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Search of human proteins with 209571547
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|209571547 kelch repeat and BTB (POZ) domain containing 4
isoform a [Homo sapiens]
(534 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209571547 kelch repeat and BTB (POZ) domain containing 4 isof... 1087 0.0
gi|209693446 kelch repeat and BTB (POZ) domain containing 4 isof... 1054 0.0
gi|40018614 DRE1 protein [Homo sapiens] 166 6e-41
gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Hom... 127 2e-29
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 120 3e-27
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 120 3e-27
gi|166235129 kelch-like 3 [Homo sapiens] 117 3e-26
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 116 4e-26
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 115 8e-26
gi|109150407 kelch-like 6 [Homo sapiens] 115 1e-25
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 114 2e-25
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 113 5e-25
gi|55925604 kelch-like 18 [Homo sapiens] 112 6e-25
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 112 1e-24
gi|40807500 kelch-like 20 [Homo sapiens] 110 4e-24
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 109 5e-24
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 109 5e-24
gi|11056006 kelch-like 12 [Homo sapiens] 109 7e-24
gi|11545731 gigaxonin [Homo sapiens] 105 1e-22
gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Hom... 105 1e-22
gi|55925608 kelch-like 21 [Homo sapiens] 104 2e-22
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 103 4e-22
gi|223890235 intracisternal A particle-promoted polypeptide isof... 103 4e-22
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 103 4e-22
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 103 4e-22
gi|38194229 kelch-like 17 [Homo sapiens] 103 5e-22
gi|45643138 kelch-like 13 [Homo sapiens] 102 1e-21
gi|227497736 T-cell activation kelch repeat protein [Homo sapiens] 101 1e-21
gi|38327518 BTB and kelch domain containing 3 [Homo sapiens] 101 2e-21
gi|38327516 BTB and kelch domain containing 3 [Homo sapiens] 101 2e-21
>gi|209571547 kelch repeat and BTB (POZ) domain containing 4 isoform
a [Homo sapiens]
Length = 534
Score = 1087 bits (2810), Expect = 0.0
Identities = 534/534 (100%), Positives = 534/534 (100%)
Query: 1 MKGGNADSWQREKLASMESPEEPGASMDENYFVNYTFKDRSHSGRVAQGIMKLCLEEELF 60
MKGGNADSWQREKLASMESPEEPGASMDENYFVNYTFKDRSHSGRVAQGIMKLCLEEELF
Sbjct: 1 MKGGNADSWQREKLASMESPEEPGASMDENYFVNYTFKDRSHSGRVAQGIMKLCLEEELF 60
Query: 61 ADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLLVDYIY 120
ADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLLVDYIY
Sbjct: 61 ADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLLVDYIY 120
Query: 121 HGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPELYT 180
HGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPELYT
Sbjct: 121 HGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPELYT 180
Query: 181 AAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISDGVPCSQNPTEAIEAWINFNKEEREAFA 240
AAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISDGVPCSQNPTEAIEAWINFNKEEREAFA
Sbjct: 181 AAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISDGVPCSQNPTEAIEAWINFNKEEREAFA 240
Query: 241 ESLRTSLKEIGENVHIYLIGKESSRTHSLAVSLHCAEDDSISVSGQNSLCHQITAACKHG 300
ESLRTSLKEIGENVHIYLIGKESSRTHSLAVSLHCAEDDSISVSGQNSLCHQITAACKHG
Sbjct: 241 ESLRTSLKEIGENVHIYLIGKESSRTHSLAVSLHCAEDDSISVSGQNSLCHQITAACKHG 300
Query: 301 GDLYVVGGSIPRRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTL 360
GDLYVVGGSIPRRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTL
Sbjct: 301 GDLYVVGGSIPRRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTL 360
Query: 361 SNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQCFD 420
SNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQCFD
Sbjct: 361 SNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQCFD 420
Query: 421 TETDKCHVKPYVLPFAGRMHAAVHKDLVFIVAEGDSLVCYNPLLDSFTRLCLPEAWSSAP 480
TETDKCHVKPYVLPFAGRMHAAVHKDLVFIVAEGDSLVCYNPLLDSFTRLCLPEAWSSAP
Sbjct: 421 TETDKCHVKPYVLPFAGRMHAAVHKDLVFIVAEGDSLVCYNPLLDSFTRLCLPEAWSSAP 480
Query: 481 SLWKIASCNGSIYVFRDRYKKGDANTYKLDPATSAVTVTRGIKVLLTNLQFVLA 534
SLWKIASCNGSIYVFRDRYKKGDANTYKLDPATSAVTVTRGIKVLLTNLQFVLA
Sbjct: 481 SLWKIASCNGSIYVFRDRYKKGDANTYKLDPATSAVTVTRGIKVLLTNLQFVLA 534
>gi|209693446 kelch repeat and BTB (POZ) domain containing 4 isoform
b [Homo sapiens]
Length = 518
Score = 1054 bits (2725), Expect = 0.0
Identities = 518/518 (100%), Positives = 518/518 (100%)
Query: 17 MESPEEPGASMDENYFVNYTFKDRSHSGRVAQGIMKLCLEEELFADVTISVEGREFQLHR 76
MESPEEPGASMDENYFVNYTFKDRSHSGRVAQGIMKLCLEEELFADVTISVEGREFQLHR
Sbjct: 1 MESPEEPGASMDENYFVNYTFKDRSHSGRVAQGIMKLCLEEELFADVTISVEGREFQLHR 60
Query: 77 LVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLLVDYIYHGTVKLRAEELQEIYE 136
LVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLLVDYIYHGTVKLRAEELQEIYE
Sbjct: 61 LVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLLVDYIYHGTVKLRAEELQEIYE 120
Query: 137 VSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPELYTAAKHCAKTHLAQLQNT 196
VSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPELYTAAKHCAKTHLAQLQNT
Sbjct: 121 VSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPELYTAAKHCAKTHLAQLQNT 180
Query: 197 EEFLHLPHRLLTDIISDGVPCSQNPTEAIEAWINFNKEEREAFAESLRTSLKEIGENVHI 256
EEFLHLPHRLLTDIISDGVPCSQNPTEAIEAWINFNKEEREAFAESLRTSLKEIGENVHI
Sbjct: 181 EEFLHLPHRLLTDIISDGVPCSQNPTEAIEAWINFNKEEREAFAESLRTSLKEIGENVHI 240
Query: 257 YLIGKESSRTHSLAVSLHCAEDDSISVSGQNSLCHQITAACKHGGDLYVVGGSIPRRMWK 316
YLIGKESSRTHSLAVSLHCAEDDSISVSGQNSLCHQITAACKHGGDLYVVGGSIPRRMWK
Sbjct: 241 YLIGKESSRTHSLAVSLHCAEDDSISVSGQNSLCHQITAACKHGGDLYVVGGSIPRRMWK 300
Query: 317 CNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTE 376
CNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTE
Sbjct: 301 CNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTE 360
Query: 377 TTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQCFDTETDKCHVKPYVLPFA 436
TTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQCFDTETDKCHVKPYVLPFA
Sbjct: 361 TTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQCFDTETDKCHVKPYVLPFA 420
Query: 437 GRMHAAVHKDLVFIVAEGDSLVCYNPLLDSFTRLCLPEAWSSAPSLWKIASCNGSIYVFR 496
GRMHAAVHKDLVFIVAEGDSLVCYNPLLDSFTRLCLPEAWSSAPSLWKIASCNGSIYVFR
Sbjct: 421 GRMHAAVHKDLVFIVAEGDSLVCYNPLLDSFTRLCLPEAWSSAPSLWKIASCNGSIYVFR 480
Query: 497 DRYKKGDANTYKLDPATSAVTVTRGIKVLLTNLQFVLA 534
DRYKKGDANTYKLDPATSAVTVTRGIKVLLTNLQFVLA
Sbjct: 481 DRYKKGDANTYKLDPATSAVTVTRGIKVLLTNLQFVLA 518
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 166 bits (419), Expect = 6e-41
Identities = 154/574 (26%), Positives = 246/574 (42%), Gaps = 78/574 (13%)
Query: 11 REKLASMESP--EEPGASMDENYFVNYTFKDRSHSGRVAQGIMKLCLE---EELFADVTI 65
RE L +SP + MD + F D S A+ I+++ E LF DV I
Sbjct: 11 REDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVII 70
Query: 66 SVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLLVDYIYHGTVK 125
VEG+EF HR VLSA S +FR+MF ++ +E+ ++ + + + + Y+Y G VK
Sbjct: 71 CVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVK 130
Query: 126 LRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPELYTAAKHC 185
+ E +Q ++E S ++Q++ L + C++FL + NCL + AD HS L+T K+
Sbjct: 131 ITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNF 190
Query: 186 AKTHLAQLQNTEEFLHLPHRLLTD-IISDGVPCSQNPT--EAIEAWINFNKEEREAFAES 242
A + EEFL L L D I SD + + EA+ W+ + R
Sbjct: 191 ALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHE 250
Query: 243 LRTSLK-----------------EIGENVHIYLIGKESSRTHSLAVSLHCAEDDSISVSG 285
L T ++ I + Y + E+ R H L + +G
Sbjct: 251 LLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTG 310
Query: 286 QNSLCHQITAACKHGG-------------------------------------DLYVVGG 308
+ + + + GG D+ V GG
Sbjct: 311 YSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGG 370
Query: 309 SI-PRRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYY 367
I R +W N+ W A L + R +H + + GK +Y +GG Q+ LS +V Y
Sbjct: 371 RINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGK--VYVVGGYDGQNRLS-SVECY 427
