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Search of human proteins with 21361114
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361114 solute carrier family 25 (mitochondrial carrier;
oxoglutarate carrier), member 11 [Homo sapiens]
(314 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361114 solute carrier family 25 (mitochondrial carrier; oxo... 622 e-178
gi|20149598 solute carrier family 25 (mitochondrial carrier; dic... 194 7e-50
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho... 189 2e-48
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H... 189 2e-48
gi|11225256 uncoupling protein 1 [Homo sapiens] 170 2e-42
gi|58197562 solute carrier family 25, member 30 [Homo sapiens] 164 1e-40
gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens] 163 2e-40
gi|13259541 uncoupling protein 2 [Homo sapiens] 158 7e-39
gi|46409330 solute carrier family 25, member 34 [Homo sapiens] 150 1e-36
gi|108860679 solute carrier family 25, member 27 [Homo sapiens] 149 3e-36
gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens] 140 1e-33
gi|41462412 solute carrier family 25, member 35 [Homo sapiens] 117 2e-26
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 100 1e-21
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 96 4e-20
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 96 4e-20
gi|13449279 solute carrier family 25 (mitochondrial oxodicarboxy... 96 5e-20
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ... 91 2e-18
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s... 91 2e-18
gi|21314739 solute carrier family 25, member 32 [Homo sapiens] 82 5e-16
gi|86198310 solute carrier family 25, member 29 [Homo sapiens] 82 6e-16
gi|149274607 solute carrier family 25, member 41 [Homo sapiens] 81 1e-15
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 80 2e-15
gi|48476342 solute carrier family 25, member 23 [Homo sapiens] 78 9e-15
gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 78 1e-14
gi|239755174 PREDICTED: similar to solute carrier family 25, mem... 78 1e-14
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ... 78 1e-14
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ... 78 1e-14
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ... 78 1e-14
gi|56699403 solute carrier family 25, member 25 isoform b [Homo ... 78 1e-14
gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens] 77 2e-14
>gi|21361114 solute carrier family 25 (mitochondrial carrier;
oxoglutarate carrier), member 11 [Homo sapiens]
Length = 314
Score = 622 bits (1603), Expect = e-178
Identities = 314/314 (100%), Positives = 314/314 (100%)
Query: 1 MAATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTRE 60
MAATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTRE
Sbjct: 1 MAATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTRE 60
Query: 61 YKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFL 120
YKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFL
Sbjct: 61 YKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFL 120
Query: 121 LKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTL 180
LKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTL
Sbjct: 121 LKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTL 180
Query: 181 WRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPV 240
WRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPV
Sbjct: 181 WRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPV 240
Query: 241 DIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFL 300
DIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFL
Sbjct: 241 DIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFL 300
Query: 301 EQMNKAYKRLFLSG 314
EQMNKAYKRLFLSG
Sbjct: 301 EQMNKAYKRLFLSG 314
>gi|20149598 solute carrier family 25 (mitochondrial carrier;
dicarboxylate transporter), member 10 [Homo sapiens]
Length = 287
Score = 194 bits (494), Expect = 7e-50
Identities = 110/284 (38%), Positives = 156/284 (54%), Gaps = 11/284 (3%)
Query: 24 KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTG 83
++ FGGLA GA PLDL+K +Q E K R + +++ +G+ +Y+G
Sbjct: 9 RWYFGGLASCGAACCTHPLDLLKVHLQTQQE-VKLRMTGMALR----VVRTDGILALYSG 63
Query: 84 LSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVA 143
LSA L RQ TY+ TR IY + +R+ P F K ++G +G G FVGTPA++
Sbjct: 64 LSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLV 123
Query: 144 LIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYS 203
+RM D +LP QRR Y + + L R+ REEG+ L+ G +R +V QL+ Y
Sbjct: 124 NVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYD 183
Query: 204 QSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEYKNGL 263
Q+KQ +L +GY SDNI HF AS I+G T P+D+ KTR+ N K EY+
Sbjct: 184 QAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMN-----SKGEYQGVF 238
Query: 264 DVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAY 307
+ + G + +KG P RL PHTVLTF+FLEQ+ K +
Sbjct: 239 HCAVETAKL-GPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNF 281
Score = 50.4 bits (119), Expect = 2e-06
Identities = 41/175 (23%), Positives = 69/175 (39%), Gaps = 10/175 (5%)
Query: 20 PKSVKFLFGGLAGMGATVFVQPLDLVKNRMQ--LSGEGAKTREYKTSFHALTSILKAEGL 77
P K L G ++G+ P DLV RMQ + + R Y + L + + EGL
Sbjct: 98 PFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGL 157
Query: 78 RGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVG 137
R +++G + R A T +L Y + + V AG F+
Sbjct: 158 RRLFSGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLC 217
Query: 138 TPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAV 192
P +V R+ + + Y+ VF+ + T + G L ++G +P R +
Sbjct: 218 QPLDVLKTRL-------MNSKGEYQGVFHCAVE-TAKLGPLAFYKGLVPAGIRLI 264
>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
sapiens]
Length = 325
Score = 189 bits (481), Expect = 2e-48
Identities = 114/309 (36%), Positives = 168/309 (54%), Gaps = 20/309 (6%)
Query: 2 AATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTR-- 59
+ T S G++ KP F++GGLA + A P+DL K R+Q+ G+ R
Sbjct: 29 STTVSHEMSGLNWKP--------FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFK 80
Query: 60 --EYKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPP 117
+Y+ FHAL I K EG+ +Y+G++ LLRQA+Y T ++GIY L +RL
Sbjct: 81 EIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSL-KRLFVERLEDE 139
Query: 118 GFLLKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGV 177
L+ + G+ +G + + P +V IRM A G L G + I I ++EG
Sbjct: 140 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIG------SFIDIYQQEGT 193
Query: 178 LTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAAS 237
LWRG +PT RA +V +L Y +K+ L+ SG D IL HF +S GL AS
Sbjct: 194 RGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALAS 253
Query: 238 MPVDIAKTRIQNMRMIDGKPE-YKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLT 296
PVD+ +TR+ N R I G + YK +D + K+ ++EGFF+L+KGF P + RLGP ++
Sbjct: 254 NPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIF 313
Query: 297 FIFLEQMNK 305
FI EQ+ +
Sbjct: 314 FITYEQLKR 322
>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
sapiens]
Length = 322
Score = 189 bits (481), Expect = 2e-48
Identities = 114/309 (36%), Positives = 168/309 (54%), Gaps = 20/309 (6%)
Query: 2 AATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTR-- 59
+ T S G++ KP F++GGLA + A P+DL K R+Q+ G+ R
Sbjct: 26 STTVSHEMSGLNWKP--------FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFK 77
Query: 60 --EYKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPP 117
+Y+ FHAL I K EG+ +Y+G++ LLRQA+Y T ++GIY L +RL
