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Search of human proteins with 20128768
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20128768 serine/threonine kinase 35 [Homo sapiens]
(401 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20128768 serine/threonine kinase 35 [Homo sapiens] 805 0.0
gi|22779870 PDLIM1 interacting kinase 1 like [Homo sapiens] 460 e-130
gi|23943882 serine/threonine kinase 33 [Homo sapiens] 96 4e-20
gi|150456432 unc-51-like kinase 3 [Homo sapiens] 89 7e-18
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 88 1e-17
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 87 3e-17
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 87 3e-17
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 85 1e-16
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 84 3e-16
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 84 3e-16
gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Ho... 83 5e-16
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 83 5e-16
gi|29826329 p21-activated kinase 7 [Homo sapiens] 82 9e-16
gi|24308191 p21-activated kinase 7 [Homo sapiens] 82 9e-16
gi|191252782 p21-activated kinase 6 [Homo sapiens] 82 1e-15
gi|191252780 p21-activated kinase 6 [Homo sapiens] 82 1e-15
gi|9910476 p21-activated kinase 6 [Homo sapiens] 82 1e-15
gi|217330559 unc-51-like kinase 2 [Homo sapiens] 81 2e-15
gi|217330557 unc-51-like kinase 2 [Homo sapiens] 81 2e-15
gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens] 81 2e-15
gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens] 81 2e-15
gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens] 81 2e-15
gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens] 81 2e-15
gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens] 81 2e-15
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 80 2e-15
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 80 2e-15
gi|148727255 microtubule associated serine/threonine kinase fami... 80 3e-15
gi|156105707 SNF related kinase [Homo sapiens] 79 6e-15
gi|156105705 SNF related kinase [Homo sapiens] 79 6e-15
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 79 6e-15
>gi|20128768 serine/threonine kinase 35 [Homo sapiens]
Length = 401
Score = 805 bits (2080), Expect = 0.0
Identities = 401/401 (100%), Positives = 401/401 (100%)
Query: 1 METGKDGARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEG 60
METGKDGARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEG
Sbjct: 1 METGKDGARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEG 60
Query: 61 GGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTS 120
GGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTS
Sbjct: 61 GGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTS 120
Query: 121 LKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWF 180
LKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWF
Sbjct: 121 LKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWF 180
Query: 181 VMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSG 240
VMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSG
Sbjct: 181 VMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSG 240
Query: 241 TPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHYTA 300
TPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHYTA
Sbjct: 241 TPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHYTA 300
Query: 301 KADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQK 360
KADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQK
Sbjct: 301 KADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQK 360
Query: 361 RRTSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQVTCAA 401
RRTSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQVTCAA
Sbjct: 361 RRTSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQVTCAA 401
>gi|22779870 PDLIM1 interacting kinase 1 like [Homo sapiens]
Length = 341
Score = 460 bits (1184), Expect = e-130
Identities = 235/339 (69%), Positives = 283/339 (83%), Gaps = 14/339 (4%)
Query: 64 SARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLKR 123
S++P+Y L+ E+GRGSYGVVYEAV ++ ARVAVKKIRC APENVELAL EFWAL+S+K
Sbjct: 3 SSQPKYDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPENVELALREFWALSSIKS 62
Query: 124 RHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVME 183
+H NV+ EEC+LQ++G+ Q+MSHG+ SS LYL+LVETSLKGE I YLWFVM+
Sbjct: 63 QHPNVIHLEECILQKDGMVQKMSHGSNSS-LYLQLVETSLKGE-IAFDPRSAYYLWFVMD 120
Query: 184 FCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITE-RSGT- 241
FC+GGD+N+Y+LSR+P+ TN SFMLQL+SA+AFLHKN I+HRDLKPDNILI++ R T
Sbjct: 121 FCDGGDMNEYLLSRKPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTS 180
Query: 242 ---PILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHY 298