Query: 368 RVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQCFDTETDKCH 427
N WTE L+ AVS A + G ++++GG +D S +Q +D ET+
Sbjct: 428 DSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDD----NTCSDKVQSYDPETNSWL 483
Query: 428 VKPYVLPFAGRMHAAVHKDLVFIVAEG--DSLVCYNPLLDSFTRLCLPEAWSSAPSLWKI 485
++ +P A R AV + + VA G ++ CY+P+ D + + + S +
Sbjct: 484 LRA-AIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHV---QNTFSRQENCGM 539
Query: 486 ASCNGSIYVFRDRYKKGDANTYKL--DPATSAVT 517
+ CNG IY+ R + G+A L DPATS +T
Sbjct: 540 SVCNGKIYILGGRRENGEATDTILCYDPATSIIT 573
>gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 623
Score = 127 bits (320), Expect = 2e-29
Identities = 109/477 (22%), Positives = 195/477 (40%), Gaps = 80/477 (16%)
Query: 51 MKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSES 110
+KL E++LF D+ + VEG EF H++VL+ S +FR+MF S L E+ + L++V +
Sbjct: 21 LKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAA 80
Query: 111 VFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLA 170
Q+++ Y Y G + + ++++YE + Q+ + + C +L + + NC++++ A
Sbjct: 81 TLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLLSFA 140
Query: 171 DRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISD---GVPCSQNPTEAIEA 227
D S EL +AK + + + + F+ L H LL DI+S V + EA
Sbjct: 141 DLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKEETVREAAML 200
Query: 228 WINFNKEEREAFAESLRT-----SLKEIGENV----------HIYLIGKESSRTHSLAVS 272
W+ +N E R + S+ + +L E+ + + + G S
Sbjct: 201 WLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQGLYKSMPKFFKPR 260
Query: 273 LHCAEDDS---ISVSGQN------SLC------------------HQITAACKHGGDLYV 305
L +++ I S +N S+C H++ D+Y+
Sbjct: 261 LGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYI 320
Query: 306 VGGSIPRRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVI 365
GG +P + K N++ +LQ +V N
Sbjct: 321 AGGQVPLKNTKTNHSKT----------SKLQTAFRTV-------------------NCFY 351
Query: 366 YYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQCFDTETDK 425
++ N W T + + G IY +GG+ + R ++ +DTE D+
Sbjct: 352 WFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGEL---NRRTVERYDTEKDE 408
Query: 426 -CHVKPYVLPFAGRMHAAVHKDLVFIVAEGDSLVCYNPLLDSFTRLCLPEAWSSAPS 481
V P LP A + AAV V + + CY P DS+ + + + S S
Sbjct: 409 WTMVSP--LPCAWQWSAAVVVHDCIYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFAS 463
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 120 bits (301), Expect = 3e-27
Identities = 95/366 (25%), Positives = 166/366 (45%), Gaps = 17/366 (4%)
Query: 50 IMKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSE 109
+M + L DVTI E E HR+VL+A S +F +MFT + E+ + + +++V
Sbjct: 49 VMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDG 108
Query: 110 SVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWL 169
++L+DY+Y +++ E +Q + + + QL + + C FL + NCL +
Sbjct: 109 WTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAF 168
Query: 170 ADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISDG---VPCSQNPTEAIE 226
AD H+ +L A A+ H A + +EEFL+L + +IS + + EA+
Sbjct: 169 ADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVI 228
Query: 227 AWINFNKEEREAFAESL--RTSLKEIGENVHIYLIGKESSRTHSLAVSLHCAEDDSISV- 283
AW+N +K+ R+ F L L + + + +E+ +S A + E +
Sbjct: 229 AWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLL 288
Query: 284 -SGQNSLCHQITAACKHGGDL----YVVGGSIPR--RMWKCNNATVD-WEWCAPLPRDRL 335
+ Q L + + +L VVGG P+ R +C + + W A LP R
Sbjct: 289 PTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRC 348
Query: 336 QHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGI 395
+ +V + G ++++GG + Y V D WT + S A LNG+
Sbjct: 349 RAGMVYMAG--LVFAVGGFNGSLRVRTVDSYDPVKDQ-WTSVANMRDRRSTLGAAVLNGL 405
Query: 396 IYLLGG 401
+Y +GG
Sbjct: 406 LYAVGG 411
Score = 34.3 bits (77), Expect = 0.29
Identities = 43/183 (23%), Positives = 68/183 (37%), Gaps = 26/183 (14%)
Query: 301 GDLYVVGG--------SIPRRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLG 352
G LY VGG S+ K N +W AP+ R + V G +Y++G
Sbjct: 404 GLLYAVGGFDGSTGLSSVEAYNIKSN----EWFHVAPMNTRRSSVGVGVVGG--LLYAVG 457
Query: 353 GKT-LQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTK 411
G + V Y N WT ++ SGA LN ++Y +GG + L
Sbjct: 458 GYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL----- 512
Query: 412 PSRLIQCFDTETDKCHVKPYVLPFAGRMHAAVHKDLVFIVAEGD------SLVCYNPLLD 465
+ ++ +D T+ + L+++V D S+ YNP D
Sbjct: 513 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 572
Query: 466 SFT 468
+T
Sbjct: 573 KWT 575
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 120 bits (301), Expect = 3e-27
Identities = 95/366 (25%), Positives = 166/366 (45%), Gaps = 17/366 (4%)
Query: 50 IMKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSE 109
+M + L DVTI E E HR+VL+A S +F +MFT + E+ + + +++V
Sbjct: 45 VMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDG 104
Query: 110 SVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWL 169
++L+DY+Y +++ E +Q + + + QL + + C FL + NCL +
Sbjct: 105 WTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAF 164
Query: 170 ADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISDG---VPCSQNPTEAIE 226
AD H+ +L A A+ H A + +EEFL+L + +IS + + EA+
Sbjct: 165 ADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVI 224
Query: 227 AWINFNKEEREAFAESL--RTSLKEIGENVHIYLIGKESSRTHSLAVSLHCAEDDSISV- 283
AW+N +K+ R+ F L L + + + +E+ +S A + E +
Sbjct: 225 AWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLL 284
Query: 284 -SGQNSLCHQITAACKHGGDL----YVVGGSIPR--RMWKCNNATVD-WEWCAPLPRDRL 335
+ Q L + + +L VVGG P+ R +C + + W A LP R
Sbjct: 285 PTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRC 344
Query: 336 QHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGI 395
+ +V + G ++++GG + Y V D WT + S A LNG+
Sbjct: 345 RAGMVYMAG--LVFAVGGFNGSLRVRTVDSYDPVKDQ-WTSVANMRDRRSTLGAAVLNGL 401
Query: 396 IYLLGG 401
+Y +GG
Sbjct: 402 LYAVGG 407
Score = 34.3 bits (77), Expect = 0.29
Identities = 43/183 (23%), Positives = 68/183 (37%), Gaps = 26/183 (14%)
Query: 301 GDLYVVGG--------SIPRRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLG 352
G LY VGG S+ K N +W AP+ R + V G +Y++G
Sbjct: 400 GLLYAVGGFDGSTGLSSVEAYNIKSN----EWFHVAPMNTRRSSVGVGVVGG--LLYAVG 453
Query: 353 GKT-LQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTK 411
G + V Y N WT ++ SGA LN ++Y +GG + L
Sbjct: 454 GYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL----- 508
Query: 412 PSRLIQCFDTETDKCHVKPYVLPFAGRMHAAVHKDLVFIVAEGD------SLVCYNPLLD 465
+ ++ +D T+ + L+++V D S+ YNP D
Sbjct: 509 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 568
Query: 466 SFT 468
+T
Sbjct: 569 KWT 571
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 117 bits (292), Expect = 3e-26
Identities = 99/382 (25%), Positives = 172/382 (45%), Gaps = 32/382 (8%)
Query: 41 SHSGRVAQGIMKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNR 100
+H G+ + +M ++L DV I E E + HR+VL+A S +F +MFT ++ E+ +
Sbjct: 31 AHMGKAFK-VMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAK 89
Query: 101 VIVLQDVSESVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQV 160
I ++DV L+DYIY +++ E +Q + + + QL + + C FL +
Sbjct: 90 KIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 149
Query: 161 GNCLQVMWLADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISDG---VPC 217
NCL + AD H+ +L A A+ H ++ EEFL L + +IS V
Sbjct: 150 TNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSS 209
Query: 218 SQNPTEAIEAWINFNKEEREAFAESLRTSLKEIGENVHIYLIGK----ESSRTHSLAVSL 273
+ EA+ +WIN+ KE R + ++ E+V + L+ + ++ +L +
Sbjct: 210 EEKVFEAVISWINYEKETR-------LEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNN 262
Query: 274 HCAEDDSISVSGQNSLCHQITAACKHGGD-----------LYVVGGSIPR--RMWKCNNA 320
+ +D I + L K+ + VVGG P+ R +C +
Sbjct: 263 NTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDF 322
Query: 321 TVD-WEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQ 379
D W+ A LP R + +V + G +Y++GG + +Y V D WT
Sbjct: 323 EEDRWDQIAELPSRRCRAGVVFMAGH--VYAVGGFNGSLRVRTVDVYDGVKDQ-WTSIAS 379
Query: 380 LEVAVSGAAGANLNGIIYLLGG 401
++ S A LN ++Y +GG
Sbjct: 380 MQERRSTLGAAVLNDLLYAVGG 401
Score = 42.0 bits (97), Expect = 0.001
Identities = 38/156 (24%), Positives = 69/156 (44%), Gaps = 18/156 (11%)