Sbjct: 78 EIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSL-KRLFVERLEDE 136
Query: 118 GFLLKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGV 177
L+ + G+ +G + + P +V IRM A G L G + I I ++EG
Sbjct: 137 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIG------SFIDIYQQEGT 190
Query: 178 LTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAAS 237
LWRG +PT RA +V +L Y +K+ L+ SG D IL HF +S GL AS
Sbjct: 191 RGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALAS 250
Query: 238 MPVDIAKTRIQNMRMIDGKPE-YKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLT 296
PVD+ +TR+ N R I G + YK +D + K+ ++EGFF+L+KGF P + RLGP ++
Sbjct: 251 NPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIF 310
Query: 297 FIFLEQMNK 305
FI EQ+ +
Sbjct: 311 FITYEQLKR 319
>gi|11225256 uncoupling protein 1 [Homo sapiens]
Length = 307
Score = 170 bits (430), Expect = 2e-42
Identities = 97/298 (32%), Positives = 150/298 (50%), Gaps = 7/298 (2%)
Query: 10 GGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGE--GAKTREYKTSFHA 67
GG+ V+ G+A A V PLD K R+Q+ GE + YK
Sbjct: 2 GGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGT 61
Query: 68 LTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGM 127
+T+++K EG +Y+GL AGL RQ + + R+G+Y + E LT T P K + G+
Sbjct: 62 ITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGL 121
Query: 128 TAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPT 187
T G F+G P EV +R+ A L + R Y +NA I EG+ LW+G P
Sbjct: 122 TTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPR-YTGTYNAYRIIATTEGLTGLWKGTTPN 180
Query: 188 MARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRI 247
+ R+V++N +L +Y K+ + + +D++ CH +++I+G TA S PVD+ KTR
Sbjct: 181 LMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRF 240
Query: 248 QNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
N +YK+ + KV EG + +KG P + RLG V+ F+ EQ+ +
Sbjct: 241 IN----SPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKR 294
Score = 61.6 bits (148), Expect = 9e-10
Identities = 52/198 (26%), Positives = 82/198 (41%), Gaps = 10/198 (5%)
Query: 18 TSPKSVKFLFGGLAGMGATVFV-QPLDLVKNRMQLSGE--GAKTREYKTSFHALTSILKA 74
T+P + GL G VF+ QP ++VK R+Q G K R Y +++A I
Sbjct: 109 TAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPR-YTGTYNAYRIIATT 167
Query: 75 EGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGA 134
EGL G++ G + L+R T L Y ++ E + V + AG
Sbjct: 168 EGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCAT 227
Query: 135 FVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVV 194
+ +P +V R P Q YK+V N +++ EG ++G +P+ R
Sbjct: 228 AMSSPVDVVKTRFINS---PPGQ---YKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSW 281
Query: 195 NAAQLASYSQSKQFLLDS 212
N + Q K+ L S
Sbjct: 282 NVIMFVCFEQLKRELSKS 299
>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
Length = 291
Score = 164 bits (414), Expect = 1e-40
Identities = 102/287 (35%), Positives = 154/287 (53%), Gaps = 13/287 (4%)
Query: 25 FLFGGLAGMGATVFVQPLDLVKNRMQLSGE--GAKTRE--YKTSFHALTSILKAEGLRGI 80
F++GGLA + A P+DL K R+Q+ G+ AK +E Y+ HAL I + EGL+ +
Sbjct: 9 FVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLKAL 68
Query: 81 YTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPA 140
Y+G++ +LRQA+Y T ++G Y L +RL + + G+ +G + + P
Sbjct: 69 YSGIAPAMLRQASYGTIKIGTYQSL-KRLFIERPEDETLPINVICGILSGVISSTIANPT 127
Query: 141 EVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLA 200
+V IRM A G N N I ++EG LW+G T RA +V +L
Sbjct: 128 DVLKIRMQAQSNTIQGGMIG--NFMN----IYQQEGTRGLWKGVSLTAQRAAIVVGVELP 181
Query: 201 SYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMI-DGK-PE 258
Y +K+ L+ SG D + HF +S GL AS PVD+ +TR+ N R++ DG+
Sbjct: 182 VYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQRVLRDGRCSG 241
Query: 259 YKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
Y LD L + + EGFF+L+KGF P + RLGP ++ F+ EQ+ K
Sbjct: 242 YTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKK 288
Score = 57.4 bits (137), Expect = 2e-08
Identities = 45/196 (22%), Positives = 76/196 (38%), Gaps = 10/196 (5%)
Query: 15 KPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSG---EGAKTREYKTSFHALTSI 71
+P + + G L+G+ ++ P D++K RMQ +G + +I
Sbjct: 100 RPEDETLPINVICGILSGVISSTIANPTDVLKIRMQAQSNTIQGGMIGNF-------MNI 152
Query: 72 LKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGA 131
+ EG RG++ G+S R A L +Y + + L + + T G
Sbjct: 153 YQQEGTRGLWKGVSLTAQRAAIVVGVELPVYDITKKHLILSGLMGDTVYTHFLSSFTCGL 212
Query: 132 TGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARA 191
GA P +V RM L + GY + L++ + EG L++G P R
Sbjct: 213 AGALASNPVDVVRTRMMNQRVLRDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRL 272
Query: 192 VVVNAAQLASYSQSKQ 207
N +Y Q K+
Sbjct: 273 GPWNIIFFVTYEQLKK 288
>gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]
Length = 312
Score = 163 bits (413), Expect = 2e-40
Identities = 100/304 (32%), Positives = 152/304 (50%), Gaps = 12/304 (3%)
Query: 15 KPRTSPKS--VKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEG-----AKTREYKTSFHA 67
KP P + VKFL G A A + PLD K R+Q+ GE A+ +Y+
Sbjct: 5 KPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGT 64
Query: 68 LTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGM 127
+ ++++ EG Y GL AGL RQ ++ + R+G+Y + + T + + G
Sbjct: 65 ILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGC 124
Query: 128 TAGATGAFVGTPAEVALIRMTADGRL-PADQRRGYKNVFNALIRITREEGVLTLWRGCIP 186
T GA P +V +R A L P+ R Y +A I REEGV LW+G +P
Sbjct: 125 TTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLP 184
Query: 187 TMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTR 246
+ R +VN A++ +Y K+ LLD +DN CHF ++ +G T + PVD+ KTR
Sbjct: 185 NIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTR 244
Query: 247 IQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKA 306
N +Y + LD + K+V EG + +KGFTP + RLG V+ F+ EQ+ +A
Sbjct: 245 YMN----SPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRA 300
Query: 307 YKRL 310
++
Sbjct: 301 LMKV 304
>gi|13259541 uncoupling protein 2 [Homo sapiens]
Length = 309
Score = 158 bits (399), Expect = 7e-39
Identities = 97/292 (33%), Positives = 151/292 (51%), Gaps = 15/292 (5%)
Query: 22 SVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEG------AKTREYKTSFHALTSILKAE 75
+VKFL G A A + PLD K R+Q+ GE + +Y+ + ++++ E
Sbjct: 14 TVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTE 73
Query: 76 GLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLT-GADGTPPGFLLKAVIGMTAGATGA 134
G R +Y GL AGL RQ ++ + R+G+Y + + T G++ G L A G T GA
Sbjct: 74 GPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLA--GSTTGALAV 131
Query: 135 FVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVV 194
V P +V +R A R +R Y++ NA I REEG LW+G P +AR +V
Sbjct: 132 AVAQPTDVVKVRFQAQARAGGGRR--YQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIV 189
Query: 195 NAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMID 254
N A+L +Y K LL + +D++ CHF ++ +G TT + PVD+ KTR N +
Sbjct: 190 NCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSAL-- 247
Query: 255 GKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKA 306
+Y + +++ EG + +KGF P + RLG V+ F+ EQ+ +A
Sbjct: 248 --GQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRA 297
Score = 62.0 bits (149), Expect = 7e-10
Identities = 45/189 (23%), Positives = 78/189 (41%), Gaps = 10/189 (5%)
Query: 24 KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTG 83
+ L G G A QP D+VK R Q R Y+++ +A +I + EG RG++ G
Sbjct: 119 RLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKG 178
