Search of human proteins with 21361358

Search of human proteins with 21361358

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21361358 serine/threonine kinase 25 [Homo sapiens]
         (426 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21361358 serine/threonine kinase 25 [Homo sapiens]                 863   0.0  
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]      608   e-174
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]       607   e-174
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo...   566   e-161
gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Hom...   436   e-122
gi|109633026 serine/threonine protein kinase MST4 isoform 3 [Hom...   405   e-113
gi|5454096 serine/threonine kinase 4 [Homo sapiens]                   306   2e-83
gi|103471999 serine/threonine kinase 3 [Homo sapiens]                 306   3e-83
gi|22035600 mitogen-activated protein kinase kinase kinase kinas...   269   3e-72
gi|15451902 mitogen-activated protein kinase kinase kinase kinas...   266   2e-71
gi|38570135 mitogen-activated protein kinase kinase kinase kinas...   265   8e-71
gi|14589909 mitogen-activated protein kinase kinase kinase kinas...   265   8e-71
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa...   259   2e-69
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa...   259   2e-69
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa...   259   2e-69
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa...   259   2e-69
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa...   259   2e-69
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa...   259   2e-69
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa...   259   2e-69
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap...   259   2e-69
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]     256   2e-68
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]     256   2e-68
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]     256   2e-68
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]      256   2e-68
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...   252   4e-67
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...   252   4e-67
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...   252   4e-67
gi|126362971 serine/threonine kinase 10 [Homo sapiens]                249   3e-66
gi|110611908 mitogen-activated protein kinase kinase kinase kina...   242   4e-64
gi|6005810 mitogen-activated protein kinase kinase kinase kinase...   242   4e-64

>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
          Length = 426

 Score =  863 bits (2229), Expect = 0.0
 Identities = 426/426 (100%), Positives = 426/426 (100%)

Query: 1   MAHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI 60
           MAHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI
Sbjct: 1   MAHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI 60

Query: 61  EDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATI 120
           EDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATI
Sbjct: 61  EDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATI 120

Query: 121 LREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPF 180
           LREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPF
Sbjct: 121 LREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPF 180

Query: 181 WMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHS 240
           WMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHS
Sbjct: 181 WMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHS 240

Query: 241 KPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESS 300
           KPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESS
Sbjct: 241 KPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESS 300

Query: 301 SEDSDIDGEAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLST 360
           SEDSDIDGEAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLST
Sbjct: 301 SEDSDIDGEAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLST 360

Query: 361 LVRPVFGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFSHNRN 420
           LVRPVFGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFSHNRN
Sbjct: 361 LVRPVFGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFSHNRN 420

Query: 421 HLTSTR 426
           HLTSTR
Sbjct: 421 HLTSTR 426


>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
          Length = 431

 Score =  608 bits (1569), Expect = e-174
 Identities = 304/411 (73%), Positives = 349/411 (84%), Gaps = 6/411 (1%)

Query: 10  QHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITV 69
           Q+ + DPEELFTKL++IGKGSFGEV+KGIDN T++VVAIKIIDLEEAEDEIEDIQQEITV
Sbjct: 14  QNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITV 73

Query: 70  LSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLD 129
           LSQCDSPY+T+Y+GSYLK TKLWIIMEYLGGGSALDLL+PGPL+ET IATILREILKGLD
Sbjct: 74  LSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLD 133

Query: 130 YLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ 189
           YLHSE+KIHRDIKAANVLLSE G+VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ
Sbjct: 134 YLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ 193

Query: 190 SAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEA 249
           SAYD KADIWSLGITAIELA+GEPP+S+LHPM+VLFLIPKN+PPTLEG +SKP KEFVEA
Sbjct: 194 SAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEA 253

Query: 250 CLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSD--ID 307
           CLNK+P FRPTAKELLKHKFI R  KKTS+LTELIDRYKRWK+E   ++SSSEDSD   D
Sbjct: 254 CLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETD 313

Query: 308 GEAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHS--SQKPAEPVKRQPRSQCLSTLVRPV 365
           G+A  G     W F  TIR      L  G    S   +   + + ++P SQCLST++ P+
Sbjct: 314 GQASGGSDSGDWIF--TIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPL 371

Query: 366 FGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFS 416
           F ELKEK +  GG++G++EEL  A  LAEE+CPGISD ++  LV+R+QR+S
Sbjct: 372 FAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYS 422


>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
          Length = 443

 Score =  607 bits (1565), Expect = e-174
 Identities = 303/408 (74%), Positives = 347/408 (85%), Gaps = 6/408 (1%)

Query: 13  RVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQ 72
           + DPEELFTKL++IGKGSFGEV+KGIDN T++VVAIKIIDLEEAEDEIEDIQQEITVLSQ
Sbjct: 29  KADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQ 88