P LKVADFGLSKVC+ G + V+VNK +LS+ACG+DFYMAPEVWEGHY
Sbjct: 181 DLEPTLKVADFGLSKVCSA------SGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEGHY 234
Query: 299 TAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIP 358
TAKADIFALGIIIWAM+ERITFID+ETKKELLG+Y+KQGTEIVPVGEALLENPKMEL IP
Sbjct: 235 TAKADIFALGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLIP 294
Query: 359 QKRRTSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQV 397
K++ SM+ +KQL+K+MLAANPQDRPDAFELE R+ Q+
Sbjct: 295 VKKK-SMNGRMKQLIKEMLAANPQDRPDAFELELRLVQI 332
>gi|23943882 serine/threonine kinase 33 [Homo sapiens]
Length = 514
Score = 96.3 bits (238), Expect = 4e-20
Identities = 100/404 (24%), Positives = 171/404 (42%), Gaps = 87/404 (21%)
Query: 2 ETGKDGARRGTQSPERKRRSPVPR-APSTKLRPAAAARAMDPVAAEAPGEA-FLARRRPE 59
+T G+ S ERK+ + R S K P+ + + + G F + P
Sbjct: 44 QTSSIGSAESLISLERKKEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVPH 103
Query: 60 ---GGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFW 116
G + Y+ +G+GS+G+V EA + + A+KK+ + + + L E
Sbjct: 104 IRIENGAAIEEIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLERE 163
Query: 117 ALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPC 176
+H++++ E+ E P
Sbjct: 164 VNILKSVKHEHIIHLEQVF-------------------------------------ETPK 186
Query: 177 YLWFVMEFCEGGDLNQYVLSRRPDPATNKS--FMLQLTSAIAFLHKNHIVHRDLKPDNI- 233
++ VME CE G+L + +L R+ + N++ + L SAIA+LH N IVHRDLK +NI
Sbjct: 187 KMYLVMELCEDGELKE-ILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIM 245
Query: 234 ----LITERSGTPI-LKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFY 288
LI + + + +KV DFGL+ K + ++ L + CG+ Y
Sbjct: 246 VKSSLIDDNNEINLNIKVTDFGLAV----------------KKQSRSEAMLQATCGTPIY 289
Query: 289 MAPEVWEGH-YTAKADIFALGIIIWAMIE-RITFIDSETKKELLGTYIKQGTEIVPVGEA 346
MAPEV H Y+ + DI+++G++++ ++ F+ S +K L I++G
Sbjct: 290 MAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEK--LFELIRKG--------- 338
Query: 347 LLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAFEL 390
ELH S+S+ K +LK ++ +P R A EL
Sbjct: 339 -------ELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKEL 375
>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
Length = 472
Score = 89.0 bits (219), Expect = 7e-18
Identities = 81/262 (30%), Positives = 122/262 (46%), Gaps = 70/262 (26%)
Query: 61 GGGSARPR---YSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPEN-----VELAL 112
G G PR + L +G G+Y VY+A A + V I+C A ++ VE L
Sbjct: 3 GPGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVA--IKCVAKKSLNKASVENLL 60
Query: 113 AEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYA 172
E L + RH ++VQ ++ S +YL
Sbjct: 61 TEIEILKGI--RHPHIVQLKDFQWD-------------SDNIYL---------------- 89
Query: 173 EEPCYLWFVMEFCEGGDLNQYVLSRRPDPA-TNKSFMLQLTSAIAFLHKNHIVHRDLKPD 231
+MEFC GGDL++++ +RR P + FM QL SA+ FLH+ +I H DLKP
Sbjct: 90 --------IMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQ 141
Query: 232 NILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAP 291
NIL++ P LK+ADFG ++ ++P D K+V GS YMAP
Sbjct: 142 NILLSSLE-KPHLKLADFGFAQ---HMSP------WDEKHV---------LRGSPLYMAP 182
Query: 292 E-VWEGHYTAKADIFALGIIIW 312
E V + Y A+ D++++G+I++
Sbjct: 183 EMVCQRQYDARVDLWSMGVILY 204
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 88.2 bits (217), Expect = 1e-17
Identities = 75/275 (27%), Positives = 124/275 (45%), Gaps = 48/275 (17%)
Query: 122 KRRHQNVVQFEECV--LQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLW 179
K RH+ E V + + LA+ + K ++ L ++ + + E ++
Sbjct: 32 KGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVA--LYDFQEMANSVY 89
Query: 180 FVMEFCEGGDLNQYVLSRRP-DPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITER 238
VME+C GGDL Y+ + R T + F+ Q+ A+ LH I+HRDLKP NIL++
Sbjct: 90 LVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNP 149
Query: 239 SGTPI------LKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPE 292
+G +K+ADFG ++ + ++ CGS YMAPE
Sbjct: 150 AGRRANPNSIRVKIADFGFARYLQ------------------SNMMAATLCGSPMYMAPE 191
Query: 293 V-WEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENP 351
V HY KAD++++G I++ + + + ++L Y K T +VP
Sbjct: 192 VIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKT-LVPT-------- 242
Query: 352 KMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPD 386
IP++ S ++QLL +L N +DR D
Sbjct: 243 -----IPRE----TSAPLRQLLLALLQRNHKDRMD 268
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 87.0 bits (214), Expect = 3e-17
Identities = 102/381 (26%), Positives = 158/381 (41%), Gaps = 88/381 (23%)
Query: 17 RKRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEGG---GGSARPRYSLLA 73
RK+RS ST L +MD + PGE E G + RY +
Sbjct: 342 RKQRSSQHGGSSTSLASTKVCSSMDE--NDGPGEEV-----SEEGFQIPATITERYKVGR 394