Query: 84 LSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVA 143
S + R A L Y ++ + L A+ AG + +P +V
Sbjct: 179 TSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVV 238
Query: 144 LIRM--TADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLAS 201
R +A G+ Y + + + + ++EG ++G +P+ R N +
Sbjct: 239 KTRYMNSALGQ--------YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVT 290
Query: 202 YSQSKQFLL 210
Y Q K+ L+
Sbjct: 291 YEQLKRALM 299
>gi|46409330 solute carrier family 25, member 34 [Homo sapiens]
Length = 304
Score = 150 bits (380), Expect = 1e-36
Identities = 99/297 (33%), Positives = 155/297 (52%), Gaps = 14/297 (4%)
Query: 18 TSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGE----GAKTREYKTSFHALTSILK 73
T P +V + G A A VF PL++VK R+QL GE G R Y ++ ++ +
Sbjct: 3 TVPPAVDLVLGASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVAR 62
Query: 74 AEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATG 133
A+GL G+ GL+AGLL Q R Y++ + G P G + V G AGA G
Sbjct: 63 ADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQ--AGLTQQPGGTV---VAGAVAGALG 117
Query: 134 AFVGTPAEVALIRMTAD--GRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARA 191
AFVG+PA + ++ A + + ++ V AL I R++G+L LW+G + R
Sbjct: 118 AFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRV 177
Query: 192 VVVNAAQLASYSQSKQFLLDSGYF-SDNILCHFCASMISGLVTTAASMPVDIAKTRIQNM 250
+V +AAQLA+++ +K ++ + D+ L MIS + P D+ TR+ N
Sbjct: 178 MVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQ 237
Query: 251 RM-IDGKPEYKNGL-DVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
+ G+ + GL D + K+ R EG +L+KG P Y RLGPHT+L+ +F +++ K
Sbjct: 238 PVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRK 294
>gi|108860679 solute carrier family 25, member 27 [Homo sapiens]
Length = 323
Score = 149 bits (376), Expect = 3e-36
Identities = 94/299 (31%), Positives = 153/299 (51%), Gaps = 13/299 (4%)
Query: 20 PKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTR---------EYKTSFHALTS 70
P++ KFL G A A + PLDL K R+Q+ GE A R Y+
Sbjct: 18 PRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALG 77
Query: 71 ILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIG-MTA 129
I++ EG ++ G++ + R Y+ R+ Y L E + G L K+VIG M A
Sbjct: 78 IIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMA 137
Query: 130 GATGAFVGTPAEVALIRMTADGRLPADQRR-GYKNVFNALIRITREEGVLTLWRGCIPTM 188
G G F+ P ++ ++M +G+ + + ++ V +A +I E G+ LW G +P +
Sbjct: 138 GVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNI 197
Query: 189 ARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQ 248
RA +VN L +Y K +L+ + DNI+ H +S+ SGLV + P D+ K+RI
Sbjct: 198 QRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIM 257
Query: 249 NM-RMIDGKP-EYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
N R G+ YK+ D L + V+ EGF SL+KGF P + R+ P +++ ++ E++ +
Sbjct: 258 NQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIRE 316
>gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]
Length = 275
Score = 140 bits (354), Expect = 1e-33
Identities = 89/275 (32%), Positives = 134/275 (48%), Gaps = 12/275 (4%)
Query: 15 KPRTSPKS--VKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEG-----AKTREYKTSFHA 67
KP P + VKFL G A A + PLD K R+Q+ GE A+ +Y+
Sbjct: 5 KPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGT 64
Query: 68 LTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGM 127
+ ++++ EG Y GL AGL RQ ++ + R+G+Y + + T + + G
Sbjct: 65 ILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGC 124
Query: 128 TAGATGAFVGTPAEVALIRMTADGRL-PADQRRGYKNVFNALIRITREEGVLTLWRGCIP 186
T GA P +V +R A L P+ R Y +A I REEGV LW+G +P
Sbjct: 125 TTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLP 184
Query: 187 TMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTR 246
+ R +VN A++ +Y K+ LLD +DN CHF ++ +G T + PVD+ KTR
Sbjct: 185 NIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTR 244
Query: 247 IQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKG 281
N +Y + LD + K+V EG + +KG
Sbjct: 245 YMN----SPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
>gi|41462412 solute carrier family 25, member 35 [Homo sapiens]
Length = 295
Score = 117 bits (292), Expect = 2e-26
Identities = 79/234 (33%), Positives = 116/234 (49%), Gaps = 10/234 (4%)
Query: 25 FLFGGLAGMGATVFVQPLDLVKNRMQLSGE----GAKTREYKTSFHALTSILKAEGLRGI 80
FL GLA GA VF PL++VK RMQL GE G R Y+ FHA +I K +GL +
Sbjct: 3 FLMSGLAACGACVFTNPLEVVKTRMQLQGELQAPGTYQRHYRNVFHAFITIGKVDGLAAL 62
Query: 81 YTGLSAGLLRQATYTTTRLGIYTVLFE--RLTGADGTPPGFLLKAVIGMTAGATGAFVGT 138
GL+ LL Q RLG Y + L A+GT A G AG GA++G+
Sbjct: 63 QKGLAPALLYQFLMNGIRLGTYGLAEAGGYLHTAEGTHSP-ARSAAAGAMAGVMGAYLGS 121
Query: 139 PAEVALIRMTAD--GRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNA 196
P + + A + + ++ +F AL I ++ G++ LWRG + + R +V ++
Sbjct: 122 PIYMVKTHLQAQAASEIAVGHQYKHQGMFQALTEIGQKHGLVGLWRGALGGLPRVIVGSS 181
Query: 197 AQLASYSQSKQFLLDSGYF-SDNILCHFCASMISGLVTTAASMPVDIAKTRIQN 249
QL ++S +K L F + A+M+SG+ A P D+A TR+ N
Sbjct: 182 TQLCTFSSTKDLLSQWEIFPPQSWKLALVAAMMSGIAVVLAMAPFDVACTRLYN 235
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 100 bits (250), Expect = 1e-21
Identities = 82/300 (27%), Positives = 132/300 (44%), Gaps = 20/300 (6%)
Query: 14 GKP---RTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLS-GEGAKTRE--YKTSFHA 67
G+P + + + +F G +AG V P+DLVK RMQ G G+ E YK SF
Sbjct: 316 GRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDC 375
Query: 68 LTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGM 127
+L+ EG G+Y GL L+ A +L + + ++ T DG+ P + + G
Sbjct: 376 FKKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVP-LPAEVLAGG 434
Query: 128 TAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPT 187
AG + P E+ IR+ G + R NV R+ G+ L++G
Sbjct: 435 CAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVL-------RDLGIFGLYKGAKAC 487
Query: 188 MARAVVVNAAQLASYSQSKQFLLD-SGYFSD-NILCHFCASMISGLVTTAASMPVDIAKT 245
R + +A Y+ K L D +G+ N+L A ++G+ + P D+ KT
Sbjct: 488 FLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLL---AAGAMAGVPAASLVTPADVIKT 544
Query: 246 RIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
R+Q + G+ Y +D K++R EG + WKG R P +T + E + +
Sbjct: 545 RLQ-VAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQR 603
>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
sapiens]
Length = 675
Score = 95.9 bits (237), Expect = 4e-20
Identities = 81/304 (26%), Positives = 130/304 (42%), Gaps = 21/304 (6%)
Query: 9 AGGIDGKP---RTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQ---LSGEGAKTREYK 62
A G +P + + + +F G +AG V P+DLVK RMQ +G YK
Sbjct: 313 ASGDSARPVLLQVAESAYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYK 372
Query: 63 TSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLK 122
SF +L+ EG G+Y GL LL A +L + + ++ DG+ P +
Sbjct: 373 NSFDCFKKVLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVP-LAAE 431
Query: 123 AVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWR 182
+ G AG + P E+ IR+ G + R + + + R+ G +++
Sbjct: 432 ILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPR-------VSALSVVRDLGFFGIYK 484
Query: 183 GCIPTMARAVVVNAAQLASYSQSK-QFLLDSGYFSDNILCHFCASMISGLVTTAASMPVD 241
G R + +A Y+ K F + G S L A I+G+ + P D
Sbjct: 485 GAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSL--LLAGAIAGMPAASLVTPAD 542
Query: 242 IAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPH---TVLTFI 298
+ KTR+Q + G+ Y +D K++R EG +LWKG R P T+LT+
Sbjct: 543 VIKTRLQ-VAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYE 601
