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Search of human proteins with 211971038
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens]
(670 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens] 1357 0.0
gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens] 1331 0.0
gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens] 1331 0.0
gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens] 971 0.0
gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens] 970 0.0
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 115 1e-25
gi|150456432 unc-51-like kinase 3 [Homo sapiens] 115 2e-25
gi|93004081 polo-like kinase 2 [Homo sapiens] 113 6e-25
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 111 2e-24
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 111 2e-24
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 110 3e-24
gi|62865643 aurora kinase C isoform 3 [Homo sapiens] 109 7e-24
gi|62865641 aurora kinase C isoform 2 [Homo sapiens] 109 7e-24
gi|62865639 aurora kinase C isoform 1 [Homo sapiens] 109 7e-24
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 108 2e-23
gi|121114283 polo-like kinase 4 [Homo sapiens] 107 3e-23
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 107 5e-23
gi|23308722 TTK protein kinase [Homo sapiens] 106 6e-23
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 105 1e-22
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 105 2e-22
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 105 2e-22
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 104 3e-22
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 104 3e-22
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 104 3e-22
gi|156105707 SNF related kinase [Homo sapiens] 104 3e-22
gi|156105705 SNF related kinase [Homo sapiens] 104 3e-22
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 103 4e-22
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 103 4e-22
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 103 4e-22
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 103 4e-22
>gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens]
Length = 670
Score = 1357 bits (3513), Expect = 0.0
Identities = 670/670 (100%), Positives = 670/670 (100%)
Query: 1 MAVLFLYDLKTTGKTPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGN 60
MAVLFLYDLKTTGKTPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGN
Sbjct: 1 MAVLFLYDLKTTGKTPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGN 60
Query: 61 GSSPVRGIPPAIRSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDL 120
GSSPVRGIPPAIRSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDL
Sbjct: 61 GSSPVRGIPPAIRSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDL 120
Query: 121 TMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKK 180
TMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKK
Sbjct: 121 TMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKK 180
Query: 181 LLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQR 240
LLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQR
Sbjct: 181 LLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQR 240
Query: 241 EDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEY 300
EDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEY
Sbjct: 241 EDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEY 300
Query: 301 HEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERY 360
HEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERY
Sbjct: 301 HEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERY 360
Query: 361 LLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELD 420
LLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELD
Sbjct: 361 LLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELD 420
Query: 421 HPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLN 480
HPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLN
Sbjct: 421 HPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLN 480
Query: 481 EIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWY 540
EIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWY
Sbjct: 481 EIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWY 540
Query: 541 LPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQ 600
LPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQ
Sbjct: 541 LPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQ 600
Query: 601 FPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASP 660
FPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASP
Sbjct: 601 FPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASP 660
Query: 661 TPPSSSIITY 670
TPPSSSIITY
Sbjct: 661 TPPSSSIITY 670
>gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens]
Length = 718
Score = 1331 bits (3444), Expect = 0.0
Identities = 656/657 (99%), Positives = 657/657 (100%)
Query: 14 KTPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR 73
+TPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR
Sbjct: 62 ETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR 121
Query: 74 SPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKI 133
SPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKI
Sbjct: 122 SPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKI 181
Query: 134 QDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS 193
QDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS
Sbjct: 182 QDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS 241
Query: 194 REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKR 253
REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKR
Sbjct: 242 REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKR 301
Query: 254 KPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGH 313
KPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGH
Sbjct: 302 KPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGH 361
Query: 314 LKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSE 373
LKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSE
Sbjct: 362 LKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSE 421
Query: 374 VYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL 433
VYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL
Sbjct: 422 VYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL 481
Query: 434 DTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKP 493
DTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKP
Sbjct: 482 DTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKP 541
Query: 494 GNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPP 553
GNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPP
Sbjct: 542 GNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPP 601
Query: 554 KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA 613
KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA
Sbjct: 602 KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA 661
Query: 614 FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 670
FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY
Sbjct: 662 FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 718
>gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens]
Length = 766
Score = 1331 bits (3444), Expect = 0.0
Identities = 656/657 (99%), Positives = 657/657 (100%)
Query: 14 KTPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR 73
+TPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR
Sbjct: 110 ETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR 169
Query: 74 SPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKI 133
SPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKI
Sbjct: 170 SPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKI 229
Query: 134 QDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS 193
QDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS
Sbjct: 230 QDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS 289
Query: 194 REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKR 253
REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKR
Sbjct: 290 REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKR 349
Query: 254 KPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGH 313
KPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGH
Sbjct: 350 KPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGH 409
Query: 314 LKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSE 373
LKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSE
Sbjct: 410 LKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSE 469
Query: 374 VYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL 433
VYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL
Sbjct: 470 VYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL 529
Query: 434 DTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKP 493
DTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKP
Sbjct: 530 DTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKP 589
Query: 494 GNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPP 553
GNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPP
Sbjct: 590 GNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPP 649
Query: 554 KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA 613
KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA
Sbjct: 650 KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA 709
Query: 614 FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 670
FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY
Sbjct: 710 FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 766
>gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens]
Length = 750
Score = 971 bits (2509), Expect = 0.0
Identities = 514/712 (72%), Positives = 566/712 (79%), Gaps = 76/712 (10%)
Query: 14 KTPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGN--GSSPVRG---- 67
+TPEKKQ++ R RKRKAE E+SQGK RGHKISDYFE+ GG+ G+SP R
Sbjct: 51 ETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFEFAGGSAPGTSPGRSVPPV 107
Query: 68 ------------IPPAIRSPQ-----NSHSHSTPSSSVRP-------------------- 90
+P + P ++ +T S P
Sbjct: 108 ARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQR 167
Query: 91 -------------NSPSPTALAFGDHPIVQPKQLSFKIIQT--DLTMLKLAALESNKIQD 135
NSPS T +H KQ+S + QT DLT+ K++ALE++K D
Sbjct: 168 GAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSD 227
Query: 136 LEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSRE 195
LEKKEGRIDDLLRANCDLRRQIDEQQK+LEKYKERLN+C++MSKKLLIEKS QEK++ R+
Sbjct: 228 LEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRD 287
Query: 196 KSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKP 255
KSMQDRLRLGHFTTVRHGASFTEQWTDG+AFQNL+KQQE +N QRE+IERQRK+LAKRKP
Sbjct: 288 KSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKP 347
Query: 256 PTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLK 315
P QAP +E KQRK+K NGAEN+ LTLAEYHEQEEIFKLRLGHLK
Sbjct: 348 PAMG--QAPPATNEQKQRKSKT-NGAENET---------LTLAEYHEQEEIFKLRLGHLK 395
Query: 316 KEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVY 375
KEEAEIQAELERLERVRNLHIRELKRI+NEDNSQFKDHPTLN+RYLLLHLLGRGGFSEVY
Sbjct: 396 KEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVY 455
Query: 376 KAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDT 435
