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Search of human proteins with 20149598
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20149598 solute carrier family 25 (mitochondrial carrier;
dicarboxylate transporter), member 10 [Homo sapiens]
(287 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20149598 solute carrier family 25 (mitochondrial carrier; dic... 573 e-164
gi|21361114 solute carrier family 25 (mitochondrial carrier; oxo... 194 6e-50
gi|13259541 uncoupling protein 2 [Homo sapiens] 167 8e-42
gi|11225256 uncoupling protein 1 [Homo sapiens] 162 3e-40
gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens] 160 1e-39
gi|58197562 solute carrier family 25, member 30 [Homo sapiens] 146 2e-35
gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens] 145 3e-35
gi|108860679 solute carrier family 25, member 27 [Homo sapiens] 137 1e-32
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho... 134 9e-32
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H... 134 9e-32
gi|46409330 solute carrier family 25, member 34 [Homo sapiens] 117 1e-26
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 88 8e-18
gi|157388925 solute carrier family 25, member 38 [Homo sapiens] 82 7e-16
gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens] 80 3e-15
gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens] 76 3e-14
gi|116235462 solute carrier family 25, member 45 isoform a [Homo... 75 5e-14
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 75 9e-14
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ... 73 3e-13
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s... 73 3e-13
gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 72 4e-13
gi|239755174 PREDICTED: similar to solute carrier family 25, mem... 72 4e-13
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ... 72 4e-13
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ... 72 4e-13
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ... 72 4e-13
gi|56699403 solute carrier family 25, member 25 isoform b [Homo ... 72 4e-13
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 72 7e-13
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 72 7e-13
gi|48476342 solute carrier family 25, member 23 [Homo sapiens] 72 7e-13
gi|41462412 solute carrier family 25, member 35 [Homo sapiens] 70 2e-12
gi|60460887 solute carrier family 25, member 42 [Homo sapiens] 69 5e-12
>gi|20149598 solute carrier family 25 (mitochondrial carrier;
dicarboxylate transporter), member 10 [Homo sapiens]
Length = 287
Score = 573 bits (1476), Expect = e-164
Identities = 287/287 (100%), Positives = 287/287 (100%)
Query: 1 MAAEARVSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALRVVRTDGILAL 60
MAAEARVSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALRVVRTDGILAL
Sbjct: 1 MAAEARVSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALRVVRTDGILAL 60
Query: 61 YSGLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPA 120
YSGLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPA
Sbjct: 61 YSGLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPA 120
Query: 121 DLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLS 180
DLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLS
Sbjct: 121 DLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLS 180
Query: 181 CYDQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHC 240
CYDQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHC
Sbjct: 181 CYDQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHC 240
Query: 241 AVETAKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGIKVPS 287
AVETAKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGIKVPS
Sbjct: 241 AVETAKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGIKVPS 287
>gi|21361114 solute carrier family 25 (mitochondrial carrier;
oxoglutarate carrier), member 11 [Homo sapiens]
Length = 314
Score = 194 bits (494), Expect = 6e-50
Identities = 110/284 (38%), Positives = 156/284 (54%), Gaps = 11/284 (3%)
Query: 9 RWYFGGLASCGAACCTHPLDLLKVHLQTQQE-VKLRMTGMALR----VVRTDGILALYSG 63
++ FGGLA GA PLDL+K +Q E K R + +++ +G+ +Y+G
Sbjct: 24 KFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTG 83
Query: 64 LSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLV 123
LSA L RQ TY+ TR IY + +R+ P F K ++G +G G FVGTPA++
Sbjct: 84 LSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVA 143
Query: 124 NVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYD 183
+RM D +LP QRR Y + + L R+ REEG+ L+ G +R +V QL+ Y
Sbjct: 144 LIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYS 203
Query: 184 QAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMN-----SKGEYQGVF 238
Q+KQ +L +GY SDNI HF AS I+G T P+D+ KTR+ N K EY+
Sbjct: 204 QSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEYKNGL 263
Query: 239 HCAVETAKL-GPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNF 281
+ + G + +KG P RL PHTVLTF+FLEQ+ K +
Sbjct: 264 DVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAY 307
Score = 50.4 bits (119), Expect = 2e-06
Identities = 41/175 (23%), Positives = 69/175 (39%), Gaps = 10/175 (5%)
Query: 98 PFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGL 157
P K L G ++G+ P DLV RMQ + + R Y + L + + EGL
Sbjct: 20 PKSVKFLFGGLAGMGATVFVQPLDLVKNRMQ--LSGEGAKTREYKTSFHALTSILKAEGL 77
Query: 158 RRLFSGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLC 217
R +++G + R A T +L Y + + V AG F+
Sbjct: 78 RGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVG 137
Query: 218 QPLDVLKTRL-------MNSKGEYQGVFHCAVE-TAKLGPLAFYKGLVPAGIRLI 264
P +V R+ + + Y+ VF+ + T + G L ++G +P R +
Sbjct: 138 TPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAV 192
>gi|13259541 uncoupling protein 2 [Homo sapiens]
Length = 309
Score = 167 bits (424), Expect = 8e-42
Identities = 106/279 (37%), Positives = 153/279 (54%), Gaps = 16/279 (5%)
Query: 14 GLASCGAACCTHPLDLLKVHLQTQQEVK--LRMT---------GMALRVVRTDGILALYS 62
G A+C A T PLD KV LQ Q E + +R T G L +VRT+G +LY+
Sbjct: 21 GTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYN 80
Query: 63 GLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADL 122
GL A L RQM+++ R +Y++V+ KGS+ ++L GS +G V P D+
Sbjct: 81 GLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHA-SIGSRLLAGSTTGALAVAVAQPTDV 139
