Guide to the Human Genome
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Search of human proteins with 215422413

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|215422413 fumarylacetoacetate hydrolase domain containing 1
isoform 3 [Homo sapiens]
         (226 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|215422413 fumarylacetoacetate hydrolase domain containing 1 i...   461   e-130
gi|13654274 fumarylacetoacetate hydrolase domain containing 1 is...   435   e-122
gi|66348062 fumarylacetoacetate hydrolase domain containing 1 is...   435   e-122
gi|156231349 fumarylacetoacetate hydrolase domain containing 2A ...   145   2e-35
gi|40786394 fumarylacetoacetate hydrolase domain containing 2B [...   144   8e-35
gi|4885503 myosin IA [Homo sapiens]                                    30   2.2  
gi|110349719 titin isoform N2-A [Homo sapiens]                         28   8.3  
gi|213972636 tumor protein p53 binding protein 1 isoform 1 [Homo...    28   8.3  
gi|213972634 tumor protein p53 binding protein 1 isoform 2 [Homo...    28   8.3  
gi|5032189 tumor protein p53 binding protein 1 isoform 3 [Homo s...    28   8.3  
gi|219555700 leucine rich repeat containing 27 isoform a [Homo s...    28   8.3  
gi|55741567 leucine rich repeat containing 27 isoform a [Homo sa...    28   8.3  

>gi|215422413 fumarylacetoacetate hydrolase domain containing 1
           isoform 3 [Homo sapiens]
          Length = 226

 Score =  461 bits (1185), Expect = e-130
 Identities = 226/226 (100%), Positives = 226/226 (100%)

Query: 1   MGIMAASRPLSRFWEWGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSPIL 60
           MGIMAASRPLSRFWEWGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSPIL
Sbjct: 1   MGIMAASRPLSRFWEWGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSPIL 60

Query: 61  MPAYTRNLHHELELGVVMGKRCRAVPEAAAMDYVGGYALCLDMTARDVQDECKKKGLPWT 120
           MPAYTRNLHHELELGVVMGKRCRAVPEAAAMDYVGGYALCLDMTARDVQDECKKKGLPWT
Sbjct: 61  MPAYTRNLHHELELGVVMGKRCRAVPEAAAMDYVGGYALCLDMTARDVQDECKKKGLPWT 120

Query: 121 LAKSFTASCPVSAFVPKEKIPDPHKLKLWLKVNGELRQEGETSSMIFSIPYIISYVSKII 180
           LAKSFTASCPVSAFVPKEKIPDPHKLKLWLKVNGELRQEGETSSMIFSIPYIISYVSKII
Sbjct: 121 LAKSFTASCPVSAFVPKEKIPDPHKLKLWLKVNGELRQEGETSSMIFSIPYIISYVSKII 180

Query: 181 TLEEGDIILTGTPKGVGPVKENDEIEAGIHGLPKVSSATLPVRLQE 226
           TLEEGDIILTGTPKGVGPVKENDEIEAGIHGLPKVSSATLPVRLQE
Sbjct: 181 TLEEGDIILTGTPKGVGPVKENDEIEAGIHGLPKVSSATLPVRLQE 226


>gi|13654274 fumarylacetoacetate hydrolase domain containing 1
           isoform 2 [Homo sapiens]
          Length = 224

 Score =  435 bits (1118), Expect = e-122
 Identities = 212/212 (100%), Positives = 212/212 (100%)

Query: 1   MGIMAASRPLSRFWEWGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSPIL 60
           MGIMAASRPLSRFWEWGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSPIL
Sbjct: 1   MGIMAASRPLSRFWEWGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSPIL 60

Query: 61  MPAYTRNLHHELELGVVMGKRCRAVPEAAAMDYVGGYALCLDMTARDVQDECKKKGLPWT 120
           MPAYTRNLHHELELGVVMGKRCRAVPEAAAMDYVGGYALCLDMTARDVQDECKKKGLPWT
Sbjct: 61  MPAYTRNLHHELELGVVMGKRCRAVPEAAAMDYVGGYALCLDMTARDVQDECKKKGLPWT 120