KAFDL EQRY AVKIHQLNK+WRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDT
Sbjct: 456 KAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDT 515
Query: 436 DTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGN 495
D+FCTVLEYCEGNDLDFYLKQHKLMSEKEARSI+MQIVNAL+YLNEIKPPIIHYDLKPGN
Sbjct: 516 DSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGN 575
Query: 496 ILLVDGTACGEIKITDFGLSKIMDDDSY-GVDGMDLTSQGAGTYWYLPPECFVVGKEPPK 554
ILLV+GTACGEIKITDFGLSKIMDDDSY VDGM+LTSQGAGTYWYLPPECFVVGKEPPK
Sbjct: 576 ILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPK 635
Query: 555 ISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAF 614
ISNKVDVWSVGVIF+QCLYGRKPFGHNQSQQDILQENTILKATEVQFP KPVV+ EAKAF
Sbjct: 636 ISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAF 695
Query: 615 IRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSS 666
IRRCLAYRKEDR DV QLA DPYLLPH+R+S S+ + AG + T +S+
Sbjct: 696 IRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSS--PAGAAIASTSGASN 745
>gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens]
Length = 718
Score = 970 bits (2507), Expect = 0.0
Identities = 507/683 (74%), Positives = 558/683 (81%), Gaps = 50/683 (7%)
Query: 14 KTPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR 73
+TPEKKQ++ R RKRKAE E+SQGK RGHKISDYFE + P+ G+ +
Sbjct: 51 ETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFERRV---EQPLYGLDGSAA 104
Query: 74 SPQNSHSHSTPSS---------------------------SVRPNSPSPTALAFGDHPIV 106
+ P+ S + NSPS T +H
Sbjct: 105 KEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCS 164
Query: 107 QPKQLSFKIIQT--DLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLL 164
KQ+S + QT DLT+ K++ALE++K DLEKKEGRIDDLLRANCDLRRQIDEQQK+L
Sbjct: 165 SQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKML 224
Query: 165 EKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGF 224
EKYKERLN+C++MSKKLLIEKS QEK++ R+KSMQDRLRLGHFTTVRHGASFTEQWTDG+
Sbjct: 225 EKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGY 284
Query: 225 AFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAEND 284
AFQNL+KQQE +N QRE+IERQRK+LAKRKPP QAP +E KQRK+K NGAEN+
Sbjct: 285 AFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG--QAPPATNEQKQRKSKT-NGAENE 341
Query: 285 PFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINN 344
LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRI+N
Sbjct: 342 T---------LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHN 392
Query: 345 EDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKEN 404
EDNSQFKDHPTLN+RYLLLHLLGRGGFSEVYKAFDL EQRY AVKIHQLNK+WRDEKKEN
Sbjct: 393 EDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKEN 452
Query: 405 YHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKE 464
YHKHACREYRIHKELDHPRIVKLYDYFSLDTD+FCTVLEYCEGNDLDFYLKQHKLMSEKE
Sbjct: 453 YHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKE 512
Query: 465 ARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSY- 523
ARSI+MQIVNAL+YLNEIKPPIIHYDLKPGNILLV+GTACGEIKITDFGLSKIMDDDSY
Sbjct: 513 ARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYN 572
Query: 524 GVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQS 583
VDGM+LTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF+QCLYGRKPFGHNQS
Sbjct: 573 SVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQS 632
Query: 584 QQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMR 643
QQDILQENTILKATEVQFP KPVV+ EAKAFIRRCLAYRKEDR DV QLA DPYLLPH+R
Sbjct: 633 QQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIR 692
Query: 644 RSNSSGNLHMAGLTASPTPPSSS 666
+S S+ + AG + T +S+
Sbjct: 693 KSVSTSS--PAGAAIASTSGASN 713
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 115 bits (288), Expect = 1e-25
Identities = 87/279 (31%), Positives = 134/279 (48%), Gaps = 27/279 (9%)
Query: 356 LNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRI 415
L RY L LG+G + +V +A + + R A+K + +K K E H RE I
Sbjct: 51 LKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKI----KDEQDMVHIRREIEI 106
Query: 416 HKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNA 475
L+HP I+ +Y+ F + D ++EY +L Y+ + + +SE+E R QIV+A
Sbjct: 107 MSSLNHPHIISIYEVFE-NKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSA 165
Query: 476 LRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGA 535
+ Y + K ++H DLK NILL D IKI DFGLS + D +
Sbjct: 166 VHYCH--KNGVVHRDLKLENILLDDNC---NIKIADFGLSNLYQKDKF-------LQTFC 213
Query: 536 GTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILK 595
G+ Y PE V G+ P +VD W++GV+ + +YG PF + I Q +
Sbjct: 214 GSPLYASPE-IVNGR--PYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQ----IS 266
Query: 596 ATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLAN 634
+ E + P +P S+A+ IR L + R + +AN
Sbjct: 267 SGEYREPTQP---SDARGLIRWMLMVNPDRRATIEDIAN 302
>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
Length = 472
Score = 115 bits (287), Expect = 2e-25
Identities = 86/299 (28%), Positives = 139/299 (46%), Gaps = 27/299 (9%)
Query: 354 PTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREY 413
P + ++L LG G ++ VYKA+ + R KS EN E
Sbjct: 8 PPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENL----LTEI 63
Query: 414 RIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIV 473
I K + HP IV+L D F D+D ++E+C G DL ++ +++ EK AR + Q+
Sbjct: 64 EILKGIRHPHIVQLKD-FQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLA 122
Query: 474 NALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMD--DDSYGVDGMDLT 531
+AL++L+E I H DLKP NILL +K+ DFG ++ M D+ + + G L
Sbjct: 123 SALQFLHERN--ISHLDLKPQNILL-SSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL- 178
