-64
 Identities = 152/384 (39%), Positives = 221/384 (57%), Gaps = 31/384 (8%)

Query: 75  HDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSKDILLMEVLVLAVKQ 134
           H+LFQ FD  P+  ASLAQVH+A LHDG +VAVKVQ+  +R +   DI  +E+L+  V+ 
Sbjct: 195 HELFQEFDYQPIAAASLAQVHRAKLHDGTSVAVKVQYIDLRDRFDGDIHTLELLLRLVEV 254

Query: 135 LFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLL 194
           + P F F W++ + K  L  ELDF NEGRNAE+ ++ L HF ++ VPR+HWD S++RVL 
Sbjct: 255 MHPSFGFSWVLQDLKGTLAQELDFENEGRNAERCARELAHFPYVVVPRVHWDKSSKRVLT 314

Query: 195 MEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGT 254
            +F  G +VND + +    + V++I+  L K ++E IF  GF+H DPHPGNVLVRK P  
Sbjct: 315 ADFCAGCKVNDVEAIRSQGLAVHDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGP-D 373

Query: 255 GKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLGAGDLYPLFACMLT 314
           GKAE+VLLDHGLYQ L E+ R   C LW+++I  D   ++ ++  LG  D Y LFA ML 
Sbjct: 374 GKAELVLLDHGLYQFLEEKDRAALCQLWRAIILRDDAAMRAHAAALGVQD-YLLFAEMLM 432

Query: 315 ARS------WDSVNRGISQAPVTATEDLEIRNNAANYLPQISHLLNHVPRQMLLILKTND 368
            R       W S    +S+       D+     A      +  +L  +PR MLL+L+  +
Sbjct: 433 QRPVRLGQLWGS--HLLSREEAAYMVDM-----ARERFEAVMAVLRELPRPMLLVLRNIN 485

Query: 369 LLRGIEAALGTRASASSFLNMSRCCIR-----ALAEHKKKNTCSFFRRTQISFSEAFNLW 423
            +R I  ALG  A    +  M++  +R     A A ++     S  R  ++       +W
Sbjct: 486 TVRAINVALG--APVDRYFLMAKRAVRGWSRLAGATYRGVYGTSLLRHAKV-------VW 536

Query: 424 QINLHELILRVKGLKLADRVLALI 447
           ++   E+ LR++   LA R+ AL+
Sbjct: 537 EMLKFEVALRLE--TLAMRLTALL 558


>gi|34147522 chaperone, ABC1 activity of bc1 complex like precursor
           [Homo sapiens]
          Length = 647

 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 64/224 (28%), Positives = 105/224 (46%), Gaps = 18/224 (8%)

Query: 76  DLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSKDI-LLMEVLVLA--- 131
           D  + F++ P   AS+ QVH A +  GR VA+K+Q+P V    + D+  LM VL ++   
Sbjct: 326 DKLEYFEERPFAAASIGQVHLARMKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNML 385

Query: 132 VKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTER 191
            + LFPE     L+D  ++ L LE D+  E   A K   +L+   F  VP I  +L +  
Sbjct: 386 PEGLFPEH----LIDVLRRELALECDYQREAACARKFRDLLKGHPFFYVPEIVDELCSPH 441

Query: 192 VLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKH 251
           VL  E V G  ++  + + +     NEI  ++  +    +F   F+  DP+  N      
Sbjct: 442 VLTTELVSGFPLDQAEGLSQE--IRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQ 499

Query: 252 PGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKE 295
               + ++ LLD G     T E+  ++  L+  +I     R +E
Sbjct: 500 ----QHKVALLDFG----ATREYDRSFTDLYIQIIRAAADRDRE 535


>gi|217416386 aarF domain containing kinase 4 isoform b [Homo
           sapiens]
          Length = 503

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 63/225 (28%), Positives = 101/225 (44%), Gaps = 14/225 (6%)

Query: 80  SFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSKDIL-LMEVLVLAV---KQL 135
           S ++ P   AS+ QVH+ +L DG  VAVK+Q+P +      D+  L+ VL ++      L
Sbjct: 168 SLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAVLKMSAALPAGL 227

