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Search of human proteins with 211971036
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens]
(718 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens] 1450 0.0
gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens] 1450 0.0
gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens] 1331 0.0
gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens] 1030 0.0
gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens] 1030 0.0
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 115 1e-25
gi|150456432 unc-51-like kinase 3 [Homo sapiens] 115 2e-25
gi|93004081 polo-like kinase 2 [Homo sapiens] 113 7e-25
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 111 3e-24
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 111 3e-24
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 110 3e-24
gi|62865643 aurora kinase C isoform 3 [Homo sapiens] 109 8e-24
gi|62865641 aurora kinase C isoform 2 [Homo sapiens] 109 8e-24
gi|62865639 aurora kinase C isoform 1 [Homo sapiens] 109 8e-24
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 108 2e-23
gi|121114283 polo-like kinase 4 [Homo sapiens] 107 3e-23
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 107 5e-23
gi|23308722 TTK protein kinase [Homo sapiens] 106 7e-23
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 105 1e-22
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 105 2e-22
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 105 2e-22
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 104 3e-22
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 104 3e-22
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 104 3e-22
gi|156105707 SNF related kinase [Homo sapiens] 104 3e-22
gi|156105705 SNF related kinase [Homo sapiens] 104 3e-22
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 103 4e-22
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 103 4e-22
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 103 4e-22
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 103 4e-22
>gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens]
Length = 718
Score = 1450 bits (3754), Expect = 0.0
Identities = 718/718 (100%), Positives = 718/718 (100%)
Query: 1 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 60
MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE
Sbjct: 1 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 60
Query: 61 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 120
SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI
Sbjct: 61 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 120
Query: 121 RSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNK 180
RSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNK
Sbjct: 121 RSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNK 180
Query: 181 IQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLS 240
IQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLS
Sbjct: 181 IQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLS 240
Query: 241 SREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAK 300
SREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAK
Sbjct: 241 SREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAK 300
Query: 301 RKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLG 360
RKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLG
Sbjct: 301 RKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLG 360
Query: 361 HLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFS 420
HLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFS
Sbjct: 361 HLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFS 420
Query: 421 EVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS 480
EVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS
Sbjct: 421 EVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS 480
Query: 481 LDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLK 540
LDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLK
Sbjct: 481 LDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLK 540
Query: 541 PGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEP 600
PGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEP
Sbjct: 541 PGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEP 600
Query: 601 PKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAK 660
PKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAK
Sbjct: 601 PKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAK 660
Query: 661 AFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 718
AFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY
Sbjct: 661 AFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 718
>gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens]
Length = 766
Score = 1450 bits (3754), Expect = 0.0
Identities = 718/718 (100%), Positives = 718/718 (100%)
Query: 1 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 60
MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE
Sbjct: 49 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 108
Query: 61 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 120
SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI
Sbjct: 109 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 168
Query: 121 RSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNK 180
RSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNK
Sbjct: 169 RSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNK 228
Query: 181 IQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLS 240
IQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLS
Sbjct: 229 IQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLS 288