Query: 123 VNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCY 182
V VR Q + G+R Y ++ +AREEG R L+ G + +R A+V +L Y
Sbjct: 140 VKVRFQAQARAGGGRR--YQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTY 197
Query: 183 DQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSK-GEYQGVFHCA 241
D K +L ++D++ HF ++F AG C T + P+DV+KTR MNS G+Y HCA
Sbjct: 198 DLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCA 257
Query: 242 VE-TAKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRK 279
+ K GP AFYKG +P+ +RL V+ FV EQL++
Sbjct: 258 LTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296
>gi|11225256 uncoupling protein 1 [Homo sapiens]
Length = 307
Score = 162 bits (410), Expect = 3e-40
Identities = 99/278 (35%), Positives = 150/278 (53%), Gaps = 10/278 (3%)
Query: 11 YFGGLASCGAACCTHPLDLLKVHLQTQQEVKLR-------MTGMALRVVRTDGILALYSG 63
+ G+A+C A T PLD KV LQ Q E + G VV+T+G + LYSG
Sbjct: 18 FSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYSG 77
Query: 64 LSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLV 123
L A L RQ++ + R +Y+TV++ + G + K+L G +G F+G P ++V
Sbjct: 78 LPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVV 137
Query: 124 NVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYD 183
VR+Q L G + Y + +A EGL L+ G T R ++ +L YD
Sbjct: 138 KVRLQAQSHL-HGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYD 196
Query: 184 QAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNS-KGEYQGVFHCAV 242
K+ + L+D++ H V++ IAG CAT + P+DV+KTR +NS G+Y+ V +CA+
Sbjct: 197 LMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAM 256
Query: 243 ET-AKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRK 279
+ GP AF+KGLVP+ +RL V+ FV EQL++
Sbjct: 257 KVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKR 294
>gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]
Length = 312
Score = 160 bits (405), Expect = 1e-39
Identities = 102/279 (36%), Positives = 145/279 (51%), Gaps = 13/279 (4%)
Query: 14 GLASCGAACCTHPLDLLKVHLQTQQEVKLRMT----------GMALRVVRTDGILALYSG 63
G A+C A T PLD KV LQ Q E + T G L +VRT+G + Y+G
Sbjct: 21 GTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNG 80
Query: 64 LSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLV 123
L A L RQM+++ R +Y++V+ ++L G +G P D+V
Sbjct: 81 LVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVV 140
Query: 124 NVRMQNDVKL-PQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCY 182
VR Q + L P R Y+ +D +AREEG+R L+ G R A+V ++ Y
Sbjct: 141 KVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTY 200
Query: 183 DQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNS-KGEYQGVFHCA 241
D K+ +L L+DN HFV++F AG CAT + P+DV+KTR MNS G+Y C
Sbjct: 201 DILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQYFSPLDCM 260
Query: 242 VE-TAKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRK 279
++ A+ GP AFYKG P+ +RL V+ FV EQL++
Sbjct: 261 IKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKR 299
Score = 47.4 bits (111), Expect = 1e-05
Identities = 46/196 (23%), Positives = 80/196 (40%), Gaps = 28/196 (14%)
Query: 20 AACCTHPLDLLKVHLQ-------TQQEVKLRMTGMALRVV-RTDGILALYSGLSASLCRQ 71
A C P D++KV Q ++ + K T A R + R +G+ L+ G ++ R
Sbjct: 130 AVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRN 189
Query: 72 MTYSLTRFAIYETVRDRVAKGSQGPLPFH---EKVLLGSVSGLAGGF----VGTPADLVN 124
+ Y+ +++++ L +H + VS GF V +P D+V
Sbjct: 190 AIVNCAEVVTYDILKEKL-------LDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVK 242
Query: 125 VRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYDQ 184
R N P GQ Y LD + ++ +EG + G T + R V Y+Q
Sbjct: 243 TRYMNS---PPGQ---YFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQ 296
Query: 185 AKQLVLSTGYLSDNIF 200
K+ ++ L ++ F
Sbjct: 297 LKRALMKVQMLRESPF 312
>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
Length = 291
Score = 146 bits (369), Expect = 2e-35
Identities = 90/286 (31%), Positives = 149/286 (52%), Gaps = 26/286 (9%)
Query: 12 FGGLASCGAACCTHPLDLLKVHLQTQQEV------KLRMTGMA---LRVVRTDGILALYS 62
+GGLAS A C T P+DL K LQ Q + ++R GM +R+ R +G+ ALYS
Sbjct: 11 YGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLKALYS 70
Query: 63 GLSASLCRQMTYSLTRFAIYETVRDR-VAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPAD 121
G++ ++ RQ +Y + Y++++ + + LP + V+ G +SG+ + P D
Sbjct: 71 GIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDETLPIN--VICGILSGVISSTIANPTD 128
Query: 122 LVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSC 181
++ +RMQ QG + + ++EG R L+ G ++ + R A+V +L
Sbjct: 129 VLKIRMQAQSNTIQGGM------IGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVGVELPV 182
Query: 182 YDQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSK-------GEY 234
YD K+ ++ +G + D ++THF++SF G P+DV++TR+MN + Y
Sbjct: 183 YDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQRVLRDGRCSGY 242
Query: 235 QGVFHCAVETAK-LGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRK 279
G C ++T K G A YKG P +RL P ++ FV EQL+K
Sbjct: 243 TGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKK 288
>gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]
Length = 275
Score = 145 bits (367), Expect = 3e-35
Identities = 93/255 (36%), Positives = 131/255 (51%), Gaps = 13/255 (5%)
Query: 14 GLASCGAACCTHPLDLLKVHLQTQQEVKLRMT----------GMALRVVRTDGILALYSG 63
G A+C A T PLD KV LQ Q E + T G L +VRT+G + Y+G
Sbjct: 21 GTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNG 80
Query: 64 LSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLV 123
L A L RQM+++ R +Y++V+ ++L G +G P D+V
Sbjct: 81 LVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVV 140
Query: 124 NVRMQNDVKL-PQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCY 182
VR Q + L P R Y+ +D +AREEG+R L+ G R A+V ++ Y
Sbjct: 141 KVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTY 200
Query: 183 DQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNS-KGEYQGVFHCA 241
D K+ +L L+DN HFV++F AG CAT + P+DV+KTR MNS G+Y C
Sbjct: 201 DILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQYFSPLDCM 260
Query: 242 VE-TAKLGPLAFYKG 255
++ A+ GP AFYKG
Sbjct: 261 IKMVAQEGPTAFYKG 275
>gi|108860679 solute carrier family 25, member 27 [Homo sapiens]
Length = 323
Score = 137 bits (345), Expect = 1e-32