Query: 301 GDLYVVGG------SIPRRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGK 354
G LY VGG + + N AT +W + A + R + + G+ +Y+ GG
Sbjct: 441 GKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQ--LYATGGH 498
Query: 355 TLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSR 414
+ +V Y G N W + + + A +NG++Y++GG++ + +
Sbjct: 499 D-GPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLAS---- 553
Query: 415 LIQCFDTETDKCHVKPYVLPFAGRMHAAV---HKDL 447
++ ++ TDK + P + GR +A V HK L
Sbjct: 554 -VEYYNPVTDKWTLLPTNMS-TGRSYAGVAVIHKSL 587
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 116 bits (291), Expect = 4e-26
Identities = 112/489 (22%), Positives = 198/489 (40%), Gaps = 75/489 (15%)
Query: 35 YTFKDRSHSGRVAQGIMKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNL 94
Y F S++ V + L ++ LF DV + R F HR VL+A S +F +MF+ L
Sbjct: 21 YLFHKSSYADSVLTHL-NLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGL 79
Query: 95 KEAHNRVIVLQD-VSESVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRF 153
KE+ + + + + V +LL+DY Y V + E + + E DM + + + C+ F
Sbjct: 80 KESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEF 139
Query: 154 LARTVQVGNCLQVMWLADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISD 213
L + + NCL ++ L+D H +LY + ++ ++ E+FL LP ++ ++S
Sbjct: 140 LEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSS 199
Query: 214 GVPCSQNPTEAIEA---WINFNKEEREAFAESLRTSLK-------EIGENVHI-YLIGKE 262
+++ E+ WI+++ ++R + L +++ + ENV + LI K+
Sbjct: 200 EELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQ 259
Query: 263 SSRTHSLAVSLHC----AEDDSISVS----------------GQNSLCHQI--------- 293
+ ++ C ++D + S GQ +C ++
Sbjct: 260 RKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAKE 319
Query: 294 -------------TAACKHGGDLYVVGG-----SIPRRMWKCNNATVDWEWCAPLPRDRL 335
+AC G +Y+ GG + + +W + +W AP+ R
Sbjct: 320 IIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARF 379
Query: 336 QHTLVSVPGKDAIYSLGGKTLQDTLSNA--------VIYYRVGDNVWTETTQLEVAVSGA 387
H S K +Y +GG T A V +Y N WT L VS A
Sbjct: 380 GHG--SAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNA 437
Query: 388 AGANLNGIIYLLGGEENDLDFFTKPSRLIQCFDTETDKCHVKPYVLPFAGRMHAAVHKDL 447
A + ++ GG D K +QC+D ++ V P P R AA
Sbjct: 438 AVVSAKLKLFAFGGTSVSHDKLPK----VQCYDQCENRWTV-PATCPQPWRYTAAAVLGN 492
Query: 448 VFIVAEGDS 456
+ GD+
Sbjct: 493 QIFIMGGDT 501
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 115 bits (289), Expect = 8e-26
Identities = 104/450 (23%), Positives = 181/450 (40%), Gaps = 43/450 (9%)
Query: 49 GIMKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVS 108
G+M +++ DV + V+ R+ HR+VL+A S FF MFT+N+ E+ + + L+D
Sbjct: 32 GVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAE 91
Query: 109 ESVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMW 168
+ + LV++ Y + + + +Q + + ++ YQ+ + + C FL V NCL +
Sbjct: 92 PDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISV 151
Query: 169 LADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISDG---VPCSQNPTEAI 225
LA+ PEL A H ++ T+EFL L + +T +++ V +A
Sbjct: 152 LAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAA 211
Query: 226 EAWINFNKEEREAFAESLRTSLK-------EIGENVHIYLIGKESSRTHSLAVS-----L 273
W+ +++ R+ F + ++ + + V + +++ + +S L
Sbjct: 212 VRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHL 271
Query: 274 HCAEDDSISVSGQNSLCHQITAACKHGGDLYVVGGSIPRRMWKCNNATVDW-EWCAPLPR 332
ED V G KH + + GGS P+ N W + P +
Sbjct: 272 LSPEDREELVDGTR------PRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEK 325
Query: 333 DRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANL 392
R V + +Y LGG L + Y V + W A
Sbjct: 326 RR---DAACVFWDNVVYILGGSQLFPI--KRMDCYNVVKDSWYSKLGPPTPRDSLAACAA 380
Query: 393 NGIIYLLGGEENDLDFFTKPSRLIQCFDTETDKCHVKPYVLPFAGRMHAAVHKDLVFIVA 452
G IY GG E L +C+DT T+ H KP +L H V + + V
Sbjct: 381 EGKIYTSGGSE----VGNSALYLFECYDTRTESWHTKPSMLT-QRCSHGMVEANGLIYVC 435
Query: 453 EG-----------DSLVCYNPLLDSFTRLC 471
G +S Y+P +++T LC
Sbjct: 436 GGSLGNNVSGRVLNSCEVYDPATETWTELC 465
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 115 bits (288), Expect = 1e-25
Identities = 132/558 (23%), Positives = 230/558 (41%), Gaps = 96/558 (17%)
Query: 37 FKDRSHSGRVAQGIMKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKE 96
F D S + G+ L +E L DV + V+ +EF HR+VL+A S +FR+MF ++LKE
Sbjct: 49 FDDAGLSLILQNGLETLRMENAL-TDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKE 107
Query: 97 AHNRVIVLQDVSESVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLAR 156
+ + I+++ V L+DY Y + + +Q + E ++++Q + + C+ FL
Sbjct: 108 KYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTE 167
Query: 157 TVQVGNCLQVMWLADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDII-SDGV 215
+ NC+ ++ LAD HS L + + Q+ N+EEFL LP L I+ SD +
Sbjct: 168 ALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDL 227
Query: 216 PCSQNPT--EAIEAWINFNKEEREAF----AESLRTSLKE---IGENVHIYLIGKESSRT 266
++ E + +W+ ER E++R L + E V + ++
Sbjct: 228 YVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEV 287
Query: 267 HSL---AVSLHCAEDDSISVSGQNSLCHQITAACKHGGDLYVVGGSIPRRMWKCNNATVD 323
L A H + ++ IS + + H+ + ++GG + +D
Sbjct: 288 FPLLQEARMYHLSGNEIISERTKPRM-HEFQSEV-----FMIIGGCTKDERFVAEVTCLD 341
Query: 324 WEWCAPLPRDRL--------QHTLVS----------VPGKDAIYSLGGKTLQDTLSNAVI 365
PL R RL +H L S V K+ +Y GGK Q + V
Sbjct: 342 -----PLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQ----HDVW 392
Query: 366 YYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEE-----NDLDFF-------TKPS 413
Y N W + L + L G +Y++GG + N+++ + ++ +
Sbjct: 393 KYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAA 452
Query: 414 RLI-------------------------------QCFDTETDKCHVKPYVLPFAGRMHAA 442
L+ QC+D T+K +K + A ++A
Sbjct: 453 PLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAV 512
Query: 443 VHKDLVFIVAEG-DSLVCYNPLLDSFTRLCLPEAWSSAPSLWKIASCNGSIYVFRDRYKK 501
+D +++V +L Y+PL DS+ CL S + IA CN +Y+ R +K
Sbjct: 513 SFRDRIYVVGGAMRALYAYSPLEDSW---CLVTQLSHERASCGIAPCNNRLYITGGRDEK 569
Query: 502 GD--ANTYKLDPATSAVT 517
+ A DP +T
Sbjct: 570 NEVIATVLCWDPEAQKLT 587
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 114 bits (285), Expect = 2e-25
Identities = 111/498 (22%), Positives = 213/498 (42%), Gaps = 61/498 (12%)
Query: 59 LFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQD-VSESVFQLLVD 117
+F DVT+ R F HR VL+A S +F +MF+ L+E+ + + QD + V +LL+D
Sbjct: 44 MFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLD 103
Query: 118 YIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPE 177
+ Y + + E + + E DM Q + + + FL + + NCL +M L+D H
Sbjct: 104 FAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRR 163
Query: 178 LYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISDGVPCSQNPT---EAIEAWINFNKE 234
LY + H ++ +E+F L L D+IS +++ EAI W+ + E
Sbjct: 164 LYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLE 223
Query: 235 EREAFAESLRTSLKEIGENVHIYLIGKESSRTHSLAVSLHCAEDDSISVSGQNSLCHQ-- 292
R + L E+ +V + L+ + + + +L A++ + + + C
Sbjct: 224 PR-------KVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALRCKTRI 276
Query: 293 ------ITAAC----KHGGDLYVVGGS--IPRRMWKCNNATVDWEWCAPLPRDRLQHTLV 340
+T+ C K G L ++GG + ++++ ++ + A LP R + +
Sbjct: 277 LQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSAS 336
Query: 341 SVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLG 400
++ K +Y GG+ ++ +S V Y W++ + +A G A L +Y++G
Sbjct: 337 AIGCK--VYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVG 394
Query: 401 GEENDLDFF-TKPS---RLIQCFDTETDK----------------CHVKPYVLPFAGRMH 440
G + F PS + ++ +D +K K + F G
Sbjct: 395 GHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGG--- 451
Query: 441 AAVHKDLVFIVAEGDSLVCYNPLLDSFT-RLCLPEAWSSAPSLWKIASCNGSIYVFRDRY 499
++H+D+V + CY+P + +T + P+ W + A I++
Sbjct: 452 TSIHRDMV------SKVQCYDPSENRWTIKAECPQPWRYTAA----AVLGSQIFIMGGDT 501
Query: 500 KKGDANTYKLDPATSAVT 517
+ A+ Y+ D T+ T
Sbjct: 502 EFTAASAYRFDCETNQWT 519
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 113 bits (282), Expect = 5e-25
Identities = 99/385 (25%), Positives = 170/385 (44%), Gaps = 33/385 (8%)
Query: 42 HSGRVAQGIMKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRV 101
HS ++ QG+ L EL D+ + V + H++VL++ S +F++MFT NL E N