Query: 532 SQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQEN 591
Y+ PE + +VD+WS+GVI ++ L+G+ PF + E
Sbjct: 179 --------YMAPEMVC----QRQYDARVDLWSMGVILYEALFGQPPFASRSFSE---LEE 223
Query: 592 TILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL-LPHMRRSNSSG 649
I ++ P++P++S + + ++R L R P++ L HM S G
Sbjct: 224 KIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLG 282
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 113 bits (282), Expect = 6e-25
Identities = 86/291 (29%), Positives = 139/291 (47%), Gaps = 36/291 (12%)
Query: 354 PTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREY 413
PT +RY +LG+GGF++ Y+ DL + A KI ++ + ++E K E
Sbjct: 76 PTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDK----EI 131
Query: 414 RIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIV 473
+H+ L H +V+ Y YF D + +LEYC + LK K+++E E R + QIV
Sbjct: 132 ELHRILHHKHVVQFYHYFE-DKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIV 190
Query: 474 NALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQ 533
+ L+YL+E I+H DLK GN + + E+K+ DFGL+ ++ + +
Sbjct: 191 SGLKYLHE--QEILHRDLKLGNFFINEAM---ELKVGDFGLAARLEPLEHRRRTI----- 240
Query: 534 GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTI 593
GT YL PE V+ K+ + D+W++G + + L GR PF E T
Sbjct: 241 -CGTPNYLSPE--VLNKQGHGCES--DIWALGCVMYTMLLGRPPF-----------ETTN 284
Query: 594 LKAT-----EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLL 639
LK T E ++ + + + AK I L+ EDR + + + L
Sbjct: 285 LKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFL 335
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 111 bits (277), Expect = 2e-24
Identities = 91/284 (32%), Positives = 137/284 (48%), Gaps = 14/284 (4%)
Query: 356 LNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE-NYHKHACREYR 414
L + Y++ LG G EV AF+ + A+KI K +E + + E
Sbjct: 259 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 318
Query: 415 IHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVN 474
I K+L+HP I+K+ ++F D + + VLE EG +L + +K + E + Q++
Sbjct: 319 ILKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 376
Query: 475 ALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQG 534
A++YL+E IIH DLKP N+LL IKITDFG SKI+ + S L
Sbjct: 377 AVQYLHE--NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS-------LMRTL 427
Query: 535 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTIL 594
GT YL PE +V + VD WS+GVI F CL G PF +++Q + + T
Sbjct: 428 CGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSG 486
Query: 595 KATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 638
K + V VS +A +++ L + RF + P+L
Sbjct: 487 KYNFIP-EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 529
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 111 bits (277), Expect = 2e-24
Identities = 91/284 (32%), Positives = 137/284 (48%), Gaps = 14/284 (4%)
Query: 356 LNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE-NYHKHACREYR 414
L + Y++ LG G EV AF+ + A+KI K +E + + E
Sbjct: 216 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 275
Query: 415 IHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVN 474
I K+L+HP I+K+ ++F D + + VLE EG +L + +K + E + Q++
Sbjct: 276 ILKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 333
Query: 475 ALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQG 534
A++YL+E IIH DLKP N+LL IKITDFG SKI+ + S L
Sbjct: 334 AVQYLHE--NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS-------LMRTL 384
Query: 535 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTIL 594
GT YL PE +V + VD WS+GVI F CL G PF +++Q + + T
Sbjct: 385 CGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSG 443
Query: 595 KATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 638
K + V VS +A +++ L + RF + P+L
Sbjct: 444 KYNFIP-EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 110 bits (276), Expect = 3e-24
Identities = 86/299 (28%), Positives = 145/299 (48%), Gaps = 25/299 (8%)
Query: 341 RINNEDNSQFKDHPT-LNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRD 399
R +D S +K T + + ++ + +LG G FSEV+ + A+K + + ++RD
Sbjct: 3 RKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD 62
Query: 400 EKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKL 459
EN E + K++ H IV L D + T + V++ G +L + + +
Sbjct: 63 SSLEN-------EIAVLKKIKHENIVTLEDIYE-STTHYYLVMQLVSGGELFDRILERGV 114
Query: 460 MSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMD 519
+EK+A ++ Q+++A++YL+E I+H DLKP N+L + +I ITDFGLSK+
Sbjct: 115 YTEKDASLVIQQVLSAVKYLHE--NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQ 172
Query: 520 DDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFG 579
+ + S GT Y+ PE V+ ++P S VD WS+GVI + L G PF
Sbjct: 173 N--------GIMSTACGTPGYVAPE--VLAQKP--YSKAVDCWSIGVITYILLCGYPPF- 219
Query: 580 HNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 638
+ + L E E + P +S AK FI L +R+ + + P++
Sbjct: 220 -YEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
>gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
Length = 275
Score = 109 bits (273), Expect = 7e-24
Identities = 89/282 (31%), Positives = 138/282 (48%), Gaps = 34/282 (12%)
Query: 366 LGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIV 425
LG+G F VY A ++ + V + L KS +KE RE I L HP I+
Sbjct: 15 LGKGKFGNVYLA--RLKESHFIVALKVLFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 70
Query: 426 KLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPP 485
+LY+YF D +LEY +L L++ + + E+ +I+ ++ +AL Y ++ K
Sbjct: 71 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 127
Query: 486 IIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPEC 545