Query: 73  CDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLH 132
           CDSPY+T+Y+GSYLK TKLWIIMEYLGGGSALDLL+PGPL+ET IATILREILKGLDYLH
Sbjct: 89  CDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLH 148

Query: 133 SERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAY 192
           SE+KIHRDIKAANVLLSE G+VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAY
Sbjct: 149 SEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAY 208

Query: 193 DFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLN 252
           D KADIWSLGITAIELA+GEPP+S+LHPM+VLFLIPKN+PPTLEG +SKP KEFVEACLN
Sbjct: 209 DSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLN 268

Query: 253 KDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSD--IDGEA 310
           K+P FRPTAKELLKHKFI R  KKTS+LTELIDRYKRWK+E   ++SSSEDSD   DG+A
Sbjct: 269 KEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQA 328

Query: 311 EDGEQGPIWTFPPTIRPSPHSKLHKGTALHS--SQKPAEPVKRQPRSQCLSTLVRPVFGE 368
             G     W F  TIR      L  G    S   +   + + ++P SQCLST++ P+F E
Sbjct: 329 SGGSDSGDWIF--TIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAE 386

Query: 369 LKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFS 416
           LKEK +  GG++G++EEL  A  LAEE+CPGISD ++  LV+R+QR+S
Sbjct: 387 LKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYS 434


>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
           sapiens]
          Length = 416

 Score =  566 bits (1459), Expect = e-161
 Identities = 286/408 (70%), Positives = 335/408 (82%), Gaps = 11/408 (2%)

Query: 10  QHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITV 69
           Q++  DPEELFTKL+RIGKGSFGEV+KGIDN T++VVAIKIIDLEEAEDEIEDIQQEITV
Sbjct: 14  QNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITV 73

Query: 70  LSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLD 129
           LSQCDS Y+T+Y+GSYLK +KLWIIMEYLGGGSALDLL+ GP +E  IAT+L+EILKGLD
Sbjct: 74  LSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLD 133

Query: 130 YLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ 189
           YLHSE+KIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI+Q
Sbjct: 134 YLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQ 193

Query: 190 SAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEA 249
           SAYD KADIWSLGITAIELAKGEPPNSD+HPMRVLFLIPKN+PPTL G  +K FKEF++A
Sbjct: 194 SAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDA 253

Query: 250 CLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHG-EESSSEDSDIDG 308
           CLNKDP FRPTAKELLKHKFI + +KKTS+LTELIDR+KRWK+EGH  +ES SE SD + 
Sbjct: 254 CLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSES 313

Query: 309 EAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLSTLVRPVFGE 368
            + +    P W+F  T+R  P  K          Q  AE    Q  S CLS ++ P F E
Sbjct: 314 TSRENNTHPEWSF-TTVRKKPDPK--------KVQNGAEQDLVQTLS-CLSMIITPAFAE 363

Query: 369 LKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFS 416
           LK++ + +     A+EELE + ++AE +CPGI+DK++  L+E+ Q+ S
Sbjct: 364 LKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCS 411


>gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Homo
           sapiens]
          Length = 339

 Score =  436 bits (1120), Expect = e-122
 Identities = 221/332 (66%), Positives = 263/332 (79%), Gaps = 11/332 (3%)

Query: 86  LKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAAN 145
           ++ +KLWIIMEYLGGGSALDLL+ GP +E  IAT+L+EILKGLDYLHSE+KIHRDIKAAN
Sbjct: 13  MQGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN 72

Query: 146 VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITA 205
           VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI+QSAYD KADIWSLGITA
Sbjct: 73  VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITA 132

Query: 206 IELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELL 265
           IELAKGEPPNSD+HPMRVLFLIPKN+PPTL G  +K FKEF++ACLNKDP FRPTAKELL
Sbjct: 133 IELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELL 192

Query: 266 KHKFITRYTKKTSFLTELIDRYKRWKSEGHG-EESSSEDSDIDGEAEDGEQGPIWTFPPT 324
           KHKFI + +KKTS+LTELIDR+KRWK+EGH  +ES SE SD +  + +    P W+F  T
Sbjct: 193 KHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSF-TT 251

Query: 325 IRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLSTLVRPVFGELKEKHKQSGGSVGALE 384
           +R  P  K          Q  AE    Q  S CLS ++ P F ELK++ + +     A+E
Sbjct: 252 VRKKPDPK--------KVQNGAEQDLVQTLS-CLSMIITPAFAELKQQDENNASRNQAIE 302

Query: 385 ELENAFSLAEESCPGISDKLMVHLVERVQRFS 416
           ELE + ++AE +CPGI+DK++  L+E+ Q+ S
Sbjct: 303 ELEKSIAVAEAACPGITDKMVKKLIEKFQKCS 334


>gi|109633026 serine/threonine protein kinase MST4 isoform 3 [Homo
           sapiens]
          Length = 354