Sbjct: 17 HSEQLLQGLNLLRQHHEL-CDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSE 75
Query: 102 IVLQDVSESVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVG 161
+ Q + E+ Q +V+Y Y GTV + + ++ + +++ Q+ + +EC FL + G
Sbjct: 76 VEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPG 135
Query: 162 NCLQVMWLADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISD---GVPCS 218
NC+ + A+ + +LY AA + + TEEF L H L +I+S+ V
Sbjct: 136 NCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATE 195
Query: 219 QNPTEAIEAWINFNKEEREAFA----ESLRTSLKEIGENVHIY----LIGKESSRTHSLA 270
+ A+E+WI ++ +ER+ + S+R L + +Y LI + + H L
Sbjct: 196 ETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLN 255
Query: 271 VSLHCAEDDSISVSGQNSLCHQITAACKHGGDLYVVGGSIPRRMWKCNNATV-------D 323
+L +S Q L + A K L VGG ++ C ++
Sbjct: 256 EALKYHFMPEHRLSHQTVLMTRPRCAPKV---LCAVGGK--SGLFACLDSVEMYFPQNDS 310
Query: 324 WEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQ-------DTLSNAVIYYRVGDNVWTE 376
W APL R + + + K +Y +GG N+V + N WT
Sbjct: 311 WIGLAPLNIPRYEFGICVLDQK--VYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTS 368
Query: 377 TTQLEVAVSGAAGANLNGIIYLLGG 401
++ + S L G +Y LGG
Sbjct: 369 LERMNESRSTLGVVVLAGELYALGG 393
Score = 30.4 bits (67), Expect = 4.2
Identities = 27/110 (24%), Positives = 48/110 (43%), Gaps = 6/110 (5%)
Query: 295 AACKHGGDLYVVGGSIPRRM---WKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSL 351
AA G +Y +GG P M + + + WE A + R+ + + G I+ +
Sbjct: 427 AAAVLDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLG--FIFVV 484
Query: 352 GGKTLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGG 401
GG LS+ + Y N WT ++ +G A ++ +Y++GG
Sbjct: 485 GGHNGVSHLSS-IERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGG 533
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 112 bits (281), Expect = 6e-25
Identities = 91/380 (23%), Positives = 161/380 (42%), Gaps = 48/380 (12%)
Query: 49 GIMKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVS 108
G+M+ + DVT+ + +F HR+VL+A +F +MFT+++ E IV+Q +
Sbjct: 26 GVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMD 85
Query: 109 ESVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMW 168
S + L+++ Y+G + + + +Q + + QL S+ + C FL + NCL V
Sbjct: 86 PSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQ 145
Query: 169 LADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISD---GVPCSQNPTEAI 225
A+ LY AA H ++ +EEFL LP + +++S V + EA
Sbjct: 146 FAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAA 205
Query: 226 EAWINFNKEEREAFAESLRTSLKEIGENVHIYLIGKESSRTHSLAVSLHCAEDDSISVSG 285
AW+ +++E+R + L E+ N+ + L + +S +DD +
Sbjct: 206 LAWVRYDREQRGPY-------LPELLSNIRLPLCRPQ-------FLSDRVQQDDLV---- 247
Query: 286 QNSLCHQITAACKHGGDLYVVGGSIPRRMWKCNNATVDWEWCAPLPRDRLQ-HTLVSVPG 344
CH+ D +++ P LP R + S+ G
Sbjct: 248 --RCCHKCRDLVDEAKDYHLMPERRPH-----------------LPAFRTRPRCCTSIAG 288
Query: 345 KDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEEN 404
IY++GG N V + N W + A S A +NG++Y +GG +
Sbjct: 289 --LIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDG 346
Query: 405 DLDFFTKPSRLIQCFDTETD 424
L T ++ ++ ETD
Sbjct: 347 QLRLST-----VEAYNPETD 361
Score = 36.6 bits (83), Expect = 0.059
Identities = 41/187 (21%), Positives = 72/187 (38%), Gaps = 12/187 (6%)
Query: 242 SLRTSLKEIGENVHIYLIGKESSRTHSLAVSLHCAEDDSISVSGQNSLCHQITAACKHGG 301
S R+++ + + IY+ G + +V + E D +V S G
Sbjct: 371 SKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEG 430
Query: 302 DLYVVGGSIPRRMWKC----NNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQ 357
+YV GG +++ N+ T W A + R +H S+ K ++ GG
Sbjct: 431 RIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSK--MFVCGGYDGS 488
Query: 358 DTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQ 417
LS A +Y V D W + S + G +Y +GG + + + ++
Sbjct: 489 GFLSIAEMYSSVADQ-WCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSS-----VE 542
Query: 418 CFDTETD 424
+D ETD
Sbjct: 543 MYDPETD 549
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 112 bits (279), Expect = 1e-24
Identities = 102/442 (23%), Positives = 177/442 (40%), Gaps = 43/442 (9%)
Query: 57 EELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLLV 116
++ DV + V+ R+ HR+VL+A S FF MFT+N+ E+ + + L+D + + LV
Sbjct: 18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLV 77
Query: 117 DYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDP 176
++ Y + + + +Q + + ++ YQ+ + + C FL V NCL + LA+ P
Sbjct: 78 EFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCP 137
Query: 177 ELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISDG---VPCSQNPTEAIEAWINFNK 233
EL A H ++ T+EFL L + +T +++ V +A W+ +++
Sbjct: 138 ELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 197
Query: 234 EEREAFAESLRTSLK-------EIGENVHIYLIGKESSRTHSLAVS-----LHCAEDDSI 281
R+ F + ++ + + V + +++ + +S L ED
Sbjct: 198 PNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREE 257
Query: 282 SVSGQNSLCHQITAACKHGGDLYVVGGSIPRRMWKCNNATVDW-EWCAPLPRDRLQHTLV 340
V G KH + + GGS P+ N W + P + R
Sbjct: 258 LVDGTR------PRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRR---DAA 308
Query: 341 SVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLG 400
V + +Y LGG L + Y V + W A G IY G
Sbjct: 309 CVFWDNVVYILGGSQLFPI--KRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSG 366
Query: 401 GEENDLDFFTKPSRLIQCFDTETDKCHVKPYVLPFAGRMHAAVHKDLVFIVAEG------ 454
G E L +C+DT T+ H KP +L H V + + V G
Sbjct: 367 GSE----VGNSALYLFECYDTRTESWHTKPSMLT-QRCSHGMVEANGLIYVCGGSLGNNV 421
Query: 455 -----DSLVCYNPLLDSFTRLC 471
+S Y+P +++T LC
Sbjct: 422 SGRVLNSCEVYDPATETWTELC 443
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 110 bits (274), Expect = 4e-24
Identities = 94/376 (25%), Positives = 166/376 (44%), Gaps = 32/376 (8%)
Query: 50 IMKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSE 109
++ L + DV + V ++ HR++LSA S +FR+MFT L E+ +V++D+ E
Sbjct: 57 VINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDE 116
Query: 110 SVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWL 169
+LL+D+ Y + + +Q + + + QL + E C FL R + NCL +
Sbjct: 117 RAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAF 176
Query: 170 ADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISD---GVPCSQNPTEAIE 226
AD HS EL A + + ++ +EEF+ LP L DIIS V + A+
Sbjct: 177 ADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVM 236
Query: 227 AWINFNKEEREAFAESLRTSLKEIGENVHI------YLIGKESS----RTHSLAVSLHCA 276
AW+ ++ +ER R L ++ ++V + +L+G S ++ L
Sbjct: 237 AWVKYSIQER-------RPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDE 289
Query: 277 EDDSISVSGQNSLCH----QITAACKHGGDLYVVG----GSIPRRMWKCNNATVDWEWCA 328
+ + + + L + + G L+ VG G + + + T +W A
Sbjct: 290 AKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVA 349
Query: 329 PLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVW-TETTQLEVAVSGA 387
+ + R VSV D +Y++GG L N+V Y N W ++ +
Sbjct: 350 SMSKRRC-GVGVSVL-DDLLYAVGGHDGSSYL-NSVERYDPKTNQWSSDVAPTSTCRTSV 406
Query: 388 AGANLNGIIYLLGGEE 403
A L G +Y +GG++
Sbjct: 407 GVAVLGGFLYAVGGQD 422
Score = 45.1 bits (105), Expect = 2e-04
Identities = 43/180 (23%), Positives = 77/180 (42%), Gaps = 29/180 (16%)
Query: 348 IYSLGGKTLQDTLS--NAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEEND 405
+Y++GG QD +S N V Y +N WT + G A A L G +Y +GG +
Sbjct: 415 LYAVGG---QDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDG- 470
Query: 406 LDFFTKPSRLIQCFDTETDKCHVKPYVLPFAGR---MHAAVHKDLVFIVAEGD------S 456
T P ++ ++ + ++ H + P R + AV++D+++ V D S
Sbjct: 471 ----TSPLNTVERYNPQENRWHT---IAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSS 523
Query: 457 LVCYNPLLDSFTRLCLPEAWSSA-------PSLWKIASCNGSIYVFRDRYKKGDANTYKL 509
YNP + ++ + + S L + +G+ Y+ DANT++L
Sbjct: 524 AERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRL 583
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 109 bits (273), Expect = 5e-24
Identities = 98/419 (23%), Positives = 171/419 (40%), Gaps = 58/419 (13%)
Query: 15 ASMESPEEPGASMDENYFVNYTFKDRSHSGRVAQGIMKLCLEEELFADVTISVE-----G 69
AS E E S N +YT +D + + A GIM + DVT+ V+
Sbjct: 34 ASTECKAEVTPSQHGNRTFSYTLEDHT---KQAFGIMNELRLSQQLCDVTLQVKYQDAPA 90
Query: 70 REFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLLVDYIYHGTVKLRAE 129
+F H++VL++ S F++MFT+ L+E V+ ++ + V + L+++ Y ++ + +
Sbjct: 91 AQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEK 150
Query: 130 ELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPELYTAAKHCAKTH 189
+ + + MYQ+ S+ CS FL + + N + + A++ EL+ A+ H
Sbjct: 151 CVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMH 210
Query: 190 LAQLQNTEEFLHLPHRLLTDIISD---GVPCSQNPTEAIEAWINFNKEEREAFAESLRTS 246
++ EEF +L H L +IS V C A W+ ++ E+R + ++L +
Sbjct: 211 FGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRA 270
Query: 247 LKEIGENVHIYLIGKESSRTHSLAVSLHCAEDDSISVSGQNSLCHQITAACKHGGDLYVV 306
+ R HSL + + + +S C L+
Sbjct: 271 V-----------------RCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHK- 312
Query: 307 GGSIPRRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIY 366
P ++ C V RL IY+ GG Q + +
Sbjct: 313 ----PTQVMPCRAPKV----------GRL------------IYTAGGYFRQSL--SYLEA 344
Query: 367 YRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQCFDTETDK 425
Y D W L+V SG AG + G++Y +GG N D T S L C++ T++
Sbjct: 345 YNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSAL-DCYNPMTNQ 402
Score = 40.0 bits (92), Expect = 0.005
Identities = 44/183 (24%), Positives = 78/183 (42%), Gaps = 24/183 (13%)
Query: 301 GDLYVVGGSIP----RRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTL 356
G +Y VGGS + + +W AP+ R+ + + +Y++GG
Sbjct: 423 GHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVL--NRLLYAVGGFDG 480
Query: 357 QDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRLI 416
+ L++A YY N W T + SGA L+ IY GG + +
Sbjct: 481 TNRLNSAECYYPER-NEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQ-----DQLNSV 534
Query: 417 QCFDTETDKCHVKPYVLPFAGRMHA---AVHKDLVFIVA--EG----DSLVCYNPLLDSF 467
+ +D ET+ +V P R A VH+ ++++ +G DS+ CY+P D++
Sbjct: 535 ERYDVETE---TWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591
Query: 468 TRL 470
+ +
Sbjct: 592 SEV 594
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 109 bits (273), Expect = 5e-24
Identities = 98/419 (23%), Positives = 171/419 (40%), Gaps = 58/419 (13%)
Query: 15 ASMESPEEPGASMDENYFVNYTFKDRSHSGRVAQGIMKLCLEEELFADVTISVE-----G 69
AS E E S N +YT +D + + A GIM + DVT+ V+
Sbjct: 34 ASTECKAEVTPSQHGNRTFSYTLEDHT---KQAFGIMNELRLSQQLCDVTLQVKYQDAPA 90
Query: 70 REFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLLVDYIYHGTVKLRAE 129
+F H++VL++ S F++MFT+ L+E V+ ++ + V + L+++ Y ++ + +
Sbjct: 91 AQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEK 150
Query: 130 ELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPELYTAAKHCAKTH 189
+ + + MYQ+ S+ CS FL + + N + + A++ EL+ A+ H
Sbjct: 151 CVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMH 210
Query: 190 LAQLQNTEEFLHLPHRLLTDIISD---GVPCSQNPTEAIEAWINFNKEEREAFAESLRTS 246
++ EEF +L H L +IS V C A W+ ++ E+R + ++L +
Sbjct: 211 FGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRA 270
Query: 247 LKEIGENVHIYLIGKESSRTHSLAVSLHCAEDDSISVSGQNSLCHQITAACKHGGDLYVV 306
+ R HSL + + + +S C L+
Sbjct: 271 V-----------------RCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHK- 312
Query: 307 GGSIPRRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIY 366
P ++ C V RL IY+ GG Q + +
Sbjct: 313 ----PTQVMPCRAPKV----------GRL------------IYTAGGYFRQSL--SYLEA 344
Query: 367 YRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQCFDTETDK 425
Y D W L+V SG AG + G++Y +GG N D T S L C++ T++
Sbjct: 345 YNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSAL-DCYNPMTNQ 402
Score = 40.0 bits (92), Expect = 0.005
Identities = 44/183 (24%), Positives = 78/183 (42%), Gaps = 24/183 (13%)
Query: 301 GDLYVVGGSIP----RRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTL 356
G +Y VGGS + + +W AP+ R+ + + +Y++GG
Sbjct: 423 GHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVL--NRLLYAVGGFDG 480
Query: 357 QDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRLI 416
+ L++A YY N W T + SGA L+ IY GG + +
Sbjct: 481 TNRLNSAECYYPER-NEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQ-----DQLNSV 534
Query: 417 QCFDTETDKCHVKPYVLPFAGRMHA---AVHKDLVFIVA--EG----DSLVCYNPLLDSF 467
+ +D ET+ +V P R A VH+ ++++ +G DS+ CY+P D++
Sbjct: 535 ERYDVETE---TWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591
Query: 468 TRL 470
+ +
Sbjct: 592 SEV 594
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 109 bits (272), Expect = 7e-24
Identities = 100/358 (27%), Positives = 167/358 (46%), Gaps = 23/358 (6%)
Query: 62 DVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLLVDYIYH 121
DVT+ VE ++F HR+VL+A S +F +MFTS L E + +Q ++ S ++L+D++Y
Sbjct: 34 DVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTASTMEILLDFVYT 93
Query: 122 GTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPELYTA 181
TV + E +QE+ + + QL + + C FL + NCL + A+ H+ +L A
Sbjct: 94 ETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQA 153
Query: 182 AKHCAKTHLAQLQNTEEFLHLPHRLLTDIIS-DGVPC-SQNPT-EAIEAWINFNKEEREA 238
A+ ++ H ++ EEF+ L + +I D + S+ P EA+ W+ K+ERE
Sbjct: 154 AEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKERE- 212
Query: 239 FAESLRTSLKEIGENVHI-YLIGKESSRTHSLAVSLHCAE--DDSISVSGQNSLCHQI-- 293
ESL L+ + + I + SL C + D++ + L Q+
Sbjct: 213 --ESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLRPELRSQMQG 270
Query: 294 -TAACKHGGD--LYVVGGSIPRR-----MWKCNNATVDWEWCAPLPRDRLQHTLVSVPGK 345
+ G + L VVGG ++ + K + T +W + + R R + SV
Sbjct: 271 PRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKR--RYVASVSLH 328
Query: 346 DAIYSLGGKTLQDTLSN--AVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGG 401
D IY +GG + LS+ + Y D VW + V A L +IY+ GG
Sbjct: 329 DRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGG 386
Score = 54.3 bits (129), Expect = 3e-07
Identities = 95/389 (24%), Positives = 161/389 (41%), Gaps = 59/389 (15%)
Query: 106 DVSESVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFE----ECSRFLARTVQVG 161
D E VF+ +++++ H K R E L + + M LT + + F+ ++Q
Sbjct: 191 DSEEPVFEAVINWVKHAK-KEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQ-- 247
Query: 162 NCLQVMWLADR-HSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISDGVPCSQN 220
C ++ A + H PEL + + A+L E L + G Q+
Sbjct: 248 -CRDLVDEAKKFHLRPELRSQMQ--GPRTRARLGANEVLL----------VVGGFGSQQS 294
Query: 221 PTEAIEAWINFNKEEREAFAESL---RTSLKEIGENVHIYLIGKESSRTHSLAVSL--HC 275
P + +E + K + +F S+ R + + + IY+IG R+ +V +
Sbjct: 295 PIDVVEKYDP--KTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYT 352
Query: 276 AEDDSI--SVSGQNSLCHQITAACKHGGDLYVVGGSIPRR----MWKCNNATVDWEWCAP 329
A++D + SV+ N + + A G +YV GG R M + + W
Sbjct: 353 ADEDGVWYSVAPMN-VRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGD 411
Query: 330 LPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAG 389
+ R LV G IY LGG + L N+V Y WT T + SGA
Sbjct: 412 MQTAREGAGLVVASG--VIYCLGGYDGLNIL-NSVEKYDPHTGHWTNVTPMATKRSGAGV 468
Query: 390 ANLNGIIYLLGGEENDLDFFTKPSRLIQCFDTETD-----------KCHVKPYVLPFAGR 438
A LN IY++GG + T ++ ++ TD +C+V VL GR
Sbjct: 469 ALLNDHIYVVGGFDG-----TAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVL--RGR 521
Query: 439 MHAAVHKDLVFIVAEGDSLVCYNPLLDSF 467
++A D +++ S+ CY+P++DS+
Sbjct: 522 LYAIAGYDGNSLLS---SIECYDPIIDSW 547
>gi|11545731 gigaxonin [Homo sapiens]
Length = 597
Score = 105 bits (262), Expect = 1e-22
Identities = 105/457 (22%), Positives = 194/457 (42%), Gaps = 37/457 (8%)
Query: 39 DRSHSGRVAQGIMKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSN--LKE 96
D H+ R+ + + EE F D + ++G E + + +L+A S + R+ N +
Sbjct: 9 DPQHAARLLRALSSF-REESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDD 67
Query: 97 AHNRVIVLQDVSESVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLAR 156
I L+ +S V + ++DYI+ G ++L + +Q++ + +D+ LT L C FL
Sbjct: 68 GSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEG 127
Query: 157 TVQVGNCLQVMWLADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIIS---D 213
+ NC+ + A + ++ A +TH + +TEEFL L + L ++IS
Sbjct: 128 CIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKL 187
Query: 214 GVPCSQNPTEAIEAWINFNKEEREAFAESLRTSLKEIGENVHIYLIGKESSRTHSLAVSL 273
V + EA+ WI + E R+ + + ++L G + YL +E L +
Sbjct: 188 NVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLD-SSYL--REQMLNEPLVREI 244
Query: 274 HCAEDDSISVSGQNSLCHQITAACKHGG---DLYVVGGS-----IPRRMWKCNNATVD-- 323