Identities = 91/302 (30%), Positives = 151/302 (50%), Gaps = 24/302 (7%)
Query: 6 RVSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTG--------------MALRV 51
R S++ G A+ A T PLDL K LQ Q E L G AL +
Sbjct: 19 RASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGI 78
Query: 52 VRTDGILALYSGLSASLCRQMTYSLTRFAIYETVRDRV-AKGSQGPLPFHEKVLLGSVSG 110
+ +G L L+ G++ ++ R + YS R YE +R+ V K P + V+ G ++G
Sbjct: 79 IEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAG 138
Query: 111 LAGGFVGTPADLVNVRMQNDVKLP-QGQRRNYAHALDGLYRVAREEGLRRLFSGATMASS 169
+ G F+ P DLV V+MQ + K +G+ + ++ E G+R L++G
Sbjct: 139 VIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQ 198
Query: 170 RGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMN 229
R ALV +G L+ YD K ++ L DNI TH ++S +G A+ L P DV+K+R+MN
Sbjct: 199 RAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMN 258
Query: 230 SKGEYQG-------VFHCAVETAK-LGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNF 281
+ QG C ++ + G ++ YKG +P+ +R+ P +++ ++ E++R+
Sbjct: 259 QPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIREMS 318
Query: 282 GI 283
G+
Sbjct: 319 GV 320
>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
sapiens]
Length = 325
Score = 134 bits (337), Expect = 9e-32
Identities = 90/284 (31%), Positives = 144/284 (50%), Gaps = 23/284 (8%)
Query: 12 FGGLASCGAACCTHPLDLLKVHLQTQ--------QEVKLRMTGMAL-RVVRTDGILALYS 62
+GGLAS A T P+DL K LQ Q +E+K R AL R+ + +G+LALYS
Sbjct: 46 YGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYS 105
Query: 63 GLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADL 122
G++ +L RQ +Y + IY++++ + + ++ G VSG+ + P D+
Sbjct: 106 GIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLIN-MICGVVSGVISSTIANPTDV 164
Query: 123 VNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCY 182
+ +RMQ L QG + + ++EG R L+ G + R A+V +L Y
Sbjct: 165 LKIRMQAQGSLFQGSM------IGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVY 218
Query: 183 DQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKG------EYQG 236
D K+ ++ +G + D I THFV+SF G P+DV++TR+MN + Y+G
Sbjct: 219 DITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKG 278
Query: 237 VFHCAVETAK-LGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRK 279
++ K G A YKG P +RL P ++ F+ EQL++
Sbjct: 279 TVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 322
Score = 37.0 bits (84), Expect = 0.020
Identities = 29/116 (25%), Positives = 52/116 (44%), Gaps = 19/116 (16%)
Query: 185 AKQLVLSTGYLSDNIFTHFVAS-----FIAGGCATFLCQ----PLDVLKTRLMNS----- 230
A V+ +G+ +H ++ F+ GG A+ + + P+D+ KTRL
Sbjct: 17 ATAAVIVSGHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSID 76
Query: 231 ----KGEYQGVFHCAVETAKL-GPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNF 281
+ +Y+G+FH K G LA Y G+ PA +R + + + L++ F
Sbjct: 77 ARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLF 132
>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
sapiens]
Length = 322
Score = 134 bits (337), Expect = 9e-32
Identities = 90/284 (31%), Positives = 144/284 (50%), Gaps = 23/284 (8%)
Query: 12 FGGLASCGAACCTHPLDLLKVHLQTQ--------QEVKLRMTGMAL-RVVRTDGILALYS 62
+GGLAS A T P+DL K LQ Q +E+K R AL R+ + +G+LALYS
Sbjct: 43 YGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYS 102
Query: 63 GLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADL 122
G++ +L RQ +Y + IY++++ + + ++ G VSG+ + P D+
Sbjct: 103 GIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLIN-MICGVVSGVISSTIANPTDV 161
Query: 123 VNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCY 182
+ +RMQ L QG + + ++EG R L+ G + R A+V +L Y
Sbjct: 162 LKIRMQAQGSLFQGSM------IGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVY 215
Query: 183 DQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKG------EYQG 236
D K+ ++ +G + D I THFV+SF G P+DV++TR+MN + Y+G
Sbjct: 216 DITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKG 275
Query: 237 VFHCAVETAK-LGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRK 279
++ K G A YKG P +RL P ++ F+ EQL++
Sbjct: 276 TVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 319
Score = 36.2 bits (82), Expect = 0.034
Identities = 25/89 (28%), Positives = 42/89 (47%), Gaps = 14/89 (15%)
Query: 207 FIAGGCATFLCQ----PLDVLKTRLM---------NSKGEYQGVFHCAVETAK-LGPLAF 252
F+ GG A+ + + P+D+ KTRL + +Y+G+FH K G LA
Sbjct: 41 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLAL 100
Query: 253 YKGLVPAGIRLIPHTVLTFVFLEQLRKNF 281
Y G+ PA +R + + + L++ F
Sbjct: 101 YSGIAPALLRQASYGTIKIGIYQSLKRLF 129
>gi|46409330 solute carrier family 25, member 34 [Homo sapiens]
Length = 304
Score = 117 bits (293), Expect = 1e-26
Identities = 92/290 (31%), Positives = 135/290 (46%), Gaps = 25/290 (8%)
Query: 13 GGLASCGAACCTHPLDLLKVHLQTQQEVKLRMT---------GMALRVVRTDGILALYSG 63
G A C A T+PL+++K LQ Q E++ R T V R DG+ L G
Sbjct: 13 GASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWGLQKG 72
Query: 64 LSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLV 123
L+A L Q + RF Y G V+ G+V+G G FVG+PA L+
Sbjct: 73 LAAGLLYQGLMNGVRFYCYSLACQAGLTQQPGGT-----VVAGAVAGALGAFVGSPAYLI 127
Query: 124 NVRMQNDV--KLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSC 181
++Q + G + N+ L L + R++GL L+ G A R + + QL+
Sbjct: 128 KTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAAQLAT 187
Query: 182 YDQAKQLVLSTGYL-SDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNS------KGE- 233
+ AK V +L D+ I+ + P DV+ TRL N +G+
Sbjct: 188 FASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAGRGQL 247
Query: 234 YQGVFHCAVETAKL-GPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFG 282
Y G+ C V+ + GPLA YKGL PA +RL PHT+L+ +F ++LRK G
Sbjct: 248 YGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELRKLAG 297
>gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
Length = 311
Score = 88.2 bits (217), Expect = 8e-18
Identities = 80/281 (28%), Positives = 128/281 (45%), Gaps = 24/281 (8%)
Query: 13 GGLASCGAACCTHPLDLLKVHLQTQQEV---KLRMTGMALR-VVRTDGILALYSGLSASL 68
GGLA C T P + +K LQ + + R G +R VR+ G+L LY GLS+ L
Sbjct: 32 GGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLL 91
Query: 69 CRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGT-PADLVNVRM 127
+ + RF ++E + + + + +QG L +L G +G+A V P + + V+