Query: 299 FLEQ 302
L++
Sbjct: 602 LLQR 605
Score = 71.2 bits (173), Expect = 1e-12
Identities = 60/204 (29%), Positives = 89/204 (43%), Gaps = 18/204 (8%)
Query: 15 KPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGE---GAKTREYKTSFHALTSI 71
K + P + + L GG AG +F PL++VK R+Q++GE G + + S+
Sbjct: 422 KDGSVPLAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRV--------SALSV 473
Query: 72 LKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADG-TPPGFLLKAVIGMTAG 130
++ G GIY G A LR ++ Y + DG PG LL A G AG
Sbjct: 474 VRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLA--GAIAG 531
Query: 131 ATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMAR 190
A + TPA+V R+ R + Y V + +I REEG LW+G + R
Sbjct: 532 MPAASLVTPADVIKTRLQVAARA---GQTTYSGVIDCFRKILREEGPKALWKGAGARVFR 588
Query: 191 AVVVNAAQLASYS-QSKQFLLDSG 213
+ L +Y + F +D G
Sbjct: 589 SSPQFGVTLLTYELLQRWFYIDFG 612
>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
sapiens]
Length = 676
Score = 95.9 bits (237), Expect = 4e-20
Identities = 81/304 (26%), Positives = 130/304 (42%), Gaps = 21/304 (6%)
Query: 9 AGGIDGKP---RTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQ---LSGEGAKTREYK 62
A G +P + + + +F G +AG V P+DLVK RMQ +G YK
Sbjct: 314 ASGDSARPVLLQVAESAYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYK 373
Query: 63 TSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLK 122
SF +L+ EG G+Y GL LL A +L + + ++ DG+ P +
Sbjct: 374 NSFDCFKKVLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVP-LAAE 432
Query: 123 AVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWR 182
+ G AG + P E+ IR+ G + R + + + R+ G +++
Sbjct: 433 ILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPR-------VSALSVVRDLGFFGIYK 485
Query: 183 GCIPTMARAVVVNAAQLASYSQSK-QFLLDSGYFSDNILCHFCASMISGLVTTAASMPVD 241
G R + +A Y+ K F + G S L A I+G+ + P D
Sbjct: 486 GAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSL--LLAGAIAGMPAASLVTPAD 543
Query: 242 IAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPH---TVLTFI 298
+ KTR+Q + G+ Y +D K++R EG +LWKG R P T+LT+
Sbjct: 544 VIKTRLQ-VAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYE 602
Query: 299 FLEQ 302
L++
Sbjct: 603 LLQR 606
Score = 71.2 bits (173), Expect = 1e-12
Identities = 60/204 (29%), Positives = 89/204 (43%), Gaps = 18/204 (8%)
Query: 15 KPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGE---GAKTREYKTSFHALTSI 71
K + P + + L GG AG +F PL++VK R+Q++GE G + + S+
Sbjct: 423 KDGSVPLAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRV--------SALSV 474
Query: 72 LKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADG-TPPGFLLKAVIGMTAG 130
++ G GIY G A LR ++ Y + DG PG LL A G AG
Sbjct: 475 VRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLA--GAIAG 532
Query: 131 ATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMAR 190
A + TPA+V R+ R + Y V + +I REEG LW+G + R
Sbjct: 533 MPAASLVTPADVIKTRLQVAARA---GQTTYSGVIDCFRKILREEGPKALWKGAGARVFR 589
Query: 191 AVVVNAAQLASYS-QSKQFLLDSG 213
+ L +Y + F +D G
Sbjct: 590 SSPQFGVTLLTYELLQRWFYIDFG 613
>gi|13449279 solute carrier family 25 (mitochondrial
oxodicarboxylate carrier), member 21 [Homo sapiens]
Length = 299
Score = 95.5 bits (236), Expect = 5e-20
Identities = 81/300 (27%), Positives = 133/300 (44%), Gaps = 21/300 (7%)
Query: 12 IDGKPRTS---PKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHAL 68
+ KP S S + + GG AG+ + PLD+VK R Q+ YK+ +
Sbjct: 1 MSAKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSF 60
Query: 69 TSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMT 128
I + EGL G Y G+ +L + + + +++L G P L A+ G+
Sbjct: 61 RMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQ-YKKLLGYVSLSPA-LTFAIAGLG 118
Query: 129 AGATGAFVGTPAEVALIRMTADGRLPADQRR--GYKNVFNALIRITREEG--VLTLWRGC 184
+G T A V P EV + + A+ A+Q GY +I ++EG + L +G
Sbjct: 119 SGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYAR------QIIKKEGWGLQGLNKGL 172
Query: 185 IPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNIL---CHFCASMISGLVTTAASMPVD 241
T+ R V N Y K + + D IL F ++SG + + ++P D
Sbjct: 173 TATLGRHGVFNMVYFGFYYNVKNMIPVN---KDPILEFWRKFGIGLLSGTIASVINIPFD 229
Query: 242 IAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLE 301
+AK+RIQ + + G+ +Y+ + V + EG +L+KG P RLGP + + E
Sbjct: 230 VAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYE 289
Score = 59.3 bits (142), Expect = 4e-09
Identities = 47/194 (24%), Positives = 87/194 (44%), Gaps = 7/194 (3%)
Query: 22 SVKFLFGGL-AGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEG--LR 78
++ F GL +G+ + V P ++VK +Q + E ++ I+K EG L+
Sbjct: 109 ALTFAIAGLGSGLTEAIVVNPFEVVKVGLQANRN--TFAEQPSTVGYARQIIKKEGWGLQ 166
Query: 79 GIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGT 138
G+ GL+A L R + G Y + + F K IG+ +G + +
Sbjct: 167 GLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINI 226
Query: 139 PAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQ 198
P +VA R+ +P + + Y+ F + + +EEG+L L++G +P + R A
Sbjct: 227 PFDVAKSRIQGPQPVPGEIK--YRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVM 284
Query: 199 LASYSQSKQFLLDS 212
L Y + +L ++
Sbjct: 285 LLVYEYTYSWLQEN 298
Score = 43.9 bits (102), Expect = 2e-04
Identities = 26/85 (30%), Positives = 36/85 (42%)
Query: 229 SGLVTTAASMPVDIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYAR 288
+GLV P+D+ KTR Q R YK+ +D + + EG F +KG P
Sbjct: 23 AGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILA 82
Query: 289 LGPHTVLTFIFLEQMNKAYKRLFLS 313
P + F EQ K + LS
Sbjct: 83 ETPKRAVKFFTFEQYKKLLGYVSLS 107
>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
sapiens]
Length = 477
Score = 90.5 bits (223), Expect = 2e-18
Identities = 65/285 (22%), Positives = 127/285 (44%), Gaps = 14/285 (4%)
Query: 24 KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTG 83
+ L GG+AG + PLD +K MQ+ G + + F ++K G+R ++ G
Sbjct: 197 QLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKS---DKMNIFGGFRQMVKEGGIRSLWRG 253
Query: 84 LSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVA 143
+++ A T + Y +++L +G G + + G AGAT P EV
Sbjct: 254 NGTNVIKIAPETAVKFWAYEQ-YKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVM 312
Query: 144 LIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYS 203
R L + Y +++ +I + EG+ ++G +P + + LA Y
Sbjct: 313 KTR------LAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYE 366
Query: 204 QSKQFLLDS---GYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEYK 260
K + LD+ + ++ +S AS P+ + +TR+Q M++G P+
Sbjct: 367 LLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQL- 425
Query: 261 NGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
N + + +++ EG L++G TP + ++ P ++++ E M +
Sbjct: 426 NMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQ 470
Score = 67.0 bits (162), Expect = 2e-11
Identities = 49/189 (25%), Positives = 74/189 (39%), Gaps = 10/189 (5%)
Query: 24 KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTG 83
+F+ G +AG A F+ P++++K R+ + KT +Y + ILK EGL Y G
Sbjct: 291 RFISGSMAGATAQTFIYPMEVMKTRLAVG----KTGQYSGIYDCAKKILKHEGLGAFYKG 346
Query: 84 LSAGLLRQATYTTTRLGIYTVLFERLT---GADGTPPGFLLKAVIGMTAGATGAFVGTPA 140
LL Y L +Y +L D PG ++ G + G P
Sbjct: 347 YVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPL 406
Query: 141 EVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLA 200
+ RM A L + +F RI +EG+ L+RG P + +
Sbjct: 407 ALVRTRMQAQAMLEGSPQLNMVGLFR---RIISKEGIPGLYRGITPNFMKVLPAVGISYV 463
Query: 201 SYSQSKQFL 209
Y KQ L
Sbjct: 464 VYENMKQTL 472