Query: 136 FPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLM 195
           F E     L  E    L  E D+  E   A+   Q+L +  F +VP +  +L T RVL M
Sbjct: 228 FAEQSLQALQQE----LAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGM 283

Query: 196 EFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTG 255
           E   G  ++    + ++    N+I   L  +    +F   F+  DP+  N L        
Sbjct: 284 ELAGGVPLDQCQGLSQDL--RNQICFQLLTLCLRELFEFRFMQTDPNWANFLY----DAS 337

Query: 256 KAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRL 300
             ++ LLD G  +    EF  +Y  + ++    D   V + S+ L
Sbjct: 338 SHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRDCVLQKSRDL 382


>gi|27363457 aarF domain containing kinase 4 isoform a [Homo
           sapiens]
          Length = 544

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 63/225 (28%), Positives = 101/225 (44%), Gaps = 14/225 (6%)

Query: 80  SFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSKDIL-LMEVLVLAV---KQL 135
           S ++ P   AS+ QVH+ +L DG  VAVK+Q+P +      D+  L+ VL ++      L
Sbjct: 209 SLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAVLKMSAALPAGL 268

Query: 136 FPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLM 195
           F E     L  E    L  E D+  E   A+   Q+L +  F +VP +  +L T RVL M
Sbjct: 269 FAEQSLQALQQE----LAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGM 324

Query: 196 EFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTG 255
           E   G  ++    + ++    N+I   L  +    +F   F+  DP+  N L        
Sbjct: 325 ELAGGVPLDQCQGLSQDL--RNQICFQLLTLCLRELFEFRFMQTDPNWANFLY----DAS 378

Query: 256 KAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRL 300
             ++ LLD G  +    EF  +Y  + ++    D   V + S+ L
Sbjct: 379 SHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRDCVLQKSRDL 423


>gi|32261307 aarF domain containing kinase 2 [Homo sapiens]
          Length = 626

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 50/159 (31%), Positives = 77/159 (48%), Gaps = 6/159 (3%)

Query: 104 TVAVKVQHPKVRAQSSKDILLMEV--LVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNE 161
           +VAVKV HP + AQ   D+LLM++   VL V           +V+E +K +  ++D   E
Sbjct: 307 SVAVKVLHPGLLAQVHMDLLLMKIGSRVLGVLPGIKWLSLPEIVEEFEKLMVQQIDLRYE 366

Query: 162 GRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERN-KIDVNEIS 220
            +N E      R+   +K P       T  VL+  + +   V+   Y +    +D+    
Sbjct: 367 AQNLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVPVSS--YQQAGIPVDLKRKI 424

Query: 221 RHLG-KMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAE 258
             LG  M  +MIFV+ FVH D HPGN+LV+   G   ++
Sbjct: 425 ARLGINMLLKMIFVDNFVHADLHPGNILVQGANGLSSSQ 463


>gi|145312265 endoplasmic reticulum to nucleus signalling 2 [Homo
           sapiens]
          Length = 974

 Score = 38.5 bits (88), Expect = 0.013
 Identities = 58/241 (24%), Positives = 98/241 (40%), Gaps = 36/241 (14%)

Query: 56  SLKSVPYGSEEYLQLRSKIHDLFQSFDDTPLGTASLAQVHKAV--LHDG--RTVAVKVQH 111
           SL +V  G      +R +   + +   +TPL  A  A + +    LH G  R    ++Q 
Sbjct: 485 SLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQS 544

Query: 112 PKVRAQSSKDILLMEVLVLAVKQLFPE----------FEFMW-----------LVDEAKK 150
           P  +AQ   D    ++ V+      P+          F F             L+ E   
Sbjct: 545 PSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFG 604

Query: 151 NLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHW-DLSTERVLLMEFVDGGQVNDRDYM 209
            +  E+  L E   +++   +LR+F   + P+ H+  L   R  L E+V+   + DR  +
Sbjct: 605 LVRREVQLLQE---SDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDL-DRGGL 660

Query: 210 ERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQM 269
           E   + + ++   L  ++S  I     VH D  PGN+L+      G   +VL D GL + 
Sbjct: 661 EPEVV-LQQLMSGLAHLHSLHI-----VHRDLKPGNILITGPDSQGLGRVVLSDFGLCKK 714