 Score =  405 bits (1042), Expect = e-113
 Identities = 230/408 (56%), Positives = 273/408 (66%), Gaps = 73/408 (17%)

Query: 10  QHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITV 69
           Q++  DPEELFTKL+RIGKGSFGEV+KGIDN T++VVAIKIIDLEEAEDEIEDIQQEITV
Sbjct: 14  QNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITV 73

Query: 70  LSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLD 129
           LSQCDS Y+T+Y+GSYLK +KLWIIMEYLGGGSALDLL+ GP +E  IAT+L+EILKGLD
Sbjct: 74  LSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLD 133

Query: 130 YLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ 189
           YLHSE+KIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI+Q
Sbjct: 134 YLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQ 193

Query: 190 SAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEA 249
           SAYD K        TA EL K +              I KNS                  
Sbjct: 194 SAYDSKRP------TAKELLKHK-------------FIVKNS------------------ 216

Query: 250 CLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHG-EESSSEDSDIDG 308
                                    KKTS+LTELIDR+KRWK+EGH  +ES SE SD + 
Sbjct: 217 -------------------------KKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSES 251

Query: 309 EAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLSTLVRPVFGE 368
            + +    P W+F  T+R  P  K          Q  AE    Q  S CLS ++ P F E
Sbjct: 252 TSRENNTHPEWSF-TTVRKKPDPK--------KVQNGAEQDLVQTLS-CLSMIITPAFAE 301

Query: 369 LKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFS 416
           LK++ + +     A+EELE + ++AE +CPGI+DK++  L+E+ Q+ S
Sbjct: 302 LKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCS 349


>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
          Length = 487

 Score =  306 bits (784), Expect = 2e-83
 Identities = 156/307 (50%), Positives = 213/307 (69%), Gaps = 13/307 (4%)

Query: 16  PEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 75
           PEE+F  L+++G+GS+G VYK I   T ++VAIK + +E    ++++I +EI+++ QCDS
Sbjct: 26  PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES---DLQEIIKEISIMQQCDS 82

Query: 76  PYITRYFGSYLKSTKLWIIMEYLGGGSALDL--LKPGPLEETYIATILREILKGLDYLHS 133
           P++ +Y+GSY K+T LWI+MEY G GS  D+  L+   L E  IATIL+  LKGL+YLH 
Sbjct: 83  PHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHF 142

Query: 134 ERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYD 193
            RKIHRDIKA N+LL+ +G  KLADFGVAGQLTDT  KRNT +GTPFWMAPEVI++  Y+
Sbjct: 143 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 202

Query: 194 FKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH--SKPFKEFVEACL 251
             ADIWSLGITAIE+A+G+PP +D+HPMR +F+IP N PPT       S  F +FV+ CL
Sbjct: 203 CVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCL 262

Query: 252 NKDPRFRPTAKELLKHKFITRYTKKTSFLTELID-----RYKRWKSEGHGEESSSEDSDI 306
            K P  R TA +LL+H F+ R  K  S L +LI+     + KR +S+    +   E++  
Sbjct: 263 VKSPEQRATATQLLQHPFV-RSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSE 321

Query: 307 DGEAEDG 313
           + E + G
Sbjct: 322 EDEMDSG 328


>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
          Length = 491

 Score =  306 bits (783), Expect = 3e-83
 Identities = 154/301 (51%), Positives = 210/301 (69%), Gaps = 8/301 (2%)

Query: 16  PEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 75
           PEE+F  L+++G+GS+G V+K I   + +VVAIK + +E    ++++I +EI+++ QCDS
Sbjct: 23  PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES---DLQEIIKEISIMQQCDS 79

Query: 76  PYITRYFGSYLKSTKLWIIMEYLGGGSALDL--LKPGPLEETYIATILREILKGLDYLHS 133
           PY+ +Y+GSY K+T LWI+MEY G GS  D+  L+   L E  IATIL+  LKGL+YLH 
Sbjct: 80  PYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 139

Query: 134 ERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYD 193
            RKIHRDIKA N+LL+ +G  KLADFGVAGQLTDT  KRNT +GTPFWMAPEVI++  Y+
Sbjct: 140 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 199

Query: 194 FKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH--SKPFKEFVEACL 251
             ADIWSLGIT+IE+A+G+PP +D+HPMR +F+IP N PPT       S  F +FV+ CL
Sbjct: 200 CVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCL 259

Query: 252 NKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAE 311
            K+P  R TA +LL+H FI +  K  S L +LI      K++ H E+    + + +   E
Sbjct: 260 VKNPEQRATATQLLQHPFI-KNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDE 318

Query: 312 D 312
           D
Sbjct: 319 D 319


>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
           [Homo sapiens]
          Length = 820