Query: 74 EIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEE 133
IG G++ VV E V + A+K I+ S R ++++Q E
Sbjct: 395 TIGDGNFAVVKECVERSTAREYALKIIK-----------------KSKCRGKEHMIQNEV 437
Query: 134 CVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQY 193
+L+R + H N + L+E + P L+ VME +GGDL
Sbjct: 438 SILRR------VKHPN-----IVLLIEEM----------DVPTELYLVMELVKGGDLFDA 476
Query: 194 VLSRRPDPATNKSFML-QLTSAIAFLHKNHIVHRDLKPDNILITE-RSGTPILKVADFGL 251
+ S + S ML L SAI +LH +IVHRD+KP+N+L+ E + G+ LK+ DFGL
Sbjct: 477 ITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGL 536
Query: 252 SKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPE-VWEGHYTAKADIFALGII 310
+ + G L + CG+ Y+APE + E Y K DI+A G+I
Sbjct: 537 ATIVDGP--------------------LYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVI 576
Query: 311 IWAMIERI-TFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGI 369
+ ++ F S +E+L I G ++ P ++S+
Sbjct: 577 TYILLCGFPPFRGSGDDQEVLFDQILMG----------------QVDFPSPYWDNVSDSA 620
Query: 370 KQLLKDMLAANPQDRPDAFEL 390
K+L+ ML + R A ++
Sbjct: 621 KELITMMLLVDVDQRFSAVQV 641
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 86.7 bits (213), Expect = 3e-17
Identities = 77/321 (23%), Positives = 132/321 (41%), Gaps = 80/321 (24%)
Query: 69 YSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNV 128
Y L +G+GSYG V R G + +KK+ + E AE A + +H N+
Sbjct: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Query: 129 VQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGG 188
V ++E +GL L+ VM FCEGG
Sbjct: 66 VTYKESWEGGDGL------------------------------------LYIVMGFCEGG 89
Query: 189 DLNQYVLSRRPDPATNKS---FMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILK 245
DL + + ++ + +Q+ A+ +LH+ HI+HRDLK N+ +T T I+K
Sbjct: 90 DLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTR---TNIIK 146
Query: 246 VADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGH-YTAKADI 304
V D G+++V E + D S+ G+ +YM+PE++ Y K+D+
Sbjct: 147 VGDLGIARVL--------ENHCD---------MASTLIGTPYYMSPELFSNKPYNYKSDV 189
Query: 305 FALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTS 364
+ALG ++ M +++ L+ I+ +P
Sbjct: 190 WALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMP--------------------RD 229
Query: 365 MSEGIKQLLKDMLAANPQDRP 385
S + +L++ ML+ P++RP
Sbjct: 230 YSPELAELIRTMLSKRPEERP 250
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 85.1 bits (209), Expect = 1e-16
Identities = 53/173 (30%), Positives = 92/173 (53%), Gaps = 25/173 (14%)
Query: 173 EEPCYLWFVMEFCEGGDLNQYVLSR-RPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPD 231
E YL+ V+E GG+L Y++ + R P + F Q+ SA+ F H + I HRDLKP+
Sbjct: 86 ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPE 145
Query: 232 NILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAP 291
N+L+ E++ +++ADFG++ ++ V L ++CGS Y P
Sbjct: 146 NLLLDEKNN---IRIADFGMA------------------SLQVGDSLLETSCGSPHYACP 184
Query: 292 EVWEG--HYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVP 342
EV G + KAD+++ G+I++A++ D + ++LL +K+G +P
Sbjct: 185 EVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLL-EKVKRGVFHMP 236
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 83.6 bits (205), Expect = 3e-16
Identities = 84/328 (25%), Positives = 137/328 (41%), Gaps = 69/328 (21%)
Query: 69 YSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAP-ENV-ELALAEFWALTSLKRRHQ 126
+ + +IG G+YGVVY+A +G VA+KKIR D E V A+ E L LK H
Sbjct: 4 FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELK--HP 61
Query: 127 NVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCE 186
N+V+ + V H + L + LK M+
Sbjct: 62 NIVRLLDVV-----------HNERKLYLVFEFLSQDLKK---------------YMDSTP 95
Query: 187 GGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKV 246
G +L +++ KS++ QL ++F H + ++HRDLKP N+LI E +K+
Sbjct: 96 GSELPLHLI---------KSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGA---IKL 143
Query: 247 ADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEG--HYTAKADI 304
ADFGL++ V + Y + + +Y APE+ G YT DI
Sbjct: 144 ADFGLARAF---------------GVPLRTY--THEVVTLWYRAPEILLGSKFYTTAVDI 186
Query: 305 FALGIIIWAMIERITFIDSETK-KELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRT 363
+++G I M+ R +++ +L + GT + + P + P+ R
Sbjct: 187 WSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRK 246
Query: 364 SMSEGI-------KQLLKDMLAANPQDR 384
+ E + + LL +L +P R
Sbjct: 247 GLEEIVPNLEPEGRDLLMQLLQYDPSQR 274
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 83.6 bits (205), Expect = 3e-16
Identities = 76/300 (25%), Positives = 124/300 (41%), Gaps = 71/300 (23%)
Query: 42 PVAAEAPGEAFLARRRPEG-----GGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVA 96
P A A A L R+P G + + RY L +G+G+YG V A SG VA