Query: 241 SREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAK 300
SREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAK
Sbjct: 289 SREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAK 348
Query: 301 RKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLG 360
RKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLG
Sbjct: 349 RKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLG 408
Query: 361 HLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFS 420
HLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFS
Sbjct: 409 HLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFS 468
Query: 421 EVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS 480
EVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS
Sbjct: 469 EVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFS 528
Query: 481 LDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLK 540
LDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLK
Sbjct: 529 LDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLK 588
Query: 541 PGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEP 600
PGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEP
Sbjct: 589 PGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEP 648
Query: 601 PKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAK 660
PKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAK
Sbjct: 649 PKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAK 708
Query: 661 AFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 718
AFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY
Sbjct: 709 AFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 766
>gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens]
Length = 670
Score = 1331 bits (3444), Expect = 0.0
Identities = 656/657 (99%), Positives = 657/657 (100%)
Query: 62 ETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR 121
+TPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR
Sbjct: 14 KTPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIR 73
Query: 122 SPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKI 181
SPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKI
Sbjct: 74 SPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKI 133
Query: 182 QDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS 241
QDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS
Sbjct: 134 QDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS 193
Query: 242 REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKR 301
REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKR
Sbjct: 194 REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKR 253
Query: 302 KPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGH 361
KPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGH
Sbjct: 254 KPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGH 313
Query: 362 LKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSE 421
LKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSE
Sbjct: 314 LKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSE 373
Query: 422 VYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL 481
VYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL
Sbjct: 374 VYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL 433
Query: 482 DTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKP 541
DTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKP
Sbjct: 434 DTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKP 493
Query: 542 GNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPP 601
GNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPP
Sbjct: 494 GNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPP 553
Query: 602 KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA 661
KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA
Sbjct: 554 KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA 613
Query: 662 FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 718
FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY
Sbjct: 614 FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 670
>gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens]
Length = 750
Score = 1030 bits (2664), Expect = 0.0
Identities = 551/773 (71%), Positives = 606/773 (78%), Gaps = 88/773 (11%)
Query: 1 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 60
M+ELHSLDPRRQELLEARFTGV +K N+ESSN S S+GSLSDKE
Sbjct: 2 MEELHSLDPRRQELLEARFTGVGV------------SKGPLNSESSNQSLCSVGSLSDKE 49
Query: 61 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGN--GSSPVRG--- 115
ETPEKKQ++ R RKRKAE E+SQGK RGHKISDYFE+ GG+ G+SP R
Sbjct: 50 VETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFEFAGGSAPGTSPGRSVPP 106
Query: 116 -------------IPPAIRSPQ-----NSHSHSTPSSSVRP------------------- 138
+P + P ++ +T S P
Sbjct: 107 VARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQ 166
Query: 139 --------------NSPSPTALAFGDHPIVQPKQLSFKIIQT--DLTMLKLAALESNKIQ 182
NSPS T +H KQ+S + QT DLT+ K++ALE++K
Sbjct: 167 RGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNS 226
Query: 183 DLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSR 242
DLEKKEGRIDDLLRANCDLRRQIDEQQK+LEKYKERLN+C++MSKKLLIEKS QEK++ R
Sbjct: 227 DLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACR 286
Query: 243 EKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRK 302
+KSMQDRLRLGHFTTVRHGASFTEQWTDG+AFQNL+KQQE +N QRE+IERQRK+LAKRK
Sbjct: 287 DKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRK 346
Query: 303 PPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHL 362
PP QAP +E KQRK+K NGAEN+ LTLAEYHEQEEIFKLRLGHL
Sbjct: 347 PPAMG--QAPPATNEQKQRKSKT-NGAENET---------LTLAEYHEQEEIFKLRLGHL 394