Query: 270 L 270
           L
Sbjct: 715 L 715


>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
          Length = 414

 Score = 36.2 bits (82), Expect = 0.063
 Identities = 43/197 (21%), Positives = 80/197 (40%), Gaps = 49/197 (24%)

Query: 86  LGTASLAQVHKAVLHD-GRTVAVKVQHPKVRAQSSKDILLMEVLVLAVKQLFPEFEFMWL 144
           LG    A V K +  D G+  A K    + + Q  +  ++ E+ VL + Q  P     W+
Sbjct: 67  LGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNP-----WV 121

Query: 145 VDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVN 204
           +                  N  +V                ++ ++E +L++E+  GG++ 
Sbjct: 122 I------------------NLHEV----------------YETASEMILVLEYAAGGEIF 147

Query: 205 DRDYMERNKI----DVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAEIV 260
           D+   +R +     DV  + R + +     +     VH D  P N+L+      G  +I 
Sbjct: 148 DQCVADREEAFKEKDVQRLMRQILEGV-HFLHTRDVVHLDLKPQNILLTSESPLG--DIK 204

Query: 261 LLDHGLYQML--TEEFR 275
           ++D GL ++L  +EE R
Sbjct: 205 IVDFGLSRILKNSEELR 221


>gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]
          Length = 1863

 Score = 35.0 bits (79), Expect = 0.14
 Identities = 24/81 (29%), Positives = 41/81 (50%), Gaps = 5/81 (6%)

Query: 192  VLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYS--EMIFVNGFVHCDPHPGNVLVR 249
            V+++E V GG++ +R   E  ++   E  +++ ++    E I   G VH D  P N++  
Sbjct: 1535 VMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCV 1594

Query: 250  KHPGTGKAEIVLLDHGLYQML 270
               GT    I L+D GL + L
Sbjct: 1595 NKTGT---RIKLIDFGLARRL 1612


>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
          Length = 1914

 Score = 35.0 bits (79), Expect = 0.14
 Identities = 24/81 (29%), Positives = 41/81 (50%), Gaps = 5/81 (6%)

Query: 192  VLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYS--EMIFVNGFVHCDPHPGNVLVR 249
            V+++E V GG++ +R   E  ++   E  +++ ++    E I   G VH D  P N++  
Sbjct: 1535 VMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCV 1594

Query: 250  KHPGTGKAEIVLLDHGLYQML 270
               GT    I L+D GL + L
Sbjct: 1595 NKTGT---RIKLIDFGLARRL 1612


>gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]
          Length = 1794

 Score = 35.0 bits (79), Expect = 0.14
 Identities = 24/81 (29%), Positives = 41/81 (50%), Gaps = 5/81 (6%)

Query: 192  VLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYS--EMIFVNGFVHCDPHPGNVLVR 249
            V+++E V GG++ +R   E  ++   E  +++ ++    E I   G VH D  P N++  
Sbjct: 1466 VMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCV 1525

Query: 250  KHPGTGKAEIVLLDHGLYQML 270
               GT    I L+D GL + L
Sbjct: 1526 NKTGT---RIKLIDFGLARRL 1543


>gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]
          Length = 1845

 Score = 35.0 bits (79), Expect = 0.14
 Identities = 24/81 (29%), Positives = 41/81 (50%), Gaps = 5/81 (6%)

Query: 192  VLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYS--EMIFVNGFVHCDPHPGNVLVR 249
            V+++E V GG++ +R   E  ++   E  +++ ++    E I   G VH D  P N++  
Sbjct: 1466 VMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCV 1525

Query: 250  KHPGTGKAEIVLLDHGLYQML 270
               GT    I L+D GL + L
Sbjct: 1526 NKTGT---RIKLIDFGLARRL 1543


>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
          Length = 729

 Score = 34.3 bits (77), Expect = 0.24
 Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 4/83 (4%)

Query: 186 DLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVN--GFVHCDPHP 243
           D+ TE  L+ME V GG + D      NK    + S  L  + S + +++    VH D  P
Sbjct: 456 DVPTELYLVMELVKGGDLFDA-ITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKP 514