Sbjct: 23 PREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVA 82
Query: 97 VKKIRCDAPENVELAL---AEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQ 153
+K IR D ++ + + E ++SL H +++ E ++ +
Sbjct: 83 IKSIRKDKIKDEQDMVHIRREIEIMSSLN--HPHIISIYEVFENKDKIV----------- 129
Query: 154 LYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRP-DPATNKSFMLQLT 212
+ME+ G+L Y+ RR + F Q+
Sbjct: 130 --------------------------IIMEYASKGELYDYISERRRLSERETRHFFRQIV 163
Query: 213 SAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNV 272
SA+ + HKN +VHRDLK +NIL+ + +K+ADFGLS N+
Sbjct: 164 SAVHYCHKNGVVHRDLKLENILLDDNCN---IKIADFGLS------------------NL 202
Query: 273 NVNKYWLSSACGSDFYMAPEVWEG--HYTAKADIFALGIIIWAMIERITFIDSETKKELL 330
+L + CGS Y +PE+ G + + D +ALG++++ ++ D K L+
Sbjct: 203 YQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLI 262
>gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Homo
sapiens]
Length = 1288
Score = 82.8 bits (203), Expect = 5e-16
Identities = 72/252 (28%), Positives = 109/252 (43%), Gaps = 75/252 (29%)
Query: 75 IGRGSYGVVYEAVAGRSGARVAVKKI-----RCDAPENVELALAEFWALTSLKRRHQNVV 129
+G+G+YGVVY + R+A+K+I R P + E+AL + RH+N+V
Sbjct: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHR-------RLRHKNIV 706
Query: 130 QFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGD 189
++ LG A + YL ME GG
Sbjct: 707 RY-------------------------------------LGSASQGGYLKIFMEEVPGGS 729
Query: 190 LNQYVLS----RRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILK 245
L+ + S + + +T + Q+ + +LH NHIVHRD+K DN+LI SG +LK
Sbjct: 730 LSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSG--LLK 787
Query: 246 VADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWE---GHYTAKA 302
++DFG SK AG+ P + G+ YMAPE+ + Y A
Sbjct: 788 ISDFGTSKRLAGITP-----------------CTETFTGTLQYMAPEIIDQGPRGYGKAA 830
Query: 303 DIFALGIIIWAM 314
DI++LG + M
Sbjct: 831 DIWSLGCTVIEM 842
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 82.8 bits (203), Expect = 5e-16
Identities = 52/173 (30%), Positives = 92/173 (53%), Gaps = 25/173 (14%)
Query: 173 EEPCYLWFVMEFCEGGDLNQYVLSR-RPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPD 231
E YL+ V+E GG+L Y++ + R P + F Q+ SA+ F H I HRDLKP+
Sbjct: 101 ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPE 160
Query: 232 NILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAP 291
N+L+ E++ +++ADFG++ ++ V L ++CGS Y P
Sbjct: 161 NLLLDEKNN---IRIADFGMA------------------SLQVGDSLLETSCGSPHYACP 199
Query: 292 EVWEG--HYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVP 342
EV +G + +AD+++ G+I++A++ D + ++LL +K+G +P
Sbjct: 200 EVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLL-EKVKRGVFHMP 251
>gi|29826329 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 82.0 bits (201), Expect = 9e-16
Identities = 79/290 (27%), Positives = 125/290 (43%), Gaps = 60/290 (20%)
Query: 28 STKLRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAV 87
S+ P + + D + E F A + G R + +IG GS G+V A
Sbjct: 408 SSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIAT 467
Query: 88 AGRSGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSH 147
+G +VAVKK+ L+++ + + F E V+ R+ H
Sbjct: 468 EKHTGKQVAVKKM-------------------DLRKQQRRELLFNEVVIMRD------YH 502
Query: 148 GNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSF 207
+ +Y + L G+ LW VMEF EGG L V R + +
Sbjct: 503 HDNVVDMY----SSYLVGDE----------LWVVMEFLEGGALTDIVTHTRMNEEQIATV 548
Query: 208 MLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQ 267
L + A+++LH ++HRD+K D+IL+T +K++DFG CA Q
Sbjct: 549 CLSVLRALSYLHNQGVIHRDIKSDSILLTSDGR---IKLSDFGF---CA----------Q 592
Query: 268 DNKNVNVNKYWLSSACGSDFYMAPEVWEG-HYTAKADIFALGIIIWAMIE 316
+K V K S G+ ++MAPEV Y + DI++LGI++ MI+
Sbjct: 593 VSKEVPKRK----SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMID 638
>gi|24308191 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 82.0 bits (201), Expect = 9e-16
Identities = 79/290 (27%), Positives = 125/290 (43%), Gaps = 60/290 (20%)
Query: 28 STKLRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAV 87
S+ P + + D + E F A + G R + +IG GS G+V A
Sbjct: 408 SSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIAT 467
Query: 88 AGRSGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSH 147
+G +VAVKK+ L+++ + + F E V+ R+ H
Sbjct: 468 EKHTGKQVAVKKM-------------------DLRKQQRRELLFNEVVIMRD------YH 502
Query: 148 GNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSF 207
+ +Y + L G+ LW VMEF EGG L V R + +
Sbjct: 503 HDNVVDMY----SSYLVGDE----------LWVVMEFLEGGALTDIVTHTRMNEEQIATV 548
Query: 208 MLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQ 267
L + A+++LH ++HRD+K D+IL+T +K++DFG CA Q
Sbjct: 549 CLSVLRALSYLHNQGVIHRDIKSDSILLTSDGR---IKLSDFGF---CA----------Q 592
Query: 268 DNKNVNVNKYWLSSACGSDFYMAPEVWEG-HYTAKADIFALGIIIWAMIE 316