Query: 363 KKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEV 422
KKEEAEIQAELERLERVRNLHIRELKRI+NEDNSQFKDHPTLN+RYLLLHLLGRGGFSEV
Sbjct: 395 KKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEV 454
Query: 423 YKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD 482
YKAFDL EQRY AVKIHQLNK+WRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD
Sbjct: 455 YKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD 514
Query: 483 TDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPG 542
TD+FCTVLEYCEGNDLDFYLKQHKLMSEKEARSI+MQIVNAL+YLNEIKPPIIHYDLKPG
Sbjct: 515 TDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPG 574
Query: 543 NILLVDGTACGEIKITDFGLSKIMDDDSY-GVDGMDLTSQGAGTYWYLPPECFVVGKEPP 601
NILLV+GTACGEIKITDFGLSKIMDDDSY VDGM+LTSQGAGTYWYLPPECFVVGKEPP
Sbjct: 575 NILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPP 634
Query: 602 KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKA 661
KISNKVDVWSVGVIF+QCLYGRKPFGHNQSQQDILQENTILKATEVQFP KPVV+ EAKA
Sbjct: 635 KISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKA 694
Query: 662 FIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSS 714
FIRRCLAYRKEDR DV QLA DPYLLPH+R+S S+ + AG + T +S+
Sbjct: 695 FIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSS--PAGAAIASTSGASN 745
>gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens]
Length = 718
Score = 1030 bits (2662), Expect = 0.0
Identities = 544/744 (73%), Positives = 598/744 (80%), Gaps = 62/744 (8%)
Query: 1 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKE 60
M+ELHSLDPRRQELLEARFTGV +K N+ESSN S S+GSLSDKE
Sbjct: 2 MEELHSLDPRRQELLEARFTGVGV------------SKGPLNSESSNQSLCSVGSLSDKE 49
Query: 61 SETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAI 120
ETPEKKQ++ R RKRKAE E+SQGK RGHKISDYFE + P+ G+ +
Sbjct: 50 VETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFERRV---EQPLYGLDGSA 103
Query: 121 RSPQNSHSHSTPSS---------------------------SVRPNSPSPTALAFGDHPI 153
+ P+ S + NSPS T +H
Sbjct: 104 AKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSC 163
Query: 154 VQPKQLSFKIIQT--DLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKL 211
KQ+S + QT DLT+ K++ALE++K DLEKKEGRIDDLLRANCDLRRQIDEQQK+
Sbjct: 164 SSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKM 223
Query: 212 LEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDG 271
LEKYKERLN+C++MSKKLLIEKS QEK++ R+KSMQDRLRLGHFTTVRHGASFTEQWTDG
Sbjct: 224 LEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDG 283
Query: 272 FAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAEN 331
+AFQNL+KQQE +N QRE+IERQRK+LAKRKPP QAP +E KQRK+K NGAEN
Sbjct: 284 YAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG--QAPPATNEQKQRKSKT-NGAEN 340
Query: 332 DPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIN 391
+ LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRI+
Sbjct: 341 ET---------LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIH 391
Query: 392 NEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE 451
NEDNSQFKDHPTLN+RYLLLHLLGRGGFSEVYKAFDL EQRY AVKIHQLNK+WRDEKKE
Sbjct: 392 NEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKE 451
Query: 452 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEK 511
NYHKHACREYRIHKELDHPRIVKLYDYFSLDTD+FCTVLEYCEGNDLDFYLKQHKLMSEK
Sbjct: 452 NYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEK 511
Query: 512 EARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSY 571
EARSI+MQIVNAL+YLNEIKPPIIHYDLKPGNILLV+GTACGEIKITDFGLSKIMDDDSY
Sbjct: 512 EARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSY 571
Query: 572 -GVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQ 630
VDGM+LTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF+QCLYGRKPFGHNQ
Sbjct: 572 NSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQ 631
Query: 631 SQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHM 690
SQQDILQENTILKATEVQFP KPVV+ EAKAFIRRCLAYRKEDR DV QLA DPYLLPH+
Sbjct: 632 SQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 691
Query: 691 RRSNSSGNLHMAGLTASPTPPSSS 714
R+S S+ + AG + T +S+
Sbjct: 692 RKSVSTSS--PAGAAIASTSGASN 713
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 115 bits (288), Expect = 1e-25
Identities = 87/279 (31%), Positives = 134/279 (48%), Gaps = 27/279 (9%)
Query: 404 LNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRI 463
L RY L LG+G + +V +A + + R A+K + +K K E H RE I
Sbjct: 51 LKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKI----KDEQDMVHIRREIEI 106
Query: 464 HKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNA 523
L+HP I+ +Y+ F + D ++EY +L Y+ + + +SE+E R QIV+A
Sbjct: 107 MSSLNHPHIISIYEVFE-NKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSA 165
Query: 524 LRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGA 583
+ Y + K ++H DLK NILL D IKI DFGLS + D +
Sbjct: 166 VHYCH--KNGVVHRDLKLENILLDDNC---NIKIADFGLSNLYQKDKF-------LQTFC 213
Query: 584 GTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILK 643
G+ Y PE V G+ P +VD W++GV+ + +YG PF + I Q +
Sbjct: 214 GSPLYASPE-IVNGR--PYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQ----IS 266
Query: 644 ATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLAN 682
+ E + P +P S+A+ IR L + R + +AN
Sbjct: 267 SGEYREPTQP---SDARGLIRWMLMVNPDRRATIEDIAN 302
>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
Length = 472
Score = 115 bits (287), Expect = 2e-25
Identities = 86/299 (28%), Positives = 139/299 (46%), Gaps = 27/299 (9%)
Query: 402 PTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREY 461
P + ++L LG G ++ VYKA+ + R KS EN E
Sbjct: 8 PPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENL----LTEI 63
Query: 462 RIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIV 521