 Score =  269 bits (688), Expect = 3e-72
 Identities = 154/341 (45%), Positives = 217/341 (63%), Gaps = 25/341 (7%)

Query: 1   MAHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI 60
           MA LR  + Q    DP + F  L R+G G++G+VYK  D  T E+ A+KI+ L+  +D I
Sbjct: 1   MALLRDVSLQ----DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDD-I 55

Query: 61  EDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKP-GPLEETYIAT 119
             +QQEIT+L +C  P +  Y GSYL++ +LWI ME+ GGGS  ++    GPLEE  IA 
Sbjct: 56  SSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAY 115

Query: 120 ILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTP 179
           + RE LKGL +LHS+ KIHRDIK AN+LL+ QGDVKLADFGV+G+LT +  KR +F+GTP
Sbjct: 116 VCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTP 175

Query: 180 FWMAPEVI---KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNS--PPT 234
           +WMAPEV    ++  Y+   D+W+LGITAIEL + +PP   LHPMR L L+ K+S  PP 
Sbjct: 176 YWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPK 235

Query: 235 L--EGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKS 292
           L  + + ++ F  F++  L K+P+ RPTA++LL+H F T+   + + LT+L+D+     S
Sbjct: 236 LRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPR-ALLTQLLDK----AS 290

Query: 293 EGHGEESSSEDSDI-------DGEAEDGEQGPIWTFPPTIR 326
           + H    S ED ++       D     G+ GP    P  I+
Sbjct: 291 DPHLGTPSPEDCELETYDMFPDTIHSRGQHGPAERTPSEIQ 331


>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
           [Homo sapiens]
          Length = 894

 Score =  266 bits (681), Expect = 2e-71
 Identities = 142/283 (50%), Positives = 195/283 (68%), Gaps = 10/283 (3%)

Query: 12  SRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLS 71
           SR +P+E F  + RIG G++G+VYK  + +T E+ AIK+I LE  ED    +QQEI ++ 
Sbjct: 8   SRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED-FAVVQQEIIMMK 66

Query: 72  QCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK-PGPLEETYIATILREILKGLDY 130
            C  P I  YFGSYL+  KLWI ME+ GGGS  D+    GPL E  IA + RE L+GL Y
Sbjct: 67  DCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYY 126

Query: 131 LHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI--- 187
           LHS+ K+HRDIK AN+LL++ G VKLADFGV+ Q+T T  KR +F+GTP+WMAPEV    
Sbjct: 127 LHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE 186

Query: 188 KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNS--PPTLEG--QHSKPF 243
           ++  Y+   D+W++GITAIELA+ +PP  DLHPMR LFL+ K++  PP L+   + S  F
Sbjct: 187 RKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSF 246

Query: 244 KEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDR 286
             FV+  L K+P+ RPTA++LL+H F+T++  + S   EL+D+
Sbjct: 247 HHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTR-SLAIELLDK 288


>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score =  265 bits (676), Expect = 8e-71
 Identities = 141/299 (47%), Positives = 193/299 (64%), Gaps = 9/299 (3%)

Query: 13  RVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQ 72
           R +P++ +  + R+G G++G+VYK  + HT E+ A+KII LE  +D    IQQEI ++ +
Sbjct: 13  RRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVKE 71

Query: 73  CDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK-PGPLEETYIATILREILKGLDYL 131
           C    I  YFGSYL   KLWI MEY GGGS  D+    GPL E  IA + RE L+GL YL
Sbjct: 72  CKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYL 131

Query: 132 HSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---K 188
           H++ K+HRDIK AN+LL++ GDVKLADFGVA ++T T  KR +F+GTP+WMAPEV    K
Sbjct: 132 HTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEK 191

Query: 189 QSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNS--PPTLEG--QHSKPFK 244
              Y+   DIW++GITAIEL + +PP  DLHPMR LFL+ K++  PP L+   + S  F 
Sbjct: 192 NGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFH 251

Query: 245 EFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSED 303
            FV+  L K+P+ RPTA+ LL H F+ +     +   EL+D+     +  H  E+  +D
Sbjct: 252 NFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDD 310


>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score =  265 bits (676), Expect = 8e-71
 Identities = 141/299 (47%), Positives = 193/299 (64%), Gaps = 9/299 (3%)

Query: 13  RVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQ 72
           R +P++ +  + R+G G++G+VYK  + HT E+ A+KII LE  +D    IQQEI ++ +
Sbjct: 13  RRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVKE 71

Query: 73  CDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK-PGPLEETYIATILREILKGLDYL 131
           C    I  YFGSYL   KLWI MEY GGGS  D+    GPL E  IA + RE L+GL YL
Sbjct: 72  CKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYL 131

Query: 132 HSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---K 188
           H++ K+HRDIK AN+LL++ GDVKLADFGVA ++T T  KR +F+GTP+WMAPEV    K
Sbjct: 132 HTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEK 191