+K V K S G+ ++MAPEV Y + DI++LGI++ MI+
Sbjct: 593 VSKEVPKRK----SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMID 638
>gi|191252782 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 81.6 bits (200), Expect = 1e-15
Identities = 102/391 (26%), Positives = 158/391 (40%), Gaps = 92/391 (23%)
Query: 13 QSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAP----------GEAFLARRRPEGGG 62
Q P R + PR ++ + DP A+ E F A R
Sbjct: 341 QLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQ 400
Query: 63 GSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLK 122
G R +IG GS G+V A SG +VAVK + L+
Sbjct: 401 GDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVK-------------------MMDLR 441
Query: 123 RRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVM 182
++ + + F E V+ R+ H N + + ++ L GE LW +M
Sbjct: 442 KQQRRELLFNEVVIMRD-----YQHFN-----VVEMYKSYLVGEE----------LWVLM 481
Query: 183 EFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTP 242
EF +GG L V R + + + A+A+LH ++HRD+K D+IL+T
Sbjct: 482 EFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGR-- 539
Query: 243 ILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEV-WEGHYTAK 301
+K++DFG CA Q +K+V K S G+ ++MAPEV Y +
Sbjct: 540 -VKLSDFGF---CA----------QISKDVPKRK----SLVGTPYWMAPEVISRSLYATE 581
Query: 302 ADIFALGIIIWAMI--ERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQ 359
DI++LGI++ M+ E F DS V + L ++P +L
Sbjct: 582 VDIWSLGIMVIEMVDGEPPYFSDSP----------------VQAMKRLRDSPPPKL---- 621
Query: 360 KRRTSMSEGIKQLLKDMLAANPQDRPDAFEL 390
K +S ++ L+ ML +PQ+R A EL
Sbjct: 622 KNSHKVSPVLRDFLERMLVRDPQERATAQEL 652
>gi|191252780 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 81.6 bits (200), Expect = 1e-15
Identities = 102/391 (26%), Positives = 158/391 (40%), Gaps = 92/391 (23%)
Query: 13 QSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAP----------GEAFLARRRPEGGG 62
Q P R + PR ++ + DP A+ E F A R
Sbjct: 341 QLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQ 400
Query: 63 GSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLK 122
G R +IG GS G+V A SG +VAVK + L+
Sbjct: 401 GDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVK-------------------MMDLR 441
Query: 123 RRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVM 182
++ + + F E V+ R+ H N + + ++ L GE LW +M
Sbjct: 442 KQQRRELLFNEVVIMRD-----YQHFN-----VVEMYKSYLVGEE----------LWVLM 481
Query: 183 EFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTP 242
EF +GG L V R + + + A+A+LH ++HRD+K D+IL+T
Sbjct: 482 EFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGR-- 539
Query: 243 ILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEV-WEGHYTAK 301
+K++DFG CA Q +K+V K S G+ ++MAPEV Y +
Sbjct: 540 -VKLSDFGF---CA----------QISKDVPKRK----SLVGTPYWMAPEVISRSLYATE 581
Query: 302 ADIFALGIIIWAMI--ERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQ 359
DI++LGI++ M+ E F DS V + L ++P +L
Sbjct: 582 VDIWSLGIMVIEMVDGEPPYFSDSP----------------VQAMKRLRDSPPPKL---- 621
Query: 360 KRRTSMSEGIKQLLKDMLAANPQDRPDAFEL 390
K +S ++ L+ ML +PQ+R A EL
Sbjct: 622 KNSHKVSPVLRDFLERMLVRDPQERATAQEL 652
>gi|9910476 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 81.6 bits (200), Expect = 1e-15
Identities = 102/391 (26%), Positives = 158/391 (40%), Gaps = 92/391 (23%)
Query: 13 QSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAP----------GEAFLARRRPEGGG 62
Q P R + PR ++ + DP A+ E F A R
Sbjct: 341 QLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQ 400
Query: 63 GSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLK 122
G R +IG GS G+V A SG +VAVK + L+
Sbjct: 401 GDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVK-------------------MMDLR 441
Query: 123 RRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVM 182
++ + + F E V+ R+ H N + + ++ L GE LW +M
Sbjct: 442 KQQRRELLFNEVVIMRD-----YQHFN-----VVEMYKSYLVGEE----------LWVLM 481
Query: 183 EFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTP 242
EF +GG L V R + + + A+A+LH ++HRD+K D+IL+T
Sbjct: 482 EFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGR-- 539
Query: 243 ILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEV-WEGHYTAK 301
+K++DFG CA Q +K+V K S G+ ++MAPEV Y +
Sbjct: 540 -VKLSDFGF---CA----------QISKDVPKRK----SLVGTPYWMAPEVISRSLYATE 581
Query: 302 ADIFALGIIIWAMI--ERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQ 359
DI++LGI++ M+ E F DS V + L ++P +L
Sbjct: 582 VDIWSLGIMVIEMVDGEPPYFSDSP----------------VQAMKRLRDSPPPKL---- 621
Query: 360 KRRTSMSEGIKQLLKDMLAANPQDRPDAFEL 390
K +S ++ L+ ML +PQ+R A EL
Sbjct: 622 KNSHKVSPVLRDFLERMLVRDPQERATAQEL 652
>gi|217330559 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 80.9 bits (198), Expect = 2e-15