E +I +S Q + A K G + VGG P +C D
Sbjct: 245 -VKECSNIPLS-QPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYDPN 302
Query: 324 ---WEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQL 380
W APL R+ H ++S G ++ GG+ ++ Y N WT +
Sbjct: 303 RQLWIELAPLSMPRINHGVLSAEG--FLFVFGGQDENKQTLSSGEKYDPDANTWTALPPM 360
Query: 381 EVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQCFDTETDKCHVKPYVLPFAGRMH 440
A ++G++Y+LGGE+ + + + ++C+D + +P +
Sbjct: 361 NEARHNFGIVEIDGMLYILGGEDGEKELIS-----MECYDIYSKTWTKQPDLTMVRKIGC 415
Query: 441 AAVHKDLVFIVAEG------DSLVCYNPLLDSFTRLC 471
A K ++ + G +S+ CY+P +T +C
Sbjct: 416 YAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAIC 452
>gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Homo
sapiens]
Length = 606
Score = 105 bits (261), Expect = 1e-22
Identities = 57/200 (28%), Positives = 103/200 (51%), Gaps = 3/200 (1%)
Query: 40 RSHSGRVAQGIMKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHN 99
R + + Q +K L+E+ F D T+ + HRL+LSA S +FR F S + EA
Sbjct: 12 RLYQSTLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKK 71
Query: 100 RVIVLQDVSESVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQ 159
+ +VL +V ++ L++ Y+Y ++ L +Q+I+ ++ +Q+ S+F C +L + +
Sbjct: 72 KEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLA 131
Query: 160 VGNCLQVMWLADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHL-PHRLLTDIISDGVPCS 218
GNCL ++ L P L +A+ Q+ E+F+ L P L++ I +D +
Sbjct: 132 PGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVE 191
Query: 219 QNPT--EAIEAWINFNKEER 236
+ EA+ W+ +KE R
Sbjct: 192 KEEAVFEAVMKWVRTDKENR 211
Score = 37.0 bits (84), Expect = 0.045
Identities = 34/128 (26%), Positives = 51/128 (39%), Gaps = 20/128 (15%)
Query: 281 ISVSGQNSLCHQITAACKHGGDLYVVGGSIPRRMWKCNNATV-------DWEWCAPLPRD 333
I V G N + H+ G +Y +GG + KC N DW+ AP+
Sbjct: 435 IKVYGHNVISHK--------GMIYCLGGKTDDK--KCTNRVFIFNPKKGDWKDLAPMKIP 484
Query: 334 RLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLN 393
R + GK I G +D LS +V + + N W T+ S + +L
Sbjct: 485 RSMFGVAVHKGKIVI---AGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLA 541
Query: 394 GIIYLLGG 401
G +Y +GG
Sbjct: 542 GSLYAIGG 549
Score = 34.7 bits (78), Expect = 0.22
Identities = 29/105 (27%), Positives = 41/105 (39%), Gaps = 7/105 (6%)
Query: 324 WEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVA 383
W LP H ++S G IY LGGKT +N V + W + +++
Sbjct: 427 WNEVKKLPIKVYGHNVISHKGM--IYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIP 484
Query: 384 VSGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQCFDTETDKCHV 428
S A G I + GG D S ++ FD T+K V
Sbjct: 485 RSMFGVAVHKGKIVIAGGVTED-----GLSASVEAFDLTTNKWDV 524
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 104 bits (260), Expect = 2e-22
Identities = 131/518 (25%), Positives = 220/518 (42%), Gaps = 48/518 (9%)
Query: 37 FKDRSHSGRVAQGIMKLCLEEELFADVTISVEG-REFQLHRLVLSAQSCFFRSMFTSNLK 95
F D +H+ + +G+ +L E + F DVT+ G R+F HR VL+A S +FR+MF L+
Sbjct: 12 FSDPAHALSLLRGLSQLRAERK-FLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLR 70
Query: 96 EAHNRVIVLQDVSESVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLA 155
E+ + L V + QLL+D+ Y G V + + + + +D+ Q ++ E C FL
Sbjct: 71 ESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
Query: 156 RTVQVGNCLQVMWLADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLP-HRLLTDIISDG 214
+ + + NCL + A+ S L +AA+ H+ +L E+ LP RLL + DG
Sbjct: 131 QQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDG 189
Query: 215 --VPCSQNPTEAIEAWINFNKEEREAFAESLRTSLKEIGENVHIYLIGKES-----SRTH 267
VP + + W+ + R A L +++ + YL+ +R
Sbjct: 190 LCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVR-LPFVRRFYLLAHVEAEPLVARCP 248
Query: 268 SLAVSLHCAEDDSISVSGQNSL--CHQITAACKHG-GDLYVVGGSIPRRMWKC------N 318
L A D + ++ C ++ G ++ V+ G + + N
Sbjct: 249 PCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYN 308
Query: 319 NATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETT 378
T W + A P D L V + IY GG L + V Y N W E
Sbjct: 309 PQTGQWRYLAEFP-DHLGGGYSIVALGNDIYVTGGSD-GSRLYDCVWRYNSSVNEWAEVA 366
Query: 379 QLEVAVSGAAGANLNGIIYLLGGEEND-LDFFTKPSRLIQCFDTETDKCHVKPYVLPFAG 437
+ A + + L+G++Y++ + + D T +Q D C G
Sbjct: 367 PMLKAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCS----TTACRG 422
Query: 438 RMHAAVHKDLVFIVAEGDSLV--CYNPLLDSFTRL-C--LPEAWSSAPSLWKIASCNGSI 492
R++A + +A +++V CY+P D ++ + C LP WS AP K A+ NG +
Sbjct: 423 RLYA------IGSLAGKETMVMQCYDPDTDLWSLVDCGQLP-PWSFAP---KTATLNGLM 472
Query: 493 YVFRDRYKKGDA-----NTYKLDPATSAVTVTRGIKVL 525
Y RD + D N + P+ + V V + VL
Sbjct: 473 YFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVL 510
Score = 42.0 bits (97), Expect = 0.001
Identities = 56/242 (23%), Positives = 92/242 (38%), Gaps = 56/242 (23%)
Query: 300 GGDLYVVGGSIPRRM----WKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKT 355
G D+YV GGS R+ W+ N++ +W AP+ + R H+ + G
Sbjct: 334 GNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDG----------L 383
Query: 356 LQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRL 415
L +++ Y + W + + + G +Y +G K + +
Sbjct: 384 LYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIG------SLAGKETMV 437
Query: 416 IQCFDTETD-----KCHVKPYVLPFAGRMHAAVHKDLVFIVAEGDSLV-CYNPLLDSFTR 469
+QC+D +TD C P P++ A L++ V + + V YNP TR
Sbjct: 438 MQCYDPDTDLWSLVDCGQLP---PWSFAPKTATLNGLMYFVRDDSAEVDVYNP-----TR 489
Query: 470 LCLPEAWSSAPSL------WKIASCNGSIYVFRDRYKKGDANTYKL-------DPATSAV 516
W PS+ +A G +YV G NT++L DP T A
Sbjct: 490 ----NEWDKIPSMNQVHVGGSLAVLGGKLYV-----SGGYDNTFELSDVVEAYDPETRAW 540
Query: 517 TV 518
+V
Sbjct: 541 SV 542
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 103 bits (257), Expect = 4e-22
Identities = 88/369 (23%), Positives = 161/369 (43%), Gaps = 42/369 (11%)
Query: 60 FADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLLVDYI 119
F DV + V F+ HRLVL+A S +F ++FT +KE+ V+ + + +FQ+L+D+I
Sbjct: 36 FCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFI 95
Query: 120 YHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPELY 179
Y G V + +QE+ +DM QLT + C FL + NC+ + +++ + +L
Sbjct: 96 YTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLL 155
Query: 180 TAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISDGVPCSQNPTEAIEAWINFNKEEREAF 239
+++ H ++ + EEFL L L I+ ++ +IE +E + F
Sbjct: 156 EFSENYIHVHFLEVHSGEEFLALTKDQLIKIL-------RSEELSIE-------DEYQVF 201
Query: 240 AESLRTSLKEIGENVHIYLIGKESSR-----THSLAVSLHCAEDDSISVSGQNSLCHQIT 294
+++ LK++G+ + + R L + D ++ V+ Q +L +
Sbjct: 202 LAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQ-TLLKEYC 260
Query: 295 AACKHGGDLYVVGGSIPRRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGK 354
CK P+ C+ + PR + + L +V G + GG+
Sbjct: 261 EVCKS-----------PKENKFCSFL----QTSKVRPRKKARKYLYAVGGYTRLQ--GGR 303
Query: 355 TLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSR 414
+ V + WT + L A SG L G++Y +GGE++ + F
Sbjct: 304 WSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIF-----D 358
Query: 415 LIQCFDTET 423
+C+D T
Sbjct: 359 CTECYDPVT 367
Score = 46.6 bits (109), Expect = 6e-05
Identities = 34/137 (24%), Positives = 60/137 (43%), Gaps = 7/137 (5%)
Query: 277 EDDSISVSGQNSLCHQITAACKHGGDLYVVGG----SIPRRMWKCNNATVDWEWCAPLPR 332
+++ V G ++ C+ G +YV+GG I R ++ + + W +PLP
Sbjct: 413 DENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDP-LSKRW-SPLPP 470
Query: 333 DRLQHTLVSVPG-KDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGAN 391
+ + V D IYS+GG + V Y + W E ++V +G
Sbjct: 471 MGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVA 530
Query: 392 LNGIIYLLGGEENDLDF 408
+NG++Y+ GG + DF
Sbjct: 531 VNGLLYVSGGRSSSHDF 547
Score = 35.8 bits (81), Expect = 0.10
Identities = 27/110 (24%), Positives = 46/110 (41%), Gaps = 7/110 (6%)
Query: 300 GGDLYVVGGSIPRRMWKCNNA----TVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKT 355
GG +Y +GG ++ C T W A + R + G AIY+LGG
Sbjct: 342 GGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYG--AIYALGGWV 399
Query: 356 LQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEEND 405
+ + N + + +N W + V+ + G+IY++GG N+
Sbjct: 400 GAE-IGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNE 448
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 103 bits (257), Expect = 4e-22