Query: 244 GNVLVRKHPGTGKAEIVLLDHGL 266
            N+LV +H   G   + L D GL
Sbjct: 515 ENLLVYEHQ-DGSKSLKLGDFGL 536


>gi|167466233 myosin light chain kinase family, member 4 [Homo
           sapiens]
          Length = 388

 Score = 32.7 bits (73), Expect = 0.70
 Identities = 32/130 (24%), Positives = 58/130 (44%), Gaps = 24/130 (18%)

Query: 161 EGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKI------ 214
           E +N   V   L H + +++    ++   + VL+ME+VDGG++ DR   E   +      
Sbjct: 147 EVKNEISVMNQLDHANLIQLYDA-FESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTI 205

Query: 215 ----DVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQML 270
                + E  RH+ +MY         +H D  P N+L          +I ++D GL +  
Sbjct: 206 LFMKQICEGIRHMHQMY--------ILHLDLKPENILCVNRDA---KQIKIIDFGLARRY 254

Query: 271 --TEEFRLNY 278
              E+ ++N+
Sbjct: 255 KPREKLKVNF 264


>gi|48314820 5-oxoprolinase (ATP-hydrolysing) [Homo sapiens]
          Length = 1288

 Score = 32.0 bits (71), Expect = 1.2
 Identities = 19/61 (31%), Positives = 28/61 (45%), Gaps = 10/61 (16%)

Query: 199 DGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAE 258
           DGG V++  +          I  HLG M   + F    +  D HPG+VL+  HP  G + 
Sbjct: 779 DGGLVSNAPH----------IPVHLGAMQETVQFQIQHLGADLHPGDVLLSNHPSAGGSH 828

Query: 259 I 259
           +
Sbjct: 829 L 829


>gi|146219832 myosin light chain kinase 3 [Homo sapiens]
          Length = 819

 Score = 32.0 bits (71), Expect = 1.2
 Identities = 27/93 (29%), Positives = 48/93 (51%), Gaps = 13/93 (13%)

Query: 193 LLMEFVDGGQVNDRDYMER---NKIDVNEISRHL--GKMYSEMIFVNGFVHCDPHPGNVL 247
           L+ME+VDGG++ DR   E+    ++DV   +R +  G  Y    ++   +H D  P N+L
Sbjct: 587 LVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYI---LHLDLKPENIL 643

Query: 248 VRKHPGTGKAEIVLLDHGLYQML--TEEFRLNY 278
                G    +I ++D GL +     E+ ++N+
Sbjct: 644 CVNQTG---HQIKIIDFGLARRYKPREKLKVNF 673


>gi|50727002 pseudouridylate synthase 7 homolog [Homo sapiens]
          Length = 661

 Score = 30.8 bits (68), Expect = 2.7
 Identities = 14/33 (42%), Positives = 21/33 (63%), Gaps = 2/33 (6%)

Query: 275 RLNYCHLWQSLIWTDM--KRVKEYSQRLGAGDL 305
           RL Y H +QS +W +M  KR+++Y  +   GDL
Sbjct: 472 RLMYIHSYQSYVWNNMVSKRIEDYGLKPVPGDL 504


>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
           [Homo sapiens]
          Length = 552

 Score = 30.4 bits (67), Expect = 3.5
 Identities = 30/127 (23%), Positives = 60/127 (47%), Gaps = 10/127 (7%)

Query: 156 LDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKID 215
           LD + + +   +  ++ RH   +K+ ++     T+  ++ME+V GG++ D    +  +++
Sbjct: 55  LDVVGKIKREIQNLKLFRHPHIIKLYQVI-STPTDFFMVMEYVSGGELFDY-ICKHGRVE 112

Query: 216 VNEISRHLGKMYSEMIFVNG--FVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTE- 272
             E  R   ++ S + + +    VH D  P NVL+  H         + D GL  M+++ 
Sbjct: 113 EMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAH-----MNAKIADFGLSNMMSDG 167

Query: 273 EFRLNYC 279
           EF    C
Sbjct: 168 EFLRTSC 174


>gi|20128768 serine/threonine kinase 35 [Homo sapiens]
          Length = 401

 Score = 30.4 bits (67), Expect = 3.5
 Identities = 44/186 (23%), Positives = 75/186 (40%), Gaps = 36/186 (19%)