Identities = 64/222 (28%), Positives = 104/222 (46%), Gaps = 44/222 (19%)
Query: 173 EEPCYLWFVMEFCEGGDLNQYVLSRRP-DPATNKSFMLQLTSAIAFLHKNHIVHRDLKPD 231
E P ++ VME+C GGDL Y+ ++ T + F+ Q+ +A+ LH I+HRDLKP
Sbjct: 76 ELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQ 135
Query: 232 NILIT--ERSGTPI----LKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGS 285
NIL++ R + + +K+ADFG ++ + ++ CGS
Sbjct: 136 NILLSYANRRKSSVSGIRIKIADFGFARYLH------------------SNMMAATLCGS 177
Query: 286 DFYMAPEV-WEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVG 344
YMAPEV HY AKAD++++G +I+ + + + ++L Y K
Sbjct: 178 PMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEK--------- 228
Query: 345 EALLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPD 386
N + IP++ S + LL +L N +DR D
Sbjct: 229 -----NRSLMPSIPRE----TSPYLANLLLGLLQRNQKDRMD 261
>gi|217330557 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 80.9 bits (198), Expect = 2e-15
Identities = 64/222 (28%), Positives = 104/222 (46%), Gaps = 44/222 (19%)
Query: 173 EEPCYLWFVMEFCEGGDLNQYVLSRRP-DPATNKSFMLQLTSAIAFLHKNHIVHRDLKPD 231
E P ++ VME+C GGDL Y+ ++ T + F+ Q+ +A+ LH I+HRDLKP
Sbjct: 76 ELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQ 135
Query: 232 NILIT--ERSGTPI----LKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGS 285
NIL++ R + + +K+ADFG ++ + ++ CGS
Sbjct: 136 NILLSYANRRKSSVSGIRIKIADFGFARYLH------------------SNMMAATLCGS 177
Query: 286 DFYMAPEV-WEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVG 344
YMAPEV HY AKAD++++G +I+ + + + ++L Y K
Sbjct: 178 PMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEK--------- 228
Query: 345 EALLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPD 386
N + IP++ S + LL +L N +DR D
Sbjct: 229 -----NRSLMPSIPRE----TSPYLANLLLGLLQRNQKDRMD 261
>gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 80.9 bits (198), Expect = 2e-15
Identities = 84/323 (26%), Positives = 127/323 (39%), Gaps = 77/323 (23%)
Query: 12 TQSPERKRRSPVPRAPSTKL-RPAAAARAMDPVAAEAPG----------------EAFLA 54
++ P R R +P P P A A P A PG E F A
Sbjct: 247 SRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRA 306
Query: 55 RRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAE 114
+ G R +IG GS G+V A SG VAVKK+
Sbjct: 307 ALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM-------------- 352
Query: 115 FWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEE 174
L+++ + + F E V+ R+ H N + + + L G+
Sbjct: 353 -----DLRKQQRRELLFNEVVIMRD-----YQHEN-----VVEMYNSYLVGDE------- 390
Query: 175 PCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNIL 234
LW VMEF EGG L V R + + L + A++ LH ++HRD+K D+IL
Sbjct: 391 ---LWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSIL 447
Query: 235 ITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPE-V 293
+T +K++DFG + PR K S G+ ++MAPE +
Sbjct: 448 LTHDGR---VKLSDFGFCAQVSKEVPRRK-----------------SLVGTPYWMAPELI 487
Query: 294 WEGHYTAKADIFALGIIIWAMIE 316
Y + DI++LGI++ M++
Sbjct: 488 SRLPYGPEVDIWSLGIMVIEMVD 510
>gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 80.9 bits (198), Expect = 2e-15
Identities = 84/323 (26%), Positives = 127/323 (39%), Gaps = 77/323 (23%)
Query: 12 TQSPERKRRSPVPRAPSTKL-RPAAAARAMDPVAAEAPG----------------EAFLA 54
++ P R R +P P P A A P A PG E F A
Sbjct: 94 SRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRA 153
Query: 55 RRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAE 114
+ G R +IG GS G+V A SG VAVKK+
Sbjct: 154 ALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM-------------- 199
Query: 115 FWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEE 174
L+++ + + F E V+ R+ H N + + + L G+
Sbjct: 200 -----DLRKQQRRELLFNEVVIMRD-----YQHEN-----VVEMYNSYLVGDE------- 237
Query: 175 PCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNIL 234
LW VMEF EGG L V R + + L + A++ LH ++HRD+K D+IL
Sbjct: 238 ---LWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSIL 294
Query: 235 ITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPE-V 293
+T +K++DFG + PR K S G+ ++MAPE +
Sbjct: 295 LTHDGR---VKLSDFGFCAQVSKEVPRRK-----------------SLVGTPYWMAPELI 334
Query: 294 WEGHYTAKADIFALGIIIWAMIE 316
Y + DI++LGI++ M++
Sbjct: 335 SRLPYGPEVDIWSLGIMVIEMVD 357
>gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 80.9 bits (198), Expect = 2e-15
Identities = 84/323 (26%), Positives = 127/323 (39%), Gaps = 77/323 (23%)
Query: 12 TQSPERKRRSPVPRAPSTKL-RPAAAARAMDPVAAEAPG----------------EAFLA 54
++ P R R +P P P A A P A PG E F A
Sbjct: 94 SRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRA 153
Query: 55 RRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAE 114
+ G R +IG GS G+V A SG VAVKK+
Sbjct: 154 ALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM-------------- 199