Query: 121 LAKSFTASCPVSAFVPKEKIPDPHKLKLWLKVNGELRQEGETSSMIFSIPYIISYVSKII 180
           LAKSFTASCPVSAFVPKEKIPDPHKLKLWLKVNGELRQEGETSSMIFSIPYIISYVSKII
Sbjct: 121 LAKSFTASCPVSAFVPKEKIPDPHKLKLWLKVNGELRQEGETSSMIFSIPYIISYVSKII 180

Query: 181 TLEEGDIILTGTPKGVGPVKENDEIEAGIHGL 212
           TLEEGDIILTGTPKGVGPVKENDEIEAGIHGL
Sbjct: 181 TLEEGDIILTGTPKGVGPVKENDEIEAGIHGL 212


>gi|66348062 fumarylacetoacetate hydrolase domain containing 1
           isoform 1 [Homo sapiens]
          Length = 248

 Score =  435 bits (1118), Expect = e-122
 Identities = 212/212 (100%), Positives = 212/212 (100%)

Query: 1   MGIMAASRPLSRFWEWGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSPIL 60
           MGIMAASRPLSRFWEWGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSPIL
Sbjct: 1   MGIMAASRPLSRFWEWGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSPIL 60

Query: 61  MPAYTRNLHHELELGVVMGKRCRAVPEAAAMDYVGGYALCLDMTARDVQDECKKKGLPWT 120
           MPAYTRNLHHELELGVVMGKRCRAVPEAAAMDYVGGYALCLDMTARDVQDECKKKGLPWT
Sbjct: 61  MPAYTRNLHHELELGVVMGKRCRAVPEAAAMDYVGGYALCLDMTARDVQDECKKKGLPWT 120

Query: 121 LAKSFTASCPVSAFVPKEKIPDPHKLKLWLKVNGELRQEGETSSMIFSIPYIISYVSKII 180
           LAKSFTASCPVSAFVPKEKIPDPHKLKLWLKVNGELRQEGETSSMIFSIPYIISYVSKII
Sbjct: 121 LAKSFTASCPVSAFVPKEKIPDPHKLKLWLKVNGELRQEGETSSMIFSIPYIISYVSKII 180

Query: 181 TLEEGDIILTGTPKGVGPVKENDEIEAGIHGL 212
           TLEEGDIILTGTPKGVGPVKENDEIEAGIHGL
Sbjct: 181 TLEEGDIILTGTPKGVGPVKENDEIEAGIHGL 212


>gi|156231349 fumarylacetoacetate hydrolase domain containing 2A
           [Homo sapiens]
          Length = 314

 Score =  145 bits (367), Expect = 2e-35
 Identities = 77/201 (38%), Positives = 120/201 (59%), Gaps = 10/201 (4%)

Query: 20  IVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSPILMPAYTRNLHHELELGVVMG 79
           +VCVG NY DH +E    V  EP++F K +++       +++P  ++ +  E+EL VV+G
Sbjct: 108 VVCVGMNYVDHCKEQNVPVPKEPIIFSKFASSIVGPYDEVVLPPQSQEVDWEVELAVVIG 167

Query: 80  KRCRAVPEAAAMDYVGGYALCLDMTARDVQDECKKKGLPWTLAKSFTASCPVS-AFVPKE 138
           K+ + +    AM +V G+ +  D++ARD Q   ++ G  W L K+F   CP+  A V K+
Sbjct: 168 KKGKHIKATDAMAHVAGFTVAHDVSARDWQ--MRRNGKQWLLGKTFDTFCPLGPALVTKD 225