+IH D+KP N+LL GE+KI DFG S + S M GT YLPPE
Sbjct: 128 VIHRDIKPENLLL---GFRGEVKIADFGWS--VHTPSLRRKTM------CGTLDYLPPEM 176
Query: 546 FVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF---GHNQSQQDILQENTILKATEVQFP 602
E KVD+W +GV+ ++ L G PF H+++ + IL+ +V+FP
Sbjct: 177 I----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRFP 225
Query: 603 VKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRR 644
+ + A+ I R L Y+ +R + Q+ P++ H RR
Sbjct: 226 LSMPLG--ARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 265
>gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
Length = 290
Score = 109 bits (273), Expect = 7e-24
Identities = 89/282 (31%), Positives = 138/282 (48%), Gaps = 34/282 (12%)
Query: 366 LGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIV 425
LG+G F VY A ++ + V + L KS +KE RE I L HP I+
Sbjct: 30 LGKGKFGNVYLA--RLKESHFIVALKVLFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 85
Query: 426 KLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPP 485
+LY+YF D +LEY +L L++ + + E+ +I+ ++ +AL Y ++ K
Sbjct: 86 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 142
Query: 486 IIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPEC 545
+IH D+KP N+LL GE+KI DFG S + S M GT YLPPE
Sbjct: 143 VIHRDIKPENLLL---GFRGEVKIADFGWS--VHTPSLRRKTM------CGTLDYLPPEM 191
Query: 546 FVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF---GHNQSQQDILQENTILKATEVQFP 602
E KVD+W +GV+ ++ L G PF H+++ + IL+ +V+FP
Sbjct: 192 I----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRFP 240
Query: 603 VKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRR 644
+ + A+ I R L Y+ +R + Q+ P++ H RR
Sbjct: 241 LSMPLG--ARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 280
>gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
Length = 309
Score = 109 bits (273), Expect = 7e-24
Identities = 89/282 (31%), Positives = 138/282 (48%), Gaps = 34/282 (12%)
Query: 366 LGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIV 425
LG+G F VY A ++ + V + L KS +KE RE I L HP I+
Sbjct: 49 LGKGKFGNVYLA--RLKESHFIVALKVLFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 104
Query: 426 KLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPP 485
+LY+YF D +LEY +L L++ + + E+ +I+ ++ +AL Y ++ K
Sbjct: 105 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 161
Query: 486 IIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPEC 545
+IH D+KP N+LL GE+KI DFG S + S M GT YLPPE
Sbjct: 162 VIHRDIKPENLLL---GFRGEVKIADFGWS--VHTPSLRRKTM------CGTLDYLPPEM 210
Query: 546 FVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF---GHNQSQQDILQENTILKATEVQFP 602
E KVD+W +GV+ ++ L G PF H+++ + IL+ +V+FP
Sbjct: 211 I----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRFP 259
Query: 603 VKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRR 644
+ + A+ I R L Y+ +R + Q+ P++ H RR
Sbjct: 260 LSMPLG--ARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 299
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 108 bits (270), Expect = 2e-23
Identities = 87/295 (29%), Positives = 145/295 (49%), Gaps = 26/295 (8%)
Query: 346 DNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVK-IHQLNKSWRDEKKEN 404
+ ++K + + Y +LG G FSEV A D Q+ A+K I + ++ EN
Sbjct: 6 EGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMEN 65
Query: 405 YHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKE 464
E + ++ HP IV L D + + +++ G +L + + +E++
Sbjct: 66 -------EIAVLHKIKHPNIVALDDIYESGGHLYL-IMQLVSGGELFDRIVEKGFYTERD 117
Query: 465 ARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYG 524
A ++ Q+++A++YL+++ I+H DLKP N+L +I I+DFGLSK+ D S
Sbjct: 118 ASRLIFQVLDAVKYLHDLG--IVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGS-- 173
Query: 525 VDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQ 584
+ S GT Y+ PE V+ ++P S VD WS+GVI + L G PF ++++
Sbjct: 174 -----VLSTACGTPGYVAPE--VLAQKP--YSKAVDCWSIGVIAYILLCGYPPF-YDEND 223
Query: 585 QDILQENTILKAT-EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 638
+ ++ ILKA E P +S AK FIR + E RF Q P++
Sbjct: 224 AKLFEQ--ILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 107 bits (268), Expect = 3e-23
Identities = 86/285 (30%), Positives = 138/285 (48%), Gaps = 33/285 (11%)
Query: 358 ERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHK 417
E + + +LLG+G F+ VY+A ++ A+K+ + K + E +IH
Sbjct: 10 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMY----KAGMVQRVQNEVKIHC 65
Query: 418 ELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQH-KLMSEKEARSIVMQIVNAL 476
+L HP I++LY+YF D++ VLE C +++ YLK K SE EAR + QI+ +
Sbjct: 66 QLKHPSILELYNYFE-DSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGM 124
Query: 477 RYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLS---KIMDDDSYGVDGMDLTSQ 533
YL+ I+H DL N+LL T IKI DFGL+ K+ + Y +
Sbjct: 125 LYLH--SHGILHRDLTLSNLLL---TRNMNIKIADFGLATQLKMPHEKHYTL-------- 171
Query: 534 GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTI 593
GT Y+ PE + + + + DVWS+G +F+ L GR PF + +NT+
Sbjct: 172 -CGTPNYISPE--IATRSAHGLES--DVWSLGCMFYTLLIGRPPFDTD------TVKNTL 220
Query: 594 LKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 638
K + + +S EAK I + L DR + + + P++
Sbjct: 221 NKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM 265
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 107 bits (266), Expect = 5e-23
Identities = 93/283 (32%), Positives = 136/283 (48%), Gaps = 35/283 (12%)
Query: 360 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKI---HQLNKSWRDEKKENYHKHACREYRIH 416
Y LL +G+G F++V A + R A+KI QLN S + RE RI
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQK--------LFREVRIM 110