Query: 86  LGTASLAQVHKAVL-HDGRTVAVKVQHPKVRAQSSKDILLMEVLVLAVKQLFPEFEFMWL 144
           +G  S   V++AV    G  VAVK    K+R  + +++ L             EF   W 
Sbjct: 75  IGRGSYGVVYEAVAGRSGARVAVK----KIRCDAPENVELA----------LAEF---WA 117

Query: 145 VDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDF---LKVPRIHWDLSTERVL-------- 193
           +   K+     + F         ++Q + H +    L +  +   L  ER+L        
Sbjct: 118 LTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCY 177

Query: 194 ---LMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFV--NGFVHCDPHPGNVLV 248
              +MEF +GG +N   Y+   + D       + ++ S + F+  N  VH D  P N+L+
Sbjct: 178 LWFVMEFCEGGDLNQ--YVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILI 235

Query: 249 RKHPGT 254
            +  GT
Sbjct: 236 TERSGT 241


>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform b [Homo sapiens]
          Length = 741

 Score = 30.4 bits (67), Expect = 3.5
 Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 12/84 (14%)

Query: 193 LLMEFVDGGQVNDRD-----YMERNKIDVN-EISRHLGKMYSEMIFVNGFVHCDPHPGNV 246
           L+ME + GG++ DR      + ER   DV   I++ +  ++S+     G VH D  P N+
Sbjct: 492 LVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQ-----GVVHRDLKPSNI 546

Query: 247 LVRKHPGTGKAEIVLLDHGLYQML 270
           L R   G+ ++ I + D G  + L
Sbjct: 547 LYRDESGSPES-IRVCDFGFAKQL 569


>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform a [Homo sapiens]
          Length = 733

 Score = 30.4 bits (67), Expect = 3.5
 Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 12/84 (14%)

Query: 193 LLMEFVDGGQVNDRD-----YMERNKIDVN-EISRHLGKMYSEMIFVNGFVHCDPHPGNV 246
           L+ME + GG++ DR      + ER   DV   I++ +  ++S+     G VH D  P N+
Sbjct: 484 LVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQ-----GVVHRDLKPSNI 538

Query: 247 LVRKHPGTGKAEIVLLDHGLYQML 270
           L R   G+ ++ I + D G  + L
Sbjct: 539 LYRDESGSPES-IRVCDFGFAKQL 561


>gi|4502141 baculoviral IAP repeat-containing protein 2 [Homo
           sapiens]
          Length = 618

 Score = 30.0 bits (66), Expect = 4.5
 Identities = 16/61 (26%), Positives = 26/61 (42%)

Query: 267 YQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLGAGDLYPLFACMLTARSWDSVNRGIS 326
           Y M TEE R    H+W     +  +  +     +G GD    FAC     +W+  +  +S
Sbjct: 179 YAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMS 238

Query: 327 Q 327
           +
Sbjct: 239 E 239


>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
          Length = 765

 Score = 30.0 bits (66), Expect = 4.5
 Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 4/83 (4%)

Query: 186 DLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNG--FVHCDPHP 243
           + +TE  L+ME V GG + D       K    + S  +  + + + +++G   VH D  P
Sbjct: 459 ETATELFLVMELVKGGDLFDA-ITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKP 517

Query: 244 GNVLVRKHPGTGKAEIVLLDHGL 266
            N+LV ++P  G   + L D GL
Sbjct: 518 ENLLVCEYP-DGTKSLKLGDFGL 539


>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
          Length = 766

 Score = 30.0 bits (66), Expect = 4.5
 Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 4/83 (4%)

Query: 186 DLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNG--FVHCDPHP 243
           + +TE  L+ME V GG + D       K    + S  +  + + + +++G   VH D  P
Sbjct: 460 ETATELFLVMELVKGGDLFDA-ITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKP 518

Query: 244 GNVLVRKHPGTGKAEIVLLDHGL 266
            N+LV ++P  G   + L D GL
Sbjct: 519 ENLLVCEYP-DGTKSLKLGDFGL 540


>gi|9966821 ectonucleoside triphosphate diphosphohydrolase 7 [Homo
           sapiens]
          Length = 604