Sbjct: 92 YGSIPKAAVRFGMFEFLSNHM-RDAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETIKVKF 150
Query: 128 QNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYDQAKQ 187
+D P + R + H G+ + RE+GL+ + G T ++ G
Sbjct: 151 IHDQTSPNPKYRGFFH---GVREIVREQGLKGTYQGLT-----ATVLKQGSNQAIRFFVM 202
Query: 188 LVLSTGYLSDN-------IFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKG-EYQGVFH 239
L Y DN + T V IAG + F PLDV+KTR+ + +Y+ +
Sbjct: 203 TSLRNWYRGDNPNKPMNPLITG-VFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTWD 261
Query: 240 CAVETAKL-GPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRK 279
C ++ K G AFYKG VP R+ + FV +++ K
Sbjct: 262 CGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVK 302
Score = 55.5 bits (132), Expect = 5e-08
Identities = 46/182 (25%), Positives = 82/182 (45%), Gaps = 15/182 (8%)
Query: 14 GLASCGAACCTHPLDLLKV---HLQTQQEVKLRMTGMALR-VVRTDGILALYSGLSASLC 69
G+A C P++ +KV H QT K R +R +VR G+ Y GL+A++
Sbjct: 132 GVAEAVVVVC--PMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVL 189
Query: 70 RQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKV--LLGSVSGLAGGFVGTPADLVNVRM 127
+Q + RF + ++R+ +G P + + + G+++G A F TP D++ RM
Sbjct: 190 KQGSNQAIRFFVMTSLRNWY-RGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRM 248
Query: 128 QNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYDQAKQ 187
Q + Y + D ++ ++EGL+ + G R L YD+ +
Sbjct: 249 QGL------EAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVK 302
Query: 188 LV 189
L+
Sbjct: 303 LL 304
Score = 35.4 bits (80), Expect = 0.058
Identities = 22/75 (29%), Positives = 35/75 (46%), Gaps = 1/75 (1%)
Query: 12 FGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMT-GMALRVVRTDGILALYSGLSASLCR 70
FG +A + PLD++K +Q + K R T L++++ +G+ A Y G L R
Sbjct: 226 FGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGR 285
Query: 71 QMTYSLTRFAIYETV 85
F IY+ V
Sbjct: 286 VCLDVAIVFVIYDEV 300
>gi|157388925 solute carrier family 25, member 38 [Homo sapiens]
Length = 304
Score = 81.6 bits (200), Expect = 7e-16
Identities = 75/278 (26%), Positives = 118/278 (42%), Gaps = 19/278 (6%)
Query: 17 SCGAACCT---HPLDLLKVHLQTQQEV-----KLRMTGMALRVVRTDGILALYSGLSASL 68
S C T PLDLLK LQT Q ++ M + L+VVRT+ +L L+ G+S S+
Sbjct: 35 SISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLWKGMSPSI 94
Query: 69 CRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQ 128
R + F +++ +G P E V+LG S G +P ++ R +
Sbjct: 95 VRCVPGVGIYFGTLYSLKQYFLRGH--PPTALESVMLGVGSRSVAGVCMSPITVIKTRYE 152
Query: 129 NDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYDQAKQL 188
+ + Y L + EG R LFSG T R A + L Y+Q K +
Sbjct: 153 SG-------KYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKNI 205
Query: 189 VLSTGYLSDNI-FTHFVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETAK- 246
V + I T+F AG A+ + QP DV+KT + ++Q + K
Sbjct: 206 VPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQLYPLKFQWIGQAVTLIFKD 265
Query: 247 LGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGIK 284
G F++G +P +R + + E++ G+K
Sbjct: 266 YGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAKMGLK 303
Score = 43.9 bits (102), Expect = 2e-04
Identities = 30/87 (34%), Positives = 43/87 (49%), Gaps = 10/87 (11%)
Query: 203 FVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQG--------VFHCAVETAKLGPLAFYK 254
F+ I+G C+T L QPLD+LKTRL + G V V T L L +K
Sbjct: 31 FLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESL--LGLWK 88
Query: 255 GLVPAGIRLIPHTVLTFVFLEQLRKNF 281
G+ P+ +R +P + F L L++ F
Sbjct: 89 GMSPSIVRCVPGVGIYFGTLYSLKQYF 115
Score = 38.1 bits (87), Expect = 0.009
Identities = 47/188 (25%), Positives = 77/188 (40%), Gaps = 17/188 (9%)
Query: 98 PFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGL 157
P + L GS+SG + P DL+ R+Q G RR L L +V R E L
Sbjct: 26 PVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRR--VGMLAVLLKVVRTESL 83
Query: 158 RRLFSGATMASSR---GALVTVGQLSCYDQAKQLVL--STGYLSDNIFTHFVASFIAGGC 212
L+ G + + R G + G L KQ L +++ + +AG C
Sbjct: 84 LGLWKGMSPSIVRCVPGVGIYFGTLY---SLKQYFLRGHPPTALESVMLGVGSRSVAGVC 140
Query: 213 ATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETA--KLGPLAFYKGLVPAGIRLIPHTVLT 270
+ P+ V+KTR + K Y+ ++ A+ + G + GL +R P + +
Sbjct: 141 MS----PITVIKTRYESGKYGYESIY-AALRSIYHSEGHRGLFSGLTATLLRDAPFSGIY 195
Query: 271 FVFLEQLR 278
+F Q +
Sbjct: 196 LMFYNQTK 203
>gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens]
Length = 308
Score = 79.7 bits (195), Expect = 3e-15
Identities = 79/291 (27%), Positives = 119/291 (40%), Gaps = 38/291 (13%)
Query: 18 CGAACCTHPLDLLKVHLQTQQEVKLRMTGMALRVVRT---DGILALYSGLSASLCRQMTY 74
CG A +PLD +KV +QT+ + TG+ V T + + Y GLS +C
Sbjct: 12 CGVAV-GYPLDTVKVRIQTEP----KYTGIWHCVRDTYHRERVWGFYRGLSLPVCTVSLV 66
Query: 75 SLTRFAIYETVRDRVAK---GSQGPLPFHEKVLL-GSVSGLAGGFVGTPADLVNVRMQND 130
S F Y + + G+ P + L G SGL F+ +P ++ VR+Q
Sbjct: 67 SSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLTSPTEVAKVRLQTQ 126
Query: 131 VKLPQGQRR----------------------NYAHALDGLYRVAREEGLRRLFSGATMAS 168
+ + QRR Y L L VAREEGL L+ G++
Sbjct: 127 TQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEGLCGLYKGSSALV 186
Query: 169 SRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLM 228
R Y + + G+ ++ VA AG A + P+DV+K+RL
Sbjct: 187 LRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGVLVAGGCAGVLAWAVATPMDVIKSRLQ 246
Query: 229 ---NSKGEYQGVFHCAVETAK-LGPLAFYKGLVPAGIRLIPHTVLTFVFLE 275
+ Y+G+ HC V + + GP +KGLV R P ++ FV E
Sbjct: 247 ADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCCRAFPVNMVVFVAYE 297
Score = 50.4 bits (119), Expect = 2e-06
Identities = 40/138 (28%), Positives = 59/138 (42%), Gaps = 4/138 (2%)
Query: 51 VVRTDGILALYSGLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSG 110
V R +G+ LY G SA + R T F Y + + ++ ++ G +G
Sbjct: 169 VAREEGLCGLYKGSSALVLRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGVLVAGGCAG 228
Query: 111 LAGGFVGTPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSR 170
+ V TP D++ R+Q D QGQRR Y L + REEG R LF G + R
Sbjct: 229 VLAWAVATPMDVIKSRLQAD---GQGQRR-YRGLLHCMVTSVREEGPRVLFKGLVLNCCR 284
Query: 171 GALVTVGQLSCYDQAKQL 188
V + Y+ +L
Sbjct: 285 AFPVNMVVFVAYEAVLRL 302
Score = 38.9 bits (89), Expect = 0.005
Identities = 26/83 (31%), Positives = 40/83 (48%), Gaps = 4/83 (4%)