Score = 52.0 bits (123), Expect = 7e-07
Identities = 40/182 (21%), Positives = 75/182 (41%), Gaps = 11/182 (6%)
Query: 126 GMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCI 185
G AGA P + I M G + N+F ++ +E G+ +LWRG
Sbjct: 201 GGIAGAVSRTSTAPLDRLKIMMQVHG-----SKSDKMNIFGGFRQMVKEGGIRSLWRGNG 255
Query: 186 PTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKT 245
+ + A + +Y Q K+ L + G F + ++G P+++ KT
Sbjct: 256 TNVIKIAPETAVKFWAYEQYKKLLTEEGQ-KIGTFERFISGSMAGATAQTFIYPMEVMKT 314
Query: 246 RIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
R+ + +Y D K++++EG + +KG+ P + P+ + E + K
Sbjct: 315 RL----AVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELL-K 369
Query: 306 AY 307
+Y
Sbjct: 370 SY 371
>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
Length = 458
Score = 90.5 bits (223), Expect = 2e-18
Identities = 65/285 (22%), Positives = 127/285 (44%), Gaps = 14/285 (4%)
Query: 24 KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTG 83
+ L GG+AG + PLD +K MQ+ G + + F ++K G+R ++ G
Sbjct: 178 QLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKS---DKMNIFGGFRQMVKEGGIRSLWRG 234
Query: 84 LSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVA 143
+++ A T + Y +++L +G G + + G AGAT P EV
Sbjct: 235 NGTNVIKIAPETAVKFWAYEQ-YKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVM 293
Query: 144 LIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYS 203
R L + Y +++ +I + EG+ ++G +P + + LA Y
Sbjct: 294 KTR------LAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYE 347
Query: 204 QSKQFLLDS---GYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEYK 260
K + LD+ + ++ +S AS P+ + +TR+Q M++G P+
Sbjct: 348 LLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQL- 406
Query: 261 NGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
N + + +++ EG L++G TP + ++ P ++++ E M +
Sbjct: 407 NMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQ 451
Score = 67.0 bits (162), Expect = 2e-11
Identities = 49/189 (25%), Positives = 74/189 (39%), Gaps = 10/189 (5%)
Query: 24 KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTG 83
+F+ G +AG A F+ P++++K R+ + KT +Y + ILK EGL Y G
Sbjct: 272 RFISGSMAGATAQTFIYPMEVMKTRLAVG----KTGQYSGIYDCAKKILKHEGLGAFYKG 327
Query: 84 LSAGLLRQATYTTTRLGIYTVLFERLT---GADGTPPGFLLKAVIGMTAGATGAFVGTPA 140
LL Y L +Y +L D PG ++ G + G P
Sbjct: 328 YVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPL 387
Query: 141 EVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLA 200
+ RM A L + +F RI +EG+ L+RG P + +
Sbjct: 388 ALVRTRMQAQAMLEGSPQLNMVGLFR---RIISKEGIPGLYRGITPNFMKVLPAVGISYV 444
Query: 201 SYSQSKQFL 209
Y KQ L
Sbjct: 445 VYENMKQTL 453
Score = 52.0 bits (123), Expect = 7e-07
Identities = 40/182 (21%), Positives = 75/182 (41%), Gaps = 11/182 (6%)
Query: 126 GMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCI 185
G AGA P + I M G + N+F ++ +E G+ +LWRG
Sbjct: 182 GGIAGAVSRTSTAPLDRLKIMMQVHG-----SKSDKMNIFGGFRQMVKEGGIRSLWRGNG 236
Query: 186 PTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKT 245
+ + A + +Y Q K+ L + G F + ++G P+++ KT
Sbjct: 237 TNVIKIAPETAVKFWAYEQYKKLLTEEGQ-KIGTFERFISGSMAGATAQTFIYPMEVMKT 295
Query: 246 RIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
R+ + +Y D K++++EG + +KG+ P + P+ + E + K
Sbjct: 296 RL----AVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELL-K 350
Query: 306 AY 307
+Y
Sbjct: 351 SY 352
>gi|21314739 solute carrier family 25, member 32 [Homo sapiens]
Length = 315
Score = 82.4 bits (202), Expect = 5e-16
Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 25/289 (8%)
Query: 28 GGLAGMGATVFVQPLDLVKNRMQLSGEGAKTR-EYKTSFHALTSILKAEGLRGIYTGLSA 86
G G+ + + + PLDLVK R +S +G + R +Y H LT+I K +GLRG+Y G++
Sbjct: 29 GVSGGVLSNLALHPLDLVKIRFAVS-DGLELRPKYNGILHCLTTIWKLDGLRGLYQGVTP 87
Query: 87 GLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKA----VIGMTAGATGAFVGTPAEV 142
+ G+Y + + L+A V AGA + P V
Sbjct: 88 NIWGAG----LSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPLWV 143
Query: 143 ALIR-MTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIP----TMARAVVVNAA 197
R M + R YK +F+ L++I + EGV L++G +P T A+ A
Sbjct: 144 TKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTSHGALQFMAY 203
Query: 198 QL--ASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDG 255
+L Y+Q L ++ + + + + +S + AA+ P + + R+Q+ M
Sbjct: 204 ELLKLKYNQHINRLPEAQL---STVEYISVAALSKIFAVAATYPYQVVRARLQDQHMF-- 258
Query: 256 KPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMN 304
Y +DV+ K R EG +KG P R+ P +TF+ E ++
Sbjct: 259 ---YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVS 304
Score = 53.9 bits (128), Expect = 2e-07
Identities = 49/191 (25%), Positives = 71/191 (37%), Gaps = 21/191 (10%)
Query: 31 AGMGATVFVQPLDLVKNRMQLSGEGAKT---REYKTSFHALTSILKAEGLRGIYTGLSAG 87
AG PL + K R+ L + R+YK F L I K EG+RG+Y G G
Sbjct: 130 AGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPG 189
Query: 88 L-------LRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPA 140
L L+ Y +L Y RL A + ++ A + + P
Sbjct: 190 LFGTSHGALQFMAYELLKLK-YNQHINRLPEAQLSTVEYISVAALSKIFAVAATY---PY 245
Query: 141 EVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLA 200
+V R+ DQ Y V + + + R+EGV ++G P + R
Sbjct: 246 QVVRARLQ-------DQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFV 298
Query: 201 SYSQSKQFLLD 211
Y FLLD
Sbjct: 299 VYENVSHFLLD 309
Score = 35.0 bits (79), Expect = 0.086
Identities = 23/84 (27%), Positives = 40/84 (47%), Gaps = 1/84 (1%)
Query: 225 ASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTP 284
A + G+++ A P+D+ K R ++ +P+Y L L + + +G L++G TP
Sbjct: 28 AGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQGVTP 87
Query: 285 YYARLGPHTVLTFIFLEQMNKAYK 308
G L F F + K+YK
Sbjct: 88 NIWGAGLSWGLYFFFYNAI-KSYK 110
>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
Length = 303
Score = 82.0 bits (201), Expect = 6e-16
Identities = 76/279 (27%), Positives = 119/279 (42%), Gaps = 17/279 (6%)
Query: 22 SVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIY 81
++ FL G G+ + P D VK R+Q+ + + +Y+ + H SI+K E + G+Y
Sbjct: 2 ALDFLAGCAGGVAGVLVGHPFDTVKVRLQV--QSVEKPQYRGTLHCFKSIIKQESVLGLY 59
Query: 82 TGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAE 141
GL + L+ G+ R G D FL G AGA + P E
Sbjct: 60 KGLGSPLMGLTFINALVFGVQGNTL-RALGHDSPLNQFL----AGAAAGAIQCVICCPME 114
Query: 142 VALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLAS 201
+A R+ PA R YK + L +I EG+ + RG + T+ R +
Sbjct: 115 LAKTRLQLQDAGPA---RTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLT 171
Query: 202 YSQSKQFL-LDSGYFSDNILCH--FCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPE 258
Y + L + G D +L A SG+V+ ++ PVD+ K+R+Q + G P
Sbjct: 172 YDALTRALGCEPG---DRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQ-ADGLRGAPR 227
Query: 259 YKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTF 297
Y+ LD + + R EG+ +G R P TF
Sbjct: 228 YRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATF 266
Score = 53.9 bits (128), Expect = 2e-07
Identities = 47/188 (25%), Positives = 82/188 (43%), Gaps = 14/188 (7%)
Query: 121 LKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTL 180
L + G G G VG P + +R+ + Q RG + F ++I+ +E VL L
Sbjct: 3 LDFLAGCAGGVAGVLVGHPFDTVKVRLQVQS-VEKPQYRGTLHCFKSIIK---QESVLGL 58
Query: 181 WRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPV 240
++G + +NA + + L G+ D+ L F A +G + P+
Sbjct: 59 YKGLGSPLMGLTFINALVFGVQGNTLRAL---GH--DSPLNQFLAGAAAGAIQCVICCPM 113
Query: 241 DIAKTRIQNMRMIDGKPE--YKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFI 298