Query: 417 KELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNAL 476
K L+HP IVKL++ + T V+EY ++ YL H M EKEAR+ QIV+A+
Sbjct: 111 KGLNHPNIVKLFEVIETEK-TLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAV 169
Query: 477 RYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAG 536
Y ++ I+H DLK N+LL A IKI DFG S ++ + G G
Sbjct: 170 HYCHQ--KNIVHRDLKAENLLL---DAEANIKIADFGFS---NEFTLG----SKLDTFCG 217
Query: 537 TYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILK 595
+ Y PE F K +VD+WS+GVI + + G PF GHN + L+E +
Sbjct: 218 SPPYAAPELFQGKKYD---GPEVDIWSLGVILYTLVSGSLPFDGHNLKE---LRERVLRG 271
Query: 596 ATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 638
V F +S++ ++ +RR L R + Q+ D ++
Sbjct: 272 KYRVPF----YMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 310
>gi|23308722 TTK protein kinase [Homo sapiens]
Length = 857
Score = 106 bits (265), Expect = 6e-23
Identities = 84/291 (28%), Positives = 143/291 (49%), Gaps = 36/291 (12%)
Query: 360 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 419
Y +L +G GG S+V++ + +Q YA +K L ++ ++ ++Y ++ +
Sbjct: 525 YSILKQIGSGGSSKVFQVLNEKKQIYA-IKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 582
Query: 420 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 479
D +I++LYDY TD + ++ C DL+ +LK+ K + E +S ++ A+ +
Sbjct: 583 D--KIIRLYDYEI--TDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 638
Query: 480 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 539
++ I+H DLKP N L+VDG +K+ DFG++ M D+ V + GT
Sbjct: 639 HQ--HGIVHSDLKPANFLIVDGM----LKLIDFGIANQMQPDTTSV----VKDSQVGTVN 688
Query: 540 YLPPECFVV-------GKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENT 592
Y+PPE GK KIS K DVWS+G I + YG+ PF Q I+ + +
Sbjct: 689 YMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQIS 742
Query: 593 ILKAT-----EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 638
L A E++FP P + + ++ CL + R + +L PY+
Sbjct: 743 KLHAIIDPNHEIEFPDIP--EKDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 105 bits (263), Expect = 1e-22
Identities = 93/311 (29%), Positives = 145/311 (46%), Gaps = 28/311 (9%)
Query: 358 ERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHK 417
E+Y +L ++G G F VYK Y + A+K + K R EK+ ++ RE I +
Sbjct: 2 EKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKF--IPKLGRSEKE---LRNLQREIEIMR 56
Query: 418 ELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALR 477
L HP IV + D F D + V +Y EG +L L+ + E + ++I Q+V+AL
Sbjct: 57 GLRHPNIVHMLDSFETDKEV-VVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALY 114
Query: 478 YLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGT 537
YL+ + I+H D+KP NILL G G IK+ DFG ++ M ++ M LTS GT
Sbjct: 115 YLHSHR--ILHRDMKPQNILLAKG---GGIKLCDFGFARAMSTNT-----MVLTSI-KGT 163
Query: 538 YWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKAT 597
Y+ PE +V + P + D+WSVG I ++ G PF I Q +++
Sbjct: 164 PLYMSPE--LVEERP--YDHTADLWSVGCILYELAVGTPPF----YATSIFQLVSLILKD 215
Query: 598 EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLT 657
V++P +S K F++ L R L P++ H+ +
Sbjct: 216 PVRWP--STISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPF 273
Query: 658 ASPTPPSSSII 668
S PP ++
Sbjct: 274 TSRLPPELQVL 284
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 105 bits (261), Expect = 2e-22
Identities = 88/279 (31%), Positives = 139/279 (49%), Gaps = 29/279 (10%)
Query: 363 LHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHP 422
L ++G+G F +V A + ++ AVK+ L K +KE H A R + K + HP
Sbjct: 165 LKVIGKGSFGKVLLAKRKLDGKFYAVKV--LQKKIVLNRKEQKHIMAERNVLL-KNVKHP 221
Query: 423 RIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEI 482
+V L+ F T+ VL++ G +L F+L++ + E AR +I +AL YL+ I
Sbjct: 222 FLVGLHYSFQT-TEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
Query: 483 KPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLP 542
K I++ DLKP NILL + G + +TDFGL K G+ D T+ GT YL
Sbjct: 281 K--IVYRDLKPENILL---DSVGHVVLTDFGLCK------EGIAISDTTTTFCGTPEYLA 329
Query: 543 PECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFP 602
PE V+ K+P N VD W +G + ++ LYG PF + + +N + K
Sbjct: 330 PE--VIRKQP--YDNTVDWWCLGAVLYEMLYGLPPFYCRDVAE--MYDNILHK----PLS 379
Query: 603 VKPVVSSEAKAFIRRCLAYRKEDRF----DVHQLANDPY 637
++P VS A + + L +++R D ++ N P+
Sbjct: 380 LRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPF 418
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 105 bits (261), Expect = 2e-22
Identities = 88/279 (31%), Positives = 139/279 (49%), Gaps = 29/279 (10%)
Query: 363 LHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHP 422
L ++G+G F +V A + ++ AVK+ L K +KE H A R + K + HP
Sbjct: 165 LKVIGKGSFGKVLLAKRKLDGKFYAVKV--LQKKIVLNRKEQKHIMAERNVLL-KNVKHP 221
Query: 423 RIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEI 482
+V L+ F T+ VL++ G +L F+L++ + E AR +I +AL YL+ I
Sbjct: 222 FLVGLHYSFQT-TEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
Query: 483 KPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLP 542
K I++ DLKP NILL + G + +TDFGL K G+ D T+ GT YL
Sbjct: 281 K--IVYRDLKPENILL---DSVGHVVLTDFGLCK------EGIAISDTTTTFCGTPEYLA 329
Query: 543 PECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFP 602
PE V+ K+P N VD W +G + ++ LYG PF + + +N + K
Sbjct: 330 PE--VIRKQP--YDNTVDWWCLGAVLYEMLYGLPPFYCRDVAE--MYDNILHK----PLS 379
Query: 603 VKPVVSSEAKAFIRRCLAYRKEDRF----DVHQLANDPY 637
++P VS A + + L +++R D ++ N P+
Sbjct: 380 LRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPF 418
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 104 bits (259), Expect = 3e-22
Identities = 87/295 (29%), Positives = 133/295 (45%), Gaps = 42/295 (14%)