Query: 189 QSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNS--PPTLEG--QHSKPFK 244
              Y+   DIW++GITAIEL + +PP  DLHPMR LFL+ K++  PP L+   + S  F 
Sbjct: 192 NGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFH 251

Query: 245 EFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSED 303
            FV+  L K+P+ RPTA+ LL H F+ +     +   EL+D+     +  H  E+  +D
Sbjct: 252 NFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDD 310


>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
           sapiens]
          Length = 1268

 Score =  259 bits (663), Expect = 2e-69
 Identities = 142/319 (44%), Positives = 202/319 (63%), Gaps = 19/319 (5%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+    DE E+I+QEI +L +  
Sbjct: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77

Query: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
               I  Y+G+++K        +LW++ME+ G GS  DL+K      L+E +IA I REI
Sbjct: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137

Query: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
           L+GL +LH  + IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
           EVI       + YDFK+D+WSLGITAIE+A+G PP  D+HPMR LFLIP+N  P L+ + 
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257

Query: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSE-GHGE 297
            SK F+ F+E+CL K+   RP  ++L+KH FI     +     +L D   R K + G  +
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317

Query: 298 ESSSEDSDIDGEAEDGEQG 316
           E+  E S  + E E+ + G
Sbjct: 318 ETEYEYSGSEEEEEENDSG 336


>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
           sapiens]
          Length = 1276

 Score =  259 bits (663), Expect = 2e-69
 Identities = 142/319 (44%), Positives = 202/319 (63%), Gaps = 19/319 (5%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+    DE E+I+QEI +L +  
Sbjct: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77

Query: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
               I  Y+G+++K        +LW++ME+ G GS  DL+K      L+E +IA I REI
Sbjct: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137

Query: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
           L+GL +LH  + IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
           EVI       + YDFK+D+WSLGITAIE+A+G PP  D+HPMR LFLIP+N  P L+ + 
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257

Query: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSE-GHGE 297
            SK F+ F+E+CL K+   RP  ++L+KH FI     +     +L D   R K + G  +
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317

Query: 298 ESSSEDSDIDGEAEDGEQG 316
           E+  E S  + E E+ + G
Sbjct: 318 ETEYEYSGSEEEEEENDSG 336


>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
           sapiens]
          Length = 1297

 Score =  259 bits (663), Expect = 2e-69
 Identities = 142/319 (44%), Positives = 202/319 (63%), Gaps = 19/319 (5%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+    DE E+I+QEI +L +  
Sbjct: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77

Query: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
               I  Y+G+++K        +LW++ME+ G GS  DL+K      L+E +IA I REI
Sbjct: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137

Query: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
           L+GL +LH  + IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
           EVI       + YDFK+D+WSLGITAIE+A+G PP  D+HPMR LFLIP+N  P L+ + 
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257

Query: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSE-GHGE 297
            SK F+ F+E+CL K+   RP  ++L+KH FI     +     +L D   R K + G  +
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317

Query: 298 ESSSEDSDIDGEAEDGEQG 316
           E+  E S  + E E+ + G
Sbjct: 318 ETEYEYSGSEEEEEENDSG 336


>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
           sapiens]
          Length = 1305

 Score =  259 bits (663), Expect = 2e-69
 Identities = 142/319 (44%), Positives = 202/319 (63%), Gaps = 19/319 (5%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+    DE E+I+QEI +L +  
Sbjct: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77

Query: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
               I  Y+G+++K        +LW++ME+ G GS  DL+K      L+E +IA I REI
Sbjct: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137

Query: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
           L+GL +LH  + IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
           EVI       + YDFK+D+WSLGITAIE+A+G PP  D+HPMR LFLIP+N  P L+ + 
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257

Query: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSE-GHGE 297
            SK F+ F+E+CL K+   RP  ++L+KH FI     +     +L D   R K + G  +
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317

Query: 298 ESSSEDSDIDGEAEDGEQG 316
           E+  E S  + E E+ + G
Sbjct: 318 ETEYEYSGSEEEEEENDSG 336


>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
           sapiens]
          Length = 1323

 Score =  259 bits (663), Expect = 2e-69
 Identities = 142/319 (44%), Positives = 202/319 (63%), Gaps = 19/319 (5%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+    DE E+I+QEI +L +  
Sbjct: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77

Query: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
               I  Y+G+++K        +LW++ME+ G GS  DL+K      L+E +IA I REI
Sbjct: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137

Query: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
           L+GL +LH  + IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
           EVI       + YDFK+D+WSLGITAIE+A+G PP  D+HPMR LFLIP+N  P L+ + 
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257

Query: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSE-GHGE 297
            SK F+ F+E+CL K+   RP  ++L+KH FI     +     +L D   R K + G  +
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317