Query: 13 GGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMA---LRVVRTDGILALYSGLSASLC 69
GG A A P+D++K LQ + + R G+ + VR +G L+ GL + C
Sbjct: 224 GGCAGVLAWAVATPMDVIKSRLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCC 283
Query: 70 RQMTYSLTRFAIYETVRDRVAKG 92
R ++ F YE V R+A+G
Sbjct: 284 RAFPVNMVVFVAYEAVL-RLARG 305
Score = 37.0 bits (84), Expect = 0.020
Identities = 20/55 (36%), Positives = 31/55 (56%), Gaps = 2/55 (3%)
Query: 203 FVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETAKLGPL-AFYKGL 256
FVA I G C + PLD +K R+ ++ +Y G++HC +T + FY+GL
Sbjct: 3 FVAGAIGGVCGVAVGYPLDTVKVRI-QTEPKYTGIWHCVRDTYHRERVWGFYRGL 56
Score = 30.4 bits (67), Expect = 1.9
Identities = 33/127 (25%), Positives = 48/127 (37%), Gaps = 14/127 (11%)
Query: 106 GSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGAT 165
G++ G+ G VG P D V VR+Q + K H + Y R G R G +
Sbjct: 6 GAIGGVCGVAVGYPLDTVKVRIQTEPKY-----TGIWHCVRDTYHRERVWGFYR---GLS 57
Query: 166 MASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVASFIAGGCAT-----FLCQPL 220
+ +LV+ Y + Y + + A GCA+ FL P
Sbjct: 58 LPVCTVSLVSSVSFGTYRHCLAHICRLRYGNPDA-KPTKADITLSGCASGLVRVFLTSPT 116
Query: 221 DVLKTRL 227
+V K RL
Sbjct: 117 EVAKVRL 123
>gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens]
Length = 323
Score = 76.3 bits (186), Expect = 3e-14
Identities = 68/284 (23%), Positives = 114/284 (40%), Gaps = 32/284 (11%)
Query: 13 GGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMA---LRVVRTDGILALYSGLSASLC 69
GG+A C P+DL K LQ QQ + T M+ ++ VR++G +Y G + +L
Sbjct: 15 GGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAVNLT 74
Query: 70 RQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQN 129
+ A + R +++K Q L +++L G +G V TP +++ +++Q+
Sbjct: 75 LVTPEKAIKLAANDFFRHQLSKDGQ-KLTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQD 133
Query: 130 DVKLP--------QGQRRNYAHALDGLYRVA--------------REEGLRRLFSGATMA 167
++ QGQ A + A R G+ L+ G
Sbjct: 134 AGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKGLGAT 193
Query: 168 SSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRL 227
R +V + QL + F+A +AG A P DV+KTRL
Sbjct: 194 LLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRL 253
Query: 228 MN-----SKGEYQGVFHCAVETAK-LGPLAFYKGLVPAGIRLIP 265
+ ++ Y G+ CA + + GP AF KG + + P
Sbjct: 254 QSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAP 297
Score = 41.6 bits (96), Expect = 8e-04
Identities = 32/129 (24%), Positives = 56/129 (43%), Gaps = 5/129 (3%)
Query: 102 KVLLGSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLF 161
K++ G ++GL G P DL R+QN Q +R Y D L + R EG ++
Sbjct: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQ----QNGQRVYTSMSDCLIKTVRSEGYFGMY 66
Query: 162 SGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLD 221
GA + + +L+ D + + G + +A AG C + P++
Sbjct: 67 RGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQ-KLTLLKEMLAGCGAGTCQVIVTTPME 125
Query: 222 VLKTRLMNS 230
+LK +L ++
Sbjct: 126 MLKIQLQDA 134
>gi|116235462 solute carrier family 25, member 45 isoform a [Homo
sapiens]
Length = 288
Score = 75.5 bits (184), Expect = 5e-14
Identities = 74/295 (25%), Positives = 117/295 (39%), Gaps = 20/295 (6%)
Query: 1 MAAEARVSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALRVVRTDGILAL 60
M E V+ W G L HP D +KV LQTQ + + +++ R + +L
Sbjct: 1 MPVEEFVAGWISGALG----LVLGHPFDTVKVRLQTQTTYR-GIVDCMVKIYRHESLLGF 55
Query: 61 YSGLSASLCRQMTYSLTRFAIYE------TVRDRVAKGSQGPLPFHEKVLLGSVSGLAGG 114
+ G+S + + F +Y T + +Q P H L G G
Sbjct: 56 FKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMH-IFLAGCTGGFLQA 114
Query: 115 FVGTPADLVNVRMQNDVK---LPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRG 171
+ P DL+ VR+QN + P Y + + REEG R LF GA + R
Sbjct: 115 YCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRD 174
Query: 172 ALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNS- 230
Y+ + G + + T VA AG + PLD++K+R+
Sbjct: 175 TPTVGIYFITYEGLCRQYTPEGQ-NPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDG 233
Query: 231 --KGEYQGVFHCAVETAKLGPL-AFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFG 282
+ YQG+ C V + + L F++G+ R P +TF+ E L + +G
Sbjct: 234 LRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWWG 288
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 74.7 bits (182), Expect = 9e-14
Identities = 77/289 (26%), Positives = 122/289 (42%), Gaps = 24/289 (8%)
Query: 9 RWYFGGLASCGAACCTHPLDLLKVHLQTQQ-------EVKLRMT-GMALRVVRTDGILAL 60
R+ G +A A +P+DL+K +Q Q+ E+ + + +V+R +G L
Sbjct: 329 RFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGL 388
Query: 61 YSGLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPA 120
Y GL L + + + VRD+ + G +P +VL G +G + P
Sbjct: 389 YRGLIPQLIGVAPEKAIKLTVNDFVRDKFTR-RDGSVPLPAEVLAGGCAGGSQVIFTNPL 447
Query: 121 DLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLS 180
++V +R+Q ++ G R AL+ V R+ G+ L+ GA R +
Sbjct: 448 EIVKIRLQVAGEITTGPR---VSALN----VLRDLGIFGLYKGAKACFLRDIPFSAIYFP 500
Query: 181 CYDQAKQLVL-STGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLM----NSKGEYQ 235
Y K L+ G++ A +AG A L P DV+KTRL + Y
Sbjct: 501 VYAHCKLLLADENGHVGG--LNLLAAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYS 558
Query: 236 GVFHCAVETAK-LGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGI 283
GV C + + GP AF+KG R P +T V E L++ F I
Sbjct: 559 GVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWFYI 607
>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
sapiens]
Length = 477
Score = 73.2 bits (178), Expect = 3e-13
Identities = 53/197 (26%), Positives = 91/197 (46%), Gaps = 8/197 (4%)
Query: 84 TVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRNYAH 143
T+ D + + + ++L G ++G P D + + MQ G + + +
Sbjct: 179 TIPDEFTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQ-----VHGSKSDKMN 233
Query: 144 ALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHF 203
G ++ +E G+R L+ G + A T + Y+Q K+L+ G F F
Sbjct: 234 IFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQ-KIGTFERF 292
Query: 204 VASFIAGGCATFLCQPLDVLKTRLMNSK-GEYQGVFHCAVETAKLGPL-AFYKGLVPAGI 261
++ +AG A P++V+KTRL K G+Y G++ CA + K L AFYKG VP +
Sbjct: 293 ISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLL 352
Query: 262 RLIPHTVLTFVFLEQLR 278
+IP+ + E L+
Sbjct: 353 GIIPYAGIDLAVYELLK 369
Score = 60.5 bits (145), Expect = 2e-09