++AKTR+Q + D P YK LD L ++ +EG + +G R P + F+
Sbjct: 114 ELAKTRLQ---LQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFL 170
Query: 299 FLEQMNKA 306
+ + +A
Sbjct: 171 TYDALTRA 178
Score = 40.8 bits (94), Expect = 0.002
Identities = 27/93 (29%), Positives = 42/93 (45%), Gaps = 1/93 (1%)
Query: 26 LFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLS 85
L GG +G+ + + P+D+VK+R+Q G R Y+ + +AEG R GL+
Sbjct: 194 LAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPR-YRGILDCVHQSYRAEGWRVFTRGLA 252
Query: 86 AGLLRQATYTTTRLGIYTVLFERLTGADGTPPG 118
+ LLR TV+ G + P G
Sbjct: 253 STLLRAFPVNAATFATVTVVLTYARGEEAGPEG 285
>gi|149274607 solute carrier family 25, member 41 [Homo sapiens]
Length = 370
Score = 80.9 bits (198), Expect = 1e-15
Identities = 73/286 (25%), Positives = 125/286 (43%), Gaps = 17/286 (5%)
Query: 24 KFLFGG-LAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYT 82
KFL G +AG + PLD K MQ+ +KT + L S+++ G R ++
Sbjct: 94 KFLLSGAMAGAVSRTGTAPLDRAKVYMQVYS--SKTN-FTNLLGGLQSMVQEGGFRSLWR 150
Query: 83 GLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEV 142
G +L+ A + ++ G G+PP F + + G A A + P EV
Sbjct: 151 GNGINVLKIAPEYAIKFSVFEQCKNYFCGIQGSPP-FQERLLAGSLAVAISQTLINPMEV 209
Query: 143 ALIRMTADGRLPADQRRG-YKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLAS 201
R+T +R G YK + + +I + EG L+RG +P M + LA
Sbjct: 210 LKTRLTL-------RRTGQYKGLLDCARQILQREGTRALYRGYLPNMLGIIPYACTDLAV 262
Query: 202 YSQSKQFLLDSG--YFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEY 259
Y + F + SG + L + +S AS P+ + +TR+Q ++G
Sbjct: 263 YEMLQCFWVKSGRDMGDPSGLVSLSSVTLSTTCGQMASYPLTLVRTRMQAQDTVEGSNPT 322
Query: 260 KNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
G VL +++ +G+ L++G TP ++ P ++++ E M K
Sbjct: 323 MRG--VLQRILAQQGWLGLYRGMTPTLLKVLPAGGISYVVYEAMKK 366
Score = 62.4 bits (150), Expect = 5e-10
Identities = 53/202 (26%), Positives = 84/202 (41%), Gaps = 15/202 (7%)
Query: 11 GIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTS 70
GI G P P + L G LA + + P++++K R+ L +T +YK
Sbjct: 179 GIQGSP---PFQERLLAGSLAVAISQTLINPMEVLKTRLTLR----RTGQYKGLLDCARQ 231
Query: 71 ILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVL--FERLTGAD-GTPPGFLLKAVIGM 127
IL+ EG R +Y G +L Y T L +Y +L F +G D G P G + + + +
Sbjct: 232 ILQREGTRALYRGYLPNMLGIIPYACTDLAVYEMLQCFWVKSGRDMGDPSGLVSLSSVTL 291
Query: 128 TAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPT 187
+ G P + RM A + + L RI ++G L L+RG PT
Sbjct: 292 ST-TCGQMASYPLTLVRTRMQAQDTVEGSN----PTMRGVLQRILAQQGWLGLYRGMTPT 346
Query: 188 MARAVVVNAAQLASYSQSKQFL 209
+ + + Y K+ L
Sbjct: 347 LLKVLPAGGISYVVYEAMKKTL 368
>gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
Length = 311
Score = 80.1 bits (196), Expect = 2e-15
Identities = 76/316 (24%), Positives = 134/316 (42%), Gaps = 21/316 (6%)
Query: 2 AATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREY 61
A A A A GK + + L GGLAG P + VK ++QL E + Y
Sbjct: 6 APRALAAAAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLD-ERSHPPRY 64
Query: 62 KTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADG---TPPG 118
+ + +++ G+ G+Y GLS+ L R G++ L + A G + G
Sbjct: 65 RGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRG 124
Query: 119 FLLKAVIGMTAGATGAFVGT-PAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGV 177
L G+ AG A V P E ++ D P + RG+ F+ + I RE+G+
Sbjct: 125 LLC----GLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGF---FHGVREIVREQGL 177
Query: 178 LTLWRGCIPTMARAVVVNAAQLASYSQSKQFLL-DSGYFSDNILCHFCASMISGLVTTAA 236
++G T+ + A + + + + D+ N L I+G +
Sbjct: 178 KGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFG 237
Query: 237 SMPVDIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLT 296
+ P+D+ KTR+Q + +Y+N D ++++ EG + +KG P R+ +
Sbjct: 238 NTPLDVIKTRMQGLEA----HKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIV 293
Query: 297 FIFLEQ----MNKAYK 308
F+ ++ +NK +K
Sbjct: 294 FVIYDEVVKLLNKVWK 309
>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
Length = 468
Score = 78.2 bits (191), Expect = 9e-15
Identities = 74/284 (26%), Positives = 122/284 (42%), Gaps = 18/284 (6%)
Query: 28 GGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAG 87
G +AG + PLD +K MQ+ +KT L S++ G+R ++ G
Sbjct: 192 GAVAGAVSRTGTAPLDRLKVFMQV--HASKTNRLNI-LGGLRSMVLEGGIRSLWRGNGIN 248
Query: 88 LLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRM 147
+L+ A + + Y + + G T + V G AGAT + P EV R+
Sbjct: 249 VLKIAPESAIKFMAYEQIKRAILGQQETLH-VQERFVAGSLAGATAQTIIYPMEVLKTRL 307
Query: 148 TADGRLPADQRRG-YKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSK 206
T +R G YK + + RI EG +RG +P + + LA Y K
Sbjct: 308 TL-------RRTGQYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETLK 360
Query: 207 QFLLDSGYFSDN----ILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEYKNG 262
+ L Y D+ IL IS AS P+ + +TR+Q I+G P+ +
Sbjct: 361 NWWLQQ-YSHDSADPGILVLLACGTISSTCGQIASYPLALVRTRMQAQASIEGGPQL-SM 418
Query: 263 LDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKA 306
L +L ++ EG L++G P + ++ P ++++ E M +A
Sbjct: 419 LGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMKQA 462
Score = 64.3 bits (155), Expect = 1e-10
Identities = 49/199 (24%), Positives = 78/199 (39%), Gaps = 10/199 (5%)
Query: 14 GKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILK 73
G+ T +F+ G LAG A + P++++K R+ L +T +YK IL+
Sbjct: 272 GQQETLHVQERFVAGSLAGATAQTIIYPMEVLKTRLTL----RRTGQYKGLLDCARRILE 327
Query: 74 AEGLRGIYTGLSAGLLRQATYTTTRLGIYTVL---FERLTGADGTPPGFLLKAVIGMTAG 130
EG R Y G +L Y L +Y L + + D PG L+ G +
Sbjct: 328 REGPRAFYRGYLPNVLGIIPYAGIDLAVYETLKNWWLQQYSHDSADPGILVLLACGTISS 387
Query: 131 ATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMAR 190
G P + RM A + + ++ L I +EG+ L+RG P +
Sbjct: 388 TCGQIASYPLALVRTRMQAQASIEGGPQ---LSMLGLLRHILSQEGMRGLYRGIAPNFMK 444
Query: 191 AVVVNAAQLASYSQSKQFL 209
+ + Y KQ L
Sbjct: 445 VIPAVSISYVVYENMKQAL 463
>gi|239755176 PREDICTED: similar to solute carrier family 25, member
25 isoform 2 [Homo sapiens]
Length = 469
Score = 77.8 bits (190), Expect = 1e-14
Identities = 76/286 (26%), Positives = 121/286 (42%), Gaps = 28/286 (9%)
Query: 28 GGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAG 87
GG AG + PLD +K MQ+ + F T +++ G R ++ G
Sbjct: 193 GGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGF---TQMIREGGARSLWRGNGIN 249
Query: 88 LLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRM 147
+L+ A + + Y + +RL G+D + V G AGA P EV RM
Sbjct: 250 VLKIAPESAIKFMAYEQI-KRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 308
Query: 148 TADGRLPADQRRG-YKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSK 206
A ++ G Y + + RI EGV ++G +P M + LA Y K
Sbjct: 309 -------ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLK 361
Query: 207 QFLL--------DSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPE 258
L D G F + C +M S AS P+ + +TR+Q I+G PE
Sbjct: 362 NAWLQHYAVNSADPGVF----VLLACGTM-SSTCGQLASYPLALVRTRMQAQASIEGAPE 416
Query: 259 YKNGLDVLFK-VVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQM 303
+ LFK ++R EG F L++G P + ++ P ++++ E +
Sbjct: 417 VT--MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 460
Score = 53.1 bits (126), Expect = 3e-07
Identities = 43/186 (23%), Positives = 67/186 (36%), Gaps = 10/186 (5%)
Query: 24 KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTG 83
+ + G LAG A + P++++K RM L KT +Y IL EG+ Y G
Sbjct: 283 RLVAGSLAGAIAQSSIYPMEVLKTRMAL----RKTGQYSGMLDCARRILAREGVAAFYKG 338
Query: 84 LSAGLLRQATYTTTRLGIYTVL---FERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPA 140