Query: 139 KIPDPHKLKLWLKVNGELRQEGETSSMIFSIPYIISYVSKIITLEEGDIILTGTPKGVG- 197
            + DPH LK+  +VNGE+ Q G T+ M+F    +I++VS+ +T   GD+ILTGTP GVG 
Sbjct: 226 SVADPHNLKICCRVNGEVVQSGNTNQMVFKTEDLIAWVSQFVTFYPGDVILTGTPPGVGV 285

Query: 198 ----PV--KENDEIEAGIHGL 212
               PV  K+ DE++  I  L
Sbjct: 286 FRKPPVFLKKGDEVQCEIEEL 306


>gi|40786394 fumarylacetoacetate hydrolase domain containing 2B
           [Homo sapiens]
          Length = 314

 Score =  144 bits (362), Expect = 8e-35
 Identities = 76/205 (37%), Positives = 119/205 (58%), Gaps = 10/205 (4%)

Query: 16  WGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSPILMPAYTRNLHHELELG 75
           W   +VCVG NY DH +E    V  EP++F K +++       +++P  ++ +  E+EL 
Sbjct: 104 WPDKVVCVGMNYVDHCKEQNVPVPKEPIIFSKFASSIVGPYDEVVLPPQSQEVDWEVELA 163

Query: 76  VVMGKRCRAVPEAAAMDYVGGYALCLDMTARDVQDECKKKGLPWTLAKSFTASCPVS-AF 134
           VV+GK+ + +    AM +V G+ +  D++ARD     ++ G  W L K+F   CP+  A 
Sbjct: 164 VVIGKKGKHIKATDAMAHVAGFTVAHDVSARDWLT--RRNGKQWLLGKTFDTFCPLGPAL 221

Query: 135 VPKEKIPDPHKLKLWLKVNGELRQEGETSSMIFSIPYIISYVSKIITLEEGDIILTGTPK 194
           V K+ + DPH LK+  +VNGE+ Q   T+ M+F    +I++VS+ +T   GD+ILTGTP 
Sbjct: 222 VTKDSVADPHNLKICCRVNGEVVQSSNTNQMVFKTEDLIAWVSQFVTFYPGDVILTGTPP 281

Query: 195 GVG-----PV--KENDEIEAGIHGL 212
           GVG     PV  K+ DE++  I  L
Sbjct: 282 GVGVFRKPPVFLKKGDEVQCEIEEL 306


>gi|4885503 myosin IA [Homo sapiens]
          Length = 1043

 Score = 29.6 bits (65), Expect = 2.2
 Identities = 10/25 (40%), Positives = 18/25 (72%)

Query: 101 LDMTARDVQDECKKKGLPWTLAKSF 125
           ++MT ++ Q+E K++G+PWT    F
Sbjct: 409 IEMTLKEEQEEYKREGIPWTKVDYF 433


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 27.7 bits (60), Expect = 8.3
 Identities = 21/79 (26%), Positives = 36/79 (45%), Gaps = 12/79 (15%)

Query: 148  LWLKVNGELRQEGETSSMIFSIPYIISYVSKIITLEEGDIILTGTPKGVGPVKENDEIEA 207
            +WLK  GE+ +E E +         IS++  I TL+ G    + + K +  +K     +A
Sbjct: 6583 VWLKDRGEVIRESENTR--------ISFIDNIATLQLGSPEASNSGKYICQIKN----DA 6630

Query: 208  GIHGLPKVSSATLPVRLQE 226
            G+     V +   P R+ E
Sbjct: 6631 GMRECSAVLTVLEPARIIE 6649


>gi|213972636 tumor protein p53 binding protein 1 isoform 1 [Homo
            sapiens]
          Length = 1977

 Score = 27.7 bits (60), Expect = 8.3
 Identities = 19/66 (28%), Positives = 25/66 (37%)