Query: 298 ESSSEDSDIDGEAEDGEQG 316
           E+  E S  + E E+ + G
Sbjct: 318 ETEYEYSGSEEEEEENDSG 336


>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
           sapiens]
          Length = 1331

 Score =  259 bits (663), Expect = 2e-69
 Identities = 142/319 (44%), Positives = 202/319 (63%), Gaps = 19/319 (5%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+    DE E+I+QEI +L +  
Sbjct: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77

Query: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
               I  Y+G+++K        +LW++ME+ G GS  DL+K      L+E +IA I REI
Sbjct: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137

Query: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
           L+GL +LH  + IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
           EVI       + YDFK+D+WSLGITAIE+A+G PP  D+HPMR LFLIP+N  P L+ + 
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257

Query: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSE-GHGE 297
            SK F+ F+E+CL K+   RP  ++L+KH FI     +     +L D   R K + G  +
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317

Query: 298 ESSSEDSDIDGEAEDGEQG 316
           E+  E S  + E E+ + G
Sbjct: 318 ETEYEYSGSEEEEEENDSG 336


>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
           sapiens]
          Length = 1352

 Score =  259 bits (663), Expect = 2e-69
 Identities = 142/319 (44%), Positives = 202/319 (63%), Gaps = 19/319 (5%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+    DE E+I+QEI +L +  
Sbjct: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77

Query: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
               I  Y+G+++K        +LW++ME+ G GS  DL+K      L+E +IA I REI
Sbjct: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137

Query: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
           L+GL +LH  + IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
           EVI       + YDFK+D+WSLGITAIE+A+G PP  D+HPMR LFLIP+N  P L+ + 
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257

Query: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSE-GHGE 297
            SK F+ F+E+CL K+   RP  ++L+KH FI     +     +L D   R K + G  +
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317

Query: 298 ESSSEDSDIDGEAEDGEQG 316
           E+  E S  + E E+ + G
Sbjct: 318 ETEYEYSGSEEEEEENDSG 336


>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
           sapiens]
          Length = 1360

 Score =  259 bits (663), Expect = 2e-69
 Identities = 142/319 (44%), Positives = 202/319 (63%), Gaps = 19/319 (5%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+    DE E+I+QEI +L +  
Sbjct: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77

Query: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
               I  Y+G+++K        +LW++ME+ G GS  DL+K      L+E +IA I REI
Sbjct: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137

Query: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
           L+GL +LH  + IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
           EVI       + YDFK+D+WSLGITAIE+A+G PP  D+HPMR LFLIP+N  P L+ + 
Sbjct: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257

Query: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSE-GHGE 297
            SK F+ F+E+CL K+   RP  ++L+KH FI     +     +L D   R K + G  +
Sbjct: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317

Query: 298 ESSSEDSDIDGEAEDGEQG 316
           E+  E S  + E E+ + G
Sbjct: 318 ETEYEYSGSEEEEEENDSG 336


>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
          Length = 1312

 Score =  256 bits (655), Expect = 2e-68
 Identities = 145/329 (44%), Positives = 203/329 (61%), Gaps = 23/329 (6%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+   EDE E+I+QEI +L +  
Sbjct: 20  DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77

Query: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
               I  Y+G+++K +      +LW++ME+ G GS  DL+K      L+E  IA I REI
Sbjct: 78  HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137

Query: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
           L+GL +LH+ + IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
           EVI       + YD+++DIWSLGITAIE+A+G PP  D+HPMR LFLIP+N PP L+ + 
Sbjct: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257

Query: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELID-----RYKRWKSE 293
            SK F +F++ CL K    RP  ++LLK  FI     +     +L D     R KR + E
Sbjct: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317

Query: 294 GHGEESSSEDSDIDGEAEDGEQGPIWTFP 322
               E S  + + D   E+GE   I   P
Sbjct: 318 ETEYEYSGSEEEDDSHGEEGEPSSIMNVP 346


>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
          Length = 1303

 Score =  256 bits (655), Expect = 2e-68
 Identities = 145/329 (44%), Positives = 203/329 (61%), Gaps = 23/329 (6%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+   EDE E+I+QEI +L +  
Sbjct: 20  DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77

Query: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
               I  Y+G+++K +      +LW++ME+ G GS  DL+K      L+E  IA I REI
Sbjct: 78  HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137

Query: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
           L+GL +LH+ + IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
           EVI       + YD+++DIWSLGITAIE+A+G PP  D+HPMR LFLIP+N PP L+ + 
Sbjct: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257

Query: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELID-----RYKRWKSE 293
            SK F +F++ CL K    RP  ++LLK  FI     +     +L D     R KR + E
Sbjct: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317

Query: 294 GHGEESSSEDSDIDGEAEDGEQGPIWTFP 322
               E S  + + D   E+GE   I   P
Sbjct: 318 ETEYEYSGSEEEDDSHGEEGEPSSIMNVP 346