Identities = 61/297 (20%), Positives = 130/297 (43%), Gaps = 27/297 (9%)
Query: 4 EARVSRWY----FGGLASCGAACCTHPLDLLKVHLQT--QQEVKLRMTGMALRVVRTDGI 57
E + +W+ GG+A + T PLD LK+ +Q + K+ + G ++V+ GI
Sbjct: 188 EKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGI 247
Query: 58 LALYSGLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVG 117
+L+ G ++ + + +F YE + + + Q + E+ + GS++G
Sbjct: 248 RSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQ-KIGTFERFISGSMAGATAQTFI 306
Query: 118 TPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVG 177
P +++ R L G+ Y+ D ++ + EGL + G + + G + G
Sbjct: 307 YPMEVMKTR------LAVGKTGQYSGIYDCAKKILKHEGLGAFYKG-YVPNLLGIIPYAG 359
Query: 178 -QLSCYDQAKQLVL---STGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNS--- 230
L+ Y+ K L + ++ + ++ C PL +++TR+
Sbjct: 360 IDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAML 419
Query: 231 KGEYQ----GVFHCAVETAKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGI 283
+G Q G+F + +K G Y+G+ P ++++P +++V E +++ G+
Sbjct: 420 EGSPQLNMVGLFRRII--SKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGV 474
>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
Length = 458
Score = 73.2 bits (178), Expect = 3e-13
Identities = 53/197 (26%), Positives = 91/197 (46%), Gaps = 8/197 (4%)
Query: 84 TVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRNYAH 143
T+ D + + + ++L G ++G P D + + MQ G + + +
Sbjct: 160 TIPDEFTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQ-----VHGSKSDKMN 214
Query: 144 ALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHF 203
G ++ +E G+R L+ G + A T + Y+Q K+L+ G F F
Sbjct: 215 IFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQ-KIGTFERF 273
Query: 204 VASFIAGGCATFLCQPLDVLKTRLMNSK-GEYQGVFHCAVETAKLGPL-AFYKGLVPAGI 261
++ +AG A P++V+KTRL K G+Y G++ CA + K L AFYKG VP +
Sbjct: 274 ISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLL 333
Query: 262 RLIPHTVLTFVFLEQLR 278
+IP+ + E L+
Sbjct: 334 GIIPYAGIDLAVYELLK 350
Score = 60.5 bits (145), Expect = 2e-09
Identities = 61/297 (20%), Positives = 130/297 (43%), Gaps = 27/297 (9%)
Query: 4 EARVSRWY----FGGLASCGAACCTHPLDLLKVHLQT--QQEVKLRMTGMALRVVRTDGI 57
E + +W+ GG+A + T PLD LK+ +Q + K+ + G ++V+ GI
Sbjct: 169 EKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGI 228
Query: 58 LALYSGLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVG 117
+L+ G ++ + + +F YE + + + Q + E+ + GS++G
Sbjct: 229 RSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQ-KIGTFERFISGSMAGATAQTFI 287
Query: 118 TPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVG 177
P +++ R L G+ Y+ D ++ + EGL + G + + G + G
Sbjct: 288 YPMEVMKTR------LAVGKTGQYSGIYDCAKKILKHEGLGAFYKG-YVPNLLGIIPYAG 340
Query: 178 -QLSCYDQAKQLVL---STGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNS--- 230
L+ Y+ K L + ++ + ++ C PL +++TR+
Sbjct: 341 IDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAML 400
Query: 231 KGEYQ----GVFHCAVETAKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGI 283
+G Q G+F + +K G Y+G+ P ++++P +++V E +++ G+
Sbjct: 401 EGSPQLNMVGLFRRII--SKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGV 455
>gi|239755176 PREDICTED: similar to solute carrier family 25, member
25 isoform 2 [Homo sapiens]
Length = 469
Score = 72.4 bits (176), Expect = 4e-13
Identities = 66/284 (23%), Positives = 122/284 (42%), Gaps = 21/284 (7%)
Query: 13 GGLASCGAACCTHPLDLLKVHLQTQ--QEVKLRMTGMALRVVRTDGILALYSGLSASLCR 70
GG A + CT PLD LKV +Q + + + G +++R G +L+ G ++ +
Sbjct: 193 GGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGINVLK 252
Query: 71 QMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQND 130
S +F YE ++ R+ Q L HE+++ GS++G P +++ RM
Sbjct: 253 IAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM--- 308
Query: 131 VKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVG-QLSCYDQAKQLV 189
GQ Y+ LD R+ EG+ + G + + G + G L+ Y+ K
Sbjct: 309 ALRKTGQ---YSGMLDCARRILAREGVAAFYKGY-VPNMLGIIPYAGIDLAVYETLKNAW 364
Query: 190 L---STGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETA- 245
L + +F ++ C PL +++TR M ++ +G + +
Sbjct: 365 LQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTR-MQAQASIEGAPEVTMSSLF 423
Query: 246 -----KLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGIK 284
G Y+GL P +++IP +++V E L+ G++
Sbjct: 424 KHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQ 467
>gi|239755174 PREDICTED: similar to solute carrier family 25, member
25 isoform 1 [Homo sapiens]
Length = 503
Score = 72.4 bits (176), Expect = 4e-13
Identities = 66/284 (23%), Positives = 122/284 (42%), Gaps = 21/284 (7%)
Query: 13 GGLASCGAACCTHPLDLLKVHLQTQ--QEVKLRMTGMALRVVRTDGILALYSGLSASLCR 70
GG A + CT PLD LKV +Q + + + G +++R G +L+ G ++ +
Sbjct: 227 GGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGINVLK 286
Query: 71 QMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQND 130
S +F YE ++ R+ Q L HE+++ GS++G P +++ RM
Sbjct: 287 IAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM--- 342
Query: 131 VKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVG-QLSCYDQAKQLV 189
GQ Y+ LD R+ EG+ + G + + G + G L+ Y+ K
Sbjct: 343 ALRKTGQ---YSGMLDCARRILAREGVAAFYKGY-VPNMLGIIPYAGIDLAVYETLKNAW 398
Query: 190 L---STGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETA- 245
L + +F ++ C PL +++TR M ++ +G + +
Sbjct: 399 LQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTR-MQAQASIEGAPEVTMSSLF 457
Query: 246 -----KLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGIK 284
G Y+GL P +++IP +++V E L+ G++
Sbjct: 458 KHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQ 501
>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
sapiens]
Length = 489
Score = 72.4 bits (176), Expect = 4e-13
Identities = 66/284 (23%), Positives = 122/284 (42%), Gaps = 21/284 (7%)
Query: 13 GGLASCGAACCTHPLDLLKVHLQTQ--QEVKLRMTGMALRVVRTDGILALYSGLSASLCR 70
GG A + CT PLD LKV +Q + + + G +++R G +L+ G ++ +
Sbjct: 213 GGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGINVLK 272
Query: 71 QMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQND 130
S +F YE ++ R+ Q L HE+++ GS++G P +++ RM
Sbjct: 273 IAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM--- 328
Query: 131 VKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVG-QLSCYDQAKQLV 189