I K + HP IV+L D F D+D ++E+C G DL ++ +++ EK AR + Q+
Sbjct: 64 EILKGIRHPHIVQLKD-FQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLA 122
Query: 522 NALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMD--DDSYGVDGMDLT 579
+AL++L+E I H DLKP NILL +K+ DFG ++ M D+ + + G L
Sbjct: 123 SALQFLHERN--ISHLDLKPQNILL-SSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL- 178
Query: 580 SQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQEN 639
Y+ PE + +VD+WS+GVI ++ L+G+ PF + E
Sbjct: 179 --------YMAPEMVC----QRQYDARVDLWSMGVILYEALFGQPPFASRSFSE---LEE 223
Query: 640 TILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL-LPHMRRSNSSG 697
I ++ P++P++S + + ++R L R P++ L HM S G
Sbjct: 224 KIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLG 282
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 113 bits (282), Expect = 7e-25
Identities = 86/291 (29%), Positives = 139/291 (47%), Gaps = 36/291 (12%)
Query: 402 PTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREY 461
PT +RY +LG+GGF++ Y+ DL + A KI ++ + ++E K E
Sbjct: 76 PTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDK----EI 131
Query: 462 RIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIV 521
+H+ L H +V+ Y YF D + +LEYC + LK K+++E E R + QIV
Sbjct: 132 ELHRILHHKHVVQFYHYFE-DKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIV 190
Query: 522 NALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQ 581
+ L+YL+E I+H DLK GN + + E+K+ DFGL+ ++ + +
Sbjct: 191 SGLKYLHE--QEILHRDLKLGNFFINEAM---ELKVGDFGLAARLEPLEHRRRTI----- 240
Query: 582 GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTI 641
GT YL PE V+ K+ + D+W++G + + L GR PF E T
Sbjct: 241 -CGTPNYLSPE--VLNKQGHGCES--DIWALGCVMYTMLLGRPPF-----------ETTN 284
Query: 642 LKAT-----EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLL 687
LK T E ++ + + + AK I L+ EDR + + + L
Sbjct: 285 LKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFL 335
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 111 bits (277), Expect = 3e-24
Identities = 91/284 (32%), Positives = 137/284 (48%), Gaps = 14/284 (4%)
Query: 404 LNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE-NYHKHACREYR 462
L + Y++ LG G EV AF+ + A+KI K +E + + E
Sbjct: 259 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 318
Query: 463 IHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVN 522
I K+L+HP I+K+ ++F D + + VLE EG +L + +K + E + Q++
Sbjct: 319 ILKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 376
Query: 523 ALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQG 582
A++YL+E IIH DLKP N+LL IKITDFG SKI+ + S L
Sbjct: 377 AVQYLHE--NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS-------LMRTL 427
Query: 583 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTIL 642
GT YL PE +V + VD WS+GVI F CL G PF +++Q + + T
Sbjct: 428 CGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSG 486
Query: 643 KATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 686
K + V VS +A +++ L + RF + P+L
Sbjct: 487 KYNFIP-EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 529
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 111 bits (277), Expect = 3e-24
Identities = 91/284 (32%), Positives = 137/284 (48%), Gaps = 14/284 (4%)
Query: 404 LNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE-NYHKHACREYR 462
L + Y++ LG G EV AF+ + A+KI K +E + + E
Sbjct: 216 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 275
Query: 463 IHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVN 522
I K+L+HP I+K+ ++F D + + VLE EG +L + +K + E + Q++
Sbjct: 276 ILKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 333
Query: 523 ALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQG 582
A++YL+E IIH DLKP N+LL IKITDFG SKI+ + S L
Sbjct: 334 AVQYLHE--NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS-------LMRTL 384
Query: 583 AGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTIL 642
GT YL PE +V + VD WS+GVI F CL G PF +++Q + + T
Sbjct: 385 CGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSG 443
Query: 643 KATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 686
K + V VS +A +++ L + RF + P+L
Sbjct: 444 KYNFIP-EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 110 bits (276), Expect = 3e-24
Identities = 86/299 (28%), Positives = 145/299 (48%), Gaps = 25/299 (8%)
Query: 389 RINNEDNSQFKDHPT-LNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRD 447
R +D S +K T + + ++ + +LG G FSEV+ + A+K + + ++RD
Sbjct: 3 RKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD 62
Query: 448 EKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKL 507
EN E + K++ H IV L D + T + V++ G +L + + +
Sbjct: 63 SSLEN-------EIAVLKKIKHENIVTLEDIYE-STTHYYLVMQLVSGGELFDRILERGV 114
Query: 508 MSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMD 567
+EK+A ++ Q+++A++YL+E I+H DLKP N+L + +I ITDFGLSK+
Sbjct: 115 YTEKDASLVIQQVLSAVKYLHE--NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQ 172
Query: 568 DDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFG 627
+ + S GT Y+ PE V+ ++P S VD WS+GVI + L G PF
Sbjct: 173 N--------GIMSTACGTPGYVAPE--VLAQKP--YSKAVDCWSIGVITYILLCGYPPF- 219
Query: 628 HNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 686
+ + L E E + P +S AK FI L +R+ + + P++
Sbjct: 220 -YEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
>gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
Length = 275
Score = 109 bits (273), Expect = 8e-24
Identities = 89/282 (31%), Positives = 138/282 (48%), Gaps = 34/282 (12%)
Query: 414 LGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIV 473
LG+G F VY A ++ + V + L KS +KE RE I L HP I+
Sbjct: 15 LGKGKFGNVYLA--RLKESHFIVALKVLFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 70