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score =  256 bits (655), Expect = 2e-68
 Identities = 145/329 (44%), Positives = 203/329 (61%), Gaps = 23/329 (6%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+   EDE E+I+QEI +L +  
Sbjct: 20  DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77

Query: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
               I  Y+G+++K +      +LW++ME+ G GS  DL+K      L+E  IA I REI
Sbjct: 78  HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137

Query: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
           L+GL +LH+ + IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
           EVI       + YD+++DIWSLGITAIE+A+G PP  D+HPMR LFLIP+N PP L+ + 
Sbjct: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257

Query: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELID-----RYKRWKSE 293
            SK F +F++ CL K    RP  ++LLK  FI     +     +L D     R KR + E
Sbjct: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317

Query: 294 GHGEESSSEDSDIDGEAEDGEQGPIWTFP 322
               E S  + + D   E+GE   I   P
Sbjct: 318 ETEYEYSGSEEEDDSHGEEGEPSSIMNVP 346


>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
          Length = 1295

 Score =  256 bits (655), Expect = 2e-68
 Identities = 145/329 (44%), Positives = 203/329 (61%), Gaps = 23/329 (6%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+   EDE E+I+QEI +L +  
Sbjct: 20  DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77

Query: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
               I  Y+G+++K +      +LW++ME+ G GS  DL+K      L+E  IA I REI
Sbjct: 78  HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137

Query: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
           L+GL +LH+ + IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
           EVI       + YD+++DIWSLGITAIE+A+G PP  D+HPMR LFLIP+N PP L+ + 
Sbjct: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257

Query: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELID-----RYKRWKSE 293
            SK F +F++ CL K    RP  ++LLK  FI     +     +L D     R KR + E
Sbjct: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317

Query: 294 GHGEESSSEDSDIDGEAEDGEQGPIWTFP 322
               E S  + + D   E+GE   I   P
Sbjct: 318 ETEYEYSGSEEEDDSHGEEGEPSSIMNVP 346


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 3 [Homo sapiens]
          Length = 1212

 Score =  252 bits (644), Expect = 4e-67
 Identities = 143/330 (43%), Positives = 202/330 (61%), Gaps = 24/330 (7%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+   EDE E+I+ EI +L +  
Sbjct: 20  DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINMLKKYS 77

Query: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
               I  Y+G+++K +      +LW++ME+ G GS  DL+K      L+E +IA I REI
Sbjct: 78  HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137

Query: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
           L+GL +LH    IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
           EVI       + YD+++D+WS GITAIE+A+G PP  D+HPMR LFLIP+N PP L+ + 
Sbjct: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257

Query: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRW------KS 292
            SK F  F+E CL K+   RP+ ++LLKH FI     +     +L D   R       K 
Sbjct: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKD 317

Query: 293 EGHGEESSSEDSDIDGEAEDGEQGPIWTFP 322
           E   E S SE+ + +   ++GE   I   P
Sbjct: 318 ETEYEYSGSEEEEEEVPEQEGEPSSIVNVP 347


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score =  252 bits (644), Expect = 4e-67
 Identities = 143/330 (43%), Positives = 202/330 (61%), Gaps = 24/330 (7%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+   EDE E+I+ EI +L +  
Sbjct: 20  DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINMLKKYS 77

Query: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
               I  Y+G+++K +      +LW++ME+ G GS  DL+K      L+E +IA I REI
Sbjct: 78  HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137

Query: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
           L+GL +LH    IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
           EVI       + YD+++D+WS GITAIE+A+G PP  D+HPMR LFLIP+N PP L+ + 
Sbjct: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257

Query: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRW------KS 292
            SK F  F+E CL K+   RP+ ++LLKH FI     +     +L D   R       K 
Sbjct: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKD 317

Query: 293 EGHGEESSSEDSDIDGEAEDGEQGPIWTFP 322
           E   E S SE+ + +   ++GE   I   P
Sbjct: 318 ETEYEYSGSEEEEEEVPEQEGEPSSIVNVP 347


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 2 [Homo sapiens]
          Length = 1320

 Score =  252 bits (644), Expect = 4e-67
 Identities = 143/330 (43%), Positives = 202/330 (61%), Gaps = 24/330 (7%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+   EDE E+I+ EI +L +  
Sbjct: 20  DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINMLKKYS 77

Query: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
               I  Y+G+++K +      +LW++ME+ G GS  DL+K      L+E +IA I REI
Sbjct: 78  HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137

Query: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
           L+GL +LH    IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197

Query: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
           EVI       + YD+++D+WS GITAIE+A+G PP  D+HPMR LFLIP+N PP L+ + 
Sbjct: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257

Query: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRW------KS 292
            SK F  F+E CL K+   RP+ ++LLKH FI     +     +L D   R       K 
Sbjct: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKD 317