GQ Y+ LD R+ EG+ + G + + G + G L+ Y+ K
Sbjct: 329 ALRKTGQ---YSGMLDCARRILAREGVAAFYKGY-VPNMLGIIPYAGIDLAVYETLKNAW 384
Query: 190 L---STGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETA- 245
L + +F ++ C PL +++TR M ++ +G + +
Sbjct: 385 LQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTR-MQAQASIEGAPEVTMSSLF 443
Query: 246 -----KLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGIK 284
G Y+GL P +++IP +++V E L+ G++
Sbjct: 444 KHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQ 487
>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
sapiens]
Length = 469
Score = 72.4 bits (176), Expect = 4e-13
Identities = 66/284 (23%), Positives = 122/284 (42%), Gaps = 21/284 (7%)
Query: 13 GGLASCGAACCTHPLDLLKVHLQTQ--QEVKLRMTGMALRVVRTDGILALYSGLSASLCR 70
GG A + CT PLD LKV +Q + + + G +++R G +L+ G ++ +
Sbjct: 193 GGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGINVLK 252
Query: 71 QMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQND 130
S +F YE ++ R+ Q L HE+++ GS++G P +++ RM
Sbjct: 253 IAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM--- 308
Query: 131 VKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVG-QLSCYDQAKQLV 189
GQ Y+ LD R+ EG+ + G + + G + G L+ Y+ K
Sbjct: 309 ALRKTGQ---YSGMLDCARRILAREGVAAFYKGY-VPNMLGIIPYAGIDLAVYETLKNAW 364
Query: 190 L---STGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETA- 245
L + +F ++ C PL +++TR M ++ +G + +
Sbjct: 365 LQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTR-MQAQASIEGAPEVTMSSLF 423
Query: 246 -----KLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGIK 284
G Y+GL P +++IP +++V E L+ G++
Sbjct: 424 KHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQ 467
>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
sapiens]
Length = 366
Score = 72.4 bits (176), Expect = 4e-13
Identities = 66/284 (23%), Positives = 122/284 (42%), Gaps = 21/284 (7%)
Query: 13 GGLASCGAACCTHPLDLLKVHLQTQ--QEVKLRMTGMALRVVRTDGILALYSGLSASLCR 70
GG A + CT PLD LKV +Q + + + G +++R G +L+ G ++ +
Sbjct: 90 GGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGINVLK 149
Query: 71 QMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQND 130
S +F YE ++ R+ Q L HE+++ GS++G P +++ RM
Sbjct: 150 IAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM--- 205
Query: 131 VKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVG-QLSCYDQAKQLV 189
GQ Y+ LD R+ EG+ + G + + G + G L+ Y+ K
Sbjct: 206 ALRKTGQ---YSGMLDCARRILAREGVAAFYKGY-VPNMLGIIPYAGIDLAVYETLKNAW 261
Query: 190 L---STGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETA- 245
L + +F ++ C PL +++TR M ++ +G + +
Sbjct: 262 LQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTR-MQAQASIEGAPEVTMSSLF 320
Query: 246 -----KLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGIK 284
G Y+GL P +++IP +++V E L+ G++
Sbjct: 321 KHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQ 364
>gi|56699403 solute carrier family 25, member 25 isoform b [Homo
sapiens]
Length = 503
Score = 72.4 bits (176), Expect = 4e-13
Identities = 66/284 (23%), Positives = 122/284 (42%), Gaps = 21/284 (7%)
Query: 13 GGLASCGAACCTHPLDLLKVHLQTQ--QEVKLRMTGMALRVVRTDGILALYSGLSASLCR 70
GG A + CT PLD LKV +Q + + + G +++R G +L+ G ++ +
Sbjct: 227 GGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGINVLK 286
Query: 71 QMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQND 130
S +F YE ++ R+ Q L HE+++ GS++G P +++ RM
Sbjct: 287 IAPESAIKFMAYEQIK-RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM--- 342
Query: 131 VKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVG-QLSCYDQAKQLV 189
GQ Y+ LD R+ EG+ + G + + G + G L+ Y+ K
Sbjct: 343 ALRKTGQ---YSGMLDCARRILAREGVAAFYKGY-VPNMLGIIPYAGIDLAVYETLKNAW 398
Query: 190 L---STGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETA- 245
L + +F ++ C PL +++TR M ++ +G + +
Sbjct: 399 LQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTR-MQAQASIEGAPEVTMSSLF 457
Query: 246 -----KLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGIK 284
G Y+GL P +++IP +++V E L+ G++
Sbjct: 458 KHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQ 501
>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
sapiens]
Length = 675
Score = 71.6 bits (174), Expect = 7e-13
Identities = 77/294 (26%), Positives = 118/294 (40%), Gaps = 34/294 (11%)
Query: 9 RWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMAL-------------RVVRTD 55
R+ G +A A +P+DL+K +Q Q R TG + +V+R +
Sbjct: 331 RFGLGSVAGAVGATAVYPIDLVKTRMQNQ-----RSTGSFVGELMYKNSFDCFKKVLRYE 385
Query: 56 GILALYSGLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGF 115
G LY GL L + + + VRD+ G +P ++L G +G +
Sbjct: 386 GFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMH-KDGSVPLAAEILAGGCAGGSQVI 444
Query: 116 VGTPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVT 175
P ++V +R+Q ++ G R AL V R+ G ++ GA R +
Sbjct: 445 FTNPLEIVKIRLQVAGEITTGPR---VSALS----VVRDLGFFGIYKGAKACFLRDIPFS 497
Query: 176 VGQLSCYDQAK-QLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLM----NS 230
CY K G +S + +A IAG A L P DV+KTRL
Sbjct: 498 AIYFPCYAHVKASFANEDGQVSPG--SLLLAGAIAGMPAASLVTPADVIKTRLQVAARAG 555
Query: 231 KGEYQGVFHCAVETAK-LGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGI 283
+ Y GV C + + GP A +KG R P +T + E L++ F I
Sbjct: 556 QTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQRWFYI 609
>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
sapiens]
Length = 676
Score = 71.6 bits (174), Expect = 7e-13
Identities = 77/294 (26%), Positives = 118/294 (40%), Gaps = 34/294 (11%)
Query: 9 RWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMAL-------------RVVRTD 55
R+ G +A A +P+DL+K +Q Q R TG + +V+R +
Sbjct: 332 RFGLGSVAGAVGATAVYPIDLVKTRMQNQ-----RSTGSFVGELMYKNSFDCFKKVLRYE 386
Query: 56 GILALYSGLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGF 115
G LY GL L + + + VRD+ G +P ++L G +G +
Sbjct: 387 GFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMH-KDGSVPLAAEILAGGCAGGSQVI 445
Query: 116 VGTPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVT 175
P ++V +R+Q ++ G R AL V R+ G ++ GA R +
Sbjct: 446 FTNPLEIVKIRLQVAGEITTGPR---VSALS----VVRDLGFFGIYKGAKACFLRDIPFS 498
Query: 176 VGQLSCYDQAK-QLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLM----NS 230
CY K G +S + +A IAG A L P DV+KTRL