Query: 365 LLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHAC---REYRIHKELDH 421
L+G G F+ V+K + H L + + K+N K +E +I KEL H
Sbjct: 21 LIGHGAFAVVFKGRHREK--------HDLEVAVKCINKKNLAKSQTLLGKEIKILKELKH 72
Query: 422 PRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNE 481
IV LYD+ + + V+EYC G DL YL + +SE R + QI A+R L+
Sbjct: 73 ENIVALYDFQEMANSVYL-VMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLH- 130
Query: 482 IKPPIIHYDLKPGNILLVDGTA------CGEIKITDFGLSKIMDDDSYGVDGMDLTSQGA 535
IIH DLKP NILL + +KI DFG ++ + + + +
Sbjct: 131 -SKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNM-------MAATLC 182
Query: 536 GTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDI---LQENT 592
G+ Y+ PE + K D+WS+G I +QCL G+ PF S QD+ ++N
Sbjct: 183 GSPMYMAPEVIM----SQHYDGKADLWSIGTIVYQCLTGKAPF-QASSPQDLRLFYEKNK 237
Query: 593 ILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL--LPHMRRS 645
L T + S+ + + L +DR D + + P+L P +R+S
Sbjct: 238 TLVPT-----IPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKS 287
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 104 bits (259), Expect = 3e-22
Identities = 113/399 (28%), Positives = 175/399 (43%), Gaps = 40/399 (10%)
Query: 230 VKQQEWVNQQREDIE--RQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAE--NDP 285
+ ++ WV ++ E I+ R R L K + P P N +V +
Sbjct: 6 IVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTE 65
Query: 286 FVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAE-IQAELERLERVRNLHIR-----EL 339
+PN + L E F + ++E E IQA +RL+R + ++
Sbjct: 66 RPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQI 125
Query: 340 KRINNEDNSQFKDH---PTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKS 396
I E+ H T+N+ + L LLG+G F +V + +Y A+KI L K
Sbjct: 126 DNIGEEEMDASTTHHKRKTMND-FDYLKLLGKGTFGKVILVREKASGKYYAMKI--LKKE 182
Query: 397 WRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQ 456
K E H E R+ K HP + L Y D C V+EY G +L F+L +
Sbjct: 183 VIIAKDEV--AHTLTESRVLKNTRHPFLTSL-KYSFQTKDRLCFVMEYVNGGELFFHLSR 239
Query: 457 HKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSK 516
++ SE R +IV+AL YL+ K I++ DLK N++L G IKITDFGL K
Sbjct: 240 ERVFSEDRTRFYGAEIVSALDYLHSGK--IVYRDLKLENLML---DKDGHIKITDFGLCK 294
Query: 517 IMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRK 576
G+ GT YL PE E VD W +GV+ ++ + GR
Sbjct: 295 ------EGITDAATMKTFCGTPEYLAPEVL----EDNDYGRAVDWWGLGVVMYEMMCGRL 344
Query: 577 PFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFI 615
PF +NQ + + + ++ +++FP +SS+AK+ +
Sbjct: 345 PF-YNQDHEKLFE---LILMEDIKFP--RTLSSDAKSLL 377
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 104 bits (259), Expect = 3e-22
Identities = 113/399 (28%), Positives = 175/399 (43%), Gaps = 40/399 (10%)
Query: 230 VKQQEWVNQQREDIE--RQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAE--NDP 285
+ ++ WV ++ E I+ R R L K + P P N +V +
Sbjct: 6 IVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTE 65
Query: 286 FVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAE-IQAELERLERVRNLHIR-----EL 339
+PN + L E F + ++E E IQA +RL+R + ++
Sbjct: 66 RPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQI 125
Query: 340 KRINNEDNSQFKDH---PTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKS 396
I E+ H T+N+ + L LLG+G F +V + +Y A+KI L K
Sbjct: 126 DNIGEEEMDASTTHHKRKTMND-FDYLKLLGKGTFGKVILVREKASGKYYAMKI--LKKE 182
Query: 397 WRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQ 456
K E H E R+ K HP + L Y D C V+EY G +L F+L +
Sbjct: 183 VIIAKDEV--AHTLTESRVLKNTRHPFLTSL-KYSFQTKDRLCFVMEYVNGGELFFHLSR 239
Query: 457 HKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSK 516
++ SE R +IV+AL YL+ K I++ DLK N++L G IKITDFGL K
Sbjct: 240 ERVFSEDRTRFYGAEIVSALDYLHSGK--IVYRDLKLENLML---DKDGHIKITDFGLCK 294
Query: 517 IMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRK 576
G+ GT YL PE E VD W +GV+ ++ + GR
Sbjct: 295 ------EGITDAATMKTFCGTPEYLAPEVL----EDNDYGRAVDWWGLGVVMYEMMCGRL 344
Query: 577 PFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFI 615
PF +NQ + + + ++ +++FP +SS+AK+ +
Sbjct: 345 PF-YNQDHEKLFE---LILMEDIKFP--RTLSSDAKSLL 377
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 104 bits (259), Expect = 3e-22
Identities = 85/280 (30%), Positives = 137/280 (48%), Gaps = 27/280 (9%)
Query: 360 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 419
Y L LGRG F+ V A ++ AVK+ ++K+ D H +E R K +
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKV--IDKTKLDTLATG---HLFQEVRCMKLV 70
Query: 420 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDL-DFYLKQHKLMSEKEARSIVMQIVNALRY 478
HP IV+LY+ T + +LE +G D+ D+ +K + ++E A+ QIV+A+ Y
Sbjct: 71 QHPNIVRLYEVIDTQTKLY-LILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 129
Query: 479 LNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTY 538
+++ ++H DLKP N++ + G +K+TDFG S G LT+ G+
Sbjct: 130 CHKLH--VVHRDLKPENVVFFEKQ--GLVKLTDFGFSNKFQ------PGKKLTT-SCGSL 178
Query: 539 WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE 598
Y PE ++G E + VD+WS+GVI F + G+ PF Q+ T+ +
Sbjct: 179 AYSAPE-ILLGDEYD--APAVDIWSLGVILFMLVCGQPPF------QEANDSETLTMIMD 229
Query: 599 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 638
++ V VS E K I R L + R + ++ N P+L
Sbjct: 230 CKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWL 269
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 104 bits (259), Expect = 3e-22
Identities = 85/280 (30%), Positives = 137/280 (48%), Gaps = 27/280 (9%)
Query: 360 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 419
Y L LGRG F+ V A ++ AVK+ ++K+ D H +E R K +
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKV--IDKTKLDTLATG---HLFQEVRCMKLV 70