Query: 293 EGHGEESSSEDSDIDGEAEDGEQGPIWTFP 322
           E   E S SE+ + +   ++GE   I   P
Sbjct: 318 ETEYEYSGSEEEEEEVPEQEGEPSSIVNVP 347


>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
          Length = 968

 Score =  249 bits (637), Expect = 3e-66
 Identities = 145/377 (38%), Positives = 223/377 (59%), Gaps = 18/377 (4%)

Query: 5   RGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ 64
           R + +    +DP E++  +  +G G+FG+VYK  +  T  + A K+I+ + +E+E+ED  
Sbjct: 21  REYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETK-SEEELEDYI 79

Query: 65  QEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGS--ALDLLKPGPLEETYIATILR 122
            EI +L+ CD PYI +  G+Y    KLWI++E+  GG+  A+ L     L E  I  + R
Sbjct: 80  VEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCR 139

Query: 123 EILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 182
           ++L+ L++LHS+R IHRD+KA NVL++ +GD++LADFGV+ +   T  KR++F+GTP+WM
Sbjct: 140 QMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWM 199

Query: 183 APEVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTL-- 235
           APEV+     K + YD+KADIWSLGIT IE+A+ EPP+ +L+PMRVL  I K+ PPTL  
Sbjct: 200 APEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLT 259

Query: 236 EGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSE-- 293
             + S  F++F++  L+K+P  RP+A +LL+H F++  T   + L EL+   K    E  
Sbjct: 260 PSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKA-LRELVAEAKAEVMEEI 318

Query: 294 GHGEESSSEDSDIDGEA--EDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKP---AEP 348
             G +   E+  +D  +  E+  Q      PP++      +    T L  SQ      EP
Sbjct: 319 EDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEP 378

Query: 349 VKRQPRSQCLSTLVRPV 365
             +    + L T   PV
Sbjct: 379 CSQPSGDRSLQTTSPPV 395


>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
           1 isoform 1 [Homo sapiens]
          Length = 821

 Score =  242 bits (618), Expect = 4e-64
 Identities = 123/282 (43%), Positives = 188/282 (66%), Gaps = 9/282 (3%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP + +  L R+G G++GEV+K  D  + ++VA+K++ +E  +D++  +Q+EI +L  C 
Sbjct: 12  DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCR 70

Query: 75  SPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK-PGPLEETYIATILREILKGLDYLHS 133
              I  Y GSYL   KLWI ME+ G GS  D+ +  G L E  I+ + RE+L+GL YLHS
Sbjct: 71  HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 130

Query: 134 ERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK---QS 190
           ++KIHRDIK AN+L+++ G+V+LADFG++ Q+  T  +R +F+GTP+WMAPEV     + 
Sbjct: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190

Query: 191 AYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKN--SPPTL--EGQHSKPFKEF 246
            Y+   DIWSLGITAIELA+ +PP  D+HP+RVLFL+ K+   PP L  +G+ S  F  F
Sbjct: 191 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNF 250

Query: 247 VEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYK 288
           ++  L K P+ RP+A ++L H+ +++       + +L+D+ K
Sbjct: 251 IKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLK 292


>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
           isoform 2 [Homo sapiens]
          Length = 833

 Score =  242 bits (618), Expect = 4e-64
 Identities = 123/282 (43%), Positives = 188/282 (66%), Gaps = 9/282 (3%)

Query: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
           DP + +  L R+G G++GEV+K  D  + ++VA+K++ +E  +D++  +Q+EI +L  C 
Sbjct: 12  DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCR 70

Query: 75  SPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK-PGPLEETYIATILREILKGLDYLHS 133
              I  Y GSYL   KLWI ME+ G GS  D+ +  G L E  I+ + RE+L+GL YLHS
Sbjct: 71  HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 130

Query: 134 ERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK---QS 190
           ++KIHRDIK AN+L+++ G+V+LADFG++ Q+  T  +R +F+GTP+WMAPEV     + 
Sbjct: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190

Query: 191 AYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKN--SPPTL--EGQHSKPFKEF 246
            Y+   DIWSLGITAIELA+ +PP  D+HP+RVLFL+ K+   PP L  +G+ S  F  F
Sbjct: 191 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNF 250

Query: 247 VEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYK 288
           ++  L K P+ RP+A ++L H+ +++       + +L+D+ K
Sbjct: 251 IKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLK 292


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.135    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,664,442
Number of Sequences: 37866
Number of extensions: 851720
Number of successful extensions: 5839
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 761
Number of HSP's successfully gapped in prelim test: 62
Number of HSP's that attempted gapping in prelim test: 3129
Number of HSP's gapped (non-prelim): 1003
length of query: 426
length of database: 18,247,518
effective HSP length: 105
effective length of query: 321
effective length of database: 14,271,588
effective search space: 4581179748
effective search space used: 4581179748
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.