Identities = 88/369 (23%), Positives = 161/369 (43%), Gaps = 42/369 (11%)
Query: 60 FADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLLVDYI 119
F DV + V F+ HRLVL+A S +F ++FT +KE+ V+ + + +FQ+L+D+I
Sbjct: 36 FCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFI 95
Query: 120 YHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPELY 179
Y G V + +QE+ +DM QLT + C FL + NC+ + +++ + +L
Sbjct: 96 YTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLL 155
Query: 180 TAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISDGVPCSQNPTEAIEAWINFNKEEREAF 239
+++ H ++ + EEFL L L I+ ++ +IE +E + F
Sbjct: 156 EFSENYIHVHFLEVHSGEEFLALTKDQLIKIL-------RSEELSIE-------DEYQVF 201
Query: 240 AESLRTSLKEIGENVHIYLIGKESSR-----THSLAVSLHCAEDDSISVSGQNSLCHQIT 294
+++ LK++G+ + + R L + D ++ V+ Q +L +
Sbjct: 202 LAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQ-TLLKEYC 260
Query: 295 AACKHGGDLYVVGGSIPRRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGK 354
CK P+ C+ + PR + + L +V G + GG+
Sbjct: 261 EVCKS-----------PKENKFCSFL----QTSKVRPRKKARKYLYAVGGYTRLQ--GGR 303
Query: 355 TLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSR 414
+ V + WT + L A SG L G++Y +GGE++ + F
Sbjct: 304 WSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIF-----D 358
Query: 415 LIQCFDTET 423
+C+D T
Sbjct: 359 CTECYDPVT 367
Score = 47.8 bits (112), Expect = 3e-05
Identities = 35/148 (23%), Positives = 63/148 (42%), Gaps = 7/148 (4%)
Query: 277 EDDSISVSGQNSLCHQITAACKHGGDLYVVGG----SIPRRMWKCNNATVDWEWCAPLPR 332
+++ V G ++ C+ G +YV+GG I R ++ + + W +PLP
Sbjct: 413 DENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDP-LSKRW-SPLPP 470
Query: 333 DRLQHTLVSVPG-KDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGAN 391
+ + V D IYS+GG + V Y + W E ++V +G
Sbjct: 471 MGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVA 530
Query: 392 LNGIIYLLGGEENDLDFFTKPSRLIQCF 419
+NG++Y+ GG + DF + + F
Sbjct: 531 VNGLLYVSGGRSSSHDFLAPDTHRYEVF 558
Score = 35.8 bits (81), Expect = 0.10
Identities = 27/110 (24%), Positives = 46/110 (41%), Gaps = 7/110 (6%)
Query: 300 GGDLYVVGGSIPRRMWKCNNA----TVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKT 355
GG +Y +GG ++ C T W A + R + G AIY+LGG
Sbjct: 342 GGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYG--AIYALGGWV 399
Query: 356 LQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEEND 405
+ + N + + +N W + V+ + G+IY++GG N+
Sbjct: 400 GAE-IGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNE 448
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 103 bits (257), Expect = 4e-22
Identities = 87/369 (23%), Positives = 152/369 (41%), Gaps = 24/369 (6%)
Query: 51 MKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSES 110
M+ L+E+ DV + HRLVLSA S +F +MFT+++ EA + ++ V +
Sbjct: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
Query: 111 VFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLA 170
LV Y Y G ++L+ + ++ + + + QLT + + CS FL + + NCL +
Sbjct: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
Query: 171 DRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISD---GVPCSQNPTEAIEA 227
D EL A H ++ +EFL LP ++ ++ VP + A+
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
Query: 228 WINFNKEEREAFAESLRT---------SLKEIGENVHIYLIGKESSRTHSLAVSLHCAED 278
W+ + + R+ L + L E ++ E + A+ H +
Sbjct: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPE 411
Query: 279 DSISVSGQNSLCHQITAACKHGGDLYVVGGSIPRR----MWKCNNATVDWEWCAPLPRDR 334
+ + + T G LY VGG + + K + T W + R
Sbjct: 412 RRSMMQSPRTKPRKSTV-----GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRR 466
Query: 335 LQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNG 394
LQ + + K +Y +GG+ TL+ + VG +WT + G A L G
Sbjct: 467 LQFGVAVIDNK--LYVVGGRDGLKTLNTVECFNPVG-KIWTVMPPMSTHRHGLGVATLEG 523
Query: 395 IIYLLGGEE 403
+Y +GG +
Sbjct: 524 PMYAVGGHD 532
Score = 41.2 bits (95), Expect = 0.002
Identities = 45/189 (23%), Positives = 71/189 (37%), Gaps = 18/189 (9%)
Query: 301 GDLYVVGGSIPRRMWKCNNATVDWE-----WCAPLPRDRLQHTLVSVPGKDAIYSLGGKT 355
G +Y VGG W N W+ W + T+ V + +Y++GG+
Sbjct: 523 GPMYAVGG---HDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRD 579
Query: 356 LQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRL 415
L + + Y+ N W+ + G A NG +Y++GG +D SRL
Sbjct: 580 GSSCLKS-MEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGG--HDAPASNHCSRL 636
Query: 416 IQCFDTETDKCHVKPYVLPFAGRMHAAVHKDLVFIVAEGDSLVCYNPLLDSFTRLCLPEA 475
C + K V P +V +D V + GD L D T L E+
Sbjct: 637 SDCVERYDPKGDSWSTVAPL------SVPRDAVAVCPLGDKLYVVGG-YDGHTYLNTVES 689
Query: 476 WSSAPSLWK 484
+ + + WK
Sbjct: 690 YDAQRNEWK 698
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 103 bits (257), Expect = 4e-22
Identities = 87/369 (23%), Positives = 152/369 (41%), Gaps = 24/369 (6%)
Query: 51 MKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSES 110
M+ L+E+ DV + HRLVLSA S +F +MFT+++ EA + ++ V +
Sbjct: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
Query: 111 VFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLA 170
LV Y Y G ++L+ + ++ + + + QLT + + CS FL + + NCL +
Sbjct: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
Query: 171 DRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISD---GVPCSQNPTEAIEA 227
D EL A H ++ +EFL LP ++ ++ VP + A+
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
Query: 228 WINFNKEEREAFAESLRT---------SLKEIGENVHIYLIGKESSRTHSLAVSLHCAED 278
W+ + + R+ L + L E ++ E + A+ H +
Sbjct: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPE 411
Query: 279 DSISVSGQNSLCHQITAACKHGGDLYVVGGSIPRR----MWKCNNATVDWEWCAPLPRDR 334
+ + + T G LY VGG + + K + T W + R
Sbjct: 412 RRSMMQSPRTKPRKSTV-----GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRR 466
Query: 335 LQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNG 394
LQ + + K +Y +GG+ TL+ + VG +WT + G A L G
Sbjct: 467 LQFGVAVIDNK--LYVVGGRDGLKTLNTVECFNPVG-KIWTVMPPMSTHRHGLGVATLEG 523
Query: 395 IIYLLGGEE 403
+Y +GG +
Sbjct: 524 PMYAVGGHD 532
Score = 41.2 bits (95), Expect = 0.002
Identities = 45/189 (23%), Positives = 71/189 (37%), Gaps = 18/189 (9%)
Query: 301 GDLYVVGGSIPRRMWKCNNATVDWE-----WCAPLPRDRLQHTLVSVPGKDAIYSLGGKT 355
G +Y VGG W N W+ W + T+ V + +Y++GG+
Sbjct: 523 GPMYAVGG---HDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRD 579
Query: 356 LQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRL 415
L + + Y+ N W+ + G A NG +Y++GG +D SRL
Sbjct: 580 GSSCLKS-MEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGG--HDAPASNHCSRL 636
Query: 416 IQCFDTETDKCHVKPYVLPFAGRMHAAVHKDLVFIVAEGDSLVCYNPLLDSFTRLCLPEA 475
C + K V P +V +D V + GD L D T L E+
Sbjct: 637 SDCVERYDPKGDSWSTVAPL------SVPRDAVAVCPLGDKLYVVGG-YDGHTYLNTVES 689
Query: 476 WSSAPSLWK 484
+ + + WK
Sbjct: 690 YDAQRNEWK 698
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 103 bits (256), Expect = 5e-22
Identities = 90/394 (22%), Positives = 162/394 (41%), Gaps = 34/394 (8%)
Query: 29 ENYFVNYTFKDRSHSGRVAQGIMKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRS 88
E + V + K H VA M+ + L D+ + V +E + H++VL++ S +F +
Sbjct: 63 EGHSVAHNSKRHYHDAFVAMSRMR---QRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHA 119
Query: 89 MFTSNLKEAHNRVIVLQDVSESVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFE 148
MFT+ + E+ + L D+ LV + Y + + +Q + + + QL + +
Sbjct: 120 MFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRD 179
Query: 149 ECSRFLARTVQVGNCLQVMWLADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLT 208
C +FL + NCL + AD HS +L AA H + TEEF+ LP + +
Sbjct: 180 ACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVL 239
Query: 209 DIISD---GVPCSQNPTEAIEAWINFNKEEREAFAESLRTSLKEIGENVHIYLIGKESSR 265
+++S VP + A+ +W+ + + R R + + + V + L+ ++
Sbjct: 240 ELVSSDSLNVPSEEEVYRAVLSWVKHDVDAR-------RQHVPRLMKCVRLPLLSRDFLL 292
Query: 266 THSLAVSLHCAEDDSISVSGQNSLCHQI-------------TAACKHGGD-LYVVGG--- 308
H A SL D + + H + C+ G L+ VGG
Sbjct: 293 GHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSL 352
Query: 309 -SIPRRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYY 367
+I + T W A + R + + +V + +Y++GG L+ Y
Sbjct: 353 FAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNR--LYAVGGYDGTSDLATVESYD 410