Query: 474 KLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPP 533
+LY+YF D +LEY +L L++ + + E+ +I+ ++ +AL Y ++ K
Sbjct: 71 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 127
Query: 534 IIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPEC 593
+IH D+KP N+LL GE+KI DFG S + S M GT YLPPE
Sbjct: 128 VIHRDIKPENLLL---GFRGEVKIADFGWS--VHTPSLRRKTM------CGTLDYLPPEM 176
Query: 594 FVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF---GHNQSQQDILQENTILKATEVQFP 650
E KVD+W +GV+ ++ L G PF H+++ + IL+ +V+FP
Sbjct: 177 I----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRFP 225
Query: 651 VKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRR 692
+ + A+ I R L Y+ +R + Q+ P++ H RR
Sbjct: 226 LSMPLG--ARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 265
>gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
Length = 290
Score = 109 bits (273), Expect = 8e-24
Identities = 89/282 (31%), Positives = 138/282 (48%), Gaps = 34/282 (12%)
Query: 414 LGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIV 473
LG+G F VY A ++ + V + L KS +KE RE I L HP I+
Sbjct: 30 LGKGKFGNVYLA--RLKESHFIVALKVLFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 85
Query: 474 KLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPP 533
+LY+YF D +LEY +L L++ + + E+ +I+ ++ +AL Y ++ K
Sbjct: 86 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 142
Query: 534 IIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPEC 593
+IH D+KP N+LL GE+KI DFG S + S M GT YLPPE
Sbjct: 143 VIHRDIKPENLLL---GFRGEVKIADFGWS--VHTPSLRRKTM------CGTLDYLPPEM 191
Query: 594 FVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF---GHNQSQQDILQENTILKATEVQFP 650
E KVD+W +GV+ ++ L G PF H+++ + IL+ +V+FP
Sbjct: 192 I----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRFP 240
Query: 651 VKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRR 692
+ + A+ I R L Y+ +R + Q+ P++ H RR
Sbjct: 241 LSMPLG--ARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 280
>gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
Length = 309
Score = 109 bits (273), Expect = 8e-24
Identities = 89/282 (31%), Positives = 138/282 (48%), Gaps = 34/282 (12%)
Query: 414 LGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIV 473
LG+G F VY A ++ + V + L KS +KE RE I L HP I+
Sbjct: 49 LGKGKFGNVYLA--RLKESHFIVALKVLFKS--QIEKEGLEHQLRREIEIQAHLQHPNIL 104
Query: 474 KLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPP 533
+LY+YF D +LEY +L L++ + + E+ +I+ ++ +AL Y ++ K
Sbjct: 105 RLYNYFH-DARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKK-- 161
Query: 534 IIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPEC 593
+IH D+KP N+LL GE+KI DFG S + S M GT YLPPE
Sbjct: 162 VIHRDIKPENLLL---GFRGEVKIADFGWS--VHTPSLRRKTM------CGTLDYLPPEM 210
Query: 594 FVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF---GHNQSQQDILQENTILKATEVQFP 650
E KVD+W +GV+ ++ L G PF H+++ + IL+ +V+FP
Sbjct: 211 I----EGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILK-------VDVRFP 259
Query: 651 VKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRR 692
+ + A+ I R L Y+ +R + Q+ P++ H RR
Sbjct: 260 LSMPLG--ARDLISRLLRYQPLERLPLAQILKHPWVQAHSRR 299
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 108 bits (270), Expect = 2e-23
Identities = 87/295 (29%), Positives = 145/295 (49%), Gaps = 26/295 (8%)
Query: 394 DNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVK-IHQLNKSWRDEKKEN 452
+ ++K + + Y +LG G FSEV A D Q+ A+K I + ++ EN
Sbjct: 6 EGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMEN 65
Query: 453 YHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKE 512
E + ++ HP IV L D + + +++ G +L + + +E++
Sbjct: 66 -------EIAVLHKIKHPNIVALDDIYESGGHLYL-IMQLVSGGELFDRIVEKGFYTERD 117
Query: 513 ARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYG 572
A ++ Q+++A++YL+++ I+H DLKP N+L +I I+DFGLSK+ D S
Sbjct: 118 ASRLIFQVLDAVKYLHDLG--IVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGS-- 173
Query: 573 VDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQ 632
+ S GT Y+ PE V+ ++P S VD WS+GVI + L G PF ++++
Sbjct: 174 -----VLSTACGTPGYVAPE--VLAQKP--YSKAVDCWSIGVIAYILLCGYPPF-YDEND 223
Query: 633 QDILQENTILKAT-EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 686
+ ++ ILKA E P +S AK FIR + E RF Q P++
Sbjct: 224 AKLFEQ--ILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 107 bits (268), Expect = 3e-23
Identities = 86/285 (30%), Positives = 138/285 (48%), Gaps = 33/285 (11%)
Query: 406 ERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHK 465
E + + +LLG+G F+ VY+A ++ A+K+ + K + E +IH
Sbjct: 10 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMY----KAGMVQRVQNEVKIHC 65
Query: 466 ELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQH-KLMSEKEARSIVMQIVNAL 524
+L HP I++LY+YF D++ VLE C +++ YLK K SE EAR + QI+ +
Sbjct: 66 QLKHPSILELYNYFE-DSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGM 124
Query: 525 RYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLS---KIMDDDSYGVDGMDLTSQ 581
YL+ I+H DL N+LL T IKI DFGL+ K+ + Y +
Sbjct: 125 LYLH--SHGILHRDLTLSNLLL---TRNMNIKIADFGLATQLKMPHEKHYTL-------- 171
Query: 582 GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTI 641
GT Y+ PE + + + + DVWS+G +F+ L GR PF + +NT+
Sbjct: 172 -CGTPNYISPE--IATRSAHGLES--DVWSLGCMFYTLLIGRPPFDTD------TVKNTL 220
Query: 642 LKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 686
K + + +S EAK I + L DR + + + P++
Sbjct: 221 NKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM 265
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 107 bits (266), Expect = 5e-23
Identities = 93/283 (32%), Positives = 136/283 (48%), Gaps = 35/283 (12%)