+L Y L +Y L + + + PG + G + G P
Sbjct: 339 YVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPL 398
Query: 141 EVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLA 200
+ RM A + ++F I R EG L+RG P + + +
Sbjct: 399 ALVRTRMQAQASIEGAPEVTMSSLFK---HILRTEGAFGLYRGLAPNFMKVIPAVSISYV 455
Query: 201 SYSQSK 206
Y K
Sbjct: 456 VYENLK 461
Score = 28.5 bits (62), Expect = 8.1
Identities = 21/91 (23%), Positives = 39/91 (42%), Gaps = 17/91 (18%)
Query: 222 HFCASMISGLVTTAASMPVDIAKTRIQ-------NMRMIDGKPEYKNGLDVLFKVVRYEG 274
H A +G V+ + P+D K +Q NM ++ G +++R G
Sbjct: 189 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGG----------FTQMIREGG 238
Query: 275 FFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
SLW+G ++ P + + F+ EQ+ +
Sbjct: 239 ARSLWRGNGINVLKIAPESAIKFMAYEQIKR 269
>gi|239755174 PREDICTED: similar to solute carrier family 25, member
25 isoform 1 [Homo sapiens]
Length = 503
Score = 77.8 bits (190), Expect = 1e-14
Identities = 76/286 (26%), Positives = 121/286 (42%), Gaps = 28/286 (9%)
Query: 28 GGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAG 87
GG AG + PLD +K MQ+ + F T +++ G R ++ G
Sbjct: 227 GGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGF---TQMIREGGARSLWRGNGIN 283
Query: 88 LLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRM 147
+L+ A + + Y + +RL G+D + V G AGA P EV RM
Sbjct: 284 VLKIAPESAIKFMAYEQI-KRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 342
Query: 148 TADGRLPADQRRG-YKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSK 206
A ++ G Y + + RI EGV ++G +P M + LA Y K
Sbjct: 343 -------ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLK 395
Query: 207 QFLL--------DSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPE 258
L D G F + C +M S AS P+ + +TR+Q I+G PE
Sbjct: 396 NAWLQHYAVNSADPGVF----VLLACGTM-SSTCGQLASYPLALVRTRMQAQASIEGAPE 450
Query: 259 YKNGLDVLFK-VVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQM 303
+ LFK ++R EG F L++G P + ++ P ++++ E +
Sbjct: 451 VT--MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 494
Score = 53.1 bits (126), Expect = 3e-07
Identities = 43/186 (23%), Positives = 67/186 (36%), Gaps = 10/186 (5%)
Query: 24 KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTG 83
+ + G LAG A + P++++K RM L KT +Y IL EG+ Y G
Sbjct: 317 RLVAGSLAGAIAQSSIYPMEVLKTRMAL----RKTGQYSGMLDCARRILAREGVAAFYKG 372
Query: 84 LSAGLLRQATYTTTRLGIYTVL---FERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPA 140
+L Y L +Y L + + + PG + G + G P
Sbjct: 373 YVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPL 432
Query: 141 EVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLA 200
+ RM A + ++F I R EG L+RG P + + +
Sbjct: 433 ALVRTRMQAQASIEGAPEVTMSSLFK---HILRTEGAFGLYRGLAPNFMKVIPAVSISYV 489
Query: 201 SYSQSK 206
Y K
Sbjct: 490 VYENLK 495
Score = 28.5 bits (62), Expect = 8.1
Identities = 21/91 (23%), Positives = 39/91 (42%), Gaps = 17/91 (18%)
Query: 222 HFCASMISGLVTTAASMPVDIAKTRIQ-------NMRMIDGKPEYKNGLDVLFKVVRYEG 274
H A +G V+ + P+D K +Q NM ++ G +++R G
Sbjct: 223 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGG----------FTQMIREGG 272
Query: 275 FFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
SLW+G ++ P + + F+ EQ+ +
Sbjct: 273 ARSLWRGNGINVLKIAPESAIKFMAYEQIKR 303
>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
sapiens]
Length = 489
Score = 77.8 bits (190), Expect = 1e-14
Identities = 76/286 (26%), Positives = 121/286 (42%), Gaps = 28/286 (9%)
Query: 28 GGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAG 87
GG AG + PLD +K MQ+ + F T +++ G R ++ G
Sbjct: 213 GGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGF---TQMIREGGARSLWRGNGIN 269
Query: 88 LLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRM 147
+L+ A + + Y + +RL G+D + V G AGA P EV RM
Sbjct: 270 VLKIAPESAIKFMAYEQI-KRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 328
Query: 148 TADGRLPADQRRG-YKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSK 206
A ++ G Y + + RI EGV ++G +P M + LA Y K
Sbjct: 329 -------ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLK 381
Query: 207 QFLL--------DSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPE 258
L D G F + C +M S AS P+ + +TR+Q I+G PE
Sbjct: 382 NAWLQHYAVNSADPGVF----VLLACGTM-SSTCGQLASYPLALVRTRMQAQASIEGAPE 436
Query: 259 YKNGLDVLFK-VVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQM 303
+ LFK ++R EG F L++G P + ++ P ++++ E +
Sbjct: 437 VT--MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 480
Score = 53.1 bits (126), Expect = 3e-07
Identities = 43/186 (23%), Positives = 67/186 (36%), Gaps = 10/186 (5%)
Query: 24 KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTG 83
+ + G LAG A + P++++K RM L KT +Y IL EG+ Y G
Sbjct: 303 RLVAGSLAGAIAQSSIYPMEVLKTRMAL----RKTGQYSGMLDCARRILAREGVAAFYKG 358
Query: 84 LSAGLLRQATYTTTRLGIYTVL---FERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPA 140
+L Y L +Y L + + + PG + G + G P
Sbjct: 359 YVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPL 418
Query: 141 EVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLA 200
+ RM A + ++F I R EG L+RG P + + +
Sbjct: 419 ALVRTRMQAQASIEGAPEVTMSSLFK---HILRTEGAFGLYRGLAPNFMKVIPAVSISYV 475
Query: 201 SYSQSK 206
Y K
Sbjct: 476 VYENLK 481
Score = 28.5 bits (62), Expect = 8.1
Identities = 21/91 (23%), Positives = 39/91 (42%), Gaps = 17/91 (18%)
Query: 222 HFCASMISGLVTTAASMPVDIAKTRIQ-------NMRMIDGKPEYKNGLDVLFKVVRYEG 274
H A +G V+ + P+D K +Q NM ++ G +++R G
Sbjct: 209 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGG----------FTQMIREGG 258
Query: 275 FFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
SLW+G ++ P + + F+ EQ+ +
Sbjct: 259 ARSLWRGNGINVLKIAPESAIKFMAYEQIKR 289
>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
sapiens]
Length = 469
Score = 77.8 bits (190), Expect = 1e-14
Identities = 76/286 (26%), Positives = 121/286 (42%), Gaps = 28/286 (9%)
Query: 28 GGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAG 87
GG AG + PLD +K MQ+ + F T +++ G R ++ G
Sbjct: 193 GGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGF---TQMIREGGARSLWRGNGIN 249
Query: 88 LLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRM 147
+L+ A + + Y + +RL G+D + V G AGA P EV RM
Sbjct: 250 VLKIAPESAIKFMAYEQI-KRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 308
Query: 148 TADGRLPADQRRG-YKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSK 206
A ++ G Y + + RI EGV ++G +P M + LA Y K
Sbjct: 309 -------ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLK 361
Query: 207 QFLL--------DSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPE 258
L D G F + C +M S AS P+ + +TR+Q I+G PE
Sbjct: 362 NAWLQHYAVNSADPGVF----VLLACGTM-SSTCGQLASYPLALVRTRMQAQASIEGAPE 416
Query: 259 YKNGLDVLFK-VVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQM 303
+ LFK ++R EG F L++G P + ++ P ++++ E +
Sbjct: 417 VT--MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 460
Score = 53.1 bits (126), Expect = 3e-07
Identities = 43/186 (23%), Positives = 67/186 (36%), Gaps = 10/186 (5%)
Query: 24 KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTG 83
+ + G LAG A + P++++K RM L KT +Y IL EG+ Y G
Sbjct: 283 RLVAGSLAGAIAQSSIYPMEVLKTRMAL----RKTGQYSGMLDCARRILAREGVAAFYKG 338
Query: 84 LSAGLLRQATYTTTRLGIYTVL---FERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPA 140
+L Y L +Y L + + + PG + G + G P
Sbjct: 339 YVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPL 398
Query: 141 EVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLA 200