Query: 115 FWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEE 174
L+++ + + F E V+ R+ H N + + + L G+
Sbjct: 200 -----DLRKQQRRELLFNEVVIMRD-----YQHEN-----VVEMYNSYLVGDE------- 237
Query: 175 PCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNIL 234
LW VMEF EGG L V R + + L + A++ LH ++HRD+K D+IL
Sbjct: 238 ---LWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSIL 294
Query: 235 ITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPE-V 293
+T +K++DFG + PR K S G+ ++MAPE +
Sbjct: 295 LTHDGR---VKLSDFGFCAQVSKEVPRRK-----------------SLVGTPYWMAPELI 334
Query: 294 WEGHYTAKADIFALGIIIWAMIE 316
Y + DI++LGI++ M++
Sbjct: 335 SRLPYGPEVDIWSLGIMVIEMVD 357
>gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 80.9 bits (198), Expect = 2e-15
Identities = 84/323 (26%), Positives = 127/323 (39%), Gaps = 77/323 (23%)
Query: 12 TQSPERKRRSPVPRAPSTKL-RPAAAARAMDPVAAEAPG----------------EAFLA 54
++ P R R +P P P A A P A PG E F A
Sbjct: 247 SRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRA 306
Query: 55 RRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAE 114
+ G R +IG GS G+V A SG VAVKK+
Sbjct: 307 ALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM-------------- 352
Query: 115 FWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEE 174
L+++ + + F E V+ R+ H N + + + L G+
Sbjct: 353 -----DLRKQQRRELLFNEVVIMRD-----YQHEN-----VVEMYNSYLVGDE------- 390
Query: 175 PCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNIL 234
LW VMEF EGG L V R + + L + A++ LH ++HRD+K D+IL
Sbjct: 391 ---LWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSIL 447
Query: 235 ITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPE-V 293
+T +K++DFG + PR K S G+ ++MAPE +
Sbjct: 448 LTHDGR---VKLSDFGFCAQVSKEVPRRK-----------------SLVGTPYWMAPELI 487
Query: 294 WEGHYTAKADIFALGIIIWAMIE 316
Y + DI++LGI++ M++
Sbjct: 488 SRLPYGPEVDIWSLGIMVIEMVD 510
>gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 80.9 bits (198), Expect = 2e-15
Identities = 84/323 (26%), Positives = 127/323 (39%), Gaps = 77/323 (23%)
Query: 12 TQSPERKRRSPVPRAPSTKL-RPAAAARAMDPVAAEAPG----------------EAFLA 54
++ P R R +P P P A A P A PG E F A
Sbjct: 247 SRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRA 306
Query: 55 RRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAE 114
+ G R +IG GS G+V A SG VAVKK+
Sbjct: 307 ALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM-------------- 352
Query: 115 FWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEE 174
L+++ + + F E V+ R+ H N + + + L G+
Sbjct: 353 -----DLRKQQRRELLFNEVVIMRD-----YQHEN-----VVEMYNSYLVGDE------- 390
Query: 175 PCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNIL 234
LW VMEF EGG L V R + + L + A++ LH ++HRD+K D+IL
Sbjct: 391 ---LWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSIL 447
Query: 235 ITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPE-V 293
+T +K++DFG + PR K S G+ ++MAPE +
Sbjct: 448 LTHDGR---VKLSDFGFCAQVSKEVPRRK-----------------SLVGTPYWMAPELI 487
Query: 294 WEGHYTAKADIFALGIIIWAMIE 316
Y + DI++LGI++ M++
Sbjct: 488 SRLPYGPEVDIWSLGIMVIEMVD 510
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 80.5 bits (197), Expect = 2e-15
Identities = 61/214 (28%), Positives = 99/214 (46%), Gaps = 38/214 (17%)
Query: 173 EEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFML-QLTSAIAFLHKNHIVHRDLKPD 231
E P +L+ ME GG+L ++ R + S ++ Q+ A+++LH IVHRDLKP+
Sbjct: 98 ESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPE 157
Query: 232 NILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAP 291
N+L + V+DFGLSK+ AG L +ACG+ Y+AP
Sbjct: 158 NLLYATPFEDSKIMVSDFGLSKIQAG-------------------NMLGTACGTPGYVAP 198
Query: 292 EVWEGHYTAKA-DIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLEN 350
E+ E KA D++ALG+I + ++ E+ EL ++ E ++
Sbjct: 199 ELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYE--------FDS 250
Query: 351 PKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDR 384
P + +SE K ++ +L +PQ R
Sbjct: 251 PFWD---------DISESAKDFIRHLLERDPQKR 275
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 80.5 bits (197), Expect = 2e-15
Identities = 61/214 (28%), Positives = 99/214 (46%), Gaps = 38/214 (17%)
Query: 173 EEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFML-QLTSAIAFLHKNHIVHRDLKPD 231
E P +L+ ME GG+L ++ R + S ++ Q+ A+++LH IVHRDLKP+
Sbjct: 164 ESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPE 223
Query: 232 NILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAP 291
N+L + V+DFGLSK+ AG L +ACG+ Y+AP
Sbjct: 224 NLLYATPFEDSKIMVSDFGLSKIQAG-------------------NMLGTACGTPGYVAP 264
Query: 292 EVWEGHYTAKA-DIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLEN 350
E+ E KA D++ALG+I + ++ E+ EL ++ E ++
Sbjct: 265 ELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYE--------FDS 316