Query: 408 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKI---HQLNKSWRDEKKENYHKHACREYRIH 464
Y LL +G+G F++V A + R A+KI QLN S + RE RI
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQK--------LFREVRIM 110
Query: 465 KELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNAL 524
K L+HP IVKL++ + T V+EY ++ YL H M EKEAR+ QIV+A+
Sbjct: 111 KGLNHPNIVKLFEVIETEK-TLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAV 169
Query: 525 RYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAG 584
Y ++ I+H DLK N+LL A IKI DFG S ++ + G G
Sbjct: 170 HYCHQ--KNIVHRDLKAENLLL---DAEANIKIADFGFS---NEFTLG----SKLDTFCG 217
Query: 585 TYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILK 643
+ Y PE F K +VD+WS+GVI + + G PF GHN + L+E +
Sbjct: 218 SPPYAAPELFQGKKYD---GPEVDIWSLGVILYTLVSGSLPFDGHNLKE---LRERVLRG 271
Query: 644 ATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 686
V F +S++ ++ +RR L R + Q+ D ++
Sbjct: 272 KYRVPF----YMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 310
>gi|23308722 TTK protein kinase [Homo sapiens]
Length = 857
Score = 106 bits (265), Expect = 7e-23
Identities = 84/291 (28%), Positives = 143/291 (49%), Gaps = 36/291 (12%)
Query: 408 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 467
Y +L +G GG S+V++ + +Q YA +K L ++ ++ ++Y ++ +
Sbjct: 525 YSILKQIGSGGSSKVFQVLNEKKQIYA-IKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 582
Query: 468 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 527
D +I++LYDY TD + ++ C DL+ +LK+ K + E +S ++ A+ +
Sbjct: 583 D--KIIRLYDYEI--TDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 638
Query: 528 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 587
++ I+H DLKP N L+VDG +K+ DFG++ M D+ V + GT
Sbjct: 639 HQ--HGIVHSDLKPANFLIVDGM----LKLIDFGIANQMQPDTTSV----VKDSQVGTVN 688
Query: 588 YLPPECFVV-------GKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENT 640
Y+PPE GK KIS K DVWS+G I + YG+ PF Q I+ + +
Sbjct: 689 YMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQIS 742
Query: 641 ILKAT-----EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 686
L A E++FP P + + ++ CL + R + +L PY+
Sbjct: 743 KLHAIIDPNHEIEFPDIP--EKDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 105 bits (263), Expect = 1e-22
Identities = 93/311 (29%), Positives = 145/311 (46%), Gaps = 28/311 (9%)
Query: 406 ERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHK 465
E+Y +L ++G G F VYK Y + A+K + K R EK+ ++ RE I +
Sbjct: 2 EKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKF--IPKLGRSEKE---LRNLQREIEIMR 56
Query: 466 ELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALR 525
L HP IV + D F D + V +Y EG +L L+ + E + ++I Q+V+AL
Sbjct: 57 GLRHPNIVHMLDSFETDKEV-VVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALY 114
Query: 526 YLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGT 585
YL+ + I+H D+KP NILL G G IK+ DFG ++ M ++ M LTS GT
Sbjct: 115 YLHSHR--ILHRDMKPQNILLAKG---GGIKLCDFGFARAMSTNT-----MVLTSI-KGT 163
Query: 586 YWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKAT 645
Y+ PE +V + P + D+WSVG I ++ G PF I Q +++
Sbjct: 164 PLYMSPE--LVEERP--YDHTADLWSVGCILYELAVGTPPF----YATSIFQLVSLILKD 215
Query: 646 EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLT 705
V++P +S K F++ L R L P++ H+ +
Sbjct: 216 PVRWP--STISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPF 273
Query: 706 ASPTPPSSSII 716
S PP ++
Sbjct: 274 TSRLPPELQVL 284
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 105 bits (261), Expect = 2e-22
Identities = 88/279 (31%), Positives = 139/279 (49%), Gaps = 29/279 (10%)
Query: 411 LHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHP 470
L ++G+G F +V A + ++ AVK+ L K +KE H A R + K + HP
Sbjct: 165 LKVIGKGSFGKVLLAKRKLDGKFYAVKV--LQKKIVLNRKEQKHIMAERNVLL-KNVKHP 221
Query: 471 RIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEI 530
+V L+ F T+ VL++ G +L F+L++ + E AR +I +AL YL+ I
Sbjct: 222 FLVGLHYSFQT-TEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
Query: 531 KPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLP 590
K I++ DLKP NILL + G + +TDFGL K G+ D T+ GT YL
Sbjct: 281 K--IVYRDLKPENILL---DSVGHVVLTDFGLCK------EGIAISDTTTTFCGTPEYLA 329
Query: 591 PECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFP 650
PE V+ K+P N VD W +G + ++ LYG PF + + +N + K
Sbjct: 330 PE--VIRKQP--YDNTVDWWCLGAVLYEMLYGLPPFYCRDVAE--MYDNILHK----PLS 379
Query: 651 VKPVVSSEAKAFIRRCLAYRKEDRF----DVHQLANDPY 685
++P VS A + + L +++R D ++ N P+
Sbjct: 380 LRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPF 418
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 105 bits (261), Expect = 2e-22
Identities = 88/279 (31%), Positives = 139/279 (49%), Gaps = 29/279 (10%)
Query: 411 LHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHP 470
L ++G+G F +V A + ++ AVK+ L K +KE H A R + K + HP
Sbjct: 165 LKVIGKGSFGKVLLAKRKLDGKFYAVKV--LQKKIVLNRKEQKHIMAERNVLL-KNVKHP 221
Query: 471 RIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEI 530
+V L+ F T+ VL++ G +L F+L++ + E AR +I +AL YL+ I
Sbjct: 222 FLVGLHYSFQT-TEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
Query: 531 KPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLP 590
K I++ DLKP NILL + G + +TDFGL K G+ D T+ GT YL
Sbjct: 281 K--IVYRDLKPENILL---DSVGHVVLTDFGLCK------EGIAISDTTTTFCGTPEYLA 329
Query: 591 PECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFP 650
PE V+ K+P N VD W +G + ++ LYG PF + + +N + K
Sbjct: 330 PE--VIRKQP--YDNTVDWWCLGAVLYEMLYGLPPFYCRDVAE--MYDNILHK----PLS 379
Query: 651 VKPVVSSEAKAFIRRCLAYRKEDRF----DVHQLANDPY 685
++P VS A + + L +++R D ++ N P+
Sbjct: 380 LRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPF 418
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 104 bits (259), Expect = 3e-22