Sbjct: 499 AIYFPCYAHVKASFANEDGQVSPG--SLLLAGAIAGMPAASLVTPADVIKTRLQVAARAG 556
Query: 231 KGEYQGVFHCAVETAK-LGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGI 283
+ Y GV C + + GP A +KG R P +T + E L++ F I
Sbjct: 557 QTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQRWFYI 610
>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
Length = 468
Score = 71.6 bits (174), Expect = 7e-13
Identities = 55/197 (27%), Positives = 95/197 (48%), Gaps = 8/197 (4%)
Query: 84 TVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRNYAH 143
TV D +K + + ++++ G+V+G P D + V MQ + N +
Sbjct: 170 TVPDEFSKQEKLTGMWWKQLVAGAVAGAVSRTGTAPLDRLKVFMQ-----VHASKTNRLN 224
Query: 144 ALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHF 203
L GL + E G+R L+ G + + A + + Y+Q K+ +L ++ F
Sbjct: 225 ILGGLRSMVLEGGIRSLWRGNGINVLKIAPESAIKFMAYEQIKRAILGQQETL-HVQERF 283
Query: 204 VASFIAGGCATFLCQPLDVLKTRL-MNSKGEYQGVFHCAVE-TAKLGPLAFYKGLVPAGI 261
VA +AG A + P++VLKTRL + G+Y+G+ CA + GP AFY+G +P +
Sbjct: 284 VAGSLAGATAQTIIYPMEVLKTRLTLRRTGQYKGLLDCARRILEREGPRAFYRGYLPNVL 343
Query: 262 RLIPHTVLTFVFLEQLR 278
+IP+ + E L+
Sbjct: 344 GIIPYAGIDLAVYETLK 360
Score = 62.8 bits (151), Expect = 3e-10
Identities = 66/284 (23%), Positives = 120/284 (42%), Gaps = 23/284 (8%)
Query: 13 GGLASCGAACCTHPLDLLKVHLQTQQEV--KLRMTGMALRVVRTDGILALYSGLSASLCR 70
G +A + T PLD LKV +Q +L + G +V GI +L+ G ++ +
Sbjct: 192 GAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNILGGLRSMVLEGGIRSLWRGNGINVLK 251
Query: 71 QMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQND 130
S +F YE ++ R G Q L E+ + GS++G + P +++ R
Sbjct: 252 IAPESAIKFMAYEQIK-RAILGQQETLHVQERFVAGSLAGATAQTIIYPMEVLKTR---- 306
Query: 131 VKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVG-QLSCYDQAKQLV 189
L + Y LD R+ EG R + G + + G + G L+ Y+ K
Sbjct: 307 --LTLRRTGQYKGLLDCARRILEREGPRAFYRGY-LPNVLGIIPYAGIDLAVYETLKNWW 363
Query: 190 LSTGYLSDN----IFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAVE-- 243
L Y D+ I I+ C PL +++TR M ++ +G ++
Sbjct: 364 LQQ-YSHDSADPGILVLLACGTISSTCGQIASYPLALVRTR-MQAQASIEGGPQLSMLGL 421
Query: 244 ----TAKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGI 283
++ G Y+G+ P +++IP +++V E +++ G+
Sbjct: 422 LRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMKQALGV 465
Score = 34.3 bits (77), Expect = 0.13
Identities = 17/86 (19%), Positives = 42/86 (48%), Gaps = 4/86 (4%)
Query: 13 GGLASCGAACCTHPLDLLKVHLQTQQEVK----LRMTGMALRVVRTDGILALYSGLSASL 68
G ++S ++PL L++ +Q Q ++ L M G+ ++ +G+ LY G++ +
Sbjct: 383 GTISSTCGQIASYPLALVRTRMQAQASIEGGPQLSMLGLLRHILSQEGMRGLYRGIAPNF 442
Query: 69 CRQMTYSLTRFAIYETVRDRVAKGSQ 94
+ + + +YE ++ + S+
Sbjct: 443 MKVIPAVSISYVVYENMKQALGVTSR 468
>gi|41462412 solute carrier family 25, member 35 [Homo sapiens]
Length = 295
Score = 70.5 bits (171), Expect = 2e-12
Identities = 58/239 (24%), Positives = 101/239 (42%), Gaps = 19/239 (7%)
Query: 14 GLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMA---------LRVVRTDGILALYSGL 64
GLA+CGA T+PL+++K +Q Q E++ T + + + DG+ AL GL
Sbjct: 7 GLAACGACVFTNPLEVVKTRMQLQGELQAPGTYQRHYRNVFHAFITIGKVDGLAALQKGL 66
Query: 65 SASLCRQMTYSLTRFAIYETVRD----RVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPA 120
+ +L Q + R Y A+G+ P G+++G+ G ++G+P
Sbjct: 67 APALLYQFLMNGIRLGTYGLAEAGGYLHTAEGTHSPA---RSAAAGAMAGVMGAYLGSPI 123
Query: 121 DLVNVRMQNDV--KLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQ 178
+V +Q ++ G + + L + ++ GL L+ GA R + + Q
Sbjct: 124 YMVKTHLQAQAASEIAVGHQYKHQGMFQALTEIGQKHGLVGLWRGALGGLPRVIVGSSTQ 183
Query: 179 LSCYDQAKQLVLSTGYLSDNIF-THFVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQG 236
L + K L+ + VA+ ++G P DV TRL N + QG
Sbjct: 184 LCTFSSTKDLLSQWEIFPPQSWKLALVAAMMSGIAVVLAMAPFDVACTRLYNQPTDAQG 242
Score = 32.7 bits (73), Expect = 0.38
Identities = 25/68 (36%), Positives = 33/68 (48%), Gaps = 12/68 (17%)
Query: 203 FVASFIAGGCATFLCQPLDVLKTRLMNSKGE----------YQGVFHCAVETAKL-GPLA 251
F+ S +A A PL+V+KTR M +GE Y+ VFH + K+ G A
Sbjct: 3 FLMSGLAACGACVFTNPLEVVKTR-MQLQGELQAPGTYQRHYRNVFHAFITIGKVDGLAA 61
Query: 252 FYKGLVPA 259
KGL PA
Sbjct: 62 LQKGLAPA 69
>gi|60460887 solute carrier family 25, member 42 [Homo sapiens]
Length = 318
Score = 68.9 bits (167), Expect = 5e-12
Identities = 53/179 (29%), Positives = 89/179 (49%), Gaps = 9/179 (5%)
Query: 9 RWYFGGLASCGAACCTHPLDLLKVHLQ-TQQEVKLRMTGMALRVVRTDGILALYSGLSAS 67
R + G LA AA T+PLDL++ + T +E+ + + +R+ R +G+ LY G +
Sbjct: 134 RLFAGALAGTTAASLTYPLDLVRARMAVTPKEMYSNIFHVFIRISREEGLKTLYHGFMPT 193
Query: 68 LCRQMTYSLTRFAIYETVRD--RVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNV 125
+ + Y+ F YET++ R G + P PF E+++ G+ +GL G P D+V
Sbjct: 194 VLGVIPYAGLSFFTYETLKSLHREYSGRRQPYPF-ERMIFGACAGLIGQSASYPLDVVRR 252
Query: 126 RMQNDVKLPQGQRRNYAHALDGLYRVAREEG-LRRLFSGATMASSRGALVTVGQLSCYD 183
RMQ + R + A L + REEG +R L+ G +M +G + + +D
Sbjct: 253 RMQT-AGVTGYPRASIART---LRTIVREEGAVRGLYKGLSMNWVKGPIAVGISFTTFD 307
Score = 47.8 bits (112), Expect = 1e-05
Identities = 49/188 (26%), Positives = 81/188 (43%), Gaps = 14/188 (7%)
Query: 100 HEKVLLGSVSG-LAGGFVGT---PADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREE 155
H +VL + G LAG T P D + Q K R + A LY E
Sbjct: 30 HRQVLSSLLPGALAGALAKTAVAPLDRTKIIFQVSSK-----RFSAKEAFRVLYYTYLNE 84
Query: 156 GLRRLFSGATMASSRGALVTVGQLSCYDQAKQLVLST-GYLSDNI--FTHFVASFIAGGC 212
G L+ G + R Q S +++ K+++ S G+ + + + A +AG
Sbjct: 85 GFLSLWRGNSATMVRVVPYAAIQFSAHEEYKRILGSYYGFRGEALPPWPRLFAGALAGTT 144
Query: 213 ATFLCQPLDVLKTRL-MNSKGEYQGVFHCAVETAKL-GPLAFYKGLVPAGIRLIPHTVLT 270
A L PLD+++ R+ + K Y +FH + ++ G Y G +P + +IP+ L+
Sbjct: 145 AASLTYPLDLVRARMAVTPKEMYSNIFHVFIRISREEGLKTLYHGFMPTVLGVIPYAGLS 204
Query: 271 FVFLEQLR 278
F E L+
Sbjct: 205 FFTYETLK 212
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.138 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,686,092
Number of Sequences: 37866
Number of extensions: 396780
Number of successful extensions: 1433
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1000
Number of HSP's gapped (non-prelim): 185
length of query: 287
length of database: 18,247,518
effective HSP length: 101
effective length of query: 186
effective length of database: 14,423,052
effective search space: 2682687672
effective search space used: 2682687672
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.