 Score = 30.0 bits (66), Expect = 4.5
 Identities = 16/43 (37%), Positives = 25/43 (58%)

Query: 127 VLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVS 169
           +L  A  +L PE + + ++ +  K+LPLE DFL     AE +S
Sbjct: 171 ILCTAGMRLLPERKQLAILADLVKDLPLEFDFLFSQSQAEVIS 213


>gi|38683840 CD96 antigen isoform 1 precursor [Homo sapiens]
          Length = 585

 Score = 29.6 bits (65), Expect = 5.9
 Identities = 18/70 (25%), Positives = 30/70 (42%), Gaps = 2/70 (2%)

Query: 79  QSFDDTPLGTASLAQVHKAVLHDGRTVAV--KVQHPKVRAQSSKDILLMEVLVLAVKQLF 136
           Q FDD    +  +      +L    TV V  K + P +   +S D+L+       +K +F
Sbjct: 237 QIFDDGRKFSCHIRVGPNKILRSSTTVKVFAKPEIPVIVENNSTDVLVERRFTCLLKNVF 296

Query: 137 PEFEFMWLVD 146
           P+    W +D
Sbjct: 297 PKANITWFID 306


>gi|5032141 CD96 antigen isoform 2 precursor [Homo sapiens]
          Length = 569

 Score = 29.6 bits (65), Expect = 5.9
 Identities = 18/70 (25%), Positives = 30/70 (42%), Gaps = 2/70 (2%)

Query: 79  QSFDDTPLGTASLAQVHKAVLHDGRTVAV--KVQHPKVRAQSSKDILLMEVLVLAVKQLF 136
           Q FDD    +  +      +L    TV V  K + P +   +S D+L+       +K +F
Sbjct: 221 QIFDDGRKFSCHIRVGPNKILRSSTTVKVFAKPEIPVIVENNSTDVLVERRFTCLLKNVF 280

Query: 137 PEFEFMWLVD 146
           P+    W +D
Sbjct: 281 PKANITWFID 290


>gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens]
          Length = 1007

 Score = 29.6 bits (65), Expect = 5.9
 Identities = 26/85 (30%), Positives = 37/85 (43%), Gaps = 12/85 (14%)

Query: 260 VLLDHGLYQMLTEEFRLNY----------CHLWQSLIWT-DMKRVKEYSQRLGAGDLYPL 308
           V L  GLY+  +E+  L +             W+S   + D+      S RLGA    PL
Sbjct: 497 VHLGPGLYRYTSEDAILKHRMDHSDSQWLADTWRSTSGSRDLSSSSSLSSRLGADARDPL 556

Query: 309 FACMLTARSWDSVNRGISQAPVTAT 333
             C  +  SWDS + G+   P T+T
Sbjct: 557 -DCRRSLLSWDSRSPGVPLLPDTST 580


>gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens]
          Length = 718

 Score = 29.6 bits (65), Expect = 5.9
 Identities = 32/146 (21%), Positives = 71/146 (48%), Gaps = 28/146 (19%)

Query: 149 KKNLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVL--------------- 193
           ++ + +++  LN+    EK     +H    +  RIH +L   R++               
Sbjct: 431 QRYVAVKIHQLNKNWRDEKKENYHKHA--CREYRIHKELDHPRIVKLYDYFSLDTDSFCT 488

Query: 194 LMEFVDGGQVNDRD-YMERNKIDVNEISRHL-GKMYSEMIFVNGF----VHCDPHPGNVL 247
           ++E+ +G   ND D Y++++K+   + +R +  ++ + + ++N      +H D  PGN+L
Sbjct: 489 VLEYCEG---NDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNIL 545

Query: 248 VRKHPGTGKAEIVLLDHGLYQMLTEE 273
           +    GT   EI + D GL +++ ++
Sbjct: 546 LVN--GTACGEIKITDFGLSKIMDDD 569


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,675,722
Number of Sequences: 37866
Number of extensions: 633998
Number of successful extensions: 1858
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 1837
Number of HSP's gapped (non-prelim): 38
length of query: 455
length of database: 18,247,518
effective HSP length: 106
effective length of query: 349
effective length of database: 14,233,722
effective search space: 4967568978
effective search space used: 4967568978
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.