Identities = 87/295 (29%), Positives = 133/295 (45%), Gaps = 42/295 (14%)
Query: 413 LLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHAC---REYRIHKELDH 469
L+G G F+ V+K + H L + + K+N K +E +I KEL H
Sbjct: 21 LIGHGAFAVVFKGRHREK--------HDLEVAVKCINKKNLAKSQTLLGKEIKILKELKH 72
Query: 470 PRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNE 529
IV LYD+ + + V+EYC G DL YL + +SE R + QI A+R L+
Sbjct: 73 ENIVALYDFQEMANSVYL-VMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLH- 130
Query: 530 IKPPIIHYDLKPGNILLVDGTA------CGEIKITDFGLSKIMDDDSYGVDGMDLTSQGA 583
IIH DLKP NILL + +KI DFG ++ + + + +
Sbjct: 131 -SKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNM-------MAATLC 182
Query: 584 GTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDI---LQENT 640
G+ Y+ PE + K D+WS+G I +QCL G+ PF S QD+ ++N
Sbjct: 183 GSPMYMAPEVIM----SQHYDGKADLWSIGTIVYQCLTGKAPF-QASSPQDLRLFYEKNK 237
Query: 641 ILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL--LPHMRRS 693
L T + S+ + + L +DR D + + P+L P +R+S
Sbjct: 238 TLVPT-----IPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKS 287
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 104 bits (259), Expect = 3e-22
Identities = 113/399 (28%), Positives = 175/399 (43%), Gaps = 40/399 (10%)
Query: 278 VKQQEWVNQQREDIE--RQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAE--NDP 333
+ ++ WV ++ E I+ R R L K + P P N +V +
Sbjct: 6 IVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTE 65
Query: 334 FVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAE-IQAELERLERVRNLHIR-----EL 387
+PN + L E F + ++E E IQA +RL+R + ++
Sbjct: 66 RPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQI 125
Query: 388 KRINNEDNSQFKDH---PTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKS 444
I E+ H T+N+ + L LLG+G F +V + +Y A+KI L K
Sbjct: 126 DNIGEEEMDASTTHHKRKTMND-FDYLKLLGKGTFGKVILVREKASGKYYAMKI--LKKE 182
Query: 445 WRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQ 504
K E H E R+ K HP + L Y D C V+EY G +L F+L +
Sbjct: 183 VIIAKDEV--AHTLTESRVLKNTRHPFLTSL-KYSFQTKDRLCFVMEYVNGGELFFHLSR 239
Query: 505 HKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSK 564
++ SE R +IV+AL YL+ K I++ DLK N++L G IKITDFGL K
Sbjct: 240 ERVFSEDRTRFYGAEIVSALDYLHSGK--IVYRDLKLENLML---DKDGHIKITDFGLCK 294
Query: 565 IMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRK 624
G+ GT YL PE E VD W +GV+ ++ + GR
Sbjct: 295 ------EGITDAATMKTFCGTPEYLAPEVL----EDNDYGRAVDWWGLGVVMYEMMCGRL 344
Query: 625 PFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFI 663
PF +NQ + + + ++ +++FP +SS+AK+ +
Sbjct: 345 PF-YNQDHEKLFE---LILMEDIKFP--RTLSSDAKSLL 377
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 104 bits (259), Expect = 3e-22
Identities = 113/399 (28%), Positives = 175/399 (43%), Gaps = 40/399 (10%)
Query: 278 VKQQEWVNQQREDIE--RQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAE--NDP 333
+ ++ WV ++ E I+ R R L K + P P N +V +
Sbjct: 6 IVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTE 65
Query: 334 FVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAE-IQAELERLERVRNLHIR-----EL 387
+PN + L E F + ++E E IQA +RL+R + ++
Sbjct: 66 RPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQI 125
Query: 388 KRINNEDNSQFKDH---PTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKS 444
I E+ H T+N+ + L LLG+G F +V + +Y A+KI L K
Sbjct: 126 DNIGEEEMDASTTHHKRKTMND-FDYLKLLGKGTFGKVILVREKASGKYYAMKI--LKKE 182
Query: 445 WRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQ 504
K E H E R+ K HP + L Y D C V+EY G +L F+L +
Sbjct: 183 VIIAKDEV--AHTLTESRVLKNTRHPFLTSL-KYSFQTKDRLCFVMEYVNGGELFFHLSR 239
Query: 505 HKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSK 564
++ SE R +IV+AL YL+ K I++ DLK N++L G IKITDFGL K
Sbjct: 240 ERVFSEDRTRFYGAEIVSALDYLHSGK--IVYRDLKLENLML---DKDGHIKITDFGLCK 294
Query: 565 IMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRK 624
G+ GT YL PE E VD W +GV+ ++ + GR
Sbjct: 295 ------EGITDAATMKTFCGTPEYLAPEVL----EDNDYGRAVDWWGLGVVMYEMMCGRL 344
Query: 625 PFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFI 663
PF +NQ + + + ++ +++FP +SS+AK+ +
Sbjct: 345 PF-YNQDHEKLFE---LILMEDIKFP--RTLSSDAKSLL 377
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 104 bits (259), Expect = 3e-22
Identities = 85/280 (30%), Positives = 137/280 (48%), Gaps = 27/280 (9%)
Query: 408 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 467
Y L LGRG F+ V A ++ AVK+ ++K+ D H +E R K +
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKV--IDKTKLDTLATG---HLFQEVRCMKLV 70
Query: 468 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDL-DFYLKQHKLMSEKEARSIVMQIVNALRY 526
HP IV+LY+ T + +LE +G D+ D+ +K + ++E A+ QIV+A+ Y
Sbjct: 71 QHPNIVRLYEVIDTQTKLY-LILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 129
Query: 527 LNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTY 586
+++ ++H DLKP N++ + G +K+TDFG S G LT+ G+
Sbjct: 130 CHKLH--VVHRDLKPENVVFFEKQ--GLVKLTDFGFSNKFQ------PGKKLTT-SCGSL 178
Query: 587 WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE 646
Y PE ++G E + VD+WS+GVI F + G+ PF Q+ T+ +
Sbjct: 179 AYSAPE-ILLGDEYD--APAVDIWSLGVILFMLVCGQPPF------QEANDSETLTMIMD 229
Query: 647 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 686
++ V VS E K I R L + R + ++ N P+L
Sbjct: 230 CKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWL 269
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 104 bits (259), Expect = 3e-22
Identities = 85/280 (30%), Positives = 137/280 (48%), Gaps = 27/280 (9%)
Query: 408 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 467
Y L LGRG F+ V A ++ AVK+ ++K+ D H +E R K +
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKV--IDKTKLDTLATG---HLFQEVRCMKLV 70