+ RM A + ++F I R EG L+RG P + + +
Sbjct: 399 ALVRTRMQAQASIEGAPEVTMSSLFK---HILRTEGAFGLYRGLAPNFMKVIPAVSISYV 455
Query: 201 SYSQSK 206
Y K
Sbjct: 456 VYENLK 461
Score = 28.5 bits (62), Expect = 8.1
Identities = 21/91 (23%), Positives = 39/91 (42%), Gaps = 17/91 (18%)
Query: 222 HFCASMISGLVTTAASMPVDIAKTRIQ-------NMRMIDGKPEYKNGLDVLFKVVRYEG 274
H A +G V+ + P+D K +Q NM ++ G +++R G
Sbjct: 189 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGG----------FTQMIREGG 238
Query: 275 FFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
SLW+G ++ P + + F+ EQ+ +
Sbjct: 239 ARSLWRGNGINVLKIAPESAIKFMAYEQIKR 269
>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
sapiens]
Length = 366
Score = 77.8 bits (190), Expect = 1e-14
Identities = 76/286 (26%), Positives = 121/286 (42%), Gaps = 28/286 (9%)
Query: 28 GGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAG 87
GG AG + PLD +K MQ+ + F T +++ G R ++ G
Sbjct: 90 GGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGF---TQMIREGGARSLWRGNGIN 146
Query: 88 LLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRM 147
+L+ A + + Y + +RL G+D + V G AGA P EV RM
Sbjct: 147 VLKIAPESAIKFMAYEQI-KRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 205
Query: 148 TADGRLPADQRRG-YKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSK 206
A ++ G Y + + RI EGV ++G +P M + LA Y K
Sbjct: 206 -------ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLK 258
Query: 207 QFLL--------DSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPE 258
L D G F + C +M S AS P+ + +TR+Q I+G PE
Sbjct: 259 NAWLQHYAVNSADPGVF----VLLACGTM-SSTCGQLASYPLALVRTRMQAQASIEGAPE 313
Query: 259 YKNGLDVLFK-VVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQM 303
+ LFK ++R EG F L++G P + ++ P ++++ E +
Sbjct: 314 VT--MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 357
Score = 53.1 bits (126), Expect = 3e-07
Identities = 43/186 (23%), Positives = 67/186 (36%), Gaps = 10/186 (5%)
Query: 24 KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTG 83
+ + G LAG A + P++++K RM L KT +Y IL EG+ Y G
Sbjct: 180 RLVAGSLAGAIAQSSIYPMEVLKTRMAL----RKTGQYSGMLDCARRILAREGVAAFYKG 235
Query: 84 LSAGLLRQATYTTTRLGIYTVL---FERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPA 140
+L Y L +Y L + + + PG + G + G P
Sbjct: 236 YVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPL 295
Query: 141 EVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLA 200
+ RM A + ++F I R EG L+RG P + + +
Sbjct: 296 ALVRTRMQAQASIEGAPEVTMSSLFK---HILRTEGAFGLYRGLAPNFMKVIPAVSISYV 352
Query: 201 SYSQSK 206
Y K
Sbjct: 353 VYENLK 358
Score = 28.5 bits (62), Expect = 8.1
Identities = 21/91 (23%), Positives = 39/91 (42%), Gaps = 17/91 (18%)
Query: 222 HFCASMISGLVTTAASMPVDIAKTRIQ-------NMRMIDGKPEYKNGLDVLFKVVRYEG 274
H A +G V+ + P+D K +Q NM ++ G +++R G
Sbjct: 86 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGG----------FTQMIREGG 135
Query: 275 FFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
SLW+G ++ P + + F+ EQ+ +
Sbjct: 136 ARSLWRGNGINVLKIAPESAIKFMAYEQIKR 166
>gi|56699403 solute carrier family 25, member 25 isoform b [Homo
sapiens]
Length = 503
Score = 77.8 bits (190), Expect = 1e-14
Identities = 76/286 (26%), Positives = 121/286 (42%), Gaps = 28/286 (9%)
Query: 28 GGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAG 87
GG AG + PLD +K MQ+ + F T +++ G R ++ G
Sbjct: 227 GGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGF---TQMIREGGARSLWRGNGIN 283
Query: 88 LLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRM 147
+L+ A + + Y + +RL G+D + V G AGA P EV RM
Sbjct: 284 VLKIAPESAIKFMAYEQI-KRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 342
Query: 148 TADGRLPADQRRG-YKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSK 206
A ++ G Y + + RI EGV ++G +P M + LA Y K
Sbjct: 343 -------ALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLK 395
Query: 207 QFLL--------DSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPE 258
L D G F + C +M S AS P+ + +TR+Q I+G PE
Sbjct: 396 NAWLQHYAVNSADPGVF----VLLACGTM-SSTCGQLASYPLALVRTRMQAQASIEGAPE 450
Query: 259 YKNGLDVLFK-VVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQM 303
+ LFK ++R EG F L++G P + ++ P ++++ E +
Sbjct: 451 VT--MSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 494
Score = 53.1 bits (126), Expect = 3e-07
Identities = 43/186 (23%), Positives = 67/186 (36%), Gaps = 10/186 (5%)
Query: 24 KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTG 83
+ + G LAG A + P++++K RM L KT +Y IL EG+ Y G
Sbjct: 317 RLVAGSLAGAIAQSSIYPMEVLKTRMAL----RKTGQYSGMLDCARRILAREGVAAFYKG 372
Query: 84 LSAGLLRQATYTTTRLGIYTVL---FERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPA 140
+L Y L +Y L + + + PG + G + G P
Sbjct: 373 YVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPL 432
Query: 141 EVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLA 200
+ RM A + ++F I R EG L+RG P + + +
Sbjct: 433 ALVRTRMQAQASIEGAPEVTMSSLFK---HILRTEGAFGLYRGLAPNFMKVIPAVSISYV 489
Query: 201 SYSQSK 206
Y K
Sbjct: 490 VYENLK 495
Score = 28.5 bits (62), Expect = 8.1
Identities = 21/91 (23%), Positives = 39/91 (42%), Gaps = 17/91 (18%)
Query: 222 HFCASMISGLVTTAASMPVDIAKTRIQ-------NMRMIDGKPEYKNGLDVLFKVVRYEG 274
H A +G V+ + P+D K +Q NM ++ G +++R G
Sbjct: 223 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGG----------FTQMIREGG 272
Query: 275 FFSLWKGFTPYYARLGPHTVLTFIFLEQMNK 305
SLW+G ++ P + + F+ EQ+ +
Sbjct: 273 ARSLWRGNGINVLKIAPESAIKFMAYEQIKR 303
>gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens]
Length = 323
Score = 77.0 bits (188), Expect = 2e-14
Identities = 67/280 (23%), Positives = 109/280 (38%), Gaps = 25/280 (8%)
Query: 24 KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTG 83
K + GG+AG+ V P+DL K R+Q G R Y + L +++EG G+Y G
Sbjct: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQ--RVYTSMSDCLIKTVRSEGYFGMYRG 68
Query: 84 LSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVA 143
+ L +L F DG L + + G AG V TP E+
Sbjct: 69 AAVNLTLVTPEKAIKLAAND-FFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEML 127
Query: 144 LIRMTADGRLPADQR---------------------RGYKNVFNALIR-ITREEGVLTLW 181
I++ GR+ A ++ + L R + R G+ L+
Sbjct: 128 KIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLY 187
Query: 182 RGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVD 241
+G T+ R V + ++ Q + F A ++G A P D
Sbjct: 188 KGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCD 247
Query: 242 IAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKG 281
+ KTR+Q+++ + Y LD K++R+EG + KG
Sbjct: 248 VVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKG 287
Score = 41.6 bits (96), Expect = 0.001
Identities = 28/75 (37%), Positives = 35/75 (46%), Gaps = 7/75 (9%)
Query: 14 GKPRTSPKS---VKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTS 70
G+P + KS V FL G +AG A V V P D+VK R+Q G Y
Sbjct: 215 GRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARK 274
Query: 71 ILKAEG----LRGIY 81
IL+ EG L+G Y
Sbjct: 275 ILRHEGPSAFLKGAY 289
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,548,264
Number of Sequences: 37866
Number of extensions: 427504
Number of successful extensions: 1403
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 878
Number of HSP's gapped (non-prelim): 179
length of query: 314
length of database: 18,247,518
effective HSP length: 102
effective length of query: 212
effective length of database: 14,385,186
effective search space: 3049659432
effective search space used: 3049659432
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.