Query: 420 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDL-DFYLKQHKLMSEKEARSIVMQIVNALRY 478
HP IV+LY+ T + +LE +G D+ D+ +K + ++E A+ QIV+A+ Y
Sbjct: 71 QHPNIVRLYEVIDTQTKLY-LILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 129
Query: 479 LNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTY 538
+++ ++H DLKP N++ + G +K+TDFG S G LT+ G+
Sbjct: 130 CHKLH--VVHRDLKPENVVFFEKQ--GLVKLTDFGFSNKFQ------PGKKLTT-SCGSL 178
Query: 539 WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE 598
Y PE ++G E + VD+WS+GVI F + G+ PF Q+ T+ +
Sbjct: 179 AYSAPE-ILLGDEYD--APAVDIWSLGVILFMLVCGQPPF------QEANDSETLTMIMD 229
Query: 599 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 638
++ V VS E K I R L + R + ++ N P+L
Sbjct: 230 CKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWL 269
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 103 bits (258), Expect = 4e-22
Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 29/280 (10%)
Query: 360 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 419
Y LL +G+G F++V A + R A+KI + + + RE RI K L
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPTSLQKLFREVRIMKIL 110
Query: 420 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 479
+HP IVKL++ + T ++EY G ++ YL H M EKEARS QIV+A++Y
Sbjct: 111 NHPNIVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169
Query: 480 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 539
++ + I+H DLK N+LL A IKI DFG S + + V G T G+
Sbjct: 170 HQKR--IVHRDLKAENLLL---DADMNIKIADFGFS-----NEFTVGGKLDTFCGSPP-- 217
Query: 540 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILKATE 598
Y PE F K +VDVWS+GVI + + G PF G N + L+E +
Sbjct: 218 YAAPELFQGKKYD---GPEVDVWSLGVILYTLVSGSLPFDGQNLKE---LRERVLRGKYR 271
Query: 599 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 638
+ F +S++ + ++R L R + Q+ D ++
Sbjct: 272 IPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 103 bits (258), Expect = 4e-22
Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 29/280 (10%)
Query: 360 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 419
Y LL +G+G F++V A + R A+KI + + + RE RI K L
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPTSLQKLFREVRIMKIL 110
Query: 420 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 479
+HP IVKL++ + T ++EY G ++ YL H M EKEARS QIV+A++Y
Sbjct: 111 NHPNIVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169
Query: 480 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 539
++ + I+H DLK N+LL A IKI DFG S + + V G T G+
Sbjct: 170 HQKR--IVHRDLKAENLLL---DADMNIKIADFGFS-----NEFTVGGKLDTFCGSPP-- 217
Query: 540 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILKATE 598
Y PE F K +VDVWS+GVI + + G PF G N + L+E +
Sbjct: 218 YAAPELFQGKKYD---GPEVDVWSLGVILYTLVSGSLPFDGQNLKE---LRERVLRGKYR 271
Query: 599 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 638
+ F +S++ + ++R L R + Q+ D ++
Sbjct: 272 IPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 103 bits (258), Expect = 4e-22
Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 29/280 (10%)
Query: 360 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 419
Y LL +G+G F++V A + R A+KI + + + RE RI K L
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPTSLQKLFREVRIMKIL 110
Query: 420 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 479
+HP IVKL++ + T ++EY G ++ YL H M EKEARS QIV+A++Y
Sbjct: 111 NHPNIVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169
Query: 480 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 539
++ + I+H DLK N+LL A IKI DFG S + + V G T G+
Sbjct: 170 HQKR--IVHRDLKAENLLL---DADMNIKIADFGFS-----NEFTVGGKLDTFCGSPP-- 217
Query: 540 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILKATE 598
Y PE F K +VDVWS+GVI + + G PF G N + L+E +
Sbjct: 218 YAAPELFQGKKYD---GPEVDVWSLGVILYTLVSGSLPFDGQNLKE---LRERVLRGKYR 271
Query: 599 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 638
+ F +S++ + ++R L R + Q+ D ++
Sbjct: 272 IPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 103 bits (258), Expect = 4e-22
Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 29/280 (10%)
Query: 360 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 419
Y LL +G+G F++V A + R A+KI + + + RE RI K L
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPTSLQKLFREVRIMKIL 110
Query: 420 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 479
+HP IVKL++ + T ++EY G ++ YL H M EKEARS QIV+A++Y
Sbjct: 111 NHPNIVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169
Query: 480 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 539
++ + I+H DLK N+LL A IKI DFG S + + V G T G+
Sbjct: 170 HQKR--IVHRDLKAENLLL---DADMNIKIADFGFS-----NEFTVGGKLDTFCGSPP-- 217
Query: 540 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILKATE 598
Y PE F K +VDVWS+GVI + + G PF G N + L+E +
Sbjct: 218 YAAPELFQGKKYD---GPEVDVWSLGVILYTLVSGSLPFDGQNLKE---LRERVLRGKYR 271
Query: 599 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 638
+ F +S++ + ++R L R + Q+ D ++
Sbjct: 272 IPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,144,571
Number of Sequences: 37866
Number of extensions: 1303438
Number of successful extensions: 9870
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 240
Number of HSP's successfully gapped in prelim test: 821
Number of HSP's that attempted gapping in prelim test: 7347
Number of HSP's gapped (non-prelim): 2065
length of query: 670
length of database: 18,247,518
effective HSP length: 109
effective length of query: 561
effective length of database: 14,120,124
effective search space: 7921389564
effective search space used: 7921389564
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.