Query: 99   LCLDMTARDVQDECKKKGLPWTLAKSFTASCPVSAFVPKEKIPDPHKLKLWLKVNGELRQ 158
            LCL M     + E  ++ L + L K  T      +    E +  P K    L    E RQ
Sbjct: 990  LCLRMKLVSPETEASEESLQFNLEKPATGERKNGSTAVAESVASPQKTMSVLSCICEARQ 1049

Query: 159  EGETSS 164
            E E  S
Sbjct: 1050 ENEARS 1055


>gi|213972634 tumor protein p53 binding protein 1 isoform 2 [Homo
            sapiens]
          Length = 1975

 Score = 27.7 bits (60), Expect = 8.3
 Identities = 19/66 (28%), Positives = 25/66 (37%)

Query: 99   LCLDMTARDVQDECKKKGLPWTLAKSFTASCPVSAFVPKEKIPDPHKLKLWLKVNGELRQ 158
            LCL M     + E  ++ L + L K  T      +    E +  P K    L    E RQ
Sbjct: 990  LCLRMKLVSPETEASEESLQFNLEKPATGERKNGSTAVAESVASPQKTMSVLSCICEARQ 1049

Query: 159  EGETSS 164
            E E  S
Sbjct: 1050 ENEARS 1055


>gi|5032189 tumor protein p53 binding protein 1 isoform 3 [Homo
            sapiens]
          Length = 1972

 Score = 27.7 bits (60), Expect = 8.3
 Identities = 19/66 (28%), Positives = 25/66 (37%)

Query: 99   LCLDMTARDVQDECKKKGLPWTLAKSFTASCPVSAFVPKEKIPDPHKLKLWLKVNGELRQ 158
            LCL M     + E  ++ L + L K  T      +    E +  P K    L    E RQ
Sbjct: 985  LCLRMKLVSPETEASEESLQFNLEKPATGERKNGSTAVAESVASPQKTMSVLSCICEARQ 1044

Query: 159  EGETSS 164
            E E  S
Sbjct: 1045 ENEARS 1050


>gi|219555700 leucine rich repeat containing 27 isoform a [Homo
           sapiens]
          Length = 530

 Score = 27.7 bits (60), Expect = 8.3
 Identities = 22/78 (28%), Positives = 38/78 (48%), Gaps = 1/78 (1%)

Query: 46  LKPSTAYAPEGSPILMPAYTRNLHHELELGVVMGKRCRAVPEAAAMDYVGGYALCLDMTA 105
           +KPS   +P+ S  +     RNL  +++  V+  +  R     A ++ +   A  L++ A
Sbjct: 415 MKPSKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHGQAPLEEMRKAAEDLEI-A 473

Query: 106 RDVQDECKKKGLPWTLAK 123
            ++QDE  K  L  TL K
Sbjct: 474 TELQDEVLKLKLGLTLNK 491


>gi|55741567 leucine rich repeat containing 27 isoform a [Homo
           sapiens]
          Length = 530

 Score = 27.7 bits (60), Expect = 8.3
 Identities = 22/78 (28%), Positives = 38/78 (48%), Gaps = 1/78 (1%)

Query: 46  LKPSTAYAPEGSPILMPAYTRNLHHELELGVVMGKRCRAVPEAAAMDYVGGYALCLDMTA 105
           +KPS   +P+ S  +     RNL  +++  V+  +  R     A ++ +   A  L++ A
Sbjct: 415 MKPSKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHGQAPLEEMRKAAEDLEI-A 473

Query: 106 RDVQDECKKKGLPWTLAK 123
            ++QDE  K  L  TL K
Sbjct: 474 TELQDEVLKLKLGLTLNK 491


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,054,620
Number of Sequences: 37866
Number of extensions: 418138
Number of successful extensions: 855
Number of sequences better than 10.0: 12
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 839
Number of HSP's gapped (non-prelim): 15
length of query: 226
length of database: 18,247,518
effective HSP length: 99
effective length of query: 127
effective length of database: 14,498,784
effective search space: 1841345568
effective search space used: 1841345568
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 60 (27.7 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
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