Query: 351 PKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDR 384
P + +SE K ++ +L +PQ R
Sbjct: 317 PFWD---------DISESAKDFIRHLLERDPQKR 341
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 80.1 bits (196), Expect = 3e-15
Identities = 60/200 (30%), Positives = 93/200 (46%), Gaps = 19/200 (9%)
Query: 149 NKSSQLYLRLVETSLKGERILGYAEEPC------------YLWFVMEFCEGGDLNQYVLS 196
NK + + ++ + IL +AE P +L VME+ EGGD + +
Sbjct: 413 NKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKN 472
Query: 197 RRPDPATN-KSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVC 255
P P + + + A+ +LH IVHRDLKPDN+L+T +K+ DFGLSKV
Sbjct: 473 MGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGH---IKLTDFGLSKV- 528
Query: 256 AGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEV-WEGHYTAKADIFALGIIIWAM 314
GL + + + ++ CG+ Y+APEV Y D +A+GII++
Sbjct: 529 -GLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEF 587
Query: 315 IERITFIDSETKKELLGTYI 334
+ +T +EL G I
Sbjct: 588 LVGCVPFFGDTPEELFGQVI 607
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 79.3 bits (194), Expect = 6e-15
Identities = 71/262 (27%), Positives = 118/262 (45%), Gaps = 65/262 (24%)
Query: 60 GGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALT 119
G G Y L +GRG + VV A +G +VAVK I D + LA +
Sbjct: 7 GYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVI--DKTKLDTLATGHLFQEV 64
Query: 120 SLKR--RHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCY 177
+ +H N+V+ E +++T K
Sbjct: 65 RCMKLVQHPNIVRLYE------------------------VIDTQTK------------- 87
Query: 178 LWFVMEFCEGGDLNQYVLSRRP--DPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILI 235
L+ ++E +GGD+ Y++ + K + Q+ AI++ HK H+VHRDLKP+N++
Sbjct: 88 LYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVF 147
Query: 236 TERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWE 295
E+ G ++K+ DFG S + + G + L+++CGS Y APE+
Sbjct: 148 FEKQG--LVKLTDFGFSN-------KFQPGKK-----------LTTSCGSLAYSAPEILL 187
Query: 296 G-HYTAKA-DIFALGIIIWAMI 315
G Y A A DI++LG+I++ ++
Sbjct: 188 GDEYDAPAVDIWSLGVILFMLV 209
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 79.3 bits (194), Expect = 6e-15
Identities = 71/262 (27%), Positives = 118/262 (45%), Gaps = 65/262 (24%)
Query: 60 GGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALT 119
G G Y L +GRG + VV A +G +VAVK I D + LA +
Sbjct: 7 GYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVI--DKTKLDTLATGHLFQEV 64
Query: 120 SLKR--RHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCY 177
+ +H N+V+ E +++T K
Sbjct: 65 RCMKLVQHPNIVRLYE------------------------VIDTQTK------------- 87
Query: 178 LWFVMEFCEGGDLNQYVLSRRP--DPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILI 235
L+ ++E +GGD+ Y++ + K + Q+ AI++ HK H+VHRDLKP+N++
Sbjct: 88 LYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVF 147
Query: 236 TERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWE 295
E+ G ++K+ DFG S + + G + L+++CGS Y APE+
Sbjct: 148 FEKQG--LVKLTDFGFSN-------KFQPGKK-----------LTTSCGSLAYSAPEILL 187
Query: 296 G-HYTAKA-DIFALGIIIWAMI 315
G Y A A DI++LG+I++ ++
Sbjct: 188 GDEYDAPAVDIWSLGVILFMLV 209
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 79.3 bits (194), Expect = 6e-15
Identities = 60/214 (28%), Positives = 98/214 (45%), Gaps = 25/214 (11%)
Query: 149 NKSSQLYLRLVETSLKGERILGYAEEPC------------YLWFVMEFCEGGDLNQYVLS 196
NK + + ++ IL +AE P +L VME+ EGGD + +
Sbjct: 399 NKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKN 458
Query: 197 RRPDPATN-KSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGLSKVC 255
P P + + + A+ +LH IVHRDLKPDN+LIT +K+ DFGLSK+
Sbjct: 459 MGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGH---IKLTDFGLSKI- 514
Query: 256 AGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEV-WEGHYTAKADIFALGIIIWAM 314
GL + + + ++ CG+ Y+APEV + Y D +A+G++++
Sbjct: 515 -GLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEF 573
Query: 315 IERITFIDSETKKELLGTYIK------QGTEIVP 342
+ +T +EL G + +G E +P
Sbjct: 574 LVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALP 607
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,695,338
Number of Sequences: 37866
Number of extensions: 735135
Number of successful extensions: 5133
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 583
Number of HSP's successfully gapped in prelim test: 284
Number of HSP's that attempted gapping in prelim test: 3171
Number of HSP's gapped (non-prelim): 1401
length of query: 401
length of database: 18,247,518
effective HSP length: 104
effective length of query: 297
effective length of database: 14,309,454
effective search space: 4249907838
effective search space used: 4249907838
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.