Query: 468 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDL-DFYLKQHKLMSEKEARSIVMQIVNALRY 526
HP IV+LY+ T + +LE +G D+ D+ +K + ++E A+ QIV+A+ Y
Sbjct: 71 QHPNIVRLYEVIDTQTKLY-LILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 129
Query: 527 LNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTY 586
+++ ++H DLKP N++ + G +K+TDFG S G LT+ G+
Sbjct: 130 CHKLH--VVHRDLKPENVVFFEKQ--GLVKLTDFGFSNKFQ------PGKKLTT-SCGSL 178
Query: 587 WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE 646
Y PE ++G E + VD+WS+GVI F + G+ PF Q+ T+ +
Sbjct: 179 AYSAPE-ILLGDEYD--APAVDIWSLGVILFMLVCGQPPF------QEANDSETLTMIMD 229
Query: 647 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 686
++ V VS E K I R L + R + ++ N P+L
Sbjct: 230 CKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWL 269
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 103 bits (258), Expect = 4e-22
Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 29/280 (10%)
Query: 408 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 467
Y LL +G+G F++V A + R A+KI + + + RE RI K L
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPTSLQKLFREVRIMKIL 110
Query: 468 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 527
+HP IVKL++ + T ++EY G ++ YL H M EKEARS QIV+A++Y
Sbjct: 111 NHPNIVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169
Query: 528 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 587
++ + I+H DLK N+LL A IKI DFG S + + V G T G+
Sbjct: 170 HQKR--IVHRDLKAENLLL---DADMNIKIADFGFS-----NEFTVGGKLDTFCGSPP-- 217
Query: 588 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILKATE 646
Y PE F K +VDVWS+GVI + + G PF G N + L+E +
Sbjct: 218 YAAPELFQGKKYD---GPEVDVWSLGVILYTLVSGSLPFDGQNLKE---LRERVLRGKYR 271
Query: 647 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 686
+ F +S++ + ++R L R + Q+ D ++
Sbjct: 272 IPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 103 bits (258), Expect = 4e-22
Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 29/280 (10%)
Query: 408 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 467
Y LL +G+G F++V A + R A+KI + + + RE RI K L
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPTSLQKLFREVRIMKIL 110
Query: 468 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 527
+HP IVKL++ + T ++EY G ++ YL H M EKEARS QIV+A++Y
Sbjct: 111 NHPNIVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169
Query: 528 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 587
++ + I+H DLK N+LL A IKI DFG S + + V G T G+
Sbjct: 170 HQKR--IVHRDLKAENLLL---DADMNIKIADFGFS-----NEFTVGGKLDTFCGSPP-- 217
Query: 588 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILKATE 646
Y PE F K +VDVWS+GVI + + G PF G N + L+E +
Sbjct: 218 YAAPELFQGKKYD---GPEVDVWSLGVILYTLVSGSLPFDGQNLKE---LRERVLRGKYR 271
Query: 647 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 686
+ F +S++ + ++R L R + Q+ D ++
Sbjct: 272 IPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 103 bits (258), Expect = 4e-22
Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 29/280 (10%)
Query: 408 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 467
Y LL +G+G F++V A + R A+KI + + + RE RI K L
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPTSLQKLFREVRIMKIL 110
Query: 468 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 527
+HP IVKL++ + T ++EY G ++ YL H M EKEARS QIV+A++Y
Sbjct: 111 NHPNIVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169
Query: 528 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 587
++ + I+H DLK N+LL A IKI DFG S + + V G T G+
Sbjct: 170 HQKR--IVHRDLKAENLLL---DADMNIKIADFGFS-----NEFTVGGKLDTFCGSPP-- 217
Query: 588 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILKATE 646
Y PE F K +VDVWS+GVI + + G PF G N + L+E +
Sbjct: 218 YAAPELFQGKKYD---GPEVDVWSLGVILYTLVSGSLPFDGQNLKE---LRERVLRGKYR 271
Query: 647 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 686
+ F +S++ + ++R L R + Q+ D ++
Sbjct: 272 IPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 103 bits (258), Expect = 4e-22
Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 29/280 (10%)
Query: 408 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 467
Y LL +G+G F++V A + R A+KI + + + RE RI K L
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIID-----KTQLNPTSLQKLFREVRIMKIL 110
Query: 468 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 527
+HP IVKL++ + T ++EY G ++ YL H M EKEARS QIV+A++Y
Sbjct: 111 NHPNIVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 169
Query: 528 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 587
++ + I+H DLK N+LL A IKI DFG S + + V G T G+
Sbjct: 170 HQKR--IVHRDLKAENLLL---DADMNIKIADFGFS-----NEFTVGGKLDTFCGSPP-- 217
Query: 588 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPF-GHNQSQQDILQENTILKATE 646
Y PE F K +VDVWS+GVI + + G PF G N + L+E +
Sbjct: 218 YAAPELFQGKKYD---GPEVDVWSLGVILYTLVSGSLPFDGQNLKE---LRERVLRGKYR 271
Query: 647 VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 686
+ F +S++ + ++R L R + Q+ D ++
Sbjct: 272 IPF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,063,895
Number of Sequences: 37866
Number of extensions: 1389645
Number of successful extensions: 9323
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 235
Number of HSP's successfully gapped in prelim test: 816
Number of HSP's that attempted gapping in prelim test: 6968
Number of HSP's gapped (non-prelim): 2008
length of query: 718
length of database: 18,247,518
effective HSP length: 110
effective length of query: 608
effective length of database: 14,082,258
effective search space: 8562012864
effective search space used: 8562012864
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.