Query: 368 RVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGG 401
V N W + S A L+G++Y GG
Sbjct: 411 PV-TNTWQPEVSMGTRRSCLGVAALHGLLYSAGG 443
Score = 29.6 bits (65), Expect = 7.2
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 7/78 (8%)
Query: 301 GDLYVVGG----SIPRRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTL 356
G LYV GG S + + + WE AP+ R H LV++ G +Y++GG
Sbjct: 530 GALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDG--WLYAVGGNDG 587
Query: 357 QDTLSNAVIYYRVGDNVW 374
+L N++ Y N W
Sbjct: 588 SSSL-NSIEKYNPRTNKW 604
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 102 bits (253), Expect = 1e-21
Identities = 118/507 (23%), Positives = 199/507 (39%), Gaps = 82/507 (16%)
Query: 37 FKDRSHSGRVAQGIMKLCLEEELFADVTISVEGRE--FQLHRLVLSAQSCFFRSMFTSNL 94
F +HS V QG +L LE L DVT+ + F +HR+++++ S +F++MFT +
Sbjct: 69 FTSNTHSSVVLQGFDQLRLEG-LLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGM 127
Query: 95 KEAHNRVIVLQDVSESVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFL 154
KE I L VS+ + ++D+IY + L + LQ+ E + Q+ + + C FL
Sbjct: 128 KEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 187
Query: 155 ARTVQVGNCLQVMWLADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISDG 214
V + NC++V +A+ ++ E+ + L +T EFL LP L ++S
Sbjct: 188 ISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSN 247
Query: 215 VPCSQNPTEAIEA---WINFNKEEREAFAESLRTSLK---EIGENVHIYLIGKESSRTHS 268
E +A W+ +E R FA L +++ + + Y+ + RT +
Sbjct: 248 SLKHCTELELFKATCRWLRL-EEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDN 306
Query: 269 LAVSLHC-AEDDSISVSGQNSLCHQITAACKHGGDLYVVGG------SIPRRMWKCNNAT 321
V+L A + + Q + TA L +GG + + + +
Sbjct: 307 TCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKA 366
Query: 322 VDWEWCAPLPRDRLQH------TLVSVPGKDAIYSLGGKTLQDTLSN------------- 362
+W+ AP+ R QH + V G + Y GKT DT+
Sbjct: 367 HEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVAS 426
Query: 363 ------------------------------AVIYYRVGDNVWTETTQLEVAVSGAAGANL 392
V Y N WT ++ G AG
Sbjct: 427 LNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVY 486
Query: 393 NGIIYLLGGEENDLDFFTKPSRLIQCFDTETDKCHVKPYVLPFAGRMHAAVHKDLVFIVA 452
G++Y+ GG +D F K + CFD +TDK K + G + ++++
Sbjct: 487 GGVMYISGGITHDT--FQKE---LMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIG 541
Query: 453 EG---------DSLVC--YNPLLDSFT 468
D L C Y+P+LD +T
Sbjct: 542 GNHFRGTSDYDDVLSCEYYSPILDQWT 568
>gi|227497736 T-cell activation kelch repeat protein [Homo sapiens]
Length = 601
Score = 101 bits (252), Expect = 1e-21
Identities = 105/441 (23%), Positives = 179/441 (40%), Gaps = 46/441 (10%)
Query: 51 MKLCLEEELFADVTISVE-GREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSE 109
+K +E D+ + V+ G+ F HR VL+A S +FRSMFTS L E+ + + + V
Sbjct: 39 LKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEA 98
Query: 110 SVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWL 169
L+++Y Y V L +Q ++ + ++Q+ S+ ++C++++ + N + V
Sbjct: 99 ESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIF 158
Query: 170 ADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISD---GVPCSQNPTEAIE 226
AD + EL +K + + +EFL L L I+ V ++ E+I
Sbjct: 159 ADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESII 218
Query: 227 AWINFNKEEREA-----FAESLRTSLKEIGENVHIYLIGKESSRTHSLAVSLHCAEDDSI 281
W + ERE FA+ +R L E+ I I + ++ A++ C E
Sbjct: 219 RWFEHEQNEREVHLPEIFAKCIRFPLM---EDTFIEKIPPQFAQ----AIAKSCVEKGPS 271
Query: 282 SVSG--------QNSLCHQITAACKHGGDLYVVG--GSIPRRMWKCNNATVDWEWCAPLP 331
+ +G + + AA KH G V + R++K C P P
Sbjct: 272 NTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKL---------CKP-P 321
Query: 332 RDRLQHTLVSVPGKDAIYSLGG-------KTLQDTLSNAVIYYRVGDNVWTETTQLEVAV 384
D + ++ P D IY GG ++ N Y N W L A
Sbjct: 322 NDLREVGILVSPDND-IYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRAR 380
Query: 385 SGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQCFDTETDKCHVKPYVLPFAGRMHAAVH 444
G G +Y +GG + D + ++C+D+ + C +P A H AV
Sbjct: 381 IGCKLVYCCGKMYAIGGRVYEGD-GRNSLKSVECYDSR-ENCWTTVCAMPVAMEFHNAVE 438
Query: 445 KDLVFIVAEGDSLVCYNPLLD 465
V +G+ + Y P D
Sbjct: 439 YKEKIYVLQGEFFLFYEPQKD 459
>gi|38327518 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 101 bits (251), Expect = 2e-21
Identities = 95/450 (21%), Positives = 181/450 (40%), Gaps = 82/450 (18%)
Query: 44 GRVAQGIMKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIV 103
G+ +++ E+ +F D I ++ HR VL+A S FFR+MF N+KE + +
Sbjct: 35 GQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVT 94
Query: 104 LQDVSESVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNC 163
+ ++S + +DY Y G K+ + ++ +++S Q++ L + CS FL +++ + NC
Sbjct: 95 ITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSINLVNC 154
Query: 164 LQVMWLADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISD---GVPCSQN 220
LQ++ ++D + L+ A H + H + L + +FL + +L + VP +
Sbjct: 155 LQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEEEM 214
Query: 221 PTEAIEAWINFNKEEREAFAESL--RTSLKEIG-ENVHIYLIGKES-------------- 263
+ + +W N E R+ + L + L ++ E + L +ES
Sbjct: 215 VLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDIIMDA 274
Query: 264 ---------------SRTHSLAVSLHCAEDDSISVSGQNSLCHQI--------------- 293
T + +H E++ Q + C+ I
Sbjct: 275 IKCVQGSGGLFPDARPSTTEKYIFIHKTEENG---ENQYTFCYNIKSDSWKILPQSHLID 331
Query: 294 ---TAACKHGGDLYVVGG-------SIPRRMWKCNNATVDWEWC-APLPRD--------- 333
++ +G +++ GG ++ + + + D WC P+ D
Sbjct: 332 LPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPVKNDFFLVSTMKT 391
Query: 334 -RLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVI---YYRVGDNVWTETTQLEVAVSGAAG 389
R HT SV D ++ +GGKT +++ Y W + L +
Sbjct: 392 PRTMHT--SVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYYPEA 449
Query: 390 ANLNGIIYLLGGEENDLDFFTKPSRLIQCF 419
+ +IY+LG E D F PS + CF
Sbjct: 450 STCQNVIYVLGSEVEITDAF-NPS--LDCF 476
>gi|38327516 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 101 bits (251), Expect = 2e-21
Identities = 95/450 (21%), Positives = 181/450 (40%), Gaps = 82/450 (18%)
Query: 44 GRVAQGIMKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIV 103
G+ +++ E+ +F D I ++ HR VL+A S FFR+MF N+KE + +
Sbjct: 35 GQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVT 94
Query: 104 LQDVSESVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNC 163
+ ++S + +DY Y G K+ + ++ +++S Q++ L + CS FL +++ + NC
Sbjct: 95 ITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSINLVNC 154
Query: 164 LQVMWLADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISD---GVPCSQN 220
LQ++ ++D + L+ A H + H + L + +FL + +L + VP +
Sbjct: 155 LQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEEEM 214
Query: 221 PTEAIEAWINFNKEEREAFAESL--RTSLKEIG-ENVHIYLIGKES-------------- 263
+ + +W N E R+ + L + L ++ E + L +ES
Sbjct: 215 VLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDIIMDA 274
Query: 264 ---------------SRTHSLAVSLHCAEDDSISVSGQNSLCHQI--------------- 293
T + +H E++ Q + C+ I
Sbjct: 275 IKCVQGSGGLFPDARPSTTEKYIFIHKTEENG---ENQYTFCYNIKSDSWKILPQSHLID 331
Query: 294 ---TAACKHGGDLYVVGG-------SIPRRMWKCNNATVDWEWC-APLPRD--------- 333
++ +G +++ GG ++ + + + D WC P+ D
Sbjct: 332 LPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPVKNDFFLVSTMKT 391
Query: 334 -RLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVI---YYRVGDNVWTETTQLEVAVSGAAG 389
R HT SV D ++ +GGKT +++ Y W + L +
Sbjct: 392 PRTMHT--SVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYYPEA 449
Query: 390 ANLNGIIYLLGGEENDLDFFTKPSRLIQCF 419
+ +IY+LG E D F PS + CF
Sbjct: 450 STCQNVIYVLGSEVEITDAF-NPS--LDCF 476
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,497,046
Number of Sequences: 37866
Number of extensions: 916103
Number of successful extensions: 2368
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 149
Number of HSP's successfully gapped in prelim test: 49
Number of HSP's that attempted gapping in prelim test: 1945
Number of HSP's gapped (non-prelim): 345
length of query: 534
length of database: 18,247,518
effective HSP length: 107
effective length of query: 427
effective length of database: 14,195,856
effective search space: 6061630512
effective search space used: